                         SEQUENCE LISTING

<110>  RNA Guardian
 
<120>  Cancer Biomarker

<130>  P272978WO

<150>  GB 1914096.1
<151>  2019-09-30

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  6652
<212>  DNA
<213>  Homo sapiens

<400>  1
gccagagcca ggaggcagct gtgcgatctg gatgtaccta aaccctccag ggccacatag       60

tgaccccagg ccctggtcac tccatgcttt ggagggtgct tttgtcaaag aggcctcctt      120

tccctcaccc agagctggat ttccaagagg ctcccatacc tagctgccct ggcagactcc      180

cagggaggaa aaacagcgtg gccttggcag ctgccccgag gaaggagccc acaggtgaca      240

gggagaagcc attgccattc cctgtcctgg cccccttcag caaccctgaa cactctgctc      300

cagccaaggt ggtgagggca gctgttccta aacagcgcaa aggcagcaag gttggtgact      360

ttggagatgc aatcaattgg cccacacctg gagagatagc ccacaagagt gttcagccac      420

agtcccacaa gcctcagcct acccgtaaac tgccacccaa gaaggacatg aaggaacagg      480

agaaaggaga agggagtgat agtaaggaga gtccaaaaac caaatcagat gaatcagggg      540

aggaaaagaa tggagatgag gattgccagc gaggcgggca gaagaagaaa ggaaacaaac      600

acaagtgggt tccattacaa atagacatga agcctgaagt gcccagagag aaactggctt      660

cacgccccac tcgcccaccg gagcctagac acatacctgc caatcgcgga gagatcaaag      720

ggtctgagtc tgccacctac gtgcccgtgg ccccccccac cccagcctgg caaccagaga      780

tcaaaccgga gcctgcctgg cacgaccagg atgagacatc gagtgtgaag agtgatgggg      840

ctggtggggc gcgggcttcc ttccgtggcc gtggacgggg gcgtggtcgc ggccggggac      900

gcggccgggg tggcactcga acccattttg actaccagtt tggctaccga aagtttgatg      960

gtgtggaggg gcctcgtacg cccaagtaca tgaacaacat cacctactac tttgacaatg     1020

tcagcagcac cgagctttac agtgtggatc aggaactgct caaagactac atcaagcgcc     1080

agattgaata ctacttcagc gtggacaatt tagagcgaga cttcttcctg cgaaggaaaa     1140

tggatgctga tggtttccta cccatcaccc ttattgcttc cttccaccga gtgcaggccc     1200

ttaccactga catttcactc atctttgcgg ccctaaagga cagcaaggtg gtggagatcg     1260

ttgatgagaa agttcgtagg agggaggaac cagaaaagtg gcctcttccc ccaatagtgg     1320

attattcaca gactgatttc tcccagcttc tcaactgccc tgaatttgtt ccccgtcagc     1380

actaccaaaa ggagacagag tcggcacctg gctctcctcg tgcagtcacc ccagtgccaa     1440

ccaaaacaga ggaggtcagc aacctaaaga cactacccaa gggcctgtct gccagcctgc     1500

ctgacctgga ttctgagaac tggattgaag tgaagaagag gcctcggcca tccccagcac     1560

ggcccaagaa gtcagaggag tccagatttt cccacctgac ctctctgcct cagcagctgc     1620

cttcccagca gctgatgtcc aaggatcagg atgagcaaga ggaactggat tttctgtttg     1680

acgaggagat ggagcagatg gatgggcgga agaacacctt cactgcctgg tctgatgagg     1740

aatctgacta tgagattgat gacagggatg tcaacaagat cctcattgtc acccagacac     1800

cacattacat gcgccggcac ccaggggggg accgcacagg caaccacacc tcgcgtgcca     1860

agatgagcgc cgaactggcc aaggtcatta atgatggcct cttctactat gagcaggacc     1920

tgtgggctga aaagtttgaa cctgagtatt cccagatcaa gcaagaagtc gagaacttca     1980

aaaaggtcaa tatgatcagc cgggagcagt ttgacacact gacccctgag ccccctgtgg     2040

atcccaacca ggaagttcct cctgggccac ctcggttcca gcaagttcct acggatgccc     2100

tggccaacaa gttgtttggt gctcctgagc cctccaccat cgcccgctct ctaccaacca     2160

ctgtcccaga gtcaccaaac taccgcaaca ccaggacccc tcgcactccc cggacaccac     2220

agctcaaaga ctcaagccag acatcacggt tttacccagt ggtgaaagaa ggacggacac     2280

tggatgccaa gatgcctcga aaaagaaaga caagacacag ttcaaaccca cccttggaga     2340

gccatgtggg ctgggtgatg gattcccgtg agcacaggcc ccgtactgct tccatcagct     2400

ccagcccctc agaagggacg cctacagttg gcagctatgg ctgtacccct cagtcattgc     2460

ccaagttcca gcatccttcc catgaactgc tcaaggaaaa tggcttcaca caacacgtct     2520

accataagta tcgtaggcgc tgccttaatg agcggaaacg cttgggcatt ggccagtctc     2580

aggagatgaa cacactcttc cgcttctggt ccttcttcct ccgagatcac ttcaacaaaa     2640

agatgtatga ggagttcaag cagctggctc tggaggacgc caaagaaggc tacagatatg     2700

gtttggagtg cctttttcga tactacagtt atggcctgga aaagaagttc cggctggaca     2760

tattcaagga ttttcaggag gaaacggtga aggactatga agctggccaa ctgtatgggc     2820

tggagaagtt ctgggccttc ttgaaatatt ccaaagccaa aaatttggac attgacccca     2880

aactgcaaga atacctcggc aaattccgac gtcttgaaga cttccgagta gatcccccca     2940

tgggtgagga gggcaaccac aagcgacact cagtggtagc aggaggtggc ggcggtgagg     3000

gcaggaagcg gtgcccctcc cagtcttcca gcaggcctgc tgccatgatc agccaacccc     3060

ctacaccacc caccggccag cctgtccggg aagatgccaa atggacaagc cagcactcga     3120

acacacagac tttgggaaag tgaaaagctc cttagccctg gggcttgagg ggggaaaggg     3180

gtagggtggg taagagtcca tgggggtgcc cagtcccagg agaggggaca atgaagggac     3240

aggcctggag ttactaggac aggcctttgt gctgagtagc aatgtataca ccatttgggc     3300

tatcagaggt acccctgggc aggagcctct acatcccctt ccccctcctc tctccatgac     3360

tcttgacatc ctagcttctt ctaagggggg agggaaaggg gggagatttt tatatatata     3420

tacatatata tatatcaagt tttaaattat tgatagttca tctggattac caaaatcact     3480

ctgcagccct gcccgaggct agtaggctgc aaccctggtc cccaccccta acctcctgct     3540

ccccctcaag ccaactatgc agcccacaag aaggccctgc gggccccccc attgcccagc     3600

actgtctcat agaaggctct ggtggtacct ctgggcccca ggagcatcag ccccttgatc     3660

atctggggtt tgtcatcacc atattttctc cctgctgttc ccaccatgcc cttctgccat     3720

cttctgggag aaggaaacca aaggatctaa aactggggtt tgggggaagg tttcagcctc     3780

tccccactcc ccttgcccca caccctttac tccccagccc agagagacgc tgcttttacc     3840

aggaaagact attgaaagat gttttatttt atttttctct gacctttcca tccttgaaaa     3900

aatggggaaa aaagaagaaa aaagacaaaa tcgaccataa aagaccaaaa aaaaaaaaaa     3960

aatcagaaaa cccccaccta atccacagaa agtaatgtct ttcccctccc cttggaattt     4020

ttgttttgtt tttggaaata atattttttt aaaagttgcc ttattgtgga gcgggaatct     4080

gaaataccca aatgcctgtt ttcctcggtg gagtcaaccc gaagagctcc caccttctct     4140

ggatgtgcct gggcttggac tggctagaat ctttctctgg actgttgcat gtacagtgcc     4200

tccatcctgg aggcaagaga gttgggagtg gctcgaatca gagccgtgcc caagatatcc     4260

ctgctgttgc atcgtttgaa gctgacgtcc tgtgtctgta cactgctgcc actgttgtgt     4320

cctcgctctg cttgctgttg cctcacgcca ggccccgtcc tgccgtgaca cccttcatcc     4380

tacccttgga accccaaggc caagttggtt caaactgttg gagaacagag ttggcctgca     4440

tctggaacac acttgtcctc agcttaccat ctcctcacac cccagagtgg aaaggtgaac     4500

acctgcagct gaggcttgga aacgtttctt gtgttgccct gaaaaatctt tgagacctca     4560

gggaggctct gtctctctta aaaggtggag aaagatgcca ttctctccct aaggtctggt     4620

ggagtctccc catcttgcat acccttctgc aagccatcta tctctgctca ctctccaatt     4680

gacccgcctg ggaacaaggg atgaggagga gttgggggct ggggggaatc ctgccagttg     4740

gtgaagccct gtggcaggaa ggtatatgtg gacatagagt atacctgatt ctctttcttc     4800

agccactgac tgcttgggtt gggctgtgaa tgataatgga atggctggag tctgctgttg     4860

tcagaaggca gggagggtga tgaaggactg acccacatgg actgggatgt gtgtcggtta     4920

tgggcatgac tgcacgttca ctctcagtgg gatctgggca acatggagtt cattgtcctg     4980

ttgcttactt actgcaatgt ctttggccct ccttttcaac tggttcctct gttgggccca     5040

aaggttggga gtaggagaca gtatcccagg ctgacaaggg cttgcccttt accttgggca     5100

ccttgttaat ttttagcctg tgcccttccc cacctttgcc ctcccagtgg ttggtatgtg     5160

ggaagcccat ctcagttcct gtgacttcat gtctcaaacc aaggatgagc gtctggtctc     5220

tgctatgatg gtggtatccg aggcctttcc ctgcccagtc tggtgcctgc cccacattgt     5280

accggacact ggattcctgg acccccttct cctttccttt ctttccttca ggtcacgcag     5340

ccctgtactg tatccagcac cacagaaacc tcagtgtttt tcctctgctg gtttggggca     5400

caaggaagcc ttagggtatg gggaaaggct gttattacct agagtttact cccaggccag     5460

ggggctgcca tcttcttcac agacatccct gaaaggaagc ccctttgggg cagggaggtg     5520

aggacttcat ctcaacatcg gctggtggtt ggtaggggag ctttttcttt tctttccttt     5580

ttttttgttt ttgtttttgt ttttgttttt ggtaacatgt taggagttaa tgttgcaaag     5640

agtagtttac atcttcactt tctgaagaca cttgaattta ggaccgatgt atctgtgaca     5700

agcatgccag aagtggcagg ggccatcagg gctaaccact tcacacctac catcgtccca     5760

tggggatcca agacctgaga taaagcaaca gcctgcccag atccctctgt tcatcctatc     5820

ccttccaagg ttggtccatg ccaacataac ctctgggcat cagacatcag caggtctgtg     5880

tgcctcagcc ctgttaaggg gcaggtttct ctttagccct cttcctgcac ttgggagcaa     5940

aggcactacc agtagagaag ggccatccag ccgtgcccca gcctggaccc ctggggctca     6000

gatagaggtg ctgagcccct gtgtcaaagt tgttaaatgt ttttgttttg ttccattgta     6060

gctctttttt tttttttttc ccctttcctg gtgattgatt ttacaaaaga aagtaagctg     6120

cttagaaggc cctggaaggg aagtgaggag gagggacaag gaagatgact agttacggag     6180

ggtgagggtt gttttttgcc aaaaagcctg ggtagagtga tctgaattat ctggcaccct     6240

cctgaatgga accccagagt acctcctgtg tggaagggtc cctggatttt ccctaacacc     6300

caccctctcc cccttcagcc atgctgatgg cagagaagat aagaacttgg agcccatttc     6360

tcactggaga ggaaaacttg tcatctggct ttgcggagaa ggttccacct tacgctcgta     6420

gtacattatc tttactatgt gctaggatat catatttaaa aggacaaaaa aatgtaaaat     6480

acttgaatga gcttgtatta taacattaat attattgaga gtatctgctt tccaggctga     6540

agtgattcat tcattattct agtcctgctt tagtcctttg taatttgtgg taattatgct     6600

tttcttttta atacaaaaaa atgtataaaa ataaacactt gaaaaggcaa aa             6652


<210>  2
<211>  1019
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Trp Arg Val Leu Leu Ser Lys Arg Pro Pro Phe Pro His Pro 
1               5                   10                  15      


Glu Leu Asp Phe Gln Glu Ala Pro Ile Pro Ser Cys Pro Gly Arg Leu 
            20                  25                  30          


Pro Gly Arg Lys Asn Ser Val Ala Leu Ala Ala Ala Pro Arg Lys Glu 
        35                  40                  45              


Pro Thr Gly Asp Arg Glu Lys Pro Leu Pro Phe Pro Val Leu Ala Pro 
    50                  55                  60                  


Phe Ser Asn Pro Glu His Ser Ala Pro Ala Lys Val Val Arg Ala Ala 
65                  70                  75                  80  


Val Pro Lys Gln Arg Lys Gly Ser Lys Val Gly Asp Phe Gly Asp Ala 
                85                  90                  95      


Ile Asn Trp Pro Thr Pro Gly Glu Ile Ala His Lys Ser Val Gln Pro 
            100                 105                 110         


Gln Ser His Lys Pro Gln Pro Thr Arg Lys Leu Pro Pro Lys Lys Asp 
        115                 120                 125             


Met Lys Glu Gln Glu Lys Gly Glu Gly Ser Asp Ser Lys Glu Ser Pro 
    130                 135                 140                 


Lys Thr Lys Ser Asp Glu Ser Gly Glu Glu Lys Asn Gly Asp Glu Asp 
145                 150                 155                 160 


Cys Gln Arg Gly Gly Gln Lys Lys Lys Gly Asn Lys His Lys Trp Val 
                165                 170                 175     


Pro Leu Gln Ile Asp Met Lys Pro Glu Val Pro Arg Glu Lys Leu Ala 
            180                 185                 190         


Ser Arg Pro Thr Arg Pro Pro Glu Pro Arg His Ile Pro Ala Asn Arg 
        195                 200                 205             


Gly Glu Ile Lys Gly Ser Glu Ser Ala Thr Tyr Val Pro Val Ala Pro 
    210                 215                 220                 


Pro Thr Pro Ala Trp Gln Pro Glu Ile Lys Pro Glu Pro Ala Trp His 
225                 230                 235                 240 


Asp Gln Asp Glu Thr Ser Ser Val Lys Ser Asp Gly Ala Gly Gly Ala 
                245                 250                 255     


Arg Ala Ser Phe Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly Arg Gly 
            260                 265                 270         


Arg Gly Arg Gly Gly Thr Arg Thr His Phe Asp Tyr Gln Phe Gly Tyr 
        275                 280                 285             


Arg Lys Phe Asp Gly Val Glu Gly Pro Arg Thr Pro Lys Tyr Met Asn 
    290                 295                 300                 


Asn Ile Thr Tyr Tyr Phe Asp Asn Val Ser Ser Thr Glu Leu Tyr Ser 
305                 310                 315                 320 


Val Asp Gln Glu Leu Leu Lys Asp Tyr Ile Lys Arg Gln Ile Glu Tyr 
                325                 330                 335     


Tyr Phe Ser Val Asp Asn Leu Glu Arg Asp Phe Phe Leu Arg Arg Lys 
            340                 345                 350         


Met Asp Ala Asp Gly Phe Leu Pro Ile Thr Leu Ile Ala Ser Phe His 
        355                 360                 365             


Arg Val Gln Ala Leu Thr Thr Asp Ile Ser Leu Ile Phe Ala Ala Leu 
    370                 375                 380                 


Lys Asp Ser Lys Val Val Glu Ile Val Asp Glu Lys Val Arg Arg Arg 
385                 390                 395                 400 


Glu Glu Pro Glu Lys Trp Pro Leu Pro Pro Ile Val Asp Tyr Ser Gln 
                405                 410                 415     


Thr Asp Phe Ser Gln Leu Leu Asn Cys Pro Glu Phe Val Pro Arg Gln 
            420                 425                 430         


His Tyr Gln Lys Glu Thr Glu Ser Ala Pro Gly Ser Pro Arg Ala Val 
        435                 440                 445             


Thr Pro Val Pro Thr Lys Thr Glu Glu Val Ser Asn Leu Lys Thr Leu 
    450                 455                 460                 


Pro Lys Gly Leu Ser Ala Ser Leu Pro Asp Leu Asp Ser Glu Asn Trp 
465                 470                 475                 480 


Ile Glu Val Lys Lys Arg Pro Arg Pro Ser Pro Ala Arg Pro Lys Lys 
                485                 490                 495     


Ser Glu Glu Ser Arg Phe Ser His Leu Thr Ser Leu Pro Gln Gln Leu 
            500                 505                 510         


Pro Ser Gln Gln Leu Met Ser Lys Asp Gln Asp Glu Gln Glu Glu Leu 
        515                 520                 525             


Asp Phe Leu Phe Asp Glu Glu Met Glu Gln Met Asp Gly Arg Lys Asn 
    530                 535                 540                 


Thr Phe Thr Ala Trp Ser Asp Glu Glu Ser Asp Tyr Glu Ile Asp Asp 
545                 550                 555                 560 


Arg Asp Val Asn Lys Ile Leu Ile Val Thr Gln Thr Pro His Tyr Met 
                565                 570                 575     


Arg Arg His Pro Gly Gly Asp Arg Thr Gly Asn His Thr Ser Arg Ala 
            580                 585                 590         


Lys Met Ser Ala Glu Leu Ala Lys Val Ile Asn Asp Gly Leu Phe Tyr 
        595                 600                 605             


Tyr Glu Gln Asp Leu Trp Ala Glu Lys Phe Glu Pro Glu Tyr Ser Gln 
    610                 615                 620                 


Ile Lys Gln Glu Val Glu Asn Phe Lys Lys Val Asn Met Ile Ser Arg 
625                 630                 635                 640 


Glu Gln Phe Asp Thr Leu Thr Pro Glu Pro Pro Val Asp Pro Asn Gln 
                645                 650                 655     


Glu Val Pro Pro Gly Pro Pro Arg Phe Gln Gln Val Pro Thr Asp Ala 
            660                 665                 670         


Leu Ala Asn Lys Leu Phe Gly Ala Pro Glu Pro Ser Thr Ile Ala Arg 
        675                 680                 685             


Ser Leu Pro Thr Thr Val Pro Glu Ser Pro Asn Tyr Arg Asn Thr Arg 
    690                 695                 700                 


Thr Pro Arg Thr Pro Arg Thr Pro Gln Leu Lys Asp Ser Ser Gln Thr 
705                 710                 715                 720 


Ser Arg Phe Tyr Pro Val Val Lys Glu Gly Arg Thr Leu Asp Ala Lys 
                725                 730                 735     


Met Pro Arg Lys Arg Lys Thr Arg His Ser Ser Asn Pro Pro Leu Glu 
            740                 745                 750         


Ser His Val Gly Trp Val Met Asp Ser Arg Glu His Arg Pro Arg Thr 
        755                 760                 765             


Ala Ser Ile Ser Ser Ser Pro Ser Glu Gly Thr Pro Thr Val Gly Ser 
    770                 775                 780                 


Tyr Gly Cys Thr Pro Gln Ser Leu Pro Lys Phe Gln His Pro Ser His 
785                 790                 795                 800 


Glu Leu Leu Lys Glu Asn Gly Phe Thr Gln His Val Tyr His Lys Tyr 
                805                 810                 815     


Arg Arg Arg Cys Leu Asn Glu Arg Lys Arg Leu Gly Ile Gly Gln Ser 
            820                 825                 830         


Gln Glu Met Asn Thr Leu Phe Arg Phe Trp Ser Phe Phe Leu Arg Asp 
        835                 840                 845             


His Phe Asn Lys Lys Met Tyr Glu Glu Phe Lys Gln Leu Ala Leu Glu 
    850                 855                 860                 


Asp Ala Lys Glu Gly Tyr Arg Tyr Gly Leu Glu Cys Leu Phe Arg Tyr 
865                 870                 875                 880 


Tyr Ser Tyr Gly Leu Glu Lys Lys Phe Arg Leu Asp Ile Phe Lys Asp 
                885                 890                 895     


Phe Gln Glu Glu Thr Val Lys Asp Tyr Glu Ala Gly Gln Leu Tyr Gly 
            900                 905                 910         


Leu Glu Lys Phe Trp Ala Phe Leu Lys Tyr Ser Lys Ala Lys Asn Leu 
        915                 920                 925             


Asp Ile Asp Pro Lys Leu Gln Glu Tyr Leu Gly Lys Phe Arg Arg Leu 
    930                 935                 940                 


Glu Asp Phe Arg Val Asp Pro Pro Met Gly Glu Glu Gly Asn His Lys 
945                 950                 955                 960 


Arg His Ser Val Val Ala Gly Gly Gly Gly Gly Glu Gly Arg Lys Arg 
                965                 970                 975     


Cys Pro Ser Gln Ser Ser Ser Arg Pro Ala Ala Met Ile Ser Gln Pro 
            980                 985                 990         


Pro Thr Pro Pro Thr Gly Gln Pro  Val Arg Glu Asp Ala  Lys Trp Thr 
        995                 1000                 1005             


Ser Gln  His Ser Asn Thr Gln  Thr Leu Gly Lys 
    1010                 1015                 


<210>  3
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  3

Glu Gly Tyr Arg 
1               


<210>  4
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  4

Leu Asp Ile Phe Lys 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp His Phe Asn Lys 
1               5   


<210>  6
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Trp Ala Phe Leu Lys 
1               5       


<210>  7
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  7

Asn Leu Asp Ile Asp Pro Lys 
1               5           


<210>  8
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  8

Arg Leu Glu Asp Phe Arg 
1               5       


<210>  9
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Gln Glu Tyr Leu Gly Lys 
1               5           


