                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  A CRNN LOSS OF FUNCTION RODENT MODEL

<130>  37187PCT (10546WO01)

<150>  62/909,982
<151>  2019-10-03

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  1902
<212>  DNA
<213>  Homo sapiens

<400>  1
actcctcaca ccacttaaca gccacttgtt tcatcccacc tgggcattag gttgacttca       60

aagatgcctc agttactgca aaacattaat gggatcatcg aggccttcag gcgctatgca      120

aggacggagg gcaactgcac agcgctcacc cgaggggagc tgaaaagact cttggagcaa      180

gagtttgccg atgtgattgt gaaaccccac gatccagcaa ctgtggatga ggtcctgcgt      240

ctgctggatg aagaccacac agggactgtg gaattcaagg aattcctggt cttagtgttt      300

aaagttgccc aggcctgttt caagacactg agcgagagtg ctgagggagc ctgcggctct      360

caagagtctg gaagcctcca ctctggggcc tcgcaggagc tgggcgaagg acagagaagt      420

ggcactgaag tgggaagggc ggggaaaggg cagcattatg aggggagcag ccacagacag      480

agccagcagg gttccagagg gcagaacagg cctggggttc agacccaggg tcaggccact      540

ggctctgcgt gggtcagcag ctatgacagg caagctgagt cccagagcca ggaaagaata      600

agcccgcaga tacaactctc tgggcagaca gagcagaccc agaaagctgg agaaggcaag      660

aggaatcaga caacagagat gaggccagag agacagccac agaccaggga acaggacaga      720

gcccaccaga caggtgagac tgtgactgga tctggaactc agacccaggc aggtgccacc      780

cagactgtgg agcaggacag cagccaccag acaggaagaa ccagcaagca gacacaggag      840

gccaccaatg accagaacag agggactgag acccacggtc aaggcaggag ccagaccagc      900

caggctgtga caggaggaca tgctcagata caggcaggga cacacaccca gacacccacc      960

cagaccgtgg agcaggacag cagccaccag acaggaagca ccagcaccca gacacaggag     1020

tccaccaatg gccagaacag agggactgag atccacggtc aaggcaggag ccagaccagc     1080

caggctgtga caggaggaca cactcagata caggcagggt cacacaccga gactgtggag     1140

caggacagaa gccaaactgt aagccacgga ggggctagag aacagggaca gacccagacg     1200

cagccaggca gtggtcaaag atggatgcaa gtgagcaacc ctgaggcagg agagacagta     1260

ccgggaggac aggcccagac tggggcaagc actgagtcag gaaggcagga gtggagcagc     1320

actcacccaa ggcgctgtgt gacagaaggg cagggagaca gacagcccac agtggttggt     1380

gaggaatggg ttgatgacca ctcaagggag acagtgatcc tcaggctgga ccagggcaac     1440

ttgcatacca gtgtttcctc agcacagggc caggatgcag cccagtcaga agagaagcga     1500

ggcatcacag ctagagagct gtattcctac ttgagaagca ccaagccatg acttccccga     1560

ctccaatgtc cagtactgga agaagacagc tggagagagt ttggcttgtc ctgcatggcc     1620

aatccagtgg gtgcatccct ggacatcagc tcttcattat gcagcttccc ttttaggtct     1680

ttctcaatga gataatttct gcaaggagct ttctatcctg aactcttctt tcttacctgc     1740

tttgcggtgc agaccctctc aggagcagga agactcagag caagtcaccc ctttgtactg     1800

aattgtcctc atcttgtggg gggtttcagg actattttta tctctgacat ctctctattg     1860

ccccatctac cctaatgcat caataaaacc ttaagccact gg                        1902


<210>  2
<211>  495
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Gln Leu Leu Gln Asn Ile Asn Gly Ile Ile Glu Ala Phe Arg 
1               5                   10                  15      


Arg Tyr Ala Arg Thr Glu Gly Asn Cys Thr Ala Leu Thr Arg Gly Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu Gln Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


His Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Gln Ala Cys Phe Lys Thr Leu Ser Glu Ser Ala Glu Gly Ala 
                85                  90                  95      


Cys Gly Ser Gln Glu Ser Gly Ser Leu His Ser Gly Ala Ser Gln Glu 
            100                 105                 110         


Leu Gly Glu Gly Gln Arg Ser Gly Thr Glu Val Gly Arg Ala Gly Lys 
        115                 120                 125             


Gly Gln His Tyr Glu Gly Ser Ser His Arg Gln Ser Gln Gln Gly Ser 
    130                 135                 140                 


Arg Gly Gln Asn Arg Pro Gly Val Gln Thr Gln Gly Gln Ala Thr Gly 
145                 150                 155                 160 


Ser Ala Trp Val Ser Ser Tyr Asp Arg Gln Ala Glu Ser Gln Ser Gln 
                165                 170                 175     


Glu Arg Ile Ser Pro Gln Ile Gln Leu Ser Gly Gln Thr Glu Gln Thr 
            180                 185                 190         


Gln Lys Ala Gly Glu Gly Lys Arg Asn Gln Thr Thr Glu Met Arg Pro 
        195                 200                 205             


Glu Arg Gln Pro Gln Thr Arg Glu Gln Asp Arg Ala His Gln Thr Gly 
    210                 215                 220                 


Glu Thr Val Thr Gly Ser Gly Thr Gln Thr Gln Ala Gly Ala Thr Gln 
225                 230                 235                 240 


Thr Val Glu Gln Asp Ser Ser His Gln Thr Gly Arg Thr Ser Lys Gln 
                245                 250                 255     


Thr Gln Glu Ala Thr Asn Asp Gln Asn Arg Gly Thr Glu Thr His Gly 
            260                 265                 270         


Gln Gly Arg Ser Gln Thr Ser Gln Ala Val Thr Gly Gly His Ala Gln 
        275                 280                 285             


Ile Gln Ala Gly Thr His Thr Gln Thr Pro Thr Gln Thr Val Glu Gln 
    290                 295                 300                 


Asp Ser Ser His Gln Thr Gly Ser Thr Ser Thr Gln Thr Gln Glu Ser 
305                 310                 315                 320 


Thr Asn Gly Gln Asn Arg Gly Thr Glu Ile His Gly Gln Gly Arg Ser 
                325                 330                 335     


Gln Thr Ser Gln Ala Val Thr Gly Gly His Thr Gln Ile Gln Ala Gly 
            340                 345                 350         


Ser His Thr Glu Thr Val Glu Gln Asp Arg Ser Gln Thr Val Ser His 
        355                 360                 365             


Gly Gly Ala Arg Glu Gln Gly Gln Thr Gln Thr Gln Pro Gly Ser Gly 
    370                 375                 380                 


Gln Arg Trp Met Gln Val Ser Asn Pro Glu Ala Gly Glu Thr Val Pro 
385                 390                 395                 400 


Gly Gly Gln Ala Gln Thr Gly Ala Ser Thr Glu Ser Gly Arg Gln Glu 
                405                 410                 415     


Trp Ser Ser Thr His Pro Arg Arg Cys Val Thr Glu Gly Gln Gly Asp 
            420                 425                 430         


Arg Gln Pro Thr Val Val Gly Glu Glu Trp Val Asp Asp His Ser Arg 
        435                 440                 445             


Glu Thr Val Ile Leu Arg Leu Asp Gln Gly Asn Leu His Thr Ser Val 
    450                 455                 460                 


Ser Ser Ala Gln Gly Gln Asp Ala Ala Gln Ser Glu Glu Lys Arg Gly 
465                 470                 475                 480 


Ile Thr Ala Arg Glu Leu Tyr Ser Tyr Leu Arg Ser Thr Lys Pro 
                485                 490                 495 


<210>  3
<211>  1973
<212>  DNA
<213>  Mus musculus

<400>  3
actctacaca ctgcttaaca gaaacttgtc ccatcctgcc tgagcattag catagcttca       60

aagatgcctc agttgctgca aaacatccac gggatcatcg aagccttcgg gtgctatgcc      120

aggtcagagg gtggctgcaa agtactcacg aggcaggagt tgaagaggct cctggaacat      180

gagtttgctg acgtcatagt gaagccccat gatcctgcaa ctgtggatga agtcctgcgc      240

ctgttggatg aagataacac agggactgta gagttcaagg aattcctagt cttggtgttt      300

aaagttgcac gggcttgctt taagacactg aatgagagtc ctaagggtgc ttgcatatct      360

gacaagtctg aaggctgcta ttctggatct tcaaaagagc tggagcaaag acagagaggt      420

ggtgctgaag tggcaaaaga cggagcagca cagcactgtg aagacagcag ctgtggacag      480

agagatcagg cttctagagg acaggacagg gttgggacac atacccagaa tcaggacagc      540

taccctacac aggtcagcag tcatgacagg cagactgagt ctcagacaca ggaaatgata      600

agccaacaaa cacaagtgac aggacaggtg gagcagaccc caagaacaga agacaagagt      660

tggaccagac agaagaggtc agagaggcaa ccacagagta gccaacagac agatgagatc      720

acaactggat ctacagctca gacccaagca ggtaacttct acacacaggg gtctacctgt      780

gactataaca gaggaactaa cagccatcac caagacagaa gccatgcaga cagagcttct      840

acacaacact accagacaca ggcagggtct catactcaga tacacacaca gatggtagaa      900

caggcctggg ggcagcaaac aggaagtgat agcatccaga cacaggggtc tatctatgac      960

cagagcactg agactgtgat tcatggccaa gacaggaacc aggcaagcca gagtgttaaa     1020

gaacaccacc aggcacaggg agagtcatat attcagacac atactcagac aatggaacaa     1080

ggcaggagcc agcaggcaga aaatagtagc acccagactc atgggtccat gtatggccaa     1140

aacagagaga ctgagatcca tgggctagaa agcagtcagg cagaacaggt ggggacaaga     1200

cactaccaga cacaggcagg atcatatacc cagactttgg aacatgatgg gagccagtct     1260

gcacataaat ttgtggctca agaaaaggaa cgtacacaga caaagccatg catggggcaa     1320

agctggacac cagtaagcaa ctatgagaca gaagagtcag tgataggagg acaggtccag     1380

actgagacag acactattat agagaatcac ccaagcccga cagccaggca ggtagagaga     1440

gtacccacag tggttagaga ggagtgggtc aatgaccaca caagggaaat agtaatccga     1500

agccaggatc caggtagcct gcactctggt actccttcag ctcagggcca ggatatacca     1560

cagatggaga agaaaggaat cacagccaag ggactatata cctacttgaa gacagagcag     1620

ccatgacttt tcccgattcc agctggagtg aggttggcct gccctgccct gccctgccct     1680

gccctgccct gccctgccct gccctgccct gccatggtac ttcaccagac agccatgatt     1740

cttcttgttt ggttctttta cagtgatcat ctctacaagg tgatttcttg tcaaaactca     1800

cctctcttac ctgctgctct cagaaactca cctctcttac ctgatattct cagaaacagg     1860

aagatgtgga ggaggtcatc tcattgcact gaattccccc caattttcag ggggtttcaa     1920

agctgtttta tctctggtat ctgtccattg catcaataaa ggcttagaag ctg            1973


<210>  4
<211>  520
<212>  PRT
<213>  Mus musculus

<400>  4

Met Pro Gln Leu Leu Gln Asn Ile His Gly Ile Ile Glu Ala Phe Gly 
1               5                   10                  15      


Cys Tyr Ala Arg Ser Glu Gly Gly Cys Lys Val Leu Thr Arg Gln Glu 
            20                  25                  30          


Leu Lys Arg Leu Leu Glu His Glu Phe Ala Asp Val Ile Val Lys Pro 
        35                  40                  45              


His Asp Pro Ala Thr Val Asp Glu Val Leu Arg Leu Leu Asp Glu Asp 
    50                  55                  60                  


Asn Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
65                  70                  75                  80  


Val Ala Arg Ala Cys Phe Lys Thr Leu Asn Glu Ser Pro Lys Gly Ala 
                85                  90                  95      


Cys Ile Ser Asp Lys Ser Glu Gly Cys Tyr Ser Gly Ser Ser Lys Glu 
            100                 105                 110         


Leu Glu Gln Arg Gln Arg Gly Gly Ala Glu Val Ala Lys Asp Gly Ala 
        115                 120                 125             


Ala Gln His Cys Glu Asp Ser Ser Cys Gly Gln Arg Asp Gln Ala Ser 
    130                 135                 140                 


Arg Gly Gln Asp Arg Val Gly Thr His Thr Gln Asn Gln Asp Ser Tyr 
145                 150                 155                 160 


Pro Thr Gln Val Ser Ser His Asp Arg Gln Thr Glu Ser Gln Thr Gln 
                165                 170                 175     


Glu Met Ile Ser Gln Gln Thr Gln Val Thr Gly Gln Val Glu Gln Thr 
            180                 185                 190         


Pro Arg Thr Glu Asp Lys Ser Trp Thr Arg Gln Lys Arg Ser Glu Arg 
        195                 200                 205             


Gln Pro Gln Ser Ser Gln Gln Thr Asp Glu Ile Thr Thr Gly Ser Thr 
    210                 215                 220                 


Ala Gln Thr Gln Ala Gly Asn Phe Tyr Thr Gln Gly Ser Thr Cys Asp 
225                 230                 235                 240 


Tyr Asn Arg Gly Thr Asn Ser His His Gln Asp Arg Ser His Ala Asp 
                245                 250                 255     


Arg Ala Ser Thr Gln His Tyr Gln Thr Gln Ala Gly Ser His Thr Gln 
            260                 265                 270         


Ile His Thr Gln Met Val Glu Gln Ala Trp Gly Gln Gln Thr Gly Ser 
        275                 280                 285             


Asp Ser Ile Gln Thr Gln Gly Ser Ile Tyr Asp Gln Ser Thr Glu Thr 
    290                 295                 300                 


Val Ile His Gly Gln Asp Arg Asn Gln Ala Ser Gln Ser Val Lys Glu 
305                 310                 315                 320 


His His Gln Ala Gln Gly Glu Ser Tyr Ile Gln Thr His Thr Gln Thr 
                325                 330                 335     


Met Glu Gln Gly Arg Ser Gln Gln Ala Glu Asn Ser Ser Thr Gln Thr 
            340                 345                 350         


His Gly Ser Met Tyr Gly Gln Asn Arg Glu Thr Glu Ile His Gly Leu 
        355                 360                 365             


Glu Ser Ser Gln Ala Glu Gln Val Gly Thr Arg His Tyr Gln Thr Gln 
    370                 375                 380                 


Ala Gly Ser Tyr Thr Gln Thr Leu Glu His Asp Gly Ser Gln Ser Ala 
385                 390                 395                 400 


His Lys Phe Val Ala Gln Glu Lys Glu Arg Thr Gln Thr Lys Pro Cys 
                405                 410                 415     


Met Gly Gln Ser Trp Thr Pro Val Ser Asn Tyr Glu Thr Glu Glu Ser 
            420                 425                 430         


Val Ile Gly Gly Gln Val Gln Thr Glu Thr Asp Thr Ile Ile Glu Asn 
        435                 440                 445             


His Pro Ser Pro Thr Ala Arg Gln Val Glu Arg Val Pro Thr Val Val 
    450                 455                 460                 


Arg Glu Glu Trp Val Asn Asp His Thr Arg Glu Ile Val Ile Arg Ser 
465                 470                 475                 480 


Gln Asp Pro Gly Ser Leu His Ser Gly Thr Pro Ser Ala Gln Gly Gln 
                485                 490                 495     


Asp Ile Pro Gln Met Glu Lys Lys Gly Ile Thr Ala Lys Gly Leu Tyr 
            500                 505                 510         


Thr Tyr Leu Lys Thr Glu Gln Pro 
        515                 520 


<210>  5
<211>  2551
<212>  DNA
<213>  Rattus norvegicus

<400>  5
tgatgacact taatagctac cacttagcat aagccaagca tcagctgggt gctttttatg       60

aattatctcc taaagccttt atgatacctc tctgaagtaa gtgctagtat cagctccatt      120

cacagtgaag aaactgaggc atggacaagc aaagcaggta ggtggtggaa cccggcatta      180

aatgttgact cagaaatttc catggtctga gtgactctcc ttcccatcat aaagtacatt      240

ttgaggagaa gaacaaggaa ggtggagaaa cccaaacaca gctgaagaca caatgaaagg      300

accgggcctt ggcatactgt gtggaaacat caggggctga ctatggtgcc cataaaaagc      360

attttcatat tttccagcat agcttcaaag atgcctcagt tgctgcgaaa tatccatggg      420

atcatcgaag ccttcgggtg ctatgccagg tcagagggtg gctgcaaagt actcacgaag      480

caggagctga agaggcttct ggaatatgag tttgccgacg tcatagtgaa gccccatgat      540

cctgcaactg tggatgaagt tctgcacctg ttggatgaag ataacacagg aactgtagaa      600

ttcaaggaat tcttggtctt ggtgtttaaa gttgcccgtg cctgctttaa gacactgaat      660

gagagtccta agggtgcttg catgtctgac aagtctgaaa gctgccatgt tggatcttcc      720

aaagagctgg agcaaggaca gaggggtggt gctgaagtgg caaaggatgg agcagcacag      780

cactgtgaaa acagcagttg tggacagaga gatcaggctt ctagaggaca ggacagggtg      840

gggacacata cccagcatca ggacagctac cctacatggg tcagcagtca tgacaggcag      900

gctgagtctc agacacagga gatgataagc cagcaaacac aagtgacagg accagtggaa      960

cagaccccaa aaatagaaga caagagttgc atcggacaga agagatcaga gagacaacca     1020

cagatcagcc aacagacaga tgagatcaca actgaatcca caactcagac ccaagcaggc     1080

accttctaca cacagggatc tacctgtgat cagaacagag gaacaaacag ccttacccaa     1140

gacagaagtc agacagacca agcttctaca caacactacc agacacgggc agggtctcat     1200

actcagatac acaaccagac ggtggaacag ggctggggac agcagacagg aaaaaacaac     1260

atccaaatac agggatctat ctatgaccag agcagagaga ctgagattcg tggccaagat     1320

aggaaccagg caagccagac tgctaaagaa caccaccagg cacaggcaga gtcatatact     1380

cgggcgcaca ctcagacaat ggaacaaggc aggagccagc aggaagaaaa tggcagtatc     1440

cagactcatg cttccatctg tggccaaaac agaggaacca agatccatga gcaagaaagc     1500

aatcaggtag aacaggtggg aacaggacac tgccagacac aggcaggatc agatgcccag     1560

actttggagc ataatgggag ccattctgca cgacaagtag tggctcaaga aaagggacaa     1620

atgcagacac agtcatgcat ggggcaaagc tggacaccag tgagcaacta tgagacagga     1680

gagccagtgc taggacaggt ccagactgag atagacactg ttaaagaaag acaaccgtgg     1740

aacagcaatc acccaagtct ggcaggaagg cagggagaaa gaagccccac agtggttaga     1800

gaggagtggg tcaatgacca cacaagagaa atagtgatcc gaagccagga tccaggcagc     1860

ctgcactctg gtgctccttc agctcagggc caggatacag cacagatgga gaagaaagga     1920

atcacagcca agggattata ttcgtacctg aagacagagc agccatgact tctcctgact     1980

ccagtgccca taccaaaaga cagctgcagt gaggttggcc tgccttgtcc tgtgctgccc     2040

tgtcacagca cttcactgga cagctatgat tcttctcatt tggttctttt tcagcaatca     2100

tttctacaag gtgatttctt gtctaaactt acctctcttg cccggtgctc tcagaaactc     2160

acctctctta tctgctactc tcaggaacag gaagccatgg aggaggtcat ctcattgcac     2220

tgaatttctt ccaactttca gggggtttca aagctgtttt atctctgcta tcggtccatt     2280

gcatcaataa aggcttagca gctggtttca gtgtgttatt caatagtttc tactgatgtg     2340

acaaactgag agctctagag ttctgatgtt gaactgaaca tagcctcatc tctcaaggaa     2400

gactgagtta gaacgagcta aatagaggag agagcacact gtatacttgg cagagatggg     2460

tcagggatgt cttcttccat aaagatgctt atttgtagta gccctcaaaa ggacaactaa     2520

gagaaacaga gatataatta ctatcattca g                                    2551


<210>  6
<211>  541
<212>  PRT
<213>  Rattus norvegicus

<400>  6

Met Val Pro Ile Lys Ser Ile Phe Ile Phe Ser Ser Ile Ala Ser Lys 
1               5                   10                  15      


Met Pro Gln Leu Leu Arg Asn Ile His Gly Ile Ile Glu Ala Phe Gly 
            20                  25                  30          


Cys Tyr Ala Arg Ser Glu Gly Gly Cys Lys Val Leu Thr Lys Gln Glu 
        35                  40                  45              


Leu Lys Arg Leu Leu Glu Tyr Glu Phe Ala Asp Val Ile Val Lys Pro 
    50                  55                  60                  


His Asp Pro Ala Thr Val Asp Glu Val Leu His Leu Leu Asp Glu Asp 
65                  70                  75                  80  


Asn Thr Gly Thr Val Glu Phe Lys Glu Phe Leu Val Leu Val Phe Lys 
                85                  90                  95      


Val Ala Arg Ala Cys Phe Lys Thr Leu Asn Glu Ser Pro Lys Gly Ala 
            100                 105                 110         


Cys Met Ser Asp Lys Ser Glu Ser Cys His Val Gly Ser Ser Lys Glu 
        115                 120                 125             


Leu Glu Gln Gly Gln Arg Gly Gly Ala Glu Val Ala Lys Asp Gly Ala 
    130                 135                 140                 


Ala Gln His Cys Glu Asn Ser Ser Cys Gly Gln Arg Asp Gln Ala Ser 
145                 150                 155                 160 


Arg Gly Gln Asp Arg Val Gly Thr His Thr Gln His Gln Asp Ser Tyr 
                165                 170                 175     


Pro Thr Trp Val Ser Ser His Asp Arg Gln Ala Glu Ser Gln Thr Gln 
            180                 185                 190         


Glu Met Ile Ser Gln Gln Thr Gln Val Thr Gly Pro Val Glu Gln Thr 
        195                 200                 205             


Pro Lys Ile Glu Asp Lys Ser Cys Ile Gly Gln Lys Arg Ser Glu Arg 
    210                 215                 220                 


Gln Pro Gln Ile Ser Gln Gln Thr Asp Glu Ile Thr Thr Glu Ser Thr 
225                 230                 235                 240 


Thr Gln Thr Gln Ala Gly Thr Phe Tyr Thr Gln Gly Ser Thr Cys Asp 
                245                 250                 255     


Gln Asn Arg Gly Thr Asn Ser Leu Thr Gln Asp Arg Ser Gln Thr Asp 
            260                 265                 270         


Gln Ala Ser Thr Gln His Tyr Gln Thr Arg Ala Gly Ser His Thr Gln 
        275                 280                 285             


Ile His Asn Gln Thr Val Glu Gln Gly Trp Gly Gln Gln Thr Gly Lys 
    290                 295                 300                 


Asn Asn Ile Gln Ile Gln Gly Ser Ile Tyr Asp Gln Ser Arg Glu Thr 
305                 310                 315                 320 


Glu Ile Arg Gly Gln Asp Arg Asn Gln Ala Ser Gln Thr Ala Lys Glu 
                325                 330                 335     


His His Gln Ala Gln Ala Glu Ser Tyr Thr Arg Ala His Thr Gln Thr 
            340                 345                 350         


Met Glu Gln Gly Arg Ser Gln Gln Glu Glu Asn Gly Ser Ile Gln Thr 
        355                 360                 365             


His Ala Ser Ile Cys Gly Gln Asn Arg Gly Thr Lys Ile His Glu Gln 
    370                 375                 380                 


Glu Ser Asn Gln Val Glu Gln Val Gly Thr Gly His Cys Gln Thr Gln 
385                 390                 395                 400 


Ala Gly Ser Asp Ala Gln Thr Leu Glu His Asn Gly Ser His Ser Ala 
                405                 410                 415     


Arg Gln Val Val Ala Gln Glu Lys Gly Gln Met Gln Thr Gln Ser Cys 
            420                 425                 430         


Met Gly Gln Ser Trp Thr Pro Val Ser Asn Tyr Glu Thr Gly Glu Pro 
        435                 440                 445             


Val Leu Gly Gln Val Gln Thr Glu Ile Asp Thr Val Lys Glu Arg Gln 
    450                 455                 460                 


Pro Trp Asn Ser Asn His Pro Ser Leu Ala Gly Arg Gln Gly Glu Arg 
465                 470                 475                 480 


Ser Pro Thr Val Val Arg Glu Glu Trp Val Asn Asp His Thr Arg Glu 
                485                 490                 495     


Ile Val Ile Arg Ser Gln Asp Pro Gly Ser Leu His Ser Gly Ala Pro 
            500                 505                 510         


Ser Ala Gln Gly Gln Asp Thr Ala Gln Met Glu Lys Lys Gly Ile Thr 
        515                 520                 525             


Ala Lys Gly Leu Tyr Ser Tyr Leu Lys Thr Glu Gln Pro 
    530                 535                 540     


