                               SEQUENCE LISTING

<110> ZYMEWORKS INC.
      PROVINCIAL HEALTH SERVICES AUTHORITY
      UVIC INDUSTRY PARTNERSHIPS INC.
 
<120> MODIFIED EXTRACELLULAR DOMAIN OF GRANULOCYTE COLONY-STIMULATING 
      FACTOR RECEPTOR (G-CSFR) AND CYTOKINES BINDING SAME

<130> IKE-068WO

<140>
<141>

<150> 62/912,318
<151> 2019-10-08

<160> 90    

<170> PatentIn version 3.5

<210> 1
<211> 174
<212> PRT
<213> Homo sapiens

<400> 1
Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu Lys 
1               5                   10                  15      


Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu Gln 
            20                  25                  30          


Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu Val 
        35                  40                  45              


Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser Cys 
    50                  55                  60                  


Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His Ser 
65                  70                  75                  80  


Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile Ser 
                85                  90                  95      


Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala Asp 
            100                 105                 110         


Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala Pro 
        115                 120                 125             


Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala Phe 
    130                 135                 140                 


Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser Phe 
145                 150                 155                 160 


Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 


<210> 2
<211> 307
<212> PRT
<213> Homo sapiens

<400> 2
Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Ser Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Ser Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Ser Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu 
305         


<210> 3
<211> 627
<212> PRT
<213> Homo sapiens

<400> 3
Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210> 4
<211> 123
<212> PRT
<213> Homo sapiens

<400> 4
Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile 
            20                  25                  30          


Trp Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser 
        35                  40                  45              


Pro His Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr 
    50                  55                  60                  


Ser Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn 
65                  70                  75                  80  


Asp Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys 
                85                  90                  95      


Lys Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser 
            100                 105                 110         


Ser Cys Met Ser Ser Ser Arg Pro Ser Ile Ser 
        115                 120             


<210> 5
<211> 205
<212> PRT
<213> Homo sapiens

<400> 5
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205 


<210> 6
<211> 627
<212> PRT
<213> Homo sapiens

<400> 6
Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210> 7
<211> 328
<212> PRT
<213> Homo sapiens

<400> 7
Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe Asn Lys Arg Asp Leu Ile Lys Lys His Ile 
            20                  25                  30          


Trp Pro Asn Val Pro Asp Pro Ser Lys Ser His Ile Ala Gln Trp Ser 
        35                  40                  45              


Pro His Thr Pro Pro Arg His Asn Phe Asn Ser Lys Asp Gln Met Tyr 
    50                  55                  60                  


Ser Asp Gly Asn Phe Thr Asp Val Ser Val Val Glu Ile Glu Ala Asn 
65                  70                  75                  80  


Asp Lys Lys Pro Phe Pro Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys 
                85                  90                  95      


Lys Glu Lys Ile Asn Thr Glu Gly His Ser Ser Gly Ile Gly Gly Ser 
            100                 105                 110         


Ser Cys Met Ser Ser Ser Arg Pro Ser Ile Ser Ala Ser Leu Ser Ser 
        115                 120                 125             


Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe Phe Phe 
    130                 135                 140                 


His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr Phe Thr 
145                 150                 155                 160 


Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala Gly Ala 
                165                 170                 175     


Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly Glu Asp 
            180                 185                 190         


Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu Phe Ser 
        195                 200                 205             


Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly 
    210                 215                 220                 


Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val 
225                 230                 235                 240 


Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val 
                245                 250                 255     


Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu 
            260                 265                 270         


Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe 
        275                 280                 285             


Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala 
    290                 295                 300                 


Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln 
305                 310                 315                 320 


Gly Gln Asp Pro Thr His Leu Val 
                325             


<210> 8
<211> 627
<212> PRT
<213> Homo sapiens

<400> 8
Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu Glu Cys Gly His Ile Ser Val Ser 
            20                  25                  30          


Ala Pro Ile Val His Leu Gly Asp Pro Ile Thr Ala Ser Cys Ile Ile 
        35                  40                  45              


Lys Gln Asn Cys Ser His Leu Asp Pro Glu Pro Gln Ile Leu Trp Arg 
    50                  55                  60                  


Leu Gly Ala Glu Leu Gln Pro Gly Gly Arg Gln Gln Arg Leu Ser Asp 
65                  70                  75                  80  


Gly Thr Gln Glu Ser Ile Ile Thr Leu Pro His Leu Asn His Thr Gln 
                85                  90                  95      


Ala Phe Leu Ser Cys Cys Leu Asn Trp Gly Asn Ser Leu Gln Ile Leu 
            100                 105                 110         


Asp Gln Val Glu Leu Arg Ala Gly Tyr Pro Pro Ala Ile Pro His Asn 
        115                 120                 125             


Leu Ser Cys Leu Met Asn Leu Thr Thr Ser Ser Leu Ile Cys Gln Trp 
    130                 135                 140                 


Glu Pro Gly Pro Glu Thr His Leu Pro Thr Ser Phe Thr Leu Lys Ser 
145                 150                 155                 160 


Phe Lys Ser Arg Gly Asn Cys Gln Thr Gln Gly Asp Ser Ile Leu Asp 
                165                 170                 175     


Cys Val Pro Lys Asp Gly Gln Ser His Cys Cys Ile Pro Arg Lys His 
            180                 185                 190         


Leu Leu Leu Tyr Gln Asn Met Gly Ile Trp Val Gln Ala Glu Asn Ala 
        195                 200                 205             


Leu Gly Thr Ser Met Ser Pro Gln Leu Cys Leu Asp Pro Met Asp Val 
    210                 215                 220                 


Val Lys Leu Glu Pro Pro Met Leu Arg Thr Met Asp Pro Ser Pro Glu 
225                 230                 235                 240 


Ala Ala Pro Pro Gln Ala Gly Cys Leu Gln Leu Cys Trp Glu Pro Trp 
                245                 250                 255     


Gln Pro Gly Leu His Ile Asn Gln Lys Cys Glu Leu Arg His Lys Pro 
            260                 265                 270         


Gln Arg Gly Glu Ala Ser Trp Ala Leu Val Gly Pro Leu Pro Leu Glu 
        275                 280                 285             


Ala Leu Gln Tyr Glu Leu Cys Gly Leu Leu Pro Ala Thr Ala Tyr Thr 
    290                 295                 300                 


Leu Gln Ile Arg Cys Ile Arg Trp Pro Leu Pro Gly His Trp Ser Asp 
305                 310                 315                 320 


Trp Ser Pro Ser Leu Glu Leu Arg Thr Thr Glu Arg Ala Pro Thr Val 
                325                 330                 335     


Arg Leu Asp Thr Trp Trp Arg Gln Arg Gln Leu Asp Pro Arg Thr Val 
            340                 345                 350         


Gln Leu Phe Trp Lys Pro Val Pro Leu Glu Glu Asp Ser Gly Arg Ile 
        355                 360                 365             


Gln Gly Tyr Val Val Ser Trp Arg Pro Ser Gly Gln Ala Gly Ala Ile 
    370                 375                 380                 


Leu Pro Leu Cys Asn Thr Thr Glu Leu Ser Cys Thr Phe His Leu Pro 
385                 390                 395                 400 


Ser Glu Ala Gln Glu Val Ala Leu Val Ala Tyr Asn Ser Ala Gly Thr 
                405                 410                 415     


Ser Arg Pro Thr Pro Val Val Phe Ser Glu Ser Arg Gly Pro Ala Leu 
            420                 425                 430         


Thr Arg Leu His Ala Met Ala Arg Asp Pro His Ser Leu Trp Val Gly 
        435                 440                 445             


Trp Glu Pro Pro Asn Pro Trp Pro Gln Gly Tyr Val Ile Glu Trp Gly 
    450                 455                 460                 


Leu Gly Pro Pro Ser Ala Ser Asn Ser Asn Lys Thr Trp Arg Met Glu 
465                 470                 475                 480 


Gln Asn Gly Arg Ala Thr Gly Phe Leu Leu Lys Glu Asn Ile Arg Pro 
                485                 490                 495     


Phe Gln Leu Tyr Glu Ile Ile Val Thr Pro Leu Tyr Gln Asp Thr Met 
            500                 505                 510         


Gly Pro Ser Gln His Val Tyr Ala Tyr Ser Gln Glu Met Ala Pro Ser 
        515                 520                 525             


His Ala Pro Glu Leu His Leu Lys His Ile Gly Lys Thr Trp Ala Gln 
    530                 535                 540                 


Leu Glu Trp Val Pro Glu Pro Pro Glu Leu Gly Lys Ser Pro Leu Thr 
545                 550                 555                 560 


His Tyr Thr Ile Phe Trp Thr Asn Ala Gln Asn Gln Ser Phe Ser Ala 
                565                 570                 575     


Ile Leu Asn Ala Ser Ser Arg Gly Phe Val Leu His Gly Leu Glu Pro 
            580                 585                 590         


Ala Ser Leu Tyr His Ile His Leu Met Ala Ala Ser Gln Ala Gly Ala 
        595                 600                 605             


Thr Asn Ser Thr Val Leu Thr Leu Met Thr Leu Thr Pro Glu Gly Ser 
    610                 615                 620                 


Glu Leu His 
625         


<210> 9
<211> 107
<212> PRT
<213> Homo sapiens

<400> 9
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys 
            20                  25                  30          


Asn Leu Glu Asp Leu Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp 
        35                  40                  45              


Ser Gly Val Ser Lys Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser 
    50                  55                  60                  


Glu Arg Leu Cys Leu Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu 
65                  70                  75                  80  


Gly Glu Gly Pro Gly Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp 
                85                  90                  95      


Ala Pro Pro Cys Tyr Thr Leu Lys Pro Glu Thr 
            100                 105         


<210> 10

<400> 10
000


<210> 11
<211> 24
<212> PRT
<213> Homo sapiens

<400> 11
Met Ala Arg Leu Gly Asn Cys Ser Leu Thr Trp Ala Ala Leu Ile Ile 
1               5                   10                  15      


Leu Leu Leu Pro Gly Ser Leu Glu 
            20                  


<210> 12
<211> 22
<212> PRT
<213> Homo sapiens

<400> 12
Met Leu Leu Leu Val Thr Ser Leu Leu Leu Cys Glu Leu Pro His Pro 
1               5                   10                  15      


Ala Phe Leu Leu Ile Pro 
            20          


<210> 13
<211> 72
<212> DNA
<213> Homo sapiens

<400> 13
atggcaaggc tgggaaactg cagcctgact tgggctgccc tgatcatcct gctgctcccc       60

ggaagtctgg ag                                                           72


<210> 14
<211> 66
<212> DNA
<213> Mus musculus

<400> 14
atgctgctgc tagtgacctc cctgctgctc tgtgagctgc ctcacccggc gttcctgctg       60

attcct                                                                  66


<210> 15
<211> 603
<212> PRT
<213> Homo sapiens

<400> 15
Glu Cys Gly His Ile Ser Val Ser Ala Pro Ile Val His Leu Gly Asp 
1               5                   10                  15      


Pro Ile Thr Ala Ser Cys Ile Ile Lys Gln Asn Cys Ser His Leu Asp 
            20                  25                  30          


Pro Glu Pro Gln Ile Leu Trp Arg Leu Gly Ala Glu Leu Gln Pro Gly 
        35                  40                  45              


Gly Arg Gln Gln Arg Leu Ser Asp Gly Thr Gln Glu Ser Ile Ile Thr 
    50                  55                  60                  


Leu Pro His Leu Asn His Thr Gln Ala Phe Leu Ser Cys Cys Leu Asn 
65                  70                  75                  80  


Trp Gly Asn Ser Leu Gln Ile Leu Asp Gln Val Glu Leu Arg Ala Gly 
                85                  90                  95      


Tyr Pro Pro Ala Ile Pro His Asn Leu Ser Cys Leu Met Asn Leu Thr 
            100                 105                 110         


Thr Ser Ser Leu Ile Cys Gln Trp Glu Pro Gly Pro Glu Thr His Leu 
        115                 120                 125             


Pro Thr Ser Phe Thr Leu Lys Ser Phe Lys Ser Arg Gly Asn Cys Gln 
    130                 135                 140                 


Thr Gln Gly Asp Ser Ile Leu Asp Cys Val Pro Lys Asp Gly Gln Ser 
145                 150                 155                 160 


His Cys Cys Ile Pro Arg Lys His Leu Leu Leu Tyr Gln Asn Met Gly 
                165                 170                 175     


Ile Trp Val Gln Ala Glu Asn Ala Leu Gly Thr Ser Met Ser Pro Gln 
            180                 185                 190         


Leu Cys Leu Asp Pro Met Asp Val Val Lys Leu Glu Pro Pro Met Leu 
        195                 200                 205             


Arg Thr Met Asp Pro Ser Pro Glu Ala Ala Pro Pro Gln Ala Gly Cys 
    210                 215                 220                 


Leu Gln Leu Cys Trp Glu Pro Trp Gln Pro Gly Leu His Ile Asn Gln 
225                 230                 235                 240 


Lys Cys Glu Leu Arg His Lys Pro Gln Arg Gly Glu Ala Ser Trp Ala 
                245                 250                 255     


Leu Val Gly Pro Leu Pro Leu Glu Ala Leu Gln Tyr Glu Leu Cys Gly 
            260                 265                 270         


Leu Leu Pro Ala Thr Ala Tyr Thr Leu Gln Ile Arg Cys Ile Arg Trp 
        275                 280                 285             


Pro Leu Pro Gly His Trp Ser Asp Trp Ser Pro Ser Leu Glu Leu Arg 
    290                 295                 300                 


Thr Thr Glu Arg Ala Pro Thr Val Arg Leu Asp Thr Trp Trp Arg Gln 
305                 310                 315                 320 


Arg Gln Leu Asp Pro Arg Thr Val Gln Leu Phe Trp Lys Pro Val Pro 
                325                 330                 335     


Leu Glu Glu Asp Ser Gly Arg Ile Gln Gly Tyr Val Val Ser Trp Arg 
            340                 345                 350         


Pro Ser Gly Gln Ala Gly Ala Ile Leu Pro Leu Cys Asn Thr Thr Glu 
        355                 360                 365             


Leu Ser Cys Thr Phe His Leu Pro Ser Glu Ala Gln Glu Val Ala Leu 
    370                 375                 380                 


Val Ala Tyr Asn Ser Ala Gly Thr Ser Arg Pro Thr Pro Val Val Phe 
385                 390                 395                 400 


Ser Glu Ser Arg Gly Pro Ala Leu Thr Arg Leu His Ala Met Ala Arg 
                405                 410                 415     


Asp Pro His Ser Leu Trp Val Gly Trp Glu Pro Pro Asn Pro Trp Pro 
            420                 425                 430         


Gln Gly Tyr Val Ile Glu Trp Gly Leu Gly Pro Pro Ser Ala Ser Asn 
        435                 440                 445             


Ser Asn Lys Thr Trp Arg Met Glu Gln Asn Gly Arg Ala Thr Gly Phe 
    450                 455                 460                 


Leu Leu Lys Glu Asn Ile Arg Pro Phe Gln Leu Tyr Glu Ile Ile Val 
465                 470                 475                 480 


Thr Pro Leu Tyr Gln Asp Thr Met Gly Pro Ser Gln His Val Tyr Ala 
                485                 490                 495     


Tyr Ser Gln Glu Met Ala Pro Ser His Ala Pro Glu Leu His Leu Lys 
            500                 505                 510         


His Ile Gly Lys Thr Trp Ala Gln Leu Glu Trp Val Pro Glu Pro Pro 
        515                 520                 525             


Glu Leu Gly Lys Ser Pro Leu Thr His Tyr Thr Ile Phe Trp Thr Asn 
    530                 535                 540                 


Ala Gln Asn Gln Ser Phe Ser Ala Ile Leu Asn Ala Ser Ser Arg Gly 
545                 550                 555                 560 


Phe Val Leu His Gly Leu Glu Pro Ala Ser Leu Tyr His Ile His Leu 
                565                 570                 575     


Met Ala Ala Ser Gln Ala Gly Ala Thr Asn Ser Thr Val Leu Thr Leu 
            580                 585                 590         


Met Thr Leu Thr Pro Glu Gly Ser Glu Leu His 
        595                 600             


<210> 16
<211> 1809
<212> DNA
<213> Homo sapiens

<400> 16
gagtgcgggc acatcagtgt ctcagccccc atcgtccacc tgggggatcc catcacagcc       60

tcctgcatca tcaagcagaa ctgcagccat ctggacccgg agccacagat tctgtggaga      120

ctgggagcag agcttcagcc cgggggcagg cagcagcgtc tgtctgatgg gacccaggaa      180

tctatcatca ccctgcccca cctcaaccac actcaggcct ttctctcctg ctgcctgaac      240

tggggcaaca gcctgcagat cctggaccag gttgagctgc gcgcaggcta ccctccagcc      300

ataccccaca acctctcctg cctcatgaac ctcacaacca gcagcctcat ctgccagtgg      360

gagccaggac ctgagaccca cctacccacc agcttcactc tgaagagttt caagagccgg      420

ggcaactgtc agacccaagg ggactccatc ctggactgcg tgcccaagga cgggcagagc      480

cactgctgca tcccacgcaa acacctgctg ttgtaccaga atatgggcat ctgggtgcag      540

gcagagaatg cgctggggac cagcatgtcc ccacaactgt gtcttgatcc catggatgtt      600

gtgaaactgg agccccccat gctgcggacc atggacccca gccctgaagc ggcccctccc      660

caggcaggct gcctacagct gtgctgggag ccatggcagc caggcctgca cataaatcag      720

aagtgtgagc tgcgccacaa gccgcagcgt ggagaagcca gctgggcact ggtgggcccc      780

ctccccttgg aggcccttca gtatgagctc tgcgggctcc tcccagccac ggcctacacc      840

ctgcagatac gctgcatccg ctggcccctg cctggccact ggagcgactg gagccccagc      900

ctggagctga gaactaccga acgggccccc actgtcagac tggacacatg gtggcggcag      960

aggcagctgg accccaggac agtgcagctg ttctggaagc cagtgcccct ggaggaagac     1020

agcggacgga tccaaggtta tgtggtttct tggagaccct caggccaggc tggggccatc     1080

ctgcccctct gcaacaccac agagctcagc tgcaccttcc acctgccttc agaagcccag     1140

gaggtggccc ttgtggccta taactcagcc gggacctctc gtcccactcc ggtggtcttc     1200

tcagaaagca gaggcccagc tctgaccaga ctccatgcca tggcccgaga ccctcacagc     1260

ctctgggtag gctgggagcc ccccaatcca tggcctcagg gctatgtgat tgagtggggc     1320

ctgggccccc ccagcgcgag caatagcaac aagacctgga ggatggaaca gaatgggaga     1380

gccacggggt ttctgctgaa ggagaacatc aggccctttc agctctatga gatcatcgtg     1440

actcccttgt accaggacac catgggaccc tcccagcatg tctatgccta ctctcaagaa     1500

atggctccct cccatgcccc agagctgcat ctaaagcaca ttggcaagac ctgggcacag     1560

ctggagtggg tgcctgagcc ccctgagctg gggaagagcc cccttaccca ctacaccatc     1620

ttctggacca acgctcagaa ccagtccttc tccgccatcc tgaatgcctc ctcccgtggc     1680

tttgtcctcc atggcctgga gcccgccagt ctgtatcaca tccacctcat ggctgccagc     1740

caggctgggg ccaccaacag tacagtcctc accctgatga ccttgacccc agaggggtcg     1800

gagctacac                                                             1809


<210> 17
<211> 1809
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 17
gagtgcgggc acatcagtgt ctcagccccc atcgtccacc tgggggatcc catcacagcc       60

tcctgcatca tcaagcagaa ctgcagccat ctggacccgg agccacagat tctgtggaga      120

ctgggagcag agcttcagcc cgggggcagg cagcagcgtc tgtctgatgg gacccaggaa      180

tctatcatca ccctgcccca cctcaaccac actcaggcct ttctctcctg ctgcctgaac      240

tggggcaaca gcctgcagat cctggaccag gttgagctgc gcgcaggcta ccctccagcc      300

ataccccaca acctctcctg cctcatgaac ctcacaacca gcagcctcat ctgccagtgg      360

gagccaggac ctgagaccca cctacccacc agcttcactc tgaagagttt caagagccgg      420

ggcaactgtc agacccaagg ggactccatc ctggactgcg tgcccaagga cgggcagagc      480

cactgctgca tcccacgcaa acacctgctg ttgtaccaga atatgggcat ctgggtgcag      540

gcagagaatg cgctggggac cagcatgtcc ccacaactgt gtcttgatcc catggatgtt      600

gtgaaactgg agccccccat gctgcggacc atggacccca gccctgaagc ggcccctccc      660

caggcaggct gcctacagct gtgctgggag ccatggcagc caggcctgca cataaatcag      720

aagtgtgagc tgcgccacaa gccgcagcgt ggagaagcca gctgggcact ggtgggcccc      780

ctccccttgg aggcccttca gtatgagctc tgcgggctcc tcccagccac ggcctacacc      840

ctgcagatac gctgcatccg ctggcccctg cctggccact ggagcgactg gagccccagc      900

ctggagctga gaactaccga acgggccccc actgtcagac tggacacatg gtggcggcag      960

aggcagctgg accccaggac agtgcagctg ttctggaagc cagtgcccct ggaggaagac     1020

agcggacgca tccaaggtta tgtggtttct tggagaccct caggccaggc tggggccatc     1080

ctgcccctct gcaacaccac agagctcagc tgcaccttcc acctgccttc agaagcccag     1140

gaggtggccc ttgtggccta taactcagcc gggacctctc gccccacccc ggtggtcttc     1200

tcagaaagca gaggcccagc tctgaccaga ctccatgcca tggcccgaga ccctcacagc     1260

ctctgggtag gctgggagcc ccccaatcca tggcctcagg gctatgtgat tgagtggggc     1320

ctgggccccc ccagcgcgag caatagcaac aagacctgga ggatggaaca gaatgggaga     1380

gccacggggt ttctgctgaa ggagaacatc aggccctttc agctctatga gatcatcgtg     1440

actcccttgt accaggacac catgggaccc tcccagcatg tctatgccta ctctcaagaa     1500

atggctccct cccatgcccc agagctgcat ctaaagcaca ttggcaagac ctgggcacag     1560

ctggagtggg tgcctgagcc ccctgagctg gggaagagcc cccttaccca ctacaccatc     1620

ttctggacca acgctcagaa ccagtccttc tccgccatcc tgaatgcatc ctcccgtggc     1680

tttgtcctcc atggcctgga gcccgccagt ctgtatcaca tccacctcat ggctgccagc     1740

caggctgggg ccaccaacag tacagtcctc accctgatga ccttgacccc agaggggtcg     1800

gagctacac                                                             1809


<210> 18
<211> 23
<212> PRT
<213> Homo sapiens

<400> 18
Ile Ile Leu Gly Leu Phe Gly Leu Leu Leu Leu Leu Thr Cys Leu Cys 
1               5                   10                  15      


Gly Thr Ala Trp Leu Cys Cys 
            20              


<210> 19
<211> 22
<212> PRT
<213> Homo sapiens

<400> 19
Ala Ile Val Val Pro Val Cys Leu Ala Phe Leu Leu Thr Thr Leu Leu 
1               5                   10                  15      


Gly Val Leu Phe Cys Phe 
            20          


<210> 20
<211> 25
<212> PRT
<213> Homo sapiens

<400> 20
Ile Pro Trp Leu Gly His Leu Leu Val Gly Leu Ser Gly Ala Phe Gly 
1               5                   10                  15      


Phe Ile Ile Leu Val Tyr Leu Leu Ile 
            20                  25  


<210> 21
<211> 21
<212> PRT
<213> Homo sapiens

<400> 21
Val Val Ile Ser Val Gly Ser Met Gly Leu Ile Ile Ser Leu Leu Cys 
1               5                   10                  15      


Val Tyr Phe Trp Leu 
            20      


<210> 22
<211> 69
<212> DNA
<213> Homo sapiens

<400> 22
atcatcctgg gcctgttcgg cctcctgctg ttgctcacct gcctctgtgg aactgcctgg       60

ctctgttgc                                                               69


<210> 23
<211> 66
<212> DNA
<213> Homo sapiens

<400> 23
gccatagtcg tgcctgtttg cttagcattc ctattgacaa ctcttctggg agtgctgttc       60

tgcttt                                                                  66


<210> 24
<211> 75
<212> DNA
<213> Homo sapiens

<400> 24
attccgtggc tcggccacct cctcgtgggt ctcagcgggg cttttggctt catcatctta       60

gtgtacttgc tgatc                                                        75


<210> 25
<211> 63
<212> DNA
<213> Homo sapiens

<400> 25
gtggttatct ctgttggctc catgggattg attatcagcc ttctctgtgt gtatttctgg       60

ctg                                                                     63


<210> 26
<211> 286
<212> PRT
<213> Homo sapiens

<400> 26
Asn Cys Arg Asn Thr Gly Pro Trp Leu Lys Lys Val Leu Lys Cys Asn 
1               5                   10                  15      


Thr Pro Asp Pro Ser Lys Phe Phe Ser Gln Leu Ser Ser Glu His Gly 
            20                  25                  30          


Gly Asp Val Gln Lys Trp Leu Ser Ser Pro Phe Pro Ser Ser Ser Phe 
        35                  40                  45              


Ser Pro Gly Gly Leu Ala Pro Glu Ile Ser Pro Leu Glu Val Leu Glu 
    50                  55                  60                  


Arg Asp Lys Val Thr Gln Leu Leu Leu Gln Gln Asp Lys Val Pro Glu 
65                  70                  75                  80  


Pro Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn 
                85                  90                  95      


Gln Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala 
            100                 105                 110         


Cys Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp 
        115                 120                 125             


Glu Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln 
    130                 135                 140                 


Pro Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp 
145                 150                 155                 160 


Asp Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro 
                165                 170                 175     


Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro 
            180                 185                 190         


Ser Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly 
        195                 200                 205             


Pro Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro 
    210                 215                 220                 


Glu Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro 
225                 230                 235                 240 


Arg Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu 
                245                 250                 255     


Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu 
            260                 265                 270         


Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        275                 280                 285     


<210> 27
<211> 86
<212> PRT
<213> Homo sapiens

<400> 27
Glu Arg Thr Met Pro Arg Ile Pro Thr Leu Lys Asn Leu Glu Asp Leu 
1               5                   10                  15      


Val Thr Glu Tyr His Gly Asn Phe Ser Ala Trp Ser Gly Val Ser Lys 
            20                  25                  30          


Gly Leu Ala Glu Ser Leu Gln Pro Asp Tyr Ser Glu Arg Leu Cys Leu 
        35                  40                  45              


Val Ser Glu Ile Pro Pro Lys Gly Gly Ala Leu Gly Glu Gly Pro Gly 
    50                  55                  60                  


Ala Ser Pro Cys Asn Gln His Ser Pro Tyr Trp Ala Pro Pro Cys Tyr 
65                  70                  75                  80  


Thr Leu Lys Pro Glu Thr 
                85      


<210> 28
<211> 101
<212> PRT
<213> Homo sapiens

<400> 28
Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser 
            100     


<210> 29
<211> 205
<212> PRT
<213> Homo sapiens

<400> 29
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205 


<210> 30
<211> 62
<212> PRT
<213> Homo sapiens

<400> 30
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210> 31
<211> 202
<212> PRT
<213> Homo sapiens

<400> 31
Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala 
        35                  40                  45              


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
    50                  55                  60                  


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
65                  70                  75                  80  


Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro 
                85                  90                  95      


Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu 
            100                 105                 110         


Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro 
        115                 120                 125             


Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu 
    130                 135                 140                 


Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val 
145                 150                 155                 160 


Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu 
                165                 170                 175     


Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200         


<210> 32
<211> 67
<212> PRT
<213> Homo sapiens

<400> 32
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr 
65          


<210> 33
<211> 72
<212> PRT
<213> Homo sapiens

<400> 33
Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser His Glu Ala Pro Leu Ala Asp Ser Leu Glu Glu Leu 
            20                  25                  30          


Glu Pro Gln His Ile Ser Leu Ser Val Phe Pro Ser Ser Ser Leu His 
        35                  40                  45              


Pro Leu Thr Phe Ser Cys Gly Asp Lys Leu Thr Leu Asp Gln Leu Lys 
    50                  55                  60                  


Met Arg Cys Asp Ser Leu Met Leu 
65                  70          


<210> 34
<211> 67
<212> PRT
<213> Homo sapiens

<400> 34
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr 
65          


<210> 35
<211> 30
<212> PRT
<213> Homo sapiens

<400> 35
Ser Pro Gly Asp Glu Gly Pro Pro Arg Ser Tyr Leu Arg Gln Trp Val 
1               5                   10                  15      


Val Ile Pro Pro Pro Leu Ser Ser Pro Gly Pro Gln Ala Ser 
            20                  25                  30  


<210> 36
<211> 63
<212> PRT
<213> Homo sapiens

<400> 36
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn 
    50                  55                  60              


<210> 37
<211> 183
<212> PRT
<213> Homo sapiens

<400> 37
Gln Asn Ser Gly Gly Ser Ala Tyr Ser Glu Glu Arg Asp Arg Pro Tyr 
1               5                   10                  15      


Gly Leu Val Ser Ile Asp Thr Val Thr Val Leu Asp Ala Glu Gly Pro 
            20                  25                  30          


Cys Thr Trp Pro Cys Ser Cys Glu Asp Asp Gly Tyr Pro Ala Leu Asp 
        35                  40                  45              


Leu Asp Ala Gly Leu Glu Pro Ser Pro Gly Leu Glu Asp Pro Leu Leu 
    50                  55                  60                  


Asp Ala Gly Thr Thr Val Leu Ser Cys Gly Cys Val Ser Ala Gly Ser 
65                  70                  75                  80  


Pro Gly Leu Gly Gly Pro Leu Gly Ser Leu Leu Asp Arg Leu Lys Pro 
                85                  90                  95      


Pro Leu Ala Asp Gly Glu Asp Trp Ala Gly Gly Leu Pro Trp Gly Gly 
            100                 105                 110         


Arg Ser Pro Gly Gly Val Ser Glu Ser Glu Ala Gly Ser Pro Leu Ala 
        115                 120                 125             


Gly Leu Asp Met Asp Thr Phe Asp Ser Gly Phe Val Gly Ser Asp Cys 
    130                 135                 140                 


Ser Ser Pro Val Glu Cys Asp Phe Thr Ser Pro Gly Asp Glu Gly Pro 
145                 150                 155                 160 


Pro Arg Ser Tyr Leu Arg Gln Trp Val Val Ile Pro Pro Pro Leu Ser 
                165                 170                 175     


Ser Pro Gly Pro Gln Ala Ser 
            180             


<210> 38
<211> 93
<212> PRT
<213> Homo sapiens

<400> 38
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210> 39
<211> 202
<212> PRT
<213> Homo sapiens

<400> 39
Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu Gly Val Ala 
        35                  40                  45              


Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro Leu Ser Gly 
    50                  55                  60                  


Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp Leu Leu Leu 
65                  70                  75                  80  


Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro 
                85                  90                  95      


Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser Leu Gln Glu 
            100                 105                 110         


Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro 
        115                 120                 125             


Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu Leu Val Leu 
    130                 135                 140                 


Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg Glu Gly Val 
145                 150                 155                 160 


Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu 
                165                 170                 175     


Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu 
            180                 185                 190         


Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200         


<210> 40
<211> 62
<212> PRT
<213> Homo sapiens

<400> 40
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210> 41
<211> 43
<212> PRT
<213> Homo sapiens

<400> 41
Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
        35                  40              


<210> 42
<211> 20
<212> PRT
<213> Homo sapiens

<400> 42
Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser 
            20  


<210> 43
<211> 116
<212> PRT
<213> Homo sapiens

<400> 43
Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
1               5                   10                  15      


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
            20                  25                  30          


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
        35                  40                  45              


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
    50                  55                  60                  


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
65                  70                  75                  80  


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210> 44
<211> 93
<212> PRT
<213> Homo sapiens

<400> 44
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210> 45
<211> 43
<212> PRT
<213> Homo sapiens

<400> 45
Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln Gly Tyr Phe 
1               5                   10                  15      


Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys Gln Val Tyr 
            20                  25                  30          


Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro 
        35                  40              


<210> 46
<211> 20
<212> PRT
<213> Homo sapiens

<400> 46
Ala Gly Asp Leu Pro Thr His Asp Gly Tyr Leu Pro Ser Asn Ile Asp 
1               5                   10                  15      


Asp Leu Pro Ser 
            20  


<210> 47
<211> 116
<212> PRT
<213> Homo sapiens

<400> 47
Gly Gly Pro Ser Pro Pro Ser Thr Ala Pro Gly Gly Ser Gly Ala Gly 
1               5                   10                  15      


Glu Glu Arg Met Pro Pro Ser Leu Gln Glu Arg Val Pro Arg Asp Trp 
            20                  25                  30          


Asp Pro Gln Pro Leu Gly Pro Pro Thr Pro Gly Val Pro Asp Leu Val 
        35                  40                  45              


Asp Phe Gln Pro Pro Pro Glu Leu Val Leu Arg Glu Ala Gly Glu Glu 
    50                  55                  60                  


Val Pro Asp Ala Gly Pro Arg Glu Gly Val Ser Phe Pro Trp Ser Arg 
65                  70                  75                  80  


Pro Pro Gly Gln Gly Glu Phe Arg Ala Leu Asn Ala Arg Leu Pro Leu 
                85                  90                  95      


Asn Thr Asp Ala Tyr Leu Ser Leu Gln Glu Leu Gln Gly Gln Asp Pro 
            100                 105                 110         


Thr His Leu Val 
        115     


<210> 48
<211> 138
<212> PRT
<213> Homo sapiens

<400> 48
Asn Lys Arg Asp Leu Ile Lys Lys His Ile Trp Pro Asn Val Pro Asp 
1               5                   10                  15      


Pro Ser Lys Ser His Ile Ala Gln Trp Ser Pro His Thr Pro Pro Arg 
            20                  25                  30          


His Asn Phe Asn Ser Lys Asp Gln Met Tyr Ser Asp Gly Asn Phe Thr 
        35                  40                  45              


Asp Val Ser Val Val Glu Ile Glu Ala Asn Asp Lys Lys Pro Phe Pro 
    50                  55                  60                  


Glu Asp Leu Lys Ser Leu Asp Leu Phe Lys Lys Glu Lys Ile Asn Thr 
65                  70                  75                  80  


Glu Gly His Ser Ser Gly Ile Gly Gly Ser Ser Cys Met Ser Ser Ser 
                85                  90                  95      


Arg Pro Ser Ile Ser Ser Ser Asp Glu Asn Glu Ser Ser Gln Asn Thr 
            100                 105                 110         


Ser Ser Thr Val Gln Tyr Ser Thr Val Val His Ser Gly Tyr Arg His 
        115                 120                 125             


Gln Val Pro Ser Val Gln Val Phe Ser Arg 
    130                 135             


<210> 49
<211> 205
<212> PRT
<213> Homo sapiens

<400> 49
Ala Ser Leu Ser Ser Asn His Ser Leu Thr Ser Cys Phe Thr Asn Gln 
1               5                   10                  15      


Gly Tyr Phe Phe Phe His Leu Pro Asp Ala Leu Glu Ile Glu Ala Cys 
            20                  25                  30          


Gln Val Tyr Phe Thr Tyr Asp Pro Tyr Ser Glu Glu Asp Pro Asp Glu 
        35                  40                  45              


Gly Val Ala Gly Ala Pro Thr Gly Ser Ser Pro Gln Pro Leu Gln Pro 
    50                  55                  60                  


Leu Ser Gly Glu Asp Asp Ala Tyr Cys Thr Phe Pro Ser Arg Asp Asp 
65                  70                  75                  80  


Leu Leu Leu Phe Ser Pro Ser Leu Leu Gly Gly Pro Ser Pro Pro Ser 
                85                  90                  95      


Thr Ala Pro Gly Gly Ser Gly Ala Gly Glu Glu Arg Met Pro Pro Ser 
            100                 105                 110         


Leu Gln Glu Arg Val Pro Arg Asp Trp Asp Pro Gln Pro Leu Gly Pro 
        115                 120                 125             


Pro Thr Pro Gly Val Pro Asp Leu Val Asp Phe Gln Pro Pro Pro Glu 
    130                 135                 140                 


Leu Val Leu Arg Glu Ala Gly Glu Glu Val Pro Asp Ala Gly Pro Arg 
145                 150                 155                 160 


Glu Gly Val Ser Phe Pro Trp Ser Arg Pro Pro Gly Gln Gly Glu Phe 
                165                 170                 175     


Arg Ala Leu Asn Ala Arg Leu Pro Leu Asn Thr Asp Ala Tyr Leu Ser 
            180                 185                 190         


Leu Gln Glu Leu Gln Gly Gln Asp Pro Thr His Leu Val 
        195                 200                 205 


<210> 50
<211> 62
<212> PRT
<213> Homo sapiens

<400> 50
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His 
    50                  55                  60          


<210> 51
<211> 67
<212> PRT
<213> Homo sapiens

<400> 51
Ser Gly Lys Asn Gly Pro His Val Tyr Gln Asp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Gly Thr Thr Asn Ser Thr Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly 
            20                  25                  30          


Ile Leu Thr Leu Asn Pro Val Ala Gln Gly Gln Pro Ile Leu Thr Ser 
        35                  40                  45              


Leu Gly Ser Asn Gln Glu Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr 
    50                  55                  60                  


Gln Asn Gln 
65          


<210> 52
<211> 93
<212> PRT
<213> Homo sapiens

<400> 52
Ser Pro Asn Arg Lys Asn Pro Leu Trp Pro Ser Val Pro Asp Pro Ala 
1               5                   10                  15      


His Ser Ser Leu Gly Ser Trp Val Pro Thr Ile Met Glu Glu Asp Ala 
            20                  25                  30          


Phe Gln Leu Pro Gly Leu Gly Thr Pro Pro Ile Thr Lys Leu Thr Val 
        35                  40                  45              


Leu Glu Glu Asp Glu Lys Lys Pro Val Pro Trp Glu Ser His Asn Ser 
    50                  55                  60                  


Ser Glu Thr Cys Gly Leu Pro Thr Leu Val Gln Thr Tyr Val Leu Gln 
65                  70                  75                  80  


Gly Asp Pro Arg Ala Val Ser Thr Gln Pro Gln Ser Gln 
                85                  90              


<210> 53
<211> 77
<212> PRT
<213> Homo sapiens

<400> 53
Ser Ser Ser Arg Ser Leu Asp Cys Arg Glu Ser Gly Lys Asn Gly Pro 
1               5                   10                  15      


His Val Tyr Gln Asp Leu Leu Leu Ser Leu Gly Thr Thr Asn Ser Thr 
            20                  25                  30          


Leu Pro Pro Pro Phe Ser Leu Gln Ser Gly Ile Leu Thr Leu Asn Pro 
        35                  40                  45              


Val Ala Gln Gly Gln Pro Ile Leu Thr Ser Leu Gly Ser Asn Gln Glu 
    50                  55                  60                  


Glu Ala Tyr Val Thr Met Ser Ser Phe Tyr Gln Asn Gln 
65                  70                  75          


<210> 54
<211> 861
<212> DNA
<213> Homo sapiens

<400> 54
aactgcagga acaccgggcc atggctgaag aaggtcctga agtgtaacac cccagacccc       60

tcgaagttct tttcccagct gagctcagag catggaggag acgtccagaa gtggctctct      120

tcgcccttcc cctcatcgtc cttcagccct ggcggcctgg cacctgagat ctcgccacta      180

gaagtgctgg agagggacaa ggtgacgcag ctgctcctgc agcaggacaa ggtgcctgag      240

cccgcatcct taagcagcaa ccactcgctg accagctgct tcaccaacca gggttacttc      300

ttcttccacc tcccggatgc cttggagata gaggcctgcc aggtgtactt tacttacgac      360

ccctactcag aggaagaccc tgatgagggt gtggccgggg cacccacagg gtcttccccc      420

caacccctgc agcctctgtc aggggaggac gacgcctact gcaccttccc ctccagggat      480

gacctgctgc tcttctcccc cagtctcctc ggtggcccca gccccccaag cactgcccct      540

gggggcagtg gggccggtga agagaggatg cccccttctt tgcaagaaag agtccccaga      600

gactgggacc cccagcccct ggggcctccc accccaggag tcccagacct ggtggatttt      660

cagccacccc ctgagctggt gctgcgagag gctggggagg aggtccctga cgctggcccc      720

agggagggag tcagtttccc ctggtccagg cctcctgggc agggggagtt cagggccctt      780

aatgctcgcc tgcccctgaa cactgatgcc tacttgtccc tccaagaact ccagggtcag      840

gacccaactc acttggtgta g                                                861


<210> 55
<211> 261
<212> DNA
<213> Homo sapiens

<400> 55
gaacggacga tgccccgaat tcccaccctg aagaacctag aggatcttgt tactgaatac       60

cacgggaact tttcggcctg gagtggtgtg tctaagggac tggctgagag tctgcagcca      120

gactacagtg aacgactctg cctcgtcagt gagattcccc caaaaggagg ggcccttggg      180

gaggggcctg gggcctcccc atgcaaccag catagcccct actgggcccc cccatgttac      240

accctaaagc ctgaaacctg a                                                261


<210> 56
<211> 303
<212> DNA
<213> Homo sapiens

<400> 56
aataagcgag acctaattaa aaaacacatc tggcctaatg ttccagatcc ttcaaagagt       60

catattgccc agtggtcacc tcacactcct ccaaggcaca attttaattc aaaagatcaa      120

atgtattcag atggcaattt cactgatgta agtgttgtgg aaatagaagc aaatgacaaa      180

aagccttttc cagaagatct gaaatcattg gacctgttca aaaaggaaaa aattaatact      240

gaaggacaca gcagtggtat tggggggtct tcatgtatgt catcttctag gccaagcatt      300

tct                                                                    303


<210> 57
<211> 618
<212> DNA
<213> Homo sapiens

<400> 57
gcatccttaa gcagcaacca ctcgctgacc agctgcttca ccaaccaggg ttacttcttc       60

ttccacctcc cggatgcctt ggagatagag gcctgccagg tgtactttac ttacgacccc      120

tactcagagg aagaccctga tgagggtgtg gccggggcac ccacagggtc ttccccccaa      180

cccctgcagc ctctgtcagg ggaggacgac gcctactgca ccttcccctc cagggatgac      240

ctgctgctct tctcccccag tctcctcggt ggccccagcc ccccaagcac tgcccctggg      300

ggcagtgggg ccggtgaaga gaggatgccc ccttctttgc aagaaagagt ccccagagac      360

tgggaccccc agcccctggg gcctcccacc ccaggagtcc cagacctggt ggattttcag      420

ccaccccctg agctggtgct gcgagaggct ggggaggagg tccctgacgc tggccccagg      480

gagggagtca gtttcccctg gtccaggcct cctgggcagg gggagttcag ggcccttaat      540

gctcgcctgc ccctgaacac tgatgcctac ttgtccctcc aagaactcca gggtcaggac      600

ccaactcact tggtgtag                                                    618


<210> 58
<211> 186
<212> DNA
<213> Homo sapiens

<400> 58
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210> 59
<211> 609
<212> DNA
<213> Homo sapiens

<400> 59
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccctg atgagggtgt ggccggggca cccacagggt cttcccccca acccctgcag      180

cctctgtcag gggaggacga cgcctactgc accttcccct ccagggatga cctgctgctc      240

ttctccccca gtctcctcgg tggccccagc cccccaagca ctgcccctgg gggcagtggg      300

gccggtgaag agaggatgcc cccttctttg caagaaagag tccccagaga ctgggacccc      360

cagcccctgg ggcctcccac cccaggagtc ccagacctgg tggattttca gccaccccct      420

gagctggtgc tgcgagaggc tggggaggag gtccctgacg ctggccccag ggagggagtc      480

agtttcccct ggtccaggcc tcctgggcag ggggagttca gggcccttaa tgctcgcctg      540

cccctgaaca ctgatgccta cttgtccctc caagaactcc agggtcagga cccaactcac      600

ttggtgtag                                                              609


<210> 60
<211> 201
<212> DNA
<213> Homo sapiens

<400> 60
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac c                                                201


<210> 61
<211> 219
<212> DNA
<213> Homo sapiens

<400> 61
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60

catgaggcac ctctcgctga ctctctggaa gaactggagc ctcagcacat ctccctttct      120

gttttcccct caagttctct tcacccactc accttctcct gtggtgataa gctgactctg      180

gatcagttaa agatgaggtg tgactccctc atgctctga                             219


<210> 62
<211> 201
<212> DNA
<213> Homo sapiens

<400> 62
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac c                                                201


<210> 63
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 63
agccctgggg acgaaggacc cccccggagc tacctccgcc agtgggtggt cattcctccg       60

ccactttcga gccctggacc ccaggccagc taa                                    93


<210> 64
<211> 189
<212> DNA
<213> Homo sapiens

<400> 64
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataac                                                              189


<210> 65
<211> 549
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 65
cagaactcgg ggggctcagc ttacagtgag gagagggatc ggccatacgg cctggtgtcc       60

attgacacag tgactgtgct agatgcagag gggccatgca cctggccctg cagctgtgag      120

gatgacggct acccagccct ggacctggat gctggcctgg agcccagccc aggcctagag      180

gacccactct tggatgcagg gaccacagtc ctgtcctgtg gctgtgtctc agctggcagc      240

cctgggctag gagggcccct gggaagcctc ctggacagac taaagccacc ccttgcagat      300

ggggaggact gggctggggg actgccctgg ggtggccggt cacctggagg ggtctcagag      360

agtgaggcgg gctcacccct ggccggcctg gatatggaca cgtttgacag tggctttgtg      420

ggctctgact gcagcagccc tgtggagtgt gacttcacca gccctgggga cgaaggaccc      480

ccccggagct acctccgcca gtgggtggtc attcctccgc cactttcgag ccctggaccc      540

caggccagc                                                              549


<210> 66
<211> 279
<212> DNA
<213> Homo sapiens

<400> 66
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210> 67
<211> 609
<212> DNA
<213> Homo sapiens

<400> 67
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccctg atgagggtgt ggccggggca cccacagggt cttcccccca acccctgcag      180

cctctgtcag gggaggacga cgcctactgc accttcccct ccagggatga cctgctgctc      240

ttctccccca gtctcctcgg tggccccagc cccccaagca ctgcccctgg gggcagtggg      300

gccggtgaag agaggatgcc cccttctttg caagaaagag tccccagaga ctgggacccc      360

cagcccctgg ggcctcccac cccaggagtc ccagacctgg tggattttca gccaccccct      420

gagctggtgc tgcgagaggc tggggaggag gtccctgacg ctggccccag ggagggagtc      480

agtttcccct ggtccaggcc tcctgggcag ggggagttca gggcccttaa tgctcgcctg      540

cccctgaaca ctgatgccta cttgtccctc caagaactcc agggtcagga cccaactcac      600

ttggtgtag                                                              609


<210> 68
<211> 186
<212> DNA
<213> Homo sapiens

<400> 68
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210> 69
<211> 129
<212> DNA
<213> Homo sapiens

<400> 69
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccct                                                              129


<210> 70
<211> 60
<212> DNA
<213> Homo sapiens

<400> 70
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60


<210> 71
<211> 351
<212> DNA
<213> Homo sapiens

<400> 71
ggtggcccca gccccccaag cactgcccct gggggcagtg gggccggtga agagaggatg       60

cccccttctt tgcaagaaag agtccccaga gactgggacc cccagcccct ggggcctccc      120

accccaggag tcccagacct ggtggatttt cagccacccc ctgagctggt gctgcgagag      180

gctggggagg aggtccctga cgctggcccc agggagggag tcagtttccc ctggtccagg      240

cctcctgggc agggggagtt cagggccctt aatgctcgcc tgcccctgaa cactgatgcc      300

tacttgtccc tccaagaact ccagggtcag gacccaactc acttggtgta g               351


<210> 72
<211> 279
<212> DNA
<213> Homo sapiens

<400> 72
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210> 73
<211> 129
<212> DNA
<213> Homo sapiens

<400> 73
agcagcaacc actcgctgac cagctgcttc accaaccagg gttacttctt cttccacctc       60

ccggatgcct tggagataga ggcctgccag gtgtacttta cttacgaccc ctactcagag      120

gaagaccct                                                              129


<210> 74
<211> 60
<212> DNA
<213> Homo sapiens

<400> 74
gcaggtgacc ttcccaccca tgatggctac ttaccctcca acatagatga cctcccctca       60


<210> 75
<211> 351
<212> DNA
<213> Homo sapiens

<400> 75
ggtggcccca gccccccaag cactgcccct gggggcagtg gggccggtga agagaggatg       60

cccccttctt tgcaagaaag agtccccaga gactgggacc cccagcccct ggggcctccc      120

accccaggag tcccagacct ggtggatttt cagccacccc ctgagctggt gctgcgagag      180

gctggggagg aggtccctga cgctggcccc agggagggag tcagtttccc ctggtccagg      240

cctcctgggc agggggagtt cagggccctt aatgctcgcc tgcccctgaa cactgatgcc      300

tacttgtccc tccaagaact ccagggtcag gacccaactc acttggtgta g               351


<210> 76
<211> 414
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 76
aataagcgag acctaattaa aaaacacatc tggcctaatg ttccagatcc ttcaaagagt       60

catattgccc agtggtcacc tcacactcct ccaaggcaca atttcaattc aaaggatcaa      120

atgtattcag atggcaattt cactgatgta agtgttgtgg aaatagaagc aaatgacaaa      180

aagccttttc cagaagatct gaaatcattg gacctgttca aaaaggaaaa aattaatact      240

gaaggacaca gcagtggtat tggggggtct tcatgtatgt catcttctag gccaagcatt      300

tctagcagtg atgaaaatga atcttcacaa aacacttcga gcactgtcca gtattctacc      360

gtggtacaca gtggctacag acaccaagtt ccgtcagtcc aagtcttctc aaga            414


<210> 77
<211> 618
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 77
gcatccttaa gcagcaacca ctcgctgacc agctgcttca ccaaccaggg ttacttcttc       60

ttccacctcc cggatgcctt ggagatagag gcctgccagg tgtactttac ttacgacccc      120

tactcagagg aagaccctga tgagggtgtg gccggggcac ccacagggtc ttccccccaa      180

cccctgcagc ctctgtcagg ggaggacgac gcctactgca ccttcccctc cagggatgac      240

ctgctgctct tctcccccag tctcctcggt ggccccagcc ccccaagcac tgcccctggg      300

ggcagtgggg ccggtgaaga gaggatgccc ccttctttgc aagaaagagt ccccagagac      360

tgggaccccc agcccctggg gcctcccacc ccaggagtcc cagacctggt ggattttcag      420

ccaccccctg agctggtgct gcgagaggct ggggaggagg tccctgacgc tggccccagg      480

gagggagtca gtttcccctg gtccaggcct cctgggcagg gggagttcag ggcccttaat      540

gctcgcctgc ccctgaacac tgatgcctac ttgtccctcc aagaactcca gggtcaggac      600

ccaactcact tggtgtag                                                    618


<210> 78
<211> 186
<212> DNA
<213> Homo sapiens

<400> 78
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccat                                                                 186


<210> 79
<211> 204
<212> DNA
<213> Homo sapiens

<400> 79
agtggcaaga atgggcctca tgtgtaccag gacctcctgc ttagccttgg gactacaaac       60

agcacgctgc cccctccatt ttctctccaa tctggaatcc tgacattgaa cccagttgct      120

cagggtcagc ccattcttac ttccctggga tcaaatcaag aagaagcata tgtcaccatg      180

tccagcttct accaaaacca gtga                                             204


<210> 80
<211> 279
<212> DNA
<213> Homo sapiens

<400> 80
agccccaaca ggaagaatcc cctctggcca agtgtcccag acccagctca cagcagcctg       60

ggctcctggg tgcccacaat catggaggag gatgccttcc agctgcccgg ccttggcacg      120

ccacccatca ccaagctcac agtgctggag gaggatgaaa agaagccggt gccctgggag      180

tcccataaca gctcagagac ctgtggcctc cccactctgg tccagaccta tgtgctccag      240

ggggacccaa gagcagtttc cacccagccc caatcccag                             279


<210> 81
<211> 234
<212> DNA
<213> Homo sapiens

<400> 81
tcctcttcca ggtccctaga ctgcagggag agtggcaaga atgggcctca tgtgtaccag       60

gacctcctgc ttagccttgg gactacaaac agcacgctgc cccctccatt ttctctccaa      120

tctggaatcc tgacattgaa cccagttgct cagggtcagc ccattcttac ttccctggga      180

tcaaatcaag aagaagcata tgtcaccatg tccagcttct accaaaacca gtga            234


<210> 82
<211> 40
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 82
Ala Ala Ala Glu Asn Leu Tyr Phe Gln Gly Ser Ala Trp Ser His Pro 
1               5                   10                  15      


Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Ala 
            20                  25                  30          


Trp Ser His Pro Gln Phe Glu Lys 
        35                  40  


<210> 83
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 83
His His His His His His Ser Ser Gly Arg Glu Asn Leu Tyr Phe Gln 
1               5                   10                  15      


Gly Ser Met Gly 
            20  


<210> 84
<211> 9
<212> PRT
<213> Homo sapiens

<400> 84
Ile Trp Pro Asn Val Pro Asp Pro Ser 
1               5                   


<210> 85
<211> 9
<212> PRT
<213> Homo sapiens

<400> 85
Leu Lys Cys Asn Thr Pro Asp Pro Ser 
1               5                   


<210> 86
<211> 9
<212> PRT
<213> Homo sapiens

<400> 86
Lys Ile Trp Ala Val Pro Ser Pro Glu 
1               5                   


<210> 87
<211> 9
<212> PRT
<213> Homo sapiens

<400> 87
Cys Ser Arg Glu Ile Pro Asp Pro Ala 
1               5                   


<210> 88
<211> 9
<212> PRT
<213> Homo sapiens

<400> 88
Val Trp Pro Ser Leu Pro Asp His Lys 
1               5                   


<210> 89
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 89
His His His His His His 
1               5       


<210> 90
<211> 175
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 90
Met Thr Pro Leu Gly Pro Ala Ser Ser Leu Pro Gln Ser Phe Leu Leu 
1               5                   10                  15      


Lys Cys Leu Glu Gln Val Arg Lys Ile Gln Gly Asp Gly Ala Ala Leu 
            20                  25                  30          


Gln Glu Lys Leu Cys Ala Thr Tyr Lys Leu Cys His Pro Glu Glu Leu 
        35                  40                  45              


Val Leu Leu Gly His Ser Leu Gly Ile Pro Trp Ala Pro Leu Ser Ser 
    50                  55                  60                  


Cys Pro Ser Gln Ala Leu Gln Leu Ala Gly Cys Leu Ser Gln Leu His 
65                  70                  75                  80  


Ser Gly Leu Phe Leu Tyr Gln Gly Leu Leu Gln Ala Leu Glu Gly Ile 
                85                  90                  95      


Ser Pro Glu Leu Gly Pro Thr Leu Asp Thr Leu Gln Leu Asp Val Ala 
            100                 105                 110         


Asp Phe Ala Thr Thr Ile Trp Gln Gln Met Glu Glu Leu Gly Met Ala 
        115                 120                 125             


Pro Ala Leu Gln Pro Thr Gln Gly Ala Met Pro Ala Phe Ala Ser Ala 
    130                 135                 140                 


Phe Gln Arg Arg Ala Gly Gly Val Leu Val Ala Ser His Leu Gln Ser 
145                 150                 155                 160 


Phe Leu Glu Val Ser Tyr Arg Val Leu Arg His Leu Ala Gln Pro 
                165                 170                 175 


