                         SEQUENCE LISTING

<110>  CODIAK BIOSCIENCES, INC.
 
<120>  METHODS OF PRODUCING EXTRACELLULAR VESICLES

<130>  4000.068PC03

<150>  US 62/906,023
<151>  2019-09-25

<150>  US 63/059,754
<151>  2020-07-31

<150>  US 63/066,654
<151>  2020-08-17

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  879
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The PTGFRN Protein

<400>  1

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro Thr Ala Thr Leu Val 
            20                  25                  30          


Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys Asn Val Ser Asp Tyr 
        35                  40                  45              


Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser Phe Ser Ser Leu Gly 
    50                  55                  60                  


Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu Val Gly Phe Pro Ala 
65                  70                  75                  80  


Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu Ile Leu Leu Arg Arg 
                85                  90                  95      


Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys Asn Val Gln Pro Ser 
            100                 105                 110         


Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser Thr Asp Ala Thr Val 
        115                 120                 125             


Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys Val Leu Ala Asp Ser 
    130                 135                 140                 


Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg 
145                 150                 155                 160 


Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro 
                165                 170                 175     


Leu His Thr His Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala 
            180                 185                 190         


Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly 
        195                 200                 205             


Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr 
    210                 215                 220                 


Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala 
225                 230                 235                 240 


Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln 
                245                 250                 255     


Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val 
            260                 265                 270         


Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser 
        275                 280                 285             


Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp 
    290                 295                 300                 


Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met 
305                 310                 315                 320 


Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg 
                325                 330                 335     


Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu Ser His Val Asp 
            340                 345                 350         


Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser 
        355                 360                 365             


Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg 
    370                 375                 380                 


Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly 
385                 390                 395                 400 


Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys 
                405                 410                 415     


Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val 
            420                 425                 430         


Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr 
        435                 440                 445             


Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu 
    450                 455                 460                 


Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys 
465                 470                 475                 480 


Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp 
                485                 490                 495     


Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn 
            500                 505                 510         


Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp 
        515                 520                 525             


Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala 
    530                 535                 540                 


Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe 
545                 550                 555                 560 


Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys 
                565                 570                 575     


Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro 
            580                 585                 590         


Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu 
        595                 600                 605             


Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg 
    610                 615                 620                 


Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr 
625                 630                 635                 640 


Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met 
                645                 650                 655     


Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala 
            660                 665                 670         


Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro 
        675                 680                 685             


Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly 
    690                 695                 700                 


Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu 
705                 710                 715                 720 


Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser 
                725                 730                 735     


Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys 
            740                 745                 750         


Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu 
        755                 760                 765             


Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu 
    770                 775                 780                 


Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys 
785                 790                 795                 800 


Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro 
                805                 810                 815     


Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro 
            820                 825                 830         


Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys 
        835                 840                 845             


Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln 
    850                 855                 860                 


Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
865                 870                 875                 


<210>  2
<211>  192
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  The PTGFRN protein Fragment

<400>  2

Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser Val Ile 
1               5                   10                  15      


Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu Gly Ala 
            20                  25                  30          


Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe Ala Val 
        35                  40                  45              


His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser Leu Asp 
    50                  55                  60                  


Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu 
65                  70                  75                  80  


Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val His Gly 
                85                  90                  95      


Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp 
            100                 105                 110         


Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile His Ser 
        115                 120                 125             


Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe Lys 
    130                 135                 140                 


Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu Leu 
145                 150                 155                 160 


Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys Glu 
                165                 170                 175     


Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu Met 
            180                 185                 190         


<210>  3
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #1

<400>  3

Pro Ser Ala Arg Pro Pro Pro Ser Leu Ser Leu Arg Glu Gly Glu Pro 
1               5                   10                  15      


Phe Glu Leu Arg Cys Thr Ala Ala Ser Ala Ser Pro Leu His Thr His 
            20                  25                  30          


Leu Ala Leu Leu Trp Glu Val His Arg Gly Pro Ala Arg Arg Ser Val 
        35                  40                  45              


Leu Ala Leu Thr His Glu Gly Arg Phe His Pro Gly Leu Gly Tyr Glu 
    50                  55                  60                  


Gln Arg Tyr His Ser Gly Asp Val Arg Leu Asp Thr Val Gly Ser Asp 
65                  70                  75                  80  


Ala Tyr Arg Leu Ser Val Ser Arg Ala Leu Ser Ala Asp Gln Gly Ser 
                85                  90                  95      


Tyr Arg Cys Ile Val Ser Glu Trp Ile Ala Glu Gln Gly Asn Trp Gln 
            100                 105                 110         


Glu Ile Gln Glu Lys Ala Val Glu Val Ala Thr Val Val Ile Gln Pro 
        115                 120                 125             


Ser Val Leu Arg Ala Ala Val Pro Lys Asn Val Ser Val Ala Glu Gly 
    130                 135                 140                 


Lys Glu Leu Asp Leu Thr Cys Asn Ile Thr Thr Asp Arg Ala Asp Asp 
145                 150                 155                 160 


Val Arg Pro Glu Val Thr Trp Ser Phe Ser Arg Met Pro Asp Ser Thr 
                165                 170                 175     


Leu Pro Gly Ser Arg Val Leu Ala Arg Leu Asp Arg Asp Ser Leu Val 
            180                 185                 190         


His Ser Ser Pro His Val Ala Leu Ser His Val Asp Ala Arg Ser Tyr 
        195                 200                 205             


His Leu Leu Val Arg Asp Val Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr 
    210                 215                 220                 


Cys His Val Ser Leu Trp Ala Pro Gly His Asn Arg Ser Trp His Lys 
225                 230                 235                 240 


Val Ala Glu Ala Val Ser Ser Pro Ala Gly Val Gly Val Thr Trp Leu 
                245                 250                 255     


Glu Pro Asp Tyr Gln Val Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe 
            260                 265                 270         


Ala Asp Asp Pro Thr Glu Leu Ala Cys Arg Val Val Asp Thr Lys Ser 
        275                 280                 285             


Gly Glu Ala Asn Val Arg Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn 
    290                 295                 300                 


Arg Arg Ser Asp Asn Val Val Thr Ser Glu Leu Leu Ala Val Met Asp 
305                 310                 315                 320 


Gly Asp Trp Thr Leu Lys Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln 
                325                 330                 335     


Asp Gly Asp Phe Ile Phe Ser Lys Glu His Thr Asp Thr Phe Asn Phe 
            340                 345                 350         


Arg Ile Gln Arg Thr Thr Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val 
        355                 360                 365             


Val Ser Ala Trp Thr Lys Gln Arg Asn Asn Ser Trp Val Lys Ser Lys 
    370                 375                 380                 


Asp Val Phe Ser Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser 
385                 390                 395                 400 


Val Leu Val Val Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly 
                405                 410                 415     


Asn Thr Phe Glu Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser 
            420                 425                 430         


Pro Arg Tyr Ser Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu 
        435                 440                 445             


Ser Ser Pro Asn Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser 
    450                 455                 460                 


Val Val Lys Leu Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val 
465                 470                 475                 480 


Val Leu Glu Lys Val Gln Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln 
                485                 490                 495     


Thr Gln Val Ser Asp Ala Gly Leu Tyr Arg Cys Met Val Thr Ala Trp 
            500                 505                 510         


Ser Pro Val Arg Gly Ser Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser 
        515                 520                 525             


Asn Pro Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala 
    530                 535                 540                 


Ser Val His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys 
545                 550                 555                 560 


Leu Phe Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp 
                565                 570                 575     


Met Ala Phe Asp Val Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp 
            580                 585                 590         


Lys Ala Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr 
        595                 600                 605             


Thr Ser Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser 
    610                 615                 620                 


Val Leu Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe 
625                 630                 635                 640 


Gly Asn Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly 
                645                 650                 655     


Ser Trp Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr 
            660                 665                 670         


Val Lys Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly 
        675                 680                 685             


Val Gly Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr 
    690                 695                 700                 


Cys Ser Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg 
705                 710                 715                 720 


Glu Arg Arg Arg Leu Met Ser Met Glu Met Asp 
                725                 730     


<210>  4
<211>  611
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #2

<400>  4

Val Ala Thr Val Val Ile Gln Pro Ser Val Leu Arg Ala Ala Val Pro 
1               5                   10                  15      


Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys Asn 
            20                  25                  30          


Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp Ser 
        35                  40                  45              


Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu Ala 
    50                  55                  60                  


Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val Ala Leu 
65                  70                  75                  80  


Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val Ser 
                85                  90                  95      


Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala Pro 
            100                 105                 110         


Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser Ser Pro 
        115                 120                 125             


Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr Leu 
    130                 135                 140                 


Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu Ala 
145                 150                 155                 160 


Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe Thr 
                165                 170                 175     


Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val Thr 
            180                 185                 190         


Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr Gly 
        195                 200                 205             


Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser Lys 
    210                 215                 220                 


Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu Glu 
225                 230                 235                 240 


Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln Arg 
                245                 250                 255     


Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val Asn 
            260                 265                 270         


Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg Gln 
        275                 280                 285             


Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys Lys 
    290                 295                 300                 


Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile Met 
305                 310                 315                 320 


Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys Tyr 
                325                 330                 335     


Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp Thr 
            340                 345                 350         


Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys Val Gln Glu Asp 
        355                 360                 365             


Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly Leu 
    370                 375                 380                 


Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu Trp 
385                 390                 395                 400 


Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe Gln 
                405                 410                 415     


Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro Ser 
            420                 425                 430         


Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val Glu 
        435                 440                 445             


Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp Phe 
    450                 455                 460                 


Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser Ser 
465                 470                 475                 480 


Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys Ser 
                485                 490                 495     


Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln Val 
            500                 505                 510         


His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val Thr 
        515                 520                 525             


Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu Ile 
    530                 535                 540                 


His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala 
545                 550                 555                 560 


Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly 
                565                 570                 575     


Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys 
            580                 585                 590         


Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met 
        595                 600                 605             


Glu Met Asp 
    610     


<210>  5
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #3

<400>  5

Ser Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val 
1               5                   10                  15      


Tyr Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu 
            20                  25                  30          


Leu Ala Cys Arg Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg 
        35                  40                  45              


Phe Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val 
    50                  55                  60                  


Val Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys 
65                  70                  75                  80  


Tyr Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe 
                85                  90                  95      


Ser Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr 
            100                 105                 110         


Glu Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys 
        115                 120                 125             


Gln Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser Lys Pro 
    130                 135                 140                 


Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val Lys Ala 
145                 150                 155                 160 


Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu Met Thr 
                165                 170                 175     


Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu 
            180                 185                 190         


Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn Glu Thr 
        195                 200                 205             


Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu Glu Asn 
    210                 215                 220                 


Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys Val Gln 
225                 230                 235                 240 


Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser Asp Ala 
                245                 250                 255     


Gly Leu Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg Gly Ser 
            260                 265                 270         


Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp 
        275                 280                 285             


Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr 
    290                 295                 300                 


Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr 
305                 310                 315                 320 


Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser 
                325                 330                 335     


Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu 
            340                 345                 350         


Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp 
        355                 360                 365             


Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu 
    370                 375                 380                 


Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser 
385                 390                 395                 400 


Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala 
                405                 410                 415     


Glu Ile His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu 
            420                 425                 430         


Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val 
        435                 440                 445             


Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys 
    450                 455                 460                 


Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met 
465                 470                 475                 480 


Ser Met Glu Met Asp 
                485 


<210>  6
<211>  343
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #4

<400>  6

Lys Pro Val Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val 
1               5                   10                  15      


Lys Ala Arg Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu 
            20                  25                  30          


Met Thr Cys Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser 
        35                  40                  45              


Val Leu Ile Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn 
    50                  55                  60                  


Glu Thr Lys Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu 
65                  70                  75                  80  


Glu Asn Trp Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys 
                85                  90                  95      


Val Gln Glu Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser 
            100                 105                 110         


Asp Ala Gly Leu Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg 
        115                 120                 125             


Gly Ser Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu 
    130                 135                 140                 


Ile Asp Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser 
145                 150                 155                 160 


Asp Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile 
                165                 170                 175     


Ile Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp 
            180                 185                 190         


Val Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val 
        195                 200                 205             


Leu Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg 
    210                 215                 220                 


Asp Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe 
225                 230                 235                 240 


Leu Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr 
                245                 250                 255     


Cys Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys 
            260                 265                 270         


Glu Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp 
        275                 280                 285             


Val Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser 
    290                 295                 300                 


Thr Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His 
305                 310                 315                 320 


Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg 
                325                 330                 335     


Leu Met Ser Met Glu Met Asp 
            340             


<210>  7
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #5

<400>  7

Val Arg Gly Ser Leu Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro 
1               5                   10                  15      


Ile Glu Ile Asp Phe Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val 
            20                  25                  30          


His Ser Asp Thr Pro Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe 
        35                  40                  45              


Cys Ile Ile Thr Val Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala 
    50                  55                  60                  


Phe Asp Val Ser Trp Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala 
65                  70                  75                  80  


Pro Val Leu Leu Ser Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser 
                85                  90                  95      


Arg Arg Asp Trp Lys Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu 
            100                 105                 110         


Glu Phe Leu Leu Gln Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn 
        115                 120                 125             


Tyr Tyr Cys Ser Val Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp 
    130                 135                 140                 


Gln Lys Glu Ala Glu Ile His Ser Lys Pro Val Phe Ile Thr Val Lys 
145                 150                 155                 160 


Met Asp Val Leu Asn Ala Phe Lys Tyr Pro Leu Leu Ile Gly Val Gly 
                165                 170                 175     


Leu Ser Thr Val Ile Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser 
            180                 185                 190         


Ser His Trp Cys Cys Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg 
        195                 200                 205             


Arg Arg Leu Met Ser Met Glu Met Asp 
    210                 215         


<210>  8
<211>  66
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein Fragment #6

<400>  8

Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn Ala Phe 
1               5                   10                  15      


Lys Tyr Pro Leu Leu Ile Gly Val Gly Leu Ser Thr Val Ile Gly Leu 
            20                  25                  30          


Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys Lys Lys 
        35                  40                  45              


Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser Met Glu 
    50                  55                  60                  


Met Asp 
65      


<210>  9
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PTGFRN Protein - Signal Peptide

<400>  9

Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu Ala Leu Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Arg Gly 
            20      


