                               SEQUENCE LISTING

<110> SIRNAOMICS, INC.
 
<120> OLIGONUCLEOTIDES WITH NUCLEOSIDE ANALOGS

<130> 4690.0015I

<140> PCT/US2020/054093
<141> 2020-10-02

<150> 62/977,630
<151> 2020-02-17

<150> 62/927,500
<151> 2019-10-29

<150> 62/909,526
<151> 2019-10-02

<160> 41    

<170> PatentIn version 3.5

<210> 1
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (22)..(22)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 1
ccuguggaau aguacuuacu gcaau                                             25


<210> 2
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 2
auugcaguaa guacuauucc acagg                                             25


<210> 3
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (15)..(15)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (22)..(22)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (26)..(27)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 3
ccuguggaau aguacuuacu gcaaucc                                           27


<210> 4
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 4
auugauacag aucucuuucu u                                                 21


<210> 5
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
aagaaagaga ucuguaucaa u                                                 21


<210> 6
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 6
gggagaaggt gcctatggag aagtt                                             25


<210> 7
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 7
ggagaagttc aacttgctgt gaata                                             25


<210> 8
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ccagttgatg tttggtcctg tggaa                                             25


<210> 9
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 9
cctgtggaat agtacttact gcaat                                             25


<210> 10
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 10
ggaataactc acagggata                                                    19


<210> 11
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 11
gggatattaa accagaaaa                                                    19


<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 12
gcagaaccag ttgatgttt                                                    19


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
ggaatagtac ttactgcaa                                                    19


<210> 14
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 14
uuggaauaac uccacgggau a                                                 21


<210> 15
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(23)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 15
aagaaagaga ucuguaucaa ucctt                                             25


<210> 16
<211> 27
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(25)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 16
aagaaagaga ucuguaucaa ucccctt                                           27


<210> 17
<211> 29
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(27)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 17
aagaaagaga ucuguaucaa ucccccctt                                         29


<210> 18
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 18
ccuguggaau aguacuuacu gcaau                                             25


<210> 19
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (26)..(27)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 19
ccuguggaau aguacuuacu gcaaucc                                           27


<210> 20
<211> 23
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (13)..(13)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (17)..(17)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (20)..(20)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 20
uguggaauag uacuuacugc aau                                               23


<210> 21
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (24)..(25)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 21
uguggaauag uacuuacugc aaucc                                             25


<210> 22
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (1)..(2)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (19)..(19)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (22)..(22)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 22
ccuguggaau aguacuuacu gcaau                                             25


<210> 23
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 23
ccaacaauua ugaugaaauu ucuua                                             25


<210> 24
<211> 27
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (26)..(27)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 24
ccaacaauua ugaugaaauu ucuuacc                                           27


<210> 25
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 25
auugcaguaa guacuauucc acagg                                             25


<210> 26
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 26
uaagaaauuu caucauaauu guugg                                             25


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Asn Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210> 28
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> D-amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> D-amino acid

<400> 28
Asn Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> D-amino acid

<220>
<221> MOD_RES
<222> (20)..(20)
<223> D-amino acid

<400> 29
Asn Ala Val Pro Asn Leu Arg Gly Asp Leu Gln Val Leu Ala Gln Lys 
1               5                   10                  15      


Val Ala Arg Thr 
            20  


<210> 30
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (12)..(12)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (18)..(18)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 30
aagaaagaga ucuguaucaa utt                                               23


<210> 31
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 31
auugauacag aucucuuucu utt                                               23


<210> 32
<211> 25
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (5)..(5)
<223> 2', 2'-difluoro 2'-deoxycytidine

<220>
<221> modified_base
<222> (22)..(22)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 32
ccaacaauua ugaugaaauu ucuua                                             25


<210> 33
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Lys His His His Lys His His His Lys His His His Lys His His His 
1               5                   10                  15      


Lys 
    


<210> 34
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Lys His His His Lys His His His Asn His His His Asn His His His 
1               5                   10                  15      


Asn 
    


<210> 35
<211> 81
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (2)..(6)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (7)..(9)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (10)..(14)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (15)..(17)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (18)..(22)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (23)..(25)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (26)..(30)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (31)..(33)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (34)..(38)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (39)..(41)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (42)..(46)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (47)..(49)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (50)..(54)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (55)..(57)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (58)..(62)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (63)..(65)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (66)..(70)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (71)..(73)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (74)..(78)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (79)..(81)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (2)..(81)
<223> This region may encompass 3-10 "(H)n(K)m" units, wherein
      n = 1-5 and m = 0-3

<400> 35
Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
1               5                   10                  15      


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
            20                  25                  30          


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
        35                  40                  45              


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
    50                  55                  60                  


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
65                  70                  75                  80  


Lys 
    


<210> 36
<211> 82
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (2)..(6)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (7)..(9)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (10)..(14)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (15)..(17)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (18)..(22)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (23)..(25)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (26)..(30)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (31)..(33)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (34)..(38)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (39)..(41)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (42)..(46)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (47)..(49)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (50)..(54)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (55)..(57)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (58)..(62)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (63)..(65)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (66)..(70)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (71)..(73)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (74)..(78)
<223> This region may encompass 1-5 residues

<220>
<221> MISC_FEATURE
<222> (79)..(81)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (2)..(81)
<223> This region may encompass 3-10 "(H)n(K)m" units, wherein
      n = 1-5 and m = 0-3

<400> 36
Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
1               5                   10                  15      


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
            20                  25                  30          


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
        35                  40                  45              


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
    50                  55                  60                  


Lys His His His His His Lys Lys Lys His His His His His Lys Lys 
65                  70                  75                  80  


Lys Cys 
        


<210> 37
<211> 281
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (2)..(5)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (6)..(8)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (9)..(12)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (13)..(15)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (16)..(19)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (20)..(22)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (23)..(26)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (27)..(29)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (30)..(33)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (34)..(36)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (37)..(40)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (41)..(43)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (44)..(47)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (48)..(50)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (51)..(54)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (55)..(57)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (58)..(61)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (62)..(64)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (65)..(68)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (69)..(71)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (72)..(75)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (76)..(78)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (79)..(82)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (83)..(85)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (86)..(89)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (90)..(92)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (93)..(96)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (97)..(99)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (100)..(103)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (104)..(106)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (107)..(110)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (111)..(113)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (114)..(117)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (118)..(120)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (121)..(124)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (125)..(127)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (128)..(131)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (132)..(134)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (135)..(138)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (139)..(141)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (142)..(145)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (146)..(148)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (149)..(152)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (153)..(155)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (156)..(159)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (160)..(162)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (163)..(166)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (167)..(169)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (170)..(173)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (174)..(176)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (177)..(180)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (181)..(183)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (184)..(187)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (188)..(190)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (191)..(194)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (195)..(197)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (198)..(201)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (202)..(204)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (205)..(208)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (209)..(211)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (212)..(215)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (216)..(218)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (219)..(222)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (223)..(225)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (226)..(229)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (230)..(232)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (233)..(236)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (237)..(239)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (240)..(243)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (244)..(246)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (247)..(250)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (251)..(253)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (254)..(257)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (258)..(260)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (261)..(264)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (265)..(267)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (268)..(271)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (272)..(274)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (275)..(278)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (279)..(281)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (2)..(281)
<223> This region may encompass 3-10 "(H)a(K)m(H)b(K)m(H)c(K)m(H)d
      (K)m" units, wherein a, b, c, and d = 3 or 4 and m = 0-3

<400> 37
Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
1               5                   10                  15      


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
            20                  25                  30          


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
        35                  40                  45              


Lys Lys His His His His Lys Lys Lys His His His His Lys Lys Lys 
    50                  55                  60                  


His His His His Lys Lys Lys His His His His Lys Lys Lys His His 
65                  70                  75                  80  


His His Lys Lys Lys His His His His Lys Lys Lys His His His His 
                85                  90                  95      


Lys Lys Lys His His His His Lys Lys Lys His His His His Lys Lys 
            100                 105                 110         


Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
        115                 120                 125             


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
    130                 135                 140                 


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
145                 150                 155                 160 


Lys Lys His His His His Lys Lys Lys His His His His Lys Lys Lys 
                165                 170                 175     


His His His His Lys Lys Lys His His His His Lys Lys Lys His His 
            180                 185                 190         


His His Lys Lys Lys His His His His Lys Lys Lys His His His His 
        195                 200                 205             


Lys Lys Lys His His His His Lys Lys Lys His His His His Lys Lys 
    210                 215                 220                 


Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
225                 230                 235                 240 


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
                245                 250                 255     


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
            260                 265                 270         


Lys Lys His His His His Lys Lys Lys 
        275                 280     


<210> 38
<211> 282
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MISC_FEATURE
<222> (1)..(1)
<223> May or may not be present

<220>
<221> MISC_FEATURE
<222> (2)..(5)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (6)..(8)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (9)..(12)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (13)..(15)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (16)..(19)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (20)..(22)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (23)..(26)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (27)..(29)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (30)..(33)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (34)..(36)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (37)..(40)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (41)..(43)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (44)..(47)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (48)..(50)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (51)..(54)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (55)..(57)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (58)..(61)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (62)..(64)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (65)..(68)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (69)..(71)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (72)..(75)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (76)..(78)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (79)..(82)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (83)..(85)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (86)..(89)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (90)..(92)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (93)..(96)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (97)..(99)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (100)..(103)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (104)..(106)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (107)..(110)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (111)..(113)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (114)..(117)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (118)..(120)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (121)..(124)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (125)..(127)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (128)..(131)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (132)..(134)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (135)..(138)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (139)..(141)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (142)..(145)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (146)..(148)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (149)..(152)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (153)..(155)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (156)..(159)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (160)..(162)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (163)..(166)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (167)..(169)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (170)..(173)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (174)..(176)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (177)..(180)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (181)..(183)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (184)..(187)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (188)..(190)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (191)..(194)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (195)..(197)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (198)..(201)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (202)..(204)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (205)..(208)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (209)..(211)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (212)..(215)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (216)..(218)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (219)..(222)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (223)..(225)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (226)..(229)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (230)..(232)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (233)..(236)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (237)..(239)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (240)..(243)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (244)..(246)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (247)..(250)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (251)..(253)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (254)..(257)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (258)..(260)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (261)..(264)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (265)..(267)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (268)..(271)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (272)..(274)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (275)..(278)
<223> This region may encompass 3 or 4 residues

<220>
<221> MISC_FEATURE
<222> (279)..(281)
<223> This region may encompass 0-3 residues

<220>
<221> MISC_FEATURE
<222> (2)..(281)
<223> This region may encompass 3-10 "(H)a(K)m(H)b(K)m(H)c(K)m(H)d
      (K)m" units, wherein a, b, c, and d = 3 or 4 and m = 0-3

<400> 38
Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
1               5                   10                  15      


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
            20                  25                  30          


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
        35                  40                  45              


Lys Lys His His His His Lys Lys Lys His His His His Lys Lys Lys 
    50                  55                  60                  


His His His His Lys Lys Lys His His His His Lys Lys Lys His His 
65                  70                  75                  80  


His His Lys Lys Lys His His His His Lys Lys Lys His His His His 
                85                  90                  95      


Lys Lys Lys His His His His Lys Lys Lys His His His His Lys Lys 
            100                 105                 110         


Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
        115                 120                 125             


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
    130                 135                 140                 


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
145                 150                 155                 160 


Lys Lys His His His His Lys Lys Lys His His His His Lys Lys Lys 
                165                 170                 175     


His His His His Lys Lys Lys His His His His Lys Lys Lys His His 
            180                 185                 190         


His His Lys Lys Lys His His His His Lys Lys Lys His His His His 
        195                 200                 205             


Lys Lys Lys His His His His Lys Lys Lys His His His His Lys Lys 
    210                 215                 220                 


Lys His His His His Lys Lys Lys His His His His Lys Lys Lys His 
225                 230                 235                 240 


His His His Lys Lys Lys His His His His Lys Lys Lys His His His 
                245                 250                 255     


His Lys Lys Lys His His His His Lys Lys Lys His His His His Lys 
            260                 265                 270         


Lys Lys His His His His Lys Lys Lys Cys 
        275                 280         


<210> 39
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(23)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 39
aagaaagaga ucuguaucaa ucctt                                             25


<210> 40
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide

<400> 40
aagaaagaga ucuguaucaa utt                                               23


<210> 41
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<220>
<223> Description of Combined DNA/RNA Molecule: Synthetic
      oligonucleotide


<220>
<221> modified_base
<222> (22)..(23)
<223> 2', 2'-difluoro 2'-deoxycytidine

<400> 41
auugauacag aucucuuucu ucctt                                             25


