                         SEQUENCE LISTING

<110>  NANJING LEADS BIOLABS CO., LTD.
 
<120>  ANTIBODIES BINDING 4-1BB AND USES THEREOF

<130>  PF 200331PCT

<150>  US 62/913,744
<151>  2019-10-11

<160>  85    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  1

Ser Tyr Ala Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  2

Val Ile Ser Tyr Asp Gly Ser Lys Lys Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  3

Asn Gln Gly Ser Gly Ser Tyr Leu Tyr Tyr Tyr Tyr Met Asp Val 
1               5                   10                  15  


<210>  4
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  4

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  5
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  5

Glu Val Ser Asn Arg Pro Ser 
1               5           


<210>  6
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  6

Ser Ser Tyr Thr Ser Ser Ser Thr Phe Tyr Val 
1               5                   10      


<210>  7
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  7

Ser Tyr Ala Ile Ser 
1               5   


<210>  8
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  8

Gly Ile Ile Pro Ile Ser Gly Ala Val Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  9
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  9

Asp Gln Phe Ile Lys Tyr Tyr Asp Phe Ser Ser Gly Tyr Phe Pro Asn 
1               5                   10                  15      


Gly Phe Asp Ile 
            20  


<210>  10
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  10

Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala Ala 
1               5                   10      


<210>  11
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  11

Gln Asp Thr Val Arg Pro Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  12

Gln Thr Trp Val Ser Ser Thr Gly Val 
1               5                   


<210>  13
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  13

Ser Tyr Tyr Met His 
1               5   


<210>  14
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  14

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  15
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  15

Asp Leu Gly Glu Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr Pro Ser 
1               5                   10                  15      


Gly Ala Phe Asp Ile 
            20      


<210>  16
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  16

Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10                  


<210>  17
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  17

Asp Val Thr Thr Arg Pro Ser 
1               5           


<210>  18
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  18

Ser Ser Tyr Thr Ser Tyr Ser Thr Trp Val 
1               5                   10  


<210>  19
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  19

Ser Ser His Trp Trp Ser 
1               5       


<210>  20
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  20

Glu Ile Tyr His Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  21
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  21

Glu Asp Gly Gly Ile Met Asp Val 
1               5               


<210>  22
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  22

Gln Gly Asp Ser Leu Arg Arg Phe Tyr Ala Ser 
1               5                   10      


<210>  23
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  23

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  24
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  24

Ser Ser Arg Asp Arg Ser Gly Tyr Arg Trp Val 
1               5                   10      


<210>  25
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  25

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gln Gly Ser Gly Ser Tyr Leu Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  26
<211>  112
<212>  PRT
<213>  Artificial

<220>
<223>  construct


<220>
<221>  misc_feature
<222>  (112)..(112)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Phe Tyr Val Phe Gly Thr Gly Thr Gln Leu Thr Val Leu Xaa 
            100                 105                 110         


<210>  27
<211>  129
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  27

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Ser Gly Ala Val Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Gln Phe Ile Lys Tyr Tyr Asp Phe Ser Ser Gly Tyr Phe 
            100                 105                 110         


Pro Asn Gly Phe Asp Ile Trp Gly Lys Gly Thr Leu Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  28
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  28

Gln Thr Val Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Lys Leu Gly Asp Lys Tyr Ala 
            20                  25                  30          


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gln Asp Thr Val Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Val Ser Ser Thr Gly Val 
                85                  90                  95      


Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105         


<210>  29
<211>  130
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  29

Glu Val Gln Leu Val Glu Thr Gly Val Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Glu Gly Tyr Asp Phe Trp Ser Gly Tyr Tyr Thr 
            100                 105                 110         


Pro Ser Gly Ala Phe Asp Ile Trp Gly Lys Gly Thr Met Val Thr Val 
        115                 120                 125             


Ser Ser 
    130 


<210>  30
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  30

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Arg Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Thr Thr Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Tyr 
                85                  90                  95      


Ser Thr Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110     


<210>  31
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  31

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Pro Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Gly Ser Ile Ser Ser Ser 
            20                  25                  30          


His Trp Trp Ser Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Glu Ile Tyr His Ser Gly Arg Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Asp Gly Gly Ile Met Asp Val Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  32
<211>  110
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  32

Leu Ser Ser Glu Leu Thr Gln Asp Pro Ala Val Ser Val Ala Leu Gly 
1               5                   10                  15      


Gln Thr Val Arg Ile Thr Cys Gln Gly Asp Ser Leu Arg Arg Phe Tyr 
            20                  25                  30          


Ala Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
        35                  40                  45              


Tyr Gly Lys Asn Asn Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ala 
    50                  55                  60                  


Ser Asp Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Ala Gln Ala 
65                  70                  75                  80  


Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Arg Asp Arg Ser Gly Tyr 
                85                  90                  95      


Arg Trp Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110 


<210>  33
<211>  326
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  33

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  34
<211>  330
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  34

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  35
<211>  105
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  35

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  36
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  36

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  37
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  37

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Ser Gly Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn His Gly Gly Tyr Val Thr Tyr Asn Pro Ser Leu Glu 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Pro Gly Asn Tyr Asp Trp Tyr Phe Asp Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly 
    210                 215                 220                 


Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445             


<210>  38
<211>  216
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  38

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Ala Leu Thr Phe Cys Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
            100                 105                 110         


Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys 
        115                 120                 125             


Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg 
    130                 135                 140                 


Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn 
145                 150                 155                 160 


Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser 
                165                 170                 175     


Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys 
            180                 185                 190         


Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr 
        195                 200                 205             


Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215     


<210>  39
<211>  255
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  39

Met Gly Asn Ser Cys Tyr Asn Ile Val Ala Thr Leu Leu Leu Val Leu 
1               5                   10                  15      


Asn Phe Glu Arg Thr Arg Ser Leu Gln Asp Pro Cys Ser Asn Cys Pro 
            20                  25                  30          


Ala Gly Thr Phe Cys Asp Asn Asn Arg Asn Gln Ile Cys Ser Pro Cys 
        35                  40                  45              


Pro Pro Asn Ser Phe Ser Ser Ala Gly Gly Gln Arg Thr Cys Asp Ile 
    50                  55                  60                  


Cys Arg Gln Cys Lys Gly Val Phe Arg Thr Arg Lys Glu Cys Ser Ser 
65                  70                  75                  80  


Thr Ser Asn Ala Glu Cys Asp Cys Thr Pro Gly Phe His Cys Leu Gly 
                85                  90                  95      


Ala Gly Cys Ser Met Cys Glu Gln Asp Cys Lys Gln Gly Gln Glu Leu 
            100                 105                 110         


Thr Lys Lys Gly Cys Lys Asp Cys Cys Phe Gly Thr Phe Asn Asp Gln 
        115                 120                 125             


Lys Arg Gly Ile Cys Arg Pro Trp Thr Asn Cys Ser Leu Asp Gly Lys 
    130                 135                 140                 


Ser Val Leu Val Asn Gly Thr Lys Glu Arg Asp Val Val Cys Gly Pro 
145                 150                 155                 160 


Ser Pro Ala Asp Leu Ser Pro Gly Ala Ser Ser Val Thr Pro Pro Ala 
                165                 170                 175     


Pro Ala Arg Glu Pro Gly His Ser Pro Gln Ile Ile Ser Phe Phe Leu 
            180                 185                 190         


Ala Leu Thr Ser Thr Ala Leu Leu Phe Leu Leu Phe Phe Leu Thr Leu 
        195                 200                 205             


Arg Phe Ser Val Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe 
    210                 215                 220                 


Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
                245                 250                 255 


<210>  40
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  40

Ser Gly Tyr Trp Asn 
1               5   


<210>  41
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  41

Tyr Val Ser Tyr Thr Gly Ser Thr Tyr Tyr Ile Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  42
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  42

Tyr Arg Asp Trp Leu His Gly Tyr Phe Asp Tyr 
1               5                   10      


<210>  43
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  43

Lys Ala Ser Gln Asn Val Met Asp Asn Val Ala 
1               5                   10      


<210>  44
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  44

Ser Ala Ser Tyr Arg Phe Ser 
1               5           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  45

Gln Gln Tyr Asn Gly Tyr Pro Leu Thr 
1               5                   


<210>  46
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  46

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Val Ser Tyr Thr Gly Ser Thr Tyr Tyr Ile Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Tyr Arg Asp Trp Leu His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  47
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  47

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Met Asp Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  48
<211>  704
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  48

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gln Gly Ser Gly Ser Tyr Leu Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser Ser 
        115                 120                 125             


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
145                 150                 155                 160 


Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val Ile Ile Tyr Glu Val 
            180                 185                 190         


Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Val Gln Ser Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Phe Tyr Val 
225                 230                 235                 240 


Phe Gly Cys Gly Thr Gln Leu Thr Val Leu Gly Gly Gly Gly Ser Glu 
                245                 250                 255     


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln Thr 
            260                 265                 270         


Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Ser Ser Gly Tyr 
        275                 280                 285             


Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile Gly 
    290                 295                 300                 


Tyr Val Ser Tyr Thr Gly Ser Thr Tyr Tyr Ile Pro Ser Leu Lys Ser 
305                 310                 315                 320 


Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys 
                325                 330                 335     


Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Gly 
            340                 345                 350         


Tyr Arg Asp Trp Leu His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    370                 375                 380                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
385                 390                 395                 400 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                405                 410                 415     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            420                 425                 430         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        435                 440                 445             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    450                 455                 460                 


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
465                 470                 475                 480 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser 
                485                 490                 495     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            500                 505                 510         


Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro 
        515                 520                 525             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    530                 535                 540                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
545                 550                 555                 560 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                565                 570                 575     


Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys Thr 
            580                 585                 590         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        595                 600                 605             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    610                 615                 620                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
625                 630                 635                 640 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                645                 650                 655     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            660                 665                 670         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        675                 680                 685             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    690                 695                 700                 


<210>  49
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  49

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Met Asp Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Tyr Arg Phe Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Gly Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  50
<211>  714
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  50

Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Phe Ser Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln His Pro Gly Lys Gly Leu Glu Tyr Ile 
        35                  40                  45              


Gly Tyr Val Ser Tyr Thr Gly Ser Thr Tyr Tyr Ile Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Gly Tyr Arg Asp Trp Leu His Gly Tyr Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
465                 470                 475                 480 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
                485                 490                 495     


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
            500                 505                 510         


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Trp Tyr Ala Asp Ser Val 
        515                 520                 525             


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
    530                 535                 540                 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
545                 550                 555                 560 


Ala Arg Asn Gln Gly Ser Gly Ser Tyr Leu Tyr Tyr Tyr Tyr Met Asp 
                565                 570                 575     


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser Gly Ser Ser Ser 
            580                 585                 590         


Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gln Ser Ala Leu Thr 
        595                 600                 605             


Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln Ser Val Thr Ile Ser 
    610                 615                 620                 


Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Tyr Val Ser Trp 
625                 630                 635                 640 


Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val Ile Ile Tyr Glu Val 
                645                 650                 655     


Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe Ser Gly Ser Lys Ser 
            660                 665                 670         


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Val Gln Ser Glu Asp Glu 
        675                 680                 685             


Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser Ser Thr Phe Tyr Val 
    690                 695                 700                 


Phe Gly Cys Gly Thr Gln Leu Thr Val Leu 
705                 710                 


<210>  51
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  51

Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Ser Ser 
1               5                   10                  15  


<210>  52
<211>  5
<212>  PRT
<213>  Artificial

<220>
<221> REPEAT
<222> (Gly-Gly-Gly-Gly-Ser) repeated for 1, 2, 3, 4, 5, or 6 times
<223>  construct

<400>  52

Gly Gly Gly Gly Ser 
1               5   


<210>  53
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  53
tccggctact ggaac                                                      15


<210>  54
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  54
tacgtgtcct acaccggctc tacctactac atccccagcc tgaagtcc                  48


<210>  55
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  55
tacagagatt ggctgcacgg ctacttcgac tac                                  33


<210>  56
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  56
aaggccagcc agaacgtgat ggacaacgtg gcc                                  33


<210>  57
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  57
tccgcctcct acagattctc t                                               21


<210>  58
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  58
cagcagtaca acggctaccc tctgacc                                         27


<210>  59
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  59
gaggtccagc tgcaagaatc tggccctgga ctggtcaagc cctctcagac cctgtctctg     60

acctgtaccg tgtccggcga ctccttctct tccggctact ggaactggat cagacagcac    120

cctggcaagg gcctcgagta catcggctac gtgtcctaca ccggctctac ctactacatc    180

cccagcctga agtccagagt gaccatctct cgggacacct ccaagaacca gttctccctg    240

aagctgtcct ccgtgaccgc tgctgatacc gccgtgtact actgtgccgg ctacagagat    300

tggctgcacg gctacttcga ctactggggc cagggcacaa cagtgaccgt ttcttct       357


<210>  60
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  60
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc     60

atcacatgca aggccagcca gaacgtgatg gacaacgtgg cctggtatca gcagaagcct    120

ggcaaggccc ctaagcggct gatctactcc gcctcctaca gattctctgg cgtgccctct    180

agattctccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct    240

gaggacttcg ccacctacta ctgccagcag tacaacggct accctctgac ctttggccag    300

ggcaccaagc tggaaatcaa g                                              321


<210>  61
<211>  290
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  61

Met Arg Ile Phe Ala Val Phe Ile Phe Met Thr Tyr Trp His Leu Leu 
1               5                   10                  15      


Asn Ala Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr 
            20                  25                  30          


Gly Ser Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu 
        35                  40                  45              


Asp Leu Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile 
    50                  55                  60                  


Ile Gln Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser 
65                  70                  75                  80  


Tyr Arg Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn 
                85                  90                  95      


Ala Ala Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr 
            100                 105                 110         


Arg Cys Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val 
        115                 120                 125             


Lys Val Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val 
    130                 135                 140                 


Asp Pro Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr 
145                 150                 155                 160 


Pro Lys Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser 
                165                 170                 175     


Gly Lys Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn 
            180                 185                 190         


Val Thr Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr 
        195                 200                 205             


Cys Thr Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu 
    210                 215                 220                 


Val Ile Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg Thr His 
225                 230                 235                 240 


Leu Val Ile Leu Gly Ala Ile Leu Leu Cys Leu Gly Val Ala Leu Thr 
                245                 250                 255     


Phe Ile Phe Arg Leu Arg Lys Gly Arg Met Met Asp Val Lys Lys Cys 
            260                 265                 270         


Gly Ile Gln Asp Thr Asn Ser Lys Lys Gln Ser Asp Thr His Leu Glu 
        275                 280                 285             


Glu Thr 
    290 


<210>  62
<211>  870
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  62
atgaggatat ttgctgtctt tatattcatg acctactggc atttgctgaa cgcatttact     60

gtcacggttc ccaaggacct atatgtggta gagtatggta gcaatatgac aattgaatgc    120

aaattcccag tagaaaaaca attagacctg gctgcactaa ttgtctattg ggaaatggag    180

gataagaaca ttattcaatt tgtgcatgga gaggaagacc tgaaggttca gcatagtagc    240

tacagacaga gggcccggct gttgaaggac cagctctccc tgggaaatgc tgcacttcag    300

atcacagatg tgaaattgca ggatgcaggg gtgtaccgct gcatgatcag ctatggtggt    360

gccgactaca agcgaattac tgtgaaagtc aatgccccat acaacaaaat caaccaaaga    420

attttggttg tggatccagt cacctctgaa catgaactga catgtcaggc tgagggctac    480

cccaaggccg aagtcatctg gacaagcagt gaccatcaag tcctgagtgg taagaccacc    540

accaccaatt ccaagagaga ggagaagctt ttcaatgtga ccagcacact gagaatcaac    600

acaacaacta atgagatttt ctactgcact tttaggagat tagatcctga ggaaaaccat    660

acagctgaat tggtcatccc agaactacct ctggcacatc ctccaaatga aaggactcac    720

ttggtaattc tgggagccat cttattatgc cttggtgtag cactgacatt catcttccgt    780

ttaagaaaag ggagaatgat ggatgtgaaa aaatgtggca tccaagatac aaactcaaag    840

aagcaaagtg atacacattt ggaggagacg                                     870


<210>  63
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  63

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  64
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  64
cggacggtgg ctgcaccatc tgtcttcatc ttcccgccat ctgatgagca gttgaaatct     60

ggaactgcct ctgttgtgtg cctgctgaat aacttctacc ccagagaagc caaagtgcag    120

tggaaggtgg acaacgccct gcagagcgga aacagccagg aaagcgtgac agagcaggat    180

tccaaggatt ccacatacag cctgagcagc acactgacac tgtccaaggc cgactacgag    240

aagcacaagg tgtacgcctg cgaagtgaca caccagggac tgtcctcccc tgtgacaaag    300

agcttcaaca gaggagaatg c                                              321


<210>  65
<211>  2112
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  65
caggtgcagc tgcaggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg     60

agctgcgccg tgtctggctt caccttttcc agctacgcca tgcactgggt gagacaggct    120

cctggcaagt gcctggagtg ggtggccgtg atctcctacg acggcagcaa gaagtggtat    180

gctgatagcg tgaagggcag gttcaccatc tctcgggaca actccaagaa tacactgtac    240

ctgcagatga actctctgag agccgaggat accgccgtgt actattgtgc tcgcaatcag    300

ggcagcggct cttatctgta ctattactat atggacgtgt ggggcaaggg caccacagtg    360

acagtgtctt ccggctcctc cagctctggc agttctagct ctggctctag ctccagccag    420

tccgccctga cccagcctag gtccgtgtcc ggaagccctg gccagtccgt gaccatctcc    480

tgtacaggca cctcctccga cgtgggcggc tacaactacg tgagctggta ccagcagctg    540

cccggcaagg ctcccaaggt gatcatctac gaggtgtcca acaggccctc cggcgtgtcc    600

aataggttca gcggctccaa gtccggaaac accgcctccc tgaccatcag cggcgtgcag    660

tccgaggatg aggccgacta ctactgctcc tcctacacct ccagctccac cttctacgtg    720

ttcggctgcg gcacccagct gaccgtgctg ggtggcggag gatctgaggt ccagctgcaa    780

gaatctggcc ctggactggt caagccctct cagaccctgt ctctgacctg taccgtgtcc    840

ggcgactcct tctcttccgg ctactggaac tggatcagac agcaccctgg caagggcctc    900

gagtacatcg gctacgtgtc ctacaccggc tctacctact acatccccag cctgaagtcc    960

agagtgacca tctctcggga cacctccaag aaccagttct ccctgaagct gtcctccgtg   1020

accgctgctg ataccgccgt gtactactgt gccggctaca gagattggct gcacggctac   1080

ttcgactact ggggccaggg cacaacagtg accgtttctt ctgccagcac caagggacca   1140

tccgtgttcc cactggcccc ctccagcaag tccaccagcg gaggaacagc cgctctggga   1200

tgcctggtga aggactactt cccagagccc gtgacagtga gctggaactc tggcgccctg   1260

accagcggag tgcacacatt tcccgccgtg ctccagtctt ccggcctgta ctctctgagc   1320

tctgtggtga ccgtgccctc cagctctctg ggcacccaga catatatctg caacgtgaat   1380

cacaagccaa gcaatacaaa ggtggacaag aaggtggagc ccaagtcttg tgataagacc   1440

catacatgcc ccccttgtcc tgctccagag gctgctggag gaccaagcgt gttcctgttt   1500

ccacccaagc ctaaggacac cctgatgatc tccaggaccc ccgaggtgac atgcgtggtg   1560

gtggctgtga gccacgagga ccccgaggtg aagtttaact ggtacgtgga tggcgtggag   1620

gtgcataatg ctaagaccaa gcctagggag gagcagtaca actctaccta tcgggtggtg   1680

tccgtgctga cagtgctgca ccaggactgg ctgaacggca aggagtataa gtgcaaggtg   1740

tctaataagg ccctggctgc tcctatcgag aagaccatct ccaaggccaa gggccagcct   1800

agagagccac aggtgtacac actgcctcca tctcgcgacg agctgaccaa gaaccaggtg   1860

tccctgacat gtctggtgaa gggcttctat ccttccgaca tcgctgtgga gtgggagagc   1920

aacggccagc cagagaacaa ttacaagacc acaccccctg tgctggactc cgatggcagc   1980

ttctttctgt atagcaagct gaccgtggat aagtccaggt ggcagcaggg caacgtgttt   2040

tcttgctccg tgatgcatga ggctctgcac aatcattata cacagaagag cctgtctctg   2100

tcccctggca ag                                                       2112


<210>  66
<211>  2142
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  66
gaggtccagc tgcaagaatc tggccctgga ctggtcaagc cctctcagac cctgtctctg     60

acctgtaccg tgtccggcga ctccttctct tccggctact ggaactggat cagacagcac    120

cctggcaagg gcctcgagta catcggctac gtgtcctaca ccggctctac ctactacatc    180

cccagcctga agtccagagt gaccatctct cgggacacct ccaagaacca gttctccctg    240

aagctgtcct ccgtgaccgc tgctgatacc gccgtgtact actgtgccgg ctacagagat    300

tggctgcacg gctacttcga ctactggggc cagggcacaa cagtgaccgt ttcttctgcc    360

agcaccaagg gaccatccgt gttcccactg gccccctcca gcaagtccac cagcggagga    420

acagccgctc tgggatgcct ggtgaaggac tacttcccag agcccgtgac agtgagctgg    480

aactctggcg ccctgaccag cggagtgcac acatttcccg ccgtgctcca gtcttccggc    540

ctgtactctc tgagctctgt ggtgaccgtg ccctccagct ctctgggcac ccagacatat    600

atctgcaacg tgaatcacaa gccaagcaat acaaaggtgg acaagaaggt ggagcccaag    660

tcttgtgata agacccatac atgcccccct tgtcctgctc cagaggctgc tggaggacca    720

agcgtgttcc tgtttccacc caagcctaag gacaccctga tgatctccag gacccccgag    780

gtgacatgcg tggtggtggc tgtgagccac gaggaccccg aggtgaagtt taactggtac    840

gtggatggcg tggaggtgca taatgctaag accaagccta gggaggagca gtacaactct    900

acctatcggg tggtgtccgt gctgacagtg ctgcaccagg actggctgaa cggcaaggag    960

tataagtgca aggtgtctaa taaggccctg gctgctccta tcgagaagac catctccaag   1020

gccaagggcc agcctagaga gccacaggtg tacacactgc ctccatctcg cgacgagctg   1080

accaagaacc aggtgtccct gacatgtctg gtgaagggct tctatccttc cgacatcgct   1140

gtggagtggg agagcaacgg ccagccagag aacaattaca agaccacacc ccctgtgctg   1200

gactccgatg gcagcttctt tctgtatagc aagctgaccg tggataagtc caggtggcag   1260

cagggcaacg tgttttcttg ctccgtgatg catgaggctc tgcacaatca ttatacacag   1320

aagagcctgt ctctgtcccc tggcaagggt ggcggaggat ctggcggagg cggaagtggc   1380

ggtggcggtt cacaggtgca gctgcaggag tccggaggag gactggtgca gccaggaggc   1440

tccctgaggc tgagctgcgc cgtgtctggc ttcacctttt ccagctacgc catgcactgg   1500

gtgagacagg ctcctggcaa gtgcctggag tgggtggccg tgatctccta cgacggcagc   1560

aagaagtggt atgctgatag cgtgaagggc aggttcacca tctctcggga caactccaag   1620

aatacactgt acctgcagat gaactctctg agagccgagg ataccgccgt gtactattgt   1680

gctcgcaatc agggcagcgg ctcttatctg tactattact atatggacgt gtggggcaag   1740

ggcaccacag tgacagtgtc ttccggctcc tccagctctg gcagttctag ctctggctct   1800

agctccagcc agtccgccct gacccagcct aggtccgtgt ccggaagccc tggccagtcc   1860

gtgaccatct cctgtacagg cacctcctcc gacgtgggcg gctacaacta cgtgagctgg   1920

taccagcagc tgcccggcaa ggctcccaag gtgatcatct acgaggtgtc caacaggccc   1980

tccggcgtgt ccaataggtt cagcggctcc aagtccggaa acaccgcctc cctgaccatc   2040

agcggcgtgc agtccgagga tgaggccgac tactactgct cctcctacac ctccagctcc   2100

accttctacg tgttcggctg cggcacccag ctgaccgtgc tg                      2142


<210>  67
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  67
agctacgcca tgcac                                                      15


<210>  68
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  68
tacgacggca gcaagaagtg gtatgctgat agcgtgaagg gc                        42


<210>  69
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  69
aatcagggca gcggctctta tctgtactat tactatatgg acgtg                     45


<210>  70
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  70
acaggcacct cctccgacgt gggcggctac aactacgtga gc                        42


<210>  71
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  71
gaggtgtcca acaggccctc c                                               21


<210>  72
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  72
tcctcctaca cctccagctc caccttctac gtg                                  33


<210>  73
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  73
caggtgcagc tgcaggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg     60

agctgcgccg tgtctggctt caccttttcc agctacgcca tgcactgggt gagacaggct    120

cctggcaagg gactggagtg ggtggccgtg atctcctacg acggcagcaa gaagtggtat    180

gctgatagcg tgaagggcag gttcaccatc tctcgggaca actccaagaa tacactgtac    240

ctgcagatga actctctgag agccgaggat accgccgtgt actattgtgc tcgcaatcag    300

ggcagcggct cttatctgta ctattactat atggacgtgt ggggcaaggg caccacagtg    360

acagtgtctt cc                                                        372


<210>  74
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  74
caaagcgccc tgacccagcc taggtccgtg tccggaagcc ctggccagtc cgtgaccatc     60

tcctgtacag gcacctcctc cgacgtgggc ggctacaact acgtgagctg gtaccagcag    120

ctgcccggca aggctcccaa ggtgatcatc tacgaggtgt ccaacaggcc ctccggcgtg    180

tccaataggt tcagcggctc caagtccgga aacaccgcct ccctgaccat cagcggcgtg    240

cagtccgagg atgaggccga ctactactgc tcctcctaca cctccagctc caccttctac    300

gtgttcggca ccggcaccca gctgaccgtg ctg                                 333


<210>  75
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  75

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Lys 
                325         


<210>  76
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  76
gacatccaga tgacccagtc tccatcctct ctgtccgcct ctgtgggcga cagagtgacc     60

atcacatgca aggccagcca gaacgtgatg gacaacgtgg cctggtatca gcagaagcct    120

ggcaaggccc ctaagcggct gatctactcc gcctcctaca gattctctgg cgtgccctct    180

agattctccg gctctggctc tggcaccgag tttaccctga caatctccag cctgcagcct    240

gaggacttcg ccacctacta ctgccagcag tacaacggct accctctgac ctttggccag    300

ggcaccaagc tggaaatcaa gcggacggtg gctgcaccat ctgtcttcat cttcccgcca    360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctac    420

cccagagaag ccaaagtgca gtggaaggtg gacaacgccc tgcagagcgg aaacagccag    480

gaaagcgtga cagagcagga ttccaaggat tccacataca gcctgagcag cacactgaca    540

ctgtccaagg ccgactacga gaagcacaag gtgtacgcct gcgaagtgac acaccaggga    600

ctgtcctccc ctgtgacaaa gagcttcaac agaggagaat gc                       642


<210>  77
<211>  124
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Cys Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Ser Tyr Asp Gly Ser Lys Lys Trp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asn Gln Gly Ser Gly Ser Tyr Leu Tyr Tyr Tyr Tyr Met Asp 
            100                 105                 110         


Val Trp Gly Lys Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  78
<211>  111
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  78

Gln Ser Ala Leu Thr Gln Pro Arg Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val 
        35                  40                  45              


Ile Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Val 
65                  70                  75                  80  


Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Phe Tyr Val Phe Gly Cys Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  79
<211>  372
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  79
caggtgcagc tgcaggagtc cggaggagga ctggtgcagc caggaggctc cctgaggctg     60

agctgcgccg tgtctggctt caccttttcc agctacgcca tgcactgggt gagacaggct    120

cctggcaagt gcctggagtg ggtggccgtg atctcctacg acggcagcaa gaagtggtat    180

gctgatagcg tgaagggcag gttcaccatc tctcgggaca actccaagaa tacactgtac    240

ctgcagatga actctctgag agccgaggat accgccgtgt actattgtgc tcgcaatcag    300

ggcagcggct cttatctgta ctattactat atggacgtgt ggggcaaggg caccacagtg    360

acagtgtctt cc                                                        372


<210>  80
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  80
cagtccgccc tgacccagcc taggtccgtg tccggaagcc ctggccagtc cgtgaccatc     60

tcctgtacag gcacctcctc cgacgtgggc ggctacaact acgtgagctg gtaccagcag    120

ctgcccggca aggctcccaa ggtgatcatc tacgaggtgt ccaacaggcc ctccggcgtg    180

tccaataggt tcagcggctc caagtccgga aacaccgcct ccctgaccat cagcggcgtg    240

cagtccgagg atgaggccga ctactactgc tcctcctaca cctccagctc caccttctac    300

gtgttcggct gcggcaccca gctgaccgtg ctg                                 333


<210>  81
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  81

Leu Gln Asp Pro Cys Ser Asn Cys Pro Ala Gly Thr Phe Cys Asp Asn 
1               5                   10                  15      


Asn Arg Asn Gln Ile Cys Ser Pro Cys Pro Pro Asn Ser Phe Ser Ser 
            20                  25                  30          


Ala Gly Gly Gln Arg Thr Cys Asp Ile Cys Arg Gln Cys Lys Gly Val 
        35                  40                  45              


Phe Arg Thr Arg Lys Glu Cys Ser Ser Thr Ser Asn Ala Glu Cys Asp 
    50                  55                  60                  


Cys Thr Pro Gly Phe His Cys Leu Gly Ala Gly Cys Ser Met Cys Glu 
65                  70                  75                  80  


Gln Asp Cys Lys Gln Gly Gln Glu Leu Thr Lys Lys Gly Cys Lys Asp 
                85                  90                  95      


Cys Cys Phe Gly Thr Phe Asn Asp Gln Lys Arg Gly Ile Cys Arg Pro 
            100                 105                 110         


Trp Thr Asn Cys Ser Leu Asp Gly Lys Ser Val Leu Val Asn Gly Thr 
        115                 120                 125             


Lys Glu Arg Asp Val Val Cys Gly Pro Ser Pro Ala Asp Leu Ser Pro 
    130                 135                 140                 


Gly Ala Ser Ser Val Thr Pro Pro Ala Pro Ala Arg Glu Pro Gly His 
145                 150                 155                 160 


Ser Pro Gln Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
                165                 170                 175     


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
            180                 185                 190         


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
        195                 200                 205             


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
    210                 215                 220                 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
225                 230                 235                 240 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
                245                 250                 255     


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
            260                 265                 270         


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
        275                 280                 285             


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
    290                 295                 300                 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
305                 310                 315                 320 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
                325                 330                 335     


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
            340                 345                 350         


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
        355                 360                 365             


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
    370                 375                 380                 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
385                 390                 395 


<210>  82
<211>  446
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  82

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ala Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Val Ile Leu Tyr Asp Gly Ser Asp Lys Phe Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ala Val Ala Gly Thr His Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  83
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  83

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Leu Asn Ser Tyr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  84
<211>  466
<212>  PRT
<213>  Artificial

<220>
<223>  construct

<400>  84

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Ile Phe Ala Ile Lys 
            20                  25                  30          


Pro Ile Ser Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Trp Val 
        35                  40                  45              


Ser Thr Thr Thr Ser Ser Gly Ala Thr Asn Tyr Ala Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly 
            100                 105                 110         


Gly Ser Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Glu 
        115                 120                 125             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
    130                 135                 140                 


Ser Phe Ser Ile Asn Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys 
145                 150                 155                 160 


Arg Arg Glu Phe Val Ala Ala Ile Glu Ser Gly Arg Asn Thr Val Tyr 
                165                 170                 175     


Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
            180                 185                 190         


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
        195                 200                 205             


Val Tyr Tyr Cys Gly Leu Leu Lys Gly Asn Arg Val Val Ser Pro Ser 
    210                 215                 220                 


Val Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Lys Pro Gly Gly 
225                 230                 235                 240 


Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
            260                 265                 270         


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
        275                 280                 285             


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
    290                 295                 300                 


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
305                 310                 315                 320 


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
                325                 330                 335     


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
            340                 345                 350         


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
        355                 360                 365             


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
385                 390                 395                 400 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
            420                 425                 430         


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
        435                 440                 445             


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
    450                 455                 460                 


Gly Lys 
465     


<210>  85
<211>  990
<212>  DNA
<213>  Artificial

<220>
<223>  construct

<400>  85
gccagcacca agggaccatc cgtgttccca ctggccccct ccagcaagtc caccagcgga     60

ggaacagccg ctctgggatg cctggtgaag gactacttcc cagagcccgt gacagtgagc    120

tggaactctg gcgccctgac cagcggagtg cacacatttc ccgccgtgct ccagtcttcc    180

ggcctgtact ctctgagctc tgtggtgacc gtgccctcca gctctctggg cacccagaca    240

tatatctgca acgtgaatca caagccaagc aatacaaagg tggacaagaa ggtggagccc    300

aagtcttgtg ataagaccca tacatgcccc ccttgtcctg ctccagaggc tgctggagga    360

ccaagcgtgt tcctgtttcc acccaagcct aaggacaccc tgatgatctc caggaccccc    420

gaggtgacat gcgtggtggt ggctgtgagc cacgaggacc ccgaggtgaa gtttaactgg    480

tacgtggatg gcgtggaggt gcataatgct aagaccaagc ctagggagga gcagtacaac    540

tctacctatc gggtggtgtc cgtgctgaca gtgctgcacc aggactggct gaacggcaag    600

gagtataagt gcaaggtgtc taataaggcc ctggctgctc ctatcgagaa gaccatctcc    660

aaggccaagg gccagcctag agagccacag gtgtacacac tgcctccatc tcgcgacgag    720

ctgaccaaga accaggtgtc cctgacatgt ctggtgaagg gcttctatcc ttccgacatc    780

gctgtggagt gggagagcaa cggccagcca gagaacaatt acaagaccac accccctgtg    840

ctggactccg atggcagctt ctttctgtat agcaagctga ccgtggataa gtccaggtgg    900

cagcagggca acgtgttttc ttgctccgtg atgcatgagg ctctgcacaa tcattataca    960

cagaagagcc tgtctctgtc ccctggcaag                                     990


