                         SEQUENCE LISTING

<110>  Cancer Research Technology Limited
 
<120>  Targeting expression of KRAS and related methods

<130>  P36564WO1

<150>  GB 1914354.4
<151>  2019-10-04

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  1
hhbkhsdbbw rvdbkt                                                       16


<210>  2
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  2
mwyybkrrvm bgrdrr                                                       16


<210>  3
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  3
aacgagtgca aagtgt                                                       16


<210>  4
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  4
tctgtggtgt gctctt                                                       16


<210>  5
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  5
ctgtccactt ggagtt                                                       16


<210>  6
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  6
attctgggac ggagag                                                       16


<210>  7
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  7
cattctggga cggaga                                                       16


<210>  8
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  antisense oligonucleotide

<400>  8
atctgtaaca tggtga                                                       16


<210>  9
<211>  912
<212>  DNA
<213>  Homo sapiens

<220>
<223>  ENSG00000228709

<400>  9
tgctggatgc tgagaggaac gcatcagtgg aagaaaacaa gcggctggac gtggagagga       60

cgtcaaggga gcatgccggc ggaagagcac accacagacg ccggcaggcc accgagcggc      120

aggaccaggc ggagtttggc cggggcagtc ggaggagagc taggccacta agcagctcaa      180

ctccaggaga taaaccatct cccttgtggc tcctccgtcg gctgagagct gcttccactc      240

aataacactt tgcactcgtt ctccaagccc ccgtgtgatc cgattcttct ggtacaccca      300

ggcaagaacc caggatacag aaaggcctcg gtcctttcca caagtacctc tacttgaggt      360

actcattgac ctggttaaca caagctgcct acagacgcca aaactaaggg caccctggaa      420

cacaggcttc agctgtaaac attcacccct gggcactgcc gtggggtggg agcctgcctg      480

agtgtatgct cccctagagg tttgagctgc ggggcactga agaagtgagc cacactccca      540

tcgcacactg cgagggggac aaaggaactt ttcctctttt aactggggcc tcatctggaa      600

tctcggaagg tgaatgtctg ccttcgaaaa ccctaccacc tgtctttctt gtggaaccat      660

caaactccaa gtggacaggc aactggagcc tcagataatg actccccttt gctaggaacc      720

cttagacaga cctctgggag gaatttgact gccgttttct caaaaacaac gccccctgtc      780

agcgggaagc agctaagaca ggtcatcgtc catattctaa tagcagttag atgtacgttt      840

tcagagaggg gaaatgatac aggagtgcgg ggaagggaag agtgtcatct ctttaaatga      900

tacagaaggg ag                                                          912


<210>  10
<211>  533
<212>  DNA
<213>  Homo sapiens

<220>
<223>  ENSG00000258667

<400>  10
tcatgtagcg ccagccacac caggaacaga agggtgccgg gtaccttccg catgcttggt       60

attctccccg cggggctctg accgctgccg ctctcaggca cctgtctttc ctctccgtcc      120

cagaatggag ccaagacaag ggaataaacg aaattcaata gtacacggag atcgggtgtc      180

tgggcagcgt cttggaaaaa ctatccacta cagtacaggt caagtgaagt tcttctgctg      240

atatgttctg ctactgcata agagacggaa tctatgttgc ctcgactggt cctgaactcc      300

tgggctaaag cgatccttct gccttggcct cccaaagtgc gaggattata ggtgtgagcc      360

acccaacctg gcctttgcca gtatttttaa atccaaacac ctatgcatgg tgcttactaa      420

taacacagtg gtattctaaa catttttcac ctattattta atctttatta ttatcaccat      480

gttacagata aggaccctgg ctaaatagct tacccaacat tactccgtta ata             533


<210>  11
<211>  1990
<212>  DNA
<213>  Homo sapiens

<220>
<223>  ENSG00000261280

<400>  11
atcattatct gcagagaatt tcagtatatc ttcgagttcc ttgttagtat ttatgctctc       60

ttatttgtgt tgggatagaa agattaagga aaggagagat gagaaggtgg ctcaacagtt      120

gagacagttt tattgggagt aaacctgaga agggcttcca gcggcagggt caggtgcaaa      180

cttctcttac agcctgaggc ttttttaaag ggcccagtgg agaagtgtgc tttgaaacaa      240

aattctgtta gggaggggtt ggggaagtcc tggctgttct gttacagtta gggccgttat      300

tctctgttga agttatgggc ggggctgaca ttttcagttt tggccaggtg gccaaataga      360

aacttaaagc ttaggatggt ggagtgttat aaagatggcg gtgctcttgt cctgtcaatg      420

tgttcctcaa taaagtcttc aagcatgtca tagattgttt tccccaccaa cctcccttgc      480

agcatttgag atattcctga tacttcatca atagtggaga agctcctgaa atcattgact      540

tcctcactcc ataatggttt ccaacaccca atgaagtagt aggaggaaaa catgggtttc      600

ttctcctgga agcctccaga agaaggtatt tcaatatggg gagagtggtc agctgtgtca      660

caggtcactg agaatttgaa taagacaagg aaaaagggtt gactgtagat tttggcaagt      720

atttggtcac tgggggcctt gataagagct gtttcattga agtattcatg agaataactt      780

gtagtgaaat atatctcaaa tagacctcca cgatgttgcc tagagggcag tgttaccctt      840

tgaactacca acattaacca ctggaactgc tcatctggaa gcctcttaca gtgctggtac      900

aaactagaat acacaaagga agggatcatt ttatacgtgt tactgtgcta cttgctctat      960

ctacttagtg ttccatacat gtaattacct attccatcct atcccaaagt actgaaaatc     1020

tccattctac tttctctgtc tgtgaatttg actattcata gagagagaga tatgtggaag     1080

tatgcatgtg tccttccatg tctggcttat ttcacttaga acgttttcaa ggtttatcca     1140

tgtggtagca tgtatcagga actcattgtt tttgtgtctg aataaatttc cactgtatgg     1200

ttaaagcata ctttgtttat ccatttttat gttgataaac atgggttgtt tccacagtaa     1260

taatttgact gctatcaata aggctgctgt ggatgtggta tgtctatgtc tgtgtgagtc     1320

cctgctttca attcttttgg atatatgtat ccctaggagt gtaattgctg gttcacagaa     1380

taattggtgt aaaccttttt caggaacagg tatattgctt tacaaagtgg ctacaatgtt     1440

ttacattctc tccagcaatg cataagggtt tctattttcc acattgtcac atatactggt     1500

tgtcgtattt ttttcataat agccaattaa tggttctgta ctgctttttc attgtggttt     1560

tgatttgcat ttccctaatg accaataata atgcacattg gtttttgttt ttgttggttg     1620

tttatatatt ttttgaacca gtttgtttta aaatcctttg ctcattaaaa ttgagtcatt     1680

tgtgttttgt tgttgagtta taggaattct tatttaaaat ttttagtttt taatatttag     1740

aaaatttctt tcttttttca gctcccaagt gcttggaaga gagttgtagg aattctttat     1800

acactgtggg tattaagccc ttatttgata tgtgatatgc agatgtgttc tccctttctg     1860

taggttttct tttcatcttg agattgtcct ttggtgcgca aaagttttta atttcgatgt     1920

agtccagttt atcttttatt ggttgtctgt gccttaaatg tcgtatccaa taaatcactg     1980

ccaaatttaa                                                            1990


<210>  12
<211>  1965
<212>  DNA
<213>  Homo sapiens

<220>
<223>  ENSG00000247095

<400>  12
gagagggtgc cagcggccgc agctgaagtt gggccgagag ccggcgacgg ccccgcgccg       60

gggtcgcagg cctgcaggag ttgagggctg cacctgctcg ctggagaggg agaggcagat      120

ttagtggacg cctggcatgg actcggactg gcctttggaa gctccctgcc ctgacggggt      180

tgcctgtcac cactgcgaag tgaggcttgg caggacctgc acctgagaaa ggctgtgtgt      240

ggtcttgggg tccacacctg cagagctaac ttactgccag acggcgactt actgtgggcc      300

accctcagtg aaccggggtg tcctcagctg gccctacaga gcacttctgt gctggggatg      360

agtaggaact ctgggcgagg agggtcccag cgccgcccct cgatacagcc tggctctgcc      420

ctctgcccgt acttacacca ggtgggatcc ctgccctgca ttgcctgggg attggctggg      480

cttgggcccg ccctgctgtg gaactggatg ttttcaggga gcccagcctt tcctcatgtc      540

aacacagttc acaatatagt tttcaaagta cagtttaaaa ctcaaaagta aacttttcag      600

caactcaaag gtttgctgag tgatctgaag cactctggcc actttttggg gccatgggat      660

ttggttcacc tgaaacagcc agtgagaggc cgggtgtggt ggctcacacc cgtaatccca      720

acacttcagg aggcagacgc gggtgatcgc tcacttgaga tcaggagttc aagaccagcc      780

tgggcaacat ggtgaaacct cgtctctact aaaaatacaa aaattagcta ggcatggtgg      840

tgggcacctg taatcccagc tacttggaag gctgaggcaa gagaatcgct tgaacctggg      900

aggtggaggt tgcagcgaga cgagattacg ccgctgcact ccagcctggg tgacgagaga      960

ctctgcctca aaaaaataaa aaaatgaaac agccagtgag gaggaaggct ccccgccttc     1020

cccccgccgg aacatagcca tagctgctgc tgggacaccc tcttggtggg gaagaaggct     1080

ggttagcttc atcagagcca gcagcagcag accagggacg ggcacctagg cagtggcctc     1140

agagtgaaca ggagttcctc agaaacacac acagggacgg cgtggcgcat gctctgccag     1200

ctccatgcct ccttcccatt gtggggctgg ggtacgtagg gcagagctca tgacctccgg     1260

gaggacatgg gggtgggctc tggatggcac ctggcattgc cccctgctgg cctatgtgac     1320

ggtgtggagg gctggtcaca gaggtacgac catccctcca gaatgtgggt cggggctgtg     1380

gatggaggag taggcccctc atatcccagg cctgctgccc aggcacaacc cacttggcct     1440

atgcattcca ggctccatcc catgtgactc tgggcttagc cccttctggg gccacaggtc     1500

aggcaggtcc aggccccaag gacctcccag tgacaggcga ctgtgagctg ggcagacagg     1560

agtgaagtca ggtgggggtt ctggcttgct gacaccagcg tttggagcct cctgctgctg     1620

cctggcttcc ctgcattccc tgttccctgc ctcaggcaag aaataaccaa gccgagttgc     1680

ctctgcacag cagtgagctc ctggtggccc tggcttctgg ggagccctgt ggatggcttc     1740

cttgcccaag tccaggcctt cttgttccct ttgtgtgctc cagagaaagg gggcagcacc     1800

agatccagat ccagggccaa ccaacagaaa gctgagtcca tcccaaactc gcccattctc     1860

agagcacaaa gaccccatga tctagggcaa acttgtccaa ctgttggccc atggaacagc     1920

tttgaatgca gcccaacaca aatctataaa ttttcttaaa cattg                     1965


<210>  13
<211>  1389
<212>  DNA
<213>  Homo sapiens

<220>
<223>  ENSG00000223764

<400>  13
ccgagtgcag agccagggcc cagcacgaag gccttgggct ccagtccgtg tgccccacat       60

ccctacatga gtgagggtgg agggatggtg cctctgccac ggccacggtg ccgccgtcca      120

cgtcagctca ctctcagcac aggtgctgtg tgacggcctc gggccacacc gcttgttctg      180

aggcccctag caggtcgggc ttgtgctggc tgcacattgg ctggtgagct tggcgggtct      240

gtgggcacgg agagaccaga acgtgcgtaa caggcccgat gagggtgcca ggctgtggcg      300

acccccgagc ttcagaggag aggggcacca gccgggggcc ctgcacaggc agcctcagag      360

agaggaaagc tcacgatctg ggagaactcc aggcctggcc cagtgaagac gtccttatct      420

tcagcagaca ttgcccagtg caaggggagc cccagactga ctttctgagg tcacagacgg      480

agcctcaccc catccaaggc ggtgtcctgg actcccactg tgctccccag agggcagggt      540

acctggggcc cagcccgggc ggcaggaggg actcagcccc tcgcccaggc aggaagggtc      600

ccaagcagag gcccctccct caggcactcc ccagcccaca cctgcagcac tgggaccaag      660

actaataaaa caccagcctc acggaagaca gctttatctt gttgatcgga agtctgccag      720

cccaatttat gatggaacat aagatctcta aatctgaatt tacgctctgt agcgtaacga      780

gaggtcaata agattaaacg ggggctcagg agaggaccag cgtcaggctc actgcgaggt      840

gctgcacaga aaacccacag ccagagcccc tgggcccagc ccaggcaaga ccagaaaagg      900

agggggcagg tgggagacca gcctggggct cccgggaagc ccacgggatg gaggcgggag      960

agccaggagg cctggggcaa ccctgggacg gttcctggat cgaggagagc aggggggtga     1020

tgagggttcc ctcagggctg gggagccttc tcctggtctc agacccaccc cccttcagct     1080

cccaagccct gggtgcccct ggctctgagg acagttggga atcttccctg aggcaggttc     1140

aaggacagag ctctgaccct ggcccagggc tgctttgggt gcctatgaac tcggcttctg     1200

gctcagagca gttccctgca ccccttcctg agccctctgt cctctggaac ccgtgggcag     1260

ggtgagggac gggtgttcct tctgggtggg ggcctgggcg cccagccagc acgacgctgg     1320

cttgctgagc ttagggcaga ccccgacttc agaatttata caaataaatg caatgaaaag     1380

tgctggcaa                                                             1389


