                         SEQUENCE LISTING

<110>  The University of Pennsylvania
       Siegel, Donald L
       Bhoj, Vijay
       Rader, Christoph
       Goydel, Rebecca
 
<120>  Humanized Anti-GDNF Family Alpha-Receptor 4 (GFR-alpha-4) 
       Antibodies and Chimeric Antigen Receptors (CARs)

<130>  046483-7262WO1(02356)

<150>  U.S. Provisional Patent No. 62/907,909
<151>  2019-09-30

<160>  169   

<170>  PatentIn version 3.5

<210>  1
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  Rabbit P4-10 heavy chain variable region

<400>  1
cagtccgtga aggagagcga gggcggcctg ttcaagccca ccgacaccct gaccctgacc       60

tgcacagtga gcggcttcag cctgtccaga cacgccctga catgggtgag acaggcccct      120

ggcaacggcc tggaatggat cggcgccatc gacaacgccg gcaccaccta ctacgccagc      180

tgggccaagt ccaggtccac catcaccagg aacaccgacc tccacaccgt gaccctgaag      240

atgacaagcc tgaccgcctc cgacaccgcc acctacttct gcgccagggt gttctacgac      300

atcaacagcg gctactacct ggatggcatg gacctgtggg gacctggcac actggtgacc      360

gtgagcagc                                                              369


<210>  2
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1

<400>  2
caagttcagc tgcaagaaag cggacccggt ttagtcaagc ccagcgagac tttatcttta       60

acatgcgccg tgagcggcta ctccatctct cgtcacgctt taacatggat taggcagccc      120

cccggtaagg gtttagaatg gatcggcgcc atcgacaacg ctggcaccac ctactacgcc      180

tcttgggcta agtctcgtgt gacaatcagc gtggacacct ccaagaacca gttttcttta      240

aagctgagca gcgtgaccgc tgccgacacc gctgtgtact attgcgctcg tgtcttctac      300

gacatcaaca gcggctacta tttagatggc atggatttat ggggacccgg tactttagtg      360

accgtgagct cc                                                          372


<210>  3
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1m1

<400>  3
cagcagagcg tgaaggagag cggccccggt ctggtgaagc ccagcgagac tttatcttta       60

acatgcgccg tgagcggctt ctctttatct cgtcacgctt taacttgggt gagacagcct      120

cccggtaaag gtttagagtg gatcggcgcc atcgacaacg ccggcacaac ctactacgcc      180

agctgggcca agtctcgtgt gaccatctct cgtaacaccg atttacacac cgtgtcttta      240

aagctgagct ccgtgaccgc tgccgatacc gccgtgtact tctgcgctag ggtgttctac      300

gacatcaaca gcggctacta tttagatggc atggatctgt ggggccccgg cacactggtc      360

acagtgtcca gc                                                          372


<210>  4
<211>  372
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2

<400>  4
gaggtgcagc tggtggaaag cggcggagga ctggtgcagc ccggtggctc tttaagactg       60

agctgtgctg ccagcggctt cacattctct cgtcacgctt taacttgggt gagacaagct      120

cccggaaagg gtttagaatg ggtgagcgcc atcgacaacg ccggaaccac ctactacgcc      180

agctgggcca agtctcgttt caccatctct cgtgataacg ccaagaacag cctctattta      240

cagatgaact ctttaagggc cgaggacacc gccgtgtact actgcgctag ggtgttctac      300

gacatcaaca gcggctacta tctggacggc atggatttat ggggccccgg tacactggtc      360

accgtgagca gc                                                          372


<210>  5
<211>  369
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2m1

<400>  5
cagagcgtca aggagtccgg aggaggactg gtgcagcccg gtggctcttt aaggctgagc       60

tgtgccgcct ctggctttac tttatctcgt cacgctttaa catgggtgag acaagctccc      120

ggtaagggac tggagtggat cggcgccatc gacaacgccg gcaccaccta ctacgcctct      180

tgggccaagt ctcgtttcac catctctcgt aacaccgatt tacacaccgt gtatttacag      240

atgaactctt taagggccga ggacacagcc gtctatttct gcgctcgtgt gttctacgac      300

atcaatagcg gctactacct cgacggaatg gatctgtggg gccccggtac tttagtgaca      360

gtcagcagc                                                              369


<210>  6
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  Rabbit P4-10 heavy chain variable region

<400>  6

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg His Ala 
            20                  25                  30          


Leu Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  7
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1

<400>  7

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1m1

<400>  8

Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  9
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2

<400>  9

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  10
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2m1

<400>  10

Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
1               5                   10                  15      


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Arg His Ala 
            20                  25                  30          


Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val Tyr Leu Gln 
65                  70                  75                  80  


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 
                85                  90                  95      


Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp Leu 
            100                 105                 110         


Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  11
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  Rabbit P4-10 light chain variable region

<400>  11
cagttcgtgc tgacacagag ccctagcgtg agcgccgccc tgggagcctc cgctaaactg       60

acctgcaccc tgagcagcgc ccacaagacc tacaccatcg actggtacca acagcagcag      120

ggcgaggccc ccaggtatct gatgcaggtg aagtccgacg gcagctacac caaaggcacc      180

ggcgtgcctg acaggttcag cggcagctcc agcggagccg acaggtacct gatcatcccc      240

tccgtgcagg ccgacgacga ggctggctac gtgtgtggcg ccgacgacaa tggcggctac      300

gtgttcggag gcggcaccca gctgaccgtg aca                                   333


<210>  12
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1

<400>  12
cagctggtgc tgacccagag ccccagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt taagcagcgc ccacaagacc tacacaatcg cttggcacca gcagcagccc      120

gaaaagggcc ccagatatct gatgaaggtc aagtccgacg gcagctactc caagggcgac      180

ggcatccccg atcgtttcag cggttcttcc agcggcgccg agaggtattt aaccatcagc      240

tctttacaga gcgaggacga ggccgactac tactgcggcg ctgacgacaa cggcggctac      300

gtctttggcg gcggcacaaa actgaccgtg ctg                                   333


<210>  13
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m1

<400>  13
cagtttgtgc tgacccagag ccctagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt tatcctccgc ccacaagacc tacaccatcg actggtacca gcagcagccc      120

gaaaagggcc ctcgttatct gatgcaagtt aagtccgacg gcagctacac caagggaacc      180

ggcgtgcccg acagattctc cggtagcagc agcggcgccg acagatattt aaccatcagc      240

tctttacagt ccgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggag gcggcacaca gctgaccgtg act                                   333


<210>  14
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m2

<400>  14
cagtttgtgc tgacccagag ccctagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt tatcctccgc ccacaagacc tacaccatcg actggcacca gcagcagccc      120

gaaaagggcc ctcgttatct gatgcaagtt aagtccgacg gcagctacac caagggaacc      180

ggcatccccg acagattctc cggtagcagc agcggcgccg agagatattt aaccatcagc      240

tctttacagt ccgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggag gcggcacaca gctgaccgtg ctg                                   333


<210>  15
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m3

<400>  15
cagctggtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg actggtacca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcgtgcccg acagattcag cggcagctcc agcggagccg atcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctg                                   333


<210>  16
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m4

<400>  16
cagttggtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg cctggcatca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcgtgcccg acagattcag cggcagctcc agcggagccg atcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctc                                   333


<210>  17
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2

<400>  17
cagagcgtgc tgacacagcc tcctagcgcc agcggcacac ccggtcagag agtgaccatc       60

agctgctccg gcagcagcgc ccacaagacc tacaccgtga actggtacca gcagctgccc      120

ggcacagccc ctaagctgct gatctacgtg aaatccgacg gcagctacca gaggcctagc      180

ggagtgcccg atcgtttcag cggcagcaaa agcggcacaa gcgcctcttt agctatcagc      240

ggtttacaga gcgaggacga ggccgactat tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggaaccaa gctgacagtg ctg                                   333


<210>  18
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m1

<400>  18
cagttcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagctcc agcggcgccg ataggtattt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg acc                                   333


<210>  19
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m2

<400>  19
cagttcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagctcc agcggcgccg atgccagctt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg ctg                                   333


<210>  20
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m3

<400>  20
cagagcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagcaag agcggcacca gcgccagctt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg ctg                                   333


<210>  21
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3

<400>  21
cagtccgctt taacacagcc cgcttctgtg tccggaagcc ccggtcagag catcaccatc       60

agctgcaccg gcaccagcgc tcacaagacc tacaccgtga gctggtacca gcagcacccc      120

ggtaaggccc ccaaactgat gatctacgtg aagagcgacg gcagctacaa cagacccagc      180

ggcgtgagca atcgtttcag cggcagcaag agcggcaaca ccgcttcttt aaccatcagc      240

ggtttacaag ctgaagacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgtttggcg gcggcaccaa actgaccgtg ctg                                   333


<210>  22
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m1

<400>  22
cagttcgtgc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagtattt aatgcaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat gtgtgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg act                                   333


<210>  23
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m2

<400>  23
cagttcgtgc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagctgat gatccaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgagca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg ctg                                   333


<210>  24
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m3

<400>  24
cagagcgccc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcaccagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagctgat gatctatgtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgagca acagattctc cggcagcaag tccggcaaca ccgccagctt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg ctg                                   333


<210>  25
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m4

<400>  25
cagagcgctc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcacaagcgc ccacaagacc tacaccgtga gctggtacca gcagcacccc      120

ggcaaggccc ccaagtattt aatgcaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctg                                   333


<210>  26
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m5

<400>  26
cagtctgctc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcacaagcgc ccacaagacc tacaccgtga gttggtacca gcagcacccc      120

ggcaaggccc ccaagttgat gatctacgtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tattgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctc                                   333


<210>  27
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  Rabbit P4-10 light chain variable region

<400>  27

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  28
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1

<400>  28

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  29
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m1

<400>  29

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  30
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m2

<400>  30

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  31
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m3

<400>  31

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  32
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m4

<400>  32

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  33
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2

<400>  33

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Gln Arg Pro Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  34
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m1

<400>  34

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  35
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m2

<400>  35

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  36
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m3

<400>  36

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  37
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3

<400>  37

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105                 110     


<210>  38
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m1

<400>  38

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr 
            100                 105                 110     


<210>  39
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m2

<400>  39

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  40
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m3

<400>  40

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  41
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m4

<400>  41

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  42
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m5

<400>  42

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
            100                 105                 110     


<210>  43
<211>  759
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  0.410HC.410LC

<400>  43
cagttcgtgc tgacccagag ccctagcgtg agcgctgctc tgggagccag cgccaagctc       60

acttgtactt taagctccgc ccacaaaacc tacaccatcg actggtacca gcagcagcaa      120

ggtgaggccc ccagatattt aatgcaagtt aagtccgatg gcagctacac caagggcacc      180

ggagtgcccg ataggttcag cggcagctcc agcggcgccg ataggtattt aatcatcccc      240

agcgtgcaag ctgatgatga ggccggctac gtgtgtggcg ccgacgacaa cggcggctac      300

gtgttcggag gcggaaccca gctgacagtg accggaggcg gaagctccag aagctccagc      360

agcggaggag gaggaagcgg aggaggcgga cagtccgtca aggagagcga gggcggttta      420

tttaagccca ccgacacttt aactttaact tgtacagtga gcggcttctc tttatccaga      480

cacgctttaa catgggtgag gcaagctccc ggtaatggtt tagagtggat cggcgccatc      540

gacaacgccg gcaccaccta ctacgccagc tgggccaagt ctcgttccac catcacaaga      600

aacaccgatt tacacaccgt gactttaaag atgacctctt taaccgcctc cgacaccgcc      660

acatacttct gcgctcgtgt gttctacgac atcaattccg gctactattt agacggcatg      720

gatttatggg gccccggtac tttagtgacc gtctccagc                             759


<210>  44
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  1.H1.L3

<400>  44
cagtccgctt taacacagcc cgcttctgtg tccggaagcc ccggtcagag catcaccatc       60

agctgcaccg gcaccagcgc tcacaagacc tacaccgtga gctggtacca gcagcacccc      120

ggtaaggccc ccaaactgat gatctacgtg aagagcgacg gcagctacaa cagacccagc      180

ggcgtgagca atcgtttcag cggcagcaag agcggcaaca ccgcttcttt aaccatcagc      240

ggtttacaag ctgaagacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgtttggcg gcggcaccaa actgaccgtg ctgggaggcg gctccagcag aagctcctcc      360

agcggaggag gaggaagcgg aggcggagga caagttcagc tgcaagaaag cggacccggt      420

ttagtcaagc ccagcgagac tttatcttta acatgcgccg tgagcggcta ctccatctct      480

cgtcacgctt taacatggat taggcagccc cccggtaagg gtttagaatg gatcggcgcc      540

atcgacaacg ctggcaccac ctactacgcc tcttgggcta agtctcgtgt gacaatcagc      600

gtggacacct ccaagaacca gttttcttta aagctgagca gcgtgaccgc tgccgacacc      660

gctgtgtact attgcgctcg tgtcttctac gacatcaaca gcggctacta tttagatggc      720

atggatttat ggggacccgg tactttagtg accgtgagct cc                         762


<210>  45
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  2.H1.L3m1

<400>  45
cagttcgtgc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagtattt aatgcaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat gtgtgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg actggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  46
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  3.H1m1.L3

<400>  46
cagtccgctt taacccagcc cgcctctgtg tccggaagcc ccggccagag catcaccatc       60

agctgcaccg gcacctccgc ccacaagacc tacaccgtga gctggtatca gcagcacccc      120

ggcaaggccc ccaagctcat gatctacgtg aagagcgacg gctcctacaa tcgtcccagc      180

ggagtgagca atcgtttcag cggctccaag tccggcaaca ccgcctcttt aaccattagc      240

ggtttacaag ctgaggacga ggctgattac tactgcggcg ccgacgataa cggaggctac      300

gtgttcggcg gcggaacaaa gctgaccgtg ctgggcggag gctccagcag aagcagctcc      360

agcggaggcg gaggaagcgg aggaggagga cagcagagcg tgaaggagag cggccccggt      420

ctggtgaagc ccagcgagac tttatcttta acatgcgccg tgagcggctt ctctttatct      480

cgtcacgctt taacttgggt gagacagcct cccggtaaag gtttagagtg gatcggcgcc      540

atcgacaacg ccggcacaac ctactacgcc agctgggcca agtctcgtgt gaccatctct      600

cgtaacaccg atttacacac cgtgtcttta aagctgagct ccgtgaccgc tgccgatacc      660

gccgtgtact tctgcgctag ggtgttctac gacatcaaca gcggctacta tttagatggc      720

atggatctgt ggggccccgg cacactggtc acagtgtcca gc                         762


<210>  47
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  4.H1m1.L3m1

<400>  47
cagttcgtgc tgacccagcc cgcttccgtg agcggttctc ccggacagag catcaccatt       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcatccc      120

ggcaaggccc ccaagtacct catgcaagtt aagagcgacg gaagctatac caagggcacc      180

ggagtgccca acagattcag cggcagcagc tccggagccg atcgttattt aacaatcagc      240

ggactgcaag ctgaggacga ggccgactac gtgtgtggcg ccgacgacaa tggcggctac      300

gtgtttggag gcggaaccca gctgaccgtg actggaggcg gcagcagcag aagcagcagc      360

agcggaggag gtggcagcgg cggaggcgga cagcagagcg tgaaggagag cggacccggt      420

ttagtgaagc ctagcgagac tttatcttta acatgcgccg tgtccggctt ctctttaagc      480

agacacgctc tgacttgggt gaggcagcct cccggtaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca agtccagagt gaccatctcc      600

agaaacaccg acctccacac agtgtcttta aagctgtcct ccgtcacagc tgccgacacc      660

gccgtgtact tctgcgctcg tgtgttctac gacatcaaca gcggctatta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtgagca gc                         762


<210>  48
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  5.H2.L2

<400>  48
cagagcgtgc tgacacagcc tcctagcgcc agcggcacac ccggtcagag agtgaccatc       60

agctgctccg gcagcagcgc ccacaagacc tacaccgtga actggtacca gcagctgccc      120

ggcacagccc ctaagctgct gatctacgtg aaatccgacg gcagctacca gaggcctagc      180

ggagtgcccg atcgtttcag cggcagcaaa agcggcacaa gcgcctcttt agctatcagc      240

ggtttacaga gcgaggacga ggccgactat tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggaaccaa gctgacagtg ctgggcggcg gaagcagcag aagcagcagc      360

tctggaggag gaggaagcgg aggtggaggc gaggtgcagc tggtggaaag cggcggagga      420

ctggtgcagc ccggtggctc tttaagactg agctgtgctg ccagcggctt cacattctct      480

cgtcacgctt taacttgggt gagacaagct cccggaaagg gtttagaatg ggtgagcgcc      540

atcgacaacg ccggaaccac ctactacgcc agctgggcca agtctcgttt caccatctct      600

cgtgataacg ccaagaacag cctctattta cagatgaact ctttaagggc cgaggacacc      660

gccgtgtact actgcgctag ggtgttctac gacatcaaca gcggctacta tctggacggc      720

atggatttat ggggccccgg tacactggtc accgtgagca gc                         762


<210>  49
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  6.H2.L2m1

<400>  49
cagttcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagctcc agcggcgccg ataggtattt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg accggaggag gctcctctcg tagctccagc      360

tccggaggag gaggaagcgg aggcggcgga gaagtgcaac tggtggagtc cggcggcgga      420

ctggtgcagc ccggtggctc tttaagactg agctgtgccg cctccggctt cacctttagc      480

agacacgccc tcacttgggt cagacaagct cccggtaagg gtttagagtg ggtgagcgcc      540

atcgacaacg ccggcacaac ctactacgcc tcttgggcca agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaact ctttaagggc cgaggacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctatta tttagatggc      720

atggatttat ggggccccgg tactttagtg acagtgtcct cc                         762


<210>  50
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  7.H2m1.L2

<400>  50
cagagcgtgc tgacccagcc tcctagcgcc tctggcacac ccggtcagag ggtgaccatc       60

agctgctccg gctcctccgc ccacaagacc tacaccgtga actggtacca gcagctgccc      120

ggtaccgctc ccaagctgct gatttacgtg aaaagcgacg gcagctacca gagacctagc      180

ggcgtgcccg atcgtttctc cggttctaag agcggcacca gcgcctcttt agccattagc      240

ggcctccaga gcgaggacga ggccgattac tactgcggag ccgacgacaa tggcggctac      300

gtgttcggcg gcggaacaaa gctgaccgtt ttaggtggcg gaagcagcag aagcagcagc      360

tctggcggcg gcggtagcgg cggtggcgga gagcagagcg tcaaggagtc cggaggagga      420

ctggtgcagc ccggtggctc tttaaggctg agctgtgccg cctctggctt tactttatct      480

cgtcacgctt taacatgggt gagacaagct cccggtaagg gactggagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc tcttgggcca agtctcgttt caccatctct      600

cgtaacaccg atttacacac cgtgtattta cagatgaact ctttaagggc cgaggacaca      660

gccgtctatt tctgcgctcg tgtgttctac gacatcaata gcggctacta cctcgacgga      720

atggatctgt ggggccccgg tactttagtg acagtcagca gc                         762


<210>  51
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  8.H2m1.L2m1

<400>  51
cagtttgttt taacccagcc tcctagcgcc tctggaacac ccggccaaag ggtcaccatc       60

agctgcactt tatcctccgc ccacaagacc tacaccatcg actggtacca gcagctgccc      120

ggaaccgccc ctaagctgct gatctacgtg aagagcgacg gcagctacac caagggcacc      180

ggcgtgcccg ataggttcag cggcagcagc agcggcgccg atagatattt agccatttcc      240

ggtttacaga gcgaggacga ggccgattac tactgtggcg ctgacgacaa cggaggctac      300

gtgttcggag gcggcaccca gctgaccgtg actggtggcg gttctagcag aagcagcagc      360

tccggaggcg gaggctctgg cggcggtggc gagcagtccg tgaaggaaag cggcggcgga      420

ctggtgcagc ccggtggatc tttaagactg agctgcgccg cctctggctt cactttatcc      480

agacatgctt taacatgggt gagacaagct cccggcaagg gactggagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgttt caccatctct      600

cgtaacaccg atttacacac cgtgtattta cagatgaatt ctttaagggc cgaggacacc      660

gccgtgtact tctgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggacccgg tacactcgtg accgtgtcca gc                         762


<210>  52
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  9.H2.L1

<400>  52
cagctggtgc tgacccagag ccccagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt taagcagcgc ccacaagacc tacacaatcg cttggcacca gcagcagccc      120

gaaaagggcc ccagatatct gatgaaggtc aagtccgacg gcagctactc caagggcgac      180

ggcatccccg atcgtttcag cggttcttcc agcggcgccg agaggtattt aaccatcagc      240

tctttacaga gcgaggacga ggccgactac tactgcggcg ctgacgacaa cggcggctac      300

gtctttggcg gcggcacaaa actgaccgtg ctgggcggcg gaagcagcag aagctccagc      360

tctggaggag gaggttctgg aggtggagga gaggtgcagc tggtggagag cggcggagga      420

ctggtgcagc ccggtggatc tttaagactg agctgtgccg ccagcggctt caccttctct      480

cgtcacgctc tgacatgggt gaggcaagcc cccggtaagg gtttagaatg ggtgagcgcc      540

atcgacaatg ccggaaccac ctattacgcc tcttgggcca agtctcgttt caccatctct      600

cgtgacaatg ccaagaactc tttatattta cagatgaact ctttaagagc tgaggacacc      660

gccgtctact actgcgccag agtgttctac gacatcaaca gcggctacta cctcgacggc      720

atggatttat ggggccccgg tactttagtg accgtgagca gc                         762


<210>  53
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  10.H2.L1m1

<400>  53
cagtttgtgc tgacccagag ccctagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt tatcctccgc ccacaagacc tacaccatcg actggtacca gcagcagccc      120

gaaaagggcc ctcgttatct gatgcaagtt aagtccgacg gcagctacac caagggaacc      180

ggcgtgcccg acagattctc cggtagcagc agcggcgccg acagatattt aaccatcagc      240

tctttacagt ccgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggag gcggcacaca gctgaccgtg actggtggag gctcctccag aagcagctct      360

agcggaggag gaggaagcgg cggaggaggc gaagtgcagc tggtggagtc cggaggagga      420

ctggtgcagc ccggaggttc tttaagactg agctgcgccg cctccggctt caccttttct      480

cgtcacgctt taacatgggt gagacaagct cccggcaagg gactggaatg ggtcagcgcc      540

atcgataacg ccggcaccac ctattacgcc agctgggcta agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaatt ctttaagagc cgaggacacc      660

gccgtgtatt actgcgctcg tgtcttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtc accgtgagct cc                         762


<210>  54
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  11.H2m1.L1

<400>  54
cagctggtgc tgacacagag cccctccgcc tccgcctctt taggcgcttc cgtgaagctg       60

acttgtactt tatccagcgc ccacaagacc tacaccatcg cttggcacca gcagcagccc      120

gagaaaggcc ctcgttacct catgaaagtg aagtccgacg gcagctactc caagggcgac      180

ggcatccccg atcgttttag cggcagcagc tccggcgccg agaggtattt aaccatcagc      240

tctttacaga gcgaagacga ggccgactat tactgcggcg ccgatgacaa cggaggctac      300

gtgttcggcg gaggcaccaa actgaccgtg ctgggcggcg gaagcagcag aagctccagc      360

agcggaggag gaggttctgg aggaggcgga gagcagagcg tgaaagagtc cggcggaggt      420

ttagtgcagc ccggtggttc tttaagactg agctgcgccg ccagcggctt cacactgtcc      480

agacacgctt taacatgggt gagacaagct cccggtaagg gactggagtg gatcggcgcc      540

atcgacaatg ccggcaccac ctactacgcc agctgggcca agtctcgttt caccatctct      600

cgtaacaccg atttacacac cgtctattta cagatgaact ctttaagggc cgaggacaca      660

gccgtgtact tttgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatctgt ggggccccgg aacactggtg accgtgagca gc                         762


<210>  55
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  12.H2m1.L1m1

<400>  55
cagtttgtgc tgacccagtc ccctagcgcc tctgcctctt taggagcctc tgtgaaactg       60

acttgtactt taagcagcgc ccacaagaca tacaccatcg actggtacca gcagcagccc      120

gaaaagggcc ctaggtattt aatgcaagtt aagagcgacg gcagctacac aaagggcact      180

ggtgtgcccg acagattcag cggcagcagc agcggcgccg acagatacct caccatcagc      240

tctttacagt ccgaggacga ggccgactac tattgcggcg ccgacgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctgaccgtg actggtggcg gaagcagcag aagcagctcc      360

tccggaggcg gaggttctgg cggaggtgga gaacagagcg tgaaggagag cggaggtgga      420

ctggtgcagc ccggtggttc tttaagactg agctgcgctg cctccggctt caccttatct      480

cgtcacgctt taacatgggt gagacaagct cccggtaagg gtttagagtg gatcggcgcc      540

atcgacaatg ctggcaccac ctactacgcc agctgggcca agtctcgttt cacaatctct      600

cgtaacaccg atctgcacac cgtgtattta cagatgaact ctttaagagc cgaggacacc      660

gccgtgtatt tctgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtgagct cc                         762


<210>  56
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  13.H1.L1

<400>  56
cagctcgtgc tgacccagtc ccccagcgcc tctgcctctt taggcgccag cgtgaagctg       60

acttgtactt tatccagcgc ccacaagaca tacaccatcg cttggcacca gcagcagccc      120

gaaaagggcc ctcgttattt aatgaaggtc aagtccgacg gctcctactc caagggcgac      180

ggcatccccg atagattcag cggtagcagc agcggcgccg agagatattt aacaatcagc      240

tctttacaga gcgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggcg gcggaaccaa gctcacagtg ctgggtggag gctccagcag aagcagctct      360

agcggaggcg gaggttccgg cggcggaggc caagttcagc tgcaagaatc cggccccgga      420

ctggtgaagc cctccgaaac actgtcttta acatgcgccg tgagcggcta cagcatttct      480

cgtcacgctt taacttggat cagacagccc cccggcaagg gtttagaatg gatcggagcc      540

atcgataacg ccggcaccac atactacgcc agctgggcca agagcagagt gaccatctcc      600

gtggacacca gcaagaacca gttttcttta aagctcagct ccgtgaccgc cgccgataca      660

gccgtgtact actgcgccag agtgttctac gacatcaaca gcggctacta tttagacgga      720

atggatttat ggggccccgg tactttagtg accgtgagca gc                         762


<210>  57
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  14.H1.L1m1

<400>  57
cagtttgtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg actggtacca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcgtgcccg acagattcag cggcagctcc agcggagccg atcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg accggaggcg gttcttctcg tagcagcagc      360

agcggaggcg gcggctccgg cggcggaggc caagttcagc tgcaagaatc cggccccggt      420

ctggtgaaac ccagcgagac tttatcttta acatgcgccg tgagcggcta ctccatctcc      480

agacacgctt taacttggat cagacagcct cccggcaagg gactggagtg gatcggcgct      540

atcgacaacg ccggcaccac ctactacgcc tcttgggcca agtctcgtgt caccatcagc      600

gtggacacat ccaagaacca gttctcttta aagctgtcca gcgtgaccgc cgccgataca      660

gccgtgtact actgcgctcg tgtgttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggacccgg tactttagtg accgtgtcca gc                         762


<210>  58
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  15.H1m1.L1

<400>  58
cagctggtgc tgacacaaag ccccagcgcc agcgcctctt taggcgccag cgtcaaactg       60

acatgcactt taagcagcgc ccacaagacc tacaccatcg cttggcacca gcagcagccc      120

gagaagggcc ccagatattt aatgaaggtg aagtccgatg gcagctacag caagggagat      180

ggcattcccg atcgttttag cggctcctcc agcggcgccg agagatactt aaccatctcc      240

tctttacaga gcgaggacga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gcggaaccaa gctgaccgtg ctgggcggag gcagctccag atccagcagc      360

agcggcggag gaggaagcgg aggaggagga cagcagtccg tgaaagagag cggccccggt      420

ttagtgaaac ccagcgagac tttatcttta acttgtgccg tgagcggctt cagcctctct      480

cgtcacgctt taacttgggt gagacagcct cccggcaaag gtttagagtg gattggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccatttcc      600

agaaacaccg atttacacac cgtgtcttta aagctgtcca gcgtgaccgc cgctgacacc      660

gctgtctact tctgcgctcg tgtgttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtgagct cc                         762


<210>  59
<211>  763
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  16.H1m1.L1m1

<400>  59
cagttcgtgc tcacacagag ccctagcgct tccgcctctt taggagccag cgtgaaactg       60

acatgtactt taagcagcgc ccacaaaacc tacaccatcg actggtacca gcagcaaccc      120

gagaagggcc ctagatattt aatgcaagtt aagagcgacg gctcctacac caaaggcacc      180

ggcgtgcccg ataggttcag cggctcctcc tccggagccg atcgttattt aacaatcagc      240

tctttacaga gcgaagacga ggccgattac tactgcggag ccgatgacaa cggcggctac      300

gtcttcggag gcggaaccca gctgacagtg accggaggcg gcagcagcag atccagcagc      360

tccggaggcg gaggaagcgg aggaggcggc cagcaaagcg tgaaggagag cggccccgga      420

ctcgtgaaac cctccgagac tttatcttta acttgtgccg tgagcggctt ctctttatct      480

cgtcacgctt taacatgggt gaggcagcct cccggtaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcacaac ctactacgcc agctgggcca agagcagagt gaccatctct      600

cgtaacaccg atttacacac cgtgtcttta aagctgagct ccgtgaccgc cgccgatacc      660

gctgtgtact tctgcgctcg tgtcttctac gacatcaact ccggctatta cctcgacggc      720

atggatctgt ggggccccgg aacactggtg accgtgagca gcg                        763


<210>  60
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  17.H1.L3m2

<400>  60
cagttcgtgc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagctgat gatccaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgagca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg ctgggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  61
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  18.H1.L3m3

<400>  61
cagagcgccc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcaccagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagctgat gatctatgtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgagca acagattctc cggcagcaag tccggcaaca ccgccagctt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg ctgggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  62
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  19.H2.L2m2

<400>  62
cagttcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagctcc agcggcgccg atgccagctt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg ctgggaggag gctcctctcg tagctccagc      360

tccggaggag gaggaagcgg aggcggcgga gaagtgcaac tggtggagtc cggcggcgga      420

ctggtgcagc ccggtggctc tttaagactg agctgtgccg cctccggctt cacctttagc      480

agacacgccc tcacttgggt cagacaagct cccggtaagg gtttagagtg ggtgagcgcc      540

atcgacaacg ccggcacaac ctactacgcc tcttgggcca agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaact ctttaagggc cgaggacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctatta tttagatggc      720

atggatttat ggggccccgg tactttagtg acagtgtcct cc                         762


<210>  63
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  20.H2.L2m3

<400>  63
cagagcgtgc tgacacagcc tcccagcgcc tctggcacac ccggtcagag ggtgaccatc       60

tcttgtactt tatcctccgc ccacaagacc tacaccattg actggtacca gcagctgccc      120

ggtaccgccc ctaagctgct gatttacgtg aaatccgacg gcagctacac caagggaacc      180

ggcgtgcccg atcgtttttc cggcagcaag agcggcacca gcgccagctt agccatcagc      240

ggtttacagt ccgaggatga ggccgactac tactgcggcg ccgatgacaa cggcggctac      300

gtgttcggcg gaggaaccca gctcaccgtg ctgggaggag gctcctctcg tagctccagc      360

tccggaggag gaggaagcgg aggcggcgga gaagtgcaac tggtggagtc cggcggcgga      420

ctggtgcagc ccggtggctc tttaagactg agctgtgccg cctccggctt cacctttagc      480

agacacgccc tcacttgggt cagacaagct cccggtaagg gtttagagtg ggtgagcgcc      540

atcgacaacg ccggcacaac ctactacgcc tcttgggcca agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaact ctttaagggc cgaggacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctatta tttagatggc      720

atggatttat ggggccccgg tactttagtg acagtgtcct cc                         762


<210>  64
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  21.H2.L1m2

<400>  64
cagtttgtgc tgacccagag ccctagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt tatcctccgc ccacaagacc tacaccatcg actggcacca gcagcagccc      120

gaaaagggcc ctcgttatct gatgcaagtt aagtccgacg gcagctacac caagggaacc      180

ggcatccccg acagattctc cggtagcagc agcggcgccg agagatattt aaccatcagc      240

tctttacagt ccgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggag gcggcacaca gctgaccgtg ctgggtggag gctcctccag aagcagctct      360

agcggaggag gaggaagcgg cggaggaggc gaagtgcagc tggtggagtc cggaggagga      420

ctggtgcagc ccggaggttc tttaagactg agctgcgccg cctccggctt caccttttct      480

cgtcacgctt taacatgggt gagacaagct cccggcaagg gactggaatg ggtcagcgcc      540

atcgataacg ccggcaccac ctattacgcc agctgggcta agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaatt ctttaagagc cgaggacacc      660

gccgtgtatt actgcgctcg tgtcttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtc accgtgagct cc                         762


<210>  65
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  22.H1.L1m2

<400>  65
cagtttgtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg actggcacca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcatccccg acagattcag cggcagctcc agcggagccg agcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctgggaggcg gttcttctcg tagcagcagc      360

agcggaggcg gcggctccgg cggcggaggc caagttcagc tgcaagaatc cggccccggt      420

ctggtgaaac ccagcgagac tttatcttta acatgcgccg tgagcggcta ctccatctcc      480

agacacgctt taacttggat cagacagcct cccggcaagg gactggagtg gatcggcgct      540

atcgacaacg ccggcaccac ctactacgcc tcttgggcca agtctcgtgt caccatcagc      600

gtggacacat ccaagaacca gttctcttta aagctgtcca gcgtgaccgc cgccgataca      660

gccgtgtact actgcgctcg tgtgttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggacccgg tactttagtg accgtgtcca gc                         762


<210>  66
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  23.H1.L2m1

<400>  66
cagttcgtgc tgacccagcc tcctagcgct agcggaacac ccggccagag ggtgaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagctgccc      120

ggtaccgctc ccaagctgct gatctacgtg aagagcgacg gcagctacac caagggcacc      180

ggcgtgcccg atagattcag cggcagcagc agcggcgccg acagatattt agccatcagc      240

ggtttacaga gcgaggacga ggccgactac tactgcggcg ccgacgacaa cggaggctac      300

gtgttcggcg gcggcacaca gctgaccgtg accggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  67
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  24.H2.L3m1

<400>  67
cagttcgtgc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactt taagcagcgc ccacaagacc tacaccatcg actggtacca gcagcacccc      120

ggcaaggccc ccaagtattt aatgcaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat gtgtgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcacaca gctgaccgtg actggcggtg gttcctctag atcttcctcc      360

tctggtggcg gtggctcggg cggtggtggg gaggtgcagc tggtggagag cggaggaggt      420

ttagtgcagc ccggtggatc tttaagactg agctgcgccg ccagcggctt caccttctct      480

cgtcacgctt taacatgggt gagacaagct cccggtaaag gtttagagtg ggtgagcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca agtctcgttt caccatctct      600

cgtgacaacg ccaagaactc tttatattta cagatgaact ctttaagggc tgaggacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacgga      720

atggatttat ggggccccgg taccctcgtg acagtgagca gc                         762


<210>  68
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  25.H1.L1m3

<400>  68
cagctggtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg actggtacca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcgtgcccg acagattcag cggcagctcc agcggagccg atcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctgggaggcg gttcttctcg tagcagcagc      360

agcggaggcg gcggctccgg cggcggaggc caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  69
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  26.H1.L1m4

<400>  69
cagttggtgc tcacccaaag ccctagcgcc tctgcctctt taggcgcttc cgtgaagctg       60

acttgtactt taagctccgc ccataagacc tacaccatcg cctggcatca gcagcagccc      120

gagaagggcc ctcgttattt aatgcaagtt aagtccgatg gcagctatac caagggcacc      180

ggcgtgcccg acagattcag cggcagctcc agcggagccg atcgttattt aaccatcagc      240

tctttacaga gcgaggacga ggctgactac tactgcggcg ccgacgataa cggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctcggaggcg gttcttctcg tagcagcagc      360

agcggaggcg gcggctccgg cggcggaggc caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  70
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  27.H1.L3m4

<400>  70
cagagcgctc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcacaagcgc ccacaagacc tacaccgtga gctggtacca gcagcacccc      120

ggcaaggccc ccaagtattt aatgcaagtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tactgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctgggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  71
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  28.H1.L3m5

<400>  71
cagtctgctc tgacccagcc cgcttctgtg agcggttctc ccggtcagag catcaccatc       60

agctgcactg gcacaagcgc ccacaagacc tacaccgtga gttggtacca gcagcacccc      120

ggcaaggccc ccaagttgat gatctacgtt aagtccgacg gcagctacac caagggcacc      180

ggcgtgccca acagattctc cggcagcagc tccggcgccg acagatactt aaccatcagc      240

ggtttacaag ctgaggatga ggccgactat tattgcggcg ccgacgacaa tggcggctac      300

gtgttcggcg gcggcaccca actgacagtg ctcggtggag gctccagcag atccagctcc      360

agcggcggag gaggcagcgg aggcggagga caagtgcagc tccaagaatc cggccccggt      420

ctcgtgaagc ccagcgagac tttatcttta acttgtgccg tgagcggcta cagcatctct      480

cgtcacgctc tgacttggat tcgtcaacct cccggaaagg gtttagagtg gatcggcgcc      540

atcgacaacg ccggcaccac ctactacgcc agctgggcca aatctcgtgt gaccattagc      600

gtggacacca gcaagaacca gttctcttta aaactgagca gcgtgacagc tgccgacacc      660

gccgtgtact actgcgctcg tgtgttctac gacatcaaca gcggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtg accgtcagct cc                         762


<210>  72
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  29.H2.L1m3

<400>  72
cagctggtgc tgacccagag ccctagcgct tccgcctctt taggagccag cgtgaagctg       60

acttgtactt tatcctccgc ccacaagacc tacaccatcg actggtacca gcagcagccc      120

gaaaagggcc ctcgttatct gatgcaagtt aagtccgacg gcagctacac caagggaacc      180

ggcgtgcccg acagattctc cggtagcagc agcggcgccg acagatattt aaccatcagc      240

tctttacagt ccgaggacga ggccgactac tactgcggcg ccgacgacaa tggcggctac      300

gtcttcggag gcggcacaca gctgaccgtg actggtggag gctcctccag aagcagctct      360

agcggaggag gaggaagcgg cggaggaggc gaagtgcagc tggtggagtc cggaggagga      420

ctggtgcagc ccggaggttc tttaagactg agctgcgccg cctccggctt caccttttct      480

cgtcacgctt taacatgggt gagacaagct cccggcaagg gactggaatg ggtcagcgcc      540

atcgataacg ccggcaccac ctattacgcc agctgggcta agtctcgttt caccatcagc      600

agagacaacg ccaagaactc tttatattta cagatgaatt ctttaagagc cgaggacacc      660

gccgtgtatt actgcgctcg tgtcttctac gacatcaact ccggctacta tttagacggc      720

atggatttat ggggccccgg tactttagtc accgtgagct cc                         762


<210>  73
<211>  253
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  0.410HC.410LC

<400>  73

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr 
    130                 135                 140                 


Asp Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg 
145                 150                 155                 160 


His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp 
                165                 170                 175     


Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala 
            180                 185                 190         


Lys Ser Arg Ser Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr 
        195                 200                 205             


Leu Lys Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys 
    210                 215                 220                 


Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met 
225                 230                 235                 240 


Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250             


<210>  74
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  1.H1.L3

<400>  74

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  75
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  2.H1.L3m1

<400>  75

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Ala Ser 
                245                 250                 255     


Thr Lys Gly Pro Ser Val Thr Ser 
            260                 


<210>  76
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  3.H1m1.L3

<400>  76

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  77
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  4.H1m1.L3m1

<400>  77

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  78
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  5.H2.L2

<400>  78

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Gln Arg Pro Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  79
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  6.H2.L2m1

<400>  79

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  80
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  7.H2m1.L2

<400>  80

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Gln Arg Pro Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  81
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  8.H2m1.L2m1

<400>  81

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  82
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  9.H2.L1

<400>  82

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  83
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  10.H2.L1m1

<400>  83

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  84
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  11.H2m1.L1

<400>  84

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  85
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  12.H2m1.L1m1

<400>  85

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  86
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  13.H1.L1

<400>  86

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  87
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  14.H1.L1m1

<400>  87

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  88
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  15.H1m1.L1

<400>  88

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  89
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  16.H1m1.L1m1

<400>  89

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  90
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  17.H1.L3m2

<400>  90

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  91
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  18.H1.L3m3

<400>  91

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  92
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  19.H2.L2m2

<400>  92

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  93
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  20.H2.L2m3

<400>  93

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  94
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  21.H2.L1m2

<400>  94

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  95
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  22.H1.L1m2

<400>  95

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  96
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  23.H1.L2m1

<400>  96

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  97
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  24.H2.L3m1

<400>  97

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  98
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  25.H1.L1m3

<400>  98

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  99
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  26.H1.L1m4

<400>  99

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  100
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  27.H1.L3m4

<400>  100

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  101
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  28.H1.L3m5

<400>  101

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
    130                 135                 140                 


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
        195                 200                 205             


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  102
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  29.H2.L1m3

<400>  102

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Thr Gly 
            100                 105                 110         


Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    130                 135                 140                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
145                 150                 155                 160 


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
                165                 170                 175     


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
            180                 185                 190         


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
        195                 200                 205             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
225                 230                 235                 240 


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser 
                245                 250                 


<210>  103
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR10

<400>  103
gaggtgcagc tggtggagtc tggaggagga ctggtgcaac ccggtggctc tttaagactg       60

agctgcgccg cctctggctt caccttttct cgtcacgctt taacatgggt gagacaagct      120

cccggaaagg gactggagtg ggtgtccgcc atcgacaacg ccggcaccac ctactacgcc      180

agctgggcca agagcagatt caccatctct cgtgacaacg ccaagaactc tttatattta      240

cagatgaact ctttaagggc cgaggacacc gccgtgtact actgcgctcg tgtgttctac      300

gacatcaact ccggctacta tttagacggc atggatttat ggggacccgg tacactggtc      360

acagtgagct ctggaggcgg aggtagcgga ggcggaggaa gcagcggtgg aggcagccag      420

tttgtgctga cacagtcccc ttccgcttcc gcctctttag gagcctccgt gaagctgact      480

tgtactttaa gcagcgccca caaaacctac accatcgact ggtaccagca gcagcccgag      540

aagggcccac gttatttaat gcaagttaag tccgacggct cctacaccaa gggcaccggc      600

gtgcccgata gattcagcgg ctccagcagc ggcgccgata ggtatttaac catctcctct      660

ttacagagcg aggacgaggc cgactactac tgtggcgccg acgacaacgg cggctacgtg      720

tttggaggcg gcacccagct gaccgtgctg                                       750


<210>  104
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR14

<400>  104
caagttcagc tgcaagaaag cggacccggt ttagtgaaac cctccgagac tttatcttta       60

acatgcgccg tgagcggcta cagcatctct cgtcatgctt taacttggat tcgtcagcct      120

cccggaaagg gtttagagtg gatcggcgcc atcgacaacg ccggcaccac ctattacgcc      180

agctgggcca agtctcgtgt gaccatcagc gtggacacca gcaagaacca gttctcttta      240

aagctgtcca gcgtgaccgc tgccgacaca gccgtgtact actgcgctcg tgtgttctac      300

gacatcaaca gcggctacta tttagacgga atggatctgt ggggccccgg aactttagtg      360

acagtcagca gcggaggcgg aggaagcgga ggaggaggaa gctccggagg cggttctcaa      420

ttcgtgctga cacagagccc tagcgcctct gcctctttag gagcctccgt gaagctgact      480

tgtactttaa gcagcgccca caagacctac accatcgact ggtaccagca gcagcccgag      540

aagggcccta gatatttaat gcaagttaag agcgacggca gctacaccaa aggcactggt      600

gtgcccgatc gttttagcgg cagcagcagc ggcgccgata ggtatttaac catcagctct      660

ttacagagcg aggacgaggc cgactactac tgtggcgccg acgacaacgg cggctacgtg      720

tttggcggcg gcacacagct gaccgtttta                                       750


<210>  105
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR25

<400>  105
caagttcagc tgcaagaaag cggacccggt ttagtgaaac cctccgagac tttatcttta       60

acatgcgccg tgagcggcta cagcatctct cgtcatgctt taacttggat tcgtcagcct      120

cccggaaagg gtttagagtg gatcggcgcc atcgacaacg ccggcaccac ctattacgcc      180

agctgggcca agtctcgtgt gaccatcagc gtggacacca gcaagaacca gttctcttta      240

aagctgtcca gcgtgaccgc tgccgacaca gccgtgtact actgcgctcg tgtgttctac      300

gacatcaaca gcggctacta tttagacgga atggatctgt ggggccccgg aactttagtg      360

acagtcagca gcggaggcgg aggaagcgga ggaggaggaa gctccggagg cggttctcaa      420

ctggtgctga cacagagccc tagcgcctct gcctctttag gagcctccgt gaagctgact      480

tgtactttaa gcagcgccca caagacctac accatcgact ggtaccagca gcagcccgag      540

aagggcccta gatatttaat gcaagttaag agcgacggca gctacaccaa aggcactggt      600

gtgcccgatc gttttagcgg cagcagcagc ggcgccgata ggtatttaac catcagctct      660

ttacagagcg aggacgaggc cgactactac tgtggcgccg acgacaacgg cggctacgtg      720

tttggcggcg gcacacagct gaccgtttta                                       750


<210>  106
<211>  750
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR29

<400>  106
gaggtgcagc tggtggagtc tggaggagga ctggtgcaac ccggtggctc tttaagactg       60

agctgcgccg cctctggctt caccttttct cgtcacgctt taacatgggt gagacaagct      120

cccggaaagg gactggagtg ggtgtccgcc atcgacaacg ccggcaccac ctactacgcc      180

agctgggcca agagcagatt caccatctct cgtgacaacg ccaagaactc tttatattta      240

cagatgaact ctttaagggc cgaggacacc gccgtgtact actgcgctcg tgtgttctac      300

gacatcaact ccggctacta tttagacggc atggatttat ggggacccgg tacactggtc      360

acagtgagct ctggaggcgg aggtagcgga ggcggaggaa gcagcggtgg aggcagccag      420

ctggtgctga cacagtcccc ttccgcttcc gcctctttag gagcctccgt gaagctgact      480

tgtactttaa gcagcgccca caaaacctac accatcgact ggtaccagca gcagcccgag      540

aagggcccac gttatttaat gcaagttaag tccgacggct cctacaccaa gggcaccggc      600

gtgcccgata gattcagcgg ctccagcagc ggcgccgata ggtatttaac catctcctct      660

ttacagagcg aggacgaggc cgactactac tgtggcgccg acgacaacgg cggctacgtg      720

tttggaggcg gcacccagct gaccgtgctg                                       750


<210>  107
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR10

<400>  107

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Phe Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys Ser Asp 
            180                 185                 190         


Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly Tyr Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250 


<210>  108
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR14

<400>  108

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Phe Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys Ser Asp 
            180                 185                 190         


Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly Tyr Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250 


<210>  109
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR25

<400>  109

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys Ser Asp 
            180                 185                 190         


Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly Tyr Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250 


<210>  110
<211>  250
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  scFv

<220>
<223>  CAR29

<400>  110

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp 
            100                 105                 110         


Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Leu Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys Leu Thr 
145                 150                 155                 160 


Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp Tyr Gln 
                165                 170                 175     


Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys Ser Asp 
            180                 185                 190         


Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser Gly Ser 
        195                 200                 205             


Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
    210                 215                 220                 


Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly Tyr Val 
225                 230                 235                 240 


Phe Gly Gly Gly Thr Gln Leu Thr Val Leu 
                245                 250 


<210>  111
<211>  9088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  pTRPE-C10-gs-BBz

<400>  111
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatccgagg tgcagctggt ggagtctgga ggaggactgg tgcaacccgg tggctcttta     5640

agactgagct gcgccgcctc tggcttcacc ttttctcgtc acgctttaac atgggtgaga     5700

caagctcccg gaaagggact ggagtgggtg tccgccatcg acaacgccgg caccacctac     5760

tacgccagct gggccaagag cagattcacc atctctcgtg acaacgccaa gaactcttta     5820

tatttacaga tgaactcttt aagggccgag gacaccgccg tgtactactg cgctcgtgtg     5880

ttctacgaca tcaactccgg ctactattta gacggcatgg atttatgggg acccggtaca     5940

ctggtcacag tgagctctgg aggcggaggt agcggaggcg gaggaagcag cggtggaggc     6000

agccagtttg tgctgacaca gtccccttcc gcttccgcct ctttaggagc ctccgtgaag     6060

ctgacttgta ctttaagcag cgcccacaaa acctacacca tcgactggta ccagcagcag     6120

cccgagaagg gcccacgtta tttaatgcaa gttaagtccg acggctccta caccaagggc     6180

accggcgtgc ccgatagatt cagcggctcc agcagcggcg ccgataggta tttaaccatc     6240

tcctctttac agagcgagga cgaggccgac tactactgtg gcgccgacga caacggcggc     6300

tacgtgtttg gaggcggcac ccagctgacc gtgctggcta gcggtggcgg aggttctgga     6360

ggtggaggtt cctccggaat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     6420

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     6480

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     6540

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     6600

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     6660

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     6720

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     6780

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     6840

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     6900

ctgccccctc gctaagtcga caatcaacct ctggattaca aaatttgtga aagattgact     6960

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     7020

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     7080

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     7140

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     7200

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     7260

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     7320

acgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     7380

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     7440

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     7500

gcctccccgc ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg     7560

tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac     7620

gaagacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct     7680

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag     7740

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac     7800

ccttttagtc agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt     7860

atttataact tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt     7920

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     7980

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc     8040

tatcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     8100

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     8160

aggctttttt ggaggcctag ctagggacgt acccaattcg ccctatagtg agtcgtatta     8220

cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     8280

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     8340

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     8400

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     8460

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     8520

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     8580

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     8640

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     8700

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     8760

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     8820

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     8880

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     8940

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     9000

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     9060

aaagtaaaag atgctgaaga tcagttgg                                        9088


<210>  112
<211>  9088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  pTRPE-C14-gs-BBz

<400>  112
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatcccaag ttcagctgca agaaagcgga cccggtttag tgaaaccctc cgagacttta     5640

tctttaacat gcgccgtgag cggctacagc atctctcgtc atgctttaac ttggattcgt     5700

cagcctcccg gaaagggttt agagtggatc ggcgccatcg acaacgccgg caccacctat     5760

tacgccagct gggccaagtc tcgtgtgacc atcagcgtgg acaccagcaa gaaccagttc     5820

tctttaaagc tgtccagcgt gaccgctgcc gacacagccg tgtactactg cgctcgtgtg     5880

ttctacgaca tcaacagcgg ctactattta gacggaatgg atctgtgggg ccccggaact     5940

ttagtgacag tcagcagcgg aggcggagga agcggaggag gaggaagctc cggaggcggt     6000

tctcaattcg tgctgacaca gagccctagc gcctctgcct ctttaggagc ctccgtgaag     6060

ctgacttgta ctttaagcag cgcccacaag acctacacca tcgactggta ccagcagcag     6120

cccgagaagg gccctagata tttaatgcaa gttaagagcg acggcagcta caccaaaggc     6180

actggtgtgc ccgatcgttt tagcggcagc agcagcggcg ccgataggta tttaaccatc     6240

agctctttac agagcgagga cgaggccgac tactactgtg gcgccgacga caacggcggc     6300

tacgtgtttg gcggcggcac acagctgacc gttttagcta gcggtggcgg aggttctgga     6360

ggtggaggtt cctccggaat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     6420

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     6480

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     6540

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     6600

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     6660

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     6720

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     6780

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     6840

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     6900

ctgccccctc gctaagtcga caatcaacct ctggattaca aaatttgtga aagattgact     6960

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     7020

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     7080

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     7140

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     7200

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     7260

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     7320

acgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     7380

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     7440

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     7500

gcctccccgc ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg     7560

tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac     7620

gaagacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct     7680

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag     7740

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac     7800

ccttttagtc agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt     7860

atttataact tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt     7920

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     7980

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc     8040

tatcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     8100

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     8160

aggctttttt ggaggcctag ctagggacgt acccaattcg ccctatagtg agtcgtatta     8220

cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     8280

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     8340

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     8400

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     8460

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     8520

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     8580

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     8640

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     8700

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     8760

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     8820

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     8880

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     8940

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     9000

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     9060

aaagtaaaag atgctgaaga tcagttgg                                        9088


<210>  113
<211>  9088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  pTRPE-C25-gs-BBz

<400>  113
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatcccaag ttcagctgca agaaagcgga cccggtttag tgaaaccctc cgagacttta     5640

tctttaacat gcgccgtgag cggctacagc atctctcgtc atgctttaac ttggattcgt     5700

cagcctcccg gaaagggttt agagtggatc ggcgccatcg acaacgccgg caccacctat     5760

tacgccagct gggccaagtc tcgtgtgacc atcagcgtgg acaccagcaa gaaccagttc     5820

tctttaaagc tgtccagcgt gaccgctgcc gacacagccg tgtactactg cgctcgtgtg     5880

ttctacgaca tcaacagcgg ctactattta gacggaatgg atctgtgggg ccccggaact     5940

ttagtgacag tcagcagcgg aggcggagga agcggaggag gaggaagctc cggaggcggt     6000

tctcaactgg tgctgacaca gagccctagc gcctctgcct ctttaggagc ctccgtgaag     6060

ctgacttgta ctttaagcag cgcccacaag acctacacca tcgactggta ccagcagcag     6120

cccgagaagg gccctagata tttaatgcaa gttaagagcg acggcagcta caccaaaggc     6180

actggtgtgc ccgatcgttt tagcggcagc agcagcggcg ccgataggta tttaaccatc     6240

agctctttac agagcgagga cgaggccgac tactactgtg gcgccgacga caacggcggc     6300

tacgtgtttg gcggcggcac acagctgacc gttttagcta gcggtggcgg aggttctgga     6360

ggtggaggtt cctccggaat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     6420

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     6480

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     6540

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     6600

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     6660

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     6720

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     6780

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     6840

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     6900

ctgccccctc gctaagtcga caatcaacct ctggattaca aaatttgtga aagattgact     6960

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     7020

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     7080

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     7140

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     7200

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     7260

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     7320

acgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     7380

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     7440

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     7500

gcctccccgc ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg     7560

tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac     7620

gaagacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct     7680

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag     7740

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac     7800

ccttttagtc agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt     7860

atttataact tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt     7920

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     7980

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc     8040

tatcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     8100

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     8160

aggctttttt ggaggcctag ctagggacgt acccaattcg ccctatagtg agtcgtatta     8220

cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     8280

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     8340

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     8400

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     8460

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     8520

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     8580

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     8640

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     8700

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     8760

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     8820

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     8880

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     8940

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     9000

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     9060

aaagtaaaag atgctgaaga tcagttgg                                        9088


<210>  114
<211>  9088
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  pTRPE-C29-gs-BBz

<400>  114
gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt gagagttttc       60

gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt ggcgcggtat      120

tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat tctcagaatg      180

acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg acagtaagag      240

aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta cttctgacaa      300

cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat catgtaactc      360

gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag cgtgacacca      420

cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa ctacttactc      480

tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca ggaccacttc      540

tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc ggtgagcgtg      600

ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt atcgtagtta      660

tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc gctgagatag      720

gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat atactttaga      780

ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt tttgataatc      840

tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac cccgtagaaa      900

agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc ttgcaaacaa      960

aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca actctttttc     1020

cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgttcttcta gtgtagccgt     1080

agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct ctgctaatcc     1140

tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg gactcaagac     1200

gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc acacagccca     1260

gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta tgagaaagcg     1320

ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg gtcggaacag     1380

gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt cctgtcgggt     1440

ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg cggagcctat     1500

ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg ccttttgctc     1560

acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc gcctttgagt     1620

gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg agcgaggaag     1680

cggaagagcg cccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     1740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     1800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     1860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaccat gattacgcca     1920

agcgcgcaat taaccctcac taaagggaac aaaagctgga gctgcaagct taatgtagtc     1980

ttatgcaata ctcttgtagt cttgcaacat ggtaacgatg agttagcaac atgccttaca     2040

aggagagaaa aagcaccgtg catgccgatt ggtggaagta aggtggtacg atcgtgcctt     2100

attaggaagg caacagacgg gtctgacatg gattggacga accactgaat tgccgcattg     2160

cagagatatt gtatttaagt gcctagctcg atacataaac gggtctctct ggttagacca     2220

gatctgagcc tgggagctct ctggctaact agggaaccca ctgcttaagc ctcaataaag     2280

cttgccttga gtgcttcaag tagtgtgtgc ccgtctgttg tgtgactctg gtaactagag     2340

atccctcaga cccttttagt cagtgtggaa aatctctagc agtggcgccc gaacagggac     2400

ttgaaagcga aagggaaacc agaggagctc tctcgacgca ggactcggct tgctgaagcg     2460

cgcacggcaa gaggcgaggg gcggcgactg gtgagtacgc caaaaatttt gactagcgga     2520

ggctagaagg agagagatgg gtgcgagagc gtcagtatta agcgggggag aattagatcg     2580

cgatgggaaa aaattcggtt aaggccaggg ggaaagaaaa aatataaatt aaaacatata     2640

gtatgggcaa gcagggagct agaacgattc gcagttaatc ctggcctgtt agaaacatca     2700

gaaggctgta gacaaatact gggacagcta caaccatccc ttcagacagg atcagaagaa     2760

cttagatcat tatataatac agtagcaacc ctctattgtg tgcatcaaag gatagagata     2820

aaagacacca aggaagcttt agacaagata gaggaagagc aaaacaaaag taagaccacc     2880

gcacagcaag cggccgctga tcttcagacc tggaggagga gatatgaggg acaattggag     2940

aagtgaatta tataaatata aagtagtaaa aattgaacca ttaggagtag cacccaccaa     3000

ggcaaagaga agagtggtgc agagagaaaa aagagcagtg ggaataggag ctttgttcct     3060

tgggttcttg ggagcagcag gaagcactat gggcgcagcg tcaatgacgc tgacggtaca     3120

ggccagacaa ttattgtctg gtatagtgca gcagcagaac aatttgctga gggctattga     3180

ggcgcaacag catctgttgc aactcacagt ctggggcatc aagcagctcc aggcaagaat     3240

cctggctgtg gaaagatacc taaaggatca acagctcctg gggatttggg gttgctctgg     3300

aaaactcatt tgcaccactg ctgtgccttg gaatgctagt tggagtaata aatctctgga     3360

acagatttgg aatcacacga cctggatgga gtgggacaga gaaattaaca attacacaag     3420

cttaatacac tccttaattg aagaatcgca aaaccagcaa gaaaagaatg aacaagaatt     3480

attggaatta gataaatggg caagtttgtg gaattggttt aacataacaa attggctgtg     3540

gtatataaaa ttattcataa tgatagtagg aggcttggta ggtttaagaa tagtttttgc     3600

tgtactttct atagtgaata gagttaggca gggatattca ccattatcgt ttcagaccca     3660

cctcccaacc ccgaggggac ccgacaggcc cgaaggaata gaagaagaag gtggagagag     3720

agacagagac agatccattc gattagtgaa cggatctcga cggtatcgat tagactgtag     3780

cccaggaata tggcagctag attgtacaca tttagaagga aaagttatct tggtagcagt     3840

tcatgtagcc agtggatata tagaagcaga agtaattcca gcagagacag ggcaagaaac     3900

agcatacttc ctcttaaaat tagcaggaag atggccagta aaaacagtac atacagacaa     3960

tggcagcaat ttcaccagta ctacagttaa ggccgcctgt tggtgggcgg ggatcaagca     4020

ggaatttggc attccctaca atccccaaag tcaaggagta atagaatcta tgaataaaga     4080

attaaagaaa attataggac aggtaagaga tcaggctgaa catcttaaga cagcagtaca     4140

aatggcagta ttcatccaca attttaaaag aaaagggggg attggggggt acagtgcagg     4200

ggaaagaata gtagacataa tagcaacaga catacaaact aaagaattac aaaaacaaat     4260

tacaaaaatt caaaattttc gggtttatta cagggacagc agagatccag tttggctgca     4320

tacgcgtcgt gaggctccgg tgcccgtcag tgggcagagc gcacatcgcc cacagtcccc     4380

gagaagttgg ggggaggggt cggcaattga accggtgcct agagaaggtg gcgcggggta     4440

aactgggaaa gtgatgtcgt gtactggctc cgcctttttc ccgagggtgg gggagaaccg     4500

tatataagtg cagtagtcgc cgtgaacgtt ctttttcgca acgggtttgc cgccagaaca     4560

caggtaagtg ccgtgtgtgg ttcccgcggg cctggcctct ttacgggtta tggcccttgc     4620

gtgccttgaa ttacttccac ctggctgcag tacgtgattc ttgatcccga gcttcgggtt     4680

ggaagtgggt gggagagttc gaggccttgc gcttaaggag ccccttcgcc tcgtgcttga     4740

gttgaggcct ggcctgggcg ctggggccgc cgcgtgcgaa tctggtggca ccttcgcgcc     4800

tgtctcgctg ctttcgataa gtctctagcc atttaaaatt tttgatgacc tgctgcgacg     4860

ctttttttct ggcaagatag tcttgtaaat gcgggccaag atctgcacac tggtatttcg     4920

gtttttgggg ccgcgggcgg cgacggggcc cgtgcgtccc agcgcacatg ttcggcgagg     4980

cggggcctgc gagcgcggcc accgagaatc ggacgggggt agtctcaagc tggccggcct     5040

gctctggtgc ctggcctcgc gccgccgtgt atcgccccgc cctgggcggc aaggctggcc     5100

cggtcggcac cagttgcgtg agcggaaaga tggccgcttc ccggccctgc tgcagggagc     5160

tcaaaatgga ggacgcggcg ctcgggagag cgggcgggtg agtcacccac acaaaggaaa     5220

agggcctttc cgtcctcagc cgtcgcttca tgtgactcca ctgagtaccg ggcgccgtcc     5280

aggcacctcg attagttctc gtgcttttgg agtacgtcgt ctttaggttg gggggagggg     5340

ttttatgcga tggagtttcc ccacactgag tgggtggaga ctgaagttag gccagcttgg     5400

cacttgatgt aattctcctt ggaatttgcc ctttttgagt ttggatcttg gttcattctc     5460

aagcctcaga cagtggttca aagttttttt cttccatttc aggtgtcgtg agctagagcc     5520

accatggagt ttgggctgag ctggcttttt cttgtggcta ttttaaaagg tgtccagtgc     5580

ggatccgagg tgcagctggt ggagtctgga ggaggactgg tgcaacccgg tggctcttta     5640

agactgagct gcgccgcctc tggcttcacc ttttctcgtc acgctttaac atgggtgaga     5700

caagctcccg gaaagggact ggagtgggtg tccgccatcg acaacgccgg caccacctac     5760

tacgccagct gggccaagag cagattcacc atctctcgtg acaacgccaa gaactcttta     5820

tatttacaga tgaactcttt aagggccgag gacaccgccg tgtactactg cgctcgtgtg     5880

ttctacgaca tcaactccgg ctactattta gacggcatgg atttatgggg acccggtaca     5940

ctggtcacag tgagctctgg aggcggaggt agcggaggcg gaggaagcag cggtggaggc     6000

agccagctgg tgctgacaca gtccccttcc gcttccgcct ctttaggagc ctccgtgaag     6060

ctgacttgta ctttaagcag cgcccacaaa acctacacca tcgactggta ccagcagcag     6120

cccgagaagg gcccacgtta tttaatgcaa gttaagtccg acggctccta caccaagggc     6180

accggcgtgc ccgatagatt cagcggctcc agcagcggcg ccgataggta tttaaccatc     6240

tcctctttac agagcgagga cgaggccgac tactactgtg gcgccgacga caacggcggc     6300

tacgtgtttg gaggcggcac ccagctgacc gtgctggcta gcggtggcgg aggttctgga     6360

ggtggaggtt cctccggaat ctacatctgg gcgcccttgg ccgggacttg tggggtcctt     6420

ctcctgtcac tggttatcac cctttactgc aaacggggca gaaagaaact cctgtatata     6480

ttcaaacaac catttatgag accagtacaa actactcaag aggaagatgg ctgtagctgc     6540

cgatttccag aagaagaaga aggaggatgt gaactgagag tgaagttcag caggagcgca     6600

gacgcccccg cgtaccagca gggccagaac cagctctata acgagctcaa tctaggacga     6660

agagaggagt acgatgtttt ggacaagaga cgtggccggg accctgagat ggggggaaag     6720

ccgagaagga agaaccctca ggaaggcctg tacaatgaac tgcagaaaga taagatggcg     6780

gaggcctaca gtgagattgg gatgaaaggc gagcgccgga ggggcaaggg gcacgatggc     6840

ctttaccagg gtctcagtac agccaccaag gacacctacg acgcccttca catgcaggcc     6900

ctgccccctc gctaagtcga caatcaacct ctggattaca aaatttgtga aagattgact     6960

ggtattctta actatgttgc tccttttacg ctatgtggat acgctgcttt aatgcctttg     7020

tatcatgcta ttgcttcccg tatggctttc attttctcct ccttgtataa atcctggttg     7080

ctgtctcttt atgaggagtt gtggcccgtt gtcaggcaac gtggcgtggt gtgcactgtg     7140

tttgctgacg caacccccac tggttggggc attgccacca cctgtcagct cctttccggg     7200

actttcgctt tccccctccc tattgccacg gcggaactca tcgccgcctg ccttgcccgc     7260

tgctggacag gggctcggct gttgggcact gacaattccg tggtgttgtc ggggaagctg     7320

acgtcctttc cttggctgct cgcctgtgtt gccacctgga ttctgcgcgg gacgtccttc     7380

tgctacgtcc cttcggccct caatccagcg gaccttcctt cccgcggcct gctgccggct     7440

ctgcggcctc ttccgcgtct tcgccttcgc cctcagacga gtcggatctc cctttgggcc     7500

gcctccccgc ctggaattcg agctcggtac ctttaagacc aatgacttac aaggcagctg     7560

tagatcttag ccacttttta aaagaaaagg ggggactgga agggctaatt cactcccaac     7620

gaagacaaga tctgcttttt gcttgtactg ggtctctctg gttagaccag atctgagcct     7680

gggagctctc tggctaacta gggaacccac tgcttaagcc tcaataaagc ttgccttgag     7740

tgcttcaagt agtgtgtgcc cgtctgttgt gtgactctgg taactagaga tccctcagac     7800

ccttttagtc agtgtggaaa atctctagca gtagtagttc atgtcatctt attattcagt     7860

atttataact tgcaaagaaa tgaatatcag agagtgagag gaacttgttt attgcagctt     7920

ataatggtta caaataaagc aatagcatca caaatttcac aaataaagca tttttttcac     7980

tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc tggctctagc     8040

tatcccgccc ctaactccgc ccagttccgc ccattctccg ccccatggct gactaatttt     8100

ttttatttat gcagaggccg aggccgcctc ggcctctgag ctattccaga agtagtgagg     8160

aggctttttt ggaggcctag ctagggacgt acccaattcg ccctatagtg agtcgtatta     8220

cgcgcgctca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     8280

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     8340

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgggacg cgccctgtag     8400

cggcgcatta agcgcggcgg gtgtggtggt tacgcgcagc gtgaccgcta cacttgccag     8460

cgccctagcg cccgctcctt tcgctttctt cccttccttt ctcgccacgt tcgccggctt     8520

tccccgtcaa gctctaaatc gggggctccc tttagggttc cgatttagtg ctttacggca     8580

cctcgacccc aaaaaacttg attagggtga tggttcacgt agtgggccat cgccctgata     8640

gacggttttt cgccctttga cgttggagtc cacgttcttt aatagtggac tcttgttcca     8700

aactggaaca acactcaacc ctatctcggt ctattctttt gatttataag ggattttgcc     8760

gatttcggcc tattggttaa aaaatgagct gatttaacaa aaatttaacg cgaattttaa     8820

caaaatatta acgcttacaa tttaggtggc acttttcggg gaaatgtgcg cggaacccct     8880

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     8940

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     9000

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     9060

aaagtaaaag atgctgaaga tcagttgg                                        9088


<210>  115
<211>  1398
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antigen

<220>
<223>  GFRa1

<400>  115
atgttcctgg ccaccctgta cttcgccctg cctctgctgg acctgctgct gagcgccgaa       60

gtgagcggag gagacagact ggactgcgtg aaggccagcg accaatgtct gaaggagcaa      120

tcctgctcca ccaagtacag gacactcagg cagtgcgtgg ccggaaagga aaccaacttc      180

agcctggcca gcggcctcga agctaaggac gaatgcagga gcgccatgga ggccctgaaa      240

cagaagagcc tgtacaactg caggtgcaag aggggcatga agaaggagaa aaactgcctg      300

aggatctact ggagcatgta tcagagcctc cagggcaacg atctgctgga ggacagcccc      360

tacgagcctg tcaacagcag gctgtccgat atcttcaggg tggtgccttt cattagcgac      420

gtgttccagc aggtggagca catccccaaa ggcaacaatt gtctggacgc tgccaaagct      480

tgcaacctcg atgacatctg taagaaatac aggagcgcct acatcacccc ctgcaccaca      540

tccgtgagca atgacgtgtg taacaggagg aagtgccaca aagctctgag gcagttcttc      600

gacaaggtgc ctgccaagca cagctacgga atgctctttt gcagctgcag agacatcgcc      660

tgtaccgaga ggaggagaca aaccatcgtg cccgtgtgct cctatgaaga gagggagaaa      720

cccaactgcc tgaatctgca ggacagctgc aagaccaact acatctgcag gagcaggctg      780

gccgacttct tcaccaattg tcagcccgaa tccagatccg tgagctcctg cctgaaagag      840

aattatgccg actgcctgct ggcttacagc ggactgatcg gcacagtcat gacacccaac      900

tacatcgaca gctcctccct gtccgtggcc ccttggtgcg attgctccaa ctccggcaac      960

gacctggagg agtgtctgaa gttcctgaac ttcttcaagg acaatacctg cctcaagaac     1020

gccatccagg ctttcggaaa cggcagcgac gtgaccgtgt ggcagcccgc ctttcccgtg     1080

cagaccacca cagctaccac aaccaccgcc ctgagggtga agaataagcc tctgggcccc     1140

gccggcagcg agaatgagat ccccacacac gtgctgcctc cttgtgccaa tctccaggcc     1200

cagaagctga agtccaacgt gagcggcaat acccacctct gcatctccaa tggcaactac     1260

gagaaggagg gactgggagc cagcagccac attaccacca aatccatggc tgcccctccc     1320

agctgtggac tgagccctct cctcgtgctg gtggtcaccg ccctgtccac actgctgtcc     1380

ctcaccgaga ccagctga                                                   1398


<210>  116
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antigen

<220>
<223>  GFRa2

<400>  116
atgatcctcg ccaacgtgtt ctgcctgttc tttttcctgg acgagaccct gagaagcctg       60

gctagcccct ccagcctcca gggacctgaa ctgcacggct ggaggccccc tgtggattgc      120

gtgagagcca acgagctgtg cgccgccgag agcaactgtt ccagcagata caggaccctc      180

agacagtgcc tggccggcag agacagaaac accatgctgg ccaacaagga gtgtcaggcc      240

gccctggaag tgctgcaaga gtcccctctg tacgattgta ggtgcaagag gggcatgaag      300

aaggaactgc agtgcctgca gatctattgg agcatccatc tgggcctcac cgagggcgaa      360

gaattttatg aggccagccc ctacgagccc gtgacctcca gactcagcga catcttcagg      420

ctcgcttcca tcttcagcgg cacaggcgcc gatcctgtgg tgagcgccaa gagcaaccat      480

tgcctggacg ctgccaaggc ctgcaacctc aacgacaact gcaagaagct caggagctcc      540

tatatcagca tttgcaacag ggagatttcc cccaccgaga ggtgtaacag gagaaagtgc      600

cacaaggccc tgagacagtt cttcgacaga gtgccttccg agtacaccta caggatgctc      660

ttctgcagct gccaggacca agcctgcgct gagagaagga ggcagaccat cctgccctcc      720

tgcagctacg aagacaagga gaagcctaac tgcctggatc tcaggggcgt ctgcagaacc      780

gaccacctct gtaggtccag actggccgac ttccacgcca attgcagggc cagctaccaa      840

accgtgacca gctgccccgc cgacaactat caggcctgcc tgggcagcta cgccggcatg      900

attggcttcg acatgacccc caattacgtt gatagctccc ccacaggcat cgtggtgagc      960

ccttggtgca gctgcagggg cagcggcaac atggaggaag agtgcgagaa gttcctgagg     1020

gacttcaccg agaatccctg cctgagaaac gccatccagg ccttcggcaa cggcacagac     1080

gtgaacgtgt cccccaaagg ccccagcttt caggccaccc aagctcccag ggtcgagaaa     1140

accccttccc tgcccgacga cctgagcgat tccacatccc tcggcacctc cgtgatcacc     1200

acctgcacat ccgtgcagga acagggcctg aaggccaata actccaagga gctgagcatg     1260

tgcttcacag agctgaccac caacattatc cccggcagca acaaggtgat caagcccaat     1320

tccggaccta gcagagccag acccagcgcc gctctgacag tgctgtccgt gctgatgctg     1380

aaactggccc tgtga                                                      1395


<210>  117
<211>  1203
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antigen

<220>
<223>  GFRa3

<400>  117
atggtgaggc ctctgaatcc cagacccctg cctcccgtgg tgctgatgct gctgctgctg       60

ctccctccct cccctctgcc cctggccgct ggagatcctc tgcccacaga gagcagactc      120

atgaacagct gcctccaggc caggagaaag tgccaggccg accctacctg ttccgccgcc      180

taccaccacc tggactcctg caccagcagc atcagcaccc ctctgcccag cgaagaaccc      240

tccgtccccg ctgattgcct ggaagccgcc cagcagctga gaaatagcag cctgatcggc      300

tgcatgtgcc acagaaggat gaagaaccag gtggcctgcc tggatattta ctggaccgtc      360

cacagggcca gaagcctggg aaattacgaa ctggacgtgt ccccctacga ggacacagtg      420

acaagcaagc cctggaagat gaacctcagc aagctgaaca tgctcaagcc cgacagcgac      480

ctgtgcctca aattcgccat gctgtgcacc ctgaacgaca agtgcgacag gctgaggaaa      540

gcctacggag aagcctgtag cggcccccat tgccagaggc acgtgtgcct gagacagctg      600

ctgaccttct tcgagaaggc cgctgagcct cacgcccaag gactgctcct gtgcccttgc      660

gcccccaatg ataggggctg cggcgagagg agaagaaaca ccatcgctcc caactgcgcc      720

ctgccccctg tggcccctaa ttgcctcgag ctgagaagac tgtgcttctc cgaccctctg      780

tgcaggagca gactggtgga tttccagacc cactgtcacc ccatggacat cctcggaacc      840

tgcgccaccg agcagagcag gtgtctcaga gcctacctgg gcctgatcgg caccgccatg      900

acccccaatt ttgtgagcaa cgtgaacacc tccgtggccc tgtcctgtac ctgcagggga      960

agcggcaacc tccaggagga gtgcgagatg ctcgagggct tcttctccca caatccctgc     1020

ctgaccgagg ccatcgccgc caagatgagg ttccacagcc agctgttctc ccaggattgg     1080

ccccacccca ccttcgctgt gatggcccac cagaacgaaa accccgctgt gagaccccag     1140

ccttgggtgc cctccctgtt cagctgcacc ctgcctctca tcctgctgct gagcctgtgg     1200

tga                                                                   1203


<210>  118
<211>  465
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigen

<220>
<223>  GFRa4 isoform a

<400>  118

Asn Arg Cys Val Asp Ala Ala Glu Ala Cys Thr Ala Asp Ala Arg Cys 
1               5                   10                  15      


Gln Arg Leu Arg Ser Glu Tyr Val Ala Gln Cys Leu Gly Arg Ala Ala 
            20                  25                  30          


Gln Gly Gly Cys Pro Arg Ala Arg Cys Arg Arg Ala Leu Arg Arg Phe 
        35                  40                  45              


Phe Ala Arg Gly Pro Pro Ala Leu Thr His Ala Leu Leu Phe Cys Pro 
    50                  55                  60                  


Cys Ala Gly Pro Ala Cys Ala Glu Arg Arg Arg Gln Thr Phe Val Pro 
65                  70                  75                  80  


Ser Cys Ala Phe Ser Gly Pro Gly Pro Ala Pro Pro Ser Cys Leu Glu 
                85                  90                  95      


Pro Leu Asn Phe Cys Glu Arg Ser Arg Val Cys Arg Pro Arg Leu Leu 
            100                 105                 110         


Ala Phe Gln Val Ser Cys Thr Pro Ala Pro Ser Ala Pro Asp Gly Cys 
        115                 120                 125             


Leu Leu Asp Gln Gly Ala Arg Cys Leu Arg Ala Tyr Ala Gly Leu Val 
    130                 135                 140                 


Gly Thr Ala Val Thr Pro Asn Tyr Val Asp Asn Val Ser Ala Arg Val 
145                 150                 155                 160 


Ala Pro Trp Cys Asp Cys Gly Ala Ser Gly Asn Arg Arg Glu Asp Cys 
                165                 170                 175     


Glu Ala Phe Arg Gly Leu Phe Thr Arg Asn Arg Cys Leu Asp Gly Ala 
            180                 185                 190         


Ile Gln Ala Phe Ala Ser Gly Trp Pro Pro Val Leu Leu Asp Gln Leu 
        195                 200                 205             


Asn Pro Gln Gly Asp Pro Glu His Ser Leu Leu Gln Val Ser Ile Glu 
    210                 215                 220                 


Gly Arg Met Asp Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
        355                 360                 365             


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys His His His His His 
    450                 455                 460                 


His 
465 


<210>  119
<211>  497
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Antigen

<220>
<223>  GFRa4 isoform b

<400>  119

Asn Arg Cys Val Asp Ala Ala Glu Ala Cys Thr Ala Asp Ala Arg Cys 
1               5                   10                  15      


Gln Arg Leu Arg Ser Glu Tyr Val Ala Gln Cys Leu Gly Arg Ala Ala 
            20                  25                  30          


Gln Gly Gly Cys Pro Arg Ala Arg Cys Arg Arg Ala Leu Arg Arg Phe 
        35                  40                  45              


Phe Ala Arg Gly Pro Pro Ala Leu Thr His Ala Leu Leu Phe Cys Pro 
    50                  55                  60                  


Cys Ala Gly Pro Ala Cys Ala Glu Arg Arg Arg Gln Thr Phe Val Pro 
65                  70                  75                  80  


Ser Cys Ala Phe Ser Gly Pro Gly Pro Ala Pro Pro Ser Cys Leu Glu 
                85                  90                  95      


Pro Leu Asn Phe Cys Glu Arg Ser Arg Val Cys Arg Cys Ala Arg Ala 
            100                 105                 110         


Ala Ala Gly Pro Trp Arg Gly Trp Gly Arg Gly Leu Ser Pro Ala His 
        115                 120                 125             


Arg Pro Pro Ala Ala Gln Ala Ser Pro Pro Gly Leu Ser Gly Leu Val 
    130                 135                 140                 


His Pro Ser Ala Gln Arg Pro Arg Arg Leu Pro Ala Gly Pro Gly Arg 
145                 150                 155                 160 


Pro Leu Pro Ala Arg Leu Arg Gly Pro Arg Gly Val Pro Ala Gly Thr 
                165                 170                 175     


Ala Val Thr Pro Asn Tyr Val Asp Asn Val Ser Ala Arg Val Ala Pro 
            180                 185                 190         


Trp Cys Asp Cys Gly Ala Ser Gly Asn Arg Arg Glu Asp Cys Glu Ala 
        195                 200                 205             


Phe Arg Gly Leu Phe Thr Arg Asn Arg Cys Leu Asp Gly Ala Ile Gln 
    210                 215                 220                 


Ala Phe Ala Ser Gly Trp Pro Pro Val Leu Leu Asp Gln Leu Asn Pro 
225                 230                 235                 240 


Gln Gly Asp Pro Glu His Ser Leu Leu Gln Val Gly Gly Gly Glu Asn 
                245                 250                 255     


Leu Tyr Phe Gln Gly Gly Gly Gly Gly Ala Gly Gly Gly Gly Asp Lys 
            260                 265                 270         


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
        275                 280                 285             


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
    290                 295                 300                 


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
305                 310                 315                 320 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
                325                 330                 335     


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
            340                 345                 350         


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
        355                 360                 365             


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
    370                 375                 380                 


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
385                 390                 395                 400 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
                405                 410                 415     


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
            420                 425                 430         


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
        435                 440                 445             


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
    450                 455                 460                 


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
465                 470                 475                 480 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
                485                 490                 495     


Lys 
    


<210>  120
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  Fig2A

<400>  120

Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr Leu Thr 
1               5                   10                  15      


Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg His Ala Leu Thr 
            20                  25                  30          


Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly Ala Ile 
        35                  40                  45              


Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser Arg Ser 
    50                  55                  60                  


Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr Leu Lys Met Thr 
65                  70                  75                  80  


Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  


<210>  121
<211>  94
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV4-38-2*02

<400>  121

Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
1               5                   10                  15      


Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Ser Ser Gly Tyr Tyr Trp 
            20                  25                  30          


Gly Val Ile Gln Ala Pro Gly Asn Lys Leu Glu Trp Ile Gly Ser Ile 
        35                  40                  45              


Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val 
    50                  55                  60                  


Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser 
65                  70                  75                  80  


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  


<210>  122
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV4-59*05

<400>  122

Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
1               5                   10                  15      


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
            20                  25                  30          


Val Ile Gln Ala Pro Gly Asn Lys Leu Glu Trp Ile Gly Arg Ile Tyr 
        35                  40                  45              


Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Lys Ser Arg Val Thr 
    50                  55                  60                  


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
65                  70                  75                  80  


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90          


<210>  123
<211>  93
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV4-59*07

<400>  123

Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Asp Thr Leu Ser 
1               5                   10                  15      


Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr Tyr Trp Ser 
            20                  25                  30          


Val Ile Gln Ala Pro Gly Asn Lys Leu Glu Trp Ile Gly Tyr Ile Tyr 
        35                  40                  45              


Tyr Ser Gly Ser Thr Ser Tyr Asn Pro Ala Leu Lys Ser Arg Val Thr 
    50                  55                  60                  


Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser 
65                  70                  75                  80  


Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90              


<210>  124
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  Fig2B

<400>  124

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys 
                85                  90          


<210>  125
<211>  90
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV4-3*01

<400>  125

Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Leu Leu Gly Ala Ser Ile 
1               5                   10                  15      


Lys Leu Thr Cys Thr Leu Ser Ser Glu His Ser Thr Tyr Thr Ile Glu 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Arg Ser Pro Gln Tyr Thr Met Lys Val 
        35                  40                  45              


Lys Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Met Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Phe Ser Asn Leu 
65                  70                  75                  80  


Gln Ser Asp Asp Glu Ala Glu Tyr His Cys 
                85                  90  


<210>  126
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV4-69*01 02

<400>  126

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
                85                  90          


<210>  127
<211>  96
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  Fig3A

<400>  127

Gln Ser Val Lys Glu Ser Glu Gly Gly Leu Phe Lys Pro Thr Asp Thr 
1               5                   10                  15      


Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Arg His Ala 
            20                  25                  30          


Leu Thr Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile Gly 
        35                  40                  45              


Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
    50                  55                  60                  


Arg Ser Thr Ile Thr Arg Asn Thr Asp Leu His Thr Val Thr Leu Lys 
65                  70                  75                  80  


Met Thr Ser Leu Thr Ala Ser Asp Thr Ala Thr Tyr Phe Cys Ala Arg 
                85                  90                  95      


<210>  128
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV-38-2*02

<400>  128

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Ser Gly 
            20                  25                  30          


Tyr Tyr Trp Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Gly Ser Ile Tyr His Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  129
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV-48*03

<400>  129

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  130
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  Fig3B

<400>  130

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr 
            100 


<210>  131
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  Fig3B

<400>  131

Gln Phe Val Leu Thr Gln Ser Pro Ser Val Ser Ala Ala Leu Gly Ala 
1               5                   10                  15      


Ser Ala Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Gln Gly Glu Ala Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ile Ile Pro 
65                  70                  75                  80  


Ser Val Gln Ala Asp Asp Glu Ala Gly Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  132
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV4-69*01

<400>  132

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Leu Asn Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly 
                85                  90                  95      


Thr Gly Ile 
            


<210>  133
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV1-44*01

<400>  133

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly 
        


<210>  134
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV2-14*01

<400>  134

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Asn Arg Pro Ser Gly Val Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Thr Ser Ser 
                85                  90                  95      


Ser Thr Leu 
            


<210>  135
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  IGLV4-3*01

<400>  135

Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Leu Leu Gly Ala Ser Ile 
1               5                   10                  15      


Lys Leu Thr Cys Thr Leu Ser Ser Glu His Ser Thr Tyr Thr Ile Glu 
            20                  25                  30          


Trp Tyr Gln Gln Arg Pro Gly Arg Ser Pro Gln Tyr Ile Met Lys Val 
        35                  40                  45              


Lys Ser Asp Gly Ser His Ser Lys Gly Asp Gly Ile Pro Asp Arg Phe 
    50                  55                  60                  


Met Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Phe Ser Asn Leu 
65                  70                  75                  80  


Gln Ser Asp Asp Glu Ala Glu Tyr His Cys Gly Glu Ser His Thr Ile 
                85                  90                  95      


Asp Gly Gln Val Gly 
            100     


<210>  136
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1

<400>  136

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  137
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1m3

<400>  137

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  138
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1m2

<400>  138

Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  139
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H1m1

<400>  139

Gln Gln Ser Val Lys Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Phe Ser Leu Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


<210>  140
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  IGHV3-48*03

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg 
        


<210>  141
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  142
<211>  97
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy Chain

<220>
<223>  H2m1

<400>  142

Glu Gln Ser Val Lys Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Ser Arg His 
            20                  25                  30          


Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Arg Asn Thr Asp Leu His Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg 
    


<210>  143
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1

<400>  143

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Lys Val Lys Ser Asp Gly Ser Tyr Ser Lys Gly Asp Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  144
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m2

<400>  144

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Glu Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  145
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m4

<400>  145

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Ala Trp His Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  146
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m3

<400>  146

Gln Leu Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  147
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L1m1

<400>  147

Gln Phe Val Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  148
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2

<400>  148

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  149
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m3

<400>  149

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  150
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m2

<400>  150

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Ala Ser Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  151
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L2m1

<400>  151

Gln Phe Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Ala Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  152
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3

<400>  152

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Asn Arg Pro Ser Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  153
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m3

<400>  153

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  154
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m5

<400>  154

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Tyr Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  155
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m4

<400>  155

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  156
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m2

<400>  156

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Met Ile 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Ser Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  157
<211>  101
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light Chain

<220>
<223>  L3m1

<400>  157

Gln Phe Val Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr 
            20                  25                  30          


Ile Asp Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Tyr Leu Met 
        35                  40                  45              


Gln Val Lys Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asn 
    50                  55                  60                  


Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 
65                  70                  75                  80  


Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Val Cys Gly Ala Asp Asp 
                85                  90                  95      


Asn Gly Gly Tyr Val 
            100     


<210>  158
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  CAR10

<400>  158

Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Phe Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys 
145                 150                 155                 160 


Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp 
                165                 170                 175     


Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys 
            180                 185                 190         


Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly 
225                 230                 235                 240 


Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ala Ser 
                245                 250                 


<210>  159
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  CAR14

<400>  159

Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
            20                  25                  30          


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Phe Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys 
145                 150                 155                 160 


Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp 
                165                 170                 175     


Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys 
            180                 185                 190         


Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly 
225                 230                 235                 240 


Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ala Ser 
                245                 250                 


<210>  160
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  CAR25

<400>  160

Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro 
1               5                   10                  15      


Ser Glu Thr Leu Ser Leu Thr Cys Ala Val Ser Gly Tyr Ser Ile Ser 
            20                  25                  30          


Arg His Ala Leu Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Leu Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys 
145                 150                 155                 160 


Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp 
                165                 170                 175     


Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys 
            180                 185                 190         


Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly 
225                 230                 235                 240 


Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ala Ser 
                245                 250                 


<210>  161
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CAR

<220>
<223>  CAR29

<400>  161

Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Arg His Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp 
    50                  55                  60                  


Ala Lys Ser Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly 
            100                 105                 110         


Met Asp Leu Trp Gly Pro Gly Thr Leu Val Thr Val Ser Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Ser Gly Gly Gly Ser Gln Leu Val 
    130                 135                 140                 


Leu Thr Gln Ser Pro Ser Ala Ser Ala Ser Leu Gly Ala Ser Val Lys 
145                 150                 155                 160 


Leu Thr Cys Thr Leu Ser Ser Ala His Lys Thr Tyr Thr Ile Asp Trp 
                165                 170                 175     


Tyr Gln Gln Gln Pro Glu Lys Gly Pro Arg Tyr Leu Met Gln Val Lys 
            180                 185                 190         


Ser Asp Gly Ser Tyr Thr Lys Gly Thr Gly Val Pro Asp Arg Phe Ser 
        195                 200                 205             


Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser Ser Leu Gln 
    210                 215                 220                 


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gly Ala Asp Asp Asn Gly Gly 
225                 230                 235                 240 


Tyr Val Phe Gly Gly Gly Thr Gln Leu Thr Val Leu Ala Ser 
                245                 250                 


<210>  162
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  HCDR1

<400>  162

Arg His Ala Leu Thr 
1               5   


<210>  163
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  HCDR2

<400>  163

Ala Ile Asp Asn Ala Gly Thr Thr Tyr Tyr Ala Ser Trp Ala Lys Ser 
1               5                   10                  15      


<210>  164
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  HCDR3

<400>  164

Val Phe Tyr Asp Ile Asn Ser Gly Tyr Tyr Leu Asp Gly Met Asp Leu 
1               5                   10                  15      


<210>  165
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  LCDR1

<400>  165

Ser Ala His Lys Thr Tyr Thr 
1               5           


<210>  166
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  LCDR2

<400>  166

Val Lys Ser Asp Gly Ser Tyr 
1               5           


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDR

<220>
<223>  LCDR3

<400>  167

Gly Ala Asp Asp Asn Gly Gly Tyr Val 
1               5                   


<210>  168
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  GS-linker

<400>  168

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  169
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<220>
<223>  GS-linker

<400>  169

Gly Gly Ser Ser Arg Ser Ser Ser Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly 
        


