                         б

<110>  д(TANAKAJUNMI)
<120>  һѪܰ͹ؼĶļ;

<130>  F20W7830

<160>  4
<170>  PatentIn version 3.1

<210>  1
<211>  5672
<212>  DNA
<213>  

<220>
<221>  CDS
<222>  (316)..(2631)
<223>  

<400>  1
aagcaccact gcagcagacc ttgttaattt tttttttttt tctttccaca caacagttgt     60

gcctcattat ccggtgcctg gctcggaatt tttttttttt tttttctttt tggagggttt    120

gaagtttctg tgcttcagtg actgttacag aagaagaggt gttagtgttg ccatgaggtc    180

ttgattgtct gcatttatga atgaaactga cctaaatcac ctgttacctc cagtttccag    240

attgtttgaa cttctctggc cgcacaatac aggaaggaag actaaagcag caaagggacc    300

tacagcgtct gcagc atg ggc tgg tta act agg att gtc tgt ctt ttc tgg     351
                 Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp        
                 1               5                   10                 

gga gta tta ctt aca gca aga gca aac tat cag aat ggg aag aac aat      399
Gly Val Leu Leu Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn         
        15                  20                  25                      

gtg cca agg ctg aaa tta tcc tac aaa gaa atg ttg gaa tcc aac aat      447
Val Pro Arg Leu Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn         
    30                  35                  40                          

gtg atc act ttc aat ggc ttg gcc aac agc tcc agt tat cat acc ttc      495
Val Ile Thr Phe Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe         
45                  50                  55                  60          

ctt ttg gat gag gaa cgg agt agg ctg tat gtt gga gca aag gat cac      543
Leu Leu Asp Glu Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His         
                65                  70                  75              

ata ttt tca ttc gac ctg gtt aat atc aag gat ttt caa aag att gtg      591
Ile Phe Ser Phe Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val         
            80                  85                  90                  

tgg cca gta tct tac acc aga aga gat gaa tgc aag tgg gct gga aaa      639
Trp Pro Val Ser Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys         
        95                  100                 105                     

gac atc ctg aaa gaa tgt gct aat ttc atc aag gta ctt aag gca tat      687
Asp Ile Leu Lys Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr         
    110                 115                 120                         

aat cag act cac ttg tac gcc tgt gga acg ggg gct ttt cat cca att      735
Asn Gln Thr His Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile         
125                 130                 135                 140         

tgc acc tac att gaa att gga cat cat cct gag gac aat att ttt aag      783
Cys Thr Tyr Ile Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys         
                145                 150                 155             

ctg gag aac tca cat ttt gaa aac ggc cgt ggg aag agt cca tat gac      831
Leu Glu Asn Ser His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp         
            160                 165                 170                 

cct aag ctg ctg aca gca tcc ctt tta ata gat gga gaa tta tac tct      879
Pro Lys Leu Leu Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser         
        175                 180                 185                     

gga act gca gct gat ttt atg ggg cga gac ttt gct atc ttc cga act      927
Gly Thr Ala Ala Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr         
    190                 195                 200                         

ctt ggg cac cac cac cca atc agg aca gag cag cat gat tcc agg tgg      975
Leu Gly His His His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp         
205                 210                 215                 220         

ctc aat gat cca aag ttc att agt gcc cac ctc atc tca gag agt gac     1023
Leu Asn Asp Pro Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp         
                225                 230                 235             

aat cct gaa gat gac aaa gta tac ttt ttc ttc cgt gaa aat gca ata     1071
Asn Pro Glu Asp Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile         
            240                 245                 250                 

gat gga gaa cac tct gga aaa gct act cac gct aga ata ggt cag ata     1119
Asp Gly Glu His Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile         
        255                 260                 265                     

tgc aag aat gac ttt gga ggg cac aga agt ctg gtg aat aaa tgg aca     1167
Cys Lys Asn Asp Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr         
    270                 275                 280                         

aca ttc ctc aaa gct cgt ctg att tgc tca gtg cca ggt cca aat ggc     1215
Thr Phe Leu Lys Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly         
285                 290                 295                 300         

att gac act cat ttt gat gaa ctg cag gat gta ttc cta atg aac ttt     1263
Ile Asp Thr His Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe         
                305                 310                 315             

aaa gat cct aaa aat cca gtt gta tat gga gtg ttt acg act tcc agt     1311
Lys Asp Pro Lys Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser         
            320                 325                 330                 

aac att ttc aag gga tca gcc gtg tgt atg tat agc atg agt gat gtg     1359
Asn Ile Phe Lys Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val         
        335                 340                 345                     

aga agg gtg ttc ctt ggt cca tat gcc cac agg gat gga ccc aac tat     1407
Arg Arg Val Phe Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr         
    350                 355                 360                         

caa tgg gtg cct tat caa gga aga gtc ccc tat cca cgg cca gga act     1455
Gln Trp Val Pro Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr         
365                 370                 375                 380         

tgt ccc agc aaa aca ttt ggt ggt ttt gac tct aca aag gac ctt cct     1503
Cys Pro Ser Lys Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro         
                385                 390                 395             

gat gat gtt ata acc ttt gca aga agt cat cca gcc atg tac aat cca     1551
Asp Asp Val Ile Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro         
            400                 405                 410                 

gtg ttt cct atg aac aat cgc cca ata gtg atc aaa acg gat gta aat     1599
Val Phe Pro Met Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn         
        415                 420                 425                     

tat caa ttt aca caa att gtc gta gac cga gtg gat gca gaa gat gga     1647
Tyr Gln Phe Thr Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly         
    430                 435                 440                         

cag tat gat gtt atg ttt atc gga aca gat gtt ggg acc gtt ctt aaa     1695
Gln Tyr Asp Val Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys         
445                 450                 455                 460         

gta gtt tca att cct aag gag act tgg tat gat tta gaa gag gtt ctg     1743
Val Val Ser Ile Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu         
                465                 470                 475             

ctg gaa gaa atg aca gtt ttt cgg gaa ccg act gct att tca gca atg     1791
Leu Glu Glu Met Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met         
            480                 485                 490                 

gag ctt tcc act aag cag caa caa cta tat att ggt tca acg gct ggg     1839
Glu Leu Ser Thr Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly         
        495                 500                 505                     

gtt gcc cag ctc cct tta cac cgg tgt gat att tac ggg aaa gcg tgt     1887
Val Ala Gln Leu Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys         
    510                 515                 520                         

gct gag tgt tgc ctc gcc cga gac cct tac tgt gct tgg gat ggt tct     1935
Ala Glu Cys Cys Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser         
525                 530                 535                 540         

gca tgt tct cgc tat ttt ccc act gca aag aga cgc aca aga cga caa     1983
Ala Cys Ser Arg Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln         
                545                 550                 555             

gat ata aga aat gga gac cca ctg act cac tgt tca gac tta cac cat     2031
Asp Ile Arg Asn Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His         
            560                 565                 570                 

gat aat cac cat ggc cac agc cct gaa gag aga atc atc tat ggt gta     2079
Asp Asn His His Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val         
        575                 580                 585                     

gag aat agt agc aca ttt ttg gaa tgc agt ccg aag tcg cag aga gcg     2127
Glu Asn Ser Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala         
    590                 595                 600                         

ctg gtc tat tgg caa ttc cag agg cga aat gaa gag cga aaa gaa gag     2175
Leu Val Tyr Trp Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu         
605                 610                 615                 620         

atc aga gtg gat gat cat atc atc agg aca gat caa ggc ctt ctg cta     2223
Ile Arg Val Asp Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu         
                625                 630                 635             

cgt agt cta caa cag aag gat tca ggc aat tac ctc tgc cat gcg gtg     2271
Arg Ser Leu Gln Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val         
            640                 645                 650                 

gaa cat ggg ttc ata caa act ctt ctt aag gta acc ctg gaa gtc att     2319
Glu His Gly Phe Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile         
        655                 660                 665                     

gac aca gag cat ttg gaa gaa ctt ctt cat aaa gat gat gat gga gat     2367
Asp Thr Glu His Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp         
    670                 675                 680                         

ggc tct aag acc aaa gaa atg tcc aat agc atg aca cct agc cag aag     2415
Gly Ser Lys Thr Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys         
685                 690                 695                 700         

gtc tgg tac aga gac ttc atg cag ctc atc aac cac ccc aat ctc aac     2463
Val Trp Tyr Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn         
                705                 710                 715             

aca atg gat gag ttc tgt gaa caa gtt tgg aaa agg gac cga aaa caa     2511
Thr Met Asp Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln         
            720                 725                 730                 

cgt cgg caa agg cca gga cat acc cca ggg aac agt aac aaa tgg aag     2559
Arg Arg Gln Arg Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys         
        735                 740                 745                     

cac tta caa gaa aat aag aaa ggt aga aac agg agg acc cac gaa ttt     2607
His Leu Gln Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe         
    750                 755                 760                         

gag agg gca ccc agg agt gtc tga gctgcattac ctctagaaac ctcaaacaag    2661
Glu Arg Ala Pro Arg Ser Val                                             
765                 770                                                 

tagaaacttg cctagacaat aactggaaaa acaaatgcaa tatacatgaa cttttttcat   2721

ggcattatgt ggatgtttac aatggtggga aattcagctg agttccacca attataaatt   2781

aaatccatga gtaactttcc taataggctt tttttcctaa taccaccacc taacagagaa   2841

cacaggtgaa tgcagatgtt cactttagca gacttaatgt ttcctatgag atttcactgt   2901

acaggtttgt ctttcttctt tgcctgagaa ataaaaatgt catttgccat attgccatct   2961

aaaggagaaa aactgcatca gcaaagccat tgtattgaac taaaagttta aaatgaactg   3021

catggattta ctaagctgat gaatattcca aaacgtggtt ggattcaagg atatattttg   3081

tctaccggcc ctcatgtttg tatgtacttg aggagtaaaa tgagtaaaat gatactgaat   3141

gaaatgttct gtggaaatat taaaaaaaaa aaaaaacata agccatccat catccagaag   3201

aaaaatggaa tacactgatc tactactgat gtcttctttc agctttgatc taaagatgta   3261

ttttattaaa actataattt aaatgtacca tgaaaaatat gcagtaaaaa ttagttgttt   3321

tctaagctag agtaggattt gtcttacaat tattgtgcta tgtagttttt gttttaaaaa   3381

ttccaatggt gtgctgcttt ctttggacat tttattttca attctataag agggatagat   3441

gacattgttc tagaaacaca tatacatcat taagagtgaa tctctaaaac caggatataa   3501

attatgcttt atttctctga gaaaatcaaa caaatggaag ctgttcacac ctccccttct   3561

ttaagcatta tctaaattaa tttttacttg cataatgttc ttagaaaaaa aaacagaaca   3621

tttaagcagg aaaaaaggaa gaaacaagtt gatttttaag tgcattttac tataatgaat   3681

caatgaaggg aaaaggaact gcatatttca tgaaaataat aagcattgtc ttaatatact   3741

gttaatagaa aatgtgtctt aattccgtgc ttgaatccct gcatgatatt tgagactaag   3801

atctctctta tgattctacc aagaattata tctgtgtcac ttaatttttt taaaagagag   3861

agatcaataa ctattcagag caacatgtta aaggcaaagt ttccaatcat ttacatctgt   3921

atcaggtgcc tcttaccttt ccttatttaa gacaattatt tgtacaagaa acacatgact   3981

cttttcatat caatgggagg gacttttcta caaagtattt tccaggatgc aacccacatt   4041

taaacaatgt aaaattcttt gtttcctgca acaacttaca aaataaggta aaagactaaa   4101

attcaagatt tgcttccttc attgtcctaa gacgattcgt tgagaatcac tgactttgag   4161

atatttaaaa ctttcagcat tatactgtgg tttcttttgc actgcactca cctattcagg   4221

actcctcccc caggttcctc atcatgcaca aaaatgcaaa gaaaacatct tattagtaat   4281

taatgaagca acattgaaat tctaactcta gctgtctttg gattctaatt aactcagcat   4341

caatttctca cctcagacta cagtgaattt ttatttccta tcagctgaaa tatttcacag   4401

atggaagctc atgtttcagt tttaatgact gccttgaata aacaagttgt tgccacttgt   4461

ttcaaacaaa agcctaaaaa taatctacat tcaattttag gctccattga ctaatatggt   4521

gttgcttttg gaagtactgt atatcctcac atggaagcca aattgttaaa ttatttgaag   4581

gacacaccac tgtacagaaa gtagtgtttc aaatataaat cgaagaacaa agagtgctcc   4641

aaaaaatagg tcattctttt attttcataa agtatctaaa ctgtactaac attcagtgtt   4701

gtgtttcatt ctaaatttgc agctgaaata aatttatttg cgatagcaga aatatcttat   4761

tattcatcct cagaaataaa ggatttgaag ggatagagat tatatgataa atttatagaa   4821

gactttcaga atttgaatgc attttgttta gtgttatgaa atgacaatag aaaaaagtct   4881

cgacttcaat taaaagttac acaaacaaac aaatctacag gcatgtcttt atataccatc   4941

aggtctaagt tttcaaagaa aattgtagat ataacttgca gataactcat tacagtcata   5001

atctctgccc atgtgtattg agagggggca gtttgcacga aaaagaatta ttggcccatt   5061

taataattca gctttaaata gactttgtca tatgcatgaa tcatcagaga tgaaactgtt   5121

tgagagactc atgtgacctt acgaaaatta caacagcagt cttaaagtat gaaaaagatg   5181

catcacagca gagacattat ggcccagttg atatcaaatg taaaatgtaa atgcatgtaa   5241

atgcacactt cattttatgt attatttagt aatttgcagt ggtatgtgtt taatattttt   5301

gctacctaca cattaggcaa aaaaaagatg taaataattt gggagaaaaa gaggaagaac   5361

agtgtaaaat aaaactttct ataagtactc catttcaatg tgttcaacat catcctaaaa   5421

ggcaagattt tcccacgcag gtgacaaggt ggtttatgta ctatttaagg gcggaaggtg   5481

cgtgcccgtt caataagcat gttttttgcc aggtaggaaa tatgttccat atctttactt   5541

atcattgcat ttcagatggg aactagaaaa actggagaga aaaatgtaat gaaactgctg   5601

ctgtaaatta ttccttttag catgtattca cttgctaaat acacatttct tcaaaataaa   5661

aaaaaaaaaa a                                                        5672


<210>  2
<211>  771
<212>  PRT
<213>  

<400>  2

Met Gly Trp Leu Thr Arg Ile Val Cys Leu Phe Trp Gly Val Leu Leu 
1               5                   10                  15      


Thr Ala Arg Ala Asn Tyr Gln Asn Gly Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Val Ile Thr Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asp Leu Val Asn Ile Lys Asp Phe Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


Tyr Thr Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Lys 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Ala Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Ile Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Ile Gly His His Pro Glu Asp Asn Ile Phe Lys Leu Glu Asn Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Ile Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Lys Phe Ile Ser Ala His Leu Ile Ser Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Val Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Ser Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Phe Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Val Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Ser Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Asp Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Met 
                405                 410                 415     


Asn Asn Arg Pro Ile Val Ile Lys Thr Asp Val Asn Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Val Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp Tyr Asp Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Ala Ile Ser Ala Met Glu Leu Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Thr Ala Gly Val Ala Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Ile Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ala Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu His His Asp Asn His His 
                565                 570                 575     


Gly His Ser Pro Glu Glu Arg Ile Ile Tyr Gly Val Glu Asn Ser Ser 
            580                 585                 590         


Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Leu Val Tyr Trp 
        595                 600                 605             


Gln Phe Gln Arg Arg Asn Glu Glu Arg Lys Glu Glu Ile Arg Val Asp 
    610                 615                 620                 


Asp His Ile Ile Arg Thr Asp Gln Gly Leu Leu Leu Arg Ser Leu Gln 
625                 630                 635                 640 


Gln Lys Asp Ser Gly Asn Tyr Leu Cys His Ala Val Glu His Gly Phe 
                645                 650                 655     


Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Glu His 
            660                 665                 670         


Leu Glu Glu Leu Leu His Lys Asp Asp Asp Gly Asp Gly Ser Lys Thr 
        675                 680                 685             


Lys Glu Met Ser Asn Ser Met Thr Pro Ser Gln Lys Val Trp Tyr Arg 
    690                 695                 700                 


Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu 
705                 710                 715                 720 


Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg 
                725                 730                 735     


Pro Gly His Thr Pro Gly Asn Ser Asn Lys Trp Lys His Leu Gln Glu 
            740                 745                 750         


Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro 
        755                 760                 765             


Arg Ser Val 
    770     


<210>  3
<211>  3263
<212>  DNA
<213>  ԭ

<220>
<221>  CDS
<222>  (168)..(2486)
<223>  

<400>  3
gctgatggaa gactttgtta cttgtttcta gctgggagcg acccaaagag gattatgtta     60

tgggcagaag atgttattta tgttgcctga agttccccgg cggcgcccgg caggacgggg    120

agcgccgcgg ctccggctcg cagggaccct acagtggctg ctgcagc atg ggc tgg      176
                                                    Met Gly Trp         
                                                    1                   

ctc agg ggg att gcc ttg ctt tcc ttg gga gta tta cta gca gga aga      224
Leu Arg Gly Ile Ala Leu Leu Ser Leu Gly Val Leu Leu Ala Gly Arg         
    5                   10                  15                          

gtg aac tgc cag cat gtg aag aat aac gtg cca aga ctc aaa tta tcc      272
Val Asn Cys Gln His Val Lys Asn Asn Val Pro Arg Leu Lys Leu Ser         
20                  25                  30                  35          

tat aaa gaa atg ttg gaa tcc aat aat ata gtc aat ttc aat gga cta      320
Tyr Lys Glu Met Leu Glu Ser Asn Asn Ile Val Asn Phe Asn Gly Leu         
                40                  45                  50              

gct aat agt tcc agt tac cat act ttc ctc ttg gat gaa gaa cga agt      368
Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu Glu Arg Ser         
            55                  60                  65                  

cgg ctg tat gtt gga gca aaa gac cac ata ttt tct ttc aac ctg gtt      416
Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe Asn Leu Val         
        70                  75                  80                      

aac atc aag gaa tat caa aag att gtt tgg cct gta tct cat tcc cga      464
Asn Ile Lys Glu Tyr Gln Lys Ile Val Trp Pro Val Ser His Ser Arg         
    85                  90                  95                          

agg gat gag tgt aag tgg gct gga aaa gat att ctg aga gaa tgt gct      512
Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Arg Glu Cys Ala         
100                 105                 110                 115         

aat ttc atc aag gtg ctt aag act tat aac caa aca cac ttg tac gct      560
Asn Phe Ile Lys Val Leu Lys Thr Tyr Asn Gln Thr His Leu Tyr Ala         
                120                 125                 130             

tgt gga acg ggg gct ttt cat ccc atg tgc act tat att gaa gtt gga      608
Cys Gly Thr Gly Ala Phe His Pro Met Cys Thr Tyr Ile Glu Val Gly         
            135                 140                 145                 

agc cat cct gag gac aac att ttt agg atg gaa gat tca cat ttt gaa      656
Ser His Pro Glu Asp Asn Ile Phe Arg Met Glu Asp Ser His Phe Glu         
        150                 155                 160                     

aac ggc cga ggg aaa agc cct tac gat cct aaa ttg ctg aca gct tct      704
Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu Thr Ala Ser         
    165                 170                 175                         

ctt tta gta gat gga gaa ttg tac tct ggc aca gca gca gac ttc atg      752
Leu Leu Val Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala Asp Phe Met         
180                 185                 190                 195         

ggc aga gac ttt gcc att ttc cga act ctg ggg cat cac cat cca atc      800
Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His His Pro Ile         
                200                 205                 210             

aga aca gag cag cat gac tcc cgg tgg cta aac gat ccc aga ttt att      848
Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro Arg Phe Ile         
            215                 220                 225                 

agt gct cac ctg ata cct gaa agt gat aat cca gaa gat gac aaa atc      896
Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp Asp Lys Ile         
        230                 235                 240                     

tat ttc ttc ttt cgt gaa aat gcg att gat gga gag cac act gga aaa      944
Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His Thr Gly Lys         
    245                 250                 255                         

gcc act cat gcc aga ata ggg cag atc tgt aag aat gac ttt ggt gga      992
Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp Phe Gly Gly         
260                 265                 270                 275         

cac agg agc ctt gtt aac aaa tgg aca act ttc ctc aaa gca cgt ctg     1040
His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys Ala Arg Leu         
                280                 285                 290             

att tgt tct gtg cca gga ccc aat ggt att gac aca cac ttt gat gaa     1088
Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His Phe Asp Glu         
            295                 300                 305                 

tta cag gac gtg ttc cta atg aac tct aag gac cct aaa aat cca ata     1136
Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys Asn Pro Ile         
        310                 315                 320                     

gtg tat gga gtg ttt aca act tcc agt aat atc ttc aag gga tca gca     1184
Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys Gly Ser Ala         
    325                 330                 335                         

gta tgt atg tac agc atg act gat gtg agg agg gta ttt ctt ggc ccc     1232
Val Cys Met Tyr Ser Met Thr Asp Val Arg Arg Val Phe Leu Gly Pro         
340                 345                 350                 355         

tat gcc cac cga gat ggc cca aac tac cag tgg gtt ccc tac caa ggg     1280
Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro Tyr Gln Gly         
                360                 365                 370             

cga gtt cca tat cca cgg cca gga act tgc ccc agt aaa aca ttt ggc     1328
Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys Thr Phe Gly         
            375                 380                 385                 

ggc ttt gac tcc acc aag gac ctt cct gat gaa gtt ata aca ttt gca     1376
Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Glu Val Ile Thr Phe Ala         
        390                 395                 400                     

aga agt cat cct gcc atg tat aac cca gta ttc ccc atc aac agc cgt     1424
Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile Asn Ser Arg         
    405                 410                 415                         

cca atc atg atc aaa acg gat gta gat tac cag ttc aca cag ata gta     1472
Pro Ile Met Ile Lys Thr Asp Val Asp Tyr Gln Phe Thr Gln Ile Val         
420                 425                 430                 435         

gta gat cga gta gat gca gaa gat ggt caa tac gat gtt atg ttc att     1520
Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val Met Phe Ile         
                440                 445                 450             

ggc aca gat att gga aca gtt ctt aaa gtg gtt tcc att cct aag gag     1568
Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val Ser Ile Pro Lys Glu         
            455                 460                 465                 

act tgg cat gaa tta gaa gaa gtc ttg ctg gaa gaa atg acc gtc ttt     1616
Thr Trp His Glu Leu Glu Glu Val Leu Leu Glu Glu Met Thr Val Phe         
        470                 475                 480                     

cgg gaa ccc act gtt att tca gca atg aag att tcc aca aaa cag caa     1664
Arg Glu Pro Thr Val Ile Ser Ala Met Lys Ile Ser Thr Lys Gln Gln         
    485                 490                 495                         

cag ctc tac att ggc tca gcc acc gga gtt tca cag ctt cct tta cac     1712
Gln Leu Tyr Ile Gly Ser Ala Thr Gly Val Ser Gln Leu Pro Leu His         
500                 505                 510                 515         

cgc tgt gat gtc tat gga aaa gca tgt gct gag tgt tgt ctt gca aga     1760
Arg Cys Asp Val Tyr Gly Lys Ala Cys Ala Glu Cys Cys Leu Ala Arg         
                520                 525                 530             

gac ccc tac tgc gcc tgg gat ggt tca tct tgc tca cgt tac ttt ccc     1808
Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg Tyr Phe Pro         
            535                 540                 545                 

act gct aag aga cgt act agg cga caa gac atc cga aat gga gat ccc     1856
Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn Gly Asp Pro         
        550                 555                 560                     

ctc act cac tgc tca gac ctg cag cat cat gat aac cca agt ggt cag     1904
Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn Pro Ser Gly Gln         
    565                 570                 575                         

acc ctg gag gaa aag att att tat gga gta gag aat agc agc act ttt     1952
Thr Leu Glu Glu Lys Ile Ile Tyr Gly Val Glu Asn Ser Ser Thr Phe         
580                 585                 590                 595         

ctt gag tgc agt cca aaa tct caa cgt gcc ata gtc tac tgg caa ttc     2000
Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Ile Val Tyr Trp Gln Phe         
                600                 605                 610             

cag aag caa aat gat gac cac aaa gtt gag ata aaa gtg gat gat cga     2048
Gln Lys Gln Asn Asp Asp His Lys Val Glu Ile Lys Val Asp Asp Arg         
            615                 620                 625                 

atg atc cgg aca gaa cag ggc cta ttg cta cga agt ctt caa cgg aga     2096
Met Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu Gln Arg Arg         
        630                 635                 640                     

gac tct ggt att tat ttt tgt cat gct gtg gag cat ggc ttc att caa     2144
Asp Ser Gly Ile Tyr Phe Cys His Ala Val Glu His Gly Phe Ile Gln         
    645                 650                 655                         

act ttg ctc aaa gtg aca ctg gaa gta att gat act gac cac ttg gaa     2192
Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Asp His Leu Glu         
660                 665                 670                 675         

gag ctg ctc cat aag gaa gaa gac gcc gat gcc tcc aag acc aag gat     2240
Glu Leu Leu His Lys Glu Glu Asp Ala Asp Ala Ser Lys Thr Lys Asp         
                680                 685                 690             

gct acc aat agc atg act cct agt caa aag atc tgg tat aga gac ttc     2288
Ala Thr Asn Ser Met Thr Pro Ser Gln Lys Ile Trp Tyr Arg Asp Phe         
            695                 700                 705                 

atg cag tta atc aat cac ccc aat ctc aac aca atg gat gaa ttc tgt     2336
Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp Glu Phe Cys         
        710                 715                 720                     

gag cag gtt tgg aaa aga gac cgc aag cag cgc cgg caa agg cct gcc     2384
Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln Arg Pro Ala         
    725                 730                 735                         

aat gcg cag gtg aac aca aat aag tgg aag cac cta caa gag aat aaa     2432
Asn Ala Gln Val Asn Thr Asn Lys Trp Lys His Leu Gln Glu Asn Lys         
740                 745                 750                 755         

aaa ggt agg aat agg agg acc cat gaa ttt gag agg gca cca cgg agt     2480
Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala Pro Arg Ser         
                760                 765                 770             

gtc tga gctacattac ctctagaaac ctcatctaag tagaaacttg tatagacaga      2536
Val                                                                     
                                                                        

taactggaaa aaaaatgcaa tatacatgaa ctttttcatg gcattaagtg gatgtttaca   2596

agagttgaaa gctcaaacaa tttccaccgg gtttaaatac aatatatttc taactttcct   2656

agtaagtcct tcgtctctgc tctgattcta agaccaggta gaccagagtt tcaaggatga   2716

acactcagct ggacatagct tactgctcaa aaagttctac aagagttcag caggcaggtt   2776

ttgctttctc tgttgcctga gatataaatg aaatgctgta tttcatgctg tcgtcttcaa   2836

gaaaaacaaa acccactttt catcatcagc accaccattc ctagactatg tataaaactg   2896

catgaactca ttaagctgat gaatgtctaa acacgtgatt ggacacaagg atttgttctt   2956

gttttgtcta ccagttctcc tgtttatgag tactagaaga ggaaaaacaa tgctgaatga   3016

gattgcggaa atcttaacaa cataagccat tcatcatcta gaagaacaaa aaaatgtgga   3076

gtacactggc ctactactga tgacttcttt cagctttgat ctaaagatgt attttattaa   3136

aactataatt taaatatacc atgaaaaata tgcagcaaac attagctctt ttctaaaata   3196

gattagcctc tttgtcttag aaatattgta cttcctaatt attggtttag aggggaaaaa   3256

aaaaaaa                                                             3263


<210>  4
<211>  772
<212>  PRT
<213>  ԭ

<400>  4

Met Gly Trp Leu Arg Gly Ile Ala Leu Leu Ser Leu Gly Val Leu Leu 
1               5                   10                  15      


Ala Gly Arg Val Asn Cys Gln His Val Lys Asn Asn Val Pro Arg Leu 
            20                  25                  30          


Lys Leu Ser Tyr Lys Glu Met Leu Glu Ser Asn Asn Ile Val Asn Phe 
        35                  40                  45              


Asn Gly Leu Ala Asn Ser Ser Ser Tyr His Thr Phe Leu Leu Asp Glu 
    50                  55                  60                  


Glu Arg Ser Arg Leu Tyr Val Gly Ala Lys Asp His Ile Phe Ser Phe 
65                  70                  75                  80  


Asn Leu Val Asn Ile Lys Glu Tyr Gln Lys Ile Val Trp Pro Val Ser 
                85                  90                  95      


His Ser Arg Arg Asp Glu Cys Lys Trp Ala Gly Lys Asp Ile Leu Arg 
            100                 105                 110         


Glu Cys Ala Asn Phe Ile Lys Val Leu Lys Thr Tyr Asn Gln Thr His 
        115                 120                 125             


Leu Tyr Ala Cys Gly Thr Gly Ala Phe His Pro Met Cys Thr Tyr Ile 
    130                 135                 140                 


Glu Val Gly Ser His Pro Glu Asp Asn Ile Phe Arg Met Glu Asp Ser 
145                 150                 155                 160 


His Phe Glu Asn Gly Arg Gly Lys Ser Pro Tyr Asp Pro Lys Leu Leu 
                165                 170                 175     


Thr Ala Ser Leu Leu Val Asp Gly Glu Leu Tyr Ser Gly Thr Ala Ala 
            180                 185                 190         


Asp Phe Met Gly Arg Asp Phe Ala Ile Phe Arg Thr Leu Gly His His 
        195                 200                 205             


His Pro Ile Arg Thr Glu Gln His Asp Ser Arg Trp Leu Asn Asp Pro 
    210                 215                 220                 


Arg Phe Ile Ser Ala His Leu Ile Pro Glu Ser Asp Asn Pro Glu Asp 
225                 230                 235                 240 


Asp Lys Ile Tyr Phe Phe Phe Arg Glu Asn Ala Ile Asp Gly Glu His 
                245                 250                 255     


Thr Gly Lys Ala Thr His Ala Arg Ile Gly Gln Ile Cys Lys Asn Asp 
            260                 265                 270         


Phe Gly Gly His Arg Ser Leu Val Asn Lys Trp Thr Thr Phe Leu Lys 
        275                 280                 285             


Ala Arg Leu Ile Cys Ser Val Pro Gly Pro Asn Gly Ile Asp Thr His 
    290                 295                 300                 


Phe Asp Glu Leu Gln Asp Val Phe Leu Met Asn Ser Lys Asp Pro Lys 
305                 310                 315                 320 


Asn Pro Ile Val Tyr Gly Val Phe Thr Thr Ser Ser Asn Ile Phe Lys 
                325                 330                 335     


Gly Ser Ala Val Cys Met Tyr Ser Met Thr Asp Val Arg Arg Val Phe 
            340                 345                 350         


Leu Gly Pro Tyr Ala His Arg Asp Gly Pro Asn Tyr Gln Trp Val Pro 
        355                 360                 365             


Tyr Gln Gly Arg Val Pro Tyr Pro Arg Pro Gly Thr Cys Pro Ser Lys 
    370                 375                 380                 


Thr Phe Gly Gly Phe Asp Ser Thr Lys Asp Leu Pro Asp Glu Val Ile 
385                 390                 395                 400 


Thr Phe Ala Arg Ser His Pro Ala Met Tyr Asn Pro Val Phe Pro Ile 
                405                 410                 415     


Asn Ser Arg Pro Ile Met Ile Lys Thr Asp Val Asp Tyr Gln Phe Thr 
            420                 425                 430         


Gln Ile Val Val Asp Arg Val Asp Ala Glu Asp Gly Gln Tyr Asp Val 
        435                 440                 445             


Met Phe Ile Gly Thr Asp Ile Gly Thr Val Leu Lys Val Val Ser Ile 
    450                 455                 460                 


Pro Lys Glu Thr Trp His Glu Leu Glu Glu Val Leu Leu Glu Glu Met 
465                 470                 475                 480 


Thr Val Phe Arg Glu Pro Thr Val Ile Ser Ala Met Lys Ile Ser Thr 
                485                 490                 495     


Lys Gln Gln Gln Leu Tyr Ile Gly Ser Ala Thr Gly Val Ser Gln Leu 
            500                 505                 510         


Pro Leu His Arg Cys Asp Val Tyr Gly Lys Ala Cys Ala Glu Cys Cys 
        515                 520                 525             


Leu Ala Arg Asp Pro Tyr Cys Ala Trp Asp Gly Ser Ser Cys Ser Arg 
    530                 535                 540                 


Tyr Phe Pro Thr Ala Lys Arg Arg Thr Arg Arg Gln Asp Ile Arg Asn 
545                 550                 555                 560 


Gly Asp Pro Leu Thr His Cys Ser Asp Leu Gln His His Asp Asn Pro 
                565                 570                 575     


Ser Gly Gln Thr Leu Glu Glu Lys Ile Ile Tyr Gly Val Glu Asn Ser 
            580                 585                 590         


Ser Thr Phe Leu Glu Cys Ser Pro Lys Ser Gln Arg Ala Ile Val Tyr 
        595                 600                 605             


Trp Gln Phe Gln Lys Gln Asn Asp Asp His Lys Val Glu Ile Lys Val 
    610                 615                 620                 


Asp Asp Arg Met Ile Arg Thr Glu Gln Gly Leu Leu Leu Arg Ser Leu 
625                 630                 635                 640 


Gln Arg Arg Asp Ser Gly Ile Tyr Phe Cys His Ala Val Glu His Gly 
                645                 650                 655     


Phe Ile Gln Thr Leu Leu Lys Val Thr Leu Glu Val Ile Asp Thr Asp 
            660                 665                 670         


His Leu Glu Glu Leu Leu His Lys Glu Glu Asp Ala Asp Ala Ser Lys 
        675                 680                 685             


Thr Lys Asp Ala Thr Asn Ser Met Thr Pro Ser Gln Lys Ile Trp Tyr 
    690                 695                 700                 


Arg Asp Phe Met Gln Leu Ile Asn His Pro Asn Leu Asn Thr Met Asp 
705                 710                 715                 720 


Glu Phe Cys Glu Gln Val Trp Lys Arg Asp Arg Lys Gln Arg Arg Gln 
                725                 730                 735     


Arg Pro Ala Asn Ala Gln Val Asn Thr Asn Lys Trp Lys His Leu Gln 
            740                 745                 750         


Glu Asn Lys Lys Gly Arg Asn Arg Arg Thr His Glu Phe Glu Arg Ala 
        755                 760                 765             


Pro Arg Ser Val 
    770         
