                         SEQUENCE LISTING

<110>  Agency for Science, Technology and Research
       Agency for Science, Technology and Research
       Aslan Pharmaceuticals Pte. Ltd.
 
<120>  ANTIGEN SPECIFIC BINDING DOMAINS AND ANTIBODY MOLECULES

<130>  9869SG5952

<150>  SG10201909236R
<151>  2019-10-02

<160>  152   

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  1

Gln Ser Ile Gly Thr Ser 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  2

Tyr Ala Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  3

Gln Gln Ser Asp Ser Trp Pro Thr Thr 
1               5                   


<210>  4
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  4

Asp Ile Val Leu Thr Gln Thr Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
            20                  25      


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  5

Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
1               5                   10                  15      


Lys 
    


<210>  6
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  6

Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Ser Glu Asp Leu Ala 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  7

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
1               5                   10      


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  8

Asp Ile Val Leu Thr Gln Thr Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  9
gacattgtgc tgacccaaac tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaaatat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactcttc gcatcaacag tgtggagtct      240

gaggatcttg cagattatta ctgtcagcaa agtgatagct ggccaaccac gttcggaggg      300

gggaccaagc tggaaataaa acg                                              323


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  10

Gly Tyr Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  11

Ile Tyr Pro Gly Asn Val Asn Thr 
1               5               


<210>  12
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  12

Ala Arg Leu Gly Tyr Tyr Arg Tyr Gly Gly Ala Met Asp Tyr 
1               5                   10                  


<210>  13
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  13

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  14
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  14

Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  15
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  15

Lys Tyr Asn Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Val Tyr Phe Cys 
        35              


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  16

Trp Gly Gln Gly Thr Ala Val Thr Val Ser Ser 
1               5                   10      


<210>  17
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  17

Glu Val Gln Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Arg Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ala Val Thr Val Ser Ser 
        115                 120     


<210>  18
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  18
gaggtacagc tgcaggagtc aggacctgag ctggtgaagc ctgggacttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tgcattgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatac atttatcctg gaaatgttaa tactaaatac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aaggttgggc      300

tactataggt acgggggtgc tatggactac tggggtcaag gaaccgcagt caccgtctcc      360

tca                                                                    363


<210>  19
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  19

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  20
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  20

Tyr Thr Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  21

Gln Gln Tyr Asn Lys Leu Pro Trp Thr 
1               5                   


<210>  22
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  22

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser 
            20                  25      


<210>  23
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  23

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ile Val Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  24
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  24

Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  25

Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  26
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  26

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ile Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Lys Leu Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  27
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  27
gatattgtgc tgacccagac tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcagttgca gtgcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      120

gatggaattg ttaaactcct gatctattac acatcaagtt tacactcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat ttttctctca ccatcagcaa cctggaacct      240

gaagatattg ccacttacta ttgtcagcag tataataaac ttccgtggac attcggtgga      300

ggcaccaagc tggaaatcaa ac                                               322


<210>  28
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  28

Gly Tyr Ser Ile Thr Ser Gly Tyr Tyr 
1               5                   


<210>  29
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  29

Met Ser Tyr Asp Gly Ser Asn 
1               5           


<210>  30
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  30

Ser Arg Ala Leu Ala Tyr Tyr Gly Asn Phe Asp Tyr 
1               5                   10          


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  31

Leu Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Ser Val Thr 
            20                  25      


<210>  32
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  32

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
1               5                   10                  15      


Phe 
    


<210>  33
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  33

Asn Tyr Asn Pro Ser Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu Lys Leu Asn Ser Val Thr Ser Glu Asp 
            20                  25                  30          


Thr Ala Thr Tyr Tyr Cys 
        35              


<210>  34
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  34

Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
1               5                   10      


<210>  35
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  35

Leu Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser 
            20                  25                  30          


Gly Tyr Tyr Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Phe Met Ser Tyr Asp Gly Ser Asn Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu Lys Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ser Arg Ala Leu Ala Tyr Tyr Gly Asn Phe Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  36
cttgaggtaa agctggagga gtcaggacct ggcctcgtga aaccttctca gtctctgtct       60

ctcacctgct ctgtcactgg ctactccatc accagtggtt attactggaa ctggatccgg      120

caatttccag gaaacaaact ggaatggatg ggtttcatga gctacgacgg tagcaataac      180

tacaacccat ctctcaaaaa tcgaatctcc atcactcgtg acacatctaa gaaccagttt      240

ttcctgaaat tgaattctgt gacttctgag gacacagcta catattactg ttcaagagct      300

ctagcctact atggtaactt tgactactgg ggccaaggca ccactctcac agtctcctca      360


<210>  37
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  37

Gln Asn Val Asn Thr Asn 
1               5       


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  38

Ser Ala Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  39

Gln Gln Tyr Asn Thr Tyr Pro Leu Thr 
1               5                   


<210>  40
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  40

Asp Ile Val Leu Thr Gln Thr Pro Lys Val Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser 
            20                  25      


<210>  41
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  41

Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  42
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  42

Ser Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser Glu Asp Leu Ala 
            20                  25                  30          


Asp Tyr Phe Cys 
        35      


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  43

Phe Ala Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  44
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  44

Asp Ile Val Leu Thr Gln Thr Pro Lys Val Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asn Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Ser Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Phe Cys Gln Gln Tyr Asn Thr Tyr Pro Leu 
                85                  90                  95      


Thr Phe Ala Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  45
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  45
gacattgtgc tcacacaaac tccaaaagtc atgtccacat cagtaggaga cagggtcagc       60

gtcacctgca aggccagtca gaatgttaat actaatgtag cctggtatca acagaaacca      120

gggcaatctc ctaaagcact catttactcg gcatcctccc ggtacagtgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccatcagcaa tgtgcagtct      240

gaagacttgg ctgactattt ctgtcagcaa tataacacct atccgctcac gttcgctgct      300

gggaccaagc tggagctaaa ac                                               322


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  46

Gly Phe Thr Phe Ser Ser Phe Trp 
1               5               


<210>  47
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  47

Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  48

Ile Pro Pro Tyr Tyr Tyr Thr Val Asp Tyr 
1               5                   10  


<210>  49
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  49

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser 
            20                  25  


<210>  50
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  50

Met His Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Glu 
    


<210>  51
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  51

His Tyr Ala Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp 
1               5                   10                  15      


Ser Lys Ser Ser Val His Leu Gln Met Asn Asn Leu Arg Thr Glu Asp 
            20                  25                  30          


Thr Gly Ile Tyr Tyr Cys 
        35              


<210>  52
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  52

Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
1               5                   10      


<210>  53
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  53

Glu Val Lys Leu Gln Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Trp Met His Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Leu Lys Ser Asn Asn Tyr Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ser 
65                  70                  75                  80  


Val His Leu Gln Met Asn Asn Leu Arg Thr Glu Asp Thr Gly Ile Tyr 
                85                  90                  95      


Tyr Cys Ile Pro Pro Tyr Tyr Tyr Thr Val Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  54
gaagtgaagc tgcaggagtc tggaggaggc ttggtgcaac ctggaagatc cttgaaactc       60

tcctgtgttg cctctggatt cactttcagt agtttctgga tgcactgggt ccgccagtct      120

ccagagaagg gtcttgagtg ggttgctgaa attcgattga aatctaataa ttatgcaaca      180

cattatgcgg agtctgtgaa agggaggttc accatctcaa gagatgattc caaaagtagc      240

gtccacctgc aaatgaacaa cttaagaact gaagacactg gcatttatta ctgtatccca      300

ccctattact atactgtgga ctactggggt caaggaacct cagtcaccgt ctcctca         357


<210>  55
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  55
gacattgtga tgacacaatc tacagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtcg gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactcttc gcatcaacag tgtggagtct      240

gaagatcttg cagattatta ctgtcaacaa agtgatagct ggccaaccac gttcggaggg      300

gggaccaagc tggaaataaa acg                                              323


<210>  56
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  56

Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  57
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  57

Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  15      


Trp 
    


<210>  58
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  58

Gln Val Lys Leu Gln Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Trp Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Arg Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  59
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  59
caggtgaagc tgcaggagtc aggacctgag ctggtgaagc ctgggacttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tacattgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatgg atttatcctg gaaatgttaa tactaagtac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aaggttgggc      300

tactataggt acgggggtgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  60
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  60

Gln Asp Ile Ser Lys Tyr 
1               5       


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  61

Gln Gln Gly Asn Thr Leu Pro Arg Thr 
1               5                   


<210>  62
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  62

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser 
            20                  25      


<210>  63
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  63

Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  64
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  64

Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Ser Leu Thr Ile Thr Asn Leu Glu Gln Glu Asp Ile Ala 
            20                  25                  30          


Thr Tyr Phe Cys 
        35      


<210>  65
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  65

Asp Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Lys Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Thr Asn Leu Glu Gln 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln Gln Gly Asn Thr Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  66
<211>  322
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  66
gatattgtgc tcacccaatc tccatcctcc ctgtctgcct ctctgggaga cagagtcacc       60

atcacttgca gggcaagtca ggacattagc aaatacttaa actggtatca acagaaacca      120

gatggaactg ttaaactcct gatctactac acatcaacat tacattcagg agtcccatca      180

aggttcagtg gcagtgggtc tgggacagat ttttctctca ccattaccaa cctggagcaa      240

gaagatattg ccacttactt ttgccaacag ggcaatactc ttcctcggac gttcggtgga      300

ggcaccaagc tggaaatcaa ac                                               322


<210>  67
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  67

Gly Ser Ser Ile Thr Ser Asp Tyr Ala 
1               5                   


<210>  68
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  68

Ile Gly Tyr Ser Val Gly Thr 
1               5           


<210>  69
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  69

Ala Arg Arg Pro Leu Tyr Phe Tyr Tyr Ala Met Asp Phe 
1               5                   10              


<210>  70
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  70

Leu Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr 
            20                  25      


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  71

Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp Met Gly 
1               5                   10                  15      


Tyr 
    


<210>  72
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  72

Ser His Asn Pro Ser Leu Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr 
1               5                   10                  15      


Ser Lys Asn Gln Phe Phe Leu His Leu Asn Ser Val Thr Thr Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  73
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  73

Leu Glu Val Lys Leu Glu Glu Ser Gly Pro Gly Leu Leu Lys Pro Ser 
1               5                   10                  15      


Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Ser Ser Ile Thr Ser 
            20                  25                  30          


Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu 
        35                  40                  45              


Trp Met Gly Tyr Ile Gly Tyr Ser Val Gly Thr Ser His Asn Pro Ser 
    50                  55                  60                  


Leu Lys Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe 
65                  70                  75                  80  


Phe Leu His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Arg Pro Leu Tyr Phe Tyr Tyr Ala Met Asp Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  74
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  74
cttgaggtga agctggagga gtctggacct ggcctgttga aaccttctca gtctctgtcc       60

ctcacctgca ctgtcactgg ctcctcaatc accagtgatt atgcctggaa ctggatccgg      120

cagtttccag gaaacaaact ggagtggatg ggctacatag gttacagtgt tggcactagc      180

cacaacccat ctctcaaagg tcgaatctct atcactcgag acacatccaa gaaccagttc      240

ttcctgcact tgaattctgt gactactgag gacacagcca tatattactg tgcaagacgc      300

cctctctact tctactatgc tatggacttc tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  75
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  75

Lys Ser Val Ser Thr Ser Ala Tyr Asn Phe 
1               5                   10  


<210>  76
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  76

Leu Ala Ser 
1           


<210>  77
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  77

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  78
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  78

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser 
            20                  25      


<210>  79
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  79

Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  80
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  80

Asn Leu Glu Ser Gly Val Pro Ala Arg Leu Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Thr Asp Phe Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  81
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  81

Asp Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Ala Tyr Asn Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Leu Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  82
<211>  335
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  82
gacattgtgc tgacacagtc tcctgtttct ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acctctgcct ataattttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggctcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtac      300

acgttcggag gggggaccaa gctggaaata aaacg                                 335


<210>  83
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  83

Gly Tyr Thr Phe Thr Asp Tyr Asn 
1               5               


<210>  84
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  84

Ile Tyr Pro Tyr Asn Gly Asn Ser 
1               5               


<210>  85
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CRH3

<400>  85

Ala Ser Leu Tyr Tyr Leu Gly Tyr Phe Asp Val 
1               5                   10      


<210>  86
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  86

Glu Val Lys Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  87
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  87

Met His Trp Val Arg Gln Pro Pro Gly Gln Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Phe 
    


<210>  88
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  88

Gly Tyr Asn Pro Asn Phe Lys Thr Lys Ala Thr Leu Thr Met Asp Ile 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Met Glu Val Arg Asn Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Thr Tyr Phe Cys 
        35              


<210>  89
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  89

Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
1               5                   10      


<210>  90
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  90

Glu Val Lys Leu Glu Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Pro Pro Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Phe Ile Tyr Pro Tyr Asn Gly Asn Ser Gly Tyr Asn Pro Asn Phe 
    50                  55                  60                  


Lys Thr Lys Ala Thr Leu Thr Met Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Val Arg Asn Leu Thr Ser Glu Asp Ser Ala Thr Tyr Phe Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Leu Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  91
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  91
gaagtgaagc tggagcagtc tggacctgag ctggtgaaac ctggggcctc agtgaagata       60

tcctgcaagg cttctggata tacattcact gactacaaca tgcactgggt gaggcagccc      120

cctggacaga gccttgagtg gattggattt atttatcctt acaatggtaa ttctggctac      180

aatccgaact tcaagaccaa ggccacattg accatggaca tttcctccag cacagcctac      240

atggaggtcc gcaacctgac atctgaggat tctgcgacct atttctgtgc aagtctttat      300

tacctcggat acttcgatgt gtggggcgca gggaccacgg tcaccgtctc ctca            354


<210>  92
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  92

Asp Ile Val Leu Thr Gln Ser Thr Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser 
            20                  25      


<210>  93
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  93

Asp Ile Val Leu Thr Gln Ser Thr Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Ser Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gln Gln Ser Asp Ser Trp Pro Thr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  94
<211>  323
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  94
gacattgtgc tgacccagtc tacagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gagcattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaaatat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactcttc gcatcaacag tgtggagtct      240

gaggatcttg cagattatta ctgtcagcaa agtgatagct ggccaaccac gttcggaggg      300

gggaccaagc tggaaataaa acg                                              323


<210>  95
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  95

Glu Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  96
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  96

Glu Val Gln Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Pro Gly Thr 
1               5                   10                  15      


Ser Val Arg Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Tyr Pro Gly Asn Val Asn Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Arg Leu Gly Tyr Tyr Arg Tyr Gly Gly Ala Met Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     


<210>  97
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  97
gaggttcagc tggaggagtc tggacctgag ctggtgaagc ctgggacttc agtgaggata       60

tcctgcaagg cttctggcta caccttcaca agctactata tgcattgggt gaagcagagg      120

cctggacagg gacttgagtg gattggatac atttatcctg gaaatgttaa tactaaatac      180

aatgagaagt tcaagggcaa ggccacactg actgcagaca aatcctccag cacagcctac      240

atgcaactca gcagcctgac ctctgaggac tctgcggtct atttctgtgc aaggttgggc      300

tactataggt acgggggtgc tatggactac tggggtcaag gaacctcagt caccgtctcc      360

tca                                                                    363


<210>  98
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  98

Ser Ser Val Ser Tyr 
1               5   


<210>  99
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  99

Asp Thr Ser 
1           


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  100

Phe Gln Gly Asn Lys Tyr Pro Leu Thr 
1               5                   


<210>  101
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  101

Asp Ile Val Leu Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser 
            20                  25      


<210>  102
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  102

Ile His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile 
1               5                   10                  15      


Tyr 
    


<210>  103
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  103

Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Val Ala 
            20                  25                  30          


Thr Tyr Tyr Cys 
        35      


<210>  104
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  104

Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
1               5                   10  


<210>  105
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  105

Asp Ile Val Leu Thr Gln Thr Thr Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Ile 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Ser Thr Ser Pro Lys Leu Trp Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Gly Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Asn Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Val Ala Thr Tyr Tyr Cys Phe Gln Gly Asn Lys Tyr Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  106
<211>  319
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  106
gacattgtgc tgacacaaac tacagcaatc atgtctgcat ctccagggga aaaggtcacc       60

atgacctgca gtgccagctc aagtgtaagt tacatacact ggtaccagca gaagtcaagc      120

acctccccca aactctggat ttatgacaca tccaaactgg cttctggagt cccaggtcgc      180

ttcagtggca gtgggtctgg aaactcttac tctctcacga tcagcagcat ggaggctgaa      240

gatgttgcca cttactactg ttttcagggg aataagtacc cgctcacgtt cggtgctggg      300

accaagttgg agctgaaac                                                   319


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  107

Gly Phe Ser Leu Thr Ser Tyr Gly 
1               5               


<210>  108
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  108

Ile Trp Ala Gly Gly Thr Thr 
1               5           


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  109

Ala Ser Tyr Asp Tyr Asp Gly Tyr Phe Asp Val 
1               5                   10      


<210>  110
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  110

Gln Val Lys Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser 
            20                  25  


<210>  111
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  111

Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu Gly 
1               5                   10                  15      


Val 
    


<210>  112
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  112

Asn Tyr Asn Ser Ala Leu Met Ser Arg Leu Ser Ile Ser Lys Asp Asn 
1               5                   10                  15      


Ser Lys Ser Gln Val Phe Leu Lys Met Asn Ser Leu Gln Thr Asp Asp 
            20                  25                  30          


Thr Ala Met Tyr Tyr Cys 
        35              


<210>  113
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  113

Gln Val Lys Leu Gln Gln Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Ala Gly Gly Thr Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Ser Tyr Asp Tyr Asp Gly Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  114
<211>  351
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  114
caggtcaagc tgcagcagtc aggacctggc ctggtggcgc cctcacagag cctgtccatc       60

acttgcactg tctctggctt ttcattaacc agctatggtg tacactgggt tcgccagcct      120

ccaggaaagg gtctggagtg gctgggagtc atatgggctg gtggaaccac aaattataat      180

tcggctctca tgtctagact gagcatcagc aaagacaatt ccaagagcca agttttctta      240

aaaatgaaca gtctgcaaac tgatgacaca gccatgtact actgtgccag ttatgattac      300

gacgggtact tcgatgtctg gggcgcaggg accacggtca ccgtctcctc a               351


<210>  115
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  115

Gln Asp Ile Gly Ser Asn 
1               5       


<210>  116
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  116

Ala Thr Ser 
1           


<210>  117
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  117

Leu Gln Tyr Ile Ser Ser Pro Phe Thr 
1               5                   


<210>  118
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  118

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser 
            20                  25      


<210>  119
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  119

Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  120
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  120

Ser Leu Asp Pro Gly Val Pro Lys Arg Phe Ser Gly Ser Arg Ser Gly 
1               5                   10                  15      


Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser Glu Asp Phe Val 
            20                  25                  30          


Asp Tyr Tyr Cys 
        35      


<210>  121
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR4

<400>  121

Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
1               5                   10  


<210>  122
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  122

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Ser Leu Thr Cys Arg Ala Ser Gln Asp Ile Gly Ser Asn 
            20                  25                  30          


Leu Asn Trp Leu Gln Gln Glu Pro Asp Gly Thr Ile Lys Arg Leu Ile 
        35                  40                  45              


Tyr Ala Thr Ser Ser Leu Asp Pro Gly Val Pro Lys Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Ser Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Glu Asp Phe Val Asp Tyr Tyr Cys Leu Gln Tyr Ile Ser Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  123
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  123

Gly Ala Cys Ala Thr Thr Gly Thr Gly Cys Thr Cys Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Ala Cys Thr Cys Cys Ala Thr Cys Cys Thr Cys Cys Thr Thr 
            20                  25                  30          


Ala Thr Cys Thr Gly Cys Cys Thr Cys Thr Cys Thr Gly Gly Gly Ala 
        35                  40                  45              


Gly Ala Ala Ala Gly Ala Gly Thr Cys Ala Gly Thr Cys Thr Cys Ala 
    50                  55                  60                  


Cys Thr Thr Gly Thr Cys Gly Gly Gly Cys Ala Ala Gly Thr Cys Ala 
65                  70                  75                  80  


Gly Gly Ala Cys Ala Thr Thr Gly Gly Thr Ala Gly Thr Ala Ala Cys 
                85                  90                  95      


Thr Thr Ala Ala Ala Cys Thr Gly Gly Cys Thr Thr Cys Ala Gly Cys 
            100                 105                 110         


Ala Gly Gly Ala Ala Cys Cys Ala Gly Ala Thr Gly Gly Ala Ala Cys 
        115                 120                 125             


Thr Ala Thr Thr Ala Ala Ala Cys Gly Cys Cys Thr Gly Ala Thr Cys 
    130                 135                 140                 


Thr Ala Cys Gly Cys Cys Ala Cys Ala Thr Cys Cys Ala Gly Thr Thr 
145                 150                 155                 160 


Thr Ala Gly Ala Thr Cys Cys Ala Gly Gly Thr Gly Thr Cys Cys Cys 
                165                 170                 175     


Cys Ala Ala Ala Ala Gly Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys 
            180                 185                 190         


Ala Gly Thr Ala Gly Gly Thr Cys Thr Gly Gly Gly Thr Cys Ala Gly 
        195                 200                 205             


Ala Thr Thr Ala Thr Thr Cys Thr Cys Thr Cys Ala Cys Cys Ala Thr 
    210                 215                 220                 


Cys Ala Gly Cys Ala Gly Cys Cys Thr Thr Gly Ala Gly Thr Cys Thr 
225                 230                 235                 240 


Gly Ala Ala Gly Ala Thr Thr Thr Thr Gly Thr Ala Gly Ala Cys Thr 
                245                 250                 255     


Ala Thr Thr Ala Cys Thr Gly Thr Cys Thr Ala Cys Ala Ala Thr Ala 
            260                 265                 270         


Thr Ala Thr Thr Ala Gly Thr Thr Cys Thr Cys Cys Ala Thr Thr Cys 
        275                 280                 285             


Ala Cys Gly Thr Thr Cys Gly Gly Cys Thr Cys Gly Gly Gly Gly Ala 
    290                 295                 300                 


Cys Ala Ala Ala Gly Thr Thr Gly Gly Ala Ala Ala Thr Ala Ala Ala 
305                 310                 315                 320 


Ala Cys 
        


<210>  124
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  124

Gly Tyr Ser Phe Thr Gly Tyr Tyr 
1               5               


<210>  125
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  125

Ile Ser Cys Tyr Asn Gly Ala Thr 
1               5               


<210>  126
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  126

Ala Arg Gly Gly Thr Thr Ala Thr Pro Phe Asp Tyr 
1               5                   10          


<210>  127
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  127

Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser 
            20                  25  


<210>  128
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  128

Ile His Trp Val Lys Gln Ser His Gly Gln Ser Leu Glu Trp Ile Gly 
1               5                   10                  15      


Tyr 
    


<210>  129
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  129

Arg Tyr Asn Gln Lys Phe Lys Gly Lys Ala Ala Phe Thr Val Asp Thr 
1               5                   10                  15      


Ser Ser Ser Thr Ala Tyr Leu Gln Phe Asn Ser Leu Thr Ser Glu Asp 
            20                  25                  30          


Ser Ala Ile Tyr Tyr Cys 
        35              


<210>  130
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  130

Gln Val Lys Leu Glu Glu Ser Gly Pro Glu Leu Val Lys Thr Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Ser His Gly Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Ser Cys Tyr Asn Gly Ala Thr Arg Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ala Phe Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Phe Asn Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Thr Thr Ala Thr Pro Phe Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  131
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  131
caggttaagc tggaggagtc aggacctgag ctagtgaaga ctggggcttc agtgaagata       60

tcctgcaagg cttctggtta ctcattcact ggttactaca tacactgggt caagcagagc      120

catggacaga gccttgagtg gattggatat attagctgtt acaacggtgc tactagatat      180

aaccagaagt tcaagggcaa ggccgcattt actgtagaca catcctccag cacagcctac      240

ttacagttca acagcctgac atctgaagac tctgcgatct attactgtgc aagagggggt      300

actacggcta cgccctttga ctactggggc caaggcacca ctctcacagt ctcctca         357


<210>  132
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL1

<400>  132

Gln Asp Ile Asn Asn Tyr 
1               5       


<210>  133
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL2

<400>  133

His Ala Asp 
1           


<210>  134
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRL3

<400>  134

Leu Gln Tyr Asp Asp Phe Pro Pro Phe Thr 
1               5                   10  


<210>  135
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  135

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Met Tyr Ala Phe Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ile Cys Lys Ala Ser 
            20                  25      


<210>  136
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  136

Leu Asn Trp Val Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
1               5                   10                  15      


Tyr 
    


<210>  137
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  137

Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly 
1               5                   10                  15      


Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr Glu Asp Met Gly 
            20                  25                  30          


Ile Tyr Tyr Cys 
        35      


<210>  138
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain variable (amino acid)

<400>  138

Asp Ile Val Leu Thr Gln Thr Pro Ser Ser Met Tyr Ala Phe Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Ile Cys Lys Ala Ser Gln Asp Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Val Gln Gln Lys Pro Gly Lys Ala Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr His Ala Asp Arg Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Asp Phe Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  139
<211>  325
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Light chain variable (nucleotide sequence)

<400>  139
gacattgtgc tgacccaaac tccatcttcc atgtatgcat ttctaggaga gagagtcacc       60

atcatttgca aggcgagtca ggacatcaat aactatttaa actgggtcca gcagaaacca      120

gggaaagctc ctaagaccct gatctatcat gcagacagat tggcagatgg ggtcccatca      180

aggttcagtg gcagtgggtc tgggcaagat tattctctca ccatcagcag cctggaatat      240

gaagatatgg gaatttatta ttgtctacag tatgatgact ttcctccatt cacgttcggc      300

tcggggacaa agttggaaat aaaac                                            325


<210>  140
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH1

<400>  140

Gly Phe Thr Phe Ser Ser Phe Gly 
1               5               


<210>  141
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH2

<400>  141

Ile Ser Gly Gly Ser Gly Thr Phe 
1               5               


<210>  142
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CDRH3

<400>  142

Ala Arg Ser Thr Thr Val Leu Asp Tyr 
1               5                   


<210>  143
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR1

<400>  143

Glu Val Lys Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser 
            20                  25  


<210>  144
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR2

<400>  144

Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  15      


Tyr 
    


<210>  145
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FR3

<400>  145

Tyr Tyr Ala Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
1               5                   10                  15      


Pro Lys Asn Thr Leu Phe Leu Gln Met Thr Ser Leu Arg Ser Glu Asp 
            20                  25                  30          


Thr Ala Ile Tyr Tyr Cys 
        35              


<210>  146
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (amino acid)

<400>  146

Glu Val Lys Leu Glu Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile Ser Gly Gly Ser Gly Thr Phe Tyr Tyr Ala Asp Thr Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Thr Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Thr Thr Val Leu Asp Tyr Trp Gly Gln Gly Thr Thr Leu 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  147
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Heavy chain variable (nucleotide sequence)

<400>  147
gaagttaagc tggagcagtc tgggggaggc ttagtgcagc ctggagggtc ccggaaactc       60

tcctgtgcag cctctggatt cactttcagt agctttggga tgcactgggt tcgtcaggct      120

ccagagaagg ggctggagtg ggtcgcatat attagtggtg gcagtggtac cttctactat      180

gcagacacag tgaagggccg attcaccatc tccagagaca atcccaagaa caccctattc      240

ctgcaaatga ccagtctaag gtctgaggac acggccattt attactgtgc aagatcgact      300

acggttcttg actattgggg ccaaggcacc actctcacag tctcctca                   348


<210>  148
<211>  1400
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length RON protein amino acid sequence

<400>  148

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Ala Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Arg Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Gln Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile 
                885                 890                 895     


Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp 
            900                 905                 910         


Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly 
        915                 920                 925             


Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg 
    930                 935                 940                 


Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly 
945                 950                 955                 960 


Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu 
                965                 970                 975     


Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu 
        995                 1000                 1005             


Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu 
    1010                 1015                 1020             


Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala 
    1025                 1030                 1035             


Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg 
    1040                 1045                 1050             


Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala 
    1055                 1060                 1065             


Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His 
    1070                 1075                 1080             


Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His 
    1085                 1090                 1095             


Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile 
    1100                 1105                 1110             


Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val 
    1130                 1135                 1140             


Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His 
    1145                 1150                 1155             


Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile 
    1160                 1165                 1170             


Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe 
    1175                 1180                 1185             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys 
    1190                 1195                 1200             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1205                 1210                 1215             


Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1220                 1225                 1230             


Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg 
    1235                 1240                 1245             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1265                 1270                 1275             


Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro 
    1280                 1285                 1290             


Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln 
    1295                 1300                 1305             


Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys 
    1310                 1315                 1320             


Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val 
    1325                 1330                 1335             


Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr 
    1340                 1345                 1350             


Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser 
    1355                 1360                 1365             


His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met 
    1370                 1375                 1380             


Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Ser Glu  Pro Pro Arg 
    1385                 1390                 1395             


Pro Thr  
    1400 


<210>  149
<211>  933
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Full length RON extracellular domain (ECD) amino acid sequence

<400>  149

Glu Asp Trp Gln Cys Pro Arg Thr Pro Tyr Ala Ala Ser Arg Asp Phe 
1               5                   10                  15      


Asp Val Lys Tyr Val Val Pro Ser Phe Ser Ala Gly Gly Leu Val Gln 
            20                  25                  30          


Ala Met Val Thr Tyr Glu Gly Asp Arg Asn Glu Ser Ala Val Phe Val 
        35                  40                  45              


Ala Ile Arg Asn Arg Leu His Val Leu Gly Pro Asp Leu Lys Ser Val 
    50                  55                  60                  


Gln Ser Leu Ala Thr Gly Pro Ala Gly Asp Pro Gly Cys Gln Thr Cys 
65                  70                  75                  80  


Ala Ala Cys Gly Pro Gly Pro His Gly Pro Pro Gly Asp Thr Asp Thr 
                85                  90                  95      


Lys Val Leu Val Leu Asp Pro Ala Leu Pro Ala Leu Val Ser Cys Gly 
            100                 105                 110         


Ser Ser Leu Gln Gly Arg Cys Phe Leu His Asp Leu Glu Pro Gln Gly 
        115                 120                 125             


Thr Ala Val His Leu Ala Ala Pro Ala Cys Leu Phe Ser Ala His His 
    130                 135                 140                 


Asn Arg Pro Asp Asp Cys Pro Asp Cys Val Ala Ser Pro Leu Gly Thr 
145                 150                 155                 160 


Arg Val Thr Val Val Glu Gln Gly Gln Ala Ser Tyr Phe Tyr Val Ala 
                165                 170                 175     


Ser Ser Leu Asp Ala Ala Val Ala Ala Ser Phe Ser Pro Arg Ser Val 
            180                 185                 190         


Ser Ile Arg Arg Leu Lys Ala Asp Ala Ser Gly Phe Ala Pro Gly Phe 
        195                 200                 205             


Val Ala Leu Ser Val Leu Pro Lys His Leu Val Ser Tyr Ser Ile Glu 
    210                 215                 220                 


Tyr Val His Ser Phe His Thr Gly Ala Phe Val Tyr Phe Leu Thr Val 
225                 230                 235                 240 


Gln Pro Ala Ser Val Thr Asp Asp Pro Ser Ala Leu His Thr Arg Leu 
                245                 250                 255     


Ala Arg Leu Ser Ala Thr Glu Pro Glu Leu Gly Asp Tyr Arg Glu Leu 
            260                 265                 270         


Val Leu Asp Cys Arg Phe Ala Pro Lys Arg Arg Arg Arg Gly Ala Pro 
        275                 280                 285             


Glu Gly Gly Gln Pro Tyr Pro Val Leu Arg Val Ala His Ser Ala Pro 
    290                 295                 300                 


Val Gly Ala Gln Leu Ala Thr Glu Leu Ser Ile Ala Glu Gly Gln Glu 
305                 310                 315                 320 


Val Leu Phe Gly Val Phe Val Thr Gly Lys Asp Gly Gly Pro Gly Val 
                325                 330                 335     


Gly Pro Asn Ser Val Val Cys Ala Phe Pro Ile Asp Leu Leu Asp Thr 
            340                 345                 350         


Leu Ile Asp Glu Gly Val Glu Arg Cys Cys Glu Ser Pro Val His Pro 
        355                 360                 365             


Gly Leu Arg Arg Gly Leu Asp Phe Phe Gln Ser Pro Ser Phe Cys Pro 
    370                 375                 380                 


Asn Pro Pro Gly Leu Glu Ala Leu Ser Pro Asn Thr Ser Cys Arg His 
385                 390                 395                 400 


Phe Pro Leu Leu Val Ser Ser Ser Phe Ser Arg Val Asp Leu Phe Asn 
                405                 410                 415     


Gly Leu Leu Gly Pro Val Gln Val Thr Ala Leu Tyr Val Thr Arg Leu 
            420                 425                 430         


Asp Asn Val Thr Val Ala His Met Gly Thr Met Asp Gly Arg Ile Leu 
        435                 440                 445             


Gln Val Glu Leu Val Arg Ser Leu Asn Tyr Leu Leu Tyr Val Ser Asn 
    450                 455                 460                 


Phe Ser Leu Gly Asp Ser Gly Gln Pro Val Gln Arg Asp Val Ser Arg 
465                 470                 475                 480 


Leu Gly Asp His Leu Leu Phe Ala Ser Gly Asp Gln Val Phe Gln Val 
                485                 490                 495     


Pro Ile Gln Gly Pro Gly Cys Arg His Phe Leu Thr Cys Gly Arg Cys 
            500                 505                 510         


Leu Arg Ala Trp His Phe Met Gly Cys Gly Trp Cys Gly Asn Met Cys 
        515                 520                 525             


Gly Gln Gln Lys Glu Cys Pro Gly Ser Trp Gln Gln Asp His Cys Pro 
    530                 535                 540                 


Pro Lys Leu Thr Glu Phe His Pro His Ser Gly Pro Leu Arg Gly Ser 
545                 550                 555                 560 


Thr Arg Leu Thr Leu Cys Gly Ser Asn Phe Tyr Leu His Pro Ser Gly 
                565                 570                 575     


Leu Val Pro Glu Gly Thr His Gln Val Thr Val Gly Gln Ser Pro Cys 
            580                 585                 590         


Arg Pro Leu Pro Lys Asp Ser Ser Lys Leu Arg Pro Val Pro Arg Lys 
        595                 600                 605             


Asp Phe Val Glu Glu Phe Glu Cys Glu Leu Glu Pro Leu Gly Thr Gln 
    610                 615                 620                 


Ala Val Gly Pro Thr Asn Val Ser Leu Thr Val Thr Asn Met Pro Pro 
625                 630                 635                 640 


Gly Lys His Phe Arg Val Asp Gly Thr Ser Val Leu Arg Gly Phe Ser 
                645                 650                 655     


Phe Met Glu Pro Val Leu Ile Ala Val Gln Pro Leu Phe Gly Pro Arg 
            660                 665                 670         


Ala Gly Gly Thr Cys Leu Thr Leu Glu Gly Gln Ser Leu Ser Val Gly 
        675                 680                 685             


Thr Ser Arg Ala Val Leu Val Asn Gly Thr Glu Cys Leu Leu Ala Arg 
    690                 695                 700                 


Val Ser Glu Gly Gln Leu Leu Cys Ala Thr Pro Pro Gly Ala Thr Val 
705                 710                 715                 720 


Ala Ser Val Pro Leu Ser Leu Gln Val Gly Gly Ala Gln Val Pro Gly 
                725                 730                 735     


Ser Trp Thr Phe Gln Tyr Arg Glu Asp Pro Val Val Leu Ser Ile Ser 
            740                 745                 750         


Pro Asn Cys Gly Tyr Ile Asn Ser His Ile Thr Ile Cys Gly Gln His 
        755                 760                 765             


Leu Thr Ser Ala Trp His Leu Val Leu Ser Phe His Asp Gly Leu Arg 
    770                 775                 780                 


Ala Val Glu Ser Arg Cys Glu Arg Gln Leu Pro Glu Gln Gln Leu Cys 
785                 790                 795                 800 


Arg Leu Pro Glu Tyr Val Val Arg Asp Pro Gln Gly Trp Val Ala Gly 
                805                 810                 815     


Asn Leu Ser Ala Arg Gly Asp Gly Ala Ala Gly Phe Thr Leu Pro Gly 
            820                 825                 830         


Phe Arg Phe Leu Pro Pro Pro His Pro Pro Ser Ala Asn Leu Val Pro 
        835                 840                 845             


Leu Lys Pro Glu Glu His Ala Ile Lys Phe Glu Tyr Ile Gly Leu Gly 
    850                 855                 860                 


Ala Val Ala Asp Cys Val Gly Ile Asn Val Thr Val Gly Gly Glu Ser 
865                 870                 875                 880 


Cys Gln His Glu Phe Arg Gly Asp Met Val Val Cys Pro Leu Pro Pro 
                885                 890                 895     


Ser Leu Gln Leu Gly Gln Asp Gly Ala Pro Leu Gln Val Cys Val Asp 
            900                 905                 910         


Gly Glu Cys His Ile Leu Gly Arg Val Val Arg Pro Gly Pro Asp Gly 
        915                 920                 925             


Val Pro Gln Ser Thr 
    930             


<210>  150
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RON KO sequencing primer (Forward)

<400>  150
ggtccgctat cttggggc                                                     18


<210>  151
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RON KO sequencing primer (Reverse)

<400>  151
ctgggcacca cgtacttcac                                                   20


<210>  152
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RON KO gRNA spacer

<400>  152
ggcgggagga gctccatcg                                                    19


