                         SEQUENCE LISTING

<110>  Janssen Vaccines & Prevention
       University of Chicago
 
<120>  Staphylococcus Peptides and Methods of Use

<130>  004852.150WO1

<150>  US62/909458
<151>  2019-10-02

<150>  US62/909473
<151>  2019-10-02

<160>  108   

<170>  PatentIn version 3.5

<210>  1
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA consensus


<220>
<221>  misc_feature
<222>  (63)..(63)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Xaa Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  2
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  2

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  3
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  3

Met Lys Asn Lys Lys Arg Val Phe Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Asn Thr Glu Ala Asn Ser Ala Asn Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys Ala Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr Pro Gly Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Val Ser Glu 
65                  70                  75                  80  


Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Arg Asn Glu Thr Asn 
        115                 120                 125             


Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Leu Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Arg His Val His Trp Ser Val Val Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn Asp Glu Phe Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser Asn Glu Lys Thr Arg 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Lys Pro 
    290                 295                 300                 


Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  4
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  4

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Val Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Glu Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asn Lys Ser Phe Arg Glu Gly 
            340                 345                 350 


<210>  5
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  5

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Glu Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Thr Asp Asn Lys Ser Phe Arg Glu Gly 
            340                 345                 350 


<210>  6
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  6

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Val Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Glu Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asn Lys Ser Phe Arg Glu Gly 
            340                 345                 350 


<210>  7
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  7

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Val Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  8
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  8

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Val Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Lys Tyr Asp Thr Ile Ala Ile 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  9
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  9

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Ala Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  10
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  10

Met Lys Asn Lys Lys Arg Val Phe Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Asn Thr Glu Ala Asn Ser Ala Asn Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys Ala Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr Pro Gly Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Val Ser Glu 
65                  70                  75                  80  


Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Arg Asn Glu Thr Asn 
        115                 120                 125             


Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Leu Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Arg His Val His Trp Ser Val Val Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn Asp Glu Phe Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Thr Asn Asp Lys Thr Arg 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Lys Pro 
    290                 295                 300                 


Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  11
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  11

Met Lys Asn Lys Lys Arg Val Phe Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Asn Thr Glu Ala Asn Ser Ala Asn Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys Ala Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr Pro Gly Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Asn Asn 
        115                 120                 125             


Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Ser Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Asn Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Val Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Asp Phe Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Val Leu Lys Asn Lys Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Ile Asp Lys Tyr Ser Asp Glu Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  12
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  12

Met Lys Asn Lys Lys Arg Val Phe Ile Ala Ser Ser Leu Ser Cys Val 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Asn Thr Glu Ala Asn Ser Ala Asn Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys Ala Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr Pro Gly Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Val Ser Glu 
65                  70                  75                  80  


Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Arg Asn Glu Thr Asn 
        115                 120                 125             


Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Leu Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Arg His Val His Trp Ser Val Val Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn Asp Glu Phe Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser Asn Glu Lys Thr Arg 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Lys Pro 
    290                 295                 300                 


Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  13
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  13

Met Lys Asn Lys Lys Arg Val Phe Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ala Ala Asn Thr Glu Ala Asn Ser Ala Asn Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val Asp Lys Ala Gln Gln 
        35                  40                  45              


Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys Asn Thr Pro Gly Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Ile Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Asn Asn 
        115                 120                 125             


Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Asn Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Val Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Phe Leu Phe 
225                 230                 235                 240 


Tyr Arg Thr Thr Arg Leu Ser Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Lys Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Ile Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  14
<211>  351
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukA

<400>  14

Met Lys Asn Lys Lys Arg Val Leu Ile Ala Ser Ser Leu Ser Cys Ala 
1               5                   10                  15      


Ile Leu Leu Leu Ser Ala Ala Thr Thr Gln Ala Asn Ser Ala His Lys 
            20                  25                  30          


Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val Asp Lys Ser Gln Gln 
        35                  40                  45              


Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys Asn Ser Thr Val Pro 
    50                  55                  60                  


Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys Arg Thr Glu Thr Val 
65                  70                  75                  80  


Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu Gln Phe Asp Phe Ile 
                85                  90                  95      


Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu Val Lys Lys Gln Gly 
            100                 105                 110         


Ser Ile His Ser Asn Leu Lys Phe Glu Ser His Lys Glu Glu Lys Asn 
        115                 120                 125             


Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His Val Asp Phe Gln Val 
    130                 135                 140                 


Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln Leu Pro Lys Asn Lys 
145                 150                 155                 160 


Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser Tyr Ser Ser Gly Gly 
                165                 170                 175     


Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr Ser Ser Asn Ser Tyr 
            180                 185                 190         


Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Asp Thr Ile Ala Ser 
        195                 200                 205             


Gly Lys Asn Asn Asn Trp His Val His Trp Ser Val Ile Ala Asn Asp 
    210                 215                 220                 


Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn Asp Glu Leu Leu Phe 
225                 230                 235                 240 


Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn Pro Glu Leu Ser Phe 
                245                 250                 255     


Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg Ser Gly Phe Asn Pro 
            260                 265                 270         


Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser Asn Glu Lys Thr Gln 
        275                 280                 285             


Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile Leu Lys Asn Arg Pro 
    290                 295                 300                 


Gly Ile His Tyr Ala Pro Ser Ile Leu Glu Lys Asn Lys Asp Gly Gln 
305                 310                 315                 320 


Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys Asn Lys Thr Val Lys 
                325                 330                 335     


Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro Tyr Lys Glu Gly 
            340                 345                 350     


<210>  15
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA consensus


<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Xaa Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  16
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  16

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  17
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  17

Asn Ser Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys 
            20                  25                  30          


Asn Thr Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys 
        35                  40                  45              


Arg Thr Val Ser Glu Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Arg Asn Glu Thr Asn Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Leu Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Arg His Val His Trp Ser 
            180                 185                 190         


Val Val Ala Asn Asp Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Arg Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Lys Pro Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  18
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  18

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Val Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Glu Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asn Lys Ser Phe 
305                 310                 315                 320 


Arg Glu Gly 
            


<210>  19
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  19

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Glu Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Thr Asp Asn Lys Ser Phe 
305                 310                 315                 320 


Arg Glu Gly 
            


<210>  20
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  20

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Glu Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Val Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Glu Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asn Lys Ser Phe 
305                 310                 315                 320 


Arg Glu Gly 
            


<210>  21
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  21

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Val Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  22
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  22

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Val Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Lys Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ile Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  23
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  23

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Ala Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  24
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  24

Asn Ser Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys 
            20                  25                  30          


Asn Thr Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys 
        35                  40                  45              


Arg Thr Val Ser Glu Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Arg Asn Glu Thr Asn Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Leu Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Arg His Val His Trp Ser 
            180                 185                 190         


Val Val Ala Asn Asp Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Thr 
                245                 250                 255     


Asn Asp Lys Thr Arg Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Lys Pro Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  25
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  25

Asn Ser Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys 
            20                  25                  30          


Asn Thr Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Asn Asn Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Ser Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Asn Ser Gly Gly Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Val Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Asp Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Val 
            260                 265                 270         


Leu Lys Asn Lys Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Ile Asp Lys Tyr Ser Asp Glu Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  26
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  26

Asn Ser Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys 
            20                  25                  30          


Asn Thr Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys 
        35                  40                  45              


Arg Thr Val Ser Glu Tyr Asp Lys Glu Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Arg Asn Glu Thr Asn Ala Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Gln Arg Asn Pro Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Leu Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Ser Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Arg His Val His Trp Ser 
            180                 185                 190         


Val Val Ala Asn Asp Leu Lys Tyr Gly Asn Glu Ile Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Phe Leu Phe Tyr Arg Asn Thr Arg Leu Ser Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Ile Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Arg Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Lys Pro Gly Ile His Tyr Gly Gln Pro Ile Leu Glu Gln 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Phe Ile Val Val Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Glu Lys Tyr Ser Asp Gln Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  27
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  27

Asn Ser Ala Asn Lys Asp Ser Gln Asp Gln Thr Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ala Gln Gln Lys Glu Lys Arg Asn Val Asn Asp Lys Asp Lys 
            20                  25                  30          


Asn Thr Pro Gly Pro Asp Asp Ile Gly Lys Asn Gly Lys Val Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Ile Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Asn Asn Ser Ser Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Asn Ser Gly Gly Lys Phe Asp Ser Val Lys Gly Val Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Val Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Phe Leu Phe Tyr Arg Thr Thr Arg Leu Ser Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Lys Pro Gly Ile His Tyr Ala Pro Pro Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Ile Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  28
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukA

<400>  28

Asn Ser Ala His Lys Asp Ser Gln Asp Gln Asn Lys Lys Glu His Val 
1               5                   10                  15      


Asp Lys Ser Gln Gln Lys Asp Lys Arg Asn Val Thr Asn Lys Asp Lys 
            20                  25                  30          


Asn Ser Thr Val Pro Asp Asp Ile Gly Lys Asn Gly Lys Ile Thr Lys 
        35                  40                  45              


Arg Thr Glu Thr Val Tyr Asp Glu Lys Thr Asn Ile Leu Gln Asn Leu 
    50                  55                  60                  


Gln Phe Asp Phe Ile Asp Asp Pro Thr Tyr Asp Lys Asn Val Leu Leu 
65                  70                  75                  80  


Val Lys Lys Gln Gly Ser Ile His Ser Asn Leu Lys Phe Glu Ser His 
                85                  90                  95      


Lys Glu Glu Lys Asn Ser Asn Trp Leu Lys Tyr Pro Ser Glu Tyr His 
            100                 105                 110         


Val Asp Phe Gln Val Lys Arg Asn Arg Lys Thr Glu Ile Leu Asp Gln 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Ser Thr Ala Lys Val Asp Ser Thr Phe Ser 
    130                 135                 140                 


Tyr Ser Ser Gly Gly Lys Phe Asp Ser Thr Lys Gly Ile Gly Arg Thr 
145                 150                 155                 160 


Ser Ser Asn Ser Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr 
                165                 170                 175     


Asp Thr Ile Ala Ser Gly Lys Asn Asn Asn Trp His Val His Trp Ser 
            180                 185                 190         


Val Ile Ala Asn Asp Leu Lys Tyr Gly Gly Glu Val Lys Asn Arg Asn 
        195                 200                 205             


Asp Glu Leu Leu Phe Tyr Arg Asn Thr Arg Ile Ala Thr Val Glu Asn 
    210                 215                 220                 


Pro Glu Leu Ser Phe Ala Ser Lys Tyr Arg Tyr Pro Ala Leu Val Arg 
225                 230                 235                 240 


Ser Gly Phe Asn Pro Glu Phe Leu Thr Tyr Leu Ser Asn Glu Lys Ser 
                245                 250                 255     


Asn Glu Lys Thr Gln Phe Glu Val Thr Tyr Thr Arg Asn Gln Asp Ile 
            260                 265                 270         


Leu Lys Asn Arg Pro Gly Ile His Tyr Ala Pro Ser Ile Leu Glu Lys 
        275                 280                 285             


Asn Lys Asp Gly Gln Arg Leu Ile Val Thr Tyr Glu Val Asp Trp Lys 
    290                 295                 300                 


Asn Lys Thr Val Lys Val Val Asp Lys Tyr Ser Asp Asp Asn Lys Pro 
305                 310                 315                 320 


Tyr Lys Glu Gly 
                


<210>  29
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB consensus

<400>  29

Met Ile Lys Gln Leu Cys Lys Asn Ile Thr Ile Cys Ser Leu Ala Leu 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Thr Ser Tyr Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
            260                 265                 270         


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  30
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  30

Met Ile Lys Gln Val Cys Lys Asn Ile Thr Ile Cys Ser Leu Ala Leu 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Ser Ser Tyr Ala Glu Ile Lys 
            20                  25                  30          


Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys Lys Ile Ser 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Lys Ile 
                85                  90                  95      


Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Ser Thr Asn 
        115                 120                 125             


Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys 
    130                 135                 140                 


Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly 
145                 150                 155                 160 


Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser Glu Thr Ile 
                165                 170                 175     


Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr 
            180                 185                 190         


Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile Asn Asn Met 
        195                 200                 205             


Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val 
    210                 215                 220                 


Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys 
225                 230                 235                 240 


Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly 
                245                 250                 255     


Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Asn Asp Lys 
            260                 265                 270         


Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met Asp Asp Phe 
        275                 280                 285             


Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu 
    290                 295                 300                 


Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val 
305                 310                 315                 320 


Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Phe Asn Asp Lys 
                325                 330                 335     


Glu Lys Lys 
            


<210>  31
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  31

Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
1               5                   10                  15      


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
            20                  25                  30          


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
        35                  40                  45              


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
    50                  55                  60                  


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
65                  70                  75                  80  


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
                85                  90                  95      


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
            100                 105                 110         


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
        115                 120                 125             


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
    130                 135                 140                 


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
145                 150                 155                 160 


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
                165                 170                 175     


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
            180                 185                 190         


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
        195                 200                 205             


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
    210                 215                 220                 


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
225                 230                 235                 240 


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
                245                 250                 255     


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
            260                 265                 270         


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
        275                 280                 285             


Lys Lys 
    290 


<210>  32
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  32

Met Ile Lys Gln Val Cys Lys Asn Ile Thr Ile Cys Ser Leu Ala Leu 
1               5                   10                  15      


Ser Thr Ala Leu Thr Ile Phe Pro Ala Ser Ser Tyr Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Glu Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Lys Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Glu Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Gln Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr Asn 
            180                 185                 190         


Lys Gly Val Ala Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu Gly 
            260                 265                 270         


Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Ile Lys Val Leu Asn Asp Lys Glu 
                325                 330                 335     


Lys Lys 
        


<210>  33
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  33

Met Ile Lys Gln Val Cys Lys Asn Ile Thr Ile Cys Ser Leu Ala Leu 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Ser Ser Tyr Ala Glu Ile Lys 
            20                  25                  30          


Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys Lys Ile Ser 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Lys Ile 
                85                  90                  95      


Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Thr Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Ser Thr Asn 
        115                 120                 125             


Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys 
    130                 135                 140                 


Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly 
145                 150                 155                 160 


Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser Glu Thr Ile 
                165                 170                 175     


Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr 
            180                 185                 190         


Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile Asn Asn Met 
        195                 200                 205             


Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val 
    210                 215                 220                 


Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys 
225                 230                 235                 240 


Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly 
                245                 250                 255     


Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Asn Asp Lys 
            260                 265                 270         


Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met Asp Asp Phe 
        275                 280                 285             


Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu 
    290                 295                 300                 


Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val 
305                 310                 315                 320 


Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Ile Asn Asp Lys 
                325                 330                 335     


Glu Gln Lys 
            


<210>  34
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  34

Met Ile Lys Gln Leu Cys Lys Asn Ile Thr Ile Cys Thr Leu Ala Leu 
1               5                   10                  15      


Ser Thr Thr Phe Thr Val Leu Pro Ala Thr Ser Phe Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
            260                 265                 270         


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Glu Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  35
<211>  339
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  35

Met Ile Lys Gln Val Cys Lys Asn Ile Thr Ile Cys Ser Leu Ala Leu 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Ser Ser Tyr Ala Glu Ile Lys 
            20                  25                  30          


Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys Lys Ile Ser 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Lys Ile 
                85                  90                  95      


Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Ser Thr Asn 
        115                 120                 125             


Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys 
    130                 135                 140                 


Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly 
145                 150                 155                 160 


Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser Glu Thr Ile 
                165                 170                 175     


Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro Thr Thr 
            180                 185                 190         


Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile Asn Asn Met 
        195                 200                 205             


Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp Arg Val 
    210                 215                 220                 


Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys 
225                 230                 235                 240 


Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly 
                245                 250                 255     


Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Asn Asp Lys 
            260                 265                 270         


Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met Asp Asp Phe 
        275                 280                 285             


Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser Gly Glu 
    290                 295                 300                 


Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val 
305                 310                 315                 320 


Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Ile Asn Asp Lys 
                325                 330                 335     


Glu Gln Lys 
            


<210>  36
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  36

Met Ile Lys Gln Leu Tyr Lys Asn Ile Thr Ile Cys Ser Leu Ala Ile 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Thr Ser Tyr Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
            260                 265                 270         


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asp Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  37
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  37

Met Ile Lys Gln Leu Tyr Lys Asn Ile Thr Ile Cys Thr Leu Ala Leu 
1               5                   10                  15      


Ser Thr Thr Phe Thr Val Leu Pro Ala Thr Ser Tyr Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu Gly 
            260                 265                 270         


Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  38
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  38

Met Ile Lys Gln Leu Tyr Lys Asn Ile Thr Ile Cys Ser Leu Thr Ile 
1               5                   10                  15      


Ser Thr Ala Leu Thr Val Phe Pro Ala Thr Ser Tyr Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Pro Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu Gly 
            260                 265                 270         


Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asp Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  39
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  39

Met Ile Lys Gln Leu Cys Lys Asn Ile Thr Ile Cys Thr Leu Ala Leu 
1               5                   10                  15      


Ser Thr Thr Phe Thr Val Leu Pro Ala Thr Ser Phe Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Glu Gly 
            260                 265                 270         


Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  40
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  40

Met Ile Lys Gln Leu Cys Lys Asn Ile Thr Ile Cys Thr Leu Ala Leu 
1               5                   10                  15      


Ser Thr Thr Phe Thr Val Leu Pro Ala Thr Ser Phe Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
            260                 265                 270         


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  41
<211>  338
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Immature LukB

<400>  41

Met Ile Lys Gln Leu Cys Lys Asn Ile Thr Ile Cys Thr Leu Ala Leu 
1               5                   10                  15      


Ser Thr Thr Phe Thr Val Leu Pro Ala Thr Ser Phe Ala Lys Ile Asn 
            20                  25                  30          


Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly Asp Thr Lys 
        35                  40                  45              


Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys Asn Ile Thr 
    50                  55                  60                  


Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr Asp Lys Glu 
65                  70                  75                  80  


Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly Leu Arg Ile 
                85                  90                  95      


Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp Pro Gly Ser 
            100                 105                 110         


Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn Thr Asn Val 
        115                 120                 125             


Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu Val Lys Tyr 
    130                 135                 140                 


Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn Arg Gly Gly 
145                 150                 155                 160 


Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu Thr Ile Ser 
                165                 170                 175     


Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser Thr Ser His 
            180                 185                 190         


Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn Asn Met Gly 
        195                 200                 205             


His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn Arg Thr Lys 
    210                 215                 220                 


Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp Ala Lys Asp 
225                 230                 235                 240 


Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser Glu Gly Phe 
                245                 250                 255     


Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys Asp Lys Gly 
            260                 265                 270         


Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp Glu Phe Lys 
        275                 280                 285             


Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser Gly Glu Asn 
    290                 295                 300                 


His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr Glu Val Asp 
305                 310                 315                 320 


Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn Asp Asn Glu 
                325                 330                 335     


Lys Lys 
        


<210>  42
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB consensus

<400>  42

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  43
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  43

Glu Ile Lys Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys 
            20                  25                  30          


Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Lys Ile Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Ser Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln 
145                 150                 155                 160 


Pro Thr Thr Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asp Arg Val Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Asn Asp Lys Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Asp Phe Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Phe 
    290                 295                 300                 


Asn Asp Lys Glu Lys Lys 
305                 310 


<210>  44
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  44

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Glu Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Lys Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Glu Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Gln Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln Pro 
145                 150                 155                 160 


Thr Thr Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asp 
            180                 185                 190         


Arg Val Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Glu Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Ile Lys Val Leu Asn 
    290                 295                 300                 


Asp Lys Glu Lys Lys 
305                 


<210>  45
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  45

Glu Ile Lys Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys 
            20                  25                  30          


Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Lys Ile Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Thr Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Ser Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln 
145                 150                 155                 160 


Pro Thr Thr Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asp Arg Val Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Asn Asp Lys Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Asp Phe Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Ile 
    290                 295                 300                 


Asn Asp Lys Glu Gln Lys 
305                 310 


<210>  46
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  46

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Glu Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  47
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  47

Glu Ile Lys Ser Lys Ile Thr Thr Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Thr Glu Lys 
            20                  25                  30          


Lys Ile Ser Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Lys Ile Leu Asn Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Ser Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg 
            100                 105                 110         


Glu Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile 
        115                 120                 125             


Asn Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Lys Asn Tyr Ser 
    130                 135                 140                 


Glu Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Ile Asp Gln 
145                 150                 155                 160 


Pro Thr Thr Asn Lys Gly Val Ala Trp Lys Val Glu Ala His Ser Ile 
                165                 170                 175     


Asn Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp 
            180                 185                 190         


Asp Arg Val Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu 
        195                 200                 205             


Trp Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val 
    210                 215                 220                 


Ser Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys 
225                 230                 235                 240 


Asn Asp Lys Gly Lys Ser Arg Phe Ile Val His Tyr Lys Arg Ser Met 
                245                 250                 255     


Asp Asp Phe Lys Leu Asp Trp Asn Lys His Gly Phe Trp Gly Tyr Trp 
            260                 265                 270         


Ser Gly Glu Asn His Val Asp Gln Lys Glu Glu Lys Leu Ser Ala Leu 
        275                 280                 285             


Tyr Glu Val Asp Trp Lys Thr His Asp Val Lys Leu Ile Lys Thr Ile 
    290                 295                 300                 


Asn Asp Lys Glu Gln Lys 
305                 310 


<210>  48
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  48

Lys Ile Asn Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asp Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  49
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  49

Lys Ile Asn Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Glu Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  50
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  50

Lys Ile Asn Ser Glu Ile Lys Ala Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Pro Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Glu Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asp Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  51
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  51

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asn Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Glu Gly Lys Ser Lys Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  52
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  52

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  53
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature LukB

<400>  53

Lys Ile Asn Ser Glu Ile Lys Gln Val Ser Glu Lys Asn Leu Asp Gly 
1               5                   10                  15      


Asp Thr Lys Met Tyr Thr Arg Thr Ala Thr Thr Ser Asp Ser Gln Lys 
            20                  25                  30          


Asn Ile Thr Gln Ser Leu Gln Phe Asn Phe Leu Thr Glu Pro Asn Tyr 
        35                  40                  45              


Asp Lys Glu Thr Val Phe Ile Lys Ala Lys Gly Thr Ile Gly Ser Gly 
    50                  55                  60                  


Leu Arg Ile Leu Asp Pro Asn Gly Tyr Trp Asn Ser Thr Leu Arg Trp 
65                  70                  75                  80  


Pro Gly Ser Tyr Ser Val Ser Ile Gln Asn Val Asp Asp Asn Asn Asn 
                85                  90                  95      


Thr Asn Val Thr Asp Phe Ala Pro Lys Asn Gln Asp Glu Ser Arg Glu 
            100                 105                 110         


Val Lys Tyr Thr Tyr Gly Tyr Lys Thr Gly Gly Asp Phe Ser Ile Asn 
        115                 120                 125             


Arg Gly Gly Leu Thr Gly Asn Ile Thr Lys Glu Ser Asn Tyr Ser Glu 
    130                 135                 140                 


Thr Ile Ser Tyr Gln Gln Pro Ser Tyr Arg Thr Leu Leu Asp Gln Ser 
145                 150                 155                 160 


Thr Ser His Lys Gly Val Gly Trp Lys Val Glu Ala His Leu Ile Asn 
                165                 170                 175     


Asn Met Gly His Asp His Thr Arg Gln Leu Thr Asn Asp Ser Asp Asn 
            180                 185                 190         


Arg Thr Lys Ser Glu Ile Phe Ser Leu Thr Arg Asn Gly Asn Leu Trp 
        195                 200                 205             


Ala Lys Asp Asn Phe Thr Pro Lys Asp Lys Met Pro Val Thr Val Ser 
    210                 215                 220                 


Glu Gly Phe Asn Pro Glu Phe Leu Ala Val Met Ser His Asp Lys Lys 
225                 230                 235                 240 


Asp Lys Gly Lys Ser Gln Phe Val Val His Tyr Lys Arg Ser Met Asp 
                245                 250                 255     


Glu Phe Lys Ile Asp Trp Asn Arg His Gly Phe Trp Gly Tyr Trp Ser 
            260                 265                 270         


Gly Glu Asn His Val Asp Lys Lys Glu Glu Lys Leu Ser Ala Leu Tyr 
        275                 280                 285             


Glu Val Asp Trp Lys Thr His Asn Val Lys Phe Val Lys Val Leu Asn 
    290                 295                 300                 


Asp Asn Glu Lys Lys 
305                 


<210>  54
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length SpAkkaa

<400>  54

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  55
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA A domain

<400>  55

Asn Asn Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Glu Ser 
    50          


<210>  56
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA B domain

<400>  56

Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  57
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA C domain

<400>  57

Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  58
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA D domain

<400>  58

Gln Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          


Ser Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser 
    50                  


<210>  59
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA E domain

<400>  59

Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn Met 
1               5                   10                  15      


Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
            20                  25                  30          


Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys Leu 
        35                  40                  45              


Asn Asp Ser 
    50      


<210>  60
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E_UoC

<400>  60

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Glu Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Glu Leu Lys Asp Asp 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Glu Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Glu 
        195                 200                 205             


Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Glu Leu Lys Asp Asp Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  61
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T

<400>  61

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Thr Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Thr Leu Lys Asp Asp 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Thr Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Thr 
        195                 200                 205             


Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Thr Leu Lys Asp Asp Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  62
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E A domain

<400>  62

Asn Asn Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Glu Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Glu Ser 
    50          


<210>  63
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E B domain

<400>  63

Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Glu Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  64
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E C domain

<400>  64

Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Glu Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  65
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E E domain

<400>  65

Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn Met 
1               5                   10                  15      


Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Glu Leu Lys 
            20                  25                  30          


Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys Leu 
        35                  40                  45              


Asn Asp Ser 
    50      


<210>  66
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33E D domain

<400>  66

Gln Gln Asn Asn Phe Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          


Glu Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser 
    50                  


<210>  67
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T A domain

<400>  67

Asn Asn Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Thr Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Glu Ser 
    50          


<210>  68
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T B domain

<400>  68

Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Thr Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  69
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T C domain

<400>  69

Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
1               5                   10                  15      


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Thr Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        35                  40                  45              


Leu Asn Asp Ala 
    50          


<210>  70
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T E domain

<400>  70

Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn Met 
1               5                   10                  15      


Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Thr Leu Lys 
            20                  25                  30          


Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys Leu 
        35                  40                  45              


Asn Asp Ser 
    50      


<210>  71
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA S33T D domain

<400>  71

Gln Gln Asn Asn Phe Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile 
1               5                   10                  15      


Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln 
            20                  25                  30          


Thr Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
        35                  40                  45              


Lys Lys Leu Asn Glu Ser 
    50                  


<210>  72
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA Long

<400>  72

Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      


Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          


Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              


Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  


Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  


Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      


Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         


Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             


Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 


Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 


Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         


Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             


Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 


Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 


Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     


Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         


Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             


Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 


Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 


Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     


Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
            340                 345                 350         


Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys 
        355                 360                 365             


Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys 
    370                 375                 380                 


Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly Lys 
385                 390                 395                 400 


Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
                405                 410                 415     


Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn 
            420                 425                 430         


Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp 
        435                 440                 445             


Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val 
    450                 455                 460                 


Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln 
465                 470                 475                 480 


Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val 
                485                 490                 495     


Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg 
            500                 505                 510         


Arg Arg Glu Leu 
        515     


<210>  73
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAXX


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (68)..(69)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (95)..(96)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (126)..(127)

<220>
<221>  MISC_FEATURE
<222>  (153)..(154)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (184)..(185)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (211)..(212)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (269)..(270)
<223>  Any amino acid except Asp

<400>  73

Ala Gln His Asp Glu Ala Xaa Xaa Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Xaa Xaa Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Xaa Xaa Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Xaa Xaa Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Xaa Xaa Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  74
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkkAA

<400>  74

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  75
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR


<220>
<221>  MISC_FEATURE
<222>  (60)..(61)
<223>  Any amino acid except Gln

<400>  75

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Xaa Xaa Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  76
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR

<400>  76

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Lys Arg Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  77
<211>  292
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR

<400>  77

Met Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu 
1               5                   10                  15      


Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser 
            20                  25                  30          


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln 
        35                  40                  45              


Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Lys Arg Asn Asn 
    50                  55                  60                  


Phe Asn Lys Asp Lys Lys Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro 
65                  70                  75                  80  


Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala 
                85                  90                  95      


Ala Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn 
            100                 105                 110         


Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Lys Lys 
        115                 120                 125             


Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln 
    130                 135                 140                 


Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala 
145                 150                 155                 160 


Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys 
                165                 170                 175     


Ala Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile 
            180                 185                 190         


Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
        195                 200                 205             


Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala 
    210                 215                 220                 


Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn 
225                 230                 235                 240 


Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu 
                245                 250                 255     


Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro 
            260                 265                 270         


Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala 
        275                 280                 285             


Gln Ala Pro Lys 
    290         


<210>  78
<211>  291
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (60)..(61)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (68)..(69)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (95)..(96)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (126)..(127)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (153)..(154)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (184)..(185)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (211)..(212)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (269)..(270)
<223>  Any amino acid except Asp

<400>  78

Ala Gln His Asp Glu Ala Xaa Xaa Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Xaa Xaa Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp Xaa Xaa Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn 
65                  70                  75                  80  


Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa 
                85                  90                  95      


Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu 
            100                 105                 110         


Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Xaa Xaa Asn 
        115                 120                 125             


Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg 
    130                 135                 140                 


Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa Pro Ser Gln Ser Ala Asn 
145                 150                 155                 160 


Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala 
                165                 170                 175     


Asp Asn Lys Phe Asn Lys Glu Xaa Xaa Asn Ala Phe Tyr Glu Ile Leu 
            180                 185                 190         


His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        195                 200                 205             


Leu Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys 
    210                 215                 220                 


Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys 
225                 230                 235                 240 


Glu Xaa Xaa Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr 
                245                 250                 255     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Xaa Xaa Pro Ser 
            260                 265                 270         


Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln 
        275                 280                 285             


Ala Pro Lys 
    290     


<210>  79
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR E domain


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  Any amino acid except Asp

<220>
<221>  MISC_FEATURE
<222>  (60)..(61)
<223>  Any amino acid except Gln

<400>  79

Ala Gln His Asp Glu Ala Xaa Xaa Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Xaa Xaa Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp 
65          


<210>  80
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR E domain


<220>
<221>  MISC_FEATURE
<222>  (7)..(8)
<223>  Any amino acid except Gln

<220>
<221>  MISC_FEATURE
<222>  (34)..(35)
<223>  Any amino acid except Asp

<400>  80

Ala Gln His Asp Glu Ala Xaa Xaa Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Xaa Xaa Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Lys Arg Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp 
65          


<210>  81
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpAkR E domain

<400>  81

Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Lys Arg Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp 
65          


<210>  82
<211>  68
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  E domain of SpAkR in examples

<400>  82

Met Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe Tyr Gln Val Leu 
1               5                   10                  15      


Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser 
            20                  25                  30          


Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln 
        35                  40                  45              


Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Lys Arg Asn Asn 
    50                  55                  60                  


Phe Asn Lys Asp 
65              


<210>  83
<211>  67
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA E domain

<400>  83

Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn 
1               5                   10                  15      


Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            20                  25                  30          


Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys 
        35                  40                  45              


Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe 
    50                  55                  60                  


Asn Lys Asp 
65          


<210>  84
<211>  516
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA 252

<400>  84

Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile 
1               5                   10                  15      


Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro 
            20                  25                  30          


Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr 
        35                  40                  45              


Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe 
    50                  55                  60                  


Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly 
65                  70                  75                  80  


Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln 
                85                  90                  95      


Gln Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu 
            100                 105                 110         


Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser 
        115                 120                 125             


Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys 
    130                 135                 140                 


Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys 
145                 150                 155                 160 


Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn 
                165                 170                 175     


Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser 
            180                 185                 190         


Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser Gln 
        195                 200                 205             


Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe 
    210                 215                 220                 


Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly 
225                 230                 235                 240 


Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu 
                245                 250                 255     


Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn 
            260                 265                 270         


Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu 
        275                 280                 285             


Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys 
    290                 295                 300                 


Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu 
305                 310                 315                 320 


Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys 
                325                 330                 335     


Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
            340                 345                 350         


Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
        355                 360                 365             


Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
    370                 375                 380                 


Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
385                 390                 395                 400 


Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys 
                405                 410                 415     


Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val Asn 
            420                 425                 430         


Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala Asp 
        435                 440                 445             


Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu Val 
    450                 455                 460                 


Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala Gln 
465                 470                 475                 480 


Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr Val 
                485                 490                 495     


Phe Gly Gly Leu Ser Leu Ala Leu Gly Ala Ala Leu Leu Ala Gly Arg 
            500                 505                 510         


Arg Arg Glu Leu 
        515     


<210>  85
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA5 (KKAA)

<400>  85

Gly Pro Leu Gly Ser Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe 
1               5                   10                  15      


Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly 
            20                  25                  30          


Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu 
        35                  40                  45              


Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala 
    50                  55                  60                  


Lys Lys Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Ala Ala Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn 
        115                 120                 125             


Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
    130                 135                 140                 


Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser 
                165                 170                 175     


Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala 
            180                 185                 190         


Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn 
        195                 200                 205             


Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu 
    210                 215                 220                 


Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp 
225                 230                 235                 240 


Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
                245                 250                 255     


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            260                 265                 270         


Lys Ala Ala Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        275                 280                 285             


Leu Asn Asp Ala Gln Ala Pro Lys 
    290                 295     


<210>  86
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA5 (RRAA)

<400>  86

Gly Pro Leu Gly Ser Ala Gln His Asp Glu Ala Arg Arg Asn Ala Phe 
1               5                   10                  15      


Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly 
            20                  25                  30          


Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Val Leu 
        35                  40                  45              


Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala 
    50                  55                  60                  


Arg Arg Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Ala Ala Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn 
        115                 120                 125             


Lys Glu Arg Arg Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
    130                 135                 140                 


Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro 
145                 150                 155                 160 


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser 
                165                 170                 175     


Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Arg Arg Asn Ala 
            180                 185                 190         


Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn 
        195                 200                 205             


Gly Phe Ile Gln Ser Leu Lys Ala Ala Pro Ser Gln Ser Ala Asn Leu 
    210                 215                 220                 


Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp 
225                 230                 235                 240 


Asn Lys Phe Asn Lys Glu Arg Arg Asn Ala Phe Tyr Glu Ile Leu His 
                245                 250                 255     


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            260                 265                 270         


Lys Ala Ala Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        275                 280                 285             


Leu Asn Asp Ala Gln Ala Pro Lys 
    290                 295     


<210>  87
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA5 (KKVV)

<400>  87

Gly Pro Leu Gly Ser Ala Gln His Asp Glu Ala Lys Lys Asn Ala Phe 
1               5                   10                  15      


Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly 
            20                  25                  30          


Phe Ile Gln Ser Leu Lys Val Val Pro Ser Gln Ser Ala Asn Val Leu 
        35                  40                  45              


Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala 
    50                  55                  60                  


Lys Lys Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Val Val Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn 
        115                 120                 125             


Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
    130                 135                 140                 


Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Val Val Pro 
145                 150                 155                 160 


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser 
                165                 170                 175     


Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala 
            180                 185                 190         


Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn 
        195                 200                 205             


Gly Phe Ile Gln Ser Leu Lys Val Val Pro Ser Gln Ser Ala Asn Leu 
    210                 215                 220                 


Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp 
225                 230                 235                 240 


Asn Lys Phe Asn Lys Glu Lys Lys Asn Ala Phe Tyr Glu Ile Leu His 
                245                 250                 255     


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            260                 265                 270         


Lys Val Val Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        275                 280                 285             


Leu Asn Asp Ala Gln Ala Pro Lys 
    290                 295     


<210>  88
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SpA5 (RRVV)

<400>  88

Gly Pro Leu Gly Ser Ala Gln His Asp Glu Ala Arg Arg Asn Ala Phe 
1               5                   10                  15      


Tyr Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly 
            20                  25                  30          


Phe Ile Gln Ser Leu Lys Val Val Pro Ser Gln Ser Ala Asn Val Leu 
        35                  40                  45              


Gly Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala 
    50                  55                  60                  


Arg Arg Asn Lys Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile 
65                  70                  75                  80  


Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln 
                85                  90                  95      


Ser Leu Lys Val Val Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala 
            100                 105                 110         


Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn 
        115                 120                 125             


Lys Glu Arg Arg Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu 
    130                 135                 140                 


Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Val Val Pro 
145                 150                 155                 160 


Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn Glu Ser 
                165                 170                 175     


Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Arg Arg Asn Ala 
            180                 185                 190         


Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn 
        195                 200                 205             


Gly Phe Ile Gln Ser Leu Lys Val Val Pro Ser Gln Ser Ala Asn Leu 
    210                 215                 220                 


Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp 
225                 230                 235                 240 


Asn Lys Phe Asn Lys Glu Arg Arg Asn Ala Phe Tyr Glu Ile Leu His 
                245                 250                 255     


Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu 
            260                 265                 270         


Lys Val Val Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys 
        275                 280                 285             


Leu Asn Asp Ala Gln Ala Pro Lys 
    290                 295     


<210>  89
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1095 F primer

<400>  89
agacgatcct tcggtgagc                                                    19


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  1517R primer

<400>  90
gcttttgcaa tgtcatttac tg                                                22


<210>  91
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  arc-up primer

<400>  91
ttgattcacc agcgcgtatt gtc                                               23


<210>  92
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  arc-dn primer

<400>  92
aggtatctgc ttcaatcagc g                                                 21


<210>  93
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aro-up primer

<400>  93
atcggaaatc ctatttcaca ttc                                               23


<210>  94
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  aro-dn primer

<400>  94
ggtgttgtat taataacgat atc                                               23


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  glp-up primer

<400>  95
ctaggaactg caatcttaat cc                                                22


<210>  96
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  glp-dn primer

<400>  96
tggtaaaatc gcatgtccaa ttc                                               23


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gmk-dn primer

<400>  97
atcgttttat cgggaccatc                                                   20


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gmk-dn primer

<400>  98
tcattaacta caacgtaatc gta                                               23


<210>  99
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pta-up primer

<400>  99
gttaaaatcg tattacctga agg                                               23


<210>  100
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  pta-dn primer

<400>  100
gacccttttg ttgaaaagct taa                                               23


<210>  101
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tpi-up primer

<400>  101
tcgttcattc tgaacgtcgt ga                                                22


<210>  102
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  tpi-dn primer

<400>  102
tttgcacctt ctaacaattg tac                                               23


<210>  103
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  yqi-up primer

<400>  103
cagcatacag gacacctatt ggc                                               23


<210>  104
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  yqi-dn primer

<400>  104
cgttgaggaa tcgatactgg aac                                               23


<210>  105
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ext1F primer

<400>  105
ggggaccact ttgtacaaga aagctgggtc atttaagaag attgtttcag atttatg          57


<210>  106
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ext1F primer

<400>  106
atttgtaaag tcatcataat ataacgaatt atgtattgca atactaaaat c                51


<210>  107
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ext2F primer

<400>  107
cgtcgcgaac tataataaaa acaaacaata cacaacgata gatatc                      46


<210>  108
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  ext2R primer

<400>  108
ggggacaagt ttgtacaaaa aagcaggcaa cgaacgccta aagaaattgt ctttgc           56


