                         SEQUENCE LISTING

<110>  Yale University
       Bordey, Angelique
       Lin, Tiffany
       Hsieh, Lawrence
       Nguyen, Lena
 
<120>  Targeting Cap-Dependent Translation to Reduce Seizures in mTOR 
       Disorders

<130>  047162-7233WO1(01240)

<150>  US 62/910,749
<151>  2019-10-04

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Homo sapiens

<220>
<223>  4EBP1

<400>  1

Met Ser Gly Gly Ser Ser Cys Ser Gln Thr Pro Ser Arg Ala Ile Pro 
1               5                   10                  15      


Ala Thr Arg Arg Val Val Leu Gly Asp Gly Val Gln Leu Pro Pro Gly 
            20                  25                  30          


Asp Tyr Ser Thr Thr Pro Gly Gly Thr Leu Phe Ser Thr Thr Pro Gly 
        35                  40                  45              


Gly Thr Arg Ile Ile Tyr Asp Arg Lys Phe Leu Met Glu Cys Arg Asn 
    50                  55                  60                  


Ser Pro Val Thr Lys Thr Pro Pro Arg Asp Leu Pro Thr Ile Pro Gly 
65                  70                  75                  80  


Val Thr Ser Pro Ser Ser Asp Glu Pro Pro Met Glu Ala Ser Gln Ser 
                85                  90                  95      


His Leu Arg Asn Ser Pro Glu Asp Lys Arg Ala Gly Gly Glu Glu Ser 
            100                 105                 110         


Gln Phe Glu Met Asp Ile 
        115             


<210>  2
<211>  217
<212>  PRT
<213>  Homo sapiens

<220>
<223>  EIF4E

<400>  2

Met Ala Thr Val Glu Pro Glu Thr Thr Pro Thr Pro Asn Pro Pro Thr 
1               5                   10                  15      


Thr Glu Glu Glu Lys Thr Glu Ser Asn Gln Glu Val Ala Asn Pro Glu 
            20                  25                  30          


His Tyr Ile Lys His Pro Leu Gln Asn Arg Trp Ala Leu Trp Phe Phe 
        35                  40                  45              


Lys Asn Asp Lys Ser Lys Thr Trp Gln Ala Asn Leu Arg Leu Ile Ser 
    50                  55                  60                  


Lys Phe Asp Thr Val Glu Asp Phe Trp Ala Leu Tyr Asn His Ile Gln 
65                  70                  75                  80  


Leu Ser Ser Asn Leu Met Pro Gly Cys Asp Tyr Ser Leu Phe Lys Asp 
                85                  90                  95      


Gly Ile Glu Pro Met Trp Glu Asp Glu Lys Asn Lys Arg Gly Gly Arg 
            100                 105                 110         


Trp Leu Ile Thr Leu Asn Lys Gln Gln Arg Arg Ser Asp Leu Asp Arg 
        115                 120                 125             


Phe Trp Leu Glu Thr Leu Leu Cys Leu Ile Gly Glu Ser Phe Asp Asp 
    130                 135                 140                 


Tyr Ser Asp Asp Val Cys Gly Ala Val Val Asn Val Arg Ala Lys Gly 
145                 150                 155                 160 


Asp Lys Ile Ala Ile Trp Thr Thr Glu Cys Glu Asn Arg Glu Ala Val 
                165                 170                 175     


Thr His Ile Gly Arg Val Tyr Lys Glu Arg Leu Gly Leu Pro Pro Lys 
            180                 185                 190         


Ile Val Ile Gly Tyr Gln Ser His Ala Asp Thr Ala Thr Lys Ser Gly 
        195                 200                 205             


Ser Thr Thr Lys Asn Arg Phe Val Val 
    210                 215         


