                         SEQUENCE LISTING

<110>  ALBERT EINSTEIN COLLEGE OF MEDICINE
 
<120>  KIR3DL3 IS AN INHIBITORY RECEPTOR OF THE IMMUNE SYSTEM AND USES 
       THEREOF

<130>  129807.8002.WO00

<150>  US 62/911,169
<151>  2019-10-04

<160>  342   

<170>  PatentIn version 3.5

<210>  1
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: DNA sequence

<400>  1
atgaactttg ggttgagatt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgatgctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtacc tatgccatgt cttgggttcg ccagactccg      180

gagaagaggc tggagtgggt cgcaaccatt cttagtggtg gtaattacac ctactatcca      240

gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagaacac cctgaacctg      300

caaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgtaat cccctatggt      360

agtagtcctt ttgactattg gggccaaggc accactctca cagtctctct a               411


<210>  2
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH DNA sequence:

CDR1

<400>  2
ggattcactt tcagtaccta tgccatgtct                                        30


<210>  3
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH DNA sequence:

CDR2

<400>  3
attcttagtg gtggtaatta cacctactat ccagacagtg tgaagggg                    48


<210>  4
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH DNA sequence:

CDR3

<400>  4
gtaatcccct atggtagtag tccttttgac tat                                    33


<210>  5
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  5

Met Asn Phe Gly Leu Arg Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Thr Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Leu Ser Gly Gly Asn Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Asn Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Val Ile Pro Tyr Gly Ser Ser Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser 
    130                 135     


<210>  6
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

FR1

<400>  6

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  7
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

CDR1

<400>  7

Gly Phe Thr Phe Ser Thr Tyr Ala Met Ser 
1               5                   10  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acids sequence:

FR2

<400>  8

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

CDR2

<400>  9

Thr Ile Leu Ser Gly Gly Asn Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

FR3

<400>  10

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Asn Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
            20                  25                  30  


<210>  11
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

CDR3

<400>  11

Val Ile Pro Tyr Gly Ser Ser Pro Phe Asp Tyr 
1               5                   10      


<210>  12
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 heavy chain VH: Amino acid sequence:

FR4

<400>  12

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
1               5                   10  


<210>  13
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  13
ttattactag tcgacacggg catcaagatg aagtcacaga cccaggtctt cgtatttcta       60

ctgctctgtg tgtctggtgc tcatgggagt attgtgatga cccagactcc caaattcctg      120

cttgtatcag caggagacag ggttaccata acctgcaagg ccagtcagag tgtgagtaat      180

gatgtagctt ggtaccaaca gaagccaggg cagtctccta aactgctgat atactatgca      240

tccaatcgct acactggagt ccctgatcgc ttcactggca gtggatatgg gacggatttc      300

actttcacca tcagcactgt gcaggctgaa gacctggcag tttatttctg tcagcaggat      360

tatagctctc cgtggacgtt cggtggaggc accaagctgg aaatcaaacg ggctgatgct      420

gca                                                                    423


<210>  14
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: DNA sequence:

CDR1

<400>  14
aaggccagtc agagtgtgag taatgat                                           27


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: DNA sequence:

CDR2

<400>  15
tatgcatcca atcgctacac t                                                 21


<210>  16
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: DNA sequence:

CDR3

<400>  16
cagcaggatt atagctctcc gtggacg                                           27


<210>  17
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  17

Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu 
            20                  25                  30          


Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125         


<210>  18
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

FR1

<400>  18

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

CDR1

<400>  19

Lys Ala Ser Gln Ser Val Ser Asn Asp 
1               5                   


<210>  20
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

FR2

<400>  20

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  21
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

CDR2

<400>  21

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  22
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

FR3

<400>  22

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  23
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

CDR3

<400>  23

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  8G7 light chain VL: Amino acid sequence:

FR4

<400>  24

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  25
<211>  431
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  25
tggggaattc atggaatgga gctgggtttt tctcttcctc ctgtcaataa ctacaggtgt       60

ccactcccag gcttatctac agcagtctgg ggctgagctg gtgaggtctg gggcctcagt      120

gaagatgtcc tgcaaggctt ctggctacac atttaccagt tacaatatac actgggtaaa      180

gcagacacct ggacagggcc tggaatggat tggatatatt tatcctggag atggtgttac      240

taactacaat cagaagttca agggcaaggc cacattgact gcagacacat cctccagcac      300

agcctacatg cagatcagca gcctgacatc tgaagactct gcggtctatt tctgtgcaag      360

atcgggcaac tatggtaact acgaagggtt tgcttactgg ggccaaggga ctctggtcac      420

tgtctctgct a                                                           431


<210>  26
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: DNA sequence:

CDR1

<400>  26
ggctacacat ttaccagtta caatatacac                                        30


<210>  27
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: DNA sequence:

CDR2

<400>  27
tatatttatc ctggagatgg tgttactaac tacaatcaga agttcaaggg c                51


<210>  28
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: DNA sequence:

CDR3

<400>  28
atcgggcaac tatggtaact acgaagggtt tgcttac                                37


<210>  29
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  29

Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Ile Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Ser Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Tyr Pro Gly Asp Gly Val Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

FR1

<400>  30

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

CDR1

<400>  31

Gly Tyr Thr Phe Thr Ser Tyr Asn Ile His 
1               5                   10  


<210>  32
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

FR2

<400>  32

Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

CDR2

<400>  33

Tyr Ile Tyr Pro Gly Asp Gly Val Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

FR3

<400>  34

Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  35
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

CDR3

<400>  35

Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala Tyr 
1               5                   10          


<210>  36
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 heavy chain VH: Amino acid sequence:

FR4

<400>  36

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  37
<211>  296
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: DNA sequence:

       FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  37
ttccatgtat gcatctctag gagagagagt cactatcact tgcaaggcga gtcaggacac       60

taatagctat ttaagctggt tccagcagaa accagggaaa tctcctaaga ccctgatcta      120

tcgtgcaaac agattggtag atggggtccc atcaaggttc agtggcagtg gatctgggca      180

agattattct ctcaccatca gcagcctgga gtatgaagat atgggaattt attattgtct      240

acagtatgat gagtttccgt acacgttcgg aggggggacc aagctggaaa taaaac          296


<210>  38
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: DNA sequence:

CDR1

<400>  38
aaggcgagtc aggacactaa tagctattta agc                                    33


<210>  39
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: DNA sequence:

CDR2

<400>  39
cgtgcaaaca gattggtaga t                                                 21


<210>  40
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: DNA sequence:

CDR3

<400>  40
ctacagtatg atgagtttcc gtacacg                                           27


<210>  41
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

       FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  41

Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala 
1               5                   10                  15      


Ser Gln Asp Thr Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly 
            20                  25                  30          


Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly 
        35                  40                  45              


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu 
    50                  55                  60                  


Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu 
65                  70                  75                  80  


Gln Tyr Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                85                  90                  95      


Ile Lys 
        


<210>  42
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

FR1

<400>  42

Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys 
1               5                   10                  


<210>  43
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

CDR1

<400>  43

Lys Ala Ser Gln Asp Thr Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

FR2

<400>  44

Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr 
1               5                   10                  15  


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

CDR2

<400>  45

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  46
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

FR3

<400>  46

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

CDR3

<400>  47

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E10 light chain VL: Amino acid sequence:

FR4

<400>  48

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  49
<211>  264
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: DNA sequence:

FR2-CDR2-FR3-CDR3-FR4

<400>  49
gcgctgggta aagcagacac ctggacaggg cctggaatgg attggatata tttatcctgg       60

agatggtggt actaactgca atcagaagtt ccagggcaag gccacattga ctgcagacac      120

atcctccagc acagcctaca tgcagatcag cagcctgaca tctgaagact ctgcggtcta      180

tttctgtgca agatcgggca actatggtaa ctacgaaggg tttgctttct ggggccaagg      240

gactctggtc actgtctctg cagc                                             264


<210>  50
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: DNA sequence:

CDR2

<400>  50
tatatttatc ctggagatgg tggtactaac tgcaatcaga agttccaggg c                51


<210>  51
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: DNA sequence:

CDR3

<400>  51
tcgggcaact atggtaacta cgaagggttt gctttc                                 36


<210>  52
<211>  87
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acid sequence:

FR2-CDR2-FR3-CDR3-FR4

<400>  52

Arg Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly Tyr 
1               5                   10                  15      


Ile Tyr Pro Gly Asp Gly Gly Thr Asn Cys Asn Gln Lys Phe Gln Gly 
            20                  25                  30          


Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
        35                  40                  45              


Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
    50                  55                  60                  


Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala Phe Trp Gly Gln Gly 
65                  70                  75                  80  


Thr Leu Val Thr Val Ser Ala 
                85          


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acids sequence:

FR2

<400>  53

Arg Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15  


<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acid sequence:

CDR2

<400>  54

Tyr Ile Tyr Pro Gly Asp Gly Gly Thr Asn Cys Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acid sequence:

FR3

<400>  55

Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys Ala Arg 
            20                  25                  30          


<210>  56
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acid sequence:

CDR3

<400>  56

Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala Phe 
1               5                   10          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 heavy chain VH: Amino acid sequence:

FR4

<400>  57

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  58
<211>  394
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  58
atgagggccc ctgctcagtt ttttgggatc ttgttgctct ggtttccagg tatcaaatgt       60

gacatcaaga tgacccagtc tccatcctcc atgtatgcat ctctaggaga gagagtcact      120

atcacttgca aggcgagtca ggacactaat agctatttaa gctggttcca gcagaaacca      180

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      240

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagccg cctggagtat      300

gaagatatgg gaatttatta ttgtctacag tataatgagt ttccgtacac gttcggaggg      360

gggaccaagc tggaaataaa acgggctgat gctg                                  394


<210>  59
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: DNA sequence:

CDR1

<400>  59
aaggcgagtc aggacactaa tagctattta agc                                    33


<210>  60
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: DNA sequence:

CDR2

<400>  60
cgtgcaaaca gattggtaga t                                                 21


<210>  61
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: DNA sequence:

CDR3

<400>  61
ctacagtata atgagtttcc gtacacg                                           27


<210>  62
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  62

Met Arg Ala Pro Ala Gln Phe Phe Gly Ile Leu Leu Leu Trp Phe Pro 
1               5                   10                  15      


Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr 
            20                  25                  30          


Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp 
        35                  40                  45              


Thr Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro 
    50                  55                  60                  


Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Arg Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asn 
            100                 105                 110         


Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala 
    130     


<210>  63
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

FR1

<400>  63

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys 
            20              


<210>  64
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

CDR1

<400>  64

Lys Ala Ser Gln Asp Thr Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

FR2

<400>  65

Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr 
1               5                   10                  15  


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

CDR2

<400>  66

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  67
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain VL: Amino acid sequence:

FR3

<400>  67

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Arg Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  68
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

CDR3

<400>  68

Leu Gln Tyr Asn Glu Phe Pro Tyr Thr 
1               5                   


<210>  69
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  26E2 light chain VL: Amino acid sequence:

FR4

<400>  69

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
1               5                   10                  


<210>  70
<211>  435
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  70
tgtggggaat tccatggaat ggagctgggt ttttctcttc ctcctgtcaa taactacagg       60

tgtccactcc caggcttatc tacagcagtc tggggctgag ctggtgaggt ctggggcctc      120

agtgaagatg tcctgcaagg cttctggcta cacatttacc agttacaata tgcactgggt      180

aaagcagaca cctggacagg gcctggaatg gattggatat atttttcctg gagatggtgg      240

tactaactac aatcagaagt tcaagggcaa ggccacattg actgcagaca catcctccag      300

cacagcctac atgcagatca gcagcctgac atctgaagac tctgcggtct atttctgtgc      360

aagatcgggc aactatggta actacgaagg gtttgcttac tggggccaag ggactctggt      420

cactgtctct gctag                                                       435


<210>  71
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: DNA sequence:

CDR1

<400>  71
ggctacacat ttaccagtta caatatgcac                                        30


<210>  72
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: DNA sequence:

CDR2

<400>  72
tatatttttc ctggagatgg tggtactaac tacaatcaga agttcaaggg c                51


<210>  73
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: DNA sequence:

CDR3

<400>  73
gcaagatcgg gcaactatgg taactacgaa gggtttgctt ac                          42


<210>  74
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  74

Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Ile Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Ser Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Phe Pro Gly Asp Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 


<210>  75
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

FR1

<400>  75

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  76
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

CDR1

<400>  76

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  77
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

FR2

<400>  77

Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  78
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

CDR2

<400>  78

Tyr Ile Phe Pro Gly Asp Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  79
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

FR3

<400>  79

Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
            20                  25                  30  


<210>  80
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

CDR3

<400>  80

Ala Arg Ser Gly Asn Tyr Gly Asn Tyr Glu Gly Phe Ala Tyr 
1               5                   10                  


<210>  81
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 heavy chain VH: Amino acid sequence:

FR4

<400>  81

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  82
<211>  407
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  82
tactagtcga catgaggccc cctgctcagt tttttgggat cttgttgctc tggtttccag       60

gtatcaaatg tgacatcaag atgacccagt ctccatcttc catgtatgca tctctaggag      120

agagagtcac tatcacttgc aaggcgagtc aggacattaa tagctattta agctggttcc      180

agcagaaacc agggaaatct cctaagaccc tgatctatcg tgcaaacaga ttggtagatg      240

gggtcccatc aaggttcagt ggcagtggat ctgggcaaga ttattctctc accatcagca      300

gcctggagta tgaagatatg ggaatttatt attgtctaca gtatgatgaa tttccgtaca      360

cgttcggagg ggggaccaag ctggaaataa aacgggctga tgctgca                    407


<210>  83
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: DNA sequence:

CDR1

<400>  83
aaggcgagtc aggacattaa tagctattta agc                                    33


<210>  84
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: DNA sequence:

CDR2

<400>  84
cgtgcaaaca gattggtaga tg                                                22


<210>  85
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: DNA sequence:

CDR3

<400>  85
ctacagtatg atgaatttcc gtacacg                                           27


<210>  86
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  86

Leu Val Asp Met Arg Pro Pro Ala Gln Phe Phe Gly Ile Leu Leu Leu 
1               5                   10                  15      


Trp Phe Pro Gly Ile Lys Cys Asp Ile Lys Met Thr Gln Ser Pro Ser 
            20                  25                  30          


Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala 
        35                  40                  45              


Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly 
    50                  55                  60                  


Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly 
65                  70                  75                  80  


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu 
                85                  90                  95      


Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu 
            100                 105                 110         


Gln Tyr Asp Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Arg Ala Asp Ala Ala 
    130                 135 


<210>  87
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

FR1

<400>  87

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys 
            20              


<210>  88
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

CDR1

<400>  88

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  89
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

FR2

<400>  89

Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr 
1               5                   10                  15  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

CDR2

<400>  90

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  91
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

FR3

<400>  91

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  92
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

CDR3

<400>  92

Leu Gln Tyr Asp Glu Phe Pro Tyr Thr 
1               5                   


<210>  93
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  31C4 light chain VL: Amino acid sequence:

FR4

<400>  93

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
1               5                   10                  15  


<210>  94
<211>  430
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  94
tggggaattc atggagttgg ggttcagctg gattttcctt ggaacacttt taaatggtat       60

ccagtgtgag gtgaagctgg tggagtctgg aggagtcttg gtacagcctg ggggttctct      120

gagactctcc tgtgcaactt ctggattcac cttcactgat tactacatgg gctgggtccg      180

ccagcctcca ggaaaggcgc ttgagtggtt gggttttatt agaaacaaag ctaatggtta      240

cacaacagag tccagtgcat ctgtgaaggg tcggttcacc atctccagag ataattccca      300

aagcatcctc tatcttcaaa tgaacaccct gagagctgag gacagtgcca cttattactg      360

tgcaagagat tactactccg gtagtagcct tgactactgg ggccaaggca ccactctcac      420

agtctcctca                                                             430


<210>  95
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: DNA sequence:

CDR1

<400>  95
ggattcacct tcactgatta ctacatgggc                                        30


<210>  96
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: DNA sequence:

CDR2

<400>  96
tttattagaa acaaagctaa tggttacaca acagagtcca gtgcatctgt gaagggt          57


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: DNA sequence:

CDR3

<400>  97
gattactact ccggtagtag ccttgactac                                        30


<210>  98
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acids sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  98

Met Glu Leu Gly Phe Ser Trp Ile Phe Leu Gly Thr Leu Leu Asn Gly 
1               5                   10                  15      


Ile Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Thr Asp Tyr Tyr Met Gly Trp Val Arg Gln Pro Pro Gly Lys Ala Leu 
    50                  55                  60                  


Glu Trp Leu Gly Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu 
65                  70                  75                  80  


Ser Ser Ala Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
                85                  90                  95      


Gln Ser Ile Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Ser 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ala Arg Asp Tyr Tyr Ser Gly Ser Ser Leu Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
    130                 135                 140 


<210>  99
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acids sequence:

FR1

<400>  99

Glu Val Lys Leu Val Glu Ser Gly Gly Val Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser 
            20                  25  


<210>  100
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

CDR1

<400>  100

Gly Phe Thr Phe Thr Asp Tyr Tyr Met Gly 
1               5                   10  


<210>  101
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

FR2

<400>  101

Trp Val Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Gly 
1               5                   10                  


<210>  102
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

CDR2

<400>  102

Phe Ile Arg Asn Lys Ala Asn Gly Tyr Thr Thr Glu Ser Ser Ala Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  103
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

FR3

<400>  103

Arg Phe Thr Ile Ser Arg Asp Asn Ser Gln Ser Ile Leu Tyr Leu Gln 
1               5                   10                  15      


Met Asn Thr Leu Arg Ala Glu Asp Ser Ala Thr Tyr Tyr Cys Ala Arg 
            20                  25                  30          


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

CDR3

<400>  104

Asp Tyr Tyr Ser Gly Ser Ser Leu Asp Tyr 
1               5                   10  


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 heavy chain VH: Amino acid sequence:

FR4

<400>  105

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  106
<211>  406
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  106
tctatactag tcgacaggag gaccccggct cagatttgtg gtctcctgtt gctctttttt       60

caaggtacca gatgtgatat ccagatgaca cagactacat cctccctgtc tgcctctctg      120

ggagacagag tcaccatcag ttgcagggca agtcaggaca ttagcaatta tttaaattgg      180

tatcagcaga aaccagatgg aactgttaaa ctcctgatct actacacatc aagattacac      240

tcaggagtcc catcaaggtt cagtggcagt gggtctggaa cagattattc tctctccatt      300

agcaacctgg agcaagaaga tattgccact tacttttgcc aacagggtta tacgcttccg      360

tacacgttcg gaggggggac caagcttgaa ataaaacggg ctgatg                     406


<210>  107
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: DNA sequence:

CDR1

<400>  107
agggcaagtc aggacattag caattattta aat                                    33


<210>  108
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: DNA sequence:

CDR2

<400>  108
tacacatcaa gattacactc a                                                 21


<210>  109
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: DNA sequence:

CDR3

<400>  109
caacagggtt atacgcttcc gtacacg                                           27


<210>  110
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  110

Ser Ile Leu Val Asp Arg Arg Thr Pro Ala Gln Ile Cys Gly Leu Leu 
1               5                   10                  15      


Leu Leu Phe Phe Gln Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr 
            20                  25                  30          


Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys 
        35                  40                  45              


Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys 
    50                  55                  60                  


Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Tyr Thr Ser Arg Leu His 
65                  70                  75                  80  


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr 
                85                  90                  95      


Ser Leu Ser Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe 
            100                 105                 110         


Cys Gln Gln Gly Tyr Thr Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Ala Asp 
    130                 135 


<210>  111
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

FR1

<400>  111

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys 
            20              


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

CDR1

<400>  112

Arg Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  113
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

FR2

<400>  113

Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  114
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

CDR2

<400>  114

Tyr Thr Ser Arg Leu His Ser 
1               5           


<210>  115
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

FR3

<400>  115

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser 
1               5                   10                  15      


Leu Ser Ile Ser Asn Leu Glu Gln Glu Asp Ile Ala Thr Tyr Phe Cys 
            20                  25                  30          


<210>  116
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

CDR3

<400>  116

Gln Gln Gly Tyr Thr Leu Pro Tyr Thr 
1               5                   


<210>  117
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  34B10 light chain VL: Amino acid sequence:

FR4

<400>  117

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp 
1               5                   10              


<210>  118
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  118
atgtacttgg gactgagctg tgtatttctt gtggctcttt tgaatggtgt ccagtgtcag       60

gtgcagcttg tagagaccgg gggaggcttg gtgaggcctg gaaattctct gaaactctcc      120

tgtgttacct cgggattcac tttcagtaac taccggatgc actggcttcg ccagcctcca      180

gggaagaggc tggagtggat tgctgtaatt acagtcaaat ctgataatta tggagcaaat      240

tttgcagagt ctgtgaaagg cagattcact atttcaagag atgattcaaa aagcagtgtc      300

tacctgcaga tgaacagatt aagagaggaa gacactgcca cttattattg tagtagaggt      360

agtggcccag ggtttgctta ctggggccaa gggactctgg tcactgtctc t               411


<210>  119
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: DNA sequence:

CDR1

<400>  119
ggattcactt tcagtaacta ccggatgcac                                        30


<210>  120
<211>  57
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: DNA sequence:

CDR2

<400>  120
gtaattacag tcaaatctga taattatgga gcaaattttg cagagtctgt gaaaggc          57


<210>  121
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: DNA sequence:

CDR3

<400>  121
agtagaggta gtggcccagg gtttgcttac                                        30


<210>  122
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  122

Met Tyr Leu Gly Leu Ser Cys Val Phe Leu Val Ala Leu Leu Asn Gly 
1               5                   10                  15      


Val Gln Cys Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Arg 
            20                  25                  30          


Pro Gly Asn Ser Leu Lys Leu Ser Cys Val Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Arg Met His Trp Leu Arg Gln Pro Pro Gly Lys Arg Leu 
    50                  55                  60                  


Glu Trp Ile Ala Val Ile Thr Val Lys Ser Asp Asn Tyr Gly Ala Asn 
65                  70                  75                  80  


Phe Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser 
                85                  90                  95      


Lys Ser Ser Val Tyr Leu Gln Met Asn Arg Leu Arg Glu Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Tyr Cys Ser Arg Gly Ser Gly Pro Gly Phe Ala Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser 
    130                 135         


<210>  123
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acids sequence:

FR1

<400>  123

Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Val Arg Pro Gly Asn 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Thr Ser 
            20                  25  


<210>  124
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

CDR1

<400>  124

Gly Phe Thr Phe Ser Asn Tyr Arg Met His 
1               5                   10  


<210>  125
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

FR2

<400>  125

Trp Leu Arg Gln Pro Pro Gly Lys Arg Leu Glu Trp Ile Ala 
1               5                   10                  


<210>  126
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

CDR2

<400>  126

Val Ile Thr Val Lys Ser Asp Asn Tyr Gly Ala Asn Phe Ala Glu Ser 
1               5                   10                  15      


Val Lys Gly 
            


<210>  127
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

FR3

<400>  127

Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser Val Tyr Leu Gln 
1               5                   10                  15      


Met Asn Arg Leu Arg Glu Glu Asp Thr Ala Thr Tyr Tyr Cys 
            20                  25                  30  


<210>  128
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

CDR3

<400>  128

Ser Arg Gly Ser Gly Pro Gly Phe Ala Tyr 
1               5                   10  


<210>  129
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 heavy chain VH: Amino acid sequence:

FR4

<400>  129

Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
1               5                   10  


<210>  130
<211>  411
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  130
atgggcttca agatggagtc acagactcag gtcctcatct ccttgctgtt ctgggtatct       60

ggtacctgtg gggacattgt gatgacacag tctccatcct ccctgagtgt gtcagcagga      120

gagaaggtca ctatgagctg caagtccagt cagagtctgt taaacagtgg aaatcaaaag      180

aactacttgg cctggtacca gcagaaacca gggcagcctc ctaaactgtt gatctacggg      240

gcatccacta gggaatctgg ggtccctgat cgcttcacag gcagtggatc tggaaccgat      300

ttcactctta ccatcagcag tgtgcaggct gaagacctgg cagtttatta ctgtcagaat      360

gatcatagtt atccattcac gttcggctcg gggacaaagt tggaaataaa a               411


<210>  131
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: DNA sequence:

CDR1

<400>  131
aagtccagtc agagtctgtt aaacagtgga aatcaaaaga actacttggc c                51


<210>  132
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: DNA sequence:

CDR2

<400>  132
ggggcatcca ctagggaatc t                                                 21


<210>  133
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: DNA sequence:

CDR3

<400>  133
cagaatgatc atagttatcc attcacg                                           27


<210>  134
<211>  137
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  134

Met Gly Phe Lys Met Glu Ser Gln Thr Gln Val Leu Ile Ser Leu Leu 
1               5                   10                  15      


Phe Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Thr Gln Ser Pro 
            20                  25                  30          


Ser Ser Leu Ser Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys 
        35                  40                  45              


Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu Ala 
    50                  55                  60                  


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Gly 
65                  70                  75                  80  


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly 
                85                  90                  95      


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp 
            100                 105                 110         


Leu Ala Val Tyr Tyr Cys Gln Asn Asp His Ser Tyr Pro Phe Thr Phe 
        115                 120                 125             


Gly Ser Gly Thr Lys Leu Glu Ile Lys 
    130                 135         


<210>  135
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

FR1

<400>  135

Asp Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys 
            20              


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

CDR1

<400>  136

Lys Ser Ser Gln Ser Leu Leu Asn Ser Gly Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      


Ala 
    


<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

FR2

<400>  137

Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  138
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

CDR2

<400>  138

Gly Ala Ser Thr Arg Glu Ser 
1               5           


<210>  139
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

FR3

<400>  139

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys 
            20                  25                  30          


<210>  140
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

CDR3

<400>  140

Gln Asn Asp His Ser Tyr Pro Phe Thr 
1               5                   


<210>  141
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  37A3 light chain VL: Amino acid sequence:

FR4

<400>  141

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  142
<211>  432
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  142
tggggaattc catggaatgg agctgggttt ttctcttcct cctgtcaata actacaggtg       60

tccactccca ggcttatcta cagcagtctg gggctgagct ggtgaggtct ggggcctcag      120

tgaagatgtc ctgcaaggct tctggctaca catttaccag ttacaatatg cactgggtaa      180

agcagacacc tggacagggc ctggaatgga ttggatatat ttttcctgga gatggtggta      240

ctaactacaa tcagaagttc aagggcaagg ccacattgac tgcagacaca tcctccagca      300

cagcctacat gcagatcagc agcctgacat ctgaagactc tgcggtctat ttctgtgcaa      360

gatcgggcta ctatggtaac tacgaagggt ttgcttactg gggccaaggg actctggtca      420

ctgtctctgc ag                                                          432


<210>  143
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: DNA sequence:

CDR1

<400>  143
ggctacacat ttaccagtta caatatgcac                                        30


<210>  144
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: DNA sequence:

CDR2

<400>  144
tatatttttc ctggagatgg tggtactaac tacaatcaga agttcaaggg c                51


<210>  145
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: DNA sequence:

CDR3

<400>  145
gcaagatcgg gctactatgg taactacgaa gggtttgctt ac                          42


<210>  146
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  146

Met Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Ile Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Ser Gly Ala Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Asn Met His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Tyr Ile Phe Pro Gly Asp Gly Gly Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Ser Gly Tyr Tyr Gly Asn Tyr Glu Gly Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140 


<210>  147
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acids sequence:

FR1

<400>  147

Gln Ala Tyr Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Ser Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser 
            20                  25  


<210>  148
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

CDR1

<400>  148

Gly Tyr Thr Phe Thr Ser Tyr Asn Met His 
1               5                   10  


<210>  149
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

FR2

<400>  149

Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  150
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

CDR2

<400>  150

Tyr Ile Phe Pro Gly Asp Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  151
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

FR3

<400>  151

Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser Thr Ala Tyr Met Gln 
1               5                   10                  15      


Ile Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
            20                  25                  30  


<210>  152
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

CDR3

<400>  152

Ala Arg Ser Gly Tyr Tyr Gly Asn Tyr Glu Gly Phe Ala Tyr 
1               5                   10                  


<210>  153
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 heavy chain VH: Amino acid sequence:

FR4

<400>  153

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  154
<211>  303
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  154
cttccatgta tgcatctcta ggagagagag tcactatcac ttgcaaggcg agtcaggaca       60

ttaatagcta tttaagctgg ttccagcaga aaccagggaa atctcctaag accctgatct      120

atcgtgcaaa cagattggta gatggggtcc catcaaggtt cagtggcagt ggatctgggc      180

aagattattc tctcaccatc agcagcctgg aatatgaaga tatgggaatt tattattgtc      240

tacattatgc tgagtttccg tacacgttcg gaggggggac caagctggaa ataaaacggg      300

ctg                                                                    303


<210>  155
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: DNA sequence:

CDR1

<400>  155
aaggcgagtc aggacattaa tagctattta agc                                    33


<210>  156
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: DNA sequence:

CDR2

<400>  156
cgtgcaaaca gattggtaga t                                                 21


<210>  157
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: DNA sequence:

CDR3

<400>  157
ctacattatg ctgagtttcc gtacacg                                           27


<210>  158
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

       FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  158

Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys Lys Ala 
1               5                   10                  15      


Ser Gln Asp Ile Asn Ser Tyr Leu Ser Trp Phe Gln Gln Lys Pro Gly 
            20                  25                  30          


Lys Ser Pro Lys Thr Leu Ile Tyr Arg Ala Asn Arg Leu Val Asp Gly 
        35                  40                  45              


Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser Leu 
    50                  55                  60                  


Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys Leu 
65                  70                  75                  80  


His Tyr Ala Glu Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu 
                85                  90                  95      


Ile Lys Arg Ala 
            100 


<210>  159
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

FR1

<400>  159

Ser Met Tyr Ala Ser Leu Gly Glu Arg Val Thr Ile Thr Cys 
1               5                   10                  


<210>  160
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

CDR1

<400>  160

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

FR2

<400>  161

Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile Tyr 
1               5                   10                  15  


<210>  162
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

CDR2

<400>  162

Arg Ala Asn Arg Leu Val Asp 
1               5           


<210>  163
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

FR3

<400>  163

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Gln Asp Tyr Ser 
1               5                   10                  15      


Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  164
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

CDR3

<400>  164

Leu His Tyr Ala Glu Phe Pro Tyr Thr 
1               5                   


<210>  165
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  12A10 light chain VL: Amino acid sequence:

FR4

<400>  165

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
1               5                   10          


<210>  166
<211>  434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  166
tactagtcga catgggatgg agctgtatca tgttctttct ggtagcaaca gctacaggtg       60

tgcactccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct ggggtctcag      120

tgaagatttc ctgcaagggt tccggctaca cattcagtga ttatactatg cactgggtga      180

agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtactgac aatggtaata      240

caaactataa ccagaagttt aagggcaagg ccacaatgac tgtagacaaa tcctccagca      300

ctgcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat tactgtgcaa      360

gggaggcccg ggactacggt agtatctatg ctttggacta ctggggtcaa ggaacctcag      420

tcaccgtctc tcag                                                        434


<210>  167
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: DNA sequence:

CDR1

<400>  167
ggctacacat tcagtgatta tactatgcac                                        30


<210>  168
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: DNA sequence:

CDR2

<400>  168
gttattagta ctgacaatgg taatacaaac tataaccaga agtttaaggg c                51


<210>  169
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: DNA sequence:

CDR3

<400>  169
gcaagggagg cccgggacta cggtagtatc tatgctttgg actac                       45


<210>  170
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  170

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Ser Asp Tyr Thr Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Asp Asn Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Ala Arg Asp Tyr Gly Ser Ile Tyr Ala Leu 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Gln 
    130                 135                 140     


<210>  171
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acids sequence:

FR1

<400>  171

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  172
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

CDR1

<400>  172

Gly Tyr Thr Phe Ser Asp Tyr Thr Met His 
1               5                   10  


<210>  173
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

FR2

<400>  173

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  174
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

CDR2

<400>  174

Val Ile Ser Thr Asp Asn Gly Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  175
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

FR3

<400>  175

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
            20                  25                  30  


<210>  176
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

CDR3

<400>  176

Ala Arg Glu Ala Arg Asp Tyr Gly Ser Ile Tyr Ala Leu Asp Tyr 
1               5                   10                  15  


<210>  177
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 heavy chain VH: Amino acid sequence:

FR4

<400>  177

Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
1               5                   10  


<210>  178
<211>  395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  178
tattactagt cgacatggtt cttatgttgc tgctgctatg gcttacaggt gccagatgtg       60

acatccagat gactcagtct ccagcctccc tatctgcatc tgtgggagaa actgtcacca      120

tcacatgtcg agcaagtggg aatattcaca attatttagc atggtatcag cagaaacagg      180

gaaaatctcc tcagctcctg gtctataatg caaaaacctt agcagatggt gtgccatcaa      240

ggttcagtgg cagtggatca ggaacacaat attctctcaa gatcaacaac ctgcagcctg      300

aggattttgg gaattattac tgtcaacatt tttggagtac tccgtggacg ttcggtggag      360

gcaccaagct ggaaatcaaa cgggctgatg ctgca                                 395


<210>  179
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: DNA sequence:

CDR1

<400>  179
cgagcaagtg ggaatattca caattat                                           27


<210>  180
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: DNA sequence:

CDR2

<400>  180
aatgcaaaaa ccttagcaga t                                                 21


<210>  181
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: DNA sequence:

CDR3

<400>  181
caacattttt ggagtactcc gtggacg                                           27


<210>  182
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  182

Met Val Leu Met Leu Leu Leu Leu Trp Leu Thr Gly Ala Arg Cys Asp 
1               5                   10                  15      


Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly Glu 
            20                  25                  30          


Thr Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile His Asn Tyr Leu 
        35                  40                  45              


Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val Tyr 
    50                  55                  60                  


Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser 
65                  70                  75                  80  


Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Asn Leu Gln Pro Glu 
                85                  90                  95      


Asp Phe Gly Asn Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Trp Thr 
            100                 105                 110         


Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
        115                 120                 125         


<210>  183
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

FR1

<400>  183

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys 
            20              


<210>  184
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

CDR1

<400>  184

Arg Ala Ser Gly Asn Ile His Asn Tyr 
1               5                   


<210>  185
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

FR2

<400>  185

Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
1               5                   10                  15      


Tyr 
    


<210>  186
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

CDR2

<400>  186

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  187
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

FR3

<400>  187

Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gln Tyr Ser 
1               5                   10                  15      


Leu Lys Ile Asn Asn Leu Gln Pro Glu Asp Phe Gly Asn Tyr Tyr Cys 
            20                  25                  30          


<210>  188
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

CDR3

<400>  188

Gln His Phe Trp Ser Thr Pro Trp Thr 
1               5                   


<210>  189
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3B7 light chain VL: Amino acid sequence:

FR4

<400>  189

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
1               5                   10                  15  


<210>  190
<211>  425
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  190
tactagtcga atgggatgga gctgtatcat gttctttctg gtagctacag ctacaggtgt       60

gcactcccag gtccagctgc agcagtctgg gcctgacctg gtgaggcctg gggtctcagt      120

gaagatttcc tgcaagggtt ccggctacac attcactgat tatgctatgc actgggtaaa      180

gcagagtcat gcaaagagtc tagagtggat tggagttatt agtactgact ctggtactac      240

aaactacaac cagaagttta agggcaaggc cacaatgact gtagacaaat cctccagtac      300

agcctatatg gaccttgcca gattgacatc tgaggattct gccatctatt actgtgcaag      360

agacagctcg tactacgtgc gattttctta ctggggccaa ggaactctgg tcactgtctc      420

tgcag                                                                  425


<210>  191
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: DNA sequence:

CDR1

<400>  191
ggctacacat tcactgatta tgctatgcac                                        30


<210>  192
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: DNA sequence:

CDR2

<400>  192
gttattagta ctgactctgg tactacaaac tacaaccaga agttt                       45


<210>  193
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: DNA sequence:

CDR3

<400>  193
gcaagagaca gctcgtacta cgtgcgattt tcttac                                 36


<210>  194
<211>  138
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  194

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ala Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Asp Ser Gly Thr Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Asp Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Asp Ser Ser Tyr Tyr Val Arg Phe Ser Tyr Trp 
        115                 120                 125             


Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135             


<210>  195
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acids sequence:

FR1

<400>  195

Gln Val Gln Leu Gln Gln Ser Gly Pro Asp Leu Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  196
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

CDR1

<400>  196

Gly Tyr Thr Phe Thr Asp Tyr Ala Met His 
1               5                   10  


<210>  197
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

FR2

<400>  197

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  198
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

CDR2

<400>  198

Val Ile Ser Thr Asp Ser Gly Thr Thr Asn Tyr Asn Gln Lys Phe 
1               5                   10                  15  


<210>  199
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

FR3

<400>  199

Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
1               5                   10                  15      


Met Asp Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
            20                  25                  30          


<210>  200
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

CDR3

<400>  200

Ala Arg Asp Ser Ser Tyr Tyr Val Arg Phe Ser Tyr 
1               5                   10          


<210>  201
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 heavy chain VH: Amino acid sequence:

FR4

<400>  201

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  202
<211>  420
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  202
tactagttgt atattggctt caagatggag tcacagaccc aggtcttcgt atttctactg       60

ctctgtgtgt ctggtgctca tgggagtatt gtgatgaccc agactcccaa attcctgctt      120

gtttcagtag gagacagggt taccataacc tgtaaggcca gtcagagtgt gagtaatgat      180

gtagcttggt accaacagaa gccagggcag tctcctaaac tgctaatata ctatgcatcc      240

aatcgctaca ctggagtccc tgatcgcttc actggcagtg gatatgggac ggatttcact      300

ttcaccatca gcactgtgca ggctgaagac ctggcagttt atttctgtca gcaggattat      360

agttctccgt ggacgttcgg tggaggcacc aagctggaaa tcaaacgggc tgatgctgca      420


<210>  203
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: DNA sequence:

CDR1

<400>  203
aaggccagtc agagtgtgag taatgat                                           27


<210>  204
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: DNA sequence:

CDR2

<400>  204
tatgcatcca atcgctacac t                                                 21


<210>  205
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: DNA sequence:

CDR3

<400>  205
agttctccgt ggacg                                                        15


<210>  206
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  206

Met Glu Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu 
            20                  25                  30          


Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         


Ser Ser Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala 
    130         


<210>  207
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

FR1

<400>  207

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  208
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

CDR1

<400>  208

Lys Ala Ser Gln Ser Val Ser Asn Asp 
1               5                   


<210>  209
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

FR2

<400>  209

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  210
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

CDR2

<400>  210

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  211
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

FR3

<400>  211

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  212
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

CDR3

<400>  212

Gln Gln Asp Tyr Ser Ser Pro Trp Thr 
1               5                   


<210>  213
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  11G8 light chain VL: Amino acid sequence:

FR4

<400>  213

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
1               5                   10                  15  


<210>  214
<211>  434
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  214
tacttgtcga catgggatgg agctgtatca tgttctttct ggtagcaaca gctacaggtg       60

tgcactccca ggtccagctg cagcagtctg ggcctgaggt ggtgaggcct ggggtctcag      120

tgaagatttc ctgcaagggt tccggctaca cattcactga ttatactatg cactgggtga      180

agcagagtca tgcaaagagt ctagagtgga ttggagttat tagtacttac aatggtaata      240

caaactacaa ccagaacttt gagggcaagg ccacaatgac tgtagacaaa tcctccagca      300

cagcctatat ggaacttgcc agattgacat ctgaggattc tgccatctat tactgtgcaa      360

gagagagggg gggggatggt tactacagtg ctgtggacta ctggggtcaa ggaacctcag      420

tcaccgtctc tcag                                                        434


<210>  215
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: DNA sequence:

CDR1

<400>  215
ggctacacat tcactgatta tactatgcac                                        30


<210>  216
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: DNA sequence:

CDR2

<400>  216
gttattagta cttacaatgg taatacaaac tacaaccaga actttgaggg c                51


<210>  217
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: DNA sequence:

CDR3

<400>  217
gcaagagaga ggggggggga tggttactac agtgctgtgg actac                       45


<210>  218
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  218

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Thr Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Asn Phe Glu Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Arg Gly Gly Asp Gly Tyr Tyr Ser Ala Val 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Gln 
    130                 135                 140     


<210>  219
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acids sequence:

FR1

<400>  219

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  220
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

CDR1

<400>  220

Gly Tyr Thr Phe Thr Asp Tyr Thr Met His 
1               5                   10  


<210>  221
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

FR2

<400>  221

Trp Val Lys Gln Ser His Ala Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  222
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

CDR2

<400>  222

Val Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Asn Gln Asn Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  223
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

FR3

<400>  223

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
            20                  25                  30  


<210>  224
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

CDR3

<400>  224

Ala Arg Glu Arg Gly Gly Asp Gly Tyr Tyr Ser Ala Val Asp Tyr 
1               5                   10                  15  


<210>  225
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 heavy chain VH: Amino acid sequence:

FR4

<400>  225

Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
1               5                   10  


<210>  226
<211>  313
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: DNA sequence:

       FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  226
ccaaattcct gcttgtatca gcaggagaca gggttaccat aacctgcaag gccagtcaga       60

gtgtgattaa tgatgtagct tggtaccaac agaagccagg gcagtctcct aaactgctga      120

tatactatgc atccaatcgc tacactggag tccctgatcg cttcactggc agtggatatg      180

ggacggattt cactttcacc atcagcactg tgcaggctga agacctggca gtttatttct      240

gtcagcagga ttatagctct ccgtacacgt tcggaggggg gaccaagctg gaaataaaac      300

gggctgatgc tgc                                                         313


<210>  227
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: DNA sequence:

CDR1

<400>  227
aaggccagtc agagtgtgat taatgat                                           27


<210>  228
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: DNA sequence:

CDR2

<400>  228
tatgcatcca atcgctacac t                                                 21


<210>  229
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: DNA sequence:

CDR3

<400>  229
cagcaggatt atagctctcc gtacacg                                           27


<210>  230
<211>  103
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

       FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  230

Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys 
1               5                   10                  15      


Ala Ser Gln Ser Val Ile Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro 
            20                  25                  30          


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr 
        35                  40                  45              


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
    50                  55                  60                  


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
65                  70                  75                  80  


Gln Gln Asp Tyr Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
                85                  90                  95      


Glu Ile Lys Arg Ala Asp Ala 
            100             


<210>  231
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

FR1

<400>  231

Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15  


<210>  232
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

CDR1

<400>  232

Lys Ala Ser Gln Ser Val Ile Asn Asp 
1               5                   


<210>  233
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

FR2

<400>  233

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  234
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

CDR2

<400>  234

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  235
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

FR3

<400>  235

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  236
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

CDR3

<400>  236

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  237
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  14F8 light chain VL: Amino acid sequence:

FR4

<400>  237

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
1               5                   10                  


<210>  238
<211>  421
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  238
tggggaattc atggagttgg ggttcagctt gattttcctt gtccttgttt taaaaggtgt       60

ccagtgtgaa gtgatgctgg tggagtctgg gggaggctta gtgaagcctg gagggtccct      120

gaaactctcc tgtgcagcct ctggattcac tttcagtaac tatgccatgt cttgggttcg      180

ccagactccg gagaagaggc tggagtgggt cgcaacctct cttagtggtg gtaattacac      240

ctactatcca gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagagcac      300

cctgtacctg caaatgagca gtctgaggtc tgaggacacg gccatgtatt actgtgtaat      360

cccccaaggt agtagtcctt ttgactattg gggccaaggc accactctca cagtctctca      420

g                                                                      421


<210>  239
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: DNA sequence:

CDR1

<400>  239
ggattcactt tcagtaacta tgccatgtct                                        30


<210>  240
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: DNA sequence:

CDR2

<400>  240
acctctctta gtggtggtaa ttacacctac tatccagaca gtgtgaaggg g                51


<210>  241
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: DNA sequence:

CDR3

<400>  241
gtaatccccc aaggtagtag tccttttgac tat                                    33


<210>  242
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  242

Met Glu Leu Gly Phe Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asn Tyr Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ser Leu Ser Gly Gly Asn Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Val Ile Pro Gln Gly Ser Ser Pro Phe Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Leu Thr Val Ser 
    130                 135     


<210>  243
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acids sequence:

FR1

<400>  243

Glu Val Met Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  244
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

CDR1

<400>  244

Gly Phe Thr Phe Ser Asn Tyr Ala Met Ser 
1               5                   10  


<210>  245
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

FR2

<400>  245

Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val Ala 
1               5                   10                  


<210>  246
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

CDR2

<400>  246

Thr Ser Leu Ser Gly Gly Asn Tyr Thr Tyr Tyr Pro Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  247
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

FR3

<400>  247

Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr Leu Gln 
1               5                   10                  15      


Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
            20                  25                  30  


<210>  248
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

CDR3

<400>  248

Val Ile Pro Gln Gly Ser Ser Pro Phe Asp Tyr 
1               5                   10      


<210>  249
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 heavy chain VH: Amino acid sequence:

FR4

<400>  249

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser 
1               5                   10  


<210>  250
<211>  417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  250
tactagtcga catgggcttc aagatggagt cacagattca ggttttggta tttttactgc       60

tctgtgtgtg tggtggtcat gggagtattg tgatgaccca gactcccaaa ttccctattg      120

tttcagtagg agacagggtt accataacct gtaaggccag tcagagtgtg aaaaatgatg      180

tagcatggta ccaacagaag ccagggcagt ctggtaaaat gttaatatat tatgcatgca      240

atcgctacac gggagtcctt gatcgcttca ctgtcagtgg atatgtgacg gatttcactt      300

tcaccatcac cactgtgcag gctgaagacc tggcagttta cttttgtcag caggatcata      360

gttatccgtg gacgttcggt gctgggacca agctggagct gaaacgggct gatgctg         417


<210>  251
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: DNA sequence:

CDR1

<400>  251
aaggccagtc agagtgtgaa aaatgatgta gca                                    33


<210>  252
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: DNA sequence:

CDR2

<400>  252
tatgcatgca atcgctacac g                                                 21


<210>  253
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: DNA sequence:

CDR3

<400>  253
cagcaggatc atagttatcc gtggacg                                           27


<210>  254
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  254

Met Gly Phe Lys Met Glu Ser Gln Ile Gln Val Leu Val Phe Leu Leu 
1               5                   10                  15      


Leu Cys Val Cys Gly Gly His Gly Ser Ile Val Met Thr Gln Thr Pro 
            20                  25                  30          


Lys Phe Pro Ile Val Ser Val Gly Asp Arg Val Thr Ile Thr Cys Lys 
        35                  40                  45              


Ala Ser Gln Ser Val Lys Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Gly Lys Met Leu Ile Tyr Tyr Ala Cys Asn Arg Tyr Thr 
65                  70                  75                  80  


Gly Val Leu Asp Arg Phe Thr Val Ser Gly Tyr Val Thr Asp Phe Thr 
                85                  90                  95      


Phe Thr Ile Thr Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            100                 105                 110         


Gln Gln Asp His Ser Tyr Pro Trp Thr Phe Gly Ala Gly Thr Lys Leu 
        115                 120                 125             


Glu Leu Lys 
    130     


<210>  255
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

FR1

<400>  255

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Pro Ile Val Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  256
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

CDR1

<400>  256

Lys Ala Ser Gln Ser Val Lys Asn Asp Val Ala 
1               5                   10      


<210>  257
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

FR2

<400>  257

Trp Tyr Gln Gln Lys Pro Gly Gln Ser Gly Lys Met Leu Ile Tyr 
1               5                   10                  15  


<210>  258
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

CDR2

<400>  258

Tyr Ala Cys Asn Arg Tyr Thr 
1               5           


<210>  259
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

FR3

<400>  259

Gly Val Leu Asp Arg Phe Thr Val Ser Gly Tyr Val Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Thr Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  260
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

CDR3

<400>  260

Gln Gln Asp His Ser Tyr Pro Trp Thr 
1               5                   


<210>  261
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  15D2 light chain VL: Amino acid sequence:

FR4

<400>  261

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  262
<211>  438
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  262
tattactagt cgccatggga tggagctgta tcatgttctt tctggtagca acagctacag       60

gtgtgcactc ccaggtccag ctgcagcagt ctgggcctga ggtggtgagg cctggggtct      120

cagtgaagat ttcctgcaag ggttccggct acacattcac tgattatgtt atgcactggg      180

tgaagcagag tcatggaaag agtctagagt ggattggagt tattagtact tacaatggta      240

atacaaacta caaccagaag tttaagggca aggccacaat gactgtagac aaatcctcca      300

gcacagccta tatggaactt gccagattga catctgagga ttctgccatc tattactgtg      360

caagagagag ggggggggat ggttactaca gtgctatgga ctactggggt caaggaacct      420

cagtcaccgt ctcctcag                                                    438


<210>  263
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: DNA sequence:

CDR1

<400>  263
ggctacacat tcactgatta tgttatgcac                                        30


<210>  264
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: DNA sequence:

CDR2

<400>  264
gttattagta cttacaatgg taatacaaac tacaaccaga agtttaaggg c                51


<210>  265
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: DNA sequence:

CDR3

<400>  265
gcaagagaga ggggggggga tggttactac agtgctatgg actac                       45


<210>  266
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  266

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Val Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Arg Gly Gly Asp Gly Tyr Tyr Ser Ala Met 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
    130                 135                 140     


<210>  267
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acids sequence:

FR1

<400>  267

Gln Val Gln Leu Gln Gln Ser Gly Pro Glu Val Val Arg Pro Gly Val 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Gly Ser 
            20                  25  


<210>  268
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

CDR1

<400>  268

Gly Tyr Thr Phe Thr Asp Tyr Val Met His 
1               5                   10  


<210>  269
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

FR2

<400>  269

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  270
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

CDR2

<400>  270

Val Ile Ser Thr Tyr Asn Gly Asn Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  271
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

FR3

<400>  271

Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr Met Glu 
1               5                   10                  15      


Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
            20                  25                  30  


<210>  272
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

CDR3

<400>  272

Ala Arg Glu Arg Gly Gly Asp Gly Tyr Tyr Ser Ala Met Asp Tyr 
1               5                   10                  15  


<210>  273
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 heavy chain VH: Amino acid sequence:

FR4

<400>  273

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  274
<211>  389
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  274
acaggagccg ggtgttggta tttctactgc tctgtgtgtc tggtgctcat gggagtattg       60

tgatgaccca gactcccaaa ttcctgcttg tttcagcagg agacagggtt accatagcct      120

gcaaggccag tcagagtgtg attaataatg tagcttggta ccaacagaag ccagggcagt      180

ctcctgaact gctgatatac tatgcatcca atcgctacac tggagtccct gatcgcttca      240

ctggcagtgg atatgggacg gatttcactt tcaccatcac cactgtgcag gctgaagacc      300

tggcagttta tttctgtcag caggattata gctctccgta cacgttcgga ggggggacca      360

agctggaaat aaaacgggct gatgctgca                                        389


<210>  275
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: DNA sequence:

CDR1

<400>  275
aaggccagtc agagtgtgat taataat                                           27


<210>  276
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: DNA sequence:

CDR2

<400>  276

Thr Ala Thr Gly Cys Ala Thr Cys Cys Ala Ala Thr Cys Gly Cys Thr 
1               5                   10                  15      


Ala Cys Ala Cys Thr 
            20      


<210>  277
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: DNA sequence:

CDR3

<400>  277

Cys Ala Gly Cys Ala Gly Gly Ala Thr Thr Ala Thr Ala Gly Cys Thr 
1               5                   10                  15      


Cys Thr Cys Cys Gly Thr Ala Cys Ala Cys Gly 
            20                  25          


<210>  278
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  278

Arg Ser Arg Val Leu Val Phe Leu Leu Leu Cys Val Ser Gly Ala His 
1               5                   10                  15      


Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala 
            20                  25                  30          


Gly Asp Arg Val Thr Ile Ala Cys Lys Ala Ser Gln Ser Val Ile Asn 
        35                  40                  45              


Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu 
    50                  55                  60                  


Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr 
65                  70                  75                  80  


Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Thr Thr Val Gln 
                85                  90                  95      


Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr Ser Ser Pro 
            100                 105                 110         


Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
        115                 120                 125             


Ala 
    


<210>  279
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

FR1

<400>  279

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ala Cys 
            20              


<210>  280
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

CDR1

<400>  280

Lys Ala Ser Gln Ser Val Ile Asn Asn 
1               5                   


<210>  281
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

FR2

<400>  281

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  282
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

CDR2

<400>  282

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  283
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

FR3

<400>  283

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Thr Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  284
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

CDR3

<400>  284

Gln Gln Asp Tyr Ser Ser Pro Tyr Thr 
1               5                   


<210>  285
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  29H7 light chain VL: Amino acid sequence:

FR4

<400>  285

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
1               5                   10                  15  


<210>  286
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  286
tggggaattc caggaatgga gctgggtttt tctcttcctg atggcagtgg ttacaggggt       60

caattcagag gttcagctgc agcagtctgg ggctgagctt gtgaggccag gggccttagt      120

caagttgtcc tgcaaagctt ctggcttcaa ctttaaagac tactttatgc actgggtgaa      180

gcagaggcct gaacagggcc tggagtggat tggatggatt gatcctgaaa atggtaatac      240

tatatatgaa ccgaagttcc agggcaaggc cagtataaca gcagacacat cctccaacac      300

agcctacctg cagctcagca gcctgacatc tgaggacact gccgtctatt actgtgctag      360

agggggggta ggtcactggt acttcgatgt ctggggcgca gggaccacgg tcaccgtctc      420

tcag                                                                   424


<210>  287
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: DNA sequence:

CDR1

<400>  287
ggcttcaact ttaaagacta ctttatgcac                                        30


<210>  288
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: DNA sequence:

CDR2

<400>  288
attgatcctg aaaatggtaa tactatatat gaaccgaagt tccagggc                    48


<210>  289
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: DNA sequence:

CDR3

<400>  289
gctagagggg gggtaggtca ctggtacttc gatgtc                                 36


<210>  290
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  290

Gly Glu Phe Gln Glu Trp Ser Trp Val Phe Leu Phe Leu Met Ala Val 
1               5                   10                  15      


Val Thr Gly Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Glu 
            20                  25                  30          


Leu Val Arg Pro Gly Ala Leu Val Lys Leu Ser Cys Lys Ala Ser Gly 
        35                  40                  45              


Phe Asn Phe Lys Asp Tyr Phe Met His Trp Val Lys Gln Arg Pro Glu 
    50                  55                  60                  


Gln Gly Leu Glu Trp Ile Gly Trp Ile Asp Pro Glu Asn Gly Asn Thr 
65                  70                  75                  80  


Ile Tyr Glu Pro Lys Phe Gln Gly Lys Ala Ser Ile Thr Ala Asp Thr 
                85                  90                  95      


Ser Ser Asn Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly Val Gly His Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
    130                 135                 140 


<210>  291
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acids sequence:

FR1

<400>  291

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Leu Val Lys Leu Ser Cys Lys Ala Ser 
            20                  25  


<210>  292
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

CDR1

<400>  292

Gly Phe Asn Phe Lys Asp Tyr Phe Met His 
1               5                   10  


<210>  293
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

FR2

<400>  293

Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly Trp 
1               5                   10                  15  


<210>  294
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

CDR2

<400>  294

Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Glu Pro Lys Phe Gln Gly 
1               5                   10                  15      


<210>  295
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

FR3

<400>  295

Lys Ala Ser Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr Leu Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  296
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

CDR3

<400>  296

Ala Arg Gly Gly Val Gly His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  297
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 heavy chain VH: Amino acid sequence:

FR4

<400>  297

Trp Gly Ala Gly Thr Thr Val Thr Val Ser 
1               5                   10  


<210>  298
<211>  417
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  298

Thr Gly Gly Gly Ala Ala Thr Thr Cys Ala Thr Gly Gly Ala Gly Ala 
1               5                   10                  15      


Cys Ala Gly Ala Cys Ala Cys Ala Cys Thr Cys Cys Thr Gly Cys Thr 
            20                  25                  30          


Ala Thr Gly Gly Gly Thr Gly Cys Thr Gly Cys Thr Gly Cys Thr Thr 
        35                  40                  45              


Thr Gly Gly Gly Thr Thr Cys Cys Ala Gly Gly Cys Thr Cys Cys Ala 
    50                  55                  60                  


Cys Thr Gly Gly Thr Gly Ala Cys Ala Thr Thr Gly Thr Gly Cys Thr 
65                  70                  75                  80  


Gly Ala Cys Cys Cys Ala Ala Thr Cys Thr Cys Cys Ala Gly Cys Thr 
                85                  90                  95      


Thr Cys Thr Thr Thr Gly Gly Cys Thr Gly Thr Gly Thr Cys Thr Cys 
            100                 105                 110         


Thr Ala Gly Gly Gly Cys Ala Gly Ala Gly Gly Gly Cys Cys Ala Cys 
        115                 120                 125             


Cys Ala Thr Cys Thr Cys Thr Thr Gly Cys Ala Ala Gly Gly Cys Cys 
    130                 135                 140                 


Ala Gly Cys Cys Ala Ala Ala Gly Thr Gly Thr Thr Gly Ala Thr Thr 
145                 150                 155                 160 


Ala Thr Gly Ala Thr Gly Gly Thr Gly Ala Thr Ala Gly Thr Thr Ala 
                165                 170                 175     


Thr Ala Thr Gly Ala Ala Cys Thr Gly Gly Thr Ala Cys Cys Ala Ala 
            180                 185                 190         


Cys Ala Gly Ala Ala Ala Cys Cys Ala Gly Gly Ala Cys Ala Gly Cys 
        195                 200                 205             


Cys Ala Cys Cys Cys Ala Ala Ala Cys Thr Cys Cys Thr Cys Ala Thr 
    210                 215                 220                 


Thr Thr Ala Thr Gly Thr Thr Gly Cys Ala Thr Cys Cys Ala Ala Thr 
225                 230                 235                 240 


Cys Thr Ala Ala Ala Ala Thr Cys Thr Gly Gly Gly Ala Thr Cys Cys 
                245                 250                 255     


Cys Ala Gly Cys Cys Ala Gly Gly Thr Thr Thr Ala Gly Thr Gly Gly 
            260                 265                 270         


Cys Ala Gly Thr Gly Gly Gly Thr Gly Thr Gly Gly Gly Ala Cys Ala 
        275                 280                 285             


Gly Ala Cys Thr Thr Cys Ala Cys Cys Cys Thr Cys Ala Ala Cys Ala 
    290                 295                 300                 


Thr Cys Cys Ala Thr Cys Cys Thr Gly Thr Gly Gly Ala Gly Gly Ala 
305                 310                 315                 320 


Gly Gly Ala Gly Gly Ala Thr Gly Gly Thr Gly Cys Ala Ala Cys Cys 
                325                 330                 335     


Thr Ala Thr Thr Ala Cys Thr Gly Thr Cys Ala Gly Cys Ala Ala Ala 
            340                 345                 350         


Cys Thr Ala Ala Thr Gly Ala Gly Gly Ala Thr Cys Cys Gly Thr Gly 
        355                 360                 365             


Gly Ala Cys Gly Thr Thr Cys Gly Gly Thr Gly Gly Ala Gly Gly Cys 
    370                 375                 380                 


Ala Cys Cys Ala Ala Gly Cys Thr Gly Gly Ala Ala Ala Thr Cys Ala 
385                 390                 395                 400 


Ala Ala Cys Gly Gly Gly Cys Thr Gly Ala Thr Gly Cys Thr Gly Cys 
                405                 410                 415     


Ala 
    


<210>  299
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: DNA sequence:

CDR1

<400>  299
aaggccagcc aaagtgttga ttatgatggt gatagttat                              39


<210>  300
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: DNA sequence:

CDR2

<400>  300
gttgcatcca atctaaaatc t                                                 21


<210>  301
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: DNA sequence:

CDR3

<400>  301
cagcaaacta atgaggatcc gtggacg                                           27


<210>  302
<211>  131
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  302

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala 
            20                  25                  30          


Val Ser Leu Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Val Ala Ser Asn Leu Lys Ser 
65                  70                  75                  80  


Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Cys Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Gly Ala Thr Tyr Tyr Cys 
            100                 105                 110         


Gln Gln Thr Asn Glu Asp Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys 
    130     


<210>  303
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

FR1

<400>  303

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys 
            20              


<210>  304
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

CDR1

<400>  304

Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr 
1               5                   10              


<210>  305
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

FR2

<400>  305

Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  306
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

CDR2

<400>  306

Val Ala Ser Asn Leu Lys Ser 
1               5           


<210>  307
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

FR3

<400>  307

Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Cys Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Asn Ile His Pro Val Glu Glu Glu Asp Gly Ala Thr Tyr Tyr Cys 
            20                  25                  30          


<210>  308
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

CDR3

<400>  308

Gln Gln Thr Asn Glu Asp Pro Trp Thr 
1               5                   


<210>  309
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  30D10 light chain VL: Amino acid sequence:

FR4

<400>  309

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  310
<211>  424
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  310
tggggaattc aggaatggag ctgggttttt ctctttctcc tgtcaggaac tgcaggtgtc       60

ctctctgagg tccagctgca acagtctgga cctgagctgg tgaagcctgg ggcttcagtg      120

aagatatcct gcaagacttc tggatacaca ttcactgaat acatcatgca ctgggtgaaa      180

cagagccatg gaaagagcct tgagtggatt ggaggtatta atcctaataa tggtggtact      240

aactacaacc agaagtttaa gggcaaggcc acattgactg tagacacgtc ctccagcata      300

gcctacatgg aactccgcag cctgacatct gaagattctg cagtctatta ttgtgcaaga      360

gacgatggtt actacgtaaa gttcgcttac tggggccaag ggactctggt cactgtctct      420

gcag                                                                   424


<210>  311
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: DNA sequence:

CDR1

<400>  311
tctggataca cattcactga atacatcatg cac                                    33


<210>  312
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: DNA sequence:

CDR2

<400>  312
ggtattaatc ctaataatgg tggtactaac tacaaccaga agtttaaggg c                51


<210>  313
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: DNA sequence:

CDR3

<400>  313
gcaagagacg atggttacta cgtaaagttc gcttac                                 36


<210>  314
<211>  141
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  314

Trp Gly Ile Gln Glu Trp Ser Trp Val Phe Leu Phe Leu Leu Ser Gly 
1               5                   10                  15      


Thr Ala Gly Val Leu Ser Glu Val Gln Leu Gln Gln Ser Gly Pro Glu 
            20                  25                  30          


Leu Val Lys Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Thr Ser Gly 
        35                  40                  45              


Tyr Thr Phe Thr Glu Tyr Ile Met His Trp Val Lys Gln Ser His Gly 
    50                  55                  60                  


Lys Ser Leu Glu Trp Ile Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr 
65                  70                  75                  80  


Asn Tyr Asn Gln Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr 
                85                  90                  95      


Ser Ser Ser Ile Ala Tyr Met Glu Leu Arg Ser Leu Thr Ser Glu Asp 
            100                 105                 110         


Ser Ala Val Tyr Tyr Cys Ala Arg Asp Asp Gly Tyr Tyr Val Lys Phe 
        115                 120                 125             


Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
    130                 135                 140     


<210>  315
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acids sequence:

FR1

<400>  315

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr 
            20                  


<210>  316
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

CDR1

<400>  316

Ser Gly Tyr Thr Phe Thr Glu Tyr Ile Met His 
1               5                   10      


<210>  317
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

FR2

<400>  317

Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  318
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

CDR2

<400>  318

Gly Ile Asn Pro Asn Asn Gly Gly Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  319
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

FR3

<400>  319

Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Ile Ala Tyr Met Glu 
1               5                   10                  15      


Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            20                  25                  30  


<210>  320
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

CDR3

<400>  320

Ala Arg Asp Asp Gly Tyr Tyr Val Lys Phe Ala Tyr 
1               5                   10          


<210>  321
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 heavy chain VH: Amino acid sequence:

FR4

<400>  321

Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
1               5                   10      


<210>  322
<211>  419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: DNA sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  322
tactagttga catgggcttc aagatggagt cacagactca ggtcttcgta tttctactgc       60

tctgtgtgtc tggtgctcat gggagtattg tgatgaccca gactcccaaa ttcctgcttg      120

tatcagcagg agacagggtt accataacct gcaaggccag tcagagtgtg attaatgatg      180

tagcttggta ccaacagaag ccagggcagt ctcctaaact gctgatatac tatgcatcca      240

atcgctacac tggagtccct gatcgcttca ctggcagtgg atatgggacg gatttcactt      300

tcaccatcag cactgtgcag gctgaagacc tggcagttta tttctgtcag caggattata      360

gctctccatt cacgttcggc tcggggacaa agttggaaat aaaacgggct gatgctgca       419


<210>  323
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: DNA sequence:

CDR1

<400>  323
aaggccagtc agagtgtgat taatgat                                           27


<210>  324
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: DNA sequence:

CDR2

<400>  324
tatgcatcca atcgctacac t                                                 21


<210>  325
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: DNA sequence:

CDR3

<400>  325
cagcaggatt atagctctcc attcacg                                           27


<210>  326
<211>  136
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

       Leader sequence-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4

<400>  326

Met Gly Phe Lys Met Glu Ser Gln Thr Gln Val Phe Val Phe Leu Leu 
1               5                   10                  15      


Leu Cys Val Ser Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro 
            20                  25                  30          


Lys Phe Leu Leu Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys 
        35                  40                  45              


Ala Ser Gln Ser Val Ile Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Tyr Ala Ser Asn Arg Tyr Thr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
                85                  90                  95      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            100                 105                 110         


Gln Gln Asp Tyr Ser Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Ala Asp Ala Ala 
    130                 135     


<210>  327
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

FR1

<400>  327

Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu Val Ser Ala Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys 
            20              


<210>  328
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

CDR1

<400>  328

Lys Ala Ser Gln Ser Val Ile Asn Asp 
1               5                   


<210>  329
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

FR2

<400>  329

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  330
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

CDR2

<400>  330

Tyr Ala Ser Asn Arg Tyr Thr 
1               5           


<210>  331
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

FR3

<400>  331

Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr 
1               5                   10                  15      


Phe Thr Ile Ser Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys 
            20                  25                  30          


<210>  332
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

CDR3

<400>  332

Gln Gln Asp Tyr Ser Ser Pro Phe Thr 
1               5                   


<210>  333
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  51C3 light chain VL: Amino acid sequence:

FR4

<400>  333

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala Ala 
1               5                   10                  15  


<210>  334
<211>  1233
<212>  DNA
<213>  Homo sapiens

<400>  334
atgtcgctca tggtcgtcag catggcgtgt gttgggttct tcttgctgga ggggccctgg       60

ccacatgtgg gtggtcagga caagcccttc ctctctgcct ggcccggcac tgtggtgtct      120

gaaggacaac atgtgactct tcagtgtcgc tctcgtcttg ggtttaatga attcagtctg      180

tccaaagaag acgggatgcc tgtccctgag ctctacaaca gaatattccg gaacagcttt      240

ctcatgggcc ctgtgacccc agcacatgca gggacctaca gatgttgcag ttcacaccca      300

cactccccca ctgggtggtc ggcacccagc aaccctgtgg tgatcatggt cacaggagtc      360

cacagaaaac cttccctcct ggcccaccca ggtcccctgg tgaaatcagg agagacggtc      420

atcctgcaat gttggtcaga tgtcaggttt gagcgcttcc ttctgcacag agaggggatc      480

actgaggacc ccttgcgcct cgttggacag ctccacgatg cgggttccca ggtcaactat      540

tccatgggtc ccatgacacc tgcccttgca gggacctaca gatgctttgg ttctgtcact      600

cacttaccct atgagttgtc ggctcccagt gaccctctgg acatcgtggt cgtaggtcta      660

tatgggaaac cttctctctc agcccagccg ggccccacgg ttcaggcagg agagaatgtg      720

accttgtcct gcagctcccg gagcttgttt gacatttacc atctatccag ggaggcggag      780

gccggtgaac ttaggctcac tgcagtgctg agggtcaatg gaacattcca ggccaacttc      840

cctctgggcc ctgtgaccca cggagggaac tacagatgct tcggctcttt ccgtgccctg      900

ccccatgcgt ggtcagaccc gagtgaccca ctgcccgttt ctgtcacagg taactccaga      960

aacctgcacg ttctgattgg gacctcagtg gtcatcatcc cctttgctat cctcctcttc     1020

tttctccttc atcgctggtg tgccaacaaa aagaatgctg ttgtaatgga ccaagagcct     1080

gcagggaaca gaacagtgaa cagggaggac tctgatgaac aagaccctca ggaggtgaca     1140

tacgcacagt tgaatcactg cgttttcaca cagagaaaaa tcactcgccc ttctcagagg     1200

cccaagacac ccccaacaga taccagcgtg taa                                  1233


<210>  335
<211>  410
<212>  PRT
<213>  Homo sapiens

<400>  335

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly Gln Asp Lys Pro Phe Leu Ser 
            20                  25                  30          


Ala Trp Pro Gly Thr Val Val Ser Glu Gly Gln His Val Thr Leu Gln 
        35                  40                  45              


Cys Arg Ser Arg Leu Gly Phe Asn Glu Phe Ser Leu Ser Lys Glu Asp 
    50                  55                  60                  


Gly Met Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Arg Asn Ser Phe 
65                  70                  75                  80  


Leu Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Cys 
                85                  90                  95      


Ser Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro 
            100                 105                 110         


Val Val Ile Met Val Thr Gly Val His Arg Lys Pro Ser Leu Leu Ala 
        115                 120                 125             


His Pro Gly Pro Leu Val Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
    130                 135                 140                 


Trp Ser Asp Val Arg Phe Glu Arg Phe Leu Leu His Arg Glu Gly Ile 
145                 150                 155                 160 


Thr Glu Asp Pro Leu Arg Leu Val Gly Gln Leu His Asp Ala Gly Ser 
                165                 170                 175     


Gln Val Asn Tyr Ser Met Gly Pro Met Thr Pro Ala Leu Ala Gly Thr 
            180                 185                 190         


Tyr Arg Cys Phe Gly Ser Val Thr His Leu Pro Tyr Glu Leu Ser Ala 
        195                 200                 205             


Pro Ser Asp Pro Leu Asp Ile Val Val Val Gly Leu Tyr Gly Lys Pro 
    210                 215                 220                 


Ser Leu Ser Ala Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val 
225                 230                 235                 240 


Thr Leu Ser Cys Ser Ser Arg Ser Leu Phe Asp Ile Tyr His Leu Ser 
                245                 250                 255     


Arg Glu Ala Glu Ala Gly Glu Leu Arg Leu Thr Ala Val Leu Arg Val 
            260                 265                 270         


Asn Gly Thr Phe Gln Ala Asn Phe Pro Leu Gly Pro Val Thr His Gly 
        275                 280                 285             


Gly Asn Tyr Arg Cys Phe Gly Ser Phe Arg Ala Leu Pro His Ala Trp 
    290                 295                 300                 


Ser Asp Pro Ser Asp Pro Leu Pro Val Ser Val Thr Gly Asn Ser Arg 
305                 310                 315                 320 


Asn Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala 
                325                 330                 335     


Ile Leu Leu Phe Phe Leu Leu His Arg Trp Cys Ala Asn Lys Lys Asn 
            340                 345                 350         


Ala Val Val Met Asp Gln Glu Pro Ala Gly Asn Arg Thr Val Asn Arg 
        355                 360                 365             


Glu Asp Ser Asp Glu Gln Asp Pro Gln Glu Val Thr Tyr Ala Gln Leu 
    370                 375                 380                 


Asn His Cys Val Phe Thr Gln Arg Lys Ile Thr Arg Pro Ser Gln Arg 
385                 390                 395                 400 


Pro Lys Thr Pro Pro Thr Asp Thr Ser Val 
                405                 410 


<210>  336
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  336

Met Ser Leu Met Val Val Ser Met Ala Cys Val Gly Phe Phe Leu Leu 
1               5                   10                  15      


Glu Gly Pro Trp Pro His Val Gly Gly 
            20                  25  


<210>  337
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  337

Trp Pro Gly Thr Val Val Ser Glu Gly Gln His Val Thr Leu Gln Cys 
1               5                   10                  15      


Arg Ser Arg Leu Gly Phe Asn Glu Phe Ser Leu Ser Lys Glu Asp Gly 
            20                  25                  30          


Met Pro Val Pro Glu Leu Tyr Asn Arg Ile Phe Arg Asn Ser Phe Leu 
        35                  40                  45              


Met Gly Pro Val Thr Pro Ala His Ala Gly Thr Tyr Arg Cys Cys Ser 
    50                  55                  60                  


Ser His Pro His Ser Pro Thr Gly Trp Ser Ala Pro Ser Asn Pro Val 
65                  70                  75                  80  


Val Ile Met Val Thr 
                85  


<210>  338
<211>  90
<212>  PRT
<213>  Homo sapiens

<400>  338

His Pro Gly Pro Leu Val Lys Ser Gly Glu Thr Val Ile Leu Gln Cys 
1               5                   10                  15      


Trp Ser Asp Val Arg Phe Glu Arg Phe Leu Leu His Arg Glu Gly Ile 
            20                  25                  30          


Thr Glu Asp Pro Leu Arg Leu Val Gly Gln Leu His Asp Ala Gly Ser 
        35                  40                  45              


Gln Val Asn Tyr Ser Met Gly Pro Met Thr Pro Ala Leu Ala Gly Thr 
    50                  55                  60                  


Tyr Arg Cys Phe Gly Ser Val Thr His Leu Pro Tyr Glu Leu Ser Ala 
65                  70                  75                  80  


Pro Ser Asp Pro Leu Asp Ile Val Val Val 
                85                  90  


<210>  339
<211>  97
<212>  PRT
<213>  Homo sapiens

<400>  339

Gln Pro Gly Pro Thr Val Gln Ala Gly Glu Asn Val Thr Leu Ser Cys 
1               5                   10                  15      


Ser Ser Arg Ser Leu Phe Asp Ile Tyr His Leu Ser Arg Glu Ala Glu 
            20                  25                  30          


Ala Gly Glu Leu Arg Leu Thr Ala Val Leu Arg Val Asn Gly Thr Phe 
        35                  40                  45              


Gln Ala Asn Phe Pro Leu Gly Pro Val Thr His Gly Gly Asn Tyr Arg 
    50                  55                  60                  


Cys Phe Gly Ser Phe Arg Ala Leu Pro His Ala Trp Ser Asp Pro Ser 
65                  70                  75                  80  


Asp Pro Leu Pro Val Ser Val Thr Gly Asn Ser Arg Asn Leu His Val 
                85                  90                  95      


Leu 
    


<210>  340
<211>  23
<212>  PRT
<213>  Homo sapiens

<400>  340

Asn Leu His Val Leu Ile Gly Thr Ser Val Val Ile Ile Pro Phe Ala 
1               5                   10                  15      


Ile Leu Leu Phe Phe Leu Leu 
            20              


<210>  341
<211>  60
<212>  PRT
<213>  Homo sapiens

<400>  341

His Arg Trp Cys Ala Asn Lys Lys Asn Ala Val Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Val Asn Arg Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


Pro Gln Glu Val Thr Tyr Ala Gln Leu Asn His Cys Val Phe Thr Gln 
        35                  40                  45              


Arg Lys Ile Thr Arg Pro Ser Gln Arg Pro Lys Thr 
    50                  55                  60  


<210>  342
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  342

Val Thr Tyr Ala Gln Leu 
1               5       


