                              SEQUENCE LISTING

<110> CHILDREN'S MEDICAL CENTER CORPORATION
      DANA-FARBER CANCER INSTITUTE, INC.
 
<120> COMPOSITIONS AND METHODS FOR TREATING ALZHEIMER'S DISEASE

<130> 167705-016801/PCT

<140> PCT/US2020/053824
<141> 2020-10-01

<150> 62/908,913
<151> 2019-10-01

<160> 19    

<170> PatentIn version 3.5

<210> 1
<211> 189
<212> PRT
<213> Homo sapiens

<400> 1
Met Lys Val Leu Trp Ala Ala Leu Leu Val Thr Phe Leu Ala Gly Cys 
1               5                   10                  15      


Gln Ala Lys Val Glu Gln Ala Val Glu Thr Glu Pro Glu Pro Glu Leu 
            20                  25                  30          


Arg Gln Gln Thr Glu Trp Gln Ser Gly Gln Arg Trp Glu Leu Ala Leu 
        35                  40                  45              


Gly Arg Phe Trp Asp Tyr Leu Arg Trp Val Gln Thr Leu Ser Glu Gln 
    50                  55                  60                  


Val Gln Glu Glu Leu Leu Ser Ser Gln Val Thr Gln Glu Leu Arg Ala 
65                  70                  75                  80  


Leu Met Asp Glu Thr Met Lys Glu Leu Lys Ala Tyr Lys Ser Glu Leu 
                85                  90                  95      


Glu Glu Gln Leu Thr Pro Val Ala Glu Glu Thr Arg Ala Arg Leu Ser 
            100                 105                 110         


Lys Glu Leu Gln Ala Ala Gln Ala Arg Leu Gly Ala Asp Met Glu Asp 
        115                 120                 125             


Val Arg Ala Lys Leu Glu Glu Gln Ala Gln Gln Ile Arg Leu Gln Ala 
    130                 135                 140                 


Glu Ala Phe Gln Ala Arg Leu Lys Ser Trp Phe Glu Pro Leu Val Glu 
145                 150                 155                 160 


Asp Met Gln Arg Gln Trp Ala Gly Leu Val Glu Lys Val Gln Ala Ala 
                165                 170                 175     


Val Gly Thr Ser Ala Ala Pro Val Pro Ser Asp Asn His 
            180                 185                 


<210> 2
<211> 567
<212> DNA
<213> Homo sapiens

<400> 2
atgaaggttc tgtgggctgc gttgctggtc acattcctgg caggatgcca ggccaaggtg       60

gagcaagcgg tggagacaga gccggagccc gagctgcgcc agcagaccga gtggcagagc      120

ggccagcgct gggaactggc actgggtcgc ttttgggatt acctgcgctg ggtgcagaca      180

ctgtctgagc aggtgcagga ggagctgctc agctcccagg tcacccagga actgagggcg      240

ctgatggacg agaccatgaa ggagttgaag gcctacaaat cggaactgga ggaacaactg      300

accccggtgg cggaggagac gcgggcacgg ctgtccaagg agctgcaggc ggcgcaggcc      360

cggctgggcg cggacatgga ggacgtgcgc gccaagctgg aggagcaggc ccagcagata      420

cgcctgcagg ccgaggcctt ccaggcccgc ctcaagagct ggttcgagcc cctggtggaa      480

gacatgcagc gccagtgggc cgggctggtg gagaaggtgc aggctgccgt gggcaccagc      540

gccgcccctg tgcccagcga caatcac                                          567


<210> 3
<211> 512
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
agactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaaagag agagagaaaa aggaagttag       60

aaaaacagcc ctagaggccc tacattctga gtaataggag ttccagaaag gaagtgattg      120

ctgcacaaca taaatttgaa aagaaagaga agtgagaaaa tagagggaag gaaatcaaag      180

aaataatcca acttctgaaa agtaaagaat gagcttccag cgggaaagtg cctgttgagt      240

gcaggcacag tggaggaaat gaagctgggt gtgttgccag gagttggaaa cttgtctgag      300

caacatagcg cgaccctgtg tctacaaaaa aataaaaaca aaacaaaaaa caaccaaaga      360

cttccgaaac agaatggctt tagcctgctc aaccgcacac tggcacctgg ccaacagcat      420

ctcttcatga ttctgaagga caacgatctg cagctcagcc aagcatcagc catctatggc      480

ctaggatgca agaattcagc aatgttacct tc                                    512


<210> 4
<211> 1147
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
agactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaaagag agagagaaaa aggaagttag       60

aaaaacagcc ctagaggccc tacattctga gtaataggag ttccagaaag gaagtgattg      120

ctgcacaaca taaatttgaa aagaaagaga agtgagaaaa tagagggaag gaaatcaaag      180

aaataatcca acttctgaaa agtaaagaat gagcttccag cgggaaagtg cctgttgagt      240

gcaggcacag tggaggaaat gaagctgggt gtgttgccag gagttggaaa cttgtctgag      300

caacatagcg cgaccctgtg tctacaaaaa aataaaaaca aaacaaaaaa caaccaaaga      360

cttccgaaac agaatggctt tagcctgctc aaccgcacac tggcacctgg ccaacagcat      420

ctcttcatga ttctgaagga caacgatctg cagctcagcc aagcatcagc catctatggc      480

ctaggatgca agaattcagc aatgttacct tctgcatcac cgcgttgcgg cctcatcagt      540

cccacgactt tgtgcccatt ttactcatga ggagatggag gcccagagag ccagtcagaa      600

agtggctggg ccaggactaa gagtgcagcg cgctgcctcc gtgccctgcg tcaacagctc      660

aaggaactgg ggtgctccgg aaatggggcc aaggctgctg ggcagcagga cgctcagggc      720

cttggcctca ggagagcaaa ttccccactc ggagatcggt cttgttgctg cattttattc      780

atgggaaatc tgaggctaga agagacgaca aacgacacgc cgttggacac acggcaacgt      840

tttagatgtt gggtctggcc gggcggccgt caccggtcac catggggagg aggaggagcc      900

gagagacttg ctcgcggccg gggggaggca gaagcgcgtc ccgcgggaga ggtggctttg      960

aggagtgagc tcccggtccc gcggggacgc gagtgggccc agtgcccggg ctgccaggcg     1020

gggcggggcg gggccgggcg actgagaggg gcggggcctg gcggctggga ggggcggggc     1080

ggatgcgggg acagcggcct ggctaactcc tgcacggcag tgcccttccc ggagcgtgcc     1140

ctcgccg                                                               1147


<210> 5
<211> 386
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 5
taggtggctt cacccctctg cctgagcctg agtcctgtcc ctgccaagac tccgcccagc       60

cgacgcccac cccagctttc cctggactca tccctcagca gatatctgga tcctgcctag      120

cctggctcag catgactcat catgcagggt accgcccctg cccacctgtt ccccaatacc      180

gcaattcagg agctgggcag ttccccagag gccctaggaa actccccgcc cccgaccagg      240

ctttctccac tcctcccatc tgaccgcctg ttttctacgc ctcacgaccc tctgagcccc      300

ttggcgcact ccgacataac cacagccagg cctgagaagc cgccagcctc cgcagcgagt      360

gtgagcacgg gactcagaac tggctt                                           386


<210> 6
<211> 2355
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
agactctgtc tcaaaaaaaa aaaaaaaaaa aaaaaaagag agagagaaaa aggaagttag       60

aaaaacagcc ctagaggccc tacattctga gtaataggag ttccagaaag gaagtgattg      120

ctgcacaaca taaatttgaa aagaaagaga agtgagaaaa tagagggaag gaaatcaaag      180

aaataatcca acttctgaaa agtaaagaat gagcttccag cgggaaagtg cctgttgagt      240

gcaggcacag tggaggaaat gaagctgggt gtgttgccag gagttggaaa cttgtctgag      300

caacatagcg cgaccctgtg tctacaaaaa aataaaaaca aaacaaaaaa caaccaaaga      360

cttccgaaac agaatggctt tagcctgctc aaccgcacac tggcacctgg ccaacagcat      420

ctcttcatga ttctgaagga caacgatctg cagctcagcc aagcatcagc catctatggc      480

ctaggatgca agaattcagc aatgttacct tcgagtgcat caccgcgttg cggcctcatc      540

agtcccacga ctttgtgccc attttactca tgaggagatg gaggcccaga gagccagtca      600

gaaagtggct gggccaggac taagagtgca gcgcgctgcc tccgtgccct gcgtcaacag      660

ctcaaggaac tggggtgctc cggaaatggg gccaaggctg ctgggcagca ggacgctcag      720

ggccttggcc tcaggagagc aaattcccca ctcggagatc ggtcttgttg ctgcatttta      780

ttcatgggaa atctgaggct agaagagacg acaaacgaca cgccgttgga cacacggcaa      840

cgttttagat gttgggtctg gccgggcggc cgtcaccggt caccatgggg aggaggagga      900

gccgagagac ttgctcgcgg ccggggggag gcagaagcgc gtcccgcggg agaggtggct      960

ttgaggagtg agctcccggt cccgcgggga cgcgagtggg cccagtgccc gggctgccag     1020

gcggggcggg gcggggccgg gcgactgaga ggggcggggc ctggcggctg ggaggggcgg     1080

ggcggatgcg gggacagcgg cctggctaac tcctgcacgg cagtgccctt cccggagcgt     1140

gccctcgccg ctgcacagtg aggacgggac gcggaggggg cagcgggaac acgccgcccg     1200

catggctgcg acagttggca gcgccgcggg acagagggaa actgaggccg gagccgcaga     1260

ctggacaccc gagggggcga cccggggcag cacttggggc tcggctacgc gcacaggggg     1320

cggcgggcag cagagtctgg gcctccgcgg ccggggttcc accgccggcc gcctccggct     1380

cgcgcaacgg gagggaaaac ttggacaacc ctgccacgcc cagcccttgg ccgcgtggct     1440

tctcctgctc gaagcgcggt cccaggagtg gccgacgctc cctctcctgc ccattccgcg     1500

gatgggcaat cccaggcgga actcccttga gggtctcaga atatctggga gacctcgggc     1560

tcttgatctc cgagacaccc cgtttcgtag tggagaacag tccagatcgg ggaagtttat     1620

tttgcccaaa gccgcataga ggccccctgg ccctcgattc cctctgcggg gctcagcagc     1680

gttgcagcct agacgggtct tactgtgagc cgagcagcct ctgggaccac agaccttccc     1740

ctaccccaac gttagaagcc ggagcccagc aaggagaagc gcgcacctcc tgctgtgaac     1800

gcgcacgacg ccagggcagc tgccagaggc catggcctgg cgtgggcctg gagcccctct     1860

ggccagcctg cacggggcca gggctacggg ataccagcag cgtgccctgg gctggatggc     1920

aggagagaca ggacttgagg ctgtcccaga atgggctcag gcagggcgag gatatcaggg     1980

gaggtggtgt acaggaagca gccgcccagc ttgcctggca cacagcaagc cctgcccatg     2040

aaggcctact gccagaacag tgggcgaggc ccggcgtctc tgtggagtcg gtggggcccg     2100

ggacagggca gcctgaggca ggtttccact ggcggtgaaa ggggccgtgt ggcaaggaca     2160

ggagagccag cctcagccca gcaggggaag gcggcccctg agtctccacc tggctgctgg     2220

cagccccact cggagcatcg gcgaaactga ggcttgccaa agaagccttt gtccagagtc     2280

acgcagctgg cgcggtggag ccagggccag aacccgtgca ggctgatccc agcctgcctt     2340

ctccactgtg ccccg                                                      2355


<210> 7
<211> 1021
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 7
taggtggctt cacccctctg cctgagcctg agtcctgtcc ctgccaagac tccgcccagc       60

cgacgcccac cccagctttc cctggactca tccctcagca gatatctgga tcctgcctag      120

cctggctcag catgactcat catgcagggt accgcccctg cccacctgtt ccccaatacc      180

gcaattcagg agctgggcag ttccccagag gccctaggaa actccccgcc cccgaccagg      240

ctttctccac tcctcccatc tgaccgcctg ttttctacgc ctcacgaccc tctgagcccc      300

ttggcgcact ccgacataac cacagccagg cctgagaagc cgccagcctc cgcagcgagt      360

gtgagcacgg gactcagaac tggctttgca tcaccgcgtt gcggcctcat cagtcccacg      420

actttgtgcc cattttactc atgaggagat ggaggcccag agagccagtc agaaagtggc      480

tgggccagga ctaagagtgc agcgcgctgc ctccgtgccc tgcgtcaaca gctcaaggaa      540

ctggggtgct ccggaaatgg ggccaaggct gctgggcagc aggacgctca gggccttggc      600

ctcaggagag caaattcccc actcggagat cggtcttgtt gctgcatttt attcatggga      660

aatctgaggc tagaagagac gacaaacgac acgccgttgg acacacggca acgttttaga      720

tgttgggtct ggccgggcgg ccgtcaccgg tcaccatggg gaggaggagg agccgagaga      780

cttgctcgcg gccgggggga ggcagaagcg cgtcccgcgg gagaggtggc tttgaggagt      840

gagctcccgg tcccgcgggg acgcgagtgg gcccagtgcc cgggctgcca ggcggggcgg      900

ggcggggccg ggcgactgag aggggcgggg cctggcggct gggaggggcg gggcggatgc      960

ggggacagcg gcctggctaa ctcctgcacg gcagtgccct tcccggagcg tgccctcgcc     1020

g                                                                     1021


<210> 8
<211> 2229
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
taggtggctt cacccctctg cctgagcctg agtcctgtcc ctgccaagac tccgcccagc       60

cgacgcccac cccagctttc cctggactca tccctcagca gatatctgga tcctgcctag      120

cctggctcag catgactcat catgcagggt accgcccctg cccacctgtt ccccaatacc      180

gcaattcagg agctgggcag ttccccagag gccctaggaa actccccgcc cccgaccagg      240

ctttctccac tcctcccatc tgaccgcctg ttttctacgc ctcacgaccc tctgagcccc      300

ttggcgcact ccgacataac cacagccagg cctgagaagc cgccagcctc cgcagcgagt      360

gtgagcacgg gactcagaac tggcttgagt gcatcaccgc gttgcggcct catcagtccc      420

acgactttgt gcccatttta ctcatgagga gatggaggcc cagagagcca gtcagaaagt      480

ggctgggcca ggactaagag tgcagcgcgc tgcctccgtg ccctgcgtca acagctcaag      540

gaactggggt gctccggaaa tggggccaag gctgctgggc agcaggacgc tcagggcctt      600

ggcctcagga gagcaaattc cccactcgga gatcggtctt gttgctgcat tttattcatg      660

ggaaatctga ggctagaaga gacgacaaac gacacgccgt tggacacacg gcaacgtttt      720

agatgttggg tctggccggg cggccgtcac cggtcaccat ggggaggagg aggagccgag      780

agacttgctc gcggccgggg ggaggcagaa gcgcgtcccg cgggagaggt ggctttgagg      840

agtgagctcc cggtcccgcg gggacgcgag tgggcccagt gcccgggctg ccaggcgggg      900

cggggcgggg ccgggcgact gagaggggcg gggcctggcg gctgggaggg gcggggcgga      960

tgcggggaca gcggcctggc taactcctgc acggcagtgc ccttcccgga gcgtgccctc     1020

gccgctgcac agtgaggacg ggacgcggag ggggcagcgg gaacacgccg cccgcatggc     1080

tgcgacagtt ggcagcgccg cgggacagag ggaaactgag gccggagccg cagactggac     1140

acccgagggg gcgacccggg gcagcacttg gggctcggct acgcgcacag ggggcggcgg     1200

gcagcagagt ctgggcctcc gcggccgggg ttccaccgcc ggccgcctcc ggctcgcgca     1260

acgggaggga aaacttggac aaccctgcca cgcccagccc ttggccgcgt ggcttctcct     1320

gctcgaagcg cggtcccagg agtggccgac gctccctctc ctgcccattc cgcggatggg     1380

caatcccagg cggaactccc ttgagggtct cagaatatct gggagacctc gggctcttga     1440

tctccgagac accccgtttc gtagtggaga acagtccaga tcggggaagt ttattttgcc     1500

caaagccgca tagaggcccc ctggccctcg attccctctg cggggctcag cagcgttgca     1560

gcctagacgg gtcttactgt gagccgagca gcctctggga ccacagacct tcccctaccc     1620

caacgttaga agccggagcc cagcaaggag aagcgcgcac ctcctgctgt gaacgcgcac     1680

gacgccaggg cagctgccag aggccatggc ctggcgtggg cctggagccc ctctggccag     1740

cctgcacggg gccagggcta cgggatacca gcagcgtgcc ctgggctgga tggcaggaga     1800

gacaggactt gaggctgtcc cagaatgggc tcaggcaggg cgaggatatc aggggaggtg     1860

gtgtacagga agcagccgcc cagcttgcct ggcacacagc aagccctgcc catgaaggcc     1920

tactgccaga acagtgggcg aggcccggcg tctctgtgga gtcggtgggg cccgggacag     1980

ggcagcctga ggcaggtttc cactggcggt gaaaggggcc gtgtggcaag gacaggagag     2040

ccagcctcag cccagcaggg gaaggcggcc cctgagtctc cacctggctg ctggcagccc     2100

cactcggagc atcggcgaaa ctgaggcttg ccaaagaagc ctttgtccag agtcacgcag     2160

ctggcgcggt ggagccaggg ccagaacccg tgcaggctga tcccagcctg ccttctccac     2220

tgtgccccg                                                             2229


<210> 9
<211> 62
<212> PRT
<213> Homo sapiens

<400> 9
Met Asp Pro Asn Cys Ser Cys Ala Ala Ala Gly Val Ser Cys Thr Cys 
1               5                   10                  15      


Ala Ser Ser Cys Lys Cys Lys Glu Cys Lys Cys Thr Ser Cys Lys Lys 
            20                  25                  30          


Ser Cys Cys Ser Cys Cys Pro Val Gly Cys Ala Lys Cys Ala Gln Gly 
        35                  40                  45              


Cys Ile Cys Lys Gly Ala Ser Glu Lys Cys Ser Cys Cys Ala 
    50                  55                  60          


<210> 10
<211> 420
<212> DNA
<213> Homo sapiens

<400> 10
actccgcctt ccacgtgcac ccactgcctc ttcccttctc gcttgggaac tctagtctcg       60

cctcgggttg caatggaccc caactgctcc tgtgccgctg gtgtctcctg cacctgcgcc      120

agctcctgca agtgcaaaga gtgcaaatgc acctcctgca agaagagctg ctgctcctgc      180

tgccctgtgg gctgtgccaa gtgtgcccag ggctgcatct gcaaaggggc atcggagaag      240

tgcagctgct gcgcctgatg tcgggacagc cctgctccca agtacaaata gagtgacccg      300

taaaatccag gattttttgt tttttgctac aatcttgacc cctttgctac attccttttt      360

ttctgtgaaa tatgtgaata ataattaaac acttagactt gaaaaaaaaa aaaaaaaaaa      420


<210> 11
<211> 2025
<212> DNA
<213> Homo sapiens

<400> 11
gcaacctcca ccttccggtt tcaagcgatt ctcctgcctc agcctcccaa gtagttggga       60

ttacaggcac ccgccaccac gcctggctaa tttttatatt tttagtaaag acagggtttc      120

accattttgg ccaggctggt cttgaacccc tgatctcgtg atccacccac gttggcctcc      180

caaagtgctg gaattacagg cgtgagccac catgcctggc ccacattaca ttcttactca      240

cctcccccta ccatggaatt ttattccaca gatatgctat tggtttagct actatatgta      300

tatctgtgtt ttatacataa agcacaagaa ccttccagaa ccaattttcg ccaccttgga      360

agtaatacca cctctactaa gaatgcacag catagaccat aaaacctcaa tgctaagttc      420

aaatattggc cctaccacac atgagctgtg tggtcttgta caagttacat aacttctcct      480

ccttgtctca aactcctcac atataagatg aggataataa tagtacctgc ggccacacac      540

agtggcttaa acgtgtaatc ccagcacttt gggaggctgc ggcagaagga tcactcaaac      600

tcaggagttc aagagcagcc tgggtacatg gcgaaactct gtctctacaa aaaatacaaa      660

aattagctgg gtgtggtgat gtgtgcctgt agttccagct acttgggagg ctgaggtgag      720

aggatcgttc gagcccagga gatcaaggat gcagtgagct atgatcatgt ggctgcactc      780

cagcctggat aacagagcca gaccctgtct gaaagaaaca aaaacaaaaa cattagcacc      840

tgcatcatag ggtcactggg ggcactacat gagttcatgt acatcgagga cttaggacat      900

tgcctcaggc agacctagtg ctgcacaatt gcttatgtaa ttattcccaa atttctccag      960

ggcccacaga agaacatgga agtatcttgg tttggcaatt aaggtgaatc acattctcac     1020

tctccttttc tgcatctcta ccccacattc ccacaaagct ttattcacac caagtctcca     1080

gtccttgcct gcattgtgtg atgggtgcct gcagtgatgg gtggggacac ccatcactgt     1140

ccagggcgtc cccaccatcc tcacagcctc tctgtctggc ctcctgcctt tgagccagcc     1200

caccacactc tcatttctct gcccagcaga aaccaaactg tcctctgcat ttactgtctc     1260

aactggaaga gaaatgcaga atgacaaaga acttgtgaac aagggtcagc tccaacagag     1320

agtgaagcca aaggggctgg gcagaaagag agatgaagac gggggtctga ggaataaggc     1380

tgtaccagag tgagagtacg ggggaggggt tgaacaagag ttcagggagg agagaattcc     1440

cagcgctgag ccagagactc ctttacagag gcccaaggag gcgtggaggg agggggaagg     1500

ctgccaaggc tctttctgtc tccatgagtg tgtcaagaat gcaaagcact aatgctcttc     1560

acttggtcca tcttgcaggg ttgagtttgc agtgagcaac cttgaaggat gagctgacat     1620

ctcgctcagg gccaaataac cgacttgctt actgcttgct ataaaatggc acgttaccca     1680

aggtcagagt tcccttccta taacctcccc atccctcaca cattcacagg tatctatcca     1740

agccatggca tcactctgtg gggcttgggg gcaaggcaac tgacactgca cgctggttct     1800

catgcttgcc aagcatgaag ccctgtgctg ctagcagctg tggaacatag ccgttagctt     1860

taaaagaggg taaaatcacg tcctggacag gacagccagg tgagttggga agggaagaga     1920

gcctgccacg ggcacaggca tgttggggga agtggaagtg gtgagagcac agtaggaagt     1980

gagaaggggc gggccgtgct taccaggccg tggacttaaa ccagg                     2025


<210> 12
<211> 635
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
tgcatcaccg cgttgcggcc tcatcagtcc cacgactttg tgcccatttt actcatgagg       60

agatggaggc ccagagagcc agtcagaaag tggctgggcc aggactaaga gtgcagcgcg      120

ctgcctccgt gccctgcgtc aacagctcaa ggaactgggg tgctccggaa atggggccaa      180

ggctgctggg cagcaggacg ctcagggcct tggcctcagg agagcaaatt ccccactcgg      240

agatcggtct tgttgctgca ttttattcat gggaaatctg aggctagaag agacgacaaa      300

cgacacgccg ttggacacac ggcaacgttt tagatgttgg gtctggccgg gcggccgtca      360

ccggtcacca tggggaggag gaggagccga gagacttgct cgcggccggg gggaggcaga      420

agcgcgtccc gcgggagagg tggctttgag gagtgagctc ccggtcccgc ggggacgcga      480

gtgggcccag tgcccgggct gccaggcggg gcggggcggg gccgggcgac tgagaggggc      540

ggggcctggc ggctgggagg ggcggggcgg atgcggggac agcggcctgg ctaactcctg      600

cacggcagtg cccttcccgg agcgtgccct cgccg                                 635


<210> 13
<211> 1205
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 13
ctgcacagtg aggacgggac gcggaggggg cagcgggaac acgccgcccg catggctgcg       60

acagttggca gcgccgcggg acagagggaa actgaggccg gagccgcaga ctggacaccc      120

gagggggcga cccggggcag cacttggggc tcggctacgc gcacaggggg cggcgggcag      180

cagagtctgg gcctccgcgg ccggggttcc accgccggcc gcctccggct cgcgcaacgg      240

gagggaaaac ttggacaacc ctgccacgcc cagcccttgg ccgcgtggct tctcctgctc      300

gaagcgcggt cccaggagtg gccgacgctc cctctcctgc ccattccgcg gatgggcaat      360

cccaggcgga actcccttga gggtctcaga atatctggga gacctcgggc tcttgatctc      420

cgagacaccc cgtttcgtag tggagaacag tccagatcgg ggaagtttat tttgcccaaa      480

gccgcataga ggccccctgg ccctcgattc cctctgcggg gctcagcagc gttgcagcct      540

agacgggtct tactgtgagc cgagcagcct ctgggaccac agaccttccc ctaccccaac      600

gttagaagcc ggagcccagc aaggagaagc gcgcacctcc tgctgtgaac gcgcacgacg      660

ccagggcagc tgccagaggc catggcctgg cgtgggcctg gagcccctct ggccagcctg      720

cacggggcca gggctacggg ataccagcag cgtgccctgg gctggatggc aggagagaca      780

ggacttgagg ctgtcccaga atgggctcag gcagggcgag gatatcaggg gaggtggtgt      840

acaggaagca gccgcccagc ttgcctggca cacagcaagc cctgcccatg aaggcctact      900

gccagaacag tgggcgaggc ccggcgtctc tgtggagtcg gtggggcccg ggacagggca      960

gcctgaggca ggtttccact ggcggtgaaa ggggccgtgt ggcaaggaca ggagagccag     1020

cctcagccca gcaggggaag gcggcccctg agtctccacc tggctgctgg cagccccact     1080

cggagcatcg gcgaaactga ggcttgccaa agaagccttt gtccagagtc acgcagctgg     1140

cgcggtggag ccagggccag aacccgtgca ggctgatccc agcctgcctt ctccactgtg     1200

ccccg                                                                 1205


<210> 14
<211> 1843
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gagtgcatca ccgcgttgcg gcctcatcag tcccacgact ttgtgcccat tttactcatg       60

aggagatgga ggcccagaga gccagtcaga aagtggctgg gccaggacta agagtgcagc      120

gcgctgcctc cgtgccctgc gtcaacagct caaggaactg gggtgctccg gaaatggggc      180

caaggctgct gggcagcagg acgctcaggg ccttggcctc aggagagcaa attccccact      240

cggagatcgg tcttgttgct gcattttatt catgggaaat ctgaggctag aagagacgac      300

aaacgacacg ccgttggaca cacggcaacg ttttagatgt tgggtctggc cgggcggccg      360

tcaccggtca ccatggggag gaggaggagc cgagagactt gctcgcggcc ggggggaggc      420

agaagcgcgt cccgcgggag aggtggcttt gaggagtgag ctcccggtcc cgcggggacg      480

cgagtgggcc cagtgcccgg gctgccaggc ggggcggggc ggggccgggc gactgagagg      540

ggcggggcct ggcggctggg aggggcgggg cggatgcggg gacagcggcc tggctaactc      600

ctgcacggca gtgcccttcc cggagcgtgc cctcgccgct gcacagtgag gacgggacgc      660

ggagggggca gcgggaacac gccgcccgca tggctgcgac agttggcagc gccgcgggac      720

agagggaaac tgaggccgga gccgcagact ggacacccga gggggcgacc cggggcagca      780

cttggggctc ggctacgcgc acagggggcg gcgggcagca gagtctgggc ctccgcggcc      840

ggggttccac cgccggccgc ctccggctcg cgcaacggga gggaaaactt ggacaaccct      900

gccacgccca gcccttggcc gcgtggcttc tcctgctcga agcgcggtcc caggagtggc      960

cgacgctccc tctcctgccc attccgcgga tgggcaatcc caggcggaac tcccttgagg     1020

gtctcagaat atctgggaga cctcgggctc ttgatctccg agacaccccg tttcgtagtg     1080

gagaacagtc cagatcgggg aagtttattt tgcccaaagc cgcatagagg ccccctggcc     1140

ctcgattccc tctgcggggc tcagcagcgt tgcagcctag acgggtctta ctgtgagccg     1200

agcagcctct gggaccacag accttcccct accccaacgt tagaagccgg agcccagcaa     1260

ggagaagcgc gcacctcctg ctgtgaacgc gcacgacgcc agggcagctg ccagaggcca     1320

tggcctggcg tgggcctgga gcccctctgg ccagcctgca cggggccagg gctacgggat     1380

accagcagcg tgccctgggc tggatggcag gagagacagg acttgaggct gtcccagaat     1440

gggctcaggc agggcgagga tatcagggga ggtggtgtac aggaagcagc cgcccagctt     1500

gcctggcaca cagcaagccc tgcccatgaa ggcctactgc cagaacagtg ggcgaggccc     1560

ggcgtctctg tggagtcggt ggggcccggg acagggcagc ctgaggcagg tttccactgg     1620

cggtgaaagg ggccgtgtgg caaggacagg agagccagcc tcagcccagc aggggaaggc     1680

ggcccctgag tctccacctg gctgctggca gccccactcg gagcatcggc gaaactgagg     1740

cttgccaaag aagcctttgt ccagagtcac gcagctggcg cggtggagcc agggccagaa     1800

cccgtgcagg ctgatcccag cctgccttct ccactgtgcc ccg                       1843


<210> 15
<211> 1846
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 15
ctgcacagtg aggacgggac gcggaggggg cagcgggaac acgccgcccg catggctgcg       60

acagttggca gcgccgcggg acagagggaa actgaggccg gagccgcaga ctggacaccc      120

gagggggcga cccggggcag cacttggggc tcggctacgc gcacaggggg cggcgggcag      180

cagagtctgg gcctccgcgg ccggggttcc accgccggcc gcctccggct cgcgcaacgg      240

gagggaaaac ttggacaacc ctgccacgcc cagcccttgg ccgcgtggct tctcctgctc      300

gaagcgcggt cccaggagtg gccgacgctc cctctcctgc ccattccgcg gatgggcaat      360

cccaggcgga actcccttga gggtctcaga atatctggga gacctcgggc tcttgatctc      420

cgagacaccc cgtttcgtag tggagaacag tccagatcgg ggaagtttat tttgcccaaa      480

gccgcataga ggccccctgg ccctcgattc cctctgcggg gctcagcagc gttgcagcct      540

agacgggtct tactgtgagc cgagcagcct ctgggaccac agaccttccc ctaccccaac      600

gttagaagcc ggagcccagc aaggagaagc gcgcacctcc tgctgtgaac gcgcacgacg      660

ccagggcagc tgccagaggc catggcctgg cgtgggcctg gagcccctct ggccagcctg      720

cacggggcca gggctacggg ataccagcag cgtgccctgg gctggatggc aggagagaca      780

ggacttgagg ctgtcccaga atgggctcag gcagggcgag gatatcaggg gaggtggtgt      840

acaggaagca gccgcccagc ttgcctggca cacagcaagc cctgcccatg aaggcctact      900

gccagaacag tgggcgaggc ccggcgtctc tgtggagtcg gtggggcccg ggacagggca      960

gcctgaggca ggtttccact ggcggtgaaa ggggccgtgt ggcaaggaca ggagagccag     1020

cctcagccca gcaggggaag gcggcccctg agtctccacc tggctgctgg cagccccact     1080

cggagcatcg gcgaaactga ggcttgccaa agaagccttt gtccagagtc acgcagctgg     1140

cgcggtggag ccagggccag aacccgtgca ggctgatccc agcctgcctt ctccactgtg     1200

ccccgtgcat caccgcgttg cggcctcatc agtcccacga ctttgtgccc attttactca     1260

tgaggagatg gaggcccaga gagccagtca gaaagtggct gggccaggac taagagtgca     1320

gcgcgctgcc tccgtgccct gcgtcaacag ctcaaggaac tggggtgctc cggaaatggg     1380

gccaaggctg ctgggcagca ggacgctcag ggccttggcc tcaggagagc aaattcccca     1440

ctcggagatc ggtcttgttg ctgcatttta ttcatgggaa atctgaggct agaagagacg     1500

acaaacgaca cgccgttgga cacacggcaa cgttttagat gttgggtctg gccgggcggc     1560

cgtcaccggt caccatgggg aggaggagga gccgagagac ttgctcgcgg ccggggggag     1620

gcagaagcgc gtcccgcggg agaggtggct ttgaggagtg agctcccggt cccgcgggga     1680

cgcgagtggg cccagtgccc gggctgccag gcggggcggg gcggggccgg gcgactgaga     1740

ggggcggggc ctggcggctg ggaggggcgg ggcggatgcg gggacagcgg cctggctaac     1800

tcctgcacgg cagtgccctt cccggagcgt gccctcgccg ggatcc                    1846


<210> 16
<211> 1591
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 16
taggtggctt cacccctctg cctgagcctg agtcctgtcc ctgccaagac tccgcccagc       60

cgacgcccac cccagctttc cctggactca tccctcagca gatatctgga tcctgcctag      120

cctggctcag catgactcat catgcagggt accgcccctg cccacctgtt ccccaatacc      180

gcaattcagg agctgggcag ttccccagag gccctaggaa actccccgcc cccgaccagg      240

ctttctccac tcctcccatc tgaccgcctg ttttctacgc ctcacgaccc tctgagcccc      300

ttggcgcact ccgacataac cacagccagg cctgagaagc cgccagcctc cgcagcgagt      360

gtgagcacgg gactcagaac tggcttctgc acagtgagga cgggacgcgg agggggcagc      420

gggaacacgc cgcccgcatg gctgcgacag ttggcagcgc cgcgggacag agggaaactg      480

aggccggagc cgcagactgg acacccgagg gggcgacccg gggcagcact tggggctcgg      540

ctacgcgcac agggggcggc gggcagcaga gtctgggcct ccgcggccgg ggttccaccg      600

ccggccgcct ccggctcgcg caacgggagg gaaaacttgg acaaccctgc cacgcccagc      660

ccttggccgc gtggcttctc ctgctcgaag cgcggtccca ggagtggccg acgctccctc      720

tcctgcccat tccgcggatg ggcaatccca ggcggaactc ccttgagggt ctcagaatat      780

ctgggagacc tcgggctctt gatctccgag acaccccgtt tcgtagtgga gaacagtcca      840

gatcggggaa gtttattttg cccaaagccg catagaggcc ccctggccct cgattccctc      900

tgcggggctc agcagcgttg cagcctagac gggtcttact gtgagccgag cagcctctgg      960

gaccacagac cttcccctac cccaacgtta gaagccggag cccagcaagg agaagcgcgc     1020

acctcctgct gtgaacgcgc acgacgccag ggcagctgcc agaggccatg gcctggcgtg     1080

ggcctggagc ccctctggcc agcctgcacg gggccagggc tacgggatac cagcagcgtg     1140

ccctgggctg gatggcagga gagacaggac ttgaggctgt cccagaatgg gctcaggcag     1200

ggcgaggata tcaggggagg tggtgtacag gaagcagccg cccagcttgc ctggcacaca     1260

gcaagccctg cccatgaagg cctactgcca gaacagtggg cgaggcccgg cgtctctgtg     1320

gagtcggtgg ggcccgggac agggcagcct gaggcaggtt tccactggcg gtgaaagggg     1380

ccgtgtggca aggacaggag agccagcctc agcccagcag gggaaggcgg cccctgagtc     1440

tccacctggc tgctggcagc cccactcgga gcatcggcga aactgaggct tgccaaagaa     1500

gcctttgtcc agagtcacgc agctggcgcg gtggagccag ggccagaacc cgtgcaggct     1560

gatcccagcc tgccttctcc actgtgcccc g                                    1591


<210> 17
<211> 230
<212> PRT
<213> Homo sapiens

<400> 17
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Thr Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


<210> 18
<211> 770
<212> DNA
<213> Homo sapiens

<400> 18
tcttttctgc agttcaaggg aaagacgaga tcttgcacaa ggcactctgc ttctgccctt       60

ggctggggaa gggtggcatg gagcctctcc ggctgctcat cttactcttt gtcacagagc      120

tgtccggagc ccacaacacc acagtgttcc agggcgtggc gggccagtcc ctgcaggtgt      180

cttgccccta tgactccatg aagcactggg ggaggcgcaa ggcctggtgc cgccagctgg      240

gagagaaggg cccatgccag cgtgtggtca gcacgcacaa cttgtggctg ctgtccttcc      300

tgaggaggtg gaatgggagc acagccatca cagacgatac cctgggtggc actctcacca      360

ttacgctgcg gaatctacaa ccccatgatg cgggtctcta ccagtgccag agcctccatg      420

gcagtgaggc tgacaccctc aggaaggtcc tggtggaggt gctggcagac cccctggatc      480

accgggatgc tggagatctc tggttccccg gggagtctga gagcttcgag gatgcccatg      540

tggagcacag catctccagg agcctcttgg aaggagaaat ccccttccca cccacttcca      600

tccttctcct cctggcctgc atctttctca tcaagattct agcagccagc gccctctggg      660

ctgcagcctg gcatggacag aagccaggga cacatccacc cagtgaactg gactgtggcc      720

atgacccagg gtatcagctc caaactctgc cagggctgag agacacgtga                 770


<210> 19
<211> 230
<212> PRT
<213> Homo sapiens

<400> 19
Met Glu Pro Leu Arg Leu Leu Ile Leu Leu Phe Val Thr Glu Leu Ser 
1               5                   10                  15      


Gly Ala His Asn Thr Thr Val Phe Gln Gly Val Ala Gly Gln Ser Leu 
            20                  25                  30          


Gln Val Ser Cys Pro Tyr Asp Ser Met Lys His Trp Gly Arg Arg Lys 
        35                  40                  45              


Ala Trp Cys Arg Gln Leu Gly Glu Lys Gly Pro Cys Gln Arg Val Val 
    50                  55                  60                  


Ser Thr His Asn Leu Trp Leu Leu Ser Phe Leu Arg Arg Trp Asn Gly 
65                  70                  75                  80  


Ser Thr Ala Ile Lys Asp Asp Thr Leu Gly Gly Thr Leu Thr Ile Thr 
                85                  90                  95      


Leu Arg Asn Leu Gln Pro His Asp Ala Gly Leu Tyr Gln Cys Gln Ser 
            100                 105                 110         


Leu His Gly Ser Glu Ala Asp Thr Leu Arg Lys Val Leu Val Glu Val 
        115                 120                 125             


Leu Ala Asp Pro Leu Asp His Arg Asp Ala Gly Asp Leu Trp Phe Pro 
    130                 135                 140                 


Gly Glu Ser Glu Ser Phe Glu Asp Ala His Val Glu His Ser Ile Ser 
145                 150                 155                 160 


Arg Ser Leu Leu Glu Gly Glu Ile Pro Phe Pro Pro Thr Ser Ile Leu 
                165                 170                 175     


Leu Leu Leu Ala Cys Ile Phe Leu Ile Lys Ile Leu Ala Ala Ser Ala 
            180                 185                 190         


Leu Trp Ala Ala Ala Trp His Gly Gln Lys Pro Gly Thr His Pro Pro 
        195                 200                 205             


Ser Glu Leu Asp Cys Gly His Asp Pro Gly Tyr Gln Leu Gln Thr Leu 
    210                 215                 220                 


Pro Gly Leu Arg Asp Thr 
225                 230 


