                        б

<110>  ʯҩҵ㶫޹˾Ϻʯ＼޹˾ڴʯҽҩ޹˾
 
<120>  B7-H3׿塢Ʊ;

<130>  DI19-1476-XC03

<160>  96    

<170>  PatentIn version 3.5

<210>  1
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  1

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala His Arg 
            20                  25                  30  


<210>  2
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  FR2

<400>  2

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala 
1               5                   10                  


<210>  3
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  3

Arg Phe Thr Ile Ser Gln Asp Asn Ala Asn Asp Met Val Tyr Leu Gln 
1               5                   10                  15      


Met Leu Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  4
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  FR4

<400>  4

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  5
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  5

Arg Tyr Tyr Met Ser 
1               5   


<210>  6
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  6

Ser Ile Tyr Ile Gly Ser Gly Ser Thr Asp Tyr Val Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  7
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  7

Gly Leu Tyr Gly Gly Arg Trp Asp Arg Ala Gln Tyr Lys Tyr 
1               5                   10                  


<210>  8
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  8

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Arg Ser 
            20                  25                  30  


<210>  9
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  FR2

<400>  9

Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ala Ala 
1               5                   10                  15  


<210>  10
<211>  35
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  10

Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ala Lys Asn Thr Val 
1               5                   10                  15      


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr 
            20                  25                  30          


Cys Ala Ala 
        35  


<210>  11
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  FR4

<400>  11

Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  12
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  12

Thr Ile Trp Ile Gly 
1               5   


<210>  13
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  13

Ile Tyr Ile Gly Ser Gly Ala Thr Tyr Tyr Val Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  14
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  14

Thr Gly Gly Thr Val Gly Ser Met Val Arg Phe Ser Pro Val Gly Asp 
1               5                   10                  15      


Phe Gly Tyr 
            


<210>  15
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  15

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr 
            20                  25                  30  


<210>  16
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  FR2

<400>  16

Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  17
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  17

Arg Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  18
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  FR4

<400>  18

Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  19
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  19

Asn Tyr Ala Met Ser 
1               5   


<210>  20
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  20

Gly Ile Asn Ser Asp Gly Gly Thr Tyr Tyr Ser Asn Ser Val Lys Gly 
1               5                   10                  15      


<210>  21
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  21

Gly Asn Gly Pro Ser Trp Thr Leu Gly Ser Val Asp Val Asn Ser 
1               5                   10                  15  


<210>  22
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  22

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Arg 
            20                  25                  30  


<210>  23
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  23

Arg Phe Thr Ile Ser Gln Asp Ser Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  24
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  24

Arg Asn Thr Met Gly 
1               5   


<210>  25
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  25

Ala Ile Tyr Thr Gly Gly Thr Ser Thr Ala Tyr Ala Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  26

Gly Ser Val Trp Ser Arg Tyr Thr Trp Ser Trp Pro Ser Thr Tyr Ser 
1               5                   10                  15      


Tyr 
    


<210>  27
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  27

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Ser Tyr Ser 
            20                  25                  30  


<210>  28
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  28

Arg Phe Thr Ile Ser Gln Asp Ile Ala Glu Asn Thr Val Tyr Leu Arg 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  29
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  29

Arg Lys Trp Met Gly 
1               5   


<210>  30
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  30

Ala Ile Tyr Thr Ser Gly Arg Thr Ala Val Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  31
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  31

Leu Thr Gly Ala Ser Asp Ser Pro Leu Arg Pro Ser Glu Tyr Asn Tyr 
1               5                   10                  15      


<210>  32
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  32

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  33
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  33

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr Leu Gln 
1               5                   10                  15      


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  34
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  34

Ser Tyr Asp Met Ser 
1               5   


<210>  35
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  35

Ala Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  21
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  36

Asp Pro Gly Ser Ser Leu Ala Val Gly Ala Trp Leu Lys Ala Ala Asp 
1               5                   10                  15      


Pro Phe Tyr Gly Tyr 
            20      


<210>  37
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  37

Thr Ser Gly Thr Val Gly Ser Met Val Arg Phe Ser Pro Val Gly Asp 
1               5                   10                  15      


Phe Gly Tyr 
            


<210>  38
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  38

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  39
<211>  14
<212>  PRT
<213>  ˹

<220>
<223>  FR2

<400>  39

Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val Ser 
1               5                   10                  


<210>  40
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  40

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Thr 
            20                  25                  30          


<210>  41
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  41

Gly Val Asp Met Ser 
1               5   


<210>  42
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  42

Gly Phe Gly Ser Gly Gly Glu Ser Pro Ser Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  43
<211>  6
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  43

Arg Trp Ala Glu Gly Tyr 
1               5       


<210>  44
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  44

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser 
            20                  25                  30  


<210>  45
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  45

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr Leu Gln 
1               5                   10                  15      


Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala Lys 
            20                  25                  30          


<210>  46
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  46

Arg Tyr Ser Met Ser 
1               5   


<210>  47
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  47

Gly Ile Thr Asn Gly Gly Ser Ile Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  48
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  48

Gly Ala Gly Glu Tyr Gly Pro Val Ser Asp Tyr Val Phe Ser Leu 
1               5                   10                  15  


<210>  49
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  49

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly 
            20                  25                  30  


<210>  50
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  50

Arg Phe Ala Ile Ser Glu Asp Asn Ala Lys Asn Thr Val Tyr Leu His 
1               5                   10                  15      


Met Asn Leu Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  51
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  51

Ser Asn Tyr Met Gly 
1               5   


<210>  52
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  52

Ala Ile Tyr Thr Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  53
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  53

Asp Leu Arg Leu Arg Val Ala Val Leu His Pro Tyr Gly Tyr Asn Tyr 
1               5                   10                  15      


<210>  54
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  54

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser 
            20                  25                  30  


<210>  55
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  FR2

<400>  55

Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  15  


<210>  56
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  56

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Leu Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr Lys 
            20                  25                  30          


<210>  57
<211>  11
<212>  PRT
<213>  ˹

<220>
<223>  FR4

<400>  57

Gly Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      


<210>  58
<211>  4
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  58

Asn Tyr Ala Met 
1               


<210>  59
<211>  16
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  59

Arg Ile Ser Ser Ser Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  60
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  60

Ser Ser Glu Ala Pro 
1               5   


<210>  61
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  61

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Tyr Arg 
            20                  25                  30  


<210>  62
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  62

Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  63
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  63

Gly Asn Tyr Met Gly 
1               5   


<210>  64
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  64

Ala Ile Ala Thr Asn Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  65
<211>  19
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  65

Asp Asn Ser Trp Ser Cys Thr Val Val Gly Gly Leu Leu Ala Pro Ala 
1               5                   10                  15      


Tyr Asn Tyr 
            


<210>  66
<211>  30
<212>  PRT
<213>  ˹

<220>
<223>  FR1

<400>  66

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Tyr Ser 
            20                  25                  30  


<210>  67
<211>  32
<212>  PRT
<213>  ˹

<220>
<223>  FR3

<400>  67

Arg Phe Thr Ile Ser Leu Asp Ile Ala Lys Lys Thr Leu Ser Leu Gln 
1               5                   10                  15      


Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Ala 
            20                  25                  30          


<210>  68
<211>  5
<212>  PRT
<213>  ˹

<220>
<223>  CDR1

<400>  68

Trp Tyr Cys Met Gly 
1               5   


<210>  69
<211>  17
<212>  PRT
<213>  ˹

<220>
<223>  CDR2

<400>  69

Ala Ile Cys Thr Thr Pro Ser Arg Thr Tyr Ala Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  70
<211>  18
<212>  PRT
<213>  ˹

<220>
<223>  CDR3

<400>  70

Asp Thr Arg Gly Ala Ile Gly Phe Phe Lys Gly Ser Gly Pro Ala Ile 
1               5                   10                  15      


Pro Tyr 
        


<210>  71
<211>  123
<212>  PRT
<213>  ˹

<220>
<223>  1#׿

<400>  71

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Val Ala His Arg Arg Tyr 
            20                  25                  30          


Tyr Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ser Ile Tyr Ile Gly Ser Gly Ser Thr Asp Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Asn Asp Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Leu Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Leu Tyr Gly Gly Arg Trp Asp Arg Ala Gln Tyr Lys Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  131
<212>  PRT
<213>  ˹

<220>
<223> 2#׿

<400>  72

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Arg Ser Thr Ile 
            20                  25                  30          


Trp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Ile Gly Ser Gly Ala Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Thr Gly Gly Thr Val Gly Ser Met Val Arg Phe 
            100                 105                 110         


Ser Pro Val Gly Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  73
<211>  123
<212>  PRT
<213>  ˹

<220>
<223> 3#׿

<400>  73

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asn Ser Asp Gly Gly Thr Tyr Tyr Ser Asn Ser Val Lys 
    50                  55                  60                  


Gly Arg Ser Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Leu Glu Thr Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Lys Gly Asn Gly Pro Ser Trp Thr Leu Gly Ser Val Asp Val Asn Ser 
            100                 105                 110         


Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  74
<211>  126
<212>  PRT
<213>  ˹

<220>
<223> 4#׿

<400>  74

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Asp Thr Tyr Arg Arg Asn 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Thr Gly Gly Thr Ser Thr Ala Tyr Ala Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Gln Asp Ser Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Val Trp Ser Arg Tyr Thr Trp Ser Trp Pro Ser Thr 
            100                 105                 110         


Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  75
<211>  124
<212>  PRT
<213>  ˹

<220>
<223> 5#׿

<400>  75

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Glu Tyr Ser Tyr Ser Arg Lys 
            20                  25                  30          


Trp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Thr Ser Gly Arg Thr Ala Val Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Gln Asp Ile Ala Glu Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Arg Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Leu Thr Gly Ala Ser Asp Ser Pro Leu Arg Pro Ser Glu Tyr Asn 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  76
<211>  130
<212>  PRT
<213>  ˹

<220>
<223> 6#׿

<400>  76

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asn Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Gly Ser Ser Leu Ala Val Gly Ala Trp Leu Lys Ala 
            100                 105                 110         


Ala Asp Pro Phe Tyr Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  77
<211>  131
<212>  PRT
<213>  ˹

<220>
<223> 7#׿

<400>  77

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Tyr Thr Arg Ser Thr Ile 
            20                  25                  30          


Trp Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Ile Gly Ser Gly Ala Thr Tyr Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Ala Lys Asn 
65                  70                  75                  80  


Thr Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Met 
                85                  90                  95      


Tyr Tyr Cys Ala Ala Thr Ser Gly Thr Val Gly Ser Met Val Arg Phe 
            100                 105                 110         


Ser Pro Val Gly Asp Phe Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             


Val Ser Ser 
    130     


<210>  78
<211>  115
<212>  PRT
<213>  ˹

<220>
<223> 8#׿

<400>  78

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Val 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Phe Gly Ser Gly Gly Glu Ser Pro Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Lys Met Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Arg Trp Ala Glu Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  79
<211>  124
<212>  PRT
<213>  ˹

<220>
<223> 9#׿

<400>  79

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Leu Phe Ser Arg Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Thr Asn Gly Gly Ser Ile Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Thr 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Ala Gly Glu Tyr Gly Pro Val Ser Asp Tyr Val Phe Ser 
            100                 105                 110         


Leu Arg Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  80
<211>  125
<212>  PRT
<213>  ˹

<220>
<223> 10#׿

<400>  80

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Ile Gly Ser Asn 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Tyr Thr Gly Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ala Ile Ser Glu Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Leu Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Leu Arg Leu Arg Val Ala Val Leu His Pro Tyr Gly Tyr 
            100                 105                 110         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  81
<211>  113
<212>  PRT
<213>  ˹

<220>
<223> 11#׿

<400>  81

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser Ser Gly Ile Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Lys Ser Ser Glu Ala Pro Gly Gly Gln Gly Thr Gln Val Thr Val Ser 
            100                 105                 110         


Ser 
    


<210>  82
<211>  128
<212>  PRT
<213>  ˹

<220>
<223> 12#׿

<400>  82

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ala Ile Tyr Arg Gly Asn 
            20                  25                  30          


Tyr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Ala Thr Asn Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Gln Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Asp Leu Lys Pro Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Asn Ser Trp Ser Cys Thr Val Val Gly Gly Leu Leu Ala 
            100                 105                 110         


Pro Ala Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  83
<211>  127
<212>  PRT
<213>  ˹

<220>
<223> 13#׿

<400>  83

Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Arg Phe Thr Tyr Ser Trp Tyr 
            20                  25                  30          


Cys Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Cys Thr Thr Pro Ser Arg Thr Tyr Ala Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Leu Asp Ile Ala Lys Lys Thr Leu Ser 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Thr Arg Gly Ala Ile Gly Phe Phe Lys Gly Ser Gly Pro 
            100                 105                 110         


Ala Ile Pro Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  84
<211>  369
<212>  DNA
<213>  ˹

<220>
<223>  1#׿DNA

<400>  84
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggtgt cgcccacagg cgctactaca tgtcctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcatcc atttatattg gtagtggtag cacagactat      180

gtcgactccg tgaagggccg attcaccatc tcccaagaca acgccaacga catggtgtat      240

ctgcaaatgc tcagcctcaa acctgaggac actgccatgt actactgtgc ggcaggcctt      300

tacggtggta gatgggatcg ggcccagtat aagtactggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  85
<211>  393
<212>  DNA
<213>  ˹

<220>
<223>  2#׿DNA

<400>  85
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtacag cctccggata cacccgcagt accatttgga taggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcagct atttatattg gtagtggcgc gacatactat      180

gtggactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cgccaagaac      240

acggtgtatc tgcagatgaa cagcctgaaa cctgaggaca ctgccatgta ctactgtgcg      300

gcaacgggcg gtactgtagg aagtatggtc cgattctccc cagtgggcga ctttggttat      360

tggggccagg ggacccaggt caccgtctcc tca                                   393


<210>  86
<211>  369
<212>  DNA
<213>  ˹

<220>
<223>  3#׿DNA

<400>  86
gatgtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt caccttcaca aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg gactcgagtg ggtctcaggt attaatagtg atggtggcac atactattca      180

aactccgtga agggccgaag caccatctcc agagacaacg ccaagaacac gctgtatctg      240

caattgaaca gcctggagac tgaggacacg gccatgtatt actgtgcaaa aggaaacggc      300

ccgtcttgga ccctggggag cgtggacgtt aactcccggg gccaggggac ccaggtcacc      360

gtctcctca                                                              369


<210>  87
<211>  378
<212>  DNA
<213>  ˹

<220>
<223>  4#׿DNA

<400>  87
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggaga cacttacagg cgcaacacca tgggctggtt ccgccaggct      120

ccggggaagg agcgcgaggg ggtcgcagct atttatactg gtggtactag tacagcctat      180

gccgactccg tgaggggccg attcaccatc tcccaagaca gcgccaagaa cacggtgtat      240

ctgcaaatga acagcctgaa acctgaggac actgccatat actactgtgc ggcaggctca      300

gtgtggtccc gttatacatg gtcctggccc agtacgtata gctactgggg ccaggggacc      360

caggtcaccg tctcctca                                                    378


<210>  88
<211>  372
<212>  DNA
<213>  ˹

<220>
<223>  5#׿DNA

<400>  88
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctgaata cagctacagt aggaagtgga tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcagct atttatacta gtggtaggac agccgttgcc      180

gactccgtga agggccgatt caccatctcc caagacatcg ccgagaacac ggtgtatctg      240

cgtatgaaca gcctgaaacc tgaggacact gccatgtact actgtgcggc actcacaggt      300

gctagcgact caccgctacg cccaagcgag tataactact ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  89
<211>  390
<212>  DNA
<213>  ˹

<220>
<223>  6#׿DNA

<400>  89
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggatt cacattcagt agctacgaca tgagctgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcagct attaatagtg gtggtggtag cacatactat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacgatgtat      240

ctgcaaatga acagcctgaa acctgaggac actgccatgt actactgtgc ggcagatcct      300

ggttcaagtt tggcggtggg agcttggttg aaggcggcgg atcccttcta tggttactgg      360

ggccagggga cccaggtcac cgtctcctca                                       390


<210>  90
<211>  393
<212>  DNA
<213>  ˹

<220>
<223>  7#׿DNA

<400>  90
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtacag cctccggata cacccgcagt accatttgga taggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcagct atttatattg gtagtggcgc gacatactat      180

gtggactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cgccaagaac      240

acggtgtatc tgcagatgaa cagcctgaaa cctgaggaca ctgccatgta ctactgtgcg      300

gcaacgagcg gtactgtagg aagtatggtc cgattctccc cagtgggcga ctttggttat      360

tggggccagg ggacccaggt caccgtctcc tca                                   393


<210>  91
<211>  345
<212>  DNA
<213>  ˹

<220>
<223>  8#׿DNA

<400>  91
gatgtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cacattcagt ggcgtcgaca tgagctgggt ccgccaggct      120

ccagggaggg ggctcgagtg ggtctcaggg tttggtagtg gtggtgaaag cccatcatat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa aatgctgtat      240

ctgcagatgg acagtttgaa acctgaggac acagccgtgt attactgcgc cacccgctgg      300

gctgagggct actggggcca ggggacccag gtcaccgtct cctca                      345


<210>  92
<211>  372
<212>  DNA
<213>  ˹

<220>
<223>  9#׿DNA

<400>  92
gatgtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag cctctggatt cctcttcagt agatattcca tgagttgggt ccgccaggct      120

ccagggaagg gactcgagtg ggtctcaggt attacgaatg gtggtagcat tacaaagtat      180

gcagactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacactgact      240

ctgcaactga acagcctgaa aactgaggac acggccatgt attactgtgc caaaggcgcg      300

ggggagtatg gccctgttag tgactatgtc ttctctctca ggggccaggg gacccaggtc      360

accgtctcct ca                                                          372


<210>  93
<211>  375
<212>  DNA
<213>  ˹

<220>
<223>  10#׿DNA

<400>  93
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggata caccatcggt agcaactaca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcagct atttatactg gtggtggtaa tacatactat      180

gccgactccg tgaagggccg attcgccatc tccgaagaca acgccaagaa cacggtgtat      240

ctgcacatga acctcctgaa acctgaggac actgccatgt actactgtgc ggcagacttg      300

agactacggg ttgctgtact ccacccgtat gggtataact actggggcca ggggacccag      360

gtcaccgtct cctca                                                       375


<210>  94
<211>  339
<212>  DNA
<213>  ˹

<220>
<223>  11#׿DNA

<400>  94
gatgtgcagc tgcaggagtc tggaggaggc ttggtgcagc ctggggggtc tctgagactc       60

tcctgtgcag tctctggatt caccttcagt aactatgcca tgagctgggt ccgccaggct      120

ccagggaagg ggctcgagtg ggtctcacgt attagtagta gtggtattac atactatgca      180

gactccgtga agggccgatt caccatctcc agagacaacg ccaagaacac gctgtatcta      240

caattgaaca acctgaaaac tgaggacacg gccatgtatt actgtacaaa aagttccgag      300

gccccgggtg gccaggggac ccaggtcacc gtctcctca                             339


<210>  95
<211>  384
<212>  DNA
<213>  ˹

<220>
<223>  12#׿DNA

<400>  95
gatgtgcagc tgcaggagtc tggaggaggc tcggtacagg ctggagggtc tctgagactc       60

tcctgtgcag cctctggagc catctacaga ggcaactaca tgggctggtt ccgccaggct      120

ccagggaagg agcgcgaggg ggtcgcggct atcgctacta atggtcgtac aacatactat      180

gccgactccg tgaagggccg attcaccatc tcccaagaca acgccaagaa cacggtgtat      240

ctgcaaatga acgacctgaa acctgaggac actgccatgt actactgtgc ggcagacaac      300

tcttggtcct gtacggtggt aggtgggcta ctggcgcctg cctataacta ctggggccag      360

gggacccagg tcaccgtctc ctca                                             384


<210>  96
<211>  381
<212>  DNA
<213>  ˹

<220>
<223>  13#׿DNA

<400>  96
gatgtgcagc tgcaggagtc tggaggaggc tcggtgcagg ctggagggtc tctgagactc       60

tcctgtgcag cctctagatt tacctacagt tggtactgca tgggctggtt ccgccaggct      120

ccggggaagg agcgcgaggg ggtcgcagct atttgcacga caccgagccg cacatacgct      180

gccgactccg tgaagggtcg attcaccatc tccctagaca tcgccaagaa gacgctgtct      240

ctgcaaatgg acagcctgaa atctgaggac actgccatgt actactgtgc ggcagataca      300

agaggagcta tagggttctt caagggcagt gggcccgcca tcccctactg gggccagggg      360

acccaggtca ccgtctcctc a                                                381


