                         SEQUENCE LISTING

<110>  Beijing StarMab BioMed Technology Ltd.
 
<120>  Monospecific and Multispecific Antibodies

<130>  1959708-00002

<150>  US62/907,275
<151>  2019-09-27

<150>  US62/989,327
<151>  2020-03-13

<160>  225   

<170>  PatentIn version 3.5

<210>  1
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  1

Gln Leu Leu Phe Asn Lys Thr Lys Ser Val Glu Phe Thr Phe Cys Asn 
1               5                   10                  15      


Asp Thr Val Val Ile Pro Cys Phe Val Thr Asn Met Glu Ala Gln Asn 
            20                  25                  30          


Thr Thr Glu Val Tyr Val Lys Trp Lys Phe Lys Gly Arg Asp Ile Tyr 
        35                  40                  45              


Thr Phe Asp Gly Ala Leu Asn Lys Ser Thr Val Pro Thr Asp Phe Ser 
    50                  55                  60                  


Ser Ala Lys Ile Glu Val Ser Gln Leu Leu Lys Gly Asp Ala Ser Leu 
65                  70                  75                  80  


Lys Met Asp Lys Ser Asp Ala Val Ser His Thr Gly Asn Tyr Thr Cys 
                85                  90                  95      


Glu Val Thr Glu Leu Thr Arg Glu Gly Glu Thr Ile Ile Glu Leu Lys 
            100                 105                 110         


Tyr Arg Val Val Ser Trp Phe Ser Pro 
        115                 120     


<210>  2
<211>  127
<212>  PRT
<213>  Lama glama

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Gly Val Asn Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn 
            100                 105                 110         


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  3
<211>  127
<212>  PRT
<213>  Lama glama

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Gly Val Asn Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ala Thr Ala Ile Lys 
            100                 105                 110         


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  4
<211>  127
<212>  PRT
<213>  Lama glama

<400>  4

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Gly Val Asn Ser Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Phe Ala Ser Lys 
            100                 105                 110         


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  5
<211>  127
<212>  PRT
<213>  Lama glama

<400>  5

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Val Met Trp Ser Ser 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn 
            100                 105                 110         


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  6
<211>  127
<212>  PRT
<213>  Lama glama

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ile Arg Phe Phe Gly Ser 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn 
            100                 105                 110         


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  7
<211>  129
<212>  PRT
<213>  Lama glama

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  8
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized VHH A09-10

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  9
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-1

<400>  9

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  10
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-2

<400>  10

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  11
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-3

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  12
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-04

<400>  12

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  13
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-45

<400>  13

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  14
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-5

<400>  14

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  15
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-55

<400>  15

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val 
    130                 135                 140                 


Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  16
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-6

<400>  16

Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
1               5                   10                  15      


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
            20                  25                  30          


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Asp 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
65                  70                  75                  80  


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
            100                 105                 110         


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        115                 120                 125             


Thr Val Ser Ser 
    130         


<210>  17
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-66

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  18
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-7

<400>  18

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  19
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-77

<400>  19

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  20
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-8

<400>  20

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  21
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-88

<400>  21

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  22
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-9

<400>  22

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  23
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-99

<400>  23

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  24
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-10

<400>  24

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  25
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  bivalent humanized hA09-10-100

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     


<210>  26
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-11

<400>  26

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  27
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-12

<400>  27

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  28
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-13

<400>  28

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  29
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-14

<400>  29

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ser Ala Ile Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  30
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Thr Val Thr Val Pro Lys Asp Leu Tyr Val Val Glu Tyr Gly Ser 
1               5                   10                  15      


Asn Met Thr Ile Glu Cys Lys Phe Pro Val Glu Lys Gln Leu Asp Leu 
            20                  25                  30          


Ala Ala Leu Ile Val Tyr Trp Glu Met Glu Asp Lys Asn Ile Ile Gln 
        35                  40                  45              


Phe Val His Gly Glu Glu Asp Leu Lys Val Gln His Ser Ser Tyr Arg 
    50                  55                  60                  


Gln Arg Ala Arg Leu Leu Lys Asp Gln Leu Ser Leu Gly Asn Ala Ala 
65                  70                  75                  80  


Leu Gln Ile Thr Asp Val Lys Leu Gln Asp Ala Gly Val Tyr Arg Cys 
                85                  90                  95      


Met Ile Ser Tyr Gly Gly Ala Asp Tyr Lys Arg Ile Thr Val Lys Val 
            100                 105                 110         


Asn Ala Pro Tyr Asn Lys Ile Asn Gln Arg Ile Leu Val Val Asp Pro 
        115                 120                 125             


Val Thr Ser Glu His Glu Leu Thr Cys Gln Ala Glu Gly Tyr Pro Lys 
    130                 135                 140                 


Ala Glu Val Ile Trp Thr Ser Ser Asp His Gln Val Leu Ser Gly Lys 
145                 150                 155                 160 


Thr Thr Thr Thr Asn Ser Lys Arg Glu Glu Lys Leu Phe Asn Val Thr 
                165                 170                 175     


Ser Thr Leu Arg Ile Asn Thr Thr Thr Asn Glu Ile Phe Tyr Cys Thr 
            180                 185                 190         


Phe Arg Arg Leu Asp Pro Glu Glu Asn His Thr Ala Glu Leu Val Ile 
        195                 200                 205             


Pro Glu Leu Pro Leu Ala His Pro Pro Asn Glu Arg 
    210                 215                 220 


<210>  31
<211>  127
<212>  PRT
<213>  Lama glama

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Leu Thr Leu Ser Arg Tyr 
            20                  25                  30          


Thr Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Ile Ile Arg Asn Ser Val Ser Thr Phe His Glu Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Val Lys Asn Met Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asn Val Gly Pro Thr Gly Gly Phe Ser Leu Gln Ser Val Gln 
            100                 105                 110         


Arg Tyr Asp Ala Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  32
<211>  123
<212>  PRT
<213>  Lama glama

<400>  32

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asp Trp Tyr Thr Thr Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Arg Ser Thr Ala Thr Ile Thr Gly Gln Ala Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
        115                 120             


<210>  33
<211>  114
<212>  PRT
<213>  Lama glama

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ser Gly Ile Tyr 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Val Val 
        35                  40                  45              


Gly Ile Ile Thr Ser Gly Gly Thr Thr Asn Tyr Ala Asp Phe Ala Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Met Met Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ile Arg Thr Arg Leu Ile Ile Trp Gly Gln Gly Thr Gln Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  34
<211>  124
<212>  PRT
<213>  Lama glama

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Phe Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Leu Gly Trp Phe Arg Gln Gly Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Asn Trp Ser Gly Tyr Met Thr Ser Tyr Val Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Ala Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  35
<211>  123
<212>  PRT
<213>  Lama glama

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Thr Tyr 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Arg Thr Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Met Asp Trp Asn Thr Ile Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Arg Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ile Arg Ser Thr Ala Ile Ile Thr Gly Gln Ala Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  36
<211>  127
<212>  PRT
<213>  Lama glama

<400>  36

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ser Met Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Val Arg Ile Asn Trp Asn Arg Gly Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Asn Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Arg Gly Ser Pro Ser Thr Ile Gly Ala Phe Thr Ser Ala Ser 
            100                 105                 110         


His Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125         


<210>  37
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized PL14

<400>  37

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ser Gly Ile Tyr 
            20                  25                  30          


Asp Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Leu Arg Glu Val Val 
        35                  40                  45              


Ser Val Ile Thr Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Ile Arg Thr Arg Leu Ile Ile Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  38
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized PL16

<400>  38

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  39
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala 
1               5                   10                  15      


Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 
            20                  25                  30          


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
        35                  40                  45              


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 
    50                  55                  60                  


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
65                  70                  75                  80  


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
                85                  90                  95      


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
            100                 105                 110         


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
        115                 120                 125             


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
    130                 135                 140                 


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
145                 150                 155                 160 


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
                165                 170                 175     


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
            180                 185                 190         


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
        195                 200                 205             


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
    210                 215                 220                 


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
225                 230                 235                 240 


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
                245                 250                 255     


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
            260                 265                 270         


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
        275                 280                 285             


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
    290                 295                 300                 


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
305                 310                 315                 320 


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
                325                 330                 335     


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
            340                 345                 350         


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
        355                 360                 365             


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
    370                 375                 380                 


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
385                 390                 395                 400 


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
                405                 410                 415     


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
            420                 425                 430         


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
        435                 440                 445             


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
    450                 455                 460                 


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
465                 470                 475                 480 


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
                485                 490                 495     


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
            500                 505                 510         


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
        515                 520                 525             


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
    530                 535                 540                 


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
545                 550                 555                 560 


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
                565                 570                 575     


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
            580                 585                 590         


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
        595                 600                 605             


Leu 
    


<210>  40
<211>  122
<212>  PRT
<213>  Lama glama

<400>  40

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ala Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Arg Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Ser Leu Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Glu Ser Ser Ser Arg Gln Asp Lys Trp Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  41
<211>  123
<212>  PRT
<213>  Lama glama

<400>  41

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Thr Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  42
<211>  123
<212>  PRT
<213>  Lama glama

<400>  42

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Ile Phe His Thr Tyr 
            20                  25                  30          


Ala Val Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Val Ile Ile Asn Trp Ser Ser Asp His Thr Tyr Val Ala Gln Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Arg Ala Lys Asn Thr Phe Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Val Arg Arg Arg Leu Tyr Gly Leu Arg Glu Ser Asp Phe Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  43
<211>  124
<212>  PRT
<213>  Lama glama

<400>  43

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ile Ser Phe 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ser Ile Thr Asn Ser Gly Ser Gly Ile Leu Tyr Gly Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Met Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Thr Gly Ala Gly Arg Tyr Arg Tyr Ala Ser Met Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  44
<211>  128
<212>  PRT
<213>  Lama glama

<400>  44

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Pro Thr Phe Ser Asn Tyr 
            20                  25                  30          


Phe Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Lys Trp Ser Gly Tyr His Thr Tyr Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Gln Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Gly Thr Phe Ser Asn Trp Tyr Thr Arg Pro Arg Ser Gly 
            100                 105                 110         


Asp Ser Tyr Asp His Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  45
<211>  124
<212>  PRT
<213>  Lama glama

<400>  45

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Ser Pro Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Ser Gly Lys Glu Arg Glu Ser Val 
        35                  40                  45              


Ala Ala Thr Thr Trp Thr Gly Ser Arg Ser Tyr Tyr Gly Glu Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Ser Thr Lys Asn Thr Met Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Asp Gly Ala Gly Leu Tyr Thr Asn Arg Gly Gln Tyr Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 


<210>  46
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hHS5

<400>  46

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  47
<211>  125
<212>  PRT
<213>  Lama glama

<400>  47

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  48
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hHS10

<400>  48

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  49
<211>  242
<212>  PRT
<213>  Homo sapiens

<400>  49

Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln Glu 
1               5                   10                  15      


Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro Tyr 
            20                  25                  30          


Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala 
        35                  40                  45              


Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu 
    50                  55                  60                  


Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser 
65                  70                  75                  80  


Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn 
                85                  90                  95      


Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr 
            100                 105                 110         


Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro 
        115                 120                 125             


Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu 
    130                 135                 140                 


Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe 
145                 150                 155                 160 


Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His 
                165                 170                 175     


Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn 
            180                 185                 190         


Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg 
        195                 200                 205             


Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly 
    210                 215                 220                 


Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val 
225                 230                 235                 240 


Val His 
        


<210>  50
<211>  123
<212>  PRT
<213>  Lama glama

<400>  50

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Leu Lys Gly Ala Ser Trp Tyr Ser Ala Asn Tyr Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  51
<211>  111
<212>  PRT
<213>  Lama glama

<400>  51

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Thr Ala Ser Ala Asn Ile Leu Arg Thr Ala 
            20                  25                  30          


Pro Met Ala Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Phe Val 
        35                  40                  45              


Ala Leu Ile Thr Ala Asp Gly Thr Thr Asp Tyr Gln Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Thr Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Gln Ser Glu Asp Thr Ala Arg Tyr Phe Cys Lys 
                85                  90                  95      


Val Tyr Ser Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            100                 105                 110     


<210>  52
<211>  118
<212>  PRT
<213>  Lama glama

<400>  52

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Glu Ala Ser Gly Ser Ile Phe Ser Ile Ala 
            20                  25                  30          


His Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Val Ile Ser Ser Gly Gly Arg Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Phe Cys Asn 
                85                  90                  95      


Val Ala Val Val Gly Gly Pro Arg Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  53
<211>  119
<212>  PRT
<213>  Lama glama

<400>  53

Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Val Ser Thr Tyr 
            20                  25                  30          


Val Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Glu Ile Asn Arg Ile Gly Asp Thr Leu Tyr Asn Arg Thr Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Ser Cys 
                85                  90                  95      


Ala Ala Arg Val Ile Gly Thr Ser Thr Tyr Asn Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  121
<212>  PRT
<213>  Lama glama

<400>  54

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Ile Ser Ser Ile Asn 
            20                  25                  30          


Ser Met Asn Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Lys Val 
        35                  40                  45              


Ala Gly Ile Asn Ser Ser Gly Asp Thr Asn Tyr Val Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Glu Arg Thr Thr Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Asn Leu Lys Pro Glu Asp Thr Gly Leu Tyr Tyr Cys Asn 
                85                  90                  95      


Ala Asp Pro Arg Pro Trp Pro Asn Asp Val Ala Phe Gly Ser Trp Gly 
            100                 105                 110         


Gln Gly Thr Arg Val Thr Val Ser Ser 
        115                 120     


<210>  55
<211>  117
<212>  PRT
<213>  Lama glama

<400>  55

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Asp 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Lys Asp Asn Thr Lys Asn Met Val Tyr 
65                  70                  75                  80  


Leu Arg Met Asp Asn Leu Gly Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  56
<211>  123
<212>  PRT
<213>  Lama glama

<400>  56

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Leu Ala Ser Gly Arg Thr Ser Ser Asn Ser 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Gly Ala Ile Thr Trp Asn Gly Asp Thr Thr Leu Tyr Ala Tyr Tyr Val 
    50                  55                  60                  


Lys Asp Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Met Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Thr Asp Lys Phe Ala Ser Ser Gln Ala Asp Ser Tyr Thr Thr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  57
<211>  123
<212>  PRT
<213>  Lama glama

<400>  57

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Phe Ser Gly Ala Ser Trp Tyr Ser Ala Gln Tyr His Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  58
<211>  123
<212>  PRT
<213>  Lama glama

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Phe Asn Gly Ala Ser Trp Phe Ala Ala Asn Tyr His Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  123
<212>  PRT
<213>  Lama glama

<400>  59

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Leu Lys Gly Ala Ser Trp Phe Ala Ser His Tyr Lys Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  60
<211>  123
<212>  PRT
<213>  Lama glama

<400>  60

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ile Asn Ala Ala Ser Trp Phe Ala Ala Lys Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  123
<212>  PRT
<213>  Lama glama

<400>  61

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Arg Gly Ser Ser Trp Phe Ser Ser His Tyr Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  62
<211>  123
<212>  PRT
<213>  Lama glama

<400>  62

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Leu Ser Gly Ala Ser Trp Phe Ala Ser Gln Tyr Glu Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  63
<211>  123
<212>  PRT
<213>  Lama glama

<400>  63

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Lys Gly Ala Ser Trp Phe Ser Ala Asn Tyr Gln Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  64
<211>  123
<212>  PRT
<213>  Lama glama

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Phe Lys Gly Ala Ser Trp Phe Ala Ser His Tyr Gln Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  65
<211>  123
<212>  PRT
<213>  Lama glama

<400>  65

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Phe Asn Gly Ala Ser Trp Phe Ser Ser Asn Tyr Glu Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  66
<211>  123
<212>  PRT
<213>  Lama glama

<400>  66

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ile Arg Gly Ser Ser Trp Phe Ala Thr His Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  67
<211>  123
<212>  PRT
<213>  Lama glama

<400>  67

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Leu Arg Gly Ala Ser Trp Phe Ala Ala Asn Tyr Lys Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  68
<211>  123
<212>  PRT
<213>  Lama glama

<400>  68

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Leu Arg Gly Ala Ser Trp Phe Ala Ala Asn Tyr Asp Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  69
<211>  123
<212>  PRT
<213>  Lama glama

<400>  69

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ile Ser Ala Ala Ser Trp Tyr Ala Ser Gln Tyr Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  70
<211>  123
<212>  PRT
<213>  Lama glama

<400>  70

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Ser Gly Ala Ser Trp Tyr Ala Ser His Tyr Glu Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  71
<211>  123
<212>  PRT
<213>  Lama glama

<400>  71

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Ser Glu Ala Ser Trp Phe Ala Ser Lys Tyr Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  72
<211>  123
<212>  PRT
<213>  Lama glama

<400>  72

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Ile Ser Gly Ala Ser Trp Phe Ala Ala His Tyr Lys Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  73
<211>  123
<212>  PRT
<213>  Lama glama

<400>  73

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Phe Arg Gly Ala Ser Trp Phe Ser Ser His Tyr Asn Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  74
<211>  123
<212>  PRT
<213>  Lama glama

<400>  74

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Lys Gly Ala Ser Trp Phe Ser Ser Asn Tyr Lys Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  75
<211>  123
<212>  PRT
<213>  Lama glama

<400>  75

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Ile Lys Ala Ser Ser Trp Tyr Ser Ser His Tyr Asn Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  76
<211>  123
<212>  PRT
<213>  Lama glama

<400>  76

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asn Val Arg Gly Ala Ser Trp Phe Ala Ala His Tyr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  77
<211>  123
<212>  PRT
<213>  Lama glama

<400>  77

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Glu Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Gly Ile Asn Asn Asn Gly Asp Thr Leu Tyr Asn Thr Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu His Met Asn Ser Leu Lys Leu Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Lys Val Arg Ala Ala Ser Trp Phe Ala Ala Gln Tyr Lys Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120             


<210>  78
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized h33-14

<400>  78

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  79
<211>  422
<212>  PRT
<213>  Homo sapiens

<400>  79

Val Pro Val Val Trp Ala Gln Glu Gly Ala Pro Ala Gln Leu Pro Cys 
1               5                   10                  15      


Ser Pro Thr Ile Pro Leu Gln Asp Leu Ser Leu Leu Arg Arg Ala Gly 
            20                  25                  30          


Val Thr Trp Gln His Gln Pro Asp Ser Gly Pro Pro Ala Ala Ala Pro 
        35                  40                  45              


Gly His Pro Leu Ala Pro Gly Pro His Pro Ala Ala Pro Ser Ser Trp 
    50                  55                  60                  


Gly Pro Arg Pro Arg Arg Tyr Thr Val Leu Ser Val Gly Pro Gly Gly 
65                  70                  75                  80  


Leu Arg Ser Gly Arg Leu Pro Leu Gln Pro Arg Val Gln Leu Asp Glu 
                85                  90                  95      


Arg Gly Arg Gln Arg Gly Asp Phe Ser Leu Trp Leu Arg Pro Ala Arg 
            100                 105                 110         


Arg Ala Asp Ala Gly Glu Tyr Arg Ala Ala Val His Leu Arg Asp Arg 
        115                 120                 125             


Ala Leu Ser Cys Arg Leu Arg Leu Arg Leu Gly Gln Ala Ser Met Thr 
    130                 135                 140                 


Ala Ser Pro Pro Gly Ser Leu Arg Ala Ser Asp Trp Val Ile Leu Asn 
145                 150                 155                 160 


Cys Ser Phe Ser Arg Pro Asp Arg Pro Ala Ser Val His Trp Phe Arg 
                165                 170                 175     


Asn Arg Gly Gln Gly Arg Val Pro Val Arg Glu Ser Pro His His His 
            180                 185                 190         


Leu Ala Glu Ser Phe Leu Phe Leu Pro Gln Val Ser Pro Met Asp Ser 
        195                 200                 205             


Gly Pro Trp Gly Cys Ile Leu Thr Tyr Arg Asp Gly Phe Asn Val Ser 
    210                 215                 220                 


Ile Met Tyr Asn Leu Thr Val Leu Gly Leu Glu Pro Pro Thr Pro Leu 
225                 230                 235                 240 


Thr Val Tyr Ala Gly Ala Gly Ser Arg Val Gly Leu Pro Cys Arg Leu 
                245                 250                 255     


Pro Ala Gly Val Gly Thr Arg Ser Phe Leu Thr Ala Lys Trp Thr Pro 
            260                 265                 270         


Pro Gly Gly Gly Pro Asp Leu Leu Val Thr Gly Asp Asn Gly Asp Phe 
        275                 280                 285             


Thr Leu Arg Leu Glu Asp Val Ser Gln Ala Gln Ala Gly Thr Tyr Thr 
    290                 295                 300                 


Cys His Ile His Leu Gln Glu Gln Gln Leu Asn Ala Thr Val Thr Leu 
305                 310                 315                 320 


Ala Ile Ile Thr Val Thr Pro Lys Ser Phe Gly Ser Pro Gly Ser Leu 
                325                 330                 335     


Gly Lys Leu Leu Cys Glu Val Thr Pro Val Ser Gly Gln Glu Arg Phe 
            340                 345                 350         


Val Trp Ser Ser Leu Asp Thr Pro Ser Gln Arg Ser Phe Ser Gly Pro 
        355                 360                 365             


Trp Leu Glu Ala Gln Glu Ala Gln Leu Leu Ser Gln Pro Trp Gln Cys 
    370                 375                 380                 


Gln Leu Tyr Gln Gly Glu Arg Leu Leu Gly Ala Ala Val Tyr Phe Thr 
385                 390                 395                 400 


Glu Leu Ser Ser Pro Gly Ala Gln Arg Ser Gly Arg Ala Pro Gly Ala 
                405                 410                 415     


Leu Pro Ala Gly His Leu 
            420         


<210>  80
<211>  121
<212>  PRT
<213>  Lama glama

<400>  80

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Thr Ile Phe Ser Ile Asn 
            20                  25                  30          


Ala Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ile Val Thr Phe Gly Gly Ser Thr Asn Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Ala Arg Asn Val Gln Ser Pro Val Gln Tyr His Leu Ala Val Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  81
<211>  118
<212>  PRT
<213>  Lama glama

<400>  81

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Ile Phe Ser Ile Ser 
            20                  25                  30          


Thr Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ser Ile Thr Ala Arg Gly Ser Ala Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Thr Asp Thr Arg Ser Thr Leu Tyr His Tyr Ser Trp Gly Gln Gly Thr 
            100                 105                 110         


Gln Val Thr Val Ser Ser 
        115             


<210>  82
<211>  128
<212>  PRT
<213>  Lama glama

<400>  82

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  83
<211>  128
<212>  PRT
<213>  Lama glama

<400>  83

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  84
<211>  120
<212>  PRT
<213>  Lama glama

<400>  84

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Arg Arg Gly Ser Cys Arg Gln Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Gln Val Thr Val Ser Ser 
        115                 120 


<210>  85
<211>  121
<212>  PRT
<213>  Lama glama

<400>  85

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ile Asn Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Asp Arg Tyr Ser Asp Cys Arg Gly Pro Tyr Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  86
<211>  121
<212>  PRT
<213>  Lama glama

<400>  86

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Val Pro Asp Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Ser Ser Gly Arg Asp Thr Ser Tyr Ala Asp Ser Ala 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Phe Arg Asn Asn Ala Ala Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Asn Leu Lys Leu Glu Asp Thr Gly Val Tyr Tyr Cys 
                85                  90                  95      


Val Lys Cys Leu Glu Val Trp Ala Thr Arg Glu Tyr Asp Gly Trp Gly 
            100                 105                 110         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120     


<210>  87
<211>  128
<212>  PRT
<213>  Lama glama

<400>  87

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val His Pro Gly Gly 
1               5                   10                  15      


Ser Leu Asn Leu Ser Cys Val Ala His Gly Phe Ser Leu Asp Ser His 
            20                  25                  30          


Asp Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Val Val 
        35                  40                  45              


Ala Cys Ile Lys His Arg Asp Gly Arg Ile Tyr Ile Leu Glu Ala Val 
    50                  55                  60                  


Lys Asp Arg Phe Val Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Glu Met Asn Asn Leu Ser Asp Glu Asp Thr Ala Val Tyr His Cys 
                85                  90                  95      


Ala Thr Ala Ser Ser Cys Ser Asp Asn Trp Trp Leu Leu Ile Gly Asp 
            100                 105                 110         


Ala Tyr Ala Gly Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125             


<210>  88
<211>  115
<212>  PRT
<213>  Lama glama

<400>  88

Glu Val Gln Leu Ala Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Thr Ser Gly Phe Ala Phe Arg Ser Tyr 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Asn Ser Asp Ser Arg Thr Ser Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Val Glu Asp Thr Ala Val Tyr Tyr Cys Ser 
                85                  90                  95      


Lys Gln Ser Pro Gly Thr Ser Gln Arg Gly Gln Gly Thr Gln Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  89
<211>  129
<212>  PRT
<213>  Lama glama

<400>  89

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Phe Thr Ser Ala Thr Tyr 
            20                  25                  30          


Ser Ile Ala Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Gly Val 
        35                  40                  45              


Ser Cys Ile Ser Thr Gly Asp Gly Ser Thr Tyr Tyr Ala Pro Ala Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Ser Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Gly Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Arg Ala Gly Tyr Gly Ser Ala Trp Phe Cys Pro Leu Asp Pro 
            100                 105                 110         


Ser Leu Gln Tyr Asp Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  90
<211>  128
<212>  PRT
<213>  Lama glama

<400>  90

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Leu Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Phe Glu Phe Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


<210>  91
<211>  126
<212>  PRT
<213>  Lama glama

<400>  91

Gln Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Gly Leu Ser Cys Ala Ala Ser Gly Leu Ala Phe Arg Glu Tyr 
            20                  25                  30          


Ser Met Gly Trp Phe Arg Arg Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ala Ala Val Asp Trp Thr Gly Ile Gln Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Ala Thr Ile Ser Arg Asp Thr Ala Lys Ser Thr Val Phe Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Asn Pro Glu Asp Thr Ala Phe Tyr Tyr Cys Ala 
                85                  90                  95      


Ala Gly Lys Lys Leu Thr Gly Ile Val Leu Leu Thr Arg Arg Thr Glu 
            100                 105                 110         


Tyr Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125     


<210>  92
<211>  125
<212>  PRT
<213>  Lama glama

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala His Ser Gly Phe Thr Leu Asp Tyr Tyr 
            20                  25                  30          


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Ser Ser Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Arg Tyr Gly Ser Ser Cys Arg Gly Gly Gln Trp Asp Thr 
            100                 105                 110         


Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  93
<211>  125
<212>  PRT
<213>  Lama glama

<400>  93

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Asp Tyr Tyr 
            20                  25                  30          


Thr Ile Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Ala Val 
        35                  40                  45              


Ser Cys Ile Asn Arg Ser Asp Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Thr Thr Tyr Gly Thr Ser Cys Arg Gly Gly Gln Trp Asp Thr 
            100                 105                 110         


Gly Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        115                 120                 125 


<210>  94
<211>  254
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Arg Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asp Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Gly Arg Lys Tyr Phe His His Asn Ser Asp Phe Tyr Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Phe 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Phe Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp Trp 
225                 230                 235                 240 


Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                245                 250                 


<210>  95
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Trp Gln Leu Leu Leu Pro Thr Ala Leu Leu Leu Leu Val Ser Ala 
1               5                   10                  15      


Gly Met Arg Thr Glu Asp Leu Pro Lys Ala Val Val Phe Leu Glu Pro 
            20                  25                  30          


Gln Trp Tyr Ser Val Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln 
        35                  40                  45              


Gly Ala Tyr Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu 
    50                  55                  60                  


Ser Leu Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr 
65                  70                  75                  80  


Val Asn Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu 
                85                  90                  95      


Ser Asp Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu Leu Gln 
            100                 105                 110         


Ala Pro Arg Trp Val Phe Lys Glu Glu Asp Pro Ile His Leu Arg Cys 
        115                 120                 125             


His Ser Trp Lys Asn Thr Ala Leu His Lys Val Thr Tyr Leu Gln Asn 
    130                 135                 140                 


Gly Lys Asp Arg Lys Tyr Phe His His Asn Ser Asp Phe His Ile Pro 
145                 150                 155                 160 


Lys Ala Thr Leu Lys Asp Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val 
                165                 170                 175     


Gly Ser Lys Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 
            180                 185                 190         


Gly Leu Ala Val Ser Thr Ile Ser Ser Phe Ser Pro Pro Gly Tyr Gln 
        195                 200                 205             


Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr Gly 
    210                 215                 220                 


Leu Tyr Phe Ser Val Lys Thr Asn Ile 
225                 230             


<210>  96
<211>  116
<212>  PRT
<213>  Lama glama

<400>  96

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  97
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hCD16F1-1

<400>  97

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  98
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hCD16F1-2

<400>  98

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  99
<211>  119
<212>  PRT
<213>  Lama glama

<400>  99

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Thr Leu Ser Cys Arg Ala Ser Gly Phe Thr Phe Ser Asn His 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Phe Asn Gly His Ala Thr Arg Tyr Ala Asp Ser Leu 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Thr Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Arg Lys Gly Trp Asn Ala Thr Pro Gln Ile Gly Glu Arg Gly Arg Gly 
            100                 105                 110         


Thr Gln Val Thr Val Ser Ser 
        115                 


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L1

<400>  100

Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   


<210>  101
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L2


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat = 1-35

<220>
<221>  REPEAT
<222>  (5)..(9)
<223>  repeat = 0-35

<400>  101

Gly Gly Gly Ser Ser Gly Gly Gly Ser 
1               5                   


<210>  102
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L3

<400>  102

Ala Ala Ala 
1           


<210>  103
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L4


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  Repeat = 1-35

<400>  103

Gly Gly Gly Gly Ser 
1               5   


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*3

<400>  104

Gly Gly Arg Gly Pro Leu Gly Leu Ala Gly Ser Arg Ser Ala Phe Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  105
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*4

<400>  105

Gly Ser Pro Leu Gly Leu Ala Gly Ser 
1               5                   


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*5

<400>  106

Gly Gly Ser Gly Pro Leu Gly Leu Ala Gly Ser Arg Ser Ala Phe Gly 
1               5                   10                  15      


<210>  107
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*6

<400>  107

Gly Pro Leu Gly Leu Ala Gly Ser Arg Ser Ala Gly Gly Ser Gln Val 
1               5                   10                  15      


Gln Leu 
        


<210>  108
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*7

<400>  108

Gly Ser Gly Pro Leu Gly Leu Ala Ala Arg Ser Ala Gly Gly Ser 
1               5                   10                  15  


<210>  109
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*8

<400>  109

Gly Ser Gly Pro Leu Gly Leu Ala Ala Arg Ser Ala Phe Gly Gly Ser 
1               5                   10                  15      


<210>  110
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*9

<400>  110

Gly Gly Ser Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg 
1               5                   10                  15      


Gln Val Gly Gly Ser 
            20      


<210>  111
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*10

<400>  111

Gly Gly Ser Gly Arg Ser Ala Pro Leu Gly Leu Gly Arg Gln Ala Arg 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  112
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*11

<400>  112

Gly Gly Ser Pro Leu Gly Leu Ala Arg Gln Ala Arg Gly Ser Gly Arg 
1               5                   10                  15      


Ser Ala Gly Gly Ser 
            20      


<210>  113
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*12

<400>  113

Gly Gly Ser Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg 
1               5                   10                  15      


Val Val Gly Gly Ser 
            20      


<210>  114
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*13

<400>  114

Gly Ser Arg Gln Ala Arg Val Val Gly Ser 
1               5                   10  


<210>  115
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*14

<400>  115

Gly Ser Arg Gln Arg Arg Val Val Gly Ser 
1               5                   10  


<210>  116
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*15

<400>  116

Gly Ser Arg Gln Ala Arg Gly Ser 
1               5               


<210>  117
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*16

<400>  117

Gly Ser Arg Gln Arg Arg Gly Ser 
1               5               


<210>  118
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*17

<400>  118

Gly Ser Arg Gln Ala Arg Gly Gly Ser 
1               5                   


<210>  119
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker L11*18

<400>  119

Gly Ser Arg Gln Arg Arg Gly Gly Ser 
1               5                   


<210>  120
<211>  401
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hHS5-L11*3-hA09-10-2-L1-hPL16

<400>  120

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
    290                 295                 300                 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
                325                 330                 335     


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
            340                 345                 350         


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
    370                 375                 380                 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
385                 390                 395                 400 


Ser 
    


<210>  121
<211>  533
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hHS5-L11*3-hA09-10-2-L3-A09-10-L1-hPL16

<400>  121

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                405                 410                 415     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            420                 425                 430         


Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln 
        435                 440                 445             


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly 
    450                 455                 460                 


Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
465                 470                 475                 480 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                485                 490                 495     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile 
            500                 505                 510         


Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln 
        515                 520                 525             


Val Thr Val Ser Ser 
    530             


<210>  122
<211>  660
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hHS5-L11*3- 
       hA09-10-2-L3-A09-10-L1-hPL16-L3-hPL16

<400>  122

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
                405                 410                 415     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            420                 425                 430         


Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln 
        435                 440                 445             


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly 
    450                 455                 460                 


Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
465                 470                 475                 480 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                485                 490                 495     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile 
            500                 505                 510         


Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln 
        515                 520                 525             


Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly 
    530                 535                 540                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
545                 550                 555                 560 


Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala 
                565                 570                 575     


Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr 
            580                 585                 590         


Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        595                 600                 605             


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
    610                 615                 620                 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala 
625                 630                 635                 640 


Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val 
                645                 650                 655     


Thr Val Ser Ser 
            660 


<210>  123
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09 -10-1-L1- hHS5-L1-hPL16

<400>  123

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly 
            180                 185                 190         


Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile 
        195                 200                 205             


Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr 
225                 230                 235                 240 


Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met 
    290                 295                 300                 


Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser 
305                 310                 315                 320 


Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        355                 360                 365             


Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 


<210>  124
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09-10-2-L3-A09-10-L1-hHS5-L1-hPL16

<400>  124

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
    290                 295                 300                 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
305                 310                 315                 320 


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
        355                 360                 365             


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu 
            420                 425                 430         


Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
465                 470                 475                 480 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520                 525     


<210>  125
<211>  653
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody 
       hA09-10-2-L3-A09-10-L1-hHS5-L1-hPL16-L3-hPL16

<400>  125

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
    290                 295                 300                 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
305                 310                 315                 320 


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
        355                 360                 365             


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu 
            420                 425                 430         


Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
465                 470                 475                 480 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        515                 520                 525             


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    530                 535                 540                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr 
545                 550                 555                 560 


Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                565                 570                 575     


Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser 
            580                 585                 590         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        595                 600                 605             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                645                 650             


<210>  126
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09-10-3-L1-hHS5-L1-hPL16-L3-hPL16

<400>  126

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly 
            180                 185                 190         


Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile 
        195                 200                 205             


Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr 
225                 230                 235                 240 


Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met 
    290                 295                 300                 


Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser 
305                 310                 315                 320 


Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        355                 360                 365             


Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln 
385                 390                 395                 400 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                405                 410                 415     


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
            420                 425                 430         


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
        435                 440                 445             


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
                485                 490                 495     


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
            500                 505                 510         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520     


<210>  127
<211>  394
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hHS5-L11*3-hA09-10-3-L1-H33-14

<400>  127

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
            260                 265                 270         


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
        275                 280                 285             


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
    290                 295                 300                 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
305                 310                 315                 320 


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
                325                 330                 335     


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
            340                 345                 350         


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
        355                 360                 365             


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
    370                 375                 380                 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 


<210>  128
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hHS5-L11*3-hA09-10-2-L3-A09-10-L1-H33-14

<400>  128

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
                405                 410                 415     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            420                 425                 430         


Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln 
        435                 440                 445             


Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn 
    450                 455                 460                 


Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
465                 470                 475                 480 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
                485                 490                 495     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly 
            500                 505                 510         


Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520                 525     


<210>  129
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody 
       hHS5-L1-hA09-10-2-L3-A09-10-L1-H33-14-L3-H33-14

<400>  129

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
305                 310                 315                 320 


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
            340                 345                 350         


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
        355                 360                 365             


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu 
            420                 425                 430         


Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
465                 470                 475                 480 


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly 
            500                 505                 510         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
        515                 520                 525             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    530                 535                 540                 


Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg 
545                 550                 555                 560 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn 
                565                 570                 575     


Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile 
            580                 585                 590         


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
        595                 600                 605             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly 
    610                 615                 620                 


Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
625                 630                 635                 


<210>  130
<211>  646
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody 
       hHS5-L11*3-hA09-10-2-L3-A09-10-L1-H33-14-L3-H3-14

<400>  130

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Pro Leu 
        115                 120                 125             


Gly Leu Ala Gly Arg Ser Ala Phe Gly Gly Ser Glu Val Gln Leu Val 
    130                 135                 140                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
145                 150                 155                 160 


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
                165                 170                 175     


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
            180                 185                 190         


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
        195                 200                 205             


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
    210                 215                 220                 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
225                 230                 235                 240 


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
                245                 250                 255     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
                405                 410                 415     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            420                 425                 430         


Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln 
        435                 440                 445             


Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn 
    450                 455                 460                 


Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
465                 470                 475                 480 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
                485                 490                 495     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly 
            500                 505                 510         


Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        515                 520                 525             


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    530                 535                 540                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile 
545                 550                 555                 560 


Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                565                 570                 575     


Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser 
            580                 585                 590         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        595                 600                 605             


Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr 
625                 630                 635                 640 


Gln Val Thr Val Ser Ser 
                645     


<210>  131
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09-10-3-L1-hHS5-L1-H33-14

<400>  131

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly 
            180                 185                 190         


Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile 
        195                 200                 205             


Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr 
225                 230                 235                 240 


Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met 
    290                 295                 300                 


Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg 
305                 310                 315                 320 


Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
            340                 345                 350         


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala 
        355                 360                 365             


Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser 
385         


<210>  132
<211>  519
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09-10-2-L3-A09-10-L1-hHS5-L1-H33-14

<400>  132

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
    290                 295                 300                 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
305                 310                 315                 320 


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
        355                 360                 365             


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu 
            420                 425                 430         


Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
465                 470                 475                 480 


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly 
            500                 505                 510         


Thr Gln Val Thr Val Ser Ser 
        515                 


<210>  133
<211>  507
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hA09-10-L1-hHS5-L1-H33-14-L3-H33-14

<400>  133

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu 
    130                 135                 140                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
145                 150                 155                 160 


Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg 
                165                 170                 175     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly 
            180                 185                 190         


Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile 
        195                 200                 205             


Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
    210                 215                 220                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr 
225                 230                 235                 240 


Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val 
            260                 265                 270         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met 
    290                 295                 300                 


Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg 
305                 310                 315                 320 


Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
            340                 345                 350         


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala 
        355                 360                 365             


Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr 
        435                 440                 445             


Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505         


<210>  134
<211>  639
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody 
       hA09-10-2-L3-A09-10-L1-hHS5-L1-H33-14-L3-H33-14

<400>  134

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
65                  70                  75                  80  


Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
145                 150                 155                 160 


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
                165                 170                 175     


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
            180                 185                 190         


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        195                 200                 205             


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
    210                 215                 220                 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
225                 230                 235                 240 


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
                245                 250                 255     


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
            260                 265                 270         


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
        275                 280                 285             


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
    290                 295                 300                 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
305                 310                 315                 320 


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
        355                 360                 365             


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu 
            420                 425                 430         


Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
465                 470                 475                 480 


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly 
            500                 505                 510         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
        515                 520                 525             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    530                 535                 540                 


Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg 
545                 550                 555                 560 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn 
                565                 570                 575     


Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile 
            580                 585                 590         


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
        595                 600                 605             


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly 
    610                 615                 620                 


Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
625                 630                 635                 


<210>  135
<211>  374
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody H33-14-L1-hHS5-L1-CD16F1

<400>  135

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
                165                 170                 175     


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
        275                 280                 285             


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
    290                 295                 300                 


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Gln Val Thr Val Ser Ser 
    370                 


<210>  136
<211>  493
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody H33-14-L1-hHS5-L1-CD16F1-L3-CD16F1

<400>  136

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val 
        115                 120                 125             


Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    130                 135                 140                 


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met 
145                 150                 155                 160 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala 
                165                 170                 175     


Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser 
    210                 215                 220                 


Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            260                 265                 270         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
        275                 280                 285             


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
    290                 295                 300                 


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
305                 310                 315                 320 


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
                325                 330                 335     


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
            340                 345                 350         


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
        355                 360                 365             


Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser 
    370                 375                 380                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
385                 390                 395                 400 


Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln 
                405                 410                 415     


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val 
            420                 425                 430         


Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
        435                 440                 445             


Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
    450                 455                 460                 


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly 
465                 470                 475                 480 


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                485                 490             


<210>  137
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody H33-14-L3-H33-14-L1-hHS5-L1-CD16F1

<400>  137

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr 
305                 310                 315                 320 


Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg 
            340                 345                 350         


Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg 
                405                 410                 415     


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly 
            420                 425                 430         


Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
    450                 455                 460                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr 
465                 470                 475                 480 


Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                485                 490                 


<210>  138
<211>  613
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody H33-14-L3-H33-14-L1-hHS5-L1-CD16F1-L3-CD16F1

<400>  138

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr 
    290                 295                 300                 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr 
305                 310                 315                 320 


Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg 
            340                 345                 350         


Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg 
                405                 410                 415     


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly 
            420                 425                 430         


Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
        435                 440                 445             


Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
    450                 455                 460                 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr 
465                 470                 475                 480 


Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
                485                 490                 495     


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            500                 505                 510         


Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala 
        515                 520                 525             


Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
    530                 535                 540                 


Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val 
545                 550                 555                 560 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr 
                565                 570                 575     


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
            580                 585                 590         


Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln 
        595                 600                 605             


Val Thr Val Ser Ser 
    610             


<210>  139
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L1-hHS5-L1-CD16F1

<400>  139

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly 
        195                 200                 205             


Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala 
225                 230                 235                 240 


Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val 
305                 310                 315                 320 


Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly 
        355                 360                 365             


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    370                 375                 380     


<210>  140
<211>  508
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L3-hPL16-L1-hHS5-L1-CD16F1

<400>  140

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                165                 170                 175     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
        275                 280                 285             


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
305                 310                 315                 320 


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
                325                 330                 335     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
        355                 360                 365             


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val 
                405                 410                 415     


Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala 
            420                 425                 430         


Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg 
        435                 440                 445             


Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            500                 505             


<210>  141
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L1-hHS5-L1-CD16F1-L3-CD16F1

<400>  141

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly 
        195                 200                 205             


Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala 
225                 230                 235                 240 


Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val 
305                 310                 315                 320 


Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly 
        355                 360                 365             


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
    370                 375                 380                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
385                 390                 395                 400 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                405                 410                 415     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            420                 425                 430         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        435                 440                 445             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    450                 455                 460                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
465                 470                 475                 480 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ser 
            500 


<210>  142
<211>  627
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L3-hPL16-L1-hHS5-L1-CD16F1-L3-CD16F1

<400>  142

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                165                 170                 175     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
        275                 280                 285             


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
305                 310                 315                 320 


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
                325                 330                 335     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
        355                 360                 365             


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val 
                405                 410                 415     


Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala 
            420                 425                 430         


Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg 
        435                 440                 445             


Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn 
                485                 490                 495     


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
            500                 505                 510         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        515                 520                 525             


Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val 
    530                 535                 540                 


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
545                 550                 555                 560 


Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly 
                565                 570                 575     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln 
            580                 585                 590         


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
        595                 600                 605             


Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
    610                 615                 620                 


Val Ser Ser 
625         


<210>  143
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hLG9-L1-hHS5-L1-hPL16 (005R)

<400>  143

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly 
            180                 185                 190         


Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser 
        195                 200                 205             


Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr 
225                 230                 235                 240 


Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
305                 310                 315                 320 


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
        355                 360                 365             


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390             


<210>  144
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hLG9-L3-hLG9-L1-hHS5-L1-hPL16

<400>  144

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile 
145                 150                 155                 160 


Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg 
                165                 170                 175     


Glu Gly Val Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val 
225                 230                 235                 240 


Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn 
305                 310                 315                 320 


Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu 
        355                 360                 365             


Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            420                 425                 430         


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        435                 440                 445             


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520                 


<210>  145
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hLG9-L1-hHS5-L1-hPL16-L3-hPL16

<400>  145

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
    130                 135                 140                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
145                 150                 155                 160 


Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln 
                165                 170                 175     


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly 
            180                 185                 190         


Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser 
        195                 200                 205             


Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    210                 215                 220                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr 
225                 230                 235                 240 


Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
    290                 295                 300                 


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
305                 310                 315                 320 


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
                325                 330                 335     


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
            340                 345                 350         


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
        355                 360                 365             


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu 
385                 390                 395                 400 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                405                 410                 415     


Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp 
            420                 425                 430         


Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn 
        435                 440                 445             


Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    450                 455                 460                 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
465                 470                 475                 480 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg 
                485                 490                 495     


Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Gln Val Thr Val Ser Ser 
        515                 520 


<210>  146
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hLG9-L3-hLG9-L1-hHS5-L1-hPL16-L3-hPL16

<400>  146

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr 
            20                  25                  30          


Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val 
        35                  40                  45              


Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr 
            100                 105                 110         


Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125             


Ala Ala Ala Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile 
145                 150                 155                 160 


Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln Ala Pro Gly Lys Gly Arg 
                165                 170                 175     


Glu Gly Val Ala Ala Ile Asp Asp Ser Asp Glu Ser Thr Tyr Tyr Ala 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
        195                 200                 205             


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met Ile Asp Gly Val Asp Val 
225                 230                 235                 240 


Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
                245                 250                 255     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
            260                 265                 270         


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        275                 280                 285             


Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp 
    290                 295                 300                 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn 
305                 310                 315                 320 


Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                325                 330                 335     


Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn 
            340                 345                 350         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu 
        355                 360                 365             


Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly 
    370                 375                 380                 


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
385                 390                 395                 400 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
                405                 410                 415     


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            420                 425                 430         


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        435                 440                 445             


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    450                 455                 460                 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
465                 470                 475                 480 


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                485                 490                 495     


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
545                 550                 555                 560 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                565                 570                 575     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                645                 650     


<210>  147
<211>  393
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L1-hHS5-L1-hLG9

<400>  147

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly 
        195                 200                 205             


Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala 
225                 230                 235                 240 


Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp Asp Ser Asp 
305                 310                 315                 320 


Glu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met 
        355                 360                 365             


Ile Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser 
385                 390             


<210>  148
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L1-hHS5-L1-hLG9-L3-hLG9

<400>  148

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly 
        195                 200                 205             


Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala 
225                 230                 235                 240 


Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp Asp Ser Asp 
305                 310                 315                 320 


Glu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met 
        355                 360                 365             


Ile Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly 
    370                 375                 380                 


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu 
385                 390                 395                 400 


Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                405                 410                 415     


Ser Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp 
            420                 425                 430         


Phe Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp 
        435                 440                 445             


Asp Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
    450                 455                 460                 


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
465                 470                 475                 480 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala 
                485                 490                 495     


Ile Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp 
            500                 505                 510         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        515                 520                 


<210>  149
<211>  520
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L3-hPL16-L1-hHS5-L1-hLG9

<400>  149

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                165                 170                 175     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
        275                 280                 285             


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
305                 310                 315                 320 


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
                325                 330                 335     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
        355                 360                 365             


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                405                 410                 415     


Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln Ala 
            420                 425                 430         


Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp Asp Ser Asp Glu 
        435                 440                 445             


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
465                 470                 475                 480 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met Ile 
                485                 490                 495     


Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser 
        515                 520 


<210>  150
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Trispecific antibody hPL16-L3-hPL16-L1-hHS5-L1-hLG9-L3-hLG9

<400>  150

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                165                 170                 175     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
        275                 280                 285             


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
    290                 295                 300                 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
305                 310                 315                 320 


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
                325                 330                 335     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            340                 345                 350         


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
        355                 360                 365             


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                405                 410                 415     


Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp Phe Arg Gln Ala 
            420                 425                 430         


Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp Asp Ser Asp Glu 
        435                 440                 445             


Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
465                 470                 475                 480 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Ile Phe Met Ile 
                485                 490                 495     


Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp Ser Trp Gly Gln 
            500                 505                 510         


Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Leu 
        515                 520                 525             


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
    530                 535                 540                 


Cys Ala Ala Ser Gly Ser Thr Ile Asp Asp Tyr Pro Met Ser Trp Phe 
545                 550                 555                 560 


Arg Gln Ala Pro Gly Lys Gly Arg Glu Gly Val Ala Ala Ile Asp Asp 
                565                 570                 575     


Ser Asp Glu Ser Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
            580                 585                 590         


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
        595                 600                 605             


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Ala Ile 
    610                 615                 620                 


Phe Met Ile Asp Gly Val Asp Val Phe Leu Thr Tyr Tyr Tyr Asp Ser 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                645                 650     


<210>  151
<211>  381
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hPL16-L1-hHS5-L1-CD16F1

<400>  151

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
            20                  25                  30          


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu 
    130                 135                 140                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
145                 150                 155                 160 


Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys 
                165                 170                 175     


Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr 
            180                 185                 190         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly 
        195                 200                 205             


Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    210                 215                 220                 


Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala 
225                 230                 235                 240 


Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val 
305                 310                 315                 320 


Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly 
        355                 360                 365             


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    370                 375                 380     


<210>  152
<211>  654
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L1-hHS10-L1- 
       hA09-10-2-L3-A09-10-L1-hPL16 (015-3)

<400>  152

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Glu Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            260                 265                 270         


Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
        275                 280                 285             


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
    290                 295                 300                 


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
305                 310                 315                 320 


Asn Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
        355                 360                 365             


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
    370                 375                 380                 


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
385                 390                 395                 400 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
                405                 410                 415     


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
            420                 425                 430         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
        435                 440                 445             


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile 
    450                 455                 460                 


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
465                 470                 475                 480 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
                485                 490                 495     


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
            500                 505                 510         


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        515                 520                 525             


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
    530                 535                 540                 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu 
545                 550                 555                 560 


Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                565                 570                 575     


Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp 
            580                 585                 590         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
        595                 600                 605             


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
    610                 615                 620                 


Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu 
625                 630                 635                 640 


Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                645                 650                 


<210>  153
<211>  665
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hHS10-L11*12-CD16F1-L1-hA09-10-2-L3-A09-10-L1-hPL16

<400>  153

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
                165                 170                 175     


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            180                 185                 190         


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                405                 410                 415     


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
            420                 425                 430         


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        435                 440                 445             


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
    450                 455                 460                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
465                 470                 475                 480 


Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
            500                 505                 510         


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        515                 520                 525             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    530                 535                 540                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
545                 550                 555                 560 


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
                565                 570                 575     


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
            580                 585                 590         


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        595                 600                 605             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    610                 615                 620                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
625                 630                 635                 640 


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
                645                 650                 655     


Gln Gly Thr Gln Val Thr Val Ser Ser 
            660                 665 


<210>  154
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L1-hHS10-L1- A09-10-L1-hPL16 
       (015-2)

<400>  154

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
        275                 280                 285             


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
305                 310                 315                 320 


Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
                325                 330                 335     


Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
        355                 360                 365             


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
    370                 375                 380                 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
385                 390                 395                 400 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                405                 410                 415     


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
            420                 425                 430         


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
        435                 440                 445             


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
                485                 490                 495     


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
            500                 505                 510         


Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520     


<210>  155
<211>  792
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hHS10-L11*12-CD16F1-L1-hA09-10-2-L3-A09-10-L1-hPL16-L3-hPL16

<400>  155

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
                165                 170                 175     


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            180                 185                 190         


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                405                 410                 415     


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
            420                 425                 430         


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        435                 440                 445             


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
    450                 455                 460                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
465                 470                 475                 480 


Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
            500                 505                 510         


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        515                 520                 525             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
    530                 535                 540                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
545                 550                 555                 560 


Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser 
                565                 570                 575     


Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile 
            580                 585                 590         


Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
        595                 600                 605             


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
    610                 615                 620                 


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala 
625                 630                 635                 640 


Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly 
                645                 650                 655     


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu 
            660                 665                 670         


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
        675                 680                 685             


Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp 
    690                 695                 700                 


Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn 
705                 710                 715                 720 


Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe 
                725                 730                 735     


Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn 
            740                 745                 750         


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg 
        755                 760                 765             


Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln 
    770                 775                 780                 


Gly Thr Gln Val Thr Val Ser Ser 
785                 790         


<210>  156
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS10-L1-hA09-10-2-L3-A09-10-L1-hPL16-L3-hPL16  (1511)

<400>  156

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
        275                 280                 285             


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
                325                 330                 335     


Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
        355                 360                 365             


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
    370                 375                 380                 


Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
            420                 425                 430         


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
        435                 440                 445             


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    450                 455                 460                 


Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu 
465                 470                 475                 480 


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
                485                 490                 495     


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    530                 535                 540                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr 
545                 550                 555                 560 


Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                565                 570                 575     


Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser 
            580                 585                 590         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        595                 600                 605             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
                645                 650                 655     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            660                 665                 670         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
        675                 680                 685             


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
    690                 695                 700                 


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
705                 710                 715                 720 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
                725                 730                 735     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            740                 745                 750         


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
        755                 760                 765             


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780 


<210>  157
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS10-L1-hA09-10-3-L3-hA09-10-4-L1-hPL16-L3-hPL16  
       (1518)

<400>  157

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
        275                 280                 285             


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
                325                 330                 335     


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
        355                 360                 365             


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
    370                 375                 380                 


Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
            420                 425                 430         


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
        435                 440                 445             


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    450                 455                 460                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
465                 470                 475                 480 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
                485                 490                 495     


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    530                 535                 540                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr 
545                 550                 555                 560 


Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                565                 570                 575     


Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser 
            580                 585                 590         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
        595                 600                 605             


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe 
625                 630                 635                 640 


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
                645                 650                 655     


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            660                 665                 670         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
        675                 680                 685             


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
    690                 695                 700                 


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
705                 710                 715                 720 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
                725                 730                 735     


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
            740                 745                 750         


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
        755                 760                 765             


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780 


<210>  158
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS10-L11*9-CD16F1- 
       L1-hA09-10-2-L3-A09-10-L1- H33-14-L3-H33-14

<400>  158

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
                165                 170                 175     


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            180                 185                 190         


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn 
    290                 295                 300                 


Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
305                 310                 315                 320 


Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser 
                325                 330                 335     


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr 
            340                 345                 350         


Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr 
        355                 360                 365             


Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr 
    370                 375                 380                 


Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
385                 390                 395                 400 


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
                405                 410                 415     


Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
            420                 425                 430         


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
        435                 440                 445             


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
    450                 455                 460                 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
465                 470                 475                 480 


Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr 
                485                 490                 495     


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
            500                 505                 510         


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
        515                 520                 525             


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln 
    530                 535                 540                 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
545                 550                 555                 560 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
                565                 570                 575     


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
            580                 585                 590         


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
        595                 600                 605             


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
    610                 615                 620                 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
625                 630                 635                 640 


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val 
                645                 650                 655     


Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            660                 665                 670         


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
        675                 680                 685             


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
    690                 695                 700                 


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
705                 710                 715                 720 


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
                725                 730                 735     


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            740                 745                 750         


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
        755                 760                 765             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    770                 775             


<210>  159
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS10-L1-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14 
       (3321)

<400>  159

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            260                 265                 270         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg 
        275                 280                 285             


Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys 
    290                 295                 300                 


Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn 
305                 310                 315                 320 


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe 
                325                 330                 335     


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
            340                 345                 350         


Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile 
        355                 360                 365             


Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val 
    370                 375                 380                 


Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
385                 390                 395                 400 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
                405                 410                 415     


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
            420                 425                 430         


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
        435                 440                 445             


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    450                 455                 460                 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
465                 470                 475                 480 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
                485                 490                 495     


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
            500                 505                 510         


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        515                 520                 525             


Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    530                 535                 540                 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile 
545                 550                 555                 560 


Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
                565                 570                 575     


Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser 
            580                 585                 590         


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val 
        595                 600                 605             


Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
    610                 615                 620                 


Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr 
625                 630                 635                 640 


Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser 
                645                 650                 655     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            660                 665                 670         


Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln 
        675                 680                 685             


Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn 
    690                 695                 700                 


Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
705                 710                 715                 720 


Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
                725                 730                 735     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly 
            740                 745                 750         


Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760                 765     


<210>  160
<211>  917
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multipecific antibody hHS10-L11*9-CD16F1-L1-CD16F1-L1- 
       hA09-10-2-L3-A09-10-L1- hPL-16-L3-hPL-16

<400>  160

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
                165                 170                 175     


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            180                 185                 190         


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
            260                 265                 270         


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        275                 280                 285             


Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val 
    290                 295                 300                 


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
305                 310                 315                 320 


Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly 
                325                 330                 335     


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln 
            340                 345                 350         


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
        355                 360                 365             


Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
    370                 375                 380                 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu 
385                 390                 395                 400 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
                405                 410                 415     


Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu 
            420                 425                 430         


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
        435                 440                 445             


Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly 
    450                 455                 460                 


Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln 
465                 470                 475                 480 


Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
                485                 490                 495     


His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr 
            500                 505                 510         


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala 
        515                 520                 525             


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
    530                 535                 540                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
545                 550                 555                 560 


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
                565                 570                 575     


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
            580                 585                 590         


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr 
        595                 600                 605             


Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
    610                 615                 620                 


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
625                 630                 635                 640 


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
            660                 665                 670         


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
        675                 680                 685             


Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg 
    690                 695                 700                 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser 
705                 710                 715                 720 


Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                725                 730                 735     


Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu 
            740                 745                 750         


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala 
        755                 760                 765             


Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr 
    770                 775                 780                 


Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser 
785                 790                 795                 800 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
                805                 810                 815     


Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln 
            820                 825                 830         


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly 
        835                 840                 845             


Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
    850                 855                 860                 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
865                 870                 875                 880 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile 
                885                 890                 895     


Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln 
            900                 905                 910         


Val Thr Val Ser Ser 
        915         


<210>  161
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L3-CD16F1-L1-hHS10-L1-hA09-10-2-L3-A09-10-L1-H33-14-L3-H33
       -14

<400>  161

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
    130                 135                 140                 


Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr 
                165                 170                 175     


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                245                 250                 255     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr 
            260                 265                 270         


Asp Ser Ala Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        275                 280                 285             


Arg Glu Phe Val Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr 
    290                 295                 300                 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
305                 310                 315                 320 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val 
            340                 345                 350         


Pro Gln Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        355                 360                 365             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val 
            500                 505                 510         


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu 
        515                 520                 525             


Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr 
    530                 535                 540                 


Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
545                 550                 555                 560 


Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val 
                565                 570                 575     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr 
            580                 585                 590         


Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
        595                 600                 605             


Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn 
    610                 615                 620                 


Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
                645                 650                 655     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
            660                 665                 670         


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
        675                 680                 685             


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
    690                 695                 700                 


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
705                 710                 715                 720 


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
                725                 730                 735     


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
            740                 745                 750         


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala 
        755                 760                 765             


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
    770                 775                 780                 


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
785                 790                 795                 800 


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
                805                 810                 815     


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
            820                 825                 830         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
        835                 840                 845             


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
    850                 855                 860                 


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
865                 870                 875                 880 


Val Thr Val Ser Ser 
                885 


<210>  162
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS10-L11*12-CD16F1-L3-CD16F1-L1- 
       hA09-10-2-L3-A09-10-L1-H33-14-L3-H33-14

<400>  162

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr 
            20                  25                  30          


Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr 
            100                 105                 110         


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Ser 
        115                 120                 125             


Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly 
    130                 135                 140                 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
145                 150                 155                 160 


Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser 
                165                 170                 175     


Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu 
            180                 185                 190         


Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser 
        195                 200                 205             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val 
    210                 215                 220                 


Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val 
305                 310                 315                 320 


Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
                325                 330                 335     


Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro 
            340                 345                 350         


Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly 
        355                 360                 365             


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
    370                 375                 380                 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
385                 390                 395                 400 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
                405                 410                 415     


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
            420                 425                 430         


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
        435                 440                 445             


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
    450                 455                 460                 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
465                 470                 475                 480 


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
                485                 490                 495     


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
            500                 505                 510         


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
        515                 520                 525             


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
    530                 535                 540                 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
545                 550                 555                 560 


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
                565                 570                 575     


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
            580                 585                 590         


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
        595                 600                 605             


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
    610                 615                 620                 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
        675                 680                 685             


Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr 
705                 710                 715                 720 


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
                725                 730                 735     


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly 
        755                 760                 765             


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu 
    770                 775                 780                 


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
785                 790                 795                 800 


Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp 
                805                 810                 815     


Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp 
            820                 825                 830         


Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe 
        835                 840                 845             


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser 
    850                 855                 860                 


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu 
865                 870                 875                 880 


Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                885                 890                 895     


Ser 
    


<210>  163
<211>  751
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L3-CD16F1-L1- 
       hA09-10-2-L3-A09-10-L1-H33-14-L3-H33-14

<400>  163

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
    130                 135                 140                 


Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr 
                165                 170                 175     


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
                245                 250                 255     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
            260                 265                 270         


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
        275                 280                 285             


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
    290                 295                 300                 


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
305                 310                 315                 320 


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
                325                 330                 335     


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
            340                 345                 350         


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
        355                 360                 365             


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
                405                 410                 415     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
            420                 425                 430         


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
    450                 455                 460                 


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
465                 470                 475                 480 


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
                485                 490                 495     


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
            500                 505                 510         


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
        515                 520                 525             


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu 
    530                 535                 540                 


Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu 
545                 550                 555                 560 


Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp 
                565                 570                 575     


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
            580                 585                 590         


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
        595                 600                 605             


Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly 
    610                 615                 620                 


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
625                 630                 635                 640 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
                645                 650                 655     


Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg 
            660                 665                 670         


Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn 
        675                 680                 685             


Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
705                 710                 715                 720 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly 
                725                 730                 735     


Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
            740                 745                 750     


<210>  164
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-hHS10-L1-CD16F1

<400>  164

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr 
    530                 535                 540                 


Asp Ser Ala Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
545                 550                 555                 560 


Arg Glu Phe Val Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr 
                565                 570                 575     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            580                 585                 590         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        595                 600                 605             


Val Tyr Tyr Cys Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val 
    610                 615                 620                 


Pro Gln Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                645                 650                 655     


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            660                 665                 670         


Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg 
        675                 680                 685             


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly 
    690                 695                 700                 


Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
705                 710                 715                 720 


Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
                725                 730                 735     


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr 
            740                 745                 750         


Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        755                 760                 765     


<210>  165
<211>  885
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-hHS10-L1-CD16F1-L3-CD16F1

<400>  165

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr 
    530                 535                 540                 


Asp Ser Ala Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
545                 550                 555                 560 


Arg Glu Phe Val Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr 
                565                 570                 575     


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
            580                 585                 590         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        595                 600                 605             


Val Tyr Tyr Cys Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val 
    610                 615                 620                 


Pro Gln Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu 
                645                 650                 655     


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
            660                 665                 670         


Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg 
        675                 680                 685             


Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly 
    690                 695                 700                 


Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
705                 710                 715                 720 


Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys 
                725                 730                 735     


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr 
            740                 745                 750         


Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
        755                 760                 765             


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
    770                 775                 780                 


Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala 
785                 790                 795                 800 


Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu 
                805                 810                 815     


Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val 
            820                 825                 830         


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr 
        835                 840                 845             


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
    850                 855                 860                 


Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln 
865                 870                 875                 880 


Val Thr Val Ser Ser 
                885 


<210>  166
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-CD16F1-L11*9-hHS10

<400>  166

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu 
    530                 535                 540                 


Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
545                 550                 555                 560 


Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala 
                565                 570                 575     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg 
            580                 585                 590         


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        595                 600                 605             


Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg Ser Ala Pro 
625                 630                 635                 640 


Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser Glu Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
        675                 680                 685             


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
    690                 695                 700                 


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
                725                 730                 735     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
            740                 745                 750         


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
        755                 760                 765             


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
    770                 775             


<210>  167
<211>  897
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       H33-14-L3-H33-14-L1-hA09-10-2-L3-A09-10-L1-CD16-F1-L3-CD16F1-L11*
       9-hHS10

<400>  167

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu 
    530                 535                 540                 


Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
545                 550                 555                 560 


Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala 
                565                 570                 575     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg 
            580                 585                 590         


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        595                 600                 605             


Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val 
625                 630                 635                 640 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                645                 650                 655     


Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr 
            660                 665                 670         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser 
        675                 680                 685             


Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu 
705                 710                 715                 720 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn 
                725                 730                 735     


Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            740                 745                 750         


Gly Ser Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln 
        755                 760                 765             


Val Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    770                 775                 780                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr 
785                 790                 795                 800 


Asp Ser Ala Tyr Arg Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                805                 810                 815     


Arg Glu Phe Val Ser Ala Ile Asn Trp Ser Asp Gly Arg Thr Tyr Tyr 
            820                 825                 830         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        835                 840                 845             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    850                 855                 860                 


Val Tyr Tyr Cys Ala Ala Asp Pro Asp Ser Arg Leu Tyr Tyr Thr Val 
865                 870                 875                 880 


Pro Gln Asn Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
                885                 890                 895     


Ser 
    


<210>  168
<211>  651
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L1-hHS5-L1- 
       hA09-10-2-L3-A09-10-L1-hPL16 (015-3-HS5)

<400>  168

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
        275                 280                 285             


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    290                 295                 300                 


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
                325                 330                 335     


Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
        355                 360                 365             


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
                405                 410                 415     


Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn 
        435                 440                 445             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser 
                485                 490                 495     


Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
545                 550                 555                 560 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                565                 570                 575     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                645                 650     


<210>  169
<211>  663
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS5-L11*9-CD16F1-L1- 
       hA09-10-2-L3-A09-10-L1-hPL16

<400>  169

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg 
        115                 120                 125             


Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala 
    290                 295                 300                 


Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
305                 310                 315                 320 


Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
                325                 330                 335     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu 
            340                 345                 350         


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        355                 360                 365             


Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met 
    370                 375                 380                 


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
385                 390                 395                 400 


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                405                 410                 415     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
            420                 425                 430         


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        435                 440                 445             


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
    450                 455                 460                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
465                 470                 475                 480 


Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
            500                 505                 510         


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        515                 520                 525             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
    530                 535                 540                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
545                 550                 555                 560 


Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val 
                565                 570                 575     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp 
            580                 585                 590         


Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        595                 600                 605             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    610                 615                 620                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr 
625                 630                 635                 640 


Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly 
                645                 650                 655     


Thr Gln Val Thr Val Ser Ser 
            660             


<210>  170
<211>  526
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L1-hHS5-L1- A09-10-L1 -hPL16 
       (015-2-HS5)

<400>  170

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
145                 150                 155                 160 


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                165                 170                 175     


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
225                 230                 235                 240 


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
            260                 265                 270         


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
        275                 280                 285             


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
    290                 295                 300                 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
305                 310                 315                 320 


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
                325                 330                 335     


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
            340                 345                 350         


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
        355                 360                 365             


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
    370                 375                 380                 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
385                 390                 395                 400 


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
                405                 410                 415     


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu 
            420                 425                 430         


Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        435                 440                 445             


Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp 
    450                 455                 460                 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
465                 470                 475                 480 


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                485                 490                 495     


Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu 
            500                 505                 510         


Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        515                 520                 525     


<210>  171
<211>  796
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS5-L11*9-CD16F1- 
       L1-A09-10-L3-A0910-L1-hPL16-L3-hPL16

<400>  171

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg 
        115                 120                 125             


Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala 
    290                 295                 300                 


Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
305                 310                 315                 320 


Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Ala Lys 
                325                 330                 335     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu 
            340                 345                 350         


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        355                 360                 365             


Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met 
    370                 375                 380                 


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
385                 390                 395                 400 


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                405                 410                 415     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
            420                 425                 430         


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        435                 440                 445             


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
    450                 455                 460                 


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
465                 470                 475                 480 


Thr Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
            500                 505                 510         


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        515                 520                 525             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val 
    530                 535                 540                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
545                 550                 555                 560 


Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val 
                565                 570                 575     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp 
            580                 585                 590         


Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
        595                 600                 605             


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
    610                 615                 620                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr 
625                 630                 635                 640 


Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly 
                645                 650                 655     


Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
            660                 665                 670         


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        675                 680                 685             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr 
    690                 695                 700                 


Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
705                 710                 715                 720 


Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val 
                725                 730                 735     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            740                 745                 750         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        755                 760                 765             


Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp 
    770                 775                 780                 


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
785                 790                 795     


<210>  172
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L1-A09-10-L3-A09-10-L1-hPL16-L3-hPL16 

(1511-HS5)

<400>  172

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
        275                 280                 285             


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    290                 295                 300                 


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
305                 310                 315                 320 


Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
                325                 330                 335     


Thr Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
        355                 360                 365             


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
                405                 410                 415     


Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn 
        435                 440                 445             


Ile Asn Tyr Ala Asp Ser Ala Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Lys Pro Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser 
                485                 490                 495     


Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
545                 550                 555                 560 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                565                 570                 575     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met 
        675                 680                 685             


Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser 
    690                 695                 700                 


Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
705                 710                 715                 720 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                725                 730                 735     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            740                 745                 750         


Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp 
        755                 760                 765             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775             


<210>  173
<211>  778
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L1-hA09-10-3-L3-hA09-10-4-L1-hPL16-L3-hPL16  
       (1518-HS5)

<400>  173

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
        275                 280                 285             


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    290                 295                 300                 


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
                325                 330                 335     


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
        355                 360                 365             


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
                405                 410                 415     


Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn 
        435                 440                 445             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser 
                485                 490                 495     


Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser 
545                 550                 555                 560 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser 
                565                 570                 575     


Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        595                 600                 605             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    610                 615                 620                 


Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr 
625                 630                 635                 640 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val 
                645                 650                 655     


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
            660                 665                 670         


Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr Tyr Ser Met 
        675                 680                 685             


Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ser 
    690                 695                 700                 


Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
705                 710                 715                 720 


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
                725                 730                 735     


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
            740                 745                 750         


Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe Asp Tyr Trp 
        755                 760                 765             


Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775             


<210>  174
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS5-L11*9-CD16F1- 
       L1-hA09-10-2-L3-A09-10-L1- H33-14-L3-H33-14

<400>  174

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg 
        115                 120                 125             


Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
            260                 265                 270         


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
        275                 280                 285             


Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala 
    290                 295                 300                 


Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
305                 310                 315                 320 


Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
                325                 330                 335     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu 
            340                 345                 350         


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        355                 360                 365             


Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met 
    370                 375                 380                 


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
385                 390                 395                 400 


Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly 
                405                 410                 415     


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
            420                 425                 430         


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
        435                 440                 445             


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
    450                 455                 460                 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
465                 470                 475                 480 


Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val 
                485                 490                 495     


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
            500                 505                 510         


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
        515                 520                 525             


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val 
    530                 535                 540                 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
545                 550                 555                 560 


Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp 
                565                 570                 575     


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp 
            580                 585                 590         


Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
        595                 600                 605             


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
    610                 615                 620                 


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile 
625                 630                 635                 640 


Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                645                 650                 655     


Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            660                 665                 670         


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser 
        675                 680                 685             


Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg 
    690                 695                 700                 


Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser 
705                 710                 715                 720 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                725                 730                 735     


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
            740                 745                 750         


Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln 
        755                 760                 765             


Gly Thr Leu Val Thr Val Ser Ser 
    770                 775     


<210>  175
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L1-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14  
       (3211-HS5)

<400>  175

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
            260                 265                 270         


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe 
        275                 280                 285             


Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg 
    290                 295                 300                 


Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala 
305                 310                 315                 320 


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn 
                325                 330                 335     


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
            340                 345                 350         


Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr 
        355                 360                 365             


Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    370                 375                 380                 


Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
385                 390                 395                 400 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
                405                 410                 415     


Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro 
            420                 425                 430         


Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn 
        435                 440                 445             


Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    450                 455                 460                 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
465                 470                 475                 480 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser 
                485                 490                 495     


Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr 
            500                 505                 510         


Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gln 
        515                 520                 525             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    530                 535                 540                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala 
545                 550                 555                 560 


Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly 
                565                 570                 575     


Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys 
            580                 585                 590         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
        595                 600                 605             


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
    610                 615                 620                 


Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val 
625                 630                 635                 640 


Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly Gly 
                645                 650                 655     


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
            660                 665                 670         


Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro 
        675                 680                 685             


Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met 
    690                 695                 700                 


Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
705                 710                 715                 720 


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
                725                 730                 735     


Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg 
            740                 745                 750         


Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        755                 760                 


<210>  176
<211>  909
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hHS5-L11*9-CD16F1-L3-CD16F1-L1-hA09-10-2-L3-A09-10-L1-hPL-16-L3-h
       PL-16

<400>  176

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg 
        115                 120                 125             


Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
        275                 280                 285             


Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr 
305                 310                 315                 320 


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr 
        355                 360                 365             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
385                 390                 395                 400 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
                405                 410                 415     


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
        435                 440                 445             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
                485                 490                 495     


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            500                 505                 510         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        515                 520                 525             


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    530                 535                 540                 


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
545                 550                 555                 560 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
                565                 570                 575     


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            580                 585                 590         


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
        595                 600                 605             


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
    610                 615                 620                 


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            660                 665                 670         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu 
        675                 680                 685             


Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    690                 695                 700                 


Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp 
705                 710                 715                 720 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
                725                 730                 735     


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            740                 745                 750         


Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu 
        755                 760                 765             


Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala 
    770                 775                 780                 


Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly 
785                 790                 795                 800 


Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr Phe Leu Thr 
                805                 810                 815     


Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe 
            820                 825                 830         


Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr Ala Asp Ser 
        835                 840                 845             


Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 
    850                 855                 860                 


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
865                 870                 875                 880 


Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser Ser Glu Phe 
                885                 890                 895     


Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
            900                 905                 


<210>  177
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody CD16F1-L3-CD16F1-L1-hHS5-L1- 
       hA09-10-2-L3-A09-10-L1-H33-14-L3-H33-14

<400>  177

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
        115                 120                 125             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
    130                 135                 140                 


Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro 
145                 150                 155                 160 


Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr 
                165                 170                 175     


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
            180                 185                 190         


Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
        195                 200                 205             


Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr 
    210                 215                 220                 


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
225                 230                 235                 240 


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
                245                 250                 255     


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
            260                 265                 270         


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
        275                 280                 285             


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
    290                 295                 300                 


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
305                 310                 315                 320 


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
                325                 330                 335     


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
            340                 345                 350         


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
        355                 360                 365             


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
    370                 375                 380                 


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
385                 390                 395                 400 


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
                405                 410                 415     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
            420                 425                 430         


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
        435                 440                 445             


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
    450                 455                 460                 


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
465                 470                 475                 480 


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
                485                 490                 495     


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu 
            500                 505                 510         


Val Glu Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu 
        515                 520                 525             


Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu 
    530                 535                 540                 


Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala 
545                 550                 555                 560 


Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly 
                565                 570                 575     


Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln 
            580                 585                 590         


Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala 
        595                 600                 605             


His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr 
    610                 615                 620                 


Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
                645                 650                 655     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            660                 665                 670         


Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly 
        675                 680                 685             


Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr 
    690                 695                 700                 


Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
705                 710                 715                 720 


Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp 
                725                 730                 735     


Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly 
            740                 745                 750         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val 
        755                 760                 765             


Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu 
    770                 775                 780                 


Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met 
785                 790                 795                 800 


Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg 
                805                 810                 815     


Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly 
            820                 825                 830         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln 
        835                 840                 845             


Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala 
    850                 855                 860                 


Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr 
865                 870                 875                 880 


Val Ser Ser 
            


<210>  178
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS5-L11*9-CD16F1-L3-CD16F1-L1- 
       hA09-10-2-L3-A09-10-L1-H33-14-L3-H33-14

<400>  178

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg 
        115                 120                 125             


Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser 
    130                 135                 140                 


Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
145                 150                 155                 160 


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
                165                 170                 175     


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
            180                 185                 190         


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
        195                 200                 205             


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
225                 230                 235                 240 


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
                245                 250                 255     


Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser 
        275                 280                 285             


Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro 
    290                 295                 300                 


Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr 
305                 310                 315                 320 


Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr 
        355                 360                 365             


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
385                 390                 395                 400 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly 
                405                 410                 415     


Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly 
            420                 425                 430         


Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile 
        435                 440                 445             


Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
    450                 455                 460                 


Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp 
465                 470                 475                 480 


Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr 
                485                 490                 495     


Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln 
            500                 505                 510         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        515                 520                 525             


Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    530                 535                 540                 


Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg 
545                 550                 555                 560 


Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser 
                565                 570                 575     


Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
            580                 585                 590         


Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu 
        595                 600                 605             


Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu 
    610                 615                 620                 


Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly 
625                 630                 635                 640 


Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
                645                 650                 655     


Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro 
            660                 665                 670         


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu 
        675                 680                 685             


Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu 
    690                 695                 700                 


Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp 
705                 710                 715                 720 


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                725                 730                 735     


Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            740                 745                 750         


Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly 
        755                 760                 765             


Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    770                 775                 780                 


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
785                 790                 795                 800 


Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg 
                805                 810                 815     


Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn 
            820                 825                 830         


Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile 
        835                 840                 845             


Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu 
    850                 855                 860                 


Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly 
865                 870                 875                 880 


Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
                885                 890                 895 


<210>  179
<211>  764
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-hHS5-L1-CD16F1

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
    530                 535                 540                 


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
545                 550                 555                 560 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
                565                 570                 575     


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
            580                 585                 590         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        595                 600                 605             


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
    610                 615                 620                 


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                645                 650                 655     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val 
            660                 665                 670         


Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala 
        675                 680                 685             


Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg 
    690                 695                 700                 


Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
705                 710                 715                 720 


Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                725                 730                 735     


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn 
            740                 745                 750         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        755                 760                 


<210>  180
<211>  883
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-hHS5-L1-CD16F1-L3-CD16F1

<400>  180

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
    530                 535                 540                 


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
545                 550                 555                 560 


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
                565                 570                 575     


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
            580                 585                 590         


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
        595                 600                 605             


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
    610                 615                 620                 


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
625                 630                 635                 640 


Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly 
                645                 650                 655     


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val 
            660                 665                 670         


Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala 
        675                 680                 685             


Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg 
    690                 695                 700                 


Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
705                 710                 715                 720 


Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu 
                725                 730                 735     


Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn 
            740                 745                 750         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu 
        755                 760                 765             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    770                 775                 780                 


Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val 
785                 790                 795                 800 


Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala 
                805                 810                 815     


Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly 
            820                 825                 830         


Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln 
        835                 840                 845             


Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val 
    850                 855                 860                 


Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr 
865                 870                 875                 880 


Val Ser Ser 
            


<210>  181
<211>  776
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14-L1- 
       hA09-10-2-L3-A09-10-L1-CD16F1-L11*9-hHS5

<400>  181

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu 
    530                 535                 540                 


Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
545                 550                 555                 560 


Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala 
                565                 570                 575     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg 
            580                 585                 590         


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        595                 600                 605             


Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Ser Gly Arg Ser Ala Pro 
625                 630                 635                 640 


Leu Gly Leu Ala Arg Gln Ala Arg Gln Val Gly Gly Ser Glu Val Gln 
                645                 650                 655     


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
        675                 680                 685             


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
    690                 695                 700                 


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
                725                 730                 735     


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
            740                 745                 750         


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
        755                 760                 765             


Gly Thr Gln Val Thr Val Ser Ser 
    770                 775     


<210>  182
<211>  895
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14- 
       L1-hA09-10-2-L3-A09-10-L1-CD16-F1-L3-CD16F1-L11*9-hHS5

<400>  182

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
                245                 250                 255     


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
            260                 265                 270         


Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala 
        275                 280                 285             


Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly Gly 
    290                 295                 300                 


Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
305                 310                 315                 320 


Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser Ser Leu Glu Pro 
                325                 330                 335     


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro 
            340                 345                 350         


Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly 
        355                 360                 365             


Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu 
    370                 375                 380                 


Ser Gly Gly Gly Leu Val Gln Ala Gly Gly Ser Leu Arg Leu Ser Cys 
385                 390                 395                 400 


Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp 
                405                 410                 415     


Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser 
            420                 425                 430         


Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe 
        435                 440                 445             


Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met Ser 
    450                 455                 460                 


Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr 
465                 470                 475                 480 


Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr 
                485                 490                 495     


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
            500                 505                 510         


Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
        515                 520                 525             


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu 
    530                 535                 540                 


Phe Ser Ala Arg Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln 
545                 550                 555                 560 


Arg Glu Leu Val Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala 
                565                 570                 575     


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg 
            580                 585                 590         


Ala Val Tyr Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val 
        595                 600                 605             


Tyr Tyr Cys Asn Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln 
    610                 615                 620                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val 
625                 630                 635                 640 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                645                 650                 655     


Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg Val Met Gly Trp Tyr 
            660                 665                 670         


Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val Ala Ala Ile Thr Ser 
        675                 680                 685             


Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile 
    690                 695                 700                 


Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu Gln Met Asn Ser Leu 
705                 710                 715                 720 


Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn Val Asn Leu Tyr Asn 
                725                 730                 735     


Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly 
            740                 745                 750         


Gly Ser Gly Arg Ser Ala Pro Leu Gly Leu Ala Arg Gln Ala Arg Gln 
        755                 760                 765             


Val Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    770                 775                 780                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
785                 790                 795                 800 


Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu 
                805                 810                 815     


Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr 
            820                 825                 830         


Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala 
        835                 840                 845             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    850                 855                 860                 


Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly 
865                 870                 875                 880 


Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
                885                 890                 895 


<210>  183
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L4-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14 
       (3321-HS5-GS15)

<400>  183

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  184
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L1-hA09-10-3-L3-hA09-10-4-L1-hPL16-L3-hPL16 
       (1518-HS5-GS15)

<400>  184

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  185
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-45- 
       L1-hPL16-L3-hPL-16

<400>  185

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  186
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-45- 
       L1-hPL16-L3-hPL-16

<400>  186

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  187
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-55-L1-hPL16-L3-hPL16

<400>  187

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Glu 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  188
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-55-L1-hPL16-L3-hPl-16

<400>  188

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Glu 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  189
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-66- 
       L1-hPL16-L3-hPL-16

<400>  189

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  190
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-66- 
       L1-hPL16-L3-hPL-16

<400>  190

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  191
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-77- 
       L1-hPL16-L3-hPL-16

<400>  191

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  192
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-77- 
       L1-hPL16-L3-hPL-16

<400>  192

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  193
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-88- 
       L1-hPL16-L3-hPL-16

<400>  193

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  194
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-88- 
       L1-hPL16-L3-hPL-16

<400>  194

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  195
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-99- 
       L1-hPL16-L3-hPL-16

<400>  195

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  196
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-99- 
       L1-hPL16-L3-hPL-16

<400>  196

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  197
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-100- 
       L1-hPL16-L3-hPL-16

<400>  197

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  198
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-100-L1-hPL16-L3-hPL-16

<400>  198

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly 
545                 550                 555                 560 


Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr 
            580                 585                 590         


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
        595                 600                 605             


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg 
625                 630                 635                 640 


Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
                645                 650                 655     


Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
            660                 665                 670         


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Thr 
        675                 680                 685             


Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Glu 
    690                 695                 700                 


Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr Tyr Tyr 
705                 710                 715                 720 


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
                725                 730                 735     


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
            740                 745                 750         


Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys Arg Ser 
        755                 760                 765             


Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
    770                 775                 780                 


<210>  199
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS5-L4-hA09-10-L3-hA09-10-L1-H33-14-L3-H33-14  
       (3321-HS5-GS15)

<400>  199

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  200
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14

<400>  200

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  201
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14

<400>  201

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  202
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-45- 
       L1-H33-14-L3-H33-14

<400>  202

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  203
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-45- 
       L1-H33-14-L3-H33-14

<400>  203

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Thr Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  204
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-55-L1-H33-14-L3-H33-14

<400>  204

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Glu 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  205
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-55- 
       L1-H33-14-L3-H33-14

<400>  205

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Glu 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Val Val Arg Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  206
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L4-hA09-10-77- 
       L1-H33-14-L3-H33-14

<400>  206

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  207
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-2-L1-hHS5-L4-hA09-10-77- 
       L1-H33-14-L3-H33-14

<400>  207

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  208
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hCD16F1-1-L1-hHS5-L1-hA09-10-66-L1 
       -H33-14-L3-H33-14

<400>  208

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  209
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-66-L1-H33-14-L3-H33-14

<400>  209

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Asp Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  210
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-88-L1-H33-14-L3-H33-14

<400>  210

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  211
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-88-L1-H33-14-L3-H33-14

<400>  211

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  212
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-99-L1-H33-14-L3-H33-14

<400>  212

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  213
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-99-L1-H33-14-L3-H33-14

<400>  213

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Lys 
            340                 345                 350         


Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  214
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-1-L1-hHS5-L4-hA09-10-100-L1-H33-14-L3-H33-14

<400>  214

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  215
<211>  770
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       hCD16F1-2-L1-hHS5-L4-hA09-10-100-L1-H33-14-L3-H33-14

<400>  215

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ser Ala Ile Thr Ser Gly Val Arg Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn 
    210                 215                 220                 


Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                245                 250                 255     


Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
            260                 265                 270         


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
        275                 280                 285             


Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly Trp Phe Arg Gln 
    290                 295                 300                 


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Ser Arg Ser Gly 
305                 310                 315                 320 


Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
                325                 330                 335     


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Ser Ser Leu Arg 
            340                 345                 350         


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu Leu Leu 
        355                 360                 365             


Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp Gly Gln 
    370                 375                 380                 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
385                 390                 395                 400 


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
                405                 410                 415     


Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Met Gly 
            420                 425                 430         


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
        435                 440                 445             


Ser Arg Ser Gly Gly Asn Ile Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
    450                 455                 460                 


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
465                 470                 475                 480 


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His 
                485                 490                 495     


Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn 
            500                 505                 510         


Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly 
        515                 520                 525             


Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
    530                 535                 540                 


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg 
545                 550                 555                 560 


Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys 
                565                 570                 575     


Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg 
            580                 585                 590         


Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
        595                 600                 605             


Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr 
    610                 615                 620                 


Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp 
625                 630                 635                 640 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
                645                 650                 655     


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
            660                 665                 670         


Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala 
        675                 680                 685             


Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile 
    690                 695                 700                 


Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg 
705                 710                 715                 720 


Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met 
                725                 730                 735     


Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp 
            740                 745                 750         


Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val 
        755                 760                 765             


Ser Ser 
    770 


<210>  216
<211>  772
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS10-L4-hA09-10-3-L3-hA09-10-4-L1-H33-14-L3-H33-14 
       (3321-GS15)

<400>  216

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg 
305                 310                 315                 320 


Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu 
        355                 360                 365             


Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
385                 390                 395                 400 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                405                 410                 415     


Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala 
            420                 425                 430         


Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        435                 440                 445             


Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
465                 470                 475                 480 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met 
            500                 505                 510         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    530                 535                 540                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
545                 550                 555                 560 


Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro 
                565                 570                 575     


Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met 
            580                 585                 590         


Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        595                 600                 605             


Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu 
    610                 615                 620                 


Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg 
625                 630                 635                 640 


Gly Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ala Ala Gln 
                645                 650                 655     


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
            660                 665                 670         


Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala 
        675                 680                 685             


Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly 
    690                 695                 700                 


Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys 
705                 710                 715                 720 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
                725                 730                 735     


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu 
            740                 745                 750         


Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Leu Val 
        755                 760                 765             


Thr Val Ser Ser 
    770         


<210>  217
<211>  786
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody 
       CD16F1-L1-hHS10-L4-hA09-10-3-L3-hA09-10-4-L1-hPL16-L3-hPL16 
       (1518-GS15)

<400>  217

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Val Ser Gly Ser Leu Phe Ser Ala Arg 
            20                  25                  30          


Val Met Gly Trp Tyr Arg Gln Ala Pro Gly Lys Gln Arg Glu Leu Val 
        35                  40                  45              


Ala Ala Ile Thr Ser Gly Val Arg Thr Asp Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Arg Ala Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Val Tyr Tyr Cys Asn 
                85                  90                  95      


Val Asn Leu Tyr Asn Thr Gly Asn Tyr Trp Gly Gln Gly Thr Gln Val 
            100                 105                 110         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Ser Thr Asp Ser Ala Tyr Arg Met Gly 
145                 150                 155                 160 


Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile 
                165                 170                 175     


Asn Trp Ser Asp Gly Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala Asp 
    210                 215                 220                 


Pro Asp Ser Arg Leu Tyr Tyr Thr Val Pro Gln Asn Tyr Asp Tyr Trp 
225                 230                 235                 240 


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser 
            260                 265                 270         


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
        275                 280                 285             


Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala Leu Gly Trp Phe 
    290                 295                 300                 


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala Ala Ile Ser Arg 
305                 310                 315                 320 


Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
                325                 330                 335     


Ile Ser Arg Asp Asn Phe Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
            340                 345                 350         


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ala His Tyr Leu 
        355                 360                 365             


Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met Tyr Asn Tyr Trp 
    370                 375                 380                 


Gly Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln 
385                 390                 395                 400 


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
                405                 410                 415     


Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser Asn Tyr Ala 
            420                 425                 430         


Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val Ala 
        435                 440                 445             


Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp Ser Val Lys 
    450                 455                 460                 


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu 
465                 470                 475                 480 


Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                485                 490                 495     


Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser Thr Asn Met 
            500                 505                 510         


Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly 
        515                 520                 525             


Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Val Glu Ser Gly Gly 
    530                 535                 540                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
545                 550                 555                 560 


Gly Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro 
                565                 570                 575     


Gly Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met 
            580                 585                 590         


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        595                 600                 605             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    610                 615                 620                 


Asp Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala 
625                 630                 635                 640 


Lys Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr 
                645                 650                 655     


Val Ser Ser Ala Ala Ala Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            660                 665                 670         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        675                 680                 685             


Gly Thr Phe Leu Thr Tyr Ser Met Ser Trp Val Arg Gln Ala Pro Gly 
    690                 695                 700                 


Lys Glu Arg Glu Phe Val Ser Ser Ile Asn Trp Ser Gly Tyr Met Thr 
705                 710                 715                 720 


Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                725                 730                 735     


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            740                 745                 750         


Thr Ala Val Tyr Tyr Cys Ala Ala Ala Arg Thr Ala Ile Ala Ala Lys 
        755                 760                 765             


Arg Ser Ser Glu Phe Asp Tyr Trp Gly Gln Gly Thr Gln Val Thr Val 
    770                 775                 780                 


Ser Ser 
785     


<210>  218
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody hHS5-L1-H33-14-L3-H33-14**

<400>  218

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Phe Thr Thr His 
            20                  25                  30          


Ala Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Ala Ile Asn Trp Gly Gly Arg Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Ile Ile Ser Arg Asp Thr Gly Ala Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Asn Leu Asp Thr Tyr Asn Val Arg Ala Gly Thr Thr Asn Ser 
            100                 105                 110         


Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr 
145                 150                 155                 160 


Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu 
                165                 170                 175     


Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr 
            180                 185                 190         


Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys 
        195                 200                 205             


Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu 
                245                 250                 255     


Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu 
            260                 265                 270         


Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp 
        275                 280                 285             


Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp 
    290                 295                 300                 


Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe 
305                 310                 315                 320 


Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser 
                325                 330                 335     


Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu 
            340                 345                 350         


Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        355                 360                 365             


Ser His His His His His His 
    370                 375 


<210>  219
<211>  368
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody FC5-L1-H33-14-L3-H33-14

<400>  219

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser 
145                 150                 155                 160 


Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp 
    290                 295                 300                 


Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
                325                 330                 335     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile 
            340                 345                 350         


Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365             


<210>  220
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody FC5-L1-H33-14-L3-H33-14-L1-hHS5

<400>  220

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
    130                 135                 140                 


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser 
145                 150                 155                 160 


Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg 
                165                 170                 175     


Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser 
            180                 185                 190         


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
        195                 200                 205             


Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val 
    210                 215                 220                 


Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln 
225                 230                 235                 240 


Gly Thr Gln Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val 
                245                 250                 255     


Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
            260                 265                 270         


Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp 
        275                 280                 285             


Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp 
    290                 295                 300                 


Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr 
305                 310                 315                 320 


Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser 
                325                 330                 335     


Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile 
            340                 345                 350         


Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser 
    370                 375                 380                 


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
385                 390                 395                 400 


Ala Ser Gly Arg Thr Phe Thr Thr His Ala Met Gly Trp Phe Arg Gln 
                405                 410                 415     


Ala Pro Gly Lys Glu Arg Glu Phe Val Ser Ala Ile Asn Trp Gly Gly 
            420                 425                 430         


Arg Thr Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Ile Ile Ser 
        435                 440                 445             


Arg Asp Thr Gly Ala Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
    450                 455                 460                 


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Ser Asn Leu Asp Thr Tyr 
465                 470                 475                 480 


Asn Val Arg Ala Gly Thr Thr Asn Ser Trp Gly Gln Gly Thr Gln Val 
                485                 490                 495     


Thr Val Ser Ser 
            500 


<210>  221
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Multispecific antibody H33-14-L3-H33-14

<400>  221

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Arg Thr Ser Leu Ile Leu 
            20                  25                  30          


Ala Met Ala Trp Trp Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Ala 
        35                  40                  45              


Gly Arg Ile Trp Trp Asn Asn Asp Met Thr Arg Tyr Ser Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Glu Ala Asp Leu Ile Gly Gly Ser Arg Gly Trp Gly Gln Gly Thr Gln 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ala Ala Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Arg Thr Ser Leu Ile Leu Ala Met Ala Trp Trp Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Glu Arg Glu Phe Ala Gly Arg Ile Trp Trp Asn Asn Asp 
                165                 170                 175     


Met Thr Arg Tyr Ser Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ala Lys Asn Thr Val Tyr Leu Gln Met Ser Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Glu Ala Asp Leu Ile Gly Gly Ser 
    210                 215                 220                 


Arg Gly Trp Gly Gln Gly Thr Gln Val Thr Val Ser Ser 
225                 230                 235         


<210>  222
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FC5 nanobody

<400>  222

Glu Val Gln Leu Gln Ala Ser Gly Gly Gly Leu Val Gln Ala Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Ile Thr His Tyr 
            20                  25                  30          


Thr Met Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu Phe Val 
        35                  40                  45              


Ser Arg Ile Thr Trp Gly Gly Asp Asn Thr Phe Tyr Ser Asn Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Lys Pro Glu Asp Thr Ala Asp Tyr Tyr Cys 
                85                  90                  95      


Ala Ala Gly Ser Thr Ser Thr Ala Thr Pro Leu Arg Val Asp Tyr Trp 
            100                 105                 110         


Gly Lys Gly Thr Gln Val Thr Val Ser Ser 
        115                 120         


<210>  223
<211>  129
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized hA09-10-30

<400>  223

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Gly Gly Arg Thr Phe Ser 
            20                  25                  30          


Asn Tyr Ala Leu Gly Trp Phe Arg Gln Ala Pro Gly Lys Glu Arg Glu 
        35                  40                  45              


Phe Val Ala Ala Ile Ser Arg Ser Gly Gly Asn Ile Asn Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr 
65                  70                  75                  80  


Val Tyr Leu Gln Met Ser Ser Leu Glu Pro Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Ala His Tyr Leu Leu Leu Pro Ser Tyr Ile Ser Thr Ser 
            100                 105                 110         


Thr Asn Met Tyr Asn Tyr Trp Gly Gln Gly Thr Gln Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  224
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  224

Glu Pro Lys Ser Cys Asp 
1               5       


<210>  225
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  225

Ala Ser Thr Lys Gly Pro 
1               5       


