                         SEQUENCE LISTING

<110>  Epsilogen Ltd
 
<120>  HYBRID ANTIBODY

<130>  P6128GBWO

<150>  1914165.4
<151>  2019-10-01

<150>  1917059.6
<151>  2019-11-22

<150>  2008248.3
<151>  2020-06-02

<160>  189   

<170>  PatentIn version 3.5

<210>  1
<211>  330
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab WT IgE_VH_CH1_CH2

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
                325                 330 


<210>  2
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab WT IgE_CH3

<400>  2

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  3
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab WT IgE_CH4

<400>  3

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  4
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE Loop 1

<400>  4

Phe Asp Leu Phe Ile Arg Lys Ser 
1               5               


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE Loop 2

<400>  5

Pro Val Gly Thr Arg 
1               5   


<210>  6
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE Loop 3a

<400>  6

Ala Ser Pro Ser Gln Thr Val 
1               5           


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE Loop 3b

<400>  7

Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val 
1               5                   10              


<210>  8
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT IgG_Hinge

<400>  8

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  9
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT IgG_CH2

<400>  9

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  WT IgG_CH3

<400>  10

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG FcRn-binding Loop 1

<400>  11

Lys Asp Thr Leu Met Ile Ser Arg Thr 
1               5                   


<210>  12
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG FcRn-binding Loop 2

<400>  12

Thr Val Leu His Gln 
1               5   


<210>  13
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG FcRn-binding Loop 3A

<400>  13

Leu His Asn His Tyr Thr 
1               5       


<210>  14
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG FcRn-binding Loop 3

<400>  14

Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
1               5                   10          


<210>  15
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 1

<400>  15

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr 
        195                 200                 205             


Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 


<210>  16
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 2

<400>  16

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  17
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 3a

<400>  17

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Arg Ala Val His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215         


<210>  18
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 3b

<400>  18

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215         


<210>  19
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 1 + Loop 2

<400>  19

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr 
        195                 200                 205             


Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215                 


<210>  20
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 1 + Loop 3a

<400>  20

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Arg Ala Val His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  21
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 1 + Loop 3b

<400>  21

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  22
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 2 + Loop 3a

<400>  22

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Arg Ala Val His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215         


<210>  23
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn-binding Loop 2 + Loop 3b

<400>  23

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215         


<210>  24
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn Loop 1 + Loop 2 + Loop 3a

<400>  24

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Arg Ala Val His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  25
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 containing IgG FcRn Loop 1 + Loop 2 + Loop 3b

<400>  25

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Thr Ile Thr Cys Leu Val 
            20                  25                  30          


Val Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg 
        35                  40                  45              


Ala Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln 
    50                  55                  60                  


Arg Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His 
                85                  90                  95      


Leu Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg 
            100                 105                 110         


Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser 
        115                 120                 125             


Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu 
    130                 135                 140                 


Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala 
145                 150                 155                 160 


Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe 
                165                 170                 175     


Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp 
            180                 185                 190         


Glu Phe Ile Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  26
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH3_CH4 3His

<400>  26

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly His Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala 
            100                 105                 110         


Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg 
        115                 120                 125             


Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp 
    130                 135                 140                 


Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg 
145                 150                 155                 160 


His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val 
                165                 170                 175     


Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu 
            180                 185                 190         


Phe Ile Cys Arg Ala Val His Glu Ala Ala His Pro Ser His Thr Val 
        195                 200                 205             


Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
    210                 215             


<210>  27
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH4 plus IgG1 Hinge_CH2 (containing RS linker)

<400>  27

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys Arg Ser 
            100                 105                 110         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        115                 120                 125             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    130                 135                 140                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
145                 150                 155                 160 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                165                 170                 175     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            180                 185                 190         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
225                 230                 235         


<210>  28
<211>  344
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE_CH4 plus IgG1 Hinge_CH2_CH3 (containing RS linker)

<400>  28

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys Arg Ser 
            100                 105                 110         


Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        115                 120                 125             


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    130                 135                 140                 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
145                 150                 155                 160 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                165                 170                 175     


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            180                 185                 190         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        195                 200                 205             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    210                 215                 220                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
225                 230                 235                 240 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                245                 250                 255     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            260                 265                 270         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        275                 280                 285             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    290                 295                 300                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
305                 310                 315                 320 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                325                 330                 335     


Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 


<210>  29
<211>  675
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of the IgE plus IgG1 Hinge_CH2 construct

<400>  29

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys 
        675 


<210>  30
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of the IgE plus IgG1 Hinge_CH2_CH3 construct

<400>  30

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Cepsilon3 loop

<400>  31

Pro Val Gly His Arg 
1               5   


<210>  32
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Cepsilon4 loop sequence 1

<400>  32

Ala His Pro Ser His Thr Val 
1               5           


<210>  33
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgE Cepsilon4 loop sequence 2

<400>  33

Arg Ala Val His Glu Ala Ala His Pro Ser His Thr Val 
1               5                   10              


<210>  34
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  heavy chain of the IgE 3His construct (WT IgE_VH_CH1_CH2 plus 
       IgE_CH3_CH4 3His)

<400>  34

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly His Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala His Pro Ser His Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys 
545             


<210>  35
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  light chain of the IgE 3His construct

<400>  35

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR H1

<400>  36

Gly Phe Thr Phe Thr Asp Phe Tyr 
1               5               


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR H2

<400>  37

Ile Arg Asp Lys Ala Lys Gly Tyr Thr Thr 
1               5                   10  


<210>  38
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR H3

<400>  38

Ala Arg Glu Gly His Thr Ala Ala Pro Phe Asp Tyr 
1               5                   10          


<210>  39
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR L1

<400>  39

Gln Asn Ile Asp Lys Tyr 
1               5       


<210>  40
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR L2

<400>  40

Asn Thr Asn 
1           


<210>  41
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alemtuzumab CDR L3

<400>  41

Leu Gln His Ile Ser Arg Pro Arg Thr 
1               5                   


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR H1

<400>  42

Asp Ser Trp Ile His 
1               5   


<210>  43
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR H2

<400>  43

Trp Ile Ser Pro Tyr Gly Gly Ser Thr Tyr 
1               5                   10  


<210>  44
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR H3

<400>  44

Arg His Trp Pro Gly Gly Phe 
1               5           


<210>  45
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR L1

<400>  45

Asp Val Ser Thr Ala Val Ala 
1               5           


<210>  46
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR L2

<400>  46

Ser Ala Ser Phe Leu Tyr 
1               5       


<210>  47
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Atezolizumab CDR L3

<400>  47

Gln Gln Tyr Leu Tyr His Pro Ala Thr 
1               5                   


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR H1

<400>  48

Ser Tyr Ile Met Met 
1               5   


<210>  49
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR H2

<400>  49

Ser Ile Tyr Pro Ser Gly Gly Ile Thr Phe 
1               5                   10  


<210>  50
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR H3

<400>  50

Ile Lys Leu Phe Thr Val Thr Thr Val 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR L1

<400>  51

Val Gly Gly Tyr Asn Tyr Val Ser 
1               5               


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR L2

<400>  52

Asp Val Ser Asn Arg Pro 
1               5       


<210>  53
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Avelumab CDR L3

<400>  53

Ser Ser Tyr Thr Ser Ser Ser Thr Arg Val 
1               5                   10  


<210>  54
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR H1

<400>  54

Gly Tyr Thr Phe Thr Asn Tyr Gly 
1               5               


<210>  55
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR H2

<400>  55

Ile Asn Thr Tyr Thr Gly Glu Pro 
1               5               


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR H3

<400>  56

Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
1               5                   10                  15      


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR L1

<400>  57

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  58
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR L2

<400>  58

Phe Thr Ser 
1           


<210>  59
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bevacizumab CDR L3

<400>  59

Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210>  60
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR H2

<400>  60

Gly Trp Ile Asn Thr Tyr Ile Gly Glu Pro Ile Tyr Ala Asp Ser Val 
1               5                   10                  15      


Lys Gly 
        


<210>  61
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR H3

<400>  61

Ala Arg Gly Tyr Arg Ser Tyr Ala Met Asp Tyr 
1               5                   10      


<210>  62
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR L1

<400>  62

Lys Ala Ser Gln Asn Val Gly Thr Asn Val Ala 
1               5                   10      


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR L2

<400>  63

Ser Ala Ser Phe Leu Tyr 
1               5       


<210>  64
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR L3

<400>  64

Gln Gln Tyr Asn Ile Tyr Pro Leu 
1               5               


<210>  65
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR H1

<400>  65

Gly Phe Ser Leu Thr Asn Tyr Gly 
1               5               


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR H2

<400>  66

Ile Trp Ser Gly Gly Asn Thr 
1               5           


<210>  67
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR H3

<400>  67

Ala Arg Ala Leu Thr Tyr Tyr Asp Tyr Glu Phe Ala Tyr 
1               5                   10              


<210>  68
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR L1

<400>  68

Gln Ser Ile Gly Thr Asn 
1               5       


<210>  69
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR L2

<400>  69

Tyr Ala Ser 
1           


<210>  70
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cetuximab CDR L3

<400>  70

Gln Gln Asn Asn Asn Trp Pro Thr Thr 
1               5                   


<210>  71
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR H1

<400>  71

Arg Tyr Trp Met Ser 
1               5   


<210>  72
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR H2

<400>  72

Asn Ile Lys Gln Asp Gly Ser Glu Lys Tyr 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR H3

<400>  73

Glu Gly Gly Trp Phe Gly Glu Leu Ala Phe 
1               5                   10  


<210>  74
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR L1

<400>  74

Arg Val Ser Ser Ser Tyr Leu Ala 
1               5               


<210>  75
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR L2

<400>  75

Asp Ala Ser Ser Arg Ala 
1               5       


<210>  76
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Durvalumab CDR L3

<400>  76

Gln Gln Tyr Gly Ser Leu Pro Trp Thr 
1               5                   


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR H1

<400>  77

Gly Tyr Ser Phe Thr Gly His Trp Met Asn 
1               5                   10  


<210>  78
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR H2

<400>  78

Gly Ile Met Ile His Pro Ser Asp Ser Glu Thr Arg Tyr Asn Gln Lys 
1               5                   10                  15      


Phe Lys Asp Ile 
            20  


<210>  79
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR H3

<400>  79

Ala Arg Ile Gly Ile Tyr Phe Tyr Gly Thr Thr Tyr Phe Asp Tyr Ile 
1               5                   10                  15      


<210>  80
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR L1

<400>  80

Arg Ala Ser Lys Thr Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  81
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR L2

<400>  81

Ser Gly Ser Thr Leu Gln 
1               5       


<210>  82
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Efalizumab CDR L3

<400>  82

Gln Gln His Asn Glu Tyr Pro Leu 
1               5               


<210>  83
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR H1

<400>  83

Gly Tyr Ser Ile Thr Ser Gly Tyr Ser Trp Asn 
1               5                   10      


<210>  84
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR H2

<400>  84

Ala Ser Ile Thr Tyr Asp Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  85
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR H3

<400>  85

Ala Arg Gly Ser His Tyr Phe Gly His Trp His Phe Ala Val 
1               5                   10                  


<210>  86
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR L1

<400>  86

Arg Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Tyr Met Asn 
1               5                   10                  15  


<210>  87
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR L2

<400>  87

Ala Ala Ser Tyr Leu Glu 
1               5       


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Omalizumab CDR L3

<400>  88

Gln Gln Ser His Glu Asp Pro Tyr 
1               5               


<210>  89
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR H1

<400>  89

Gly Gly Ser Val Ser Ser Gly Asp Tyr Tyr 
1               5                   10  


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR H2

<400>  90

Ile Tyr Tyr Ser Gly Asn Thr 
1               5           


<210>  91
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR H3

<400>  91

Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile 
1               5                   10      


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR L1

<400>  92

Gln Asp Ile Ser Asn Tyr 
1               5       


<210>  93
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR L2

<400>  93

Asp Ala Ser 
1           


<210>  94
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panitumumab CDR L3

<400>  94

Gln His Phe Asp His Leu Pro Leu Ala 
1               5                   


<210>  95
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR H1

<400>  95

Gly Phe Thr Phe Thr Asp Tyr Thr 
1               5               


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR H2

<400>  96

Val Asn Pro Asn Ser Gly Gly Ser 
1               5               


<210>  97
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR H3

<400>  97

Ala Arg Asn Leu Gly Pro Ser Phe Tyr Phe Asp Tyr 
1               5                   10          


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR L1

<400>  98

Gln Asp Val Ser Ile Gly 
1               5       


<210>  99
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR L2

<400>  99

Ser Ala Ser 
1           


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Pertuzumab CDR L3

<400>  100

Gln Gln Tyr Tyr Ile Tyr Pro Tyr Thr 
1               5                   


<210>  101
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR H1

<400>  101

Gly Tyr Thr Phe Thr Ser Tyr Asn 
1               5               


<210>  102
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Certolizumab CDR H1

<400>  102

Gly Tyr Val Phe Thr Asp Tyr Gly Met Asn 
1               5                   10  


<210>  103
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR H2

<400>  103

Ile Tyr Pro Gly Asn Gly Asp Thr 
1               5               


<210>  104
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR L2

<400>  104

Ala Thr Ser 
1           


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR L3

<400>  105

Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210>  106
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR H1

<400>  106

Gly Phe Asn Ile Lys Asp Thr Tyr 
1               5               


<210>  107
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR H2

<400>  107

Ile Tyr Pro Thr Asn Gly Tyr Thr 
1               5               


<210>  108
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR H3

<400>  108

Ala Arg Ser Thr Tyr Tyr Gly Gly Asp Trp Phe Asn Val 
1               5                   10              


<210>  109
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Rituximab CDR L1

<400>  109

Ser Ser Val Ser Tyr 
1               5   


<210>  110
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR H3

<400>  110

Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr 
1               5                   10              


<210>  111
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR L1

<400>  111

Gln Asp Val Asn Thr Ala 
1               5       


<210>  112
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR L2

<400>  112

Ser Ala Ser 
1           


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab CDR L3

<400>  113

Gln Gln His Tyr Thr Thr Pro Pro Thr 
1               5                   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR H1

<400>  114

Asp Tyr Ala Met His 
1               5   


<210>  115
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR H2

<400>  115

Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val Glu 
1               5                   10                  15      


Gly 
    


<210>  116
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR H3

<400>  116

Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
1               5                   10          


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR L1

<400>  117

Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
1               5                   10      


<210>  118
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR L2

<400>  118

Ala Ala Ser Thr Leu Gln Ser 
1               5           


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Adalimumab CDR L3

<400>  119

Gln Arg Tyr Asn Arg Ala Pro Tyr Thr 
1               5                   


<210>  120
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR H1

<400>  120

Gly Tyr Ser Phe Thr Arg Tyr Trp Met His 
1               5                   10  


<210>  121
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR H2

<400>  121

Ala Ile Tyr Pro Gly Asn Ser Asp Thr Ser Tyr Asn Gln Lys Phe Glu 
1               5                   10                  15      


Gly 
    


<210>  122
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR H3

<400>  122

Asp Tyr Gly Tyr Tyr Phe Asp Phe 
1               5               


<210>  123
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR L1

<400>  123

Ser Ala Ser Ser Ser Arg Ser Tyr Met Gln 
1               5                   10  


<210>  124
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR L2

<400>  124

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  125
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Basiliximab CDR L3

<400>  125

His Gln Arg Ser Ser Tyr Thr 
1               5           


<210>  126
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR H1

<400>  126

Gly Gly Thr Phe Asn Asn Asn Ala Ile Asn 
1               5                   10  


<210>  127
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR H2

<400>  127

Gly Ile Ile Pro Met Phe Gly Thr Ala Lys Tyr Ser Gln Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR H3

<400>  128

Ser Arg Asp Leu Leu Leu Phe Pro His His Ala Leu Ser Pro 
1               5                   10                  


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR L1

<400>  129

Gln Gly Asp Ser Leu Arg Ser Tyr Tyr Ala Ser 
1               5                   10      


<210>  130
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR L2

<400>  130

Gly Lys Asn Asn Arg Pro Ser 
1               5           


<210>  131
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Belimumab CDR L3

<400>  131

Ser Ser Arg Asp Ser Ser Gly Asn His Trp Val 
1               5                   10      


<210>  132
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR H1

<400>  132

Gly Tyr Thr Phe Thr Ser Tyr Arg Met His 
1               5                   10  


<210>  133
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR H2

<400>  133

Tyr Ile Asn Pro Ser Thr Gly Tyr Thr Glu Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  134
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR H3

<400>  134

Gly Gly Gly Val Phe Asp Tyr 
1               5           


<210>  135
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR L1

<400>  135

Ser Ala Ser Ser Ser Ile Ser Tyr Met His 
1               5                   10  


<210>  136
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR L2

<400>  136

Thr Thr Ser Asn Leu Ala Ser 
1               5           


<210>  137
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Daclizumab CDR L3

<400>  137

His Gln Arg Ser Thr Tyr Pro Leu Thr 
1               5                   


<210>  138
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR H1

<400>  138

Ile Phe Ser Asn His Trp 
1               5       


<210>  139
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR H2

<400>  139

Arg Ser Lys Ser Ile Asn Ser Ala Thr His 
1               5                   10  


<210>  140
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR H3

<400>  140

Asn Tyr Tyr Gly Ser Thr Tyr 
1               5           


<210>  141
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR L1

<400>  141

Phe Val Gly Ser Ser Ile His 
1               5           


<210>  142
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR L2

<400>  142

Lys Tyr Ala Ser Glu Ser Met 
1               5           


<210>  143
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Infliximab CDR L3

<400>  143

Gln Ser His Ser Trp 
1               5   


<210>  144
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR H1

<400>  144

Gly Phe Asn Ile Lys Asp Thr Tyr Ile His 
1               5                   10  


<210>  145
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR H2

<400>  145

Arg Ile Asp Pro Ala Asn Gly Tyr Thr Lys Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR H3

<400>  146

Glu Gly Tyr Tyr Gly Asn Tyr Gly Val Tyr Ala Met Asp Tyr 
1               5                   10                  


<210>  147
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR L1

<400>  147

Lys Thr Ser Gln Asp Ile Asn Lys Tyr Met Ala 
1               5                   10      


<210>  148
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR L2

<400>  148

Tyr Thr Ser Ala Leu Gln Pro 
1               5           


<210>  149
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Natalizumab CDR L3

<400>  149

Leu Gln Tyr Asp Asn Leu Trp Thr 
1               5               


<210>  150
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR H1

<400>  150

Gly Phe Ser Leu Ser Thr Ser Gly Met Ser Val Gly 
1               5                   10          


<210>  151
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR H2

<400>  151

Asp Ile Trp Trp Asp Asp Lys Lys Asp Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  152
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR H3

<400>  152

Ser Met Ile Thr Asn Trp Tyr Phe Asp Val 
1               5                   10  


<210>  153
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR L1

<400>  153

Lys Cys Gln Leu Ser Val Gly Tyr Met His 
1               5                   10  


<210>  154
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR L2

<400>  154

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  155
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Palivizumab CDR L3

<400>  155

Phe Gln Gly Ser Gly Tyr Pro Phe Thr 
1               5                   


<210>  156
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR H1

<400>  156

Gly Tyr Asp Phe Thr His Tyr Gly Met Asn 
1               5                   10  


<210>  157
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR H2

<400>  157

Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe Lys 
1               5                   10                  15      


Arg 
    


<210>  158
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR H3

<400>  158

Tyr Pro Tyr Tyr Tyr Gly Thr Ser His Trp Phe Asp Val 
1               5                   10              


<210>  159
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR L1

<400>  159

Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn 
1               5                   10      


<210>  160
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR L2

<400>  160

Phe Thr Ser Ser Leu His Ser 
1               5           


<210>  161
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Ranibizumab CDR L3

<400>  161

Gln Gln Tyr Ser Thr Val Pro Trp Thr 
1               5                   


<210>  162
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR H1

<400>  162

Gly Phe Thr Phe Ser Asn Tyr Trp 
1               5               


<210>  163
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR H2

<400>  163

Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg 
1               5                   10  


<210>  164
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR H3

<400>  164

Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His 
1               5                   10              


<210>  165
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR L1

<400>  165

Gln Asn Val Asp Thr Asn 
1               5       


<210>  166
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR L2

<400>  166

Ser Ala Ser 
1           


<210>  167
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA CDR L3

<400>  167

Gln Gln Tyr Asn Ser Tyr Pro Leu Thr 
1               5                   


<210>  168
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA Variable Domain (Heavy Chain)

<400>  168

Glu Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser 
65                  70                  75                  80  


Ser Ala Tyr Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile 
                85                  90                  95      


Tyr Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  169
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA Variable Domain (Light Chain)

<400>  169

Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Cys 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  170
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA VH

<400>  170

Glu Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser 
65                  70                  75                  80  


Ser Ala Tyr Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile 
                85                  90                  95      


Tyr Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120             


<210>  171
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA VL

<400>  171

Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Cys 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  172
<211>  548
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE Heavy Chain

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys 
545             


<210>  173
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE-IgG-Fc Heavy Chain

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  174
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgE-IgG-Fc C220S Heavy Chain

<400>  174

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  175
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgG-IgG-Fc dFcRn Heavy Chain

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  176
<211>  782
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trastuzumab IgG-IgG-Fc dFcRn C220S Heavy Chain

<400>  176

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Tyr Pro Thr Asn Gly Tyr Thr Arg Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Trp Gly Gly Asp Gly Phe Tyr Ala Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr Ser 
    130                 135                 140                 


Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val Met 
145                 150                 155                 160 


Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu Pro 
                165                 170                 175     


Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu Leu 
            180                 185                 190         


Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val Ala 
        195                 200                 205             


His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser Val 
    210                 215                 220                 


Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser 
225                 230                 235                 240 


Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu 
                245                 250                 255     


Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp 
            260                 265                 270         


Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu 
        275                 280                 285             


Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His 
    290                 295                 300                 


Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His 
305                 310                 315                 320 


Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg Gly 
                325                 330                 335     


Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile Arg 
            340                 345                 350         


Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser Lys 
        355                 360                 365             


Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val Asn 
    370                 375                 380                 


His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr Val 
385                 390                 395                 400 


Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu Thr 
                405                 410                 415     


Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met Arg 
            420                 425                 430         


Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala 
        435                 440                 445             


Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala 
    450                 455                 460                 


Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp Leu 
465                 470                 475                 480 


His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln Pro 
                485                 490                 495     


Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu Val 
            500                 505                 510         


Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala Val 
        515                 520                 525             


His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser Val 
    530                 535                 540                 


Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr 
545                 550                 555                 560 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
                565                 570                 575     


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg Thr Pro 
            580                 585                 590         


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
        595                 600                 605             


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
    610                 615                 620                 


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
625                 630                 635                 640 


Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
                645                 650                 655     


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
            660                 665                 670         


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
        675                 680                 685             


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
    690                 695                 700                 


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
705                 710                 715                 720 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
                725                 730                 735     


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
            740                 745                 750         


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
        755                 760                 765             


Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780         


<210>  177
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Kappa Trastuzumab Light Chain

<400>  177

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Arg Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln His Tyr Thr Thr Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  178
<211>  549
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA IgE Heavy Chain

<400>  178

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Arg Tyr Tyr Ala Glu Ser 
    50                  55                  60                  


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Ala 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala Thr 
    130                 135                 140                 


Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr Leu 
                165                 170                 175     


Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser Leu 
            180                 185                 190         


Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg Val 
        195                 200                 205             


Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe Ser 
    210                 215                 220                 


Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
225                 230                 235                 240 


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
                245                 250                 255     


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
            260                 265                 270         


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
        275                 280                 285             


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
    290                 295                 300                 


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
305                 310                 315                 320 


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro Arg 
                325                 330                 335     


Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe Ile 
            340                 345                 350         


Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro Ser 
        355                 360                 365             


Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro Val 
    370                 375                 380                 


Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu Thr 
385                 390                 395                 400 


Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly Glu 
                405                 410                 415     


Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu Met 
            420                 425                 430         


Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val Tyr 
        435                 440                 445             


Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr Leu 
    450                 455                 460                 


Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln Trp 
465                 470                 475                 480 


Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr Gln 
                485                 490                 495     


Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu Glu 
            500                 505                 510         


Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg Ala 
        515                 520                 525             


Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val Ser 
    530                 535                 540                 


Val Asn Pro Gly Lys 
545                 


<210>  179
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA IgE IgG-Fc Heavy Chain

<400>  179

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala 
    130                 135                 140                 


Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr 
                165                 170                 175     


Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser 
            180                 185                 190         


Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg 
        195                 200                 205             


Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe 
    210                 215                 220                 


Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
225                 230                 235                 240 


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
                245                 250                 255     


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
            260                 265                 270         


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
        275                 280                 285             


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
    290                 295                 300                 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
305                 310                 315                 320 


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
                325                 330                 335     


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
            340                 345                 350         


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
        355                 360                 365             


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
    370                 375                 380                 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
                405                 410                 415     


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
            420                 425                 430         


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
        435                 440                 445             


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
    450                 455                 460                 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
465                 470                 475                 480 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
                485                 490                 495     


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
            500                 505                 510         


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
        515                 520                 525             


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
    530                 535                 540                 


Ser Val Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr 
545                 550                 555                 560 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                565                 570                 575     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            580                 585                 590         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        595                 600                 605             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    610                 615                 620                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                645                 650                 655     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            660                 665                 670         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        675                 680                 685             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    690                 695                 700                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
705                 710                 715                 720 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                725                 730                 735     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            740                 745                 750         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        755                 760                 765             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780                 


<210>  180
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA IgE-IgG-Fc C220S Heavy Chain

<400>  180

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala 
    130                 135                 140                 


Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr 
                165                 170                 175     


Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser 
            180                 185                 190         


Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg 
        195                 200                 205             


Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe 
    210                 215                 220                 


Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
225                 230                 235                 240 


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
                245                 250                 255     


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
            260                 265                 270         


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
        275                 280                 285             


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
    290                 295                 300                 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
305                 310                 315                 320 


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
                325                 330                 335     


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
            340                 345                 350         


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
        355                 360                 365             


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
    370                 375                 380                 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
                405                 410                 415     


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
            420                 425                 430         


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
        435                 440                 445             


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
    450                 455                 460                 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
465                 470                 475                 480 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
                485                 490                 495     


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
            500                 505                 510         


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
        515                 520                 525             


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
    530                 535                 540                 


Ser Val Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr 
545                 550                 555                 560 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                565                 570                 575     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            580                 585                 590         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        595                 600                 605             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    610                 615                 620                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                645                 650                 655     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            660                 665                 670         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        675                 680                 685             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    690                 695                 700                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
705                 710                 715                 720 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                725                 730                 735     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            740                 745                 750         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        755                 760                 765             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780                 


<210>  181
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA IgG-IgG-Fc dFcRn Heavy Chain

<400>  181

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala 
    130                 135                 140                 


Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr 
                165                 170                 175     


Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser 
            180                 185                 190         


Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg 
        195                 200                 205             


Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe 
    210                 215                 220                 


Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
225                 230                 235                 240 


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
                245                 250                 255     


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
            260                 265                 270         


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
        275                 280                 285             


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
    290                 295                 300                 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
305                 310                 315                 320 


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
                325                 330                 335     


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
            340                 345                 350         


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
        355                 360                 365             


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
    370                 375                 380                 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
                405                 410                 415     


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
            420                 425                 430         


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
        435                 440                 445             


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
    450                 455                 460                 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
465                 470                 475                 480 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
                485                 490                 495     


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
            500                 505                 510         


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
        515                 520                 525             


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
    530                 535                 540                 


Ser Val Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Cys Asp Lys Thr 
545                 550                 555                 560 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                565                 570                 575     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg 
            580                 585                 590         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        595                 600                 605             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    610                 615                 620                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                645                 650                 655     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            660                 665                 670         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        675                 680                 685             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    690                 695                 700                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
705                 710                 715                 720 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                725                 730                 735     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            740                 745                 750         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        755                 760                 765             


Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780                 


<210>  182
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA IgG-IgG-Fc dFcRn C220S Heavy ChaiN

<400>  182

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala 
    130                 135                 140                 


Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr 
                165                 170                 175     


Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser 
            180                 185                 190         


Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg 
        195                 200                 205             


Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe 
    210                 215                 220                 


Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
225                 230                 235                 240 


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
                245                 250                 255     


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
            260                 265                 270         


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
        275                 280                 285             


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
    290                 295                 300                 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
305                 310                 315                 320 


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
                325                 330                 335     


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
            340                 345                 350         


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
        355                 360                 365             


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
    370                 375                 380                 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp Trp Ile Glu Gly 
                405                 410                 415     


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
            420                 425                 430         


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
        435                 440                 445             


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
    450                 455                 460                 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
465                 470                 475                 480 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
                485                 490                 495     


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
            500                 505                 510         


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
        515                 520                 525             


Ala Val His Glu Ala Ala Ser Pro Ser Gln Thr Val Gln Arg Ala Val 
    530                 535                 540                 


Ser Val Asn Pro Gly Lys Arg Ser Glu Pro Lys Ser Ser Asp Lys Thr 
545                 550                 555                 560 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                565                 570                 575     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ala Ser Arg 
            580                 585                 590         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        595                 600                 605             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    610                 615                 620                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Val Leu Ala Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                645                 650                 655     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            660                 665                 670         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        675                 680                 685             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    690                 695                 700                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
705                 710                 715                 720 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                725                 730                 735     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            740                 745                 750         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        755                 760                 765             


Leu His Asn Ala Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780                 


<210>  183
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA Kappa Light Chain

<400>  183

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  184
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA Alternative Variable Domain (Heavy Chain)

<400>  184

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  185
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA Alternative Variable Domain (Light Chain)

<400>  185

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  186
<211>  551
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA heavy chain with 3 His mutation

<400>  186

Glu Gln Val Lys Leu Gln Gln Ser Gly Gly Gly Leu Val Gln Pro Gly 
1               5                   10                  15      


Gly Ser Met Lys Leu Ser Cys Val Val Ser Gly Phe Thr Phe Ser Asn 
            20                  25                  30          


Tyr Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp 
        35                  40                  45              


Ile Ala Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala 
    50                  55                  60                  


Glu Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser 
65                  70                  75                  80  


Ser Ala Tyr Leu Gln Met Ile Asn Leu Arg Ala Glu Asp Thr Gly Ile 
                85                  90                  95      


Tyr Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His 
            100                 105                 110         


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Gln Ser 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn 
    130                 135                 140                 


Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu 
145                 150                 155                 160 


Pro Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met 
                165                 170                 175     


Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile 
            180                 185                 190         


Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys 
        195                 200                 205             


Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr 
    210                 215                 220                 


Phe Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu 
225                 230                 235                 240 


Gln Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu 
                245                 250                 255     


Leu Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp 
            260                 265                 270         


Leu Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr 
        275                 280                 285             


Thr Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser 
    290                 295                 300                 


Gln Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr 
305                 310                 315                 320 


Gln Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn 
                325                 330                 335     


Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu 
            340                 345                 350         


Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala 
        355                 360                 365             


Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys 
    370                 375                 380                 


Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr 
385                 390                 395                 400 


Leu Thr Val Thr Ser Thr Leu Pro Val Gly His Arg Asp Trp Ile Glu 
                405                 410                 415     


Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala 
            420                 425                 430         


Leu Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu 
        435                 440                 445             


Val Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg 
    450                 455                 460                 


Thr Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val 
465                 470                 475                 480 


Gln Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr 
                485                 490                 495     


Thr Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg 
            500                 505                 510         


Leu Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys 
        515                 520                 525             


Arg Ala Val His Glu Ala Ala His Pro Ser His Thr Val Gln Arg Ala 
    530                 535                 540                 


Val Ser Val Asn Pro Gly Lys 
545                 550     


<210>  187
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HMW-MAA light chain

<400>  187

Asp Ile Glu Leu Thr Gln Ser Pro Lys Phe Met Ser Thr Ser Val Cys 
1               5                   10                  15      


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Glu Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Gly Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  188
<211>  550
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative HMW-MAA heavy chain with 3His mutation

<400>  188

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Val Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Glu Ile Arg Leu Lys Ser Asn Asn Phe Gly Arg Tyr Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr 
65                  70                  75                  80  


Ala Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Thr Ser Tyr Gly Asn Tyr Val Gly His Tyr Phe Asp His Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Gln Ser Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Thr Arg Cys Cys Lys Asn Ile Pro Ser Asn Ala 
    130                 135                 140                 


Thr Ser Val Thr Leu Gly Cys Leu Ala Thr Gly Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Met Val Thr Trp Asp Thr Gly Ser Leu Asn Gly Thr Thr Met Thr 
                165                 170                 175     


Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly His Tyr Ala Thr Ile Ser 
            180                 185                 190         


Leu Leu Thr Val Ser Gly Ala Trp Ala Lys Gln Met Phe Thr Cys Arg 
        195                 200                 205             


Val Ala His Thr Pro Ser Ser Thr Asp Trp Val Asp Asn Lys Thr Phe 
    210                 215                 220                 


Ser Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln 
225                 230                 235                 240 


Ser Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu 
                245                 250                 255     


Cys Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu 
            260                 265                 270         


Glu Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr 
        275                 280                 285             


Gln Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln 
    290                 295                 300                 


Lys His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln 
305                 310                 315                 320 


Gly His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala Asp Ser Asn Pro 
                325                 330                 335     


Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro Phe Asp Leu Phe 
            340                 345                 350         


Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val Asp Leu Ala Pro 
        355                 360                 365             


Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala Ser Gly Lys Pro 
    370                 375                 380                 


Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg Asn Gly Thr Leu 
385                 390                 395                 400 


Thr Val Thr Ser Thr Leu Pro Val Gly His Arg Asp Trp Ile Glu Gly 
                405                 410                 415     


Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu Pro Arg Ala Leu 
            420                 425                 430         


Met Arg Ser Thr Thr Lys Thr Ser Gly Pro Arg Ala Ala Pro Glu Val 
        435                 440                 445             


Tyr Ala Phe Ala Thr Pro Glu Trp Pro Gly Ser Arg Asp Lys Arg Thr 
    450                 455                 460                 


Leu Ala Cys Leu Ile Gln Asn Phe Met Pro Glu Asp Ile Ser Val Gln 
465                 470                 475                 480 


Trp Leu His Asn Glu Val Gln Leu Pro Asp Ala Arg His Ser Thr Thr 
                485                 490                 495     


Gln Pro Arg Lys Thr Lys Gly Ser Gly Phe Phe Val Phe Ser Arg Leu 
            500                 505                 510         


Glu Val Thr Arg Ala Glu Trp Glu Gln Lys Asp Glu Phe Ile Cys Arg 
        515                 520                 525             


Ala Val His Glu Ala Ala His Pro Ser His Thr Val Gln Arg Ala Val 
    530                 535                 540                 


Ser Val Asn Pro Gly Lys 
545                 550 


<210>  189
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Alternative HMW-MAA light chain

<400>  189

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Asp Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Leu 
        35                  40                  45              


Phe Ser Ala Ser Tyr Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Gly Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


