                         SEQUENCE LISTING

<110>  Catalent Pharma Solutions
       Rabuka, David
       Drake, Penelope M
 
<120>  ANTI-CD25 ANTIBODY-MAYTANSINE CONJUGATES AND METHODS OF USE 
       THEREOF

<130>  RDWD-033WO

<140>  PCT/US2019/054753
<141>  2019-10-04

<160>  174   

<170>  PatentIn version 3.5

<210>  1
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  1

Glu Leu Cys Asp Asp Asp Pro Pro Glu Ile Pro His Ala Thr Phe Lys 
1               5                   10                  15      


Ala Met Ala Tyr Lys Glu Gly Thr Met Leu Asn Cys Glu Cys Lys Arg 
            20                  25                  30          


Gly Phe Arg Arg Ile Lys Ser Gly Ser Leu Tyr Met Leu Cys Thr Gly 
        35                  40                  45              


Asn Ser Ser His Ser Ser Trp Asp Asn Gln Cys Gln Cys Thr Ser Ser 
    50                  55                  60                  


Ala Thr Arg Asn Thr Thr Lys Gln Val Thr Pro Gln Pro Glu Glu Gln 
65                  70                  75                  80  


Lys Glu Arg Lys Thr Thr Glu Met Gln Ser Pro Met Gln Pro Val Asp 
                85                  90                  95      


Gln Ala Ser Leu Pro Gly His Cys Arg Glu Pro Pro Pro Trp Glu Asn 
            100                 105                 110         


Glu Ala Thr Glu Arg Ile Tyr His Phe Val Val Gly Gln Met Val Tyr 
        115                 120                 125             


Tyr Gln Cys Val Gln Gly Tyr Arg Ala Leu His Arg Gly Pro Ala Glu 
    130                 135                 140                 


Ser Val Cys Lys Met Thr His Gly Lys Thr Arg Trp Thr Gln Pro Gln 
145                 150                 155                 160 


Leu Ile Cys Thr Gly Glu Met Glu Thr Ser Gln Phe Pro Gly Glu Glu 
                165                 170                 175     


Lys Pro Gln Ala Ser Pro Glu Gly Arg Pro Glu Ser Glu Thr Ser Cys 
            180                 185                 190         


Leu Val Thr Thr Thr Asp Phe Gln Ile Gln Thr Glu Met Ala Ala Thr 
        195                 200                 205             


Met Glu Thr Ser Ile Phe Thr Thr Glu Tyr Gln Val Ala Val Ala Gly 
    210                 215                 220                 


Cys Val Phe Leu Leu Ile Ser Val Leu Leu Leu Ser Gly Leu Thr Trp 
225                 230                 235                 240 


Gln Arg Arg Gln Arg Lys Ser Arg Arg Thr Ile 
                245                 250     


<210>  2
<211>  213
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  3
<211>  454
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  3

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Ser Leu Cys 
        435                 440                 445             


Thr Pro Ser Arg Gly Ser 
    450                 


<210>  4
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  4
gacatccaga tgacccagtc tccttccacc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgca gcgccagcag cagtattagt tacatgcact ggtatcagca gaaaccaggg      120

aaagccccta agctcctgat ctataccacc tccaacttgg ccagtggggt cccagccagg      180

ttcagcggca gtggatctgg gacagaattc actctcacca tcagcagcct gcagcctgat      240

gattttgcaa cttattactg ccaccagagg agcacctatc ccctgacttt cggccagggg      300

accaaggtgg aggtgaaacg tactgtggct gcaccatctg tcttcatctt cccgccatct      360

gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc tgctgaataa cttctatccc      420

agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag      480

agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg      540

agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg      600

agctcgcccg tcacaaagag cttcaacagg ggagagtgtt agtga                      645


<210>  5
<211>  1368
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  5
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggagctc agtgaaggtt       60

tcctgcaagg catctggata caccttcacc agctacagga tgcactgggt gcgacaggcc      120

cctggacaag ggcttgagtg gatcggatac atcaacccta gtaccggtta cacagagtac      180

aaccagaagt tcaaggacaa ggccaccatc accgccgacg agtccacgaa cacagcctac      240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gagaggcgga      300

ggagtgttcg actactgggg ccagggaacc ctggtgaccg tctcctcagc tagcaccaag      360

ggcccatcgg tcttccccct ggcaccctcc tccaagagca cctctggggg cacagcggcc      420

ctgggctgcc tggtcaagga ctacttcccc gaaccggtga cggtgtcgtg gaactcaggc      480

gccctgacca gcggcgtgca caccttcccg gctgtcctac agtcctcagg actctactcc      540

ctcagcagcg tggtgaccgt gccctccagc agcttgggca cccagaccta catctgcaac      600

gtgaatcaca agcccagcaa caccaaggtg gacaagagag ttgagcccaa atcttgtgac      660

aaaactcaca catgcccacc gtgcccagca cctgaactcc tggggggacc gtcagtcttc      720

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      780

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      840

gtggaggtgc ataatgccaa gacaaagcca agagaggagc agtacaacag cacgtaccgt      900

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      960

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg     1020

cagccccgag aaccacaggt gtacaccctg cccccatccc gggaggagat gaccaagaac     1080

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg     1140

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac     1200

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac     1260

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1320

tccctgtctc ccgggtcctt atgtacccct tctagaggat cctgatga                  1368


<210>  6
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  6

Ser Tyr Arg Met His 
1               5   


<210>  7
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  7

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  8
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  8

Gly Gly Gly Val Phe Asp Tyr 
1               5           


<210>  9
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  9

Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210>  10
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  10

Tyr Thr Ser Ile Leu His Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  11

Gln Gln Gly Asn Thr Leu Pro Trp Thr 
1               5                   


<210>  12
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  13
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  14
<211>  116
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  15
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  15

Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Thr Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Asp 
65                  70                  75                  80  


Asp Phe Ala Thr Tyr Tyr Cys His Gln Arg Ser Thr Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Val Lys 
            100                 105     


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  16

Leu Cys Thr Pro Ser Arg 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  17

Met Cys Thr Pro Ser Arg 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  18

Val Cys Thr Pro Ser Arg 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  19

Leu Cys Ser Pro Ser Arg 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  20

Leu Cys Ala Pro Ser Arg 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  21

Leu Cys Val Pro Ser Arg 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  22

Leu Cys Gly Pro Ser Arg 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  23

Ile Cys Thr Pro Ala Arg 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  24

Leu Cys Thr Pro Ser Lys 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  25

Met Cys Thr Pro Ser Lys 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  26

Val Cys Thr Pro Ser Lys 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  27

Leu Cys Ser Pro Ser Lys 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  28

Leu Cys Ala Pro Ser Lys 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  29

Leu Cys Val Pro Ser Lys 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  30

Leu Cys Gly Pro Ser Lys 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  31

Leu Cys Thr Pro Ser Ala 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  32

Ile Cys Thr Pro Ala Ala 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  33

Met Cys Thr Pro Ser Ala 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  34

Val Cys Thr Pro Ser Ala 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  35

Leu Cys Ser Pro Ser Ala 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  36

Leu Cys Ala Pro Ser Ala 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  37

Leu Cys Val Pro Ser Ala 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  38

Leu Cys Gly Pro Ser Ala 
1               5       


<210>  39
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa at position 10 is the modified amino acid residue of formula 
       I.

<400>  39

Ser Leu Ser Leu Ser Pro Gly Ser Leu Xaa Thr Pro Ser Arg Gly Ser 
1               5                   10                  15      


<210>  40
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  40

Ser Leu Ser Leu Ser Pro Gly Lys 
1               5               


<210>  41
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid, with the proviso that when the sulfatase motif
       is at the N-terminus of the target polypeptide, X1 is present.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is the modified amino acid residue of formula 
       (I).

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 can be any amino acid, e.g., an aliphatic amino
       acid, a sulfur-containing amino acid, or a polar, uncharged amino
       acid, (i.e., other than an aromatic amino acid or a charged amino
       acid), e.g., S, T, A, V, G or C, e.g., S, T, A, V or G.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is either a proline or alanine residue.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is can be any amino acid, e.g., an aliphatic 
       amino acid, a sulfur-containing amino acid, or a polar, uncharged
       amino acid, (i.e., other than an aromatic amino acid or a charged
       amino acid), e.g., S, T, A, V, G or C, e.g., S, T, A, V or G.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is a basic amino acid (e.g., arginine (R), and 
       may be lysine (K) or histidine (H), usually lysine), or an 
       aliphatic amino acid (alanine (A), glycine (G), leucine (L), 
       valine (V), isoleucine (I), or proline (P), e.g., A, G, L, V, or 
       

<400>  41

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  42

Lys Val Asp Asn Ala Leu 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  43

Gln Ser Gly Asn Ser Gln 
1               5       


<210>  44
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is the modified amino acid residue of formula 
       (I).

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  44

Lys Val Asp Asn Ala Leu Xaa Thr Pro Ser Arg Gln Ser Gly Asn Ser 
1               5                   10                  15      


Gln 
    


<210>  45
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  45

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  46

Ser Trp Asn Ser Gly Ala 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  47

Gly Val His Thr Phe Pro 
1               5       


<210>  48
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa at position 8 is the modified amino acid residue of formula 
       (I).

<400>  48

Ser Trp Asn Ser Gly Ala Leu Xaa Thr Pro Ser Arg Gly Val His Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  49
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  49

Ala Ser Thr Lys Gly Pro 
1               5       


<210>  50
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  50

Lys Ser Thr Ser Gly Gly Thr 
1               5           


<210>  51
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  51

Pro Glu Pro Val 
1               


<210>  52
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  52

Asn Ser Gly Ala Leu Thr Ser Gly 
1               5               


<210>  53
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  53

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
1               5                   10                  15      


Gln Ser Ser Gly Leu 
            20      


<210>  54
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  54

Gln Ser Ser Gly Leu 
1               5   


<210>  55
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  55

Thr Gln Thr Tyr 
1               


<210>  56
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  56

His Lys Pro Ser Asn 
1               5   


<210>  57
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  57

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly 
            20          


<210>  58
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  58

Phe Pro Pro Lys Pro 
1               5   


<210>  59
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  59

Ile Ser Arg Thr Pro 
1               5   


<210>  60
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  60

Asp Val Ser His Glu Asp Pro Glu Val 
1               5                   


<210>  61
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  61

Ser His Glu Asp Pro Glu Val 
1               5           


<210>  62
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  62

Asp Gly Val Glu Val His Asn Ala Lys 
1               5                   


<210>  63
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  63

Gln Tyr Asn Ser Thr 
1               5   


<210>  64
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  64

Val Leu Thr Val Leu 
1               5   


<210>  65
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  65

Asn Lys Ala Leu Pro Ala Pro 
1               5           


<210>  66
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  66

Ser Lys Ala Lys Gly Gln Pro Arg Glu 
1               5                   


<210>  67
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  67

Lys Ala Lys Gly Gln Pro Arg 
1               5           


<210>  68
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  68

Pro Pro Ser Arg Lys Glu Leu Thr Lys Asn 
1               5                   10  


<210>  69
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  69

Tyr Pro Ser Asp Ile 
1               5   


<210>  70
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  70

Asn Gly Gln Pro Glu Asn Asn 
1               5           


<210>  71
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  71

Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
1               5                   10  


<210>  72
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  72

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Lys 
            


<210>  73
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  73

Ser Leu Ser Pro Gly Lys 
1               5       


<210>  74
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  74

Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
1               5                   10          


<210>  75
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  75

Phe Pro Glu Pro Val 
1               5   


<210>  76
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  76

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
1               5                   10          


<210>  77
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  77

Gln Ser Ser Gly Leu Tyr 
1               5       


<210>  78
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  78

Val Ala Gly Pro Ser 
1               5   


<210>  79
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  79

Val Leu Thr Val Val 
1               5   


<210>  80
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  80

Asn Lys Gly Leu Pro Ala Pro 
1               5           


<210>  81
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  81

Ser Lys Thr Lys Gly Gln Pro Arg Glu 
1               5                   


<210>  82
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  82

Met Thr Lys Asn Gln 
1               5   


<210>  83
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  83

Asn Gly Gln Pro Glu Asn Asn 
1               5           


<210>  84
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  84

Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
1               5                   10  


<210>  85
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  85

Gly Asn Val Phe 
1               


<210>  86
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  86

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
1               5                   10                  15      


Pro Gly Lys 
            


<210>  87
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  87

Pro Cys Ser Arg Ser Thr Ser Gly Gly Thr 
1               5                   10  


<210>  88
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  88

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
1               5                   10                  15      


Ser Ser Gly 
            


<210>  89
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  89

Arg Val Glu Leu Lys Thr Pro Leu Gly Asp 
1               5                   10  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  90

Cys Pro Arg Cys Pro Lys Pro 
1               5           


<210>  91
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  91

Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Ala Pro 
1               5                   10                  15      


Glu Leu Leu Gly Gly 
            20      


<210>  92
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  92

Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
1               5                   10  


<210>  93
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  93

Ser Ser Gly Gln Pro Glu Asn Asn 
1               5               


<210>  94
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  94

Thr Pro Pro Met Leu Asp Ser Asp Gly Ser 
1               5                   10  


<210>  95
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  95

His Glu Ala Leu His Asn Arg 
1               5           


<210>  96
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  96

Ser Thr Lys Gly Pro 
1               5   


<210>  97
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  97

Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser 
1               5                   10      


<210>  98
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  98

Asp Val Ser Gln Glu Asp Pro Glu Val 
1               5                   


<210>  99
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  99

Asn Lys Gly Leu Pro Ser Ser 
1               5           


<210>  100
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  100

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
1               5                   10  


<210>  101
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  101

Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
1               5                   10  


<210>  102
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  102

His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
1               5                   10                  15      


Leu Gly Lys 
            


<210>  103
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  103

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu 
1               5                   10              


<210>  104
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  104

Gln Pro Asp Gly Asn Arg Glu Phe 
1               5               


<210>  105
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  105

Val Gln Gly Phe Phe Pro Gln Glu Pro Leu 
1               5                   10  


<210>  106
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  106

Ser Gly Gln Gly Val Thr Ala Arg Asn Phe Pro 
1               5                   10      


<210>  107
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  107

Ser Gly Asp Leu Tyr Thr Thr 
1               5           


<210>  108
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  108

Pro Ala Thr Gln 
1               


<210>  109
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  109

His Arg Pro Ala 
1               


<210>  110
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  110

Leu Leu Gly Ser Glu 
1               5   


<210>  111
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  111

Gly Leu Arg Asp Ala Ser Gly Val 
1               5               


<210>  112
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  112

Ser Ser Gly Lys Ser Ala Val Gln Gly Pro 
1               5                   10  


<210>  113
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  113

Gly Cys Tyr Ser 
1               


<210>  114
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  114

Cys Ala Glu Pro 
1               


<210>  115
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  115

Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
1               5                   10                  15      


Glu Glu Leu Ala Leu Asn Glu Leu 
            20                  


<210>  116
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  116

Ala Arg Gly Phe Ser 
1               5   


<210>  117
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  117

Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr 
1               5                   10      


<210>  118
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  118

Ala Ala Glu Asp 
1               


<210>  119
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  119

His Glu Ala Leu 
1               


<210>  120
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  120

Ile Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val 
1               5                   10                  15      


Met Ala Glu Val Asp Gly Thr Cys Tyr 
            20                  25  


<210>  121
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  121

Asn Ser Gly Ala Leu Thr Ser Gly 
1               5               


<210>  122
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  122

Asn Ser Gly Ala Leu Cys Thr Pro Ser Arg Gly 
1               5                   10      


<210>  123
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  123

Cys Thr Pro Ser Arg 
1               5   


<210>  124
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  124

Asn Lys Ala Leu Pro Ala Pro 
1               5           


<210>  125
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  125

Asn Leu Cys Thr Pro Ser Arg Ala Pro 
1               5                   


<210>  126
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  126

Lys Ala Lys Gly Leu Cys Thr Pro Ser Arg 
1               5                   10  


<210>  127
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  127

Arg Thr Val Ala Ala Pro 
1               5       


<210>  128
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  128

Tyr Pro Arg Glu Ala 
1               5   


<210>  129
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  129

Pro Arg Glu Ala 
1               


<210>  130
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  130

Asp Asn Ala Leu Gln Ser Gly Asn 
1               5               


<210>  131
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  131

Thr Glu Gln Asp Ser Lys Asp Ser Thr 
1               5                   


<210>  132
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  132

His Gln Gly Leu Ser Ser 
1               5       


<210>  133
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  133

Arg Gly Glu Cys 
1               


<210>  134
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  134

Gln Pro Lys Ala Ala Pro 
1               5       


<210>  135
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  135

Asp Phe Tyr Pro Gly Ala Val 
1               5           


<210>  136
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  136

Asp Ser Ser Pro Val Lys Ala Gly 
1               5               


<210>  137
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  137

Ala Pro Thr Glu Cys Ser 
1               5       


<210>  138
<211>  99
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  138

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu 
            


<210>  139
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  139

Gly Ala Leu Thr Ser Gly Val His 
1               5               


<210>  140
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  140

Gly Ala Leu Cys Thr Pro Ser Arg Gly Val His 
1               5                   10      


<210>  141
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  141

Ser Leu Cys Thr Pro Ser Arg Gly Ser 
1               5                   


<210>  142
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  142

Lys Val Asp Asn Ala Leu Leu Cys Thr Pro Ser Arg Gln Ser Gly Asn 
1               5                   10                  15      


Ser Gln 
        


<210>  143
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid,  (i.e.,other than an aromatic amino acid or a 
       charged amino acid), with the proviso that when the sulfatase 
       motif is at the N-terminus of the target polypeptide, X1 is 
       

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is formylglycine.

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa at position 3 can be any amino acid, e.g., an aliphatic amino
       acid, a sulfur-containing amino acid, or a polar, uncharged amino
       acid, (i.e., other than an aromatic amino acid or a charged amino
       acid), e.g., S, T, A, V, G or C, e.g., S, T, A, V or G.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is either a porline or alanine residue.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 can be any amino acid, e.g., an aliphatic amino
       acid, a sulfur-containing amino acid, or a polar, uncharged amino
       acid, (i.e., other than an aromatic amino acid or a charged amino
       acid), e.g., S, T, A, V, G or C, e.g., S, T, A, V or G.

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is a basic amino acid (e.g., arginine (R), and 
       may be lysine (K) or histidine (H), usually lysine), or an 
       aliphatic amino acid (alanine (A), glycine (G), leucine (L), 
       valine (V), isoleucine (I), or proline (P), e.g., A, G, L, V, or 
       

<400>  143

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  144
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is the modified amino acid residue of formula 
       (I).

<400>  144

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  145
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  145

Ser Leu Ser Leu Ser Pro Gly 
1               5           


<210>  146
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa at position 1 may be present or absent and, when present, can
       be any amino acid, with the proviso that when the sequence is at 
       the N-terminus of the antibody, Xaa is present.

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is formylglycine.

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is a proline or alalnine residue.

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa at position 5 is a basic amino acid or an aliphatic amino 
       acid.

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  146

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  147
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  147

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  148
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is formylglycine.

<400>  148

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  149
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa at position 6 is formylglycine.

<400>  149

Ser Pro Gly Ser Leu Xaa Thr Pro Ser Arg Gly Ser 
1               5                   10          


<210>  150
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  150

Gln Ser Gly Asn Ser Gln 
1               5       


<210>  151
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is formylglycine.

<400>  151

Lys Val Asp Asn Ala Leu Xaa Thr Pro Ser Arg Gln Ser Gly Asn Ser 
1               5                   10                  15      


Gln 
    


<210>  152
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  152

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  153
<211>  18
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  153

Ser Trp Asn Ser Gly Ala Leu Xaa Thr Pro Ser Arg Gly Val His Thr 
1               5                   10                  15      


Phe Pro 
        


<210>  154
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is cysteine or serine.

<400>  154

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  155
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  155

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  156
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  156

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  157
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  157

Xaa Cys Xaa Pro Xaa Xaa 
1               5       


<210>  158
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  158

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
1               5                   10  


<210>  159
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at poisiotn 2 is the modified residue of formula (I).

<400>  159

Leu Xaa Thr Pro Ser Arg 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  160

Gly Val His Thr Phe Pro 
1               5       


<210>  161
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  misc_feature
<222>  (1)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  161

Xaa Xaa Xaa Xaa Xaa Xaa 
1               5       


<210>  162
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  162

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  163
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  163

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
225                 230                 235                 240 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  164
<211>  330
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  164

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  165
<211>  377
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  165

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro 
            100                 105                 110         


Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
        115                 120                 125             


Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 
    130                 135                 140                 


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
145                 150                 155                 160 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                165                 170                 175     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            180                 185                 190         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        195                 200                 205             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    210                 215                 220                 


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
225                 230                 235                 240 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                245                 250                 255     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 
            260                 265                 270         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
        275                 280                 285             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    290                 295                 300                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 
305                 310                 315                 320 


Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                325                 330                 335     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 
            340                 345                 350         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 
        355                 360                 365             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    370                 375         


<210>  166
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  166

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ser Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Lys 
                325     


<210>  167
<211>  326
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  167

Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser 
1               5                   10                  15      


Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe 
            20                  25                  30          


Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly 
        35                  40                  45              


Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu 
    50                  55                  60                  


Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr 
65                  70                  75                  80  


Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg 
                85                  90                  95      


Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu 
            100                 105                 110         


Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Leu Gly Lys 
                325     


<210>  168
<211>  296
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  168

Asp Ala Ser Gly Asp Leu Tyr Thr Thr Ser Ser Gln Leu Thr Leu Pro 
1               5                   10                  15      


Ala Thr Gln Cys Leu Ala Gly Lys Ser Val Thr Cys His Val Lys His 
            20                  25                  30          


Tyr Thr Asn Pro Ser Gln Asp Val Thr Val Pro Cys Pro Val Pro Ser 
        35                  40                  45              


Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser 
    50                  55                  60                  


Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
65                  70                  75                  80  


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
                85                  90                  95      


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
            100                 105                 110         


Ala Val Gln Gly Pro Pro Asp Arg Asp Leu Cys Gly Cys Tyr Ser Val 
        115                 120                 125             


Ser Ser Val Leu Ser Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
    130                 135                 140                 


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
145                 150                 155                 160 


Thr Leu Ser Lys Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu 
                165                 170                 175     


Pro Pro Pro Ser Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr 
            180                 185                 190         


Cys Leu Ala Arg Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu 
        195                 200                 205             


Gln Gly Ser Gln Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser 
    210                 215                 220                 


Arg Gln Glu Pro Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile 
225                 230                 235                 240 


Leu Arg Val Ala Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys 
                245                 250                 255     


Met Val Gly His Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile 
            260                 265                 270         


Asp Arg Leu Ala Gly Lys Pro Thr His Val Asn Val Ser Val Val Met 
        275                 280                 285             


Ala Glu Val Asp Gly Thr Cys Tyr 
    290                 295     


<210>  169
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  169

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  170
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  170

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Leu Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  171
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  171

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  172
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  172

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Met Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Thr Val Val Cys Phe Val Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Asp Ile Ser Val Lys Trp Lys Ile Asp Gly Ser Glu Gln 
        35                  40                  45              


Arg Asp Gly Val Leu Asp Ser Val Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Ser Leu Thr Lys Val Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Leu Tyr Thr Cys Glu Val Val His Lys Thr Ser Ser Ser 
                85                  90                  95      


Pro Val Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  173
<211>  105
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence

<400>  173

Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105 


<210>  174
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  synthetic sequence


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa at position 2 is serine, threonine, alanine, or glycine.

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa at position 4 is serine, threonine, alanine, or glycine.

<400>  174

Cys Xaa Pro Xaa Arg 
1               5   


