                         SEQUENCE LISTING

<110>  INSERM
       Universit d'Aix-Marseille
       CNRS
       Institut Paoli-Calmettes
 
<120>  ANTIBODIES HAVING SPECIFICITY FOR NECTIN-4 AND USES THEREOF

<130>  BCT200291QT

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Leu Ser Leu Gly Ala Glu Met Trp Gly Pro Glu Ala Trp Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Leu Ala Ser Phe Thr Gly Arg Cys Pro Ala Gly 
            20                  25                  30          


Glu Leu Glu Thr Ser Asp Val Val Thr Val Val Leu Gly Gln Asp Ala 
        35                  40                  45              


Lys Leu Pro Cys Phe Tyr Arg Gly Asp Ser Gly Glu Gln Val Gly Gln 
    50                  55                  60                  


Val Ala Trp Ala Arg Val Asp Ala Gly Glu Gly Ala Gln Glu Leu Ala 
65                  70                  75                  80  


Leu Leu His Ser Lys Tyr Gly Leu His Val Ser Pro Ala Tyr Glu Gly 
                85                  90                  95      


Arg Val Glu Gln Pro Pro Pro Pro Arg Asn Pro Leu Asp Gly Ser Val 
            100                 105                 110         


Leu Leu Arg Asn Ala Val Gln Ala Asp Glu Gly Glu Tyr Glu Cys Arg 
        115                 120                 125             


Val Ser Thr Phe Pro Ala Gly Ser Phe Gln Ala Arg Leu Arg Leu Arg 
    130                 135                 140                 


Val Leu Val Pro Pro Leu Pro Ser Leu Asn Pro Gly Pro Ala Leu Glu 
145                 150                 155                 160 


Glu Gly Gln Gly Leu Thr Leu Ala Ala Ser Cys Thr Ala Glu Gly Ser 
                165                 170                 175     


Pro Ala Pro Ser Val Thr Trp Asp Thr Glu Val Lys Gly Thr Thr Ser 
            180                 185                 190         


Ser Arg Ser Phe Lys His Ser Arg Ser Ala Ala Val Thr Ser Glu Phe 
        195                 200                 205             


His Leu Val Pro Ser Arg Ser Met Asn Gly Gln Pro Leu Thr Cys Val 
    210                 215                 220                 


Val Ser His Pro Gly Leu Leu Gln Asp Gln Arg Ile Thr His Ile Leu 
225                 230                 235                 240 


His Val Ser Phe Leu Ala Glu Ala Ser Val Arg Gly Leu Glu Asp Gln 
                245                 250                 255     


Asn Leu Trp His Ile Gly Arg Glu Gly Ala Met Leu Lys Cys Leu Ser 
            260                 265                 270         


Glu Gly Gln Pro Pro Pro Ser Tyr Asn Trp Thr Arg Leu Asp Gly Pro 
        275                 280                 285             


Leu Pro Ser Gly Val Arg Val Asp Gly Asp Thr Leu Gly Phe Pro Pro 
    290                 295                 300                 


Leu Thr Thr Glu His Ser Gly Ile Tyr Val Cys His Val Ser Asn Glu 
305                 310                 315                 320 


Phe Ser Ser Arg Asp Ser Gln Val Thr Val Asp Val Leu Asp Pro Gln 
                325                 330                 335     


Glu Asp Ser Gly Lys Gln Val Asp Leu Val Ser Ala Ser Val Val Val 
            340                 345                 350         


Val Gly Val Ile Ala Ala Leu Leu Phe Cys Leu Leu Val Val Val Val 
        355                 360                 365             


Val Leu Met Ser Arg Tyr His Arg Arg Lys Ala Gln Gln Met Thr Gln 
    370                 375                 380                 


Lys Tyr Glu Glu Glu Leu Thr Leu Thr Arg Glu Asn Ser Ile Arg Arg 
385                 390                 395                 400 


Leu His Ser His His Thr Asp Pro Arg Ser Gln Pro Glu Glu Ser Val 
                405                 410                 415     


Gly Leu Arg Ala Glu Gly His Pro Asp Ser Leu Lys Asp Asn Ser Ser 
            420                 425                 430         


Cys Ser Val Met Ser Glu Glu Pro Glu Gly Arg Ser Tyr Ser Thr Leu 
        435                 440                 445             


Thr Thr Val Arg Glu Ile Glu Thr Gln Thr Glu Leu Leu Ser Pro Gly 
    450                 455                 460                 


Ser Gly Arg Ala Glu Glu Glu Glu Asp Gln Asp Glu Gly Ile Lys Gln 
465                 470                 475                 480 


Ala Met Asn His Phe Val Gln Glu Asn Gly Thr Leu Arg Ala Lys Pro 
                485                 490                 495     


Thr Gly Asn Gly Ile Tyr Ile Asn Gly Arg Gly His Leu Val 
            500                 505                 510 


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HCDR1 mAb 5A12.2

<400>  2

Gly Phe Thr Phe Asn Ser Met Tyr 
1               5               


<210>  3
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR2 mAb 5A12.2

<400>  3

Ile Tyr Ala Gly Thr Gly Gly Thr 
1               5               


<210>  4
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  HCDR3 mAb 5A12.2

<400>  4

Ala Ile Arg Ser Gly Phe Val Pro Met Asp Tyr Trp Gly 
1               5                   10              


<210>  5
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR1 mAb 5A12.2

<400>  5

Gln Ser Val Ser Asn Asp 
1               5       


<210>  6
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR2 mAb 5A12.2

<400>  6

Tyr Ala Ser 
1               


<210>  7
<211>  6
<212>  PRT
<213>  artificial sequence

<220>
<223>  LCDR3 mAb 5A12.2

<400>  7

Gln Gln Asp Tyr Ser Ser 
1               5       


<210>  8
<211>  118
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH mAb 5A12.2

<400>  8

Gln Ile Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Thr Ser Gly Phe Thr Phe Asn Ser Met 
            20                  25                  30          


Tyr Ile Ser Trp Leu Lys Gln Lys Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Ala Trp Ile Tyr Ala Gly Thr Gly Gly Thr Arg Phe Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Lys Val Gln Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Thr Asp Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ile Arg Ser Gly Phe Val Pro Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  9
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL mAb 5A12.2

<400>  9

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Ser Asn Asp 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser Thr Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  354
<212>  DNA
<213>  artificial sequence

<220>
<223>  VH mAb 5A12.2

<400>  10
cagatccagc tgcagcagtc tggagctgag ctggtgaagc ctggggcttc agtgacgctg       60

tcctgcaaga cttctggctt caccttcaac agtatgtata taagttggtt gaagcaaaag      120

cctggacaga gtcttgagtg gattgcatgg atttatgctg gaactggtgg tactaggttt      180

aatcagaagt tcacaggcaa ggtccaactg actgtagaca catcctccag cacagcctac      240

atgcaattca gcagcctgac aactgacgac tctgccatct attactgtgc catcaggtcg      300

ggcttcgtcc ctatggacta ctggggtcaa gggacctcag tcaccgtctc ctca            354


<210>  11
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  VL mAb 5A12.2

<400>  11
agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc       60

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca      120

ggacagtctc ctaaactcct gatatactat gcatccaatc gctacactgg agtccctgat      180

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      240

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa a                                                321


