                         SEQUENCE LISTING

<110>  FATE THERAPEUTICS, INC.
 
<120>  MULTI-TARGETING EFFECTOR CELLS AND USE THEREOF

<130>  056932-519001WO

<160>  48    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD58 Exon 1 knockout (CD58-gNA-1)

<400>  1
gaccacgctg aggaccccca                                                   20


<210>  2
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD58 Exon 1 knockout (CD58-gNA-2)

<400>  2
tggttgctgg gagcgacgcg                                                   20


<210>  3
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD58 Exon 1 knockout (CD58-gNA-3)

<400>  3
catggttgct gggagcgacg                                                   20


<210>  4
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD54 Exon 1 knockout (CD54-gNA-1)

<400>  4
cccgagcagg accaggagtg                                                   20


<210>  5
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD54 Exon 1 knockout (CD54-gNA-2)

<400>  5
cgcactcctg gtcctgctcg                                                   20


<210>  6
<211>  20
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  targeting sequence for CD54 Exon 1 knockout (CD54-gNA-3)

<400>  6
ctgggaacag agccccgagc                                                   20


<210>  7
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  340 a.a. CD64 domain-based construction

<400>  7

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Gln Leu Pro Thr Pro 
        275                 280                 285             


Val Trp Phe His Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu 
    290                 295                 300                 


Phe Ala Val Asp Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg 
305                 310                 315                 320 


Ser Ser Thr Arg Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp 
                325                 330                 335     


Pro Gln Asp Lys 
            340 


<210>  8
<211>  336
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  336 a.a. CD64 exon-based construction

<400>  8

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Leu Phe Phe Pro Pro Gly 
        275                 280                 285             


Tyr Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp 
    290                 295                 300                 


Thr Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg 
305                 310                 315                 320 


Asp Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335     


<210>  9
<211>  335
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  335 a.a. CD64 exon-based construction

<400>  9

Met Trp Phe Leu Thr Thr Leu Leu Leu Trp Val Pro Val Asp Gly Gln 
1               5                   10                  15      


Val Asp Thr Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser 
            20                  25                  30          


Val Phe Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu 
        35                  40                  45              


Pro Gly Ser Ser Ser Thr Gln Trp Phe Leu Asn Gly Thr Ala Thr Gln 
    50                  55                  60                  


Thr Ser Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn Asp Ser 
65                  70                  75                  80  


Gly Glu Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg Ser Asp Pro Ile 
                85                  90                  95      


Gln Leu Glu Ile His Arg Gly Trp Leu Leu Leu Gln Val Ser Ser Arg 
            100                 105                 110         


Val Phe Thr Glu Gly Glu Pro Leu Ala Leu Arg Cys His Ala Trp Lys 
        115                 120                 125             


Asp Lys Leu Val Tyr Asn Val Leu Tyr Tyr Arg Asn Gly Lys Ala Phe 
    130                 135                 140                 


Lys Phe Phe His Trp Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile 
145                 150                 155                 160 


Ser His Asn Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr 
                165                 170                 175     


Thr Ser Ala Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro 
            180                 185                 190         


Val Leu Asn Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu Val 
        195                 200                 205             


Thr Leu Ser Cys Glu Thr Lys Leu Leu Leu Gln Arg Pro Gly Leu Gln 
    210                 215                 220                 


Leu Tyr Phe Ser Phe Tyr Met Gly Ser Lys Thr Leu Arg Gly Arg Asn 
225                 230                 235                 240 


Thr Ser Ser Glu Tyr Gln Ile Leu Thr Ala Arg Arg Glu Asp Ser Gly 
                245                 250                 255     


Leu Tyr Trp Cys Glu Ala Ala Thr Glu Asp Gly Asn Val Leu Lys Arg 
            260                 265                 270         


Ser Pro Glu Leu Glu Leu Gln Val Leu Gly Phe Phe Pro Pro Gly Tyr 
        275                 280                 285             


Gln Val Ser Phe Cys Leu Val Met Val Leu Leu Phe Ala Val Asp Thr 
    290                 295                 300                 


Gly Leu Tyr Phe Ser Val Lys Thr Asn Ile Arg Ser Ser Thr Arg Asp 
305                 310                 315                 320 


Trp Lys Asp His Lys Phe Lys Trp Arg Lys Asp Pro Gln Asp Lys 
                325                 330                 335 


<210>  10
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  exemplifying sequence encoding 340 a.a. CD64 domain-based 
       construction

<400>  10
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggcct ccagttacca actcctgtct ggtttcatta ccaagtctct      900

ttctgcttgg tgatggtact cctttttgca gtggacacag gactatattt ctctgtgaag      960

acaaacattc gaagctcaac aagagactgg aaggaccata aatttaaatg gagaaaggac     1020

cctcaagaca aa                                                         1032


<210>  11
<211>  1020
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  exemplifying sequence encoding 336 a.a. CD64 exon-based 
       construction

<400>  11
cttggagaca acatgtggtt cttgacaact ctgctccttt gggttccagt tgatgggcaa       60

gtggacacca caaaggcagt gatcactttg cagcctccat gggtcagcgt gttccaagag      120

gaaaccgtaa ccttgcattg tgaggtgctc catctgcctg ggagcagctc tacacagtgg      180

tttctcaatg gcacagccac tcagacctcg acccccagct acagaatcac ctctgccagt      240

gtcaatgaca gtggtgaata caggtgccag agaggtctct cagggcgaag tgaccccata      300

cagctggaaa tccacagagg ctggctacta ctgcaggtct ccagcagagt cttcacggaa      360

ggagaacctc tggccttgag gtgtcatgcg tggaaggata agctggtgta caatgtgctt      420

tactatcgaa atggcaaagc ctttaagttt ttccactgga attctaacct caccattctg      480

aaaaccaaca taagtcacaa tggcacctac cattgctcag gcatgggaaa gcatcgctac      540

acatcagcag gaatatctgt cactgtgaaa gagctatttc cagctccagt gctgaatgca      600

tctgtgacat ccccactcct ggaggggaat ctggtcaccc tgagctgtga aacaaagttg      660

ctcttgcaga ggcctggttt gcagctttac ttctccttct acatgggcag caagaccctg      720

cgaggcagga acacatcctc tgaataccaa atactaactg ctagaagaga agactctggg      780

ttatactggt gcgaggctgc cacagaggat ggaaatgtcc ttaagcgcag ccctgagttg      840

gagcttcaag tgcttggttt gttctttcca cctgggtacc aagtctcttt ctgcttggtg      900

atggtactcc tttttgcagt ggacacagga ctatatttct ctgtgaagac aaacattcga      960

agctcaacaa gagactggaa ggaccataaa tttaaatgga gaaaggaccc tcaagacaaa     1020


<210>  12
<211>  1005
<212>  DNA
<213>  ARTIFICIAL SEQUENCE

<220>
<223>  exemplifying sequence encoding 335 a.a. CD64 exon-based 
       construction

<400>  12
atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca       60

aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc      120

ttgcactgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc      180

acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt      240

ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc      300

cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg      360

gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat      420

ggcaaagcct ttaagttttt ccactggaac tctaacctca ccattctgaa aaccaacata      480

agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga      540

atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc      600

ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg      660

cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac      720

acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc      780

gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg      840

cttggcttct ttccacctgg gtaccaagtc tctttctgct tggtgatggt actccttttt      900

gcagtggaca caggactata tttctctgtg aagacaaaca ttcgaagctc aacaagagac      960

tggaaggacc ataaatttaa atggagaaag gaccctcaag acaaa                     1005


<210>  13
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  153 a.a. CD28 co-stim + CD3-zeta-ITAM

<400>  13

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser Arg Ser 
        35                  40                  45              


Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu 
    50                  55                  60                  


Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg 
65                  70                  75                  80  


Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln 
                85                  90                  95      


Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Phe 
            100                 105                 110         


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
        115                 120                 125             


Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe Asp Ala 
    130                 135                 140                 


Leu His Met Gln Ala Leu Pro Pro Arg 
145                 150             


<210>  14
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  219 a.a. CD28 hinge + CD28 TM + CD28 co-stim + CD3-zeta-ITAM

<400>  14

Ile Glu Val Met Tyr Pro Pro Pro Tyr Leu Asp Asn Glu Lys Ser Asn 
1               5                   10                  15      


Gly Thr Ile Ile His Val Lys Gly Lys His Leu Cys Pro Ser Pro Leu 
            20                  25                  30          


Phe Pro Gly Pro Ser Lys Pro Phe Trp Val Leu Val Val Val Gly Gly 
        35                  40                  45              


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
    50                  55                  60                  


Trp Val Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn 
65                  70                  75                  80  


Met Thr Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr 
                85                  90                  95      


Ala Pro Pro Arg Asp Phe Ala Ala Tyr Arg Ser Arg Val Lys Phe Ser 
            100                 105                 110         


Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr 
        115                 120                 125             


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
    130                 135                 140                 


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
145                 150                 155                 160 


Pro Gln Glu Gly Leu Phe Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
                165                 170                 175     


Ala Phe Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
            180                 185                 190         


His Asp Gly Leu Phe Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Phe 
        195                 200                 205             


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
    210                 215                 


<210>  15
<211>  263
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  263 a.a NKG2D TM + 2B4 + CD3-zeta

<400>  15

Ser Asn Leu Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg 
1               5                   10                  15      


Ile Gly Met Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp 
            20                  25                  30          


Arg Arg Lys Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe 
        35                  40                  45              


Leu Thr Ile Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His 
    50                  55                  60                  


Glu Gln Glu Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met 
65                  70                  75                  80  


Ile Gln Ser Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr 
                85                  90                  95      


Leu Tyr Ser Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg 
            100                 105                 110         


Asn His Ser Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys 
        115                 120                 125             


Ser Gln Pro Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu 
    130                 135                 140                 


Glu Asn Phe Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp 
145                 150                 155                 160 


Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn 
                165                 170                 175     


Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg 
            180                 185                 190         


Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly 
        195                 200                 205             


Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu 
    210                 215                 220                 


Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu 
225                 230                 235                 240 


Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His 
                245                 250                 255     


Met Gln Ala Leu Pro Pro Arg 
            260             


<210>  16
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  308 a.a CD8 hinge + NKG2D TM + 2B4 + CD3-zeta

<400>  16

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp Ser Asn Leu 
        35                  40                  45              


Phe Val Ala Ser Trp Ile Ala Val Met Ile Ile Phe Arg Ile Gly Met 
    50                  55                  60                  


Ala Val Ala Ile Phe Cys Cys Phe Phe Phe Pro Ser Trp Arg Arg Lys 
65                  70                  75                  80  


Arg Lys Glu Lys Gln Ser Glu Thr Ser Pro Lys Glu Phe Leu Thr Ile 
                85                  90                  95      


Tyr Glu Asp Val Lys Asp Leu Lys Thr Arg Arg Asn His Glu Gln Glu 
            100                 105                 110         


Gln Thr Phe Pro Gly Gly Gly Ser Thr Ile Tyr Ser Met Ile Gln Ser 
        115                 120                 125             


Gln Ser Ser Ala Pro Thr Ser Gln Glu Pro Ala Tyr Thr Leu Tyr Ser 
    130                 135                 140                 


Leu Ile Gln Pro Ser Arg Lys Ser Gly Ser Arg Lys Arg Asn His Ser 
145                 150                 155                 160 


Pro Ser Phe Asn Ser Thr Ile Tyr Glu Val Ile Gly Lys Ser Gln Pro 
                165                 170                 175     


Lys Ala Gln Asn Pro Ala Arg Leu Ser Arg Lys Glu Leu Glu Asn Phe 
            180                 185                 190         


Asp Val Tyr Ser Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala 
        195                 200                 205             


Tyr Lys Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg 
    210                 215                 220                 


Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu 
225                 230                 235                 240 


Met Gly Gly Lys Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn 
                245                 250                 255     


Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met 
            260                 265                 270         


Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly 
        275                 280                 285             


Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala 
    290                 295                 300                 


Leu Pro Pro Arg 
305             


<210>  17
<211>  379
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  construct mimicking trans-presentation of IL15 (design 3)

<400>  17

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
                245                 250                 255     


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
            260                 265                 270         


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
        275                 280                 285             


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
    290                 295                 300                 


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
305                 310                 315                 320 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
                325                 330                 335     


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
            340                 345                 350         


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
        355                 360                 365             


Ser Leu Leu Ala Cys Tyr Leu Lys Ser Arg Gln 
    370                 375                 


<210>  18
<211>  1140
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary nucleic acid sequence encoding construct mimicking 
       trans-presentation of IL15 (design 3)

<400>  18
atggactgga cctggattct gttcctggtc gcggctgcaa cgcgagtcca tagcggtatc       60

catgttttta ttcttgggtg tttttctgct gggctgccta agaccgaggc caactgggta      120

aatgtcatca gtgacctcaa gaaaatagaa gaccttatac aaagcatgca cattgatgct      180

actctctaca ctgagtcaga tgtacatccc tcatgcaaag tgacggccat gaaatgtttc      240

ctcctcgaac ttcaagtcat atctctggaa agtggcgacg cgtccatcca cgacacggtc      300

gaaaacctga taatactcgc taataatagt ctctcttcaa atggtaacgt aaccgagtca      360

ggttgcaaag agtgcgaaga gttggaagaa aaaaacataa aggagttcct gcaaagtttc      420

gtgcacattg tgcagatgtt cattaatacc tctagcggcg gaggatcagg tggcggtgga      480

agcggaggtg gaggctccgg tggaggaggt agtggcggag gttctcttca aataacttgt      540

cctccaccga tgtccgtaga acatgcggat atttgggtaa aatcctatag cttgtacagc      600

cgagagcggt atatctgcaa cagcggcttc aagcggaagg ccggcacaag cagcctgacc      660

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccctag cctgaagtgc      720

atcagagatc ccgccctggt gcatcagcgg cctgcccctc caagcacagt gacaacagct      780

ggcgtgaccc cccagcctga gagcctgagc ccttctggaa aagagcctgc cgccagcagc      840

cccagcagca acaatactgc cgccaccaca gccgccatcg tgcctggatc tcagctgatg      900

cccagcaaga gccctagcac cggcaccacc gagatcagca gccacgagtc tagccacggc      960

accccatctc agaccaccgc caagaactgg gagctgacag ccagcgcctc tcaccagcct     1020

ccaggcgtgt accctcaggg ccacagcgat accacagtgg ccatcagcac ctccaccgtg     1080

ctgctgtgtg gactgagcgc cgtgtcactg ctggcctgct acctgaagtc cagacagtga     1140


<210>  19
<211>  242
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  fused IL15/mb-Sushi construct (design 4)

<400>  19

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg 
        


<210>  20
<211>  726
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  an exemplary nucleic acid sequence encoding fused IL15/mb-Sushi 
       construct (design 4)

<400>  20
atggactgga cctggattct gttcctggtc gcggctgcaa cgcgagtcca tagcggtatc       60

catgttttta ttcttgggtg tttttctgct gggctgccta agaccgaggc caactgggta      120

aatgtcatca gtgacctcaa gaaaatagaa gaccttatac aaagcatgca cattgatgct      180

actctctaca ctgagtcaga tgtacatccc tcatgcaaag tgacggccat gaaatgtttc      240

ctcctcgaac ttcaagtcat atctctggaa agtggcgacg cgtccatcca cgacacggtc      300

gaaaacctga taatactcgc taataatagt ctctcttcaa atggtaacgt aaccgagtca      360

ggttgcaaag agtgcgaaga gttggaagaa aaaaacataa aggagttcct gcaaagtttc      420

gtgcacattg tgcagatgtt cattaatacc tctagcggcg gaggatcagg tggcggtgga      480

agcggaggtg gaggctccgg tggaggaggt agtggcggag gttctcttca aataacttgt      540

cctccaccga tgtccgtaga acatgcggat atttgggtaa aatcctatag cttgtacagc      600

cgagagcggt atatctgcaa cagcggcttc aagcggaagg ccggcacaag cagcctgacc      660

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccctag cctgaagtgc      720

atcaga                                                                 726


<210>  21
<211>  375
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  protein construct further modified from SEQ ID NO. 17

<400>  21

Met Asp Trp Thr Trp Ile Leu Phe Leu Val Ala Ala Ala Thr Arg Val 
1               5                   10                  15      


His Ser Gly Ile His Val Phe Ile Leu Gly Cys Phe Ser Ala Gly Leu 
            20                  25                  30          


Pro Lys Thr Glu Ala Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys 
        35                  40                  45              


Ile Glu Asp Leu Ile Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr 
    50                  55                  60                  


Glu Ser Asp Val His Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe 
65                  70                  75                  80  


Leu Leu Glu Leu Gln Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile 
                85                  90                  95      


His Asp Thr Val Glu Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser 
            100                 105                 110         


Ser Asn Gly Asn Val Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu 
        115                 120                 125             


Glu Glu Lys Asn Ile Lys Glu Phe Leu Gln Ser Phe Val His Ile Val 
    130                 135                 140                 


Gln Met Phe Ile Asn Thr Ser Ser Gly Gly Gly Ser Gly Gly Gly Gly 
145                 150                 155                 160 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Leu 
                165                 170                 175     


Gln Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile Trp 
            180                 185                 190         


Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn Ser 
        195                 200                 205             


Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val Leu 
    210                 215                 220                 


Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys Cys 
225                 230                 235                 240 


Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser Thr 
                245                 250                 255     


Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro Ser 
            260                 265                 270         


Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala Ala 
        275                 280                 285             


Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys Ser 
    290                 295                 300                 


Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His Gly 
305                 310                 315                 320 


Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser Ala 
                325                 330                 335     


Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly His Ser Asp Thr Thr 
            340                 345                 350         


Val Ala Ile Ser Thr Ser Thr Val Leu Leu Cys Gly Leu Ser Ala Val 
        355                 360                 365             


Ser Leu Leu Ala Cys Tyr Leu 
    370                 375 


<210>  22
<211>  601
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LHA/CD38

<400>  22
cagagggcat tgtgtgcaca cacgtataga agcaggcagc ccaccctcat gctttccagg       60

aagcaaatgt ggctcaggtg taaagtgccc ggttgatgaa gggagttagc ggagggagta      120

taaggatgta ctgtctgccc ccttaggaca cctgcagagg attaaggtgg ctgtttctcc      180

ctggaggtgg agtgggtggg tcactgcaca ggagcctata gttgttggtc ttttaaactc      240

ttattggtgt aaccagccac ggaactctga ggcaaggggt tgggggtggg aagggaaaca      300

gagaaaaggc aagtgaaaca gaaggggagg tgcagtttca gaacccagcc agcctctctc      360

ttgctgccta gcctcctgcc ggcctcatct tcgcccagcc aaccccgcct ggagccctat      420

ggccaactgc gagttcagcc cggtgtccgg ggacaaaccc tgctgccggc tctctaggag      480

agcccaactc tgtcttggcg tcagtatcct ggtcctgatc ctcgtcgtgg tgctcgcggt      540

ggtcgtcccg aggtggcgcc agcagtggag cggtccgggc accaccaagc gctttcccga      600

g                                                                      601


<210>  23
<211>  252
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  insol

<400>  23
tcagcctaaa gctttttccc cgtatccccc caggtgtctg caggctcaaa gagcagcgag       60

aagcgttcag aggaaagcga tcccgtgcca ccttccccgt gcccgggctg tccccgcacg      120

ctgccggctc ggggatgcgg ggggagcgcc ggaccggagc ggagccccgg gcggctcgct      180

gctgccccct agcgggggag ggacgtaatt acatccctgg gggctttggg ggggggctgt      240

ccccgtgagc tc                                                          252


<210>  24
<211>  1734
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  CAG

<400>  24
gttgacattg attattgact agttattaat agtaatcaat tacggggtca ttagttcata       60

gcccatatat ggagttccgc gttacataac ttacggtaaa tggcccgcct ggctgaccgc      120

ccaacgaccc ccgcccattg acgtcaataa tgacgtatgt tcccatagta acgccaatag      180

ggactttcca ttgacgtcaa tgggtggagt atttacggta aactgcccac ttggcagtac      240

atcaagtgta tcatatgcca agtacgcccc ctattgacgt caatgacggt aaatggcccg      300

cctggcatta tgcccagtac atgaccttat gggactttcc tacttggcag tacatctacg      360

tattagtcat cgctattacc atggtcgagg tgagccccac gttctgcttc actctcccca      420

tctccccccc ctccccaccc ccaattttgt atttatttat tttttaatta ttttgtgcag      480

cgatgggggc gggggggggg ggggggcgcg cgccaggcgg ggcggggcgg ggcgaggggc      540

ggggcggggc gaggcggaga ggtgcggcgg cagccaatca gagcggcgcg ctccgaaagt      600

ttccttttat ggcgaggcgg cggcggcggc ggccctataa aaagcgaagc gcgcggcggg      660

cggggagtcg ctgcgacgct gccttcgccc cgtgccccgc tccgccgccg cctcgcgccg      720

cccgccccgg ctctgactga ccgcgttact cccacaggtg agcgggcggg acggcccttc      780

tcctccgggc tgtaattagc gcttggttta atgacggctt gtttcttttc tgtggctgcg      840

tgaaagcctt gaggggctcc gggagggccc tttgtgcggg gggagcggct cggggggtgc      900

gtgcgtgtgt gtgtgcgtgg ggagcgccgc gtgcggctcc gcgctgcccg gcggctgtga      960

gcgctgcggg cgcggcgcgg ggctttgtgc gctccgcagt gtgcgcgagg ggagcgcggc     1020

cgggggcggt gccccgcggt gcgggggggg ctgcgagggg aacaaaggct gcgtgcgggg     1080

tgtgtgcgtg ggggggtgag cagggggtgt gggcgcgtcg gtcgggctgc aaccccccct     1140

gcacccccct ccccgagttg ctgagcacgg cccggcttcg ggtgcggggc tccgtacggg     1200

gcgtggcgcg gggctcgccg tgccgggcgg ggggtggcgg caggtggggg tgccgggcgg     1260

ggcggggccg cctcgggccg gggagggctc gggggagggg cgcggcggcc cccggagcgc     1320

cggcggctgt cgaggcgcgg cgagccgcag ccattgcctt ttatggtaat cgtgcgagag     1380

ggcgcaggga cttcctttgt cccaaatctg tgcggagccg aaatctggga ggcgccgccg     1440

caccccctct agcgggcgcg gggcgaagcg gtgcggcgcc ggcaggaagg aaatgggcgg     1500

ggagggcctt cgtgcgtcgc cgcgccgccg tccccttctc cctctccagc ctcggggctg     1560

tccgcggggg gacggctgcc ttcggggggg acggggcagg gcggggttcg gcttctggcg     1620

tgtgaccggc ggctctagag cctctgctaa ccatgttcat gccttcttct ttttcctaca     1680

gctcctgggc aacgtgctgg ttattgtgct gtctcatcat tttggcaaag aatt           1734


<210>  25
<211>  1137
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IL15RF(tr)

<400>  25
atggactgga cctggattct gttcctggtc gcggctgcaa cgcgagtcca tagcggtatc       60

catgttttta ttcttgggtg tttttctgct gggctgccta agaccgaggc caactgggta      120

aatgtcatca gtgacctcaa gaaaatagaa gaccttatac aaagcatgca cattgatgct      180

actctctaca ctgagtcaga tgtacatccc tcatgcaaag tgacggccat gaaatgtttc      240

ctcctcgaac ttcaagtcat atctctggaa agtggcgacg cgtccatcca cgacacggtc      300

gaaaacctga taatactcgc taataatagt ctctcttcaa atggtaacgt aaccgagtca      360

ggttgcaaag agtgcgaaga gttggaagaa aaaaacataa aggagttcct gcaaagtttc      420

gtgcacattg tgcagatgtt cattaatacc tctagcggcg gaggatcagg tggcggtgga      480

agcggaggtg gaggctccgg tggaggaggt agtggcggag gttctcttca aataacttgt      540

cctccaccga tgtccgtaga acatgcggat atttgggtaa aatcctatag cttgtacagc      600

cgagagcggt atatctgcaa cagcggcttc aagcggaagg ccggcacaag cagcctgacc      660

gagtgcgtgc tgaacaaggc caccaacgtg gcccactgga ccacccctag cctgaagtgc      720

atcagagatc ccgccctggt gcatcagcgg cctgcccctc caagcacagt gacaacagct      780

ggcgtgaccc cccagcctga gagcctgagc ccttctggaa aagagcctgc cgccagcagc      840

cccagcagca acaatactgc cgccaccaca gccgccatcg tgcctggatc tcagctgatg      900

cccagcaaga gccctagcac cggcaccacc gagatcagca gccacgagtc tagccacggc      960

accccatctc agaccaccgc caagaactgg gagctgacag ccagcgcctc tcaccagcct     1020

ccaggcgtgt accctcaggg ccacagcgat accacagtgg ccatcagcac ctccaccgtg     1080

ctgctgtgtg gactgagcgc cgtgtcactg ctggcctgct acctgaagtc cagacag        1137


<210>  26
<211>  66
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  P2A

<400>  26
ggatccggag ctactaactt cagcctgctg aagcaggctg gagacgtgga ggagaaccct       60

ggacct                                                                  66


<210>  27
<211>  765
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  hnCD16

<400>  27
atgtggcagc tgctgctgcc tacagctctc ctgctgctgg tgtccgccgg catgagaacc       60

gaggatctgc ctaaggccgt ggtgttcctg gaaccccagt ggtacagagt gctggaaaag      120

gacagcgtga ccctgaagtg ccagggcgcc tacagccctg aggacaattc cacacagtgg      180

tttcacaatg agagcctcat ctcaagccag gcctcgagct acttcatcga cgccgccacc      240

gtggacgaca gcggcgagta tagatgccag accaacctga gcaccctgag cgaccccgtg      300

cagctggaag tgcacatcgg atggctgctg ctgcaggccc ccagatgggt gttcaaagaa      360

gaggacccca tccacctgag atgccactct tggaagaaca ccgccctgca caaagtgacc      420

tacctgcaga acggcaaggg cagaaagtac ttccaccaca acagcgactt ctacatcccc      480

aaggccaccc tgaaggactc cggctcctac ttctgcagag gcctcgtggg cagcaagaac      540

gtgtccagcg agacagtgaa catcaccatc acccagggcc tggccgtgcc taccatcagc      600

agctttttcc cacccggcta ccaggtgtcc ttctgcctcg tgatggtgct gctgttcgcc      660

gtggacaccg gcctgtactt cagcgtgaaa acaaacatca gaagcagcac ccgggactgg      720

aaggaccaca agttcaagtg gcggaaggac ccccaggaca agtga                      765


<210>  28
<211>  272
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TKpA

<400>  28
gggggaggct aactgaaaca cggaaggaga caataccgga aggaacccgc gctatgacgg       60

caataaaaag acagaataaa acgcacgggt gttgggtcgt ttgttcataa acgcggggtt      120

cggtcccagg gctggcactc tgtcgatacc ccaccgagac cccattgggg ccaatacgcc      180

cgcgtttctt ccttttcccc accccacccc ccaagttcgg gtgaaggccc agggctcgca      240

gccaacgtcg gggcggcagg ccctgccata gc                                    272


<210>  29
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  RHA/CD38

<400>  29
gatgcgtcaa gtacactgaa attcatcctg agatgaggtg ggttggcgac taaggcgcac       60

cggtgggcac tgcggggaca gcagggcccc gcgcgcaggg aagccgcccg gatcgcccgg      120

aaccgggcat cttccgtggc gggtcagccg agagcccgcc gggtggtgct gagtagggag      180

tcccgggctc ggggctccgc gggccgcttt caggagcagc tggccttggc accgagcgtg      240

cccgcgggag gcgggggggg gcgctgctcg gtggctctgc tgcgtagccg gtgaacactt      300

ggcaccgatg cccgccttct gggcaaggtg ccctgagccc agcccctcgc cgggctgcag      360

cccaccctcg gcgcgctcag cccgcttcac cgcttcaggg acggaataga actcgcagat      420

gcagggtgtc gctgacattt tcaacttttt ctgcggtttc cgcccgctgt ctctgacccg      480

aaagtgcccc cggacggtta cagaggacac ttaagtggtt tgcaaagcct gtggtagggg      540

aggagggtgt agaagggcca aaccacggaa cttagtttta ttcatttata taaagcagca      600


<210>  30
<211>  600
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  LHA/CD38

<400>  30
agagggcatt gtgtgcacac acgtatagaa gcaggcagcc caccctcatg ctttccagga       60

agcaaatgtg gctcaggtgt aaagtgcccg gttgatgaag ggagttagcg gagggagtat      120

aaggatgtac tgtctgcccc cttaggacac ctgcagagga ttaaggtggc tgtttctccc      180

tggaggtgga gtgggtgggt cactgcacag gagcctatag ttgttggtct tttaaactct      240

tattggtgta accagccacg gaactctgag gcaaggggtt gggggtggga agggaaacag      300

agaaaaggca agtgaaacag aaggggaggt gcagtttcag aacccagcca gcctctctct      360

tgctgcctag cctcctgccg gcctcatctt cgcccagcca accccgcctg gagccctatg      420

gccaactgcg agttcagccc ggtgtccggg gacaaaccct gctgccggct ctctaggaga      480

gcccaactct gtcttggcgt cagtatcctg gtcctgatcc tcgtcgtggt gctcgcggtg      540

gtcgtcccga ggtggcgcca gcagtggagc ggtccgggca ccaccaagcg ctttcccgag      600


<210>  31
<211>  63
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  T2A

<400>  31
ggcagcggag agggcagagg aagtcttcta acatgcggtg acgtggagga gaatcccggc       60

cct                                                                     63


<210>  32
<211>  601
<212>  DNA
<213>  Artificial sequence

<220>
<223>  RHA/CD38

<400>  32
cgatgcgtca agtacactga aattcatcct gagatgaggt gggttggcga ctaaggcgca       60

ccggtgggca ctgcggggac agcagggccc cgcgcgcagg gaagccgccc ggatcgcccg      120

gaaccgggca tcttccgtgg cgggtcagcc gagagcccgc cgggtggtgc tgagtaggga      180

gtcccgggct cggggctccg cgggccgctt tcaggagcag ctggccttgg caccgagcgt      240

gcccgcggga ggcggggggg ggcgctgctc ggtggctctg ctgcgtagcc ggtgaacact      300

tggcaccgat gcccgccttc tgggcaaggt gccctgagcc cagcccctcg ccgggctgca      360

gcccaccctc ggcgcgctca gcccgcttca ccgcttcagg gacggaatag aactcgcaga      420

tgcagggtgt cgctgacatt ttcaactttt tctgcggttt ccgcccgctg tctctgaccc      480

gaaagtgccc ccggacggtt acagaggaca cttaagtggt ttgcaaagcc tgtggtaggg      540

gaggagggtg tagaagggcc aaaccacgga acttagtttt attcatttat ataaagcagc      600

a                                                                      601


<210>  33
<211>  120
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV heavy chain-1 (VH)

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  34
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV light chain-1 (VL)

<400>  34

Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  35
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV heavy chain-2 (VH)

<400>  35

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV light chain-2 (VL)

<400>  36

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  37
<211>  119
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV heavy chain-3 (VH)

<400>  37

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Ser Phe Pro Asp Tyr 
            20                  25                  30          


Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BCMA scFV light chain-3 (VL)

<400>  38

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  39
<211>  266
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu 
            20                  25                  30          


Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe 
        35                  40                  45              


Thr Phe Ser Arg Tyr Trp Phe Ser Trp Val Arg Gln Ala Pro Gly Lys 
    50                  55                  60                  


Gly Leu Val Trp Val Gly Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn 
65                  70                  75                  80  


Tyr Ala Pro Ser Leu Lys Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala 
                85                  90                  95      


Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Tyr Cys Ala Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr 
        115                 120                 125             


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Ser Thr 
    130                 135                 140                 


Ser Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Glu 
145                 150                 155                 160 


Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly Glu 
                165                 170                 175     


Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Ser Val Glu Ser Asn Val 
            180                 185                 190         


Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala Leu Ile Tyr 
        195                 200                 205             


Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro Ala Arg Phe Ser Gly Ser 
    210                 215                 220                 


Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser Glu 
225                 230                 235                 240 


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Tyr Pro Leu Thr 
                245                 250                 255     


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            260                 265     


<210>  40
<211>  263
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu 
            20                  25                  30          


Ser Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln 
        35                  40                  45              


Ser Val Glu Ser Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
    50                  55                  60                  


Pro Arg Ala Leu Ile Tyr Ser Ala Ser Leu Arg Phe Ser Gly Ile Pro 
65                  70                  75                  80  


Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Asn Asn Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
    130                 135                 140                 


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
145                 150                 155                 160 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr Trp 
                165                 170                 175     


Phe Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Val Trp Val Gly 
            180                 185                 190         


Glu Ile Asn Pro Ser Ser Ser Thr Ile Asn Tyr Ala Pro Ser Leu Lys 
        195                 200                 205             


Asp Lys Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu 
    210                 215                 220                 


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
225                 230                 235                 240 


Ser Leu Tyr Tyr Asp Tyr Gly Asp Ala Tyr Asp Tyr Trp Gly Gln Gly 
                245                 250                 255     


Thr Leu Val Thr Val Ser Ser 
            260             


<210>  41
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Pro Asp Tyr Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                85                  90                  95      


Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Gln Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly 
            180                 185                 190         


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
        195                 200                 205             


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
225                 230                 235                 240 


Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Ser Gln Ser Ser Ile 
                245                 250                 255     


Tyr Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270 


<210>  42
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Ser Val Thr Pro Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr 
            100                 105                 110         


Tyr Cys Ser Gln Ser Ser Ile Tyr Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr Phe Ala Ser Gly Asn 
        195                 200                 205             


Ser Glu Tyr Asn Gln Lys Phe Thr Gly Arg Val Thr Met Thr Arg Asp 
    210                 215                 220                 


Thr Ser Ile Asn Thr Ala Tyr Met Glu Leu Ser Ser Leu Thr Ser Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Phe Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr 
                245                 250                 255     


Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            260                 265                 270 


<210>  43
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val 
            20                  25                  30          


Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Ser Phe Pro Asp Tyr Tyr Ile Asn Trp Val Arg Gln Ala Pro Gly Gln 
    50                  55                  60                  


Gly Leu Glu Trp Met Gly Trp Ile Tyr Phe Ala Ser Gly Asn Ser Glu 
65                  70                  75                  80  


Tyr Asn Gln Lys Phe Thr Gly Arg Val Thr Met Thr Arg Asp Thr Ser 
                85                  90                  95      


Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr 
            100                 105                 110         


Ala Val Tyr Phe Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr Phe Asp 
        115                 120                 125             


Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Ser Thr Ser 
    130                 135                 140                 


Gly Ser Gly Lys Pro Gly Ser Gly Glu Gly Ser Thr Lys Gly Asp Ile 
145                 150                 155                 160 


Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Pro Gly Glu Pro 
                165                 170                 175     


Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Val His Ser Asn Gly 
            180                 185                 190         


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
        195                 200                 205             


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
    210                 215                 220                 


Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu Lys Ile Ser Arg 
225                 230                 235                 240 


Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Glu Thr Ser His 
                245                 250                 255     


Val Pro Trp Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            260                 265                 270 


<210>  44
<211>  270
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu 
            20                  25                  30          


Ser Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Val His Ser Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg 
65                  70                  75                  80  


Phe Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr 
            100                 105                 110         


Tyr Cys Ala Glu Thr Ser His Val Pro Trp Thr Phe Gly Gln Gly Thr 
        115                 120                 125             


Lys Leu Glu Ile Lys Gly Ser Thr Ser Gly Ser Gly Lys Pro Gly Ser 
    130                 135                 140                 


Gly Glu Gly Ser Thr Lys Gly Gln Val Gln Leu Val Gln Ser Gly Ala 
145                 150                 155                 160 


Glu Val Lys Lys Pro Gly Ala Ser Val Lys Val Ser Cys Lys Ala Ser 
                165                 170                 175     


Gly Tyr Ser Phe Pro Asp Tyr Tyr Ile Asn Trp Val Arg Gln Ala Pro 
            180                 185                 190         


Gly Gln Gly Leu Glu Trp Met Gly Trp Ile Tyr Phe Ala Ser Gly Asn 
        195                 200                 205             


Ser Glu Tyr Asn Gln Lys Phe Thr Gly Arg Val Thr Met Thr Arg Asp 
    210                 215                 220                 


Thr Ser Ser Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser Glu 
225                 230                 235                 240 


Asp Thr Ala Val Tyr Phe Cys Ala Ser Leu Tyr Asp Tyr Asp Trp Tyr 
                245                 250                 255     


Phe Asp Val Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
            260                 265                 270 

<210>  45
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu 
1               5                   10                  15      


Thr Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Met Phe Thr Asn Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Lys Gln Ala Pro Glu Lys Gly Leu Lys Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr His Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe 
    50                  55                  60                  


Lys Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys 
                85                  90                  95      


Val Arg Thr Tyr Gly Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  46
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Thr Ser Ile Leu His Leu Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Phe Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
            100                 105         


<210>  47
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gln Ile Gln Leu Val Gln Ser Gly Pro Glu Leu 
            20                  25                  30          


Lys Lys Pro Gly Glu Thr Val Lys Val Ser Cys Lys Ala Ser Gly Tyr 
        35                  40                  45              


Met Phe Thr Asn Tyr Ala Met Asn Trp Val Lys Gln Ala Pro Glu Lys 
    50                  55                  60                  


Gly Leu Lys Trp Met Gly Trp Ile Asn Thr His Thr Gly Asp Pro Thr 
65                  70                  75                  80  


Tyr Ala Asp Asp Phe Lys Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser 
                85                  90                  95      


Ala Ser Thr Ala Tyr Leu Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr 
            100                 105                 110         


Ala Thr Tyr Phe Cys Val Arg Thr Tyr Gly Asn Tyr Ala Met Asp Tyr 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln 
145                 150                 155                 160 


Thr Thr Ser Ser Leu Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser 
                165                 170                 175     


Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln 
            180                 185                 190         


Lys Pro Asp Gly Thr Val Lys Leu Leu Ile Tyr Asp Thr Ser Ile Leu 
        195                 200                 205             


His Leu Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
    210                 215                 220                 


Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr 
225                 230                 235                 240 


Tyr Cys Gln Gln Tyr Ser Lys Phe Pro Arg Thr Phe Gly Gly Gly Thr 
                245                 250                 255     


Thr Leu Glu Ile Lys 
            260     


<210>  48
<211>  261
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln 
        35                  40                  45              


Asp Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr 
    50                  55                  60                  


Val Lys Leu Leu Ile Tyr Asp Thr Ser Ile Leu His Leu Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile 
                85                  90                  95      


Ser Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Tyr 
            100                 105                 110         


Ser Lys Phe Pro Arg Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys 
        115                 120                 125             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
    130                 135                 140                 


Ile Gln Leu Val Gln Ser Gly Pro Glu Leu Lys Lys Pro Gly Glu Thr 
145                 150                 155                 160 


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Met Phe Thr Asn Tyr Ala 
                165                 170                 175     


Met Asn Trp Val Lys Gln Ala Pro Glu Lys Gly Leu Lys Trp Met Gly 
            180                 185                 190         


Trp Ile Asn Thr His Thr Gly Asp Pro Thr Tyr Ala Asp Asp Phe Lys 
        195                 200                 205             


Gly Arg Ile Ala Phe Ser Leu Glu Thr Ser Ala Ser Thr Ala Tyr Leu 
    210                 215                 220                 


Gln Ile Asn Asn Leu Lys Asn Glu Asp Thr Ala Thr Tyr Phe Cys Val 
225                 230                 235                 240 


Arg Thr Tyr Gly Asn Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Ser 
                245                 250                 255     


Val Thr Val Ser Ser 
            260     
