               SEQUENCE LISTING

<110> Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.

<120> Single domain antibodies specifically binding globo - series glycans

<130> GAR-P04166WO

<160> 228

<170> BiSSAP 1.3.6

<210> 1
<211> 126
<212> PRT
<213> Vicugna pacos


<400> 1
Met Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe 
            20                  25                  30          
Ser Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met 
65                  70                  75                  80  
Val Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Tyr Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr 
            100                 105                 110         
Ile Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 2
<211> 379
<212> DNA
<213> Vicugna pacos


<220> 
<223> nucleic acid

<400> 2
atgggagcac acgtccagct tgtagagtca gggggcggct tagtccagcc aggtggaagt      60

ttacgtctta gttgtgaagg gtcggggatg accttctcta tatacgactt cggttggtat     120

cgtcaggtgc cagggaatca gcgcgagtta gttgcaagca ttggctttgg gggcaacatt     180

gattacgcaa actctgttaa aggacgcttc acgatctccc gtgatggtga caaaaacatg     240

gttagtctgc aaatgaatac gctgcgccca gaggatacag caatttatta ttgcgtggct     300

cgttggacgt tcggaataca gagaggagat tactacatat ggtcgtggaa gcaaggtaca     360

caagtaacag taagttccg                                                  379


<210> 3
<211> 125
<212> PRT
<213> Vicugna pacos


<400> 3
Met Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Ser Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr 
                85                  90                  95      
Tyr Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp 
            100                 105                 110         
His Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210> 4
<211> 375
<212> DNA
<213> Vicugna pacos


<400> 4
atgggagacg ttcaactgca ggaatcgggg ggcggactgg cacagccggg aggctcttta      60

agactgagct gcgccgcctc tggcttcact ttctcctcct atgcgatgag ctgggcacgc     120

caggctccag gaaagggcct ggagtgggta tcgggtatat accgggatgg gatagacact     180

tactacgcgg atagcgtcaa ggggcggttt acgatctctc gtgataatgc caaaaatacc     240

ctgtacctgc aaatgaacag cctgaagcca gaagatacag cgttatatta ttgtgcgaaa     300

gatttactgg cagggtgggg gccattaatc agttggcact actggggtaa ggggacacaa     360

gtaacagtaa gttcc                                                      375


<210> 5
<211> 126
<212> PRT
<213> Vicugna pacos


<400> 5
Met Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30          
Asp Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln 
    50                  55                  60                  
Ser Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Phe Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly 
            100                 105                 110         
Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     

<210> 6
<211> 378
<212> DNA
<213> Vicugna pacos


<400> 6
atgggagatg ttcaactgca agaatctggc ggcggtctgg ttcatccggg cggtagtctg      60

cgtctgtctt gcgttgcgag cggctttacc tttgatgatt atgcgctgac ctgggttcgt     120

caagcaccgg gtaaaggtct ggagtgggta tctggtatca actggaacgg cgacgatacc     180

tactacaccc aaagcatgaa aggccgcttt accatcagtc gcgataacgc gaaaaacacc     240

ctgtacctgc agatgaacag cctgaaaagc gaagacaccg cggtttactt ctgcaccaaa     300

aacgtcggcg gtaattgggt ttctggggat tacggtctgg attattgggg tcagggtacc     360

caagttaccg ttagttct                                                   378


<210> 7
<211> 123
<212> PRT
<213> Vicugna pacos


<400> 7
Met Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly 
            20                  25                  30          
Asn His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Trp Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr 
            100                 105                 110         
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             

<210> 8
<211> 371
<212> DNA
<213> Vicugna pacos


<400> 8
atgggagatg ttcaactggt tgaatctggc ggcggtctgg ttcaaccggg cggtagtctg      60

cgtctgtctt gtaccgcaag cggttttacc tttggcaacc actggatgta ctgggttcgt     120

caaaccccgg gtaaaggtct ggagtgggtt gcaaccgcaa ataccggcgg tcgcgatacc     180

tattatgcag atagcgtctg gggtcgtttt accatttctg gcgataacgc gaaaaacacc     240

ctgtacctgc agatgaacaa cctgaaaagc gaggacaccg cgatctatta ttgcgcacgc     300

gaagttaacg actacctgga atacgcgctg ggttattggg gtcaaggtac ccaagttacc     360

gttagctctg g                                                          371


<210> 9
<211> 125
<212> PRT
<213> Vicugna pacos


<400> 9
Met Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Ser Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              
Cys Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met 
            100                 105                 110         
Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 

<210> 10
<211> 375
<212> DNA
<213> Vicugna pacos


<400> 10
atgggtgacg ttcaactggt tgaatctggc ggcggtctgg ttcaaccggg cggtagtctg      60

cgtctgagtt gcgcagcatc tggttttacc ttctcctcct actggatgca ttgggttcgt     120

caagcaccgg gtaaaggtct ggagtgcgtc agcgttatta ataccggcaa cggtagtccg     180

tactacgcgg atagcgttaa aggccgtttc accatcagca ccgataacgc gaaaaacacc     240

ctgtacctgc agatgaacag cctgaaaagc gaagataccg cggtttatta ttgcgcacgc     300

gatattccgg atccggcagg tcgcgctggc ggtatggatt attggggtaa aggcacccag     360

gttaccgtta gcagc                                                      375


<210> 11
<211> 121
<212> PRT
<213> Vicugna pacos


<400> 11
Met Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn 
65                  70                  75                  80  
Val Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys 
                85                  90                  95      
Tyr Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly 
            100                 105                 110         
Gln Glu Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210> 12
<211> 365
<212> DNA
<213> Vicugna pacos


<400> 12
atgggtgcgc aagttcagct ggttgaatct ggcggtggtc tggttcaacc gggcggtagt      60

ctgaccgtta gttgcgcagc atctggtttt acctttagcc gttacggcgt tacctggcat     120

cgtcaagcac cgggtaaaga acgcgaactg gttgcggata tcatctttac cggcctgaac     180

ccgacctata gcgatagcgt taaaggtcgt ttcaccatca gccgcgataa cgacaaaaac     240

gtcgcctacc tgcagatgaa cagcctgaaa ccggaagata ccgcgaaata ctactgcaac     300

gtcaacgata tcgtcgttcg cggcaactat tggggtcaag aaacccaggt taccgtttct     360

agtgg                                                                 365


<210> 13
<211> 122
<212> PRT
<213> Vicugna pacos


<400> 13
Met Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu 
            20                  25                  30          
Gly Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg 
        35                  40                  45              
Glu Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met 
65                  70                  75                  80  
Val Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr 
                85                  90                  95      
Tyr Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         

<210> 14
<211> 368
<212> DNA
<213> Vicugna pacos


<400> 14
atgggcgcgg acgttaaact ggttgaatct ggcggtggtc tggttcaacc gggcggtagt      60

ctgcgtctga gttgcgcagt ttctggtacc attctgggcc tgaacatgat gggttggtat     120

cgtcaagcac cgggtaaaca acgcgaactg gttgcgagca ttggctttgg cggtaacatt     180

gattacgcga acagcgtcaa aggccgtttt accattagtc gcgacggcga caaaaacatg     240

gtctctctgc agatgaatac cctgcgtccg gaagataccg cgatttatta ctgcgtcgcg     300

cgttggacct ttggtattca acgcggcgat tattggggtc aaggtaccca ggttaccgtt     360

agcagtgg                                                              368


<210> 15
<211> 131
<212> PRT
<213> Vicugna pacos


<400> 15
Met Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 
            20                  25                  30          
Ser Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro 
        35                  40                  45              
Glu Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr 
            100                 105                 110         
Gly Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
        115                 120                 125             
Val Ser Ser 
    130     

<210> 16
<211> 393
<212> DNA
<213> Vicugna pacos


<400> 16
atgggcgcag acgttcaact ggttgaatct ggcggtggta tggttcaacc gggcggtagt      60

ctgcgtctga gttgcgcagc atctggtttt atcttctccc gccacgatat gcattgggta     120

cgtcaaggtc cgggtaaagg tccggaatgg gttagtctga ttaccaccgg cggcgaaggt     180

acctggtacg ttgatagcgt caaaggtcgt ttcagcatca gccgcgataa cgcgaaaaac     240

accgtctacc tgcagatgaa cgcactgaaa ccggaagata ccgcagttta ctattgcgca     300

gcacatcgcg cagaaattcc gcgcgaaatt tgctacggcg atagcctgag ctacaactat     360

tggggtcagg gtacccaagt taccgtttct agt                                  393


<210> 17
<211> 128
<212> PRT
<213> Vicugna pacos


<400> 17
Met Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Leu Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu 
            20                  25                  30          
Gln Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        35                  40                  45              
Glu Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val 
                85                  90                  95      
Tyr Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro 
            100                 105                 110         
Ala His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             



<210> 18
<211> 386
<212> DNA
<213> Vicugna pacos


<400> 18
atgggtgcgc aagttcagct ggttgaatct ggcggtggtc tggttcaact gggcggtagt      60

ctgcgtctga gttgtaccgc aagcgaaatt gacctgcagt actacccgat tgcttggttt     120

cgtcaagctc cgggtaaaga acgcgaaggc gttagttgta ttcgcgcaac cgatagcggt     180

acctattacg cggatagcgt caaaggtcgt ttcaccattg cgcgcgataa cgcgaaaaac     240

accgtctacc tgcagatgaa caatctggca ccggaagata ccgctgttta ctattgcggt     300

accgacgata gcgaagattg caccgattac gcaccggcac attacggtta ttggggtcgc     360

ggtacccaag ttaccgttag tagtgg                                          386


<210> 19
<211> 167
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 19
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser 
    130                 135                 140                 
Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile 
145                 150                 155                 160 
Val Pro Ile Ile Arg Ile Gly 
                165         

<210> 20
<211> 172
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 20
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
145                 150                 155                 160 
Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170         

<210> 21
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 21
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val 
    130                 135                 140                 
Tyr Arg Gly Ile Tyr Arg 
145                 150 

<210> 22
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 22
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155 

<210> 23
<211> 158
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide Polybia-MP1

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 23
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155             

<210> 24
<211> 166
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 24
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu 
    130                 135                 140                 
Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val 
145                 150                 155                 160 
Pro Ile Ile Arg Ile Gly 
                165     

<210> 25
<211> 171
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 25
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr 
145                 150                 155                 160 
Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170     

<210> 26
<211> 149
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 26
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr 
    130                 135                 140                 
Arg Gly Ile Tyr Arg 
145                 

<210> 27
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 27
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys 
    130                 135                 140                 
Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 

<210> 28
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 28
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile 
    130                 135                 140                 
Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155         

<210> 29
<211> 167
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 29
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser 
    130                 135                 140                 
Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile 
145                 150                 155                 160 
Val Pro Ile Ile Arg Ile Gly 
                165         

<210> 30
<211> 172
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 30
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
145                 150                 155                 160 
Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170         

<210> 31
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 31
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val 
    130                 135                 140                 
Tyr Arg Gly Ile Tyr Arg 
145                 150 

<210> 32
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 32
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155 

<210> 33
<211> 158
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 33
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
    130                 135                 140                 
Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155             

<210> 34
<211> 164
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 34
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg 
    130                 135                 140                 
Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile 
145                 150                 155                 160 
Ile Arg Ile Gly 
                

<210> 35
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 35
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly Gly Leu 
    130                 135                 140                 
Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro 
145                 150                 155                 160 
Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 

<210> 36
<211> 147
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 36
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly 
    130                 135                 140                 
Ile Tyr Arg 
145         

<210> 37
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 37
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp Phe 
    130                 135                 140                 
Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150         

<210> 38
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 38
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile Asp Trp 
    130                 135                 140                 
Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155 

<210> 39
<211> 166
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 39
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu 
    130                 135                 140                 
Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val 
145                 150                 155                 160 
Pro Ile Ile Arg Ile Gly 
                165     

<210> 40
<211> 171
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 40
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 
Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr 
145                 150                 155                 160 
Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170     

<210> 41
<211> 149
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 41
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr 
    130                 135                 140                 
Arg Gly Ile Tyr Arg 
145                 

<210> 42
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 42
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys 
    130                 135                 140                 
Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 

<210> 43
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 43
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile 
    130                 135                 140                 
Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155         

<210> 44
<211> 162
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 44
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile 
    130                 135                 140                 
Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg 
145                 150                 155                 160 
Ile Gly 
        

<210> 45
<211> 167
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 45
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser 
    130                 135                 140                 
Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile 
145                 150                 155                 160 
Val Pro Ile Ile Arg Ile Gly 
                165         

<210> 46
<211> 145
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 46
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr 
    130                 135                 140                 
Arg 
145 

<210> 47
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 47
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp Phe Arg Val 
    130                 135                 140                 
Tyr Arg Gly Ile Tyr Arg 
145                 150 

<210> 48
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide Polybia-MP1

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 48
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys 
    130                 135                 140                 
Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150             

<210> 49
<211> 163
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 49
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys 
    130                 135                 140                 
Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile 
145                 150                 155                 160 
Arg Ile Gly 
            

<210> 50
<211> 168
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 50
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly Gly Leu Arg 
    130                 135                 140                 
Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile 
145                 150                 155                 160 
Ile Val Pro Ile Ile Arg Ile Gly 
                165             

<210> 51
<211> 146
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 51
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly Ile 
    130                 135                 140                 
Tyr Arg 
145     

<210> 52
<211> 151
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 52
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp Phe Arg 
    130                 135                 140                 
Val Tyr Arg Gly Ile Tyr Arg 
145                 150     

<210> 53
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 53
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile Asp Trp Lys 
    130                 135                 140                 
Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 

<210> 54
<211> 172
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 54
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
145                 150                 155                 160 
Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170         

<210> 55
<211> 177
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 55
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
    130                 135                 140                 
Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu 
145                 150                 155                 160 
Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile 
                165                 170                 175     
Gly 
    

<210> 56
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 56
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155 

<210> 57
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 57
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
    130                 135                 140                 
Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155                 160 



<210> 58
<211> 163
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 58
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys 
    130                 135                 140                 
Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys 
145                 150                 155                 160 
Gln Ile Leu 
            

<210> 59
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 59
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu 
    130                 135                 140                 
Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro 
145                 150                 155                 160 
Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 

<210> 60
<211> 174
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 60
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly 
    130                 135                 140                 
Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp 
145                 150                 155                 160 
Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170                 

<210> 61
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 61
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe 
    130                 135                 140                 
Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150         

<210> 62
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 62
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly 
    130                 135                 140                 
Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155         

<210> 63
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 63
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly 
    130                 135                 140                 
Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155                 160 



<210> 64
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb26

<400> 64
Ile Tyr Asp Phe Gly 
1               5   

<210> 65
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb37

<400> 65
Ser Tyr Ala Met Ser 
1               5   

<210> 66
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb46

<400> 66
Asp Tyr Ala Leu Thr 
1               5   

<210> 67
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb47

<400> 67
Asn His Trp Met Tyr 
1               5   

<210> 68
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb56

<400> 68
Ser Tyr Trp Met His 
1               5   

<210> 69
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb59

<400> 69
Arg Tyr Gly Val Thr 
1               5   

<210> 70
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb62

<400> 70
Leu Asn Met Met Gly 
1               5   

<210> 71
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb63

<400> 71
Arg His Asp Met His 
1               5   

<210> 72
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb65

<400> 72
Tyr Tyr Pro Ile Ala 
1               5   

<210> 73
<211> 16
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb26

<400> 73
Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      



<210> 74
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb37

<400> 74
Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 75
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb46

<400> 75
Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser Met Lys 
1               5                   10                  15      
Gly 
    

<210> 76
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb47

<400> 76
Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val Trp 
1               5                   10                  15      
Gly 
    

<210> 77
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb56

<400> 77
Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 78
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb59

<400> 78
Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 79
<211> 16
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb62

<400> 79
Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser Val Lys Gly 
1               5                   10                  15      



<210> 80
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb63

<400> 80
Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 81
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb65

<400> 81
Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 82
<211> 15
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb26

<400> 82
Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile Trp Ser 
1               5                   10                  15  

<210> 83
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb37

<400> 83
Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His Tyr 
1               5                   10                  

<210> 84
<211> 15
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb46

<400> 84
Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu Asp Tyr 
1               5                   10                  15  

<210> 85
<211> 12
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb47

<400> 85
Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr 
1               5                   10          

<210> 86
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb56

<400> 86
Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp Tyr 
1               5                   10                  

<210> 87
<211> 9
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb59

<400> 87
Asn Asp Ile Val Val Arg Gly Asn Tyr 
1               5                   

<210> 88
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb62

<400> 88
Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr 
1               5                   10      

<210> 89
<211> 19
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb63

<400> 89
His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly Asp Ser Leu Ser 
1               5                   10                  15      
Tyr Asn Tyr 
            

<210> 90
<211> 16
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb65

<400> 90
Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala His Tyr Gly Tyr 
1               5                   10                  15      



<210> 91
<211> 33
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb26

<400> 91
Met Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe 
            20                  25                  30          
Ser 
    

<210> 92
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb37

<400> 92
Met Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          



<210> 93
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb46

<400> 93
Met Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp 
            20                  25                  30          



<210> 94
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb47

<400> 94
Met Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly 
            20                  25                  30          



<210> 95
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb56

<400> 95
Met Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          



<210> 96
<211> 33
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb59

<400> 96
Met Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser 
    

<210> 97
<211> 33
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb62

<400> 97
Met Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu 
            20                  25                  30          
Gly 
    

<210> 98
<211> 33
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb63

<400> 98
Met Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe 
            20                  25                  30          
Ser 
    

<210> 99
<211> 33
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb65

<400> 99
Met Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Leu Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu 
            20                  25                  30          
Gln 
    

<210> 100
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb26

<400> 100
Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu Leu Val Ala 
1               5                   10                  

<210> 101
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb37

<400> 101
Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 102
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb46

<400> 102
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 103
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb47

<400> 103
Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp Val Ala 
1               5                   10                  

<210> 104
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb56

<400> 104
Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Val Ser 
1               5                   10                  

<210> 105
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb59

<400> 105
Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu Leu Val Ala 
1               5                   10                  

<210> 106
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb62

<400> 106
Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
1               5                   10                  

<210> 107
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb63

<400> 107
Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu Trp Val Ser 
1               5                   10                  

<210> 108
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb65

<400> 108
Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val Ser 
1               5                   10                  

<210> 109
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb26

<400> 109
Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val Ser Leu Gln 
1               5                   10                  15      
Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Val Ala 
            20                  25                  30          



<210> 110
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb37

<400> 110
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys 
            20                  25                  30          



<210> 111
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb46

<400> 111
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe Cys Thr Lys 
            20                  25                  30          



<210> 112
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb47

<400> 112
Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 113
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb56

<400> 113
Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 114
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb59

<400> 114
Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val Ala Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr Tyr Cys Asn Val 
            20                  25                  30          



<210> 115
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb62

<400> 115
Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val Ser Leu Gln 
1               5                   10                  15      
Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr Cys Val Ala 
            20                  25                  30          



<210> 116
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb63

<400> 116
Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            20                  25                  30          



<210> 117
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb65

<400> 117
Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
1               5                   10                  15      
Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr Tyr Cys Gly Thr 
            20                  25                  30          



<210> 118
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb26

<400> 118
Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 119
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb37

<400> 119
Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 120
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb46

<400> 120
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 121
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb47

<400> 121
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 122
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb56

<400> 122
Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 123
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb59

<400> 123
Trp Gly Gln Glu Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 124
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb62

<400> 124
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 125
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb63

<400> 125
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 126
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb65

<400> 126
Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 127
<211> 10
<212> PRT
<213> Artificial Sequence


<220> 
<223> GS_linker used as linker between the sdAb and the lytic peptide

<220> 
<221> SITE
<222> 3,4
<223> Xaa can be any amino acid

<400> 127
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  

<210> 128
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> GSAA_linker used as linker between the sdAb and the lytic peptide

<220> 
<221> SITE
<222> 3,4
<223> Xaa can be any amino acid

<400> 128
Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser 
1               5                   10                  15  

<210> 129
<211> 28
<212> PRT
<213> Bos taurus


<220> 
<223> BMAP28A

<400> 129
Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
1               5                   10                  15      
Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
            20                  25              

<210> 130
<211> 11
<212> PRT
<213> Artificial Sequence


<220> 
<223> Modified Cysteine deleted Tachyplesin-I

<400> 130
Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
1               5                   10      

<210> 131
<211> 14
<212> PRT
<213> Polybia paulista


<220> 
<223> Polybia-MP1

<400> 131
Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
1               5                   10                  

<210> 132
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer CALL001 used to PCR amplify the VHH variable regions

<400> 132
gtcctggctg ctcttctaca agg                                            23


<210> 133
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer CALL002 used to PCR amplify the VHH variable regions

<400> 133
ggtacgtgct gttgaactgt tcc                                            23


<210> 134
<211> 29
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer VHH_back used to PCR amplify the VHH variable regions

<400> 134
gatgtgcagc tgcaggagtc tggrggagg                                      29


<210> 135
<211> 33
<212> DNA
<213> Artificial Sequence


<220> 
<223> Primer VHH_for used to PCR amplify the VHH variable regions

<400> 135
ggactagtgc ggccgctgga gacggtgacc tgg                                  33


<210> 136
<211> 121
<212> PRT
<213> Vicugna pacos


<220> 
<223> sdAb14 amino acid sequence

<400> 136
Met Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala 
1               5                   10                  15      
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val 
            20                  25                  30          
Phe Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              
Leu Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr 
    50                  55                  60                  
Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  
Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala 
                85                  90                  95      
Val Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     

<210> 137
<211> 129
<212> PRT
<213> Vicugna pacos


<220> 
<223> sdAb60 amino acid sequence

<400> 137
Met Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val 
1               5                   10                  15      
Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser 
            20                  25                  30          
Ile Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu 
        35                  40                  45              
Lys Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr 
    50                  55                  60                  
Tyr Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser 
65                  70                  75                  80  
Arg Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr 
                85                  90                  95      
Ala Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys 
            100                 105                 110         
Phe Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             
Ser 
    

<210> 138
<211> 124
<212> PRT
<213> Vicugna pacos


<220> 
<223> sdAbS amino acid sequence

<400> 138
Met Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val 
1               5                   10                  15      
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          
Phe Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly 
        35                  40                  45              
Leu Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr 
    50                  55                  60                  
Ala Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys 
65                  70                  75                  80  
His Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala 
                85                  90                  95      
Leu Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         
Gly Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser 
        115                 120                 

<210> 139
<211> 363
<212> DNA
<213> Vicugna pacos


<220> 
<223> sdAb14 nucleic acid sequence

<400> 139
atgggaatgg ccgaggtgga ggtggtggcg tctgggggag acttggcgca gcctgggggg      60

tctctgagac tctcctgtgc agcctctgga ttcgtcttca gtagctatgc catgatctgg     120

gcccgccagg ctccaggaaa ggggctcgag tgggtgtccg gtattaatag tgatgctagt     180

ggcacatggt atgctgactc cgtgaagggc cgattcacta tctccagaga caacgccaag     240

aacacgttgt atctgcaaat gaacagcctg aaacctgatg acacggccgt gtatttctgt     300

cttcatagtg gtcatactca cacgcgctac tggggccagg ggacccaggt caccgtctcc     360

tcg                                                                   363


<210> 140
<211> 387
<212> DNA
<213> Vicugna pacos


<220> 
<223> sdAb60 nucleic acid sequence

<400> 140
atgggaatgg ccgaggtgga ggtggtggcg tcgggcccag gcctggtgaa accctcgcag      60

acactctccc tcacctgcac tgtctctggt gactccatca caaccacatt ttctcactgg     120

acctggatcc gccagtcccc agagaagggg ctggagtgga tgggagccat aggttatggt     180

ggcagtattt attacagccc atccttcaag agccgcactt ccatctccag ggacacgtcc     240

aggaaccaat ttaccctgca cctgtcatca gtgactcctg aagacacagc cgtctattac     300

tgtgccagac tcccccatag tagtggctat gccaagttcg gccaccttga ctactggggc     360

caggggaccc aggtcactgt ctcctcc                                         387


<210> 141
<211> 372
<212> DNA
<213> Vicugna pacos


<220> 
<223> sdAbS nucleic acid sequence

<400> 141
atgggaatgg ccgaggtgga ggtggtggcg tctgggggag gcttggtgca gcctgggggg      60

tctctaagac tctcctgtgc agcctctgga ttcaccttca gtaactactg gatgtattgg     120

gcccgtcagg ctccagggaa ggggctcgag tgggtgtcag ctatagatca gagtggtact     180

accacaagat atgcagactc cgtgaagggc caattcacca tctctagaga caacgccaag     240

cacacgctgt atctgcaaat gaacagcctg aaacctgagg acacggccct gtattactgt     300

acgacctcag gcaggtacta cgccatggac tactggggca aagggaccca ggtcactgtc     360

tccacatcgt cg                                                         372


<210> 142
<211> 162
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 14 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 142
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile 
    130                 135                 140                 
Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg 
145                 150                 155                 160 
Ile Gly 
        

<210> 143
<211> 167
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 14_ linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 143
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser 
    130                 135                 140                 
Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile 
145                 150                 155                 160 
Val Pro Ile Ile Arg Ile Gly 
                165         

<210> 144
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 14 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 144
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp Phe Arg Val 
    130                 135                 140                 
Tyr Arg Gly Ile Tyr Arg 
145                 150 

<210> 145
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 14 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 145
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp Phe Arg Val 
    130                 135                 140                 
Tyr Arg Gly Ile Tyr Arg 
145                 150 

<210> 146
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 14_ linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 146
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys 
    130                 135                 140                 
Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150             

<210> 147
<211> 170
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 147
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly 
145                 150                 155                 160 
Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170 

<210> 148
<211> 175
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60_ linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 148
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly 
    130                 135                 140                 
Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala 
145                 150                 155                 160 
Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170                 175 

<210> 149
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 149
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp 
    130                 135                 140                 
Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150             

<210> 150
<211> 158
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 150
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly 
    130                 135                 140                 
Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155             

<210> 151
<211> 161
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60_ linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 151
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly 
    130                 135                 140                 
Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile 
145                 150                 155                 160 
Leu 
    

<210> 152
<211> 165
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS_ linked to the lytic peptide BMAP28A by a GS_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 152
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Arg Ser Leu Gly 
    130                 135                 140                 
Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro 
145                 150                 155                 160 
Ile Ile Arg Ile Gly 
                165 

<210> 153
<211> 170
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS_ linked to the lytic peptide BMAP28A by a GSAA_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 153
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Gly Gly 
    130                 135                 140                 
Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly 
145                 150                 155                 160 
Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170 

<210> 154
<211> 148
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GS_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 154
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Trp Phe Arg Val Tyr Arg 
    130                 135                 140                 
Gly Ile Tyr Arg 
145             

<210> 155
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a GSAA_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 155
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Lys Trp 
    130                 135                 140                 
Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150             

<210> 156
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS_ linked to the lytic peptide Polybia-MP1 by a GSAA_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 156
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Glu Ala Ala Ala Lys Gly Gly Gly Gly Ser Ile Asp 
    130                 135                 140                 
Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155     

<210> 157
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb14

<400> 157
Ser Tyr Ala Met Ile 
1               5   

<210> 158
<211> 7
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAb60

<400> 158
Thr Thr Phe Ser His Trp Thr 
1               5           

<210> 159
<211> 5
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR1 of sdAbS

<400> 159
Asn Tyr Trp Met Tyr 
1               5   

<210> 160
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb14

<400> 160
Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 161
<211> 16
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAb60

<400> 161
Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr Ser Pro Ser Phe Lys Ser 
1               5                   10                  15      



<210> 162
<211> 17
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR2 of sdAbS

<400> 162
Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      
Gly 
    

<210> 163
<211> 8
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb14

<400> 163
Ser Gly His Thr His Thr Arg Tyr 
1               5               

<210> 164
<211> 13
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAb60

<400> 164
Leu Pro His Ser Ser Gly Tyr Ala Lys Phe Gly His Leu 
1               5                   10              

<210> 165
<211> 7
<212> PRT
<213> Vicugna pacos


<220> 
<223> CDR3 of sdAbS

<400> 165
Ser Gly Arg Tyr Tyr Ala Met 
1               5           

<210> 166
<211> 34
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb14

<400> 166
Met Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala 
1               5                   10                  15      
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val 
            20                  25                  30          
Phe Ser 
        

<210> 167
<211> 35
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAb60

<400> 167
Met Gly Met Ala Glu Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu 
1               5                   10                  15      
Val Lys Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp 
            20                  25                  30          
Ser Ile Thr 
        35  

<210> 168
<211> 34
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR1 of sdAbS

<400> 168
Met Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val 
1               5                   10                  15      
Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
            20                  25                  30          
Phe Ser 
        

<210> 169
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb14

<400> 169
Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 170
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAb60

<400> 170
Trp Ile Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Met Gly 
1               5                   10                  

<210> 171
<211> 14
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR2 of sdAbS

<400> 171
Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
1               5                   10                  

<210> 172
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb14

<400> 172
Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val Tyr Phe Cys Leu His 
            20                  25                  30          



<210> 173
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAb60

<400> 173
Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg Asn Gln Phe Thr Leu His 
1               5                   10                  15      
Leu Ser Ser Val Thr Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
            20                  25                  30          



<210> 174
<211> 32
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR3 of sdAbS

<400> 174
Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His Thr Leu Tyr Leu Gln 
1               5                   10                  15      
Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys Thr Thr 
            20                  25                  30          



<210> 175
<211> 11
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb14

<400> 175
Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10      

<210> 176
<211> 13
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAb60

<400> 176
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
1               5                   10              

<210> 177
<211> 15
<212> PRT
<213> Vicugna pacos


<220> 
<223> FR4 of sdAbS

<400> 177
Asp Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser 
1               5                   10                  15  

<210> 178
<211> 17
<212> PRT
<213> Artificial Sequence


<220> 
<223> SRGS_linker used as linker between the sdAb and the lytic peptide

<220> 
<221> SITE
<222> 3,4
<223> Xaa can be any amino acid

<400> 178
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
1               5                   10                  15      
Gly 
    

<210> 179
<211> 174
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide BMAP28A by a SRGS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 179
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp 
145                 150                 155                 160 
Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170                 

<210> 180
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb26 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 180
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155         

<210> 181
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 26 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 181
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys 
    130                 135                 140                 
Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150             

<210> 182
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 26 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 182
Gly Ala His Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Glu Gly Ser Gly Met Thr Phe Ser 
            20                  25                  30          
Ile Tyr Asp Phe Gly Trp Tyr Arg Gln Val Pro Gly Asn Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Tyr Ile 
            100                 105                 110         
Trp Ser Trp Lys Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155                 160 



<210> 183
<211> 173
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 183
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys 
145                 150                 155                 160 
Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170             

<210> 184
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 37 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 184
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155     

<210> 185
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb 37 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 185
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu 
    130                 135                 140                 
Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150         

<210> 186
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb37 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 186
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Ala Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Ala Met Ser Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Tyr Arg Asp Gly Ile Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr 
                85                  90                  95      
Cys Ala Lys Asp Leu Leu Ala Gly Trp Gly Pro Leu Ile Ser Trp His 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155                 

<210> 187
<211> 174
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 187
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp 
145                 150                 155                 160 
Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170                 

<210> 188
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 188
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155         

<210> 189
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 189
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys 
    130                 135                 140                 
Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150             

<210> 190
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb46 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 128,129
<223> Xaa can be any amino acid

<400> 190
Gly Asp Val Gln Leu Gln Glu Ser Gly Gly Gly Leu Val His Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Asp 
            20                  25                  30          
Tyr Ala Leu Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ser Gly Ile Asn Trp Asn Gly Asp Asp Thr Tyr Tyr Thr Gln Ser 
    50                  55                  60                  
Met Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Phe 
                85                  90                  95      
Cys Thr Lys Asn Val Gly Gly Asn Trp Val Ser Gly Asp Tyr Gly Leu 
            100                 105                 110         
Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa 
        115                 120                 125             
Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly 
    130                 135                 140                 
Ser Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155                 160 



<210> 191
<211> 171
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 191
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg 
        115                 120                 125             
Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Gly 
    130                 135                 140                 
Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr 
145                 150                 155                 160 
Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170     

<210> 192
<211> 154
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 192
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg 
        115                 120                 125             
Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Lys 
    130                 135                 140                 
Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 

<210> 193
<211> 150
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 193
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly 
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp 
    130                 135                 140                 
Ala Ala Lys Gln Ile Leu 
145                 150 

<210> 194
<211> 157
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb47 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 125,126
<223> Xaa can be any amino acid

<400> 194
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Gly Asn 
            20                  25                  30          
His Trp Met Tyr Trp Val Arg Gln Thr Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              
Val Ala Thr Ala Asn Thr Gly Gly Arg Asp Thr Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Trp Gly Arg Phe Thr Ile Ser Gly Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Asn Leu Lys Ser Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Glu Val Asn Asp Tyr Leu Glu Tyr Ala Leu Gly Tyr Trp 
            100                 105                 110         
Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg 
        115                 120                 125             
Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Ile 
    130                 135                 140                 
Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155         

<210> 195
<211> 173
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 195
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys 
145                 150                 155                 160 
Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170             

<210> 196
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 196
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155     

<210> 197
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 197
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu 
    130                 135                 140                 
Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150         

<210> 198
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb56 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 127,128
<223> Xaa can be any amino acid

<400> 198
Gly Asp Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser 
            20                  25                  30          
Tyr Trp Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys 
        35                  40                  45              
Val Ser Val Ile Asn Thr Gly Asn Gly Ser Pro Tyr Tyr Ala Asp Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Thr Asp Asn Ala Lys Asn Thr Leu 
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      
Cys Ala Arg Asp Ile Pro Asp Pro Ala Gly Arg Ala Gly Gly Met Asp 
            100                 105                 110         
Tyr Trp Gly Lys Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa 
        115                 120                 125             
Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser 
    130                 135                 140                 
Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155                 

<210> 199
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 199
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Gly Gly Leu 
    130                 135                 140                 
Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro 
145                 150                 155                 160 
Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 

<210> 200
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 200
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Lys Trp Phe 
    130                 135                 140                 
Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150         

<210> 201
<211> 148
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 201
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala 
    130                 135                 140                 
Lys Gln Ile Leu 
145             

<210> 202
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb59 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 202
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Thr Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          
Arg Tyr Gly Val Thr Trp His Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Leu Val Ala Asp Ile Ile Phe Thr Gly Leu Asn Pro Thr Tyr Ser Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Asp Lys Asn Val 
65                  70                  75                  80  
Ala Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Lys Tyr 
                85                  90                  95      
Tyr Cys Asn Val Asn Asp Ile Val Val Arg Gly Asn Tyr Trp Gly Gln 
            100                 105                 110         
Glu Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Ile Asp Trp 
    130                 135                 140                 
Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155 

<210> 203
<211> 170
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 203
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly 
        115                 120                 125             
Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 
Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly 
145                 150                 155                 160 
Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170 

<210> 204
<211> 153
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 204
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly 
        115                 120                 125             
Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Lys Trp 
    130                 135                 140                 
Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150             

<210> 205
<211> 149
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 205
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly 
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala 
    130                 135                 140                 
Ala Lys Gln Ile Leu 
145                 

<210> 206
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb62 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 124,125
<223> Xaa can be any amino acid

<400> 206
Gly Ala Asp Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Thr Ile Leu Gly 
            20                  25                  30          
Leu Asn Met Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
        35                  40                  45              
Leu Val Ala Ser Ile Gly Phe Gly Gly Asn Ile Asp Tyr Ala Asn Ser 
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Gly Asp Lys Asn Met Val 
65                  70                  75                  80  
Ser Leu Gln Met Asn Thr Leu Arg Pro Glu Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      
Cys Val Ala Arg Trp Thr Phe Gly Ile Gln Arg Gly Asp Tyr Trp Gly 
            100                 105                 110         
Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly 
        115                 120                 125             
Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Ile Asp 
    130                 135                 140                 
Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155     

<210> 207
<211> 179
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 207
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 
Gly Ser Ser Gly Gly Ser Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys 
145                 150                 155                 160 
Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile 
                165                 170                 175     
Arg Ile Gly 
            

<210> 208
<211> 162
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 208
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 
Gly Ser Ser Gly Gly Ser Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile 
145                 150                 155                 160 
Tyr Arg 
        

<210> 209
<211> 158
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 209
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 
Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155             

<210> 210
<211> 165
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb63 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 133,134
<223> Xaa can be any amino acid

<400> 210
Gly Ala Asp Val Gln Leu Val Glu Ser Gly Gly Gly Met Val Gln Pro 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser 
            20                  25                  30          
Arg His Asp Met His Trp Val Arg Gln Gly Pro Gly Lys Gly Pro Glu 
        35                  40                  45              
Trp Val Ser Leu Ile Thr Thr Gly Gly Glu Gly Thr Trp Tyr Val Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Ser Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Ala Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Ala Ala His Arg Ala Glu Ile Pro Arg Glu Ile Cys Tyr Gly 
            100                 105                 110         
Asp Ser Leu Ser Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        115                 120                 125             
Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser 
    130                 135                 140                 
Gly Ser Ser Gly Gly Ser Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala 
145                 150                 155                 160 
Ala Lys Gln Ile Leu 
                165 

<210> 211
<211> 176
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 211
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser 
    130                 135                 140                 
Gly Gly Ser Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg 
145                 150                 155                 160 
Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170                 175     



<210> 212
<211> 159
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 212
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser 
    130                 135                 140                 
Gly Gly Ser Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155                 

<210> 213
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 213
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp 
    130                 135                 140                 
Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155 

<210> 214
<211> 162
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb65 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 130,131
<223> Xaa can be any amino acid

<400> 214
Gly Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Leu 
1               5                   10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Thr Ala Ser Glu Ile Asp Leu Gln 
            20                  25                  30          
Tyr Tyr Pro Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              
Gly Val Ser Cys Ile Arg Ala Thr Asp Ser Gly Thr Tyr Tyr Ala Asp 
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ala Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  
Val Tyr Leu Gln Met Asn Asn Leu Ala Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      
Tyr Cys Gly Thr Asp Asp Ser Glu Asp Cys Thr Asp Tyr Ala Pro Ala 
            100                 105                 110         
His Tyr Gly Tyr Trp Gly Arg Gly Thr Gln Val Thr Val Ser Ser Ala 
        115                 120                 125             
Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser 
    130                 135                 140                 
Gly Gly Ser Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln 
145                 150                 155                 160 
Ile Leu 
        

<210> 215
<211> 169
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb14 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 215
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Gly Gly Leu 
    130                 135                 140                 
Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys Tyr Gly Pro 
145                 150                 155                 160 
Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 

<210> 216
<211> 152
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb14 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 216
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Lys Trp Phe 
    130                 135                 140                 
Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150         

<210> 217
<211> 148
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb14 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 217
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Gly Gly Gly Gly 
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala 
    130                 135                 140                 
Lys Gln Ile Leu 
145             

<210> 218
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb14 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 123,124
<223> Xaa can be any amino acid

<400> 218
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Asp Leu Ala Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Val Phe 
            20                  25                  30          
Ser Ser Tyr Ala Met Ile Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Gly Ile Asn Ser Asp Ala Ser Gly Thr Trp Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Asp Asp Thr Ala Val 
                85                  90                  95      
Tyr Phe Cys Leu His Ser Gly His Thr His Thr Arg Tyr Trp Gly Gln 
            100                 105                 110         
Gly Thr Gln Val Thr Val Ser Ser Ala Ala Xaa Xaa Ser Arg Gly Ser 
        115                 120                 125             
Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly Ile Asp Trp 
    130                 135                 140                 
Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155 

<210> 219
<211> 177
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 219
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser 
    130                 135                 140                 
Ser Gly Gly Ser Gly Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu 
145                 150                 155                 160 
Arg Ala Trp Lys Lys Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile 
                165                 170                 175     
Gly 
    

<210> 220
<211> 160
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 220
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser 
    130                 135                 140                 
Ser Gly Gly Ser Gly Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155                 160 



<210> 221
<211> 156
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 221
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp 
    130                 135                 140                 
Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155     

<210> 222
<211> 163
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAb60 linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 131,132
<223> Xaa can be any amino acid

<400> 222
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Pro Gly Leu Val Lys 
1               5                   10                  15      
Pro Ser Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile 
            20                  25                  30          
Thr Thr Thr Phe Ser His Trp Thr Trp Ile Arg Gln Ser Pro Glu Lys 
        35                  40                  45              
Gly Leu Glu Trp Met Gly Ala Ile Gly Tyr Gly Gly Ser Ile Tyr Tyr 
    50                  55                  60                  
Ser Pro Ser Phe Lys Ser Arg Thr Ser Ile Ser Arg Asp Thr Ser Arg 
65                  70                  75                  80  
Asn Gln Phe Thr Leu His Leu Ser Ser Val Thr Pro Glu Asp Thr Ala 
                85                  90                  95      
Val Tyr Tyr Cys Ala Arg Leu Pro His Ser Ser Gly Tyr Ala Lys Phe 
            100                 105                 110         
Gly His Leu Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             
Ala Ala Xaa Xaa Ser Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser 
    130                 135                 140                 
Ser Gly Gly Ser Gly Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys 
145                 150                 155                 160 
Gln Ile Leu 
            

<210> 223
<211> 172
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide BMAP28A by a SRGS linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 223
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Ser 
        115                 120                 125             
Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly 
    130                 135                 140                 
Gly Gly Leu Arg Ser Leu Gly Arg Lys Ile Leu Arg Ala Trp Lys Lys 
145                 150                 155                 160 
Tyr Gly Pro Ile Ile Val Pro Ile Ile Arg Ile Gly 
                165                 170         

<210> 224
<211> 155
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide modified cysteine deleted
      Tachyplesin-I by a SRGS linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 224
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Ser 
        115                 120                 125             
Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly 
    130                 135                 140                 
Lys Trp Phe Arg Val Tyr Arg Gly Ile Tyr Arg 
145                 150                 155 

<210> 225
<211> 151
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide Polybia-MP1 by a GS_linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 225
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Gly 
        115                 120                 125             
Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Asp Trp Lys Lys Leu Leu 
    130                 135                 140                 
Asp Ala Ala Lys Gln Ile Leu 
145                 150     

<210> 226
<211> 158
<212> PRT
<213> Artificial Sequence


<220> 
<223> sdAbS linked to the lytic peptide Polybia-MP1 by a SRGS linker

<220> 
<221> SITE
<222> 126,127
<223> Xaa can be any amino acid

<400> 226
Gly Met Ala Glu Val Glu Val Val Ala Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
            20                  25                  30          
Ser Asn Tyr Trp Met Tyr Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu 
        35                  40                  45              
Glu Trp Val Ser Ala Ile Asp Gln Ser Gly Thr Thr Thr Arg Tyr Ala 
    50                  55                  60                  
Asp Ser Val Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys His 
65                  70                  75                  80  
Thr Leu Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu 
                85                  90                  95      
Tyr Tyr Cys Thr Thr Ser Gly Arg Tyr Tyr Ala Met Asp Tyr Trp Gly 
            100                 105                 110         
Lys Gly Thr Gln Val Thr Val Ser Thr Ser Ser Ala Ala Xaa Xaa Ser 
        115                 120                 125             
Arg Gly Ser Ser Gly Ser Ser Ser Ser Gly Ser Ser Gly Gly Ser Gly 
    130                 135                 140                 
Ile Asp Trp Lys Lys Leu Leu Asp Ala Ala Lys Gln Ile Leu 
145                 150                 155             

<210> 227
<211> 4
<212> PRT
<213> Artificial Sequence


<220> 
<223> Short connecting sequence

<220> 
<221> SITE
<222> 3,4
<223> Xaa can be any amino acid

<400> 227
Ala Ala Xaa Xaa 
1               

<210> 228
<211> 15
<212> PRT
<213> Artificial Sequence


<220> 
<223> GGGGS linker

<400> 228
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  

