               SEQUENCE LISTING

<110> Bayer AG
      Bayer Pharma Aktiengesellschaft

<120> Substituted pyrazolopyrimidines as IRAK4 inhibitors

<130> BHC193003 EP

<160> 1

<170> BiSSAP 1.3.6

<210> 1
<211> 497
<212> PRT
<213> Artificial Sequence


<220> 
<223> His-tagged IRAK4 of dog

<400> 1
Met Thr Ser His His His His His His Ser Ser Met Gly Ser Arg Thr 
1               5                   10                  15      
Ser Leu Tyr Lys Lys Ala Gly Phe Asp Tyr Asp Ile Pro Thr Thr Glu 
            20                  25                  30          
Asn Leu Tyr Phe Gln Gly Asn Lys Pro Ile Thr Ser Ser Thr Tyr Val 
        35                  40                  45              
Arg Cys Leu Asn Leu Gly Leu Ile Arg Lys Leu Ser Asp Phe Ile Asp 
    50                  55                  60                  
Pro Gln Glu Gly Trp Lys Lys Leu Ala Val Ala Ile Lys Lys Pro Ser 
65                  70                  75                  80  
Gly Asp Asp Arg Tyr Asn Gln Phe His Ile Arg Arg Phe Glu Ala Leu 
                85                  90                  95      
Leu Gln Thr Gly Lys Ser Pro Thr Cys Glu Leu Leu Phe Asp Trp Gly 
            100                 105                 110         
Thr Thr Asn Cys Thr Val Gly Asp Leu Val Asp Leu Leu Ile Gln Asn 
        115                 120                 125             
Glu Phe Phe Ala Pro Ala Ser Leu Leu Leu Pro Asp Ala Ile Pro Lys 
    130                 135                 140                 
Thr Pro Asn Thr Val Pro Ser Glu Glu Ala Val Thr Val Gln Gln Gln 
145                 150                 155                 160 
Gln Met Pro Leu Asn Gly Lys Asp Arg Thr Phe Val Leu Pro Val Gln 
                165                 170                 175     
Asn Phe Glu Gln Asn Tyr Met Pro Pro Asp Ser Ser Ser Pro Glu Asn 
            180                 185                 190         
Thr Ser Leu Glu Gly Ser Asp Thr Arg Phe His Ser Phe Ser Phe Tyr 
        195                 200                 205             
Glu Leu Lys Asn Val Thr Asn Asn Phe Asp Glu Arg Pro Ile Ser Leu 
    210                 215                 220                 
Gly Gly Asn Lys Met Gly Glu Gly Gly Phe Gly Val Val Tyr Lys Gly 
225                 230                 235                 240 
Tyr Val Asn Asn Lys Thr Val Ala Val Lys Lys Leu Ala Ala Met Val 
                245                 250                 255     
Asp Ile Ser Thr Glu Glu Leu Lys Gln Gln Phe Asp Gln Glu Ile Lys 
            260                 265                 270         
Val Met Ala Lys Cys Gln His Glu Asn Leu Val Glu Leu Leu Gly Phe 
        275                 280                 285             
Ser Ser Asp Gly Asp Asp Leu Cys Leu Val Tyr Val Tyr Met Pro Asn 
    290                 295                 300                 
Gly Ser Leu Leu Asp Arg Leu Ser Cys Leu Asp Gly Thr Pro Pro Leu 
305                 310                 315                 320 
Ser Trp His Met Arg Cys Lys Ile Ala Gln Gly Ala Ala Asn Gly Ile 
                325                 330                 335     
Ser Phe Leu His Glu Asn His His Ile His Arg Asp Ile Lys Ser Ala 
            340                 345                 350         
Asn Ile Leu Leu Asp Glu Asp Phe Thr Ala Lys Val Ser Asp Phe Gly 
        355                 360                 365             
Leu Ala Arg Ala Ser Glu Lys Phe Ala Gln Thr Val Met Thr Ser Arg 
    370                 375                 380                 
Ile Val Gly Thr Thr Ala Tyr Met Ala Pro Glu Ala Leu Arg Gly Glu 
385                 390                 395                 400 
Ile Thr Pro Lys Ser Asp Ile Tyr Ser Phe Gly Val Val Leu Leu Glu 
                405                 410                 415     
Ile Ile Thr Gly Leu Pro Ala Val Asp Glu His Arg Glu Pro Gln Leu 
            420                 425                 430         
Leu Leu Asp Ile Lys Glu Glu Ile Glu Asp Glu Glu Lys Thr Ile Glu 
        435                 440                 445             
Asp Tyr Ile Asp Pro Lys Met Asn Asp Thr Asp Pro Thr Ser Ile Glu 
    450                 455                 460                 
Thr Met Tyr Ser Val Ala Ser Gln Cys Leu His Glu Lys Lys Asn Lys 
465                 470                 475                 480 
Arg Pro Asp Ile Glu Lys Val Gln Gln Leu Leu Gln Asp Leu Thr Ala 
                485                 490                 495     
Ser 
    

