                         SEQUENCE LISTING

<110>  Case Western Reserve Univeristy
 
<120>  TARGETING B CELL ACTIVATING FACTOR RECEPTOR (BAFF-R) USING 
       LIGAND-BASED CHIMERIC ANTIGEN RECEPTOR (CAR)-T CELLS

<130>  CASEU-61047US3

<160>  23    

<170>  PatentIn version 3.5

<210>  1
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        275                 280                 285 


<210>  2
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  2

Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala 
1               5                   10                  15      


Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys 
            20                  25                  30          


Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser 
        35                  40                  45              


Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
    50                  55                  60                  


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
65                  70                  75                  80  


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
                85                  90                  95      


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
            100                 105                 110         


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
        115                 120                 125             


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
    130                 135                 140                 


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
145                 150                 155                 160 


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
                165                 170                 175     


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
            180                 185                 190         


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
        195                 200                 


<210>  3
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu 
145                 150         


<210>  4
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  5
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Lys Asp Pro Lys 
            20  


<210>  6
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr Cys 
            20                  


<210>  7
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu 
1               5                   10                  15      


Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val 
            20                  25          


<210>  8
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  8

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  9
<211>  41
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  10
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  10

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  11
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  11

Arg Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly 
1               5                   10                  15      


Ser Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr 
            20                  25                  30          


Leu Ala Lys Ile 
        35      


<210>  12
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Gly Gly Gly Ser Asp Pro 
1               5           


<210>  13
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly 
            20  


<210>  14
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: CD8 alpha leader sequence

<400>  14

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro 
            20      


<210>  15
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF - CD8  hinge - CD8  transmembrane - 
       41BB intracellular - CD3-zeta

<400>  15

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr 
        275                 280                 285             


Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro 
    290                 295                 300                 


Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val 
305                 310                 315                 320 


His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro 
                325                 330                 335     


Leu Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu 
            340                 345                 350         


Tyr Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
        355                 360                 365             


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
    370                 375                 380                 


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
385                 390                 395                 400 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
                405                 410                 415     


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
            420                 425                 430         


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys 
        435                 440                 445             


Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala 
    450                 455                 460                 


Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys 
465                 470                 475                 480 


Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr 
                485                 490                 495     


Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            500                 505             


<210>  16
<211>  427
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF partial - CD8  hinge - CD8  
       transmembrane - 41BB intracellular - CD3-zeta

<400>  16

Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala 
1               5                   10                  15      


Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys 
            20                  25                  30          


Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser 
        35                  40                  45              


Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
    50                  55                  60                  


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
65                  70                  75                  80  


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
                85                  90                  95      


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
            100                 105                 110         


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
        115                 120                 125             


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
    130                 135                 140                 


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
145                 150                 155                 160 


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
                165                 170                 175     


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
            180                 185                 190         


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr Pro 
        195                 200                 205             


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
    210                 215                 220                 


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
225                 230                 235                 240 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
                245                 250                 255     


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
            260                 265                 270         


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
        275                 280                 285             


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
    290                 295                 300                 


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
305                 310                 315                 320 


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
                325                 330                 335     


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
            340                 345                 350         


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
        355                 360                 365             


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
    370                 375                 380                 


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
385                 390                 395                 400 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
                405                 410                 415     


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            420                 425         


<210>  17
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF partial - CD8  hinge - CD8  
       transmembrane - 41BB intracellular - CD3-zeta

<400>  17

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu Thr Thr Thr Pro Ala Pro Arg Pro 
145                 150                 155                 160 


Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro 
                165                 170                 175     


Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu 
            180                 185                 190         


Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys 
        195                 200                 205             


Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr Cys Lys Arg Gly 
    210                 215                 220                 


Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro Val 
225                 230                 235                 240 


Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu 
                245                 250                 255     


Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala Asp 
            260                 265                 270         


Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
        275                 280                 285             


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
    290                 295                 300                 


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
305                 310                 315                 320 


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
                325                 330                 335     


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
            340                 345                 350         


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
        355                 360                 365             


Met Gln Ala Leu Pro Pro Arg 
    370                 375 


<210>  18
<211>  528
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF - IgG1 hinge - CD28 transmb - CD28 and 
       OX signalling - CD3 zeta signalling

<400>  18

Met Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr Ser Cys Leu 
1               5                   10                  15      


Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser Ile Leu Pro 
            20                  25                  30          


Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly Lys Leu Leu 
        35                  40                  45              


Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu Thr Val Val 
    50                  55                  60                  


Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala Ser Leu Arg 
65                  70                  75                  80  


Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly 
                85                  90                  95      


Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu 
            100                 105                 110         


Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn 
        115                 120                 125             


Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
    130                 135                 140                 


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
145                 150                 155                 160 


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
                165                 170                 175     


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
            180                 185                 190         


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
        195                 200                 205             


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
    210                 215                 220                 


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
225                 230                 235                 240 


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
                245                 250                 255     


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
            260                 265                 270         


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Ser Gly Gly 
        275                 280                 285             


Gly Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys 
    290                 295                 300                 


Pro Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly 
305                 310                 315                 320 


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
                325                 330                 335     


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
            340                 345                 350         


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
        355                 360                 365             


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg 
    370                 375                 380                 


Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
385                 390                 395                 400 


Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
                405                 410                 415     


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
            420                 425                 430         


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
        435                 440                 445             


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
    450                 455                 460                 


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
465                 470                 475                 480 


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
                485                 490                 495     


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
            500                 505                 510         


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        515                 520                 525             


<210>  19
<211>  447
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF parital - IgG1 hinge - CD28 transmb - 
       CD28 and OX signalling - CD3 zeta signalling

<400>  19

Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala Gly Ala Gly Ala 
1               5                   10                  15      


Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr Ala Gly Leu Lys 
            20                  25                  30          


Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser Ser Gln Asn Ser 
        35                  40                  45              


Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
    50                  55                  60                  


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
65                  70                  75                  80  


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
                85                  90                  95      


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
            100                 105                 110         


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
        115                 120                 125             


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
    130                 135                 140                 


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
145                 150                 155                 160 


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
                165                 170                 175     


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
            180                 185                 190         


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Ser Gly Gly Gly 
        195                 200                 205             


Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
    210                 215                 220                 


Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
225                 230                 235                 240 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                245                 250                 255     


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
            260                 265                 270         


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
        275                 280                 285             


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu 
    290                 295                 300                 


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
305                 310                 315                 320 


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
                325                 330                 335     


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
            340                 345                 350         


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
        355                 360                 365             


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
    370                 375                 380                 


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
385                 390                 395                 400 


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
                405                 410                 415     


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
            420                 425                 430         


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
        435                 440                 445         


<210>  20
<211>  395
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: BAFF parital - IgG1 hinge - CD28 transmb - 
       CD28 and OX signalling - CD3 zeta signalling

<400>  20

Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp Cys Leu Gln Leu 
1               5                   10                  15      


Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly Ser Tyr Thr Phe 
            20                  25                  30          


Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala Leu Glu Glu Lys 
        35                  40                  45              


Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe Phe Ile Tyr Gly 
    50                  55                  60                  


Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly His Leu Ile Gln 
65                  70                  75                  80  


Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser Leu Val Thr Leu 
                85                  90                  95      


Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro Asn Asn Ser Cys 
            100                 105                 110         


Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp Glu Leu Gln Leu 
        115                 120                 125             


Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp Gly Asp Val Thr 
    130                 135                 140                 


Phe Phe Gly Ala Leu Lys Leu Leu Ser Gly Gly Gly Ser Asp Pro Ala 
145                 150                 155                 160 


Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Lys 
                165                 170                 175     


Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
            180                 185                 190         


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Arg Ser 
        195                 200                 205             


Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr Pro Arg 
    210                 215                 220                 


Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro Pro Arg 
225                 230                 235                 240 


Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu Pro Pro Asp Ala 
                245                 250                 255     


His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro Ile Gln Glu Glu 
            260                 265                 270         


Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg Val Lys Phe Ser 
        275                 280                 285             


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
    290                 295                 300                 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
305                 310                 315                 320 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
                325                 330                 335     


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
            340                 345                 350         


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
        355                 360                 365             


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
    370                 375                 380                 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
385                 390                 395 


<210>  21
<211>  547
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: Signal peptide - BAFF - linker - IgG1 hinge 
       - CD28 transmb - CD28 and OX40 signalling - CD3 zeta signalling

<400>  21

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Asp Asp Ser Thr Glu Arg Glu Gln Ser Arg Leu Thr 
            20                  25                  30          


Ser Cys Leu Lys Lys Arg Glu Glu Met Lys Leu Lys Glu Cys Val Ser 
        35                  40                  45              


Ile Leu Pro Arg Lys Glu Ser Pro Ser Val Arg Ser Ser Lys Asp Gly 
    50                  55                  60                  


Lys Leu Leu Ala Ala Thr Leu Leu Leu Ala Leu Leu Ser Cys Cys Leu 
65                  70                  75                  80  


Thr Val Val Ser Phe Tyr Gln Val Ala Ala Leu Gln Gly Asp Leu Ala 
                85                  90                  95      


Ser Leu Arg Ala Glu Leu Gln Gly His His Ala Glu Lys Leu Pro Ala 
            100                 105                 110         


Gly Ala Gly Ala Pro Lys Ala Gly Leu Glu Glu Ala Pro Ala Val Thr 
        115                 120                 125             


Ala Gly Leu Lys Ile Phe Glu Pro Pro Ala Pro Gly Glu Gly Asn Ser 
    130                 135                 140                 


Ser Gln Asn Ser Arg Asn Lys Arg Ala Val Gln Gly Pro Glu Glu Thr 
145                 150                 155                 160 


Val Thr Gln Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr 
                165                 170                 175     


Ile Gln Lys Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys 
            180                 185                 190         


Arg Gly Ser Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu 
        195                 200                 205             


Thr Gly Tyr Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr 
    210                 215                 220                 


Tyr Ala Met Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly 
225                 230                 235                 240 


Asp Glu Leu Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro 
                245                 250                 255     


Glu Thr Leu Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu 
            260                 265                 270         


Glu Glu Gly Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln 
        275                 280                 285             


Ile Ser Leu Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu 
    290                 295                 300                 


Ser Gly Gly Gly Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr 
305                 310                 315                 320 


His Thr Cys Pro Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val 
                325                 330                 335     


Val Val Gly Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala 
            340                 345                 350         


Phe Ile Ile Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser 
        355                 360                 365             


Asp Tyr Met Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His 
    370                 375                 380                 


Tyr Gln Pro Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg 
385                 390                 395                 400 


Asp Gln Arg Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser 
                405                 410                 415     


Phe Arg Thr Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu 
            420                 425                 430         


Ala Lys Ile Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr 
        435                 440                 445             


Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg 
    450                 455                 460                 


Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met 
465                 470                 475                 480 


Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu 
                485                 490                 495     


Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys 
            500                 505                 510         


Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu 
        515                 520                 525             


Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu 
    530                 535                 540                 


Pro Pro Arg 
545         


<210>  22
<211>  415
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: Signal peptide - BAFF partial - linker - 
       IgG1 hinge - CD28 transmb - CD28 and OX40 signalling - CD3 zeta 
       signalling

<400>  22

Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val Pro 
1               5                   10                  15      


Gly Ser Thr Gly Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln Asp 
            20                  25                  30          


Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys Gly 
        35                  40                  45              


Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser Ala 
    50                  55                  60                  


Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr Phe 
65                  70                  75                  80  


Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met Gly 
                85                  90                  95      


His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu Ser 
            100                 105                 110         


Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu Pro 
        115                 120                 125             


Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly Asp 
    130                 135                 140                 


Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu Asp 
145                 150                 155                 160 


Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Ser Gly Gly Gly 
                165                 170                 175     


Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys Pro 
            180                 185                 190         


Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly Gly 
        195                 200                 205             


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    210                 215                 220                 


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
225                 230                 235                 240 


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                245                 250                 255     


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg Leu 
            260                 265                 270         


Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr Pro 
        275                 280                 285             


Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile Arg 
    290                 295                 300                 


Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln 
305                 310                 315                 320 


Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp 
                325                 330                 335     


Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro 
            340                 345                 350         


Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp 
        355                 360                 365             


Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg 
    370                 375                 380                 


Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr 
385                 390                 395                 400 


Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410                 415 


<210>  23
<211>  416
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct: alternaitive signal peptide - BAFF partial -
       linker - IgG1 hinge - CD28 transmb - CD28 and OX40 signalling - 
       CD3 zeta signalling

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Ala Val Gln Gly Pro Glu Glu Thr Val Thr Gln 
            20                  25                  30          


Asp Cys Leu Gln Leu Ile Ala Asp Ser Glu Thr Pro Thr Ile Gln Lys 
        35                  40                  45              


Gly Ser Tyr Thr Phe Val Pro Trp Leu Leu Ser Phe Lys Arg Gly Ser 
    50                  55                  60                  


Ala Leu Glu Glu Lys Glu Asn Lys Ile Leu Val Lys Glu Thr Gly Tyr 
65                  70                  75                  80  


Phe Phe Ile Tyr Gly Gln Val Leu Tyr Thr Asp Lys Thr Tyr Ala Met 
                85                  90                  95      


Gly His Leu Ile Gln Arg Lys Lys Val His Val Phe Gly Asp Glu Leu 
            100                 105                 110         


Ser Leu Val Thr Leu Phe Arg Cys Ile Gln Asn Met Pro Glu Thr Leu 
        115                 120                 125             


Pro Asn Asn Ser Cys Tyr Ser Ala Gly Ile Ala Lys Leu Glu Glu Gly 
    130                 135                 140                 


Asp Glu Leu Gln Leu Ala Ile Pro Arg Glu Asn Ala Gln Ile Ser Leu 
145                 150                 155                 160 


Asp Gly Asp Val Thr Phe Phe Gly Ala Leu Lys Leu Leu Ser Gly Gly 
                165                 170                 175     


Gly Ser Asp Pro Ala Glu Pro Lys Ser Pro Asp Lys Thr His Thr Cys 
            180                 185                 190         


Pro Pro Cys Pro Lys Asp Pro Lys Phe Trp Val Leu Val Val Val Gly 
        195                 200                 205             


Gly Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile 
    210                 215                 220                 


Phe Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met 
225                 230                 235                 240 


Asn Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro 
                245                 250                 255     


Tyr Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Asp Gln Arg 
            260                 265                 270         


Leu Pro Pro Asp Ala His Lys Pro Pro Gly Gly Gly Ser Phe Arg Thr 
        275                 280                 285             


Pro Ile Gln Glu Glu Gln Ala Asp Ala His Ser Thr Leu Ala Lys Ile 
    290                 295                 300                 


Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
305                 310                 315                 320 


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
                325                 330                 335     


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
            340                 345                 350         


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
        355                 360                 365             


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
    370                 375                 380                 


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
385                 390                 395                 400 


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                405                 410                 415     


