                               SEQUENCE LISTING

<110> UNIVERSITY OF MASSACHUSETTS
 
<120> TARGETING RLIM TO MODULATE WEIGHT AND OBESITY

<130> 07917-0414WO1

<140> PCT/US2020/052856
<141> 2020-09-25

<150> 62/905,694
<151> 2019-09-25

<160> 51    

<170> PatentIn version 3.5

<210> 1
<211> 624
<212> PRT
<213> Homo sapiens

<400> 1
Met Glu Asn Ser Asp Ser Asn Asp Lys Gly Ser Gly Asp Gln Ser Ala 
1               5                   10                  15      


Ala Gln Arg Arg Ser Gln Met Asp Arg Leu Asp Arg Glu Glu Ala Phe 
            20                  25                  30          


Tyr Gln Phe Val Asn Asn Leu Ser Glu Glu Asp Tyr Arg Leu Met Arg 
        35                  40                  45              


Asp Asn Asn Leu Leu Gly Thr Pro Gly Glu Ser Thr Glu Glu Glu Leu 
    50                  55                  60                  


Leu Arg Arg Leu Gln Gln Ile Lys Glu Gly Pro Pro Pro Gln Asn Ser 
65                  70                  75                  80  


Asp Glu Asn Arg Gly Gly Asp Ser Ser Asp Asp Val Ser Asn Gly Asp 
                85                  90                  95      


Ser Ile Ile Asp Trp Leu Asn Ser Val Arg Gln Thr Gly Asn Thr Thr 
            100                 105                 110         


Arg Ser Gly Gln Arg Gly Asn Gln Ser Trp Arg Ala Val Ser Arg Thr 
        115                 120                 125             


Asn Pro Asn Ser Gly Asp Phe Arg Phe Ser Leu Glu Ile Asn Val Asn 
    130                 135                 140                 


Arg Asn Asn Gly Ser Gln Asn Ser Glu Asn Glu Asn Glu Pro Ser Ala 
145                 150                 155                 160 


Arg Arg Ser Ser Gly Glu Asn Val Glu Asn Asn Ser Gln Arg Gln Val 
                165                 170                 175     


Glu Asn Pro Arg Ser Glu Ser Thr Ser Ala Arg Pro Ser Arg Ser Glu 
            180                 185                 190         


Arg Asn Ser Thr Glu Ala Leu Thr Glu Val Pro Pro Thr Arg Gly Gln 
        195                 200                 205             


Arg Arg Ala Arg Ser Arg Ser Pro Asp His Arg Arg Thr Arg Ala Arg 
    210                 215                 220                 


Ala Glu Arg Ser Arg Ser Pro Leu His Pro Met Ser Glu Ile Pro Arg 
225                 230                 235                 240 


Arg Ser His His Ser Ile Ser Ser Gln Thr Phe Glu His Pro Leu Val 
                245                 250                 255     


Asn Glu Thr Glu Gly Ser Ser Arg Thr Arg His His Val Thr Leu Arg 
            260                 265                 270         


Gln Gln Ile Ser Gly Pro Glu Leu Leu Ser Arg Gly Leu Phe Ala Ala 
        275                 280                 285             


Ser Gly Thr Arg Asn Ala Ser Gln Gly Ala Gly Ser Ser Asp Thr Ala 
    290                 295                 300                 


Ala Ser Gly Glu Ser Thr Gly Ser Gly Gln Arg Pro Pro Thr Ile Val 
305                 310                 315                 320 


Leu Asp Leu Gln Val Arg Arg Val Arg Pro Gly Glu Tyr Arg Gln Arg 
                325                 330                 335     


Asp Ser Ile Ala Ser Arg Thr Arg Ser Arg Ser Gln Thr Pro Asn Asn 
            340                 345                 350         


Thr Val Thr Tyr Glu Ser Glu Arg Gly Gly Phe Arg Arg Thr Phe Ser 
        355                 360                 365             


Arg Ser Glu Arg Ala Gly Val Arg Thr Tyr Val Ser Thr Ile Arg Ile 
    370                 375                 380                 


Pro Ile Arg Arg Ile Leu Asn Thr Gly Leu Ser Glu Thr Thr Ser Val 
385                 390                 395                 400 


Ala Ile Gln Thr Met Leu Arg Gln Ile Met Thr Gly Phe Gly Glu Leu 
                405                 410                 415     


Ser Tyr Phe Met Tyr Ser Asp Ser Asp Ser Glu Pro Thr Gly Ser Val 
            420                 425                 430         


Ser Asn Arg Asn Met Glu Arg Ala Glu Ser Arg Ser Gly Arg Gly Gly 
        435                 440                 445             


Ser Gly Gly Gly Ser Ser Ser Gly Ser Ser Ser Ser Ser Ser Ser Ser 
    450                 455                 460                 


Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Pro Ser Ser Ser 
465                 470                 475                 480 


Ser Gly Gly Glu Ser Ser Glu Thr Ser Ser Asp Leu Phe Glu Gly Ser 
                485                 490                 495     


Asn Glu Gly Ser Ser Ser Ser Gly Ser Ser Gly Ala Arg Arg Glu Gly 
            500                 505                 510         


Arg His Arg Ala Pro Val Thr Phe Asp Glu Ser Gly Ser Leu Pro Phe 
        515                 520                 525             


Leu Ser Leu Ala Gln Phe Phe Leu Leu Asn Glu Asp Asp Asp Asp Gln 
    530                 535                 540                 


Pro Arg Gly Leu Thr Lys Glu Gln Ile Asp Asn Leu Ala Met Arg Ser 
545                 550                 555                 560 


Phe Gly Glu Asn Asp Ala Leu Lys Thr Cys Ser Val Cys Ile Thr Glu 
                565                 570                 575     


Tyr Thr Glu Gly Asn Lys Leu Arg Lys Leu Pro Cys Ser His Glu Tyr 
            580                 585                 590         


His Val His Cys Ile Asp Arg Trp Leu Ser Glu Asn Ser Thr Cys Pro 
        595                 600                 605             


Ile Cys Arg Arg Ala Val Leu Ala Ser Gly Asn Arg Glu Ser Val Val 
    610                 615                 620                 


<210> 2
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_1959_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 2
aggcaacaaa cuuca                                                        15


<210> 3
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2724_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 3
uauuuaucuu gugga                                                        15


<210> 4
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2747_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 4
aaagccuaug cuuga                                                        15


<210> 5
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2772_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 5
aaaaucacau ucaua                                                        15


<210> 6
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2815_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 6
aggcucagua cuuua                                                        15


<210> 7
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2831_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 7
caaugcacug uugua                                                        15


<210> 8
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_3562_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 8
cauguugggu uauua                                                        15


<210> 9
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4070_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 9
aaggaaauaa uguca                                                        15


<210> 10
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4084_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 10
caaacaaagc uucaa                                                        15


<210> 11
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4137_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 11
cgcuuaugua auaca                                                        15


<210> 12
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4140_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 12
uuauguaaua cauua                                                        15


<210> 13
<211> 15
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_6849_s siRNA


<220>
<221> modified_base
<222> (1)..(4)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (5)..(7)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (10)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(15)
<223> Phosphorothioate linkage

<220>
<223> 3' TegChol

<400> 13
uagguacgca guuga                                                        15


<210> 14
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_1959_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 14
ugaaguuugu ugccuucugu                                                   20


<210> 15
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2724_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 15
uccacaagau aaauaucuca                                                   20


<210> 16
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2747_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 16
ucaagcauag gcuuuuuaau                                                   20


<210> 17
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2772_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 17
uaugaaugug auuuuuuuca                                                   20


<210> 18
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2815_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 18
uaaaguacug agccucuaca                                                   20


<210> 19
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2831_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 19
uacaacagug cauuggaaaa                                                   20


<210> 20
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_3562_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 20
uaauaaccca acaugacuuc                                                   20


<210> 21
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4070_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 21
ugacauuauu uccuugcaag                                                   20


<210> 22
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4084_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 22
uugaagcuuu guuuggacau                                                   20


<210> 23
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4137_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 23
uguauuacau aagcgccaua                                                   20


<210> 24
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4140_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 24
uaauguauua cauaagcgcc                                                   20


<210> 25
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_6849_as siRNA


<220>
<223> 5' Phosphate

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (13)..(20)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<400> 25
ucaacugcgu accuacucca                                                   20


<210> 26
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_1959 siRNA

<400> 26
acagaaggca acaaacuucg                                                   20


<210> 27
<211> 45
<212> DNA
<213> Homo sapiens

<400> 27
tgcattacag aatacacaga aggcaacaaa cttcgtaaac tacct                       45


<210> 28
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2724 siRNA

<400> 28
ugagauauuu aucuugugga                                                   20


<210> 29
<211> 45
<212> DNA
<213> Homo sapiens

<400> 29
aatttagagt ttaattgaga tatttatctt gtggaaatat taaaa                       45


<210> 30
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2747 siRNA

<400> 30
auuaaaaagc cuaugcuugu                                                   20


<210> 31
<211> 45
<212> DNA
<213> Homo sapiens

<400> 31
ttatcttgtg gaaatattaa aaagcctatg cttgtgtaag tgaaa                       45


<210> 32
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2772 siRNA

<400> 32
ugaaaaaaau cacauucauu                                                   20


<210> 33
<211> 45
<212> DNA
<213> Homo sapiens

<400> 33
ctatgcttgt gtaagtgaaa aaaatcacat tcatttgttt aaaaa                       45


<210> 34
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2815 siRNA

<400> 34
uguagaggcu caguacuuuu                                                   20


<210> 35
<211> 45
<212> DNA
<213> Homo sapiens

<400> 35
aatgtaaagc tattttgtag aggctcagta cttttccaat gcact                       45


<210> 36
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_2831 siRNA

<400> 36
uuuuccaaug cacuguugua                                                   20


<210> 37
<211> 45
<212> DNA
<213> Homo sapiens

<400> 37
gtagaggctc agtacttttc caatgcactg ttgtattaat gcatt                       45


<210> 38
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_3562 siRNA

<400> 38
gaagucaugu uggguuauuu                                                   20


<210> 39
<211> 45
<212> DNA
<213> Homo sapiens

<400> 39
attttttatt gaaaggaagt catgttgggt tatttgagat tcaaa                       45


<210> 40
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4070 siRNA

<400> 40
cuugcaagga aauaaugucc                                                   20


<210> 41
<211> 45
<212> DNA
<213> Homo sapiens

<400> 41
aggatatgta ctgctcttgc aaggaaataa tgtccaaaca aagct                       45


<210> 42
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4084 siRNA

<400> 42
auguccaaac aaagcuucac                                                   20


<210> 43
<211> 45
<212> DNA
<213> Homo sapiens

<400> 43
tcttgcaagg aaataatgtc caaacaaagc ttcacttatt ttttt                       45


<210> 44
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4137 siRNA

<400> 44
uauggcgcuu auguaauaca                                                   20


<210> 45
<211> 45
<212> DNA
<213> Homo sapiens

<400> 45
gcatatttca ctgtttatgg cgcttatgta atacattttt atctt                       45


<210> 46
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_4140 siRNA

<400> 46
ggcgcuuaug uaauacauuu                                                   20


<210> 47
<211> 45
<212> DNA
<213> Homo sapiens

<400> 47
tatttcactg tttatggcgc ttatgtaata catttttatc ttttt                       45


<210> 48
<211> 20
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      Rlim_XM_ 006527919_6849 siRNA

<400> 48
uggaguaggu acgcaguugg                                                   20


<210> 49
<211> 45
<212> DNA
<213> Homo sapiens

<400> 49
ctgtgaagtg tccagtggag taggtacgca gttggcctgg ttata                       45


<210> 50
<211> 21
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RLIM_4070_ p3_AS siRNA


<220>
<223> 5'-(E)-Vinylphosphonate 

<220>
<221> modified_base
<222> (1)..(1)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (2)..(2)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (3)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (4)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(11)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (12)..(12)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (13)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> misc_feature
<222> (14)..(21)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (15)..(15)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (16)..(16)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (17)..(19)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (20)..(20)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (21)..(21)
<223> 2'-O-Methyl nucleotide

<400> 50
ugacauuauu uccuugcaag u                                                 21


<210> 51
<211> 16
<212> RNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      RLIM_4070_ p3_S_Dio siRNA


<220>
<221> modified_base
<222> (1)..(3)
<223> 2'-O-Methyl nucleotide

<220>
<221> misc_feature
<222> (1)..(3)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (4)..(4)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (5)..(5)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (6)..(6)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (7)..(7)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (8)..(8)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (9)..(9)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (10)..(10)
<223> 2'-Fluoro nucleotide

<220>
<221> modified_base
<222> (11)..(13)
<223> 2'-O-Methyl nucleotide

<220>
<221> modified_base
<222> (14)..(14)
<223> 2'-Fluoro nucleotide

<220>
<221> misc_feature
<222> (14)..(16)
<223> Phosphorothioate linkage

<220>
<221> modified_base
<222> (15)..(16)
<223> 2'-O-Methyl nucleotide

<400> 51
caaggaaaua auguca                                                       16


