                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Carrasco, Ruben  D.
       Jiang, Meng
       Sewastianik, Tomasz
 
<120>  COMPOSITIONS AND METHODS FOR TREATMENT OF A POOR PROGNOSIS 
       SUBTYPE OF COLORECTAL CANCER

<130>  52095-587001WO

<140>  Not Yet Assigned
<141>  2020-09-24

<150>  62/907,369
<151>  2019-09-27

<160>  50    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Xaa Thr Leu 
1               5                   10                  15      


Arg Xaa Ile Gln Arg Asx Leu Phe 
            20                  


<210>  2
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Xaa Thr Leu 
1               5                   10                  15      


Arg Xaa Ile Gln Arg Met Leu Phe 
            20                  


<210>  3
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu 
1               5                   10                  15      


Arg Xaa Ile Gln Arg Xaa Leu Phe 
            20                  


<210>  4
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  4

Leu Ser Gln Glu Gln Leu Glu His Arg Glu Xaa Ser Leu Gln Xaa Leu 
1               5                   10                  15      


Arg Asp Ile Gln Arg Asx Leu Phe 
            20                  


<210>  5
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  5
aauaacacug uguauugcag c                                                 21


<210>  6
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  6
uuccagggau auucacagag g                                                 21


<210>  7
<211>  1426
<212>  PRT
<213>  Homo sapiens

<400>  7

Met His Ser Ser Asn Pro Lys Val Arg Ser Ser Pro Ser Gly Asn Thr 
1               5                   10                  15      


Gln Ser Ser Pro Lys Ser Lys Gln Glu Val Met Val Arg Pro Pro Thr 
            20                  25                  30          


Val Met Ser Pro Ser Gly Asn Pro Gln Leu Asp Ser Lys Phe Ser Asn 
        35                  40                  45              


Gln Gly Lys Gln Gly Gly Ser Ala Ser Gln Ser Gln Pro Ser Pro Cys 
    50                  55                  60                  


Asp Ser Lys Ser Gly Gly His Thr Pro Lys Ala Leu Pro Gly Pro Gly 
65                  70                  75                  80  


Gly Ser Met Gly Leu Lys Asn Gly Ala Gly Asn Gly Ala Lys Gly Lys 
                85                  90                  95      


Gly Lys Arg Glu Arg Ser Ile Ser Ala Asp Ser Phe Asp Gln Arg Asp 
            100                 105                 110         


Pro Gly Thr Pro Asn Asp Asp Ser Asp Ile Lys Glu Cys Asn Ser Ala 
        115                 120                 125             


Asp His Ile Lys Ser Gln Asp Ser Gln His Thr Pro His Ser Met Thr 
    130                 135                 140                 


Pro Ser Asn Ala Thr Ala Pro Arg Ser Ser Thr Pro Ser His Gly Gln 
145                 150                 155                 160 


Thr Thr Ala Thr Glu Pro Thr Pro Ala Gln Lys Thr Pro Ala Lys Val 
                165                 170                 175     


Val Tyr Val Phe Ser Thr Glu Met Ala Asn Lys Ala Ala Glu Ala Val 
            180                 185                 190         


Leu Lys Gly Gln Val Glu Thr Ile Val Ser Phe His Ile Gln Asn Ile 
        195                 200                 205             


Ser Asn Asn Lys Thr Glu Arg Ser Thr Ala Pro Leu Asn Thr Gln Ile 
    210                 215                 220                 


Ser Ala Leu Arg Asn Asp Pro Lys Pro Leu Pro Gln Gln Pro Pro Ala 
225                 230                 235                 240 


Pro Ala Asn Gln Asp Gln Asn Ser Ser Gln Asn Thr Arg Leu Gln Pro 
                245                 250                 255     


Thr Pro Pro Ile Pro Ala Pro Ala Pro Lys Pro Ala Ala Pro Pro Arg 
            260                 265                 270         


Pro Leu Asp Arg Glu Ser Pro Gly Val Glu Asn Lys Leu Ile Pro Ser 
        275                 280                 285             


Val Gly Ser Pro Ala Ser Ser Thr Pro Leu Pro Pro Asp Gly Thr Gly 
    290                 295                 300                 


Pro Asn Ser Thr Pro Asn Asn Arg Ala Val Thr Pro Val Ser Gln Gly 
305                 310                 315                 320 


Ser Asn Ser Ser Ser Ala Asp Pro Lys Ala Pro Pro Pro Pro Pro Val 
                325                 330                 335     


Ser Ser Gly Glu Pro Pro Thr Leu Gly Glu Asn Pro Asp Gly Leu Ser 
            340                 345                 350         


Gln Glu Gln Leu Glu His Arg Glu Arg Ser Leu Gln Thr Leu Arg Asp 
        355                 360                 365             


Ile Gln Arg Met Leu Phe Pro Asp Glu Lys Glu Phe Thr Gly Ala Gln 
    370                 375                 380                 


Ser Gly Gly Pro Gln Gln Asn Pro Gly Val Leu Asp Gly Pro Gln Lys 
385                 390                 395                 400 


Lys Pro Glu Gly Pro Ile Gln Ala Met Met Ala Gln Ser Gln Ser Leu 
                405                 410                 415     


Gly Lys Gly Pro Gly Pro Arg Thr Asp Val Gly Ala Pro Phe Gly Pro 
            420                 425                 430         


Gln Gly His Arg Asp Val Pro Phe Ser Pro Asp Glu Met Val Pro Pro 
        435                 440                 445             


Ser Met Asn Ser Gln Ser Gly Thr Ile Gly Pro Asp His Leu Asp His 
    450                 455                 460                 


Met Thr Pro Glu Gln Ile Ala Trp Leu Lys Leu Gln Gln Glu Phe Tyr 
465                 470                 475                 480 


Glu Glu Lys Arg Arg Lys Gln Glu Gln Val Val Val Gln Gln Cys Ser 
                485                 490                 495     


Leu Gln Asp Met Met Val His Gln His Gly Pro Arg Gly Val Val Arg 
            500                 505                 510         


Gly Pro Pro Pro Pro Tyr Gln Met Thr Pro Ser Glu Gly Trp Ala Pro 
        515                 520                 525             


Gly Gly Thr Glu Pro Phe Ser Asp Gly Ile Asn Met Pro His Ser Leu 
    530                 535                 540                 


Pro Pro Arg Gly Met Ala Pro His Pro Asn Met Pro Gly Ser Gln Met 
545                 550                 555                 560 


Arg Leu Pro Gly Phe Ala Gly Met Ile Asn Ser Glu Met Glu Gly Pro 
                565                 570                 575     


Asn Val Pro Asn Pro Ala Ser Arg Pro Gly Leu Ser Gly Val Ser Trp 
            580                 585                 590         


Pro Asp Asp Val Pro Lys Ile Pro Asp Gly Arg Asn Phe Pro Pro Gly 
        595                 600                 605             


Gln Gly Ile Phe Ser Gly Pro Gly Arg Gly Glu Arg Phe Pro Asn Pro 
    610                 615                 620                 


Gln Gly Leu Ser Glu Glu Met Phe Gln Gln Gln Leu Ala Glu Lys Gln 
625                 630                 635                 640 


Leu Gly Leu Pro Pro Gly Met Ala Met Glu Gly Ile Arg Pro Ser Met 
                645                 650                 655     


Glu Met Asn Arg Met Ile Pro Gly Ser Gln Arg His Met Glu Pro Gly 
            660                 665                 670         


Asn Asn Pro Ile Phe Pro Arg Ile Pro Val Glu Gly Pro Leu Ser Pro 
        675                 680                 685             


Ser Arg Gly Asp Phe Pro Lys Gly Ile Pro Pro Gln Met Gly Pro Gly 
    690                 695                 700                 


Arg Glu Leu Glu Phe Gly Met Val Pro Ser Gly Met Lys Gly Asp Val 
705                 710                 715                 720 


Asn Leu Asn Val Asn Met Gly Ser Asn Ser Gln Met Ile Pro Gln Lys 
                725                 730                 735     


Met Arg Glu Ala Gly Ala Gly Pro Glu Glu Met Leu Lys Leu Arg Pro 
            740                 745                 750         


Gly Gly Ser Asp Met Leu Pro Ala Gln Gln Lys Met Val Pro Leu Pro 
        755                 760                 765             


Phe Gly Glu His Pro Gln Gln Glu Tyr Gly Met Gly Pro Arg Pro Phe 
    770                 775                 780                 


Leu Pro Met Ser Gln Gly Pro Gly Ser Asn Ser Gly Leu Arg Asn Leu 
785                 790                 795                 800 


Arg Glu Pro Ile Gly Pro Asp Gln Arg Thr Asn Ser Arg Leu Ser His 
                805                 810                 815     


Met Pro Pro Leu Pro Leu Asn Pro Ser Ser Asn Pro Thr Ser Leu Asn 
            820                 825                 830         


Thr Ala Pro Pro Val Gln Arg Gly Leu Gly Arg Lys Pro Leu Asp Ile 
        835                 840                 845             


Ser Val Ala Gly Ser Gln Val His Ser Pro Gly Ile Asn Pro Leu Lys 
    850                 855                 860                 


Ser Pro Thr Met His Gln Val Gln Ser Pro Met Leu Gly Ser Pro Ser 
865                 870                 875                 880 


Gly Asn Leu Lys Ser Pro Gln Thr Pro Ser Gln Leu Ala Gly Met Leu 
                885                 890                 895     


Ala Gly Pro Ala Ala Ala Ala Ser Ile Lys Ser Pro Pro Val Leu Gly 
            900                 905                 910         


Ser Ala Ala Ala Ser Pro Val His Leu Lys Ser Pro Ser Leu Pro Ala 
        915                 920                 925             


Pro Ser Pro Gly Trp Thr Ser Ser Pro Lys Pro Pro Leu Gln Ser Pro 
    930                 935                 940                 


Gly Ile Pro Pro Asn His Lys Ala Pro Leu Thr Met Ala Ser Pro Ala 
945                 950                 955                 960 


Met Leu Gly Asn Val Glu Ser Gly Gly Pro Pro Pro Pro Thr Ala Ser 
                965                 970                 975     


Gln Pro Ala Ser Val Asn Ile Pro Gly Ser Leu Pro Ser Ser Thr Pro 
            980                 985                 990         


Tyr Thr Met Pro Pro Glu Pro Thr  Leu Ser Gln Asn Pro  Leu Ser Ile 
        995                 1000                 1005             


Met Met  Ser Arg Met Ser Lys  Phe Ala Met Pro Ser  Ser Thr Pro 
    1010                 1015                 1020             


Leu Tyr  His Asp Ala Ile Lys  Thr Val Ala Ser Ser  Asp Asp Asp 
    1025                 1030                 1035             


Ser Pro  Pro Ala Arg Ser Pro  Asn Leu Pro Ser Met  Asn Asn Met 
    1040                 1045                 1050             


Pro Gly  Met Gly Ile Asn Thr  Gln Asn Pro Arg Ile  Ser Gly Pro 
    1055                 1060                 1065             


Asn Pro  Val Val Pro Met Pro  Thr Leu Ser Pro Met  Gly Met Thr 
    1070                 1075                 1080             


Gln Pro  Leu Ser His Ser Asn  Gln Met Pro Ser Pro  Asn Ala Val 
    1085                 1090                 1095             


Gly Pro  Asn Ile Pro Pro His  Gly Val Pro Met Gly  Pro Gly Leu 
    1100                 1105                 1110             


Met Ser  His Asn Pro Ile Met  Gly His Gly Ser Gln  Glu Pro Pro 
    1115                 1120                 1125             


Met Val  Pro Gln Gly Arg Met  Gly Phe Pro Gln Gly  Phe Pro Pro 
    1130                 1135                 1140             


Val Gln  Ser Pro Pro Gln Gln  Val Pro Phe Pro His  Asn Gly Pro 
    1145                 1150                 1155             


Ser Gly  Gly Gln Gly Ser Phe  Pro Gly Gly Met Gly  Phe Pro Gly 
    1160                 1165                 1170             


Glu Gly  Pro Leu Gly Arg Pro  Ser Asn Leu Pro Gln  Ser Ser Ala 
    1175                 1180                 1185             


Asp Ala  Ala Leu Cys Lys Pro  Gly Gly Pro Gly Gly  Pro Asp Ser 
    1190                 1195                 1200             


Phe Thr  Val Leu Gly Asn Ser  Met Pro Ser Val Phe  Thr Asp Pro 
    1205                 1210                 1215             


Asp Leu  Gln Glu Val Ile Arg  Pro Gly Ala Thr Gly  Ile Pro Glu 
    1220                 1225                 1230             


Phe Asp  Leu Ser Arg Ile Ile  Pro Ser Glu Lys Pro  Ser Gln Thr 
    1235                 1240                 1245             


Leu Gln  Tyr Phe Pro Arg Gly  Glu Val Pro Gly Arg  Lys Gln Pro 
    1250                 1255                 1260             


Gln Gly  Pro Gly Pro Gly Phe  Ser His Met Gln Gly  Met Met Gly 
    1265                 1270                 1275             


Glu Gln  Ala Pro Arg Met Gly  Leu Ala Leu Pro Gly  Met Gly Gly 
    1280                 1285                 1290             


Pro Gly  Pro Val Gly Thr Pro  Asp Ile Pro Leu Gly  Thr Ala Pro 
    1295                 1300                 1305             


Ser Met  Pro Gly His Asn Pro  Met Arg Pro Pro Ala  Phe Leu Gln 
    1310                 1315                 1320             


Gln Gly  Met Met Gly Pro His  His Arg Met Met Ser  Pro Ala Gln 
    1325                 1330                 1335             


Ser Thr  Met Pro Gly Gln Pro  Thr Leu Met Ser Asn  Pro Ala Ala 
    1340                 1345                 1350             


Ala Val  Gly Met Ile Pro Gly  Lys Asp Arg Gly Pro  Ala Gly Leu 
    1355                 1360                 1365             


Tyr Thr  His Pro Gly Pro Val  Gly Ser Pro Gly Met  Met Met Ser 
    1370                 1375                 1380             


Met Gln  Gly Met Met Gly Pro  Gln Gln Asn Ile Met  Ile Pro Pro 
    1385                 1390                 1395             


Gln Met  Arg Pro Arg Gly Met  Ala Ala Asp Val Gly  Met Gly Gly 
    1400                 1405                 1410             


Phe Ser  Gln Gly Pro Gly Asn  Pro Gly Asn Met Met  Phe 
    1415                 1420                 1425     


<210>  8
<211>  6192
<212>  DNA
<213>  Homo sapiens

<400>  8
agaccagagc agacaatagg cccctaaagt gttcccccta agttgctttg atgttgtcct       60

ggtgtcttga taccaggagg ccagggattg cgggaaaagg gtcttttttg tcttcattca      120

ctttcccccc tcagtttctg aaatgattct ccagaatttc tcctcataaa aaaggactga      180

atgtgggccc agttggcgtc attctgcttt gacctaaaca ttcccatctg attgggtggc      240

agagatcatt tttggaaagt tcttccgtgt cccgatgtag aagaaatagc aaattggaca      300

tattgaaaga caagggtcat ctttgagaag ggggttcctg gactcctcac ctccaggatg      360

agcactgcag tgtcgtgacc cttggggttt tgtatgccct ggagatgcga gattttcctc      420

tggcagcagg aggcacgcac ccagagaatg ctggagctgc aaggggaaag gacccacttc      480

cacagcagag aaaaacaaag aggaaaaagg catacaggca gcgagcgcta agggacgcac      540

ccagcaagca gtgggccagt gccactgccc ccagcagctg tttctgctgc aacccgagag      600

gaactcggtg agcctgtccc gtttgtgact gcaagctcag gatttcaatc aatgcattcc      660

agtaacccta aagtgaggag ctctccatca ggaaacacac agagtagccc taagtcaaag      720

caggaggtga tggtccgtcc ccctacagtg atgtccccat ctggaaaccc ccagctggat      780

tccaaattct ccaatcaggg taaacagggg ggctcagcca gccaatccca gccatccccc      840

tgtgactcca agagtggggg ccatacccct aaagcactcc ctggcccagg tgggagcatg      900

gggctgaaga atggggctgg aaatggtgcc aagggcaagg ggaaaaggga gcgaagtatt      960

tccgccgact cctttgatca gagagatcct gggactccaa acgatgactc tgacattaaa     1020

gaatgtaatt ctgctgacca cataaagtcc caggattccc agcacacacc acactcgatg     1080

accccatcaa atgctacagc ccccaggtct tctaccccct cccatggcca aactactgcc     1140

acagagccca cacctgctca gaagactcca gccaaagtgg tgtacgtgtt ttctactgag     1200

atggccaata aagctgcaga agctgttttg aagggccagg ttgaaactat cgtctctttc     1260

cacatccaga acatttctaa caacaagaca gagagaagca cagcgcctct gaacacacag     1320

atatctgccc ttcggaatga tccgaaacct ctcccacaac agcccccagc tccggccaac     1380

caggaccaga attcttccca gaataccaga ctgcagccaa ctccacccat tccggcacca     1440

gcacccaagc ctgccgcacc cccacgtccc ctggaccggg agagtcctgg ggtagaaaac     1500

aaactgattc cttctgtagg aagtcctgcc agctccactc cactgccccc agatggtact     1560

gggcccaact caactcccaa caatagggca gtgacccctg tctcccaggg gagcaatagc     1620

tcttcagcag atcccaaagc ccctccgcct ccaccagtgt ccagtggcga gccccccaca     1680

ctgggagaga atcccgatgg cctatctcag gagcagctgg agcaccggga gcgctcctta     1740

caaactctca gagatatcca gcgcatgctt tttcctgatg agaaagaatt cacaggagca     1800

caaagtgggg gaccgcagca gaatcctggg gtattagatg ggcctcagaa aaaaccagaa     1860

gggccaatac aggccatgat ggcccaatcc caaagcctag gtaagggacc tgggccccgg     1920

acagacgtgg gagctccatt tggccctcaa ggacatagag atgtaccctt ttctccagat     1980

gaaatggttc caccttctat gaactcccag tctgggacca taggacccga ccaccttgac     2040

catatgactc ccgagcagat agcgtggctg aaactgcagc aggagtttta tgaagagaag     2100

aggaggaagc aggaacaagt ggttgtccag cagtgttccc tccaggacat gatggtccat     2160

cagcacgggc ctcggggagt ggtccgagga cccccccctc cataccagat gacccctagt     2220

gaaggctggg cacctggggg tacagagcca ttttctgatg gtatcaacat gccacattct     2280

ctgcccccga ggggcatggc tccccacccc aacatgccag ggagccagat gcgcctccct     2340

ggatttgcag gcatgataaa ctctgaaatg gaagggccga atgtccccaa ccctgcatct     2400

agaccaggtc tttctggagt cagttggcca gatgatgtgc caaaaatccc agatggtcga     2460

aattttcctc ctggccaggg cattttcagc ggtcctggcc gaggggaacg cttcccaaac     2520

ccccaaggat tgtctgaaga gatgtttcag cagcagctgg cagagaaaca gctgggtctc     2580

cccccaggga tggccatgga aggcatcagg cccagcatgg agatgaacag gatgattcca     2640

ggctcccagc gccacatgga gcctgggaat aaccccattt tccctcgaat accagttgag     2700

ggccctctga gtccttctag gggtgacttt ccaaaaggaa ttcccccaca gatgggccct     2760

ggtcgggaac ttgagtttgg gatggttcct agtgggatga agggagatgt caatctaaat     2820

gtcaacatgg gatccaactc tcagatgata cctcagaaga tgagagaggc tggggcgggc     2880

cctgaggaga tgctgaaatt acgcccaggt ggctcagaca tgctgcctgc tcagcagaag     2940

atggtgccac tgccatttgg tgagcacccc cagcaggagt atggcatggg ccccagacca     3000

ttccttccca tgtctcaggg tccaggcagc aacagtggct tgcggaatct cagagaacca     3060

attgggcccg accagaggac taacagccgg ctcagtcata tgccaccact acctctcaac     3120

ccttccagta accccaccag cctcaacaca gctcctccag ttcagcgcgg cctggggcgg     3180

aagcccttgg atatatctgt ggcaggcagc caggtgcatt ccccaggcat taaccctctg     3240

aagtctccca cgatgcacca agtccagtca ccaatgctgg gctcgccctc ggggaacctc     3300

aagtcccccc agactccatc gcagctggca ggcatgctgg cgggcccagc tgctgctgct     3360

tccattaagt ccccccctgt tttggggtct gctgctgctt cacctgtcca cctcaagtct     3420

ccatcacttc ctgccccgtc acctggatgg acctcttctc caaaacctcc ccttcagagt     3480

cctgggatcc ctccaaacca taaagcaccc ctcaccatgg cctccccagc catgctggga     3540

aatgtagagt caggtggccc cccacctcct acagccagcc agcctgcctc tgtgaatatc     3600

cctggaagtc ttccctctag tacaccttat accatgcctc cagagccaac cctttcccag     3660

aacccactct ctattatgat gtctcgaatg tccaagtttg caatgcccag ttccaccccg     3720

ttataccatg atgctatcaa gactgtggcc agctcagatg acgactcccc tccagctcgt     3780

tctcccaact tgccatcaat gaataatatg ccaggaatgg gcattaatac acagaatcct     3840

cgaatttcag gtccaaaccc cgtggttccg atgccaaccc tcagcccaat gggaatgacc     3900

cagccacttt ctcactccaa tcagatgccc tctccaaatg ccgtgggacc caacatacct     3960

cctcatgggg tcccaatggg gcctggcttg atgtcacaca atcctatcat ggggcatggg     4020

tcccaggagc caccgatggt acctcaagga cggatgggct tcccccaggg cttccctcca     4080

gtacagtctc ccccacagca ggttccattc cctcacaatg gccccagtgg ggggcagggc     4140

agcttcccag gagggatggg tttcccagga gaaggccccc ttggccgccc cagcaacctg     4200

ccccaaagtt cagcagatgc agcactttgc aagcctggag gccccggggg tcctgactcc     4260

ttcactgtcc tggggaacag catgccttcg gtgtttacag acccagatct gcaggaggtc     4320

atccgacctg gagccaccgg aatacctgag tttgatctat cccgcattat tccatctgag     4380

aagcccagcc agacgctgca atatttccct cgaggggaag ttccaggccg taaacagccc     4440

cagggtcctg gacctgggtt ttcacacatg caggggatga tgggcgaaca agcccccaga     4500

atgggactag cattacctgg catgggaggt ccagggccag tgggaactcc ggacatccct     4560

cttggtacag ctccatccat gccaggccac aaccccatga gaccaccagc ctttctccaa     4620

caaggcatga tgggacctca ccatcggatg atgtcaccag cacaatctac aatgcccggc     4680

cagcccaccc tgatgagcaa tccagctgct gccgtgggca tgattcctgg caaggatcgg     4740

gggcctgccg ggctctacac ccaccctggg cctgtgggct ctccaggcat gatgatgtcc     4800

atgcagggca tgatgggacc ccaacagaac atcatgatcc ccccacagat gaggccccgg     4860

ggcatggctg ctgacgtggg catgggtgga tttagccaag gacctggcaa cccaggaaac     4920

atgatgtttt aagctgctaa gatgggatgt gccgatcctt gtcaagatga gattccaggt     4980

cctgagagct gctttgaggg agttccagga gtacttacta ttggtcatgc aataggagaa     5040

cagagacccg agggctgctt tgggggaggg gggaactcga gaatgtatgg atttacctga     5100

aaacaaatta ttcatttaat caacaggtgt gtttttttta agatttattt tttaaaaatt     5160

atttttgtgg acttgggtat caatgatggc acctactttt gggaatctgt agctgtgctt     5220

tgagaattgc catcggtcat gtgttgcacc gttctctgta tgtttacgtc ctttggactg     5280

gcttctccca ggattctttt ctgtttttgt ttttttgatt tgggctttat ttttttctgt     5340

gtactgtact atattgtaaa agggatttta gcagagactt tagtctttgg ggcaagagga     5400

gaacaggaat gctgggctgt ttactttagg tggagaatcc atcttcagac ctttggacta     5460

ttttctttca actgcagtgt atagaaaaac caaactacga cctcagagca gagtattaat     5520

gaaaagcaca aaaaaaggaa ctaagttcag cgaggggtgg ggggaggggg gagatttttc     5580

ttttgaaaaa taatgactct taggacattt gtttttcagt tcaagtgctc ttcagcactg     5640

tcttgtctcc caatatacca acccactggc acatttttct cttgttttct ctctccgatt     5700

ttgctctgtc tcctcagtta agtgtttcct tcctttgtgc cccccgctgg tgaccctctg     5760

cttccctctc tctttccctt tggcagctgc aatacacagt gttattttgg ggaaataaat     5820

ctagcaaagc ctcgccttcc atgccgagcg tcctcttggc tctgagaggg aaaggtctgt     5880

ccttgggatg ctctctggtc ttttttcccc ctaagtcttt ctctttccca tcataccctt     5940

ccctgcccac cttgttttct gttctccttt tattaggaat tcccaagtga attttattaa     6000

tgtgggagtg gaacagatgc taaaagctat ccaggatttt gtttctgttt gttttaaatt     6060

ttgtggttcc ttccctttcc tccccctccc atgcgtaaga cgttctgtgt aacctccatt     6120

aaatttggta caaaaccact cgccagagct gtggtgtcag aaaaataaaa tatattgttt     6180

cttacaaaat tg                                                         6192


<210>  9
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  9
uguaaacauc cucgacugga ag                                                22


<210>  10
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  10
uguaaacauc cuacacucag cu                                                22


<210>  11
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  11
uguaaacauc cuacacucuc agc                                               23


<210>  12
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  12
uguaaacauc cccgacugga ag                                                22


<210>  13
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  13
uguaaacauc cuugacugaa g                                                 21


<210>  14
<211>  1416
<212>  DNA
<213>  Homo sapiens

<400>  14
atgcagagta ataaaacttt taacttggag aagcaaaacc atactccaag aaagcatcat       60

caacatcacc accagcagca gcaccaccag cagcaacagc agcagccgcc accaccgcca      120

atacctgcaa atgggcaaca ggccagcagc caaaatgaag gcttgactat tgacctgaag      180

aattttagaa aaccaggaga gaagaccttc acccaacgaa gccgtctttt tgtgggaaat      240

cttcctcccg acatcactga ggaagaaatg aggaaactat ttgagaaata tggaaaggca      300

ggcgaagtct tcattcataa ggataaagga tttggcttta tccgcttgga aacccgaacc      360

ctagcggaga ttgccaaagt ggagctggac aatatgccac tccgtggaaa gcagctgcgt      420

gtgcgctttg cctgccatag tgcatccctt acagttcgaa accttcctca gtatgtgtcc      480

aacgaactgc tggaagaagc cttttctgtg tttggccagg tagagagggc tgtagtcatt      540

gtggatgatc gaggaaggcc ctcaggaaaa ggcattgttg agttctcagg gaagccagct      600

gctcggaaag ctctggacag atgcagtgaa ggctccttcc tgctaaccac atttcctcgt      660

cctgtgactg tggagcccat ggaccagtta gatgatgaag agggacttcc agagaagctg      720

gttataaaaa accagcaatt tcacaaggaa cgagagcagc cacccagatt tgcacagcct      780

ggctcctttg agtatgaata tgccatgcgc tggaaggcac tcattgagat ggagaagcag      840

cagcaggacc aagtggaccg caacatcaag gaggctcgtg agaagctgga gatggagatg      900

gaagctgcac gccatgagca ccaggtcatg ctaatgagac aggatttgat gaggcgccaa      960

gaagaacttc ggaggatgga agagctgcac aaccaagagg tgcaaaaacg aaagcaactg     1020

gagctcaggc aggaggaaga gcgcaggcgc cgtgaagaag agatgcggcg gcagcaagaa     1080

gaaatgatgc ggcgacagca ggaaggattc aagggaacct tccctgatgc gagagagcag     1140

gagattcgga tgggtcagat ggctatggga ggtgctatgg gcataaacaa cagaggtgcc     1200

atgccccctg ctcctgtgcc agctggtacc ccagctcctc caggacccgc cactatgatg     1260

ccggatggaa ctttgggatt gaccccacca acaactgaac gctttggtca ggctgctaca     1320

atggaaggaa ttggggcaat tggtggaact cctcctgcat tcaaccgtgc agctcctgga     1380

gctgaatttg ccccaaacaa acgtcgccga tattaa                               1416


<210>  15
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Arg Gly Asp Arg Gly Arg Gly Arg Gly Gly Arg Phe Gly Ser Arg 
1               5                   10                  15      


Gly Gly Pro Gly Gly Gly Phe Arg Pro Phe Val Pro His Ile Pro Phe 
            20                  25                  30          


Asp Phe Tyr Leu Cys Glu Met Ala Phe Pro Arg Val Lys Pro Ala Pro 
        35                  40                  45              


Asp Glu Thr Ser Phe Ser Glu Ala Leu Leu Lys Arg Asn Gln Asp Leu 
    50                  55                  60                  


Ala Pro Asn Ser Ala Glu Gln Ala Ser Ile Leu Ser Leu Val Thr Lys 
65                  70                  75                  80  


Ile Asn Asn Val Ile Asp Asn Leu Ile Val Ala Pro Gly Thr Phe Glu 
                85                  90                  95      


Val Gln Ile Glu Glu Val Arg Gln Val Gly Ser Tyr Lys Lys Gly Thr 
            100                 105                 110         


Met Thr Thr Gly His Asn Val Ala Asp Leu Val Val Ile Leu Lys Ile 
        115                 120                 125             


Leu Pro Thr Leu Glu Ala Val Ala Ala Leu Gly Asn Lys Val Val Glu 
    130                 135                 140                 


Ser Leu Arg Ala Gln Asp Pro Ser Glu Val Leu Thr Met Leu Thr Asn 
145                 150                 155                 160 


Glu Thr Gly Phe Glu Ile Ser Ser Ser Asp Ala Thr Val Lys Ile Leu 
                165                 170                 175     


Ile Thr Thr Val Pro Pro Asn Leu Arg Lys Leu Asp Pro Glu Leu His 
            180                 185                 190         


Leu Asp Ile Lys Val Leu Gln Ser Ala Leu Ala Ala Ile Arg His Ala 
        195                 200                 205             


Arg Trp Phe Glu Glu Asn Ala Ser Gln Ser Thr Val Lys Val Leu Ile 
    210                 215                 220                 


Arg Leu Leu Lys Asp Leu Arg Ile Arg Phe Pro Gly Phe Glu Pro Leu 
225                 230                 235                 240 


Thr Pro Trp Ile Leu Asp Leu Leu Gly His Tyr Ala Val Met Asn Asn 
                245                 250                 255     


Pro Thr Arg Gln Pro Leu Ala Leu Asn Val Ala Tyr Arg Arg Cys Leu 
            260                 265                 270         


Gln Ile Leu Ala Ala Gly Leu Phe Leu Pro Gly Ser Val Gly Ile Thr 
        275                 280                 285             


Asp Pro Cys Glu Ser Gly Asn Phe Arg Val His Thr Val Met Thr Leu 
    290                 295                 300                 


Glu Gln Gln Asp Met Val Cys Tyr Thr Ala Gln Thr Leu Val Arg Ile 
305                 310                 315                 320 


Leu Ser His Gly Gly Phe Arg Lys Ile Leu Gly Gln Glu Gly Asp Ala 
                325                 330                 335     


Ser Tyr Leu Ala Ser Glu Ile Ser Thr Trp Asp Gly Val Ile Val Thr 
            340                 345                 350         


Pro Ser Glu Lys Ala Tyr Glu Lys Pro Pro Glu Lys Lys Glu Gly Glu 
        355                 360                 365             


Glu Glu Glu Glu Asn Thr Glu Glu Pro Pro Gln Gly Glu Glu Glu Glu 
    370                 375                 380                 


Ser Met Glu Thr Gln Glu 
385                 390 


<210>  16
<211>  1852
<212>  DNA
<213>  Homo sapiens

<400>  16
ctcttcagtt gtctgctact cagaggaagg ggcggttggt gcggcctcca ttgttcgtgt       60

tttaaggcgc catgaggggt gacagaggcc gtggtcgtgg tgggcgcttt ggttccagag      120

gaggcccagg aggagggttc aggccctttg taccacatat cccatttgac ttctatttgt      180

gtgaaatggc ctttccccgg gtcaagccag cacctgatga aacttccttc agtgaggcct      240

tgctgaagag gaatcaggac ctggctccca attctgctga acaggcatct atcctttctc      300

tggtgacaaa aataaacaat gtgattgata atctgattgt ggctccaggg acatttgaag      360

tgcaaattga agaagttcga caggtgggat cctataaaaa ggggacaatg actacaggac      420

acaatgtggc tgacctggtg gtgatactca agattctgcc aacgttggaa gctgttgctg      480

ccctggggaa caaagtcgtg gaaagcctaa gagcacagga tccttctgaa gttttaacca      540

tgctgaccaa cgaaactggc tttgaaatca gttcttctga tgctacagtg aagattctca      600

ttacaacagt gccacccaat cttcgaaaac tggatccaga actccatttg gatatcaaag      660

tattgcagag tgccttagca gccatccgac atgcccgctg gttcgaggaa aatgcttctc      720

agtccacagt taaagttctc atcagactac tgaaggactt gaggattcgt tttcctggct      780

ttgagcccct cacaccctgg atccttgacc tactaggcca ttatgctgtg atgaacaacc      840

ccaccagaca gcctttggcc ctaaacgttg catacaggcg ctgcttgcag attctggctg      900

caggactgtt cctgccaggt tcagtgggta tcactgaccc ctgtgagagt ggcaacttta      960

gagtacacac agtcatgacc ctagaacagc aggacatggt ctgctataca gctcagactc     1020

tcgtccgaat cctctcacat ggtggcttta ggaagatcct tggccaggag ggtgatgcca     1080

gctatcttgc ttctgaaata tctacctggg atggagtgat agtaacacct tcagaaaagg     1140

cttatgagaa gccaccagag aagaaggaag gagaggaaga agaggagaat acagaagaac     1200

cacctcaagg agaggaagaa gaaagcatgg aaactcagga gtgacattcc cttcactcct     1260

tttcctaccc aagggggaag actggagcct aagctgcctg ctactgggct ttacatggtg     1320

acagacattt ccgtgggata gggaagatag caggaagaaa agtaaactcc atagaagtgt     1380

cattccactg ggttttgata ttggcttagc tgccagtctc ccatttgtga cctatgccat     1440

ccatctataa tggaggatac caacatttct tcctaatatt ctataatctc caactcctga     1500

aaacccctct ctcaactaat actttgctgt tgaaatgttg tgaaatgtta agtgtctgga     1560

aatttttttt tctaagaaaa actattaaag tacttcctag tagggctctt ggtctttctg     1620

gttggtgttt tttgtttgtt tgtttttttg catgtggcaa ccttttttgc ttttggcttt     1680

gtgtactctt ttgttgaaaa tgataattga gtcatttaat tataaatact cagatcacaa     1740

tttgaagctg tctttgaatt aaaggacaaa ctcctggaac ctttccatat accagagtaa     1800

actagaatat cattttaagt atttattgaa taaaatgatt ctatcaacac tg             1852


<210>  17
<211>  707
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ser Arg Asp Arg Phe Arg Ser Arg Gly Gly Gly Gly Gly Gly Phe 
1               5                   10                  15      


His Arg Arg Gly Gly Gly Gly Gly Arg Gly Gly Leu His Asp Phe Arg 
            20                  25                  30          


Ser Pro Pro Pro Gly Met Gly Leu Asn Gln Asn Arg Gly Pro Met Gly 
        35                  40                  45              


Pro Gly Pro Gly Gln Ser Gly Pro Lys Pro Pro Ile Pro Pro Pro Pro 
    50                  55                  60                  


Pro His Gln Gln Gln Gln Gln Pro Pro Pro Gln Gln Pro Pro Pro Gln 
65                  70                  75                  80  


Gln Pro Pro Pro His Gln Pro Pro Pro His Pro Gln Pro His Gln Gln 
                85                  90                  95      


Gln Gln Pro Pro Pro Pro Pro Gln Asp Ser Ser Lys Pro Val Val Ala 
            100                 105                 110         


Gln Gly Pro Gly Pro Ala Pro Gly Val Gly Ser Ala Pro Pro Ala Ser 
        115                 120                 125             


Ser Ser Ala Pro Pro Ala Thr Pro Pro Thr Ser Gly Ala Pro Pro Gly 
    130                 135                 140                 


Ser Gly Pro Gly Pro Thr Pro Thr Pro Pro Pro Ala Val Thr Ser Ala 
145                 150                 155                 160 


Pro Pro Gly Ala Pro Pro Pro Thr Pro Pro Ser Ser Gly Val Pro Thr 
                165                 170                 175     


Thr Pro Pro Gln Ala Gly Gly Pro Pro Pro Pro Pro Ala Ala Val Pro 
            180                 185                 190         


Gly Pro Gly Pro Gly Pro Lys Gln Gly Pro Gly Pro Gly Gly Pro Lys 
        195                 200                 205             


Gly Gly Lys Met Pro Gly Gly Pro Lys Pro Gly Gly Gly Pro Gly Leu 
    210                 215                 220                 


Ser Thr Pro Gly Gly His Pro Lys Pro Pro His Arg Gly Gly Gly Glu 
225                 230                 235                 240 


Pro Arg Gly Gly Arg Gln His His Pro Pro Tyr His Gln Gln His His 
                245                 250                 255     


Gln Gly Pro Pro Pro Gly Gly Pro Gly Gly Arg Ser Glu Glu Lys Ile 
            260                 265                 270         


Ser Asp Ser Glu Gly Phe Lys Ala Asn Leu Ser Leu Leu Arg Arg Pro 
        275                 280                 285             


Gly Glu Lys Thr Tyr Thr Gln Arg Cys Arg Leu Phe Val Gly Asn Leu 
    290                 295                 300                 


Pro Ala Asp Ile Thr Glu Asp Glu Phe Lys Arg Leu Phe Ala Lys Tyr 
305                 310                 315                 320 


Gly Glu Pro Gly Glu Val Phe Ile Asn Lys Gly Lys Gly Phe Gly Phe 
                325                 330                 335     


Ile Lys Leu Glu Ser Arg Ala Leu Ala Glu Ile Ala Lys Ala Glu Leu 
            340                 345                 350         


Asp Asp Thr Pro Met Arg Gly Arg Gln Leu Arg Val Arg Phe Ala Thr 
        355                 360                 365             


His Ala Ala Ala Leu Ser Val Arg Asn Leu Ser Pro Tyr Val Ser Asn 
    370                 375                 380                 


Glu Leu Leu Glu Glu Ala Phe Ser Gln Phe Gly Pro Ile Glu Arg Ala 
385                 390                 395                 400 


Val Val Ile Val Asp Asp Arg Gly Arg Ser Thr Gly Lys Gly Ile Val 
                405                 410                 415     


Glu Phe Ala Ser Lys Pro Ala Ala Arg Lys Ala Phe Glu Arg Cys Ser 
            420                 425                 430         


Glu Gly Val Phe Leu Leu Thr Thr Thr Pro Arg Pro Val Ile Val Glu 
        435                 440                 445             


Pro Leu Glu Gln Leu Asp Asp Glu Asp Gly Leu Pro Glu Lys Leu Ala 
    450                 455                 460                 


Gln Lys Asn Pro Met Tyr Gln Lys Glu Arg Glu Thr Pro Pro Arg Phe 
465                 470                 475                 480 


Ala Gln His Gly Thr Phe Glu Tyr Glu Tyr Ser Gln Arg Trp Lys Ser 
                485                 490                 495     


Leu Asp Glu Met Glu Lys Gln Gln Arg Glu Gln Val Glu Lys Asn Met 
            500                 505                 510         


Lys Asp Ala Lys Asp Lys Leu Glu Ser Glu Met Glu Asp Ala Tyr His 
        515                 520                 525             


Glu His Gln Ala Asn Leu Leu Arg Gln Asp Leu Met Arg Arg Gln Glu 
    530                 535                 540                 


Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Met Gln Lys Arg 
545                 550                 555                 560 


Lys Glu Met Gln Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu Glu 
                565                 570                 575     


Glu Met Met Ile Arg Gln Arg Glu Met Glu Glu Gln Met Arg Arg Gln 
            580                 585                 590         


Arg Glu Glu Ser Tyr Ser Arg Met Gly Tyr Met Asp Pro Arg Glu Arg 
        595                 600                 605             


Asp Met Arg Met Gly Gly Gly Gly Ala Met Asn Met Gly Asp Pro Tyr 
    610                 615                 620                 


Gly Ser Gly Gly Gln Lys Phe Pro Pro Leu Gly Gly Gly Gly Gly Ile 
625                 630                 635                 640 


Gly Tyr Glu Ala Asn Pro Gly Val Pro Pro Ala Thr Met Ser Gly Ser 
                645                 650                 655     


Met Met Gly Ser Asp Met Arg Thr Glu Arg Phe Gly Gln Gly Gly Ala 
            660                 665                 670         


Gly Pro Val Gly Gly Gln Gly Pro Arg Gly Met Gly Pro Gly Thr Pro 
        675                 680                 685             


Ala Gly Tyr Gly Arg Gly Arg Glu Glu Tyr Glu Gly Pro Asn Lys Lys 
    690                 695                 700                 


Pro Arg Phe 
705         


<210>  18
<211>  3740
<212>  DNA
<213>  Homo sapiens

<400>  18
gcctgtgtca tccgccattt tgtgagaagc aaggtggcct ccacgtttcc tgagcgtctt       60

cttcgctttt gcctcgaccg ccccttgacc acagacatgt ctcgggatcg gttccggagt      120

cgtggcggtg gcggtggtgg cttccacagg cgtggaggag gcggcggccg cggcggcctc      180

cacgacttcc gttctccgcc gcccggcatg ggcctcaatc agaatcgcgg ccccatgggt      240

cctggcccgg gccagagcgg ccctaagcct ccgatcccgc caccgcctcc acaccaacag      300

cagcaacagc caccaccgca gcagccaccg ccgcagcagc cgccaccgca tcagccgccg      360

ccgcatccac agccgcatca gcagcagcag ccgccgccac cgccgcagga ctcttccaag      420

cccgtcgttg ctcagggacc cggccccgct cccggagtag gcagcgcacc accagcctcc      480

agctcggccc cgcccgccac tccaccaacc tcgggggccc cgccagggtc cgggccaggc      540

ccgactccga ccccgccgcc tgcagtcacc tcggcccctc ccggggcgcc gccacccacc      600

ccgccaagca gcggggtccc taccacacct cctcaggccg gaggcccgcc gcctccgccc      660

gcggcagtcc cgggcccggg tccagggcct aagcagggcc caggtccggg tggtcccaaa      720

ggcggcaaaa tgcctggcgg gccgaagcca ggtggcggcc cgggcctaag tacgcctggc      780

ggccacccca agccgccgca tcgaggcggc ggggagcccc gcgggggccg ccagcaccac      840

ccgccctacc accagcagca tcaccagggg cccccgcccg gcgggcccgg cggccgcagc      900

gaggagaaga tctcggactc ggaggggttt aaagccaatt tgtctctctt gaggaggcct      960

ggagagaaaa cttacacaca gcgatgtcgg ttgtttgttg ggaatctacc tgctgatatc     1020

acggaggatg aattcaaaag actatttgct aaatatggag aaccaggaga agtttttatc     1080

aacaaaggca aaggattcgg atttattaag cttgaatcta gagctttggc tgaaattgcc     1140

aaagccgaac tggatgatac acccatgaga ggtagacagc ttcgagttcg ctttgccaca     1200

catgctgctg ccctttctgt tcgtaatctt tcaccttatg tttccaatga actgttggaa     1260

gaagccttta gccaatttgg tcctattgaa agggctgttg taatagtgga tgatcgtgga     1320

agatctacag ggaaaggcat tgttgaattt gcttctaagc cagcagcaag aaaggcattt     1380

gaacgatgca gtgaaggtgt tttcttactg acgacaactc ctcgtccagt cattgtggaa     1440

ccacttgaac aactagatga tgaagatggt cttcctgaaa aacttgccca gaagaatcca     1500

atgtatcaaa aggagagaga aacccctcct cgttttgccc agcatggcac gtttgagtac     1560

gaatattctc agcgatggaa gtctttggat gaaatggaaa aacagcaaag ggaacaagtt     1620

gaaaaaaaca tgaaagatgc aaaagacaaa ttggaaagtg aaatggaaga tgcctatcat     1680

gaacatcagg caaatctttt gcgccaagat ctgatgagac gacaggaaga attaagacgc     1740

atggaagaac ttcacaatca agaaatgcag aaacgtaaag aaatgcaatt gaggcaagag     1800

gaggaacgac gtagaagaga ggaagagatg atgattcgtc aacgtgagat ggaagaacaa     1860

atgaggcgcc aaagagagga aagttacagc cgaatgggct acatggatcc acgggaaaga     1920

gacatgcgaa tgggtggcgg aggagcaatg aacatgggag atccctatgg ttcaggaggc     1980

cagaaatttc cacctctagg aggtggtggt ggcataggtt atgaagctaa tcctggcgtt     2040

ccaccagcaa ccatgagtgg ttccatgatg ggaagtgaca tgcgtactga gcgctttggg     2100

cagggaggtg cggggcctgt gggtggacag ggtcctagag gaatggggcc tggaactcca     2160

gcaggatatg gtagagggag agaagagtac gaaggcccaa acaaaaaacc ccgattttag     2220

atgtgatatt taggctttca ttccagtttg ttttgttttt ttgtttagat accaatcttt     2280

taaattcttg cattttagta agaaagctat ctttttatgg atgttagcag tttattgacc     2340

taatatttgt aaatggtctg tttgggcagg taaaattatg taatgcagtg tttggaacag     2400

gagaattttt ttttcctttt tatttcttta ttttttcttt tttactgtat aatgtccctc     2460

aagtttatgg cagtgtacct tgtgccactg aatttccaaa gtgtaccaat tttttttttt     2520

ttactgtgct tcaaataaat agaaaaatag ttataatatt gatcttcaac tttgccattc     2580

atgcttctat gcatattagg ctacgtattc cacattgaaa gcatgagagt gtctaggcct     2640

ttgaatggca tatgccattt ctgggaaatg catctggagg ctaagtattg ctttctacaa     2700

ataattgccc cctttgtttt aaaaagaaga aatgcatatt gaagtagttt gatgatttgt     2760

ttggcatata ggaagcacgc tggtgctaag tattttttaa atggttatgt aagcaaagct     2820

gaactgtaaa tcttcaggaa tatgtattaa gattgtggaa tgggtgtaag acaattggta     2880

gggggtgaaa gtgggtttga ttaaatggat cttttatggc cctatgatct atcctttact     2940

tgaaagcttt tgaaaagtgg aaaggtcatt ttgttgcatt tccccatttc ttgtttttaa     3000

aagaccaaca aatctcaagc cctataaatg gcttgtattg aacttttaca tttgaattaa     3060

agatgttaaa catgaagtct tttcatgtat tcaagtgatt tataaagatg gggtgtagtc     3120

taaaaaacaa aacttgaaag taagaaggtt tagtaactgg gccgggcgcg gtggctcacg     3180

cctgtaatcc cagcactttg ggaggctgag gtgggcaaat catgagatca ggagttcaag     3240

accagcctgg ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa attagctggg     3300

cgtggtggca ggcgcctgta atcccagcta ctcgggaggc tgagccagga gaattgcttg     3360

aacctggaga tggaggttgc agtgagctga gactgccact gcactccagc ctggacaaca     3420

gagcgagact ctgtctcaaa aaaaaaaaaa ggtttagtac tgaagtaggt ttagttatat     3480

atacatttgt actctgtaac ttttacatct ccttgtgcta cttctgttgg gcaaaatcta     3540

taggactata aaaatctatt ggttctcttc taagagctag tggtgattgt taacaaatag     3600

ggttgcagat aatcattctt attgtaaatt taacttgttt tcacatagtt tcgttttcat     3660

gtagcactaa atctggagaa agttgctcat gctacacagt acaaatatcc cttcctccca     3720

ccataaaggc ttggaatgtt                                                 3740


<210>  19
<211>  806
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Ser Gly Ala Asp Ser Lys Gly Asp Asp Leu Ser Thr Ala Ile 
1               5                   10                  15      


Leu Lys Gln Lys Asn Arg Pro Asn Arg Leu Ile Val Asp Glu Ala Ile 
            20                  25                  30          


Asn Glu Asp Asn Ser Val Val Ser Leu Ser Gln Pro Lys Met Asp Glu 
        35                  40                  45              


Leu Gln Leu Phe Arg Gly Asp Thr Val Leu Leu Lys Gly Lys Lys Arg 
    50                  55                  60                  


Arg Glu Ala Val Cys Ile Val Leu Ser Asp Asp Thr Cys Ser Asp Glu 
65                  70                  75                  80  


Lys Ile Arg Met Asn Arg Val Val Arg Asn Asn Leu Arg Val Arg Leu 
                85                  90                  95      


Gly Asp Val Ile Ser Ile Gln Pro Cys Pro Asp Val Lys Tyr Gly Lys 
            100                 105                 110         


Arg Ile His Val Leu Pro Ile Asp Asp Thr Val Glu Gly Ile Thr Gly 
        115                 120                 125             


Asn Leu Phe Glu Val Tyr Leu Lys Pro Tyr Phe Leu Glu Ala Tyr Arg 
    130                 135                 140                 


Pro Ile Arg Lys Gly Asp Ile Phe Leu Val Arg Gly Gly Met Arg Ala 
145                 150                 155                 160 


Val Glu Phe Lys Val Val Glu Thr Asp Pro Ser Pro Tyr Cys Ile Val 
                165                 170                 175     


Ala Pro Asp Thr Val Ile His Cys Glu Gly Glu Pro Ile Lys Arg Glu 
            180                 185                 190         


Asp Glu Glu Glu Ser Leu Asn Glu Val Gly Tyr Asp Asp Ile Gly Gly 
        195                 200                 205             


Cys Arg Lys Gln Leu Ala Gln Ile Lys Glu Met Val Glu Leu Pro Leu 
    210                 215                 220                 


Arg His Pro Ala Leu Phe Lys Ala Ile Gly Val Lys Pro Pro Arg Gly 
225                 230                 235                 240 


Ile Leu Leu Tyr Gly Pro Pro Gly Thr Gly Lys Thr Leu Ile Ala Arg 
                245                 250                 255     


Ala Val Ala Asn Glu Thr Gly Ala Phe Phe Phe Leu Ile Asn Gly Pro 
            260                 265                 270         


Glu Ile Met Ser Lys Leu Ala Gly Glu Ser Glu Ser Asn Leu Arg Lys 
        275                 280                 285             


Ala Phe Glu Glu Ala Glu Lys Asn Ala Pro Ala Ile Ile Phe Ile Asp 
    290                 295                 300                 


Glu Leu Asp Ala Ile Ala Pro Lys Arg Glu Lys Thr His Gly Glu Val 
305                 310                 315                 320 


Glu Arg Arg Ile Val Ser Gln Leu Leu Thr Leu Met Asp Gly Leu Lys 
                325                 330                 335     


Gln Arg Ala His Val Ile Val Met Ala Ala Thr Asn Arg Pro Asn Ser 
            340                 345                 350         


Ile Asp Pro Ala Leu Arg Arg Phe Gly Arg Phe Asp Arg Glu Val Asp 
        355                 360                 365             


Ile Gly Ile Pro Asp Ala Thr Gly Arg Leu Glu Ile Leu Gln Ile His 
    370                 375                 380                 


Thr Lys Asn Met Lys Leu Ala Asp Asp Val Asp Leu Glu Gln Val Ala 
385                 390                 395                 400 


Asn Glu Thr His Gly His Val Gly Ala Asp Leu Ala Ala Leu Cys Ser 
                405                 410                 415     


Glu Ala Ala Leu Gln Ala Ile Arg Lys Lys Met Asp Leu Ile Asp Leu 
            420                 425                 430         


Glu Asp Glu Thr Ile Asp Ala Glu Val Met Asn Ser Leu Ala Val Thr 
        435                 440                 445             


Met Asp Asp Phe Arg Trp Ala Leu Ser Gln Ser Asn Pro Ser Ala Leu 
    450                 455                 460                 


Arg Glu Thr Val Val Glu Val Pro Gln Val Thr Trp Glu Asp Ile Gly 
465                 470                 475                 480 


Gly Leu Glu Asp Val Lys Arg Glu Leu Gln Glu Leu Val Gln Tyr Pro 
                485                 490                 495     


Val Glu His Pro Asp Lys Phe Leu Lys Phe Gly Met Thr Pro Ser Lys 
            500                 505                 510         


Gly Val Leu Phe Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala 
        515                 520                 525             


Lys Ala Ile Ala Asn Glu Cys Gln Ala Asn Phe Ile Ser Ile Lys Gly 
    530                 535                 540                 


Pro Glu Leu Leu Thr Met Trp Phe Gly Glu Ser Glu Ala Asn Val Arg 
545                 550                 555                 560 


Glu Ile Phe Asp Lys Ala Arg Gln Ala Ala Pro Cys Val Leu Phe Phe 
                565                 570                 575     


Asp Glu Leu Asp Ser Ile Ala Lys Ala Arg Gly Gly Asn Ile Gly Asp 
            580                 585                 590         


Gly Gly Gly Ala Ala Asp Arg Val Ile Asn Gln Ile Leu Thr Glu Met 
        595                 600                 605             


Asp Gly Met Ser Thr Lys Lys Asn Val Phe Ile Ile Gly Ala Thr Asn 
    610                 615                 620                 


Arg Pro Asp Ile Ile Asp Pro Ala Ile Leu Arg Pro Gly Arg Leu Asp 
625                 630                 635                 640 


Gln Leu Ile Tyr Ile Pro Leu Pro Asp Glu Lys Ser Arg Val Ala Ile 
                645                 650                 655     


Leu Lys Ala Asn Leu Arg Lys Ser Pro Val Ala Lys Asp Val Asp Leu 
            660                 665                 670         


Glu Phe Leu Ala Lys Met Thr Asn Gly Phe Ser Gly Ala Asp Leu Thr 
        675                 680                 685             


Glu Ile Cys Gln Arg Ala Cys Lys Leu Ala Ile Arg Glu Ser Ile Glu 
    690                 695                 700                 


Ser Glu Ile Arg Arg Glu Arg Glu Arg Gln Thr Asn Pro Ser Ala Met 
705                 710                 715                 720 


Glu Val Glu Glu Asp Asp Pro Val Pro Glu Ile Arg Arg Asp His Phe 
                725                 730                 735     


Glu Glu Ala Met Arg Phe Ala Arg Arg Ser Val Ser Asp Asn Asp Ile 
            740                 745                 750         


Arg Lys Tyr Glu Met Phe Ala Gln Thr Leu Gln Gln Ser Arg Gly Phe 
        755                 760                 765             


Gly Ser Phe Arg Phe Pro Ser Gly Asn Gln Gly Gly Ala Gly Pro Ser 
    770                 775                 780                 


Gln Gly Ser Gly Gly Gly Thr Gly Gly Ser Val Tyr Thr Glu Asp Asn 
785                 790                 795                 800 


Asp Asp Asp Leu Tyr Gly 
                805     


<210>  20
<211>  3743
<212>  DNA
<213>  Homo sapiens

<400>  20
agtctcagcg aagcgtctgc gaccgtcgtt tgagtcgtcg ctgccgctgc cgctgccact       60

gccactgcca cctcgcggat caggagccag cgttgttcgc ccgacgcctc gctgccggtg      120

ggaggaagcg agagggaagc cgcttgcggg tttgtcgccg ctgctcgccc accgcctgga      180

agagccgagc cccggcccag tcggtcgctt gccaccgctc gtagccgtta cccgcgggcc      240

gccacagccg ccggccggga gaggcgcgcg ccatggcttc tggagccgat tcaaaaggtg      300

atgacctatc aacagccatt ctcaaacaga agaaccgtcc caatcggtta attgttgatg      360

aagccatcaa tgaggacaac agtgtggtgt ccttgtccca gcccaagatg gatgaattgc      420

agttgttccg aggtgacaca gtgttgctga aaggaaagaa gagacgagaa gctgtttgca      480

tcgtcctttc tgatgatact tgttctgatg agaagattcg gatgaataga gttgttcgga      540

ataaccttcg tgtacgccta ggggatgtca tcagcatcca gccatgccct gatgtgaagt      600

acggcaaacg tatccatgtg ctgcccattg atgacacagt ggaaggcatt actggtaatc      660

tcttcgaggt ataccttaag ccgtacttcc tggaagcgta tcgacccatc cggaaaggag      720

acatttttct tgtccgtggt gggatgcgtg ctgtggagtt caaagtggtg gaaacagatc      780

ctagccctta ttgcattgtt gctccagaca cagtgatcca ctgcgaaggg gagcctatca      840

aacgagagga tgaggaagag tccttgaatg aagtagggta tgatgacatt ggtggctgca      900

ggaagcagct agctcagata aaggagatgg tggaactgcc cctgagacat cctgccctct      960

ttaaggcaat tggtgtgaag cctcctagag gaatcctgct ttacggacct cctggaacag     1020

gaaagaccct gattgctcga gctgtagcaa atgagactgg agccttcttc ttcttgatca     1080

atggtcctga gatcatgagc aaattggctg gtgagtctga gagcaacctt cgtaaagcct     1140

ttgaggaggc tgagaagaat gctcctgcca tcatcttcat tgatgagcta gatgccatcg     1200

ctcccaaaag agagaaaact catggcgagg tggagcggcg cattgtatca cagttgttga     1260

ccctcatgga tggcctaaag cagagggcac atgtgattgt tatggcagca accaacagac     1320

ccaacagcat tgacccagct ctacggcgat ttggtcgctt tgacagggag gtagatattg     1380

gaattcctga tgctacagga cgcttagaga ttcttcagat ccataccaag aacatgaagc     1440

tggcagatga tgtggacctg gaacaggtag ccaatgagac tcacgggcat gtgggtgctg     1500

acttagcagc cctgtgctca gaggctgctc tgcaagccat ccgcaagaag atggatctca     1560

ttgacctaga ggatgagacc attgatgccg aggtcatgaa ctctctagca gttactatgg     1620

atgacttccg gtgggccttg agccagagta acccatcagc actgcgggaa accgtggtag     1680

aggtgccaca ggtaacctgg gaagacatcg ggggcctaga ggatgtcaaa cgtgagctac     1740

aggagctggt ccagtatcct gtggagcacc cagacaaatt cctgaagttt ggcatgacac     1800

cttccaaggg agttctgttc tatggacctc ctggctgtgg gaaaactttg ttggccaaag     1860

ccattgctaa tgaatgccag gccaacttca tctccatcaa gggtcctgag ctgctcacca     1920

tgtggtttgg ggagtctgag gccaatgtca gagaaatctt tgacaaggcc cgccaagctg     1980

ccccctgtgt gctattcttt gatgagctgg attcgattgc caaggctcgt ggaggtaaca     2040

ttggagatgg tggtggggct gctgaccgag tcatcaacca gatcctgaca gaaatggatg     2100

gcatgtccac aaaaaaaaat gtgttcatca ttggcgctac caaccggcct gacatcattg     2160

atcctgccat cctcagacct ggccgtcttg atcagctcat ctacatccca cttcctgatg     2220

agaagtcccg tgttgccatc ctcaaggcta acctgcgcaa gtccccagtt gccaaggatg     2280

tggacttgga gttcctggct aaaatgacta atggcttctc tggagctgac ctgacagaga     2340

tttgccagcg tgcttgcaag ctggccatcc gtgaatccat cgagagtgag attaggcgag     2400

aacgagagag gcagacaaac ccatcagcca tggaggtaga agaggatgat ccagtgcctg     2460

agatccgtcg agatcacttt gaagaagcca tgcgctttgc gcgccgttct gtcagtgaca     2520

atgacattcg gaagtatgag atgtttgccc agacccttca gcagagtcgg ggctttggca     2580

gcttcagatt cccttcaggg aaccagggtg gagctggccc cagtcagggc agtggaggcg     2640

gcacaggtgg cagtgtatac acagaagaca atgatgatga cctgtatggc taagtggtgg     2700

tggccagcgt gcagtgagct ggcctgcctg gaccttgttc cctgggggtg ggggcgcttg     2760

cccaggagag ggaccagggg tgcgcccaca gcctgctcca ttctccagtc tgaacagttc     2820

agctacagtc tgactctgga cagggggttt ctgttgcaaa aatacaaaac aaaagcgata     2880

aaataaaagc gattttcatt tggtaggcgg agagtgaatt accaacaggg aattgggcct     2940

tgggcctatg ccatttctgt tgtagtttgg ggcagtgcag gggacctgtg tggggtgtga     3000

accaaggcac tactgccacc tgccacagta aagcatctgc acttgactca atgctgcccg     3060

agccctccct tccccctatc caacctgggt aggtgggtag gggccacagt tgctggatgt     3120

ttatatagag agtaggttga tttattttac atgcttttga gttaatgttg gaaaactaat     3180

cacaagcagt ttctaaacca aaaaatgaca tgttgtaaaa ggacaataaa cgttgggtca     3240

aaatggagcc tgagtcctgg gccctgtgcc tgcttctttt cctgggaaca gccttgggct     3300

acccaccact cccaaggcat tcttccaaat gtgaaatcct ggaagtaaga ttgcaccttc     3360

ttcctctcct gatcaacatc ggtatgatgt ctcctgttgc ctcacccttt gtctgcagta     3420

tcactggata ggactggtgg aaagggagca gcctgacaga gctccaaatg tggagaatat     3480

ggcatccctc cacctatatt tgatgtggac ggtaaggcta ggcctgcagg atcccttatc     3540

ctgaccaaag actgtgttgg ggtgccattt gaaaatcgca gggttgcaaa agaatacaat     3600

cttacttgca ggtggatatt ctctatactc tcttttaatg catctaaaaa tcccaaacat     3660

cccctggttg gtgatcactt acagttgtgt ccacctttat tttatgtact ttgattaaaa     3720

aaaaactttt tgttaatata aaa                                             3743


<210>  21
<211>  760
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Lys Thr Trp Val Lys Ile Val Phe Gly Val Ala Thr Ser Ala Val 
1               5                   10                  15      


Leu Ala Leu Leu Val Met Cys Ile Val Leu Arg Pro Ser Arg Val His 
            20                  25                  30          


Asn Ser Glu Glu Asn Thr Met Arg Ala Leu Thr Leu Lys Asp Ile Leu 
        35                  40                  45              


Asn Gly Thr Phe Ser Tyr Lys Thr Phe Phe Pro Asn Trp Ile Ser Gly 
    50                  55                  60                  


Gln Glu Tyr Leu His Gln Ser Ala Asp Asn Asn Ile Val Leu Tyr Asn 
65                  70                  75                  80  


Ile Glu Thr Gly Gln Ser Tyr Thr Ile Leu Ser Asn Arg Thr Met Lys 
                85                  90                  95      


Ser Val Asn Ala Ser Asn Tyr Gly Leu Ser Pro Asp Arg Gln Phe Val 
            100                 105                 110         


Tyr Leu Glu Ser Asp Tyr Ser Lys Leu Trp Arg Tyr Ser Tyr Thr Ala 
        115                 120                 125             


Thr Tyr Tyr Ile Tyr Asp Leu Ser Asn Gly Glu Phe Val Arg Gly Asn 
    130                 135                 140                 


Glu Leu Pro Arg Pro Ile Gln Tyr Leu Cys Trp Ser Pro Val Gly Ser 
145                 150                 155                 160 


Lys Leu Ala Tyr Val Tyr Gln Asn Asn Ile Tyr Leu Lys Gln Arg Pro 
                165                 170                 175     


Gly Asp Pro Pro Phe Gln Ile Thr Phe Asn Gly Arg Glu Asn Lys Ile 
            180                 185                 190         


Phe Asn Gly Ile Pro Asp Trp Val Tyr Glu Glu Glu Met Leu Ala Thr 
        195                 200                 205             


Lys Tyr Ala Leu Trp Trp Ser Pro Asn Gly Lys Phe Leu Ala Tyr Ala 
    210                 215                 220                 


Glu Phe Asn Asp Thr Asp Ile Pro Val Ile Ala Tyr Ser Tyr Tyr Gly 
225                 230                 235                 240 


Asp Glu Gln Tyr Pro Arg Thr Ile Asn Ile Pro Tyr Pro Lys Ala Gly 
                245                 250                 255     


Ala Lys Asn Pro Val Val Arg Ile Phe Ile Ile Asp Thr Thr Tyr Pro 
            260                 265                 270         


Ala Tyr Val Gly Pro Gln Glu Val Pro Val Pro Ala Met Ile Ala Ser 
        275                 280                 285             


Ser Asp Tyr Tyr Phe Ser Trp Leu Thr Trp Val Thr Asp Glu Arg Val 
    290                 295                 300                 


Cys Leu Gln Trp Leu Lys Arg Val Gln Asn Val Ser Val Leu Ser Ile 
305                 310                 315                 320 


Cys Asp Phe Arg Glu Asp Trp Gln Thr Trp Asp Cys Pro Lys Thr Gln 
                325                 330                 335     


Glu His Ile Glu Glu Ser Arg Thr Gly Trp Ala Gly Gly Phe Phe Val 
            340                 345                 350         


Ser Thr Pro Val Phe Ser Tyr Asp Ala Ile Ser Tyr Tyr Lys Ile Phe 
        355                 360                 365             


Ser Asp Lys Asp Gly Tyr Lys His Ile His Tyr Ile Lys Asp Thr Val 
    370                 375                 380                 


Glu Asn Ala Ile Gln Ile Thr Ser Gly Lys Trp Glu Ala Ile Asn Ile 
385                 390                 395                 400 


Phe Arg Val Thr Gln Asp Ser Leu Phe Tyr Ser Ser Asn Glu Phe Glu 
                405                 410                 415     


Glu Tyr Pro Gly Arg Arg Asn Ile Tyr Arg Ile Ser Ile Gly Ser Tyr 
            420                 425                 430         


Pro Pro Ser Lys Lys Cys Val Thr Cys His Leu Arg Lys Glu Arg Cys 
        435                 440                 445             


Gln Tyr Tyr Thr Ala Ser Phe Ser Asp Tyr Ala Lys Tyr Tyr Ala Leu 
    450                 455                 460                 


Val Cys Tyr Gly Pro Gly Ile Pro Ile Ser Thr Leu His Asp Gly Arg 
465                 470                 475                 480 


Thr Asp Gln Glu Ile Lys Ile Leu Glu Glu Asn Lys Glu Leu Glu Asn 
                485                 490                 495     


Ala Leu Lys Asn Ile Gln Leu Pro Lys Glu Glu Ile Lys Lys Leu Glu 
            500                 505                 510         


Val Asp Glu Ile Thr Leu Trp Tyr Lys Met Ile Leu Pro Pro Gln Phe 
        515                 520                 525             


Asp Arg Ser Lys Lys Tyr Pro Leu Leu Ile Gln Val Tyr Gly Gly Pro 
    530                 535                 540                 


Cys Ser Gln Ser Val Arg Ser Val Phe Ala Val Asn Trp Ile Ser Tyr 
545                 550                 555                 560 


Leu Ala Ser Lys Glu Gly Met Val Ile Ala Leu Val Asp Gly Arg Gly 
                565                 570                 575     


Thr Ala Phe Gln Gly Asp Lys Leu Leu Tyr Ala Val Tyr Arg Lys Leu 
            580                 585                 590         


Gly Val Tyr Glu Val Glu Asp Gln Ile Thr Ala Val Arg Lys Phe Ile 
        595                 600                 605             


Glu Met Gly Phe Ile Asp Glu Lys Arg Ile Ala Ile Trp Gly Trp Ser 
    610                 615                 620                 


Tyr Gly Gly Tyr Val Ser Ser Leu Ala Leu Ala Ser Gly Thr Gly Leu 
625                 630                 635                 640 


Phe Lys Cys Gly Ile Ala Val Ala Pro Val Ser Ser Trp Glu Tyr Tyr 
                645                 650                 655     


Ala Ser Val Tyr Thr Glu Arg Phe Met Gly Leu Pro Thr Lys Asp Asp 
            660                 665                 670         


Asn Leu Glu His Tyr Lys Asn Ser Thr Val Met Ala Arg Ala Glu Tyr 
        675                 680                 685             


Phe Arg Asn Val Asp Tyr Leu Leu Ile His Gly Thr Ala Asp Asp Asn 
    690                 695                 700                 


Val His Phe Gln Asn Ser Ala Gln Ile Ala Lys Ala Leu Val Asn Ala 
705                 710                 715                 720 


Gln Val Asp Phe Gln Ala Met Trp Tyr Ser Asp Gln Asn His Gly Leu 
                725                 730                 735     


Ser Gly Leu Ser Thr Asn His Leu Tyr Thr His Met Thr His Phe Leu 
            740                 745                 750         


Lys Gln Cys Phe Ser Leu Ser Asp 
        755                 760 


<210>  22
<211>  2696
<212>  DNA
<213>  Homo sapiens

<400>  22
gtcctggctt cagcttccaa ctacaaagac agacttggtc cttttcaacg gttttcacag       60

atccagtgac ccacgctctg aagacagaat tagctaactt tcaaaaacat ctggaaaaat      120

gaagacttgg gtaaaaatcg tatttggagt tgccacctct gctgtgcttg ccttattggt      180

gatgtgcatt gtcttacgcc cttcaagagt tcataactct gaagaaaata caatgagagc      240

actcacactg aaggatattt taaatggaac attttcttat aaaacatttt ttccaaactg      300

gatttcagga caagaatatc ttcatcaatc tgcagataac aatatagtac tttataatat      360

tgaaacagga caatcatata ccattttgag taatagaacc atgaaaagtg tgaatgcttc      420

aaattacggc ttatcacctg atcggcaatt tgtatatcta gaaagtgatt attcaaagct      480

ttggagatac tcttacacag caacatatta catctatgac cttagcaatg gagaatttgt      540

aagaggaaat gagcttcctc gtccaattca gtatttatgc tggtcgcctg ttgggagtaa      600

attagcatat gtctatcaaa acaatatcta tttgaaacaa agaccaggag atccaccttt      660

tcaaataaca tttaatggaa gagaaaataa aatatttaat ggaatcccag actgggttta      720

tgaagaggaa atgcttgcta caaaatatgc tctctggtgg tctcctaatg gaaaattttt      780

ggcatatgcg gaatttaatg atacggatat accagttatt gcctattcct attatggcga      840

tgaacaatat cctagaacaa taaatattcc atacccaaag gctggagcta agaatcccgt      900

tgttcggata tttattatcg ataccactta ccctgcgtat gtaggtcccc aggaagtgcc      960

tgttccagca atgatagcct caagtgatta ttatttcagt tggctcacgt gggttactga     1020

tgaacgagta tgtttgcagt ggctaaaaag agtccagaat gtttcggtcc tgtctatatg     1080

tgacttcagg gaagactggc agacatggga ttgtccaaag acccaggagc atatagaaga     1140

aagcagaact ggatgggctg gtggattctt tgtttcaaca ccagttttca gctatgatgc     1200

catttcgtac tacaaaatat ttagtgacaa ggatggctac aaacatattc actatatcaa     1260

agacactgtg gaaaatgcta ttcaaattac aagtggcaag tgggaggcca taaatatatt     1320

cagagtaaca caggattcac tgttttattc tagcaatgaa tttgaagaat accctggaag     1380

aagaaacatc tacagaatta gcattggaag ctatcctcca agcaagaagt gtgttacttg     1440

ccatctaagg aaagaaaggt gccaatatta cacagcaagt ttcagcgact acgccaagta     1500

ctatgcactt gtctgctacg gcccaggcat ccccatttcc acccttcatg atggacgcac     1560

tgatcaagaa attaaaatcc tggaagaaaa caaggaattg gaaaatgctt tgaaaaatat     1620

ccagctgcct aaagaggaaa ttaagaaact tgaagtagat gaaattactt tatggtacaa     1680

gatgattctt cctcctcaat ttgacagatc aaagaagtat cccttgctaa ttcaagtgta     1740

tggtggtccc tgcagtcaga gtgtaaggtc tgtatttgct gttaattgga tatcttatct     1800

tgcaagtaag gaagggatgg tcattgcctt ggtggatggt cgaggaacag ctttccaagg     1860

tgacaaactc ctctatgcag tgtatcgaaa gctgggtgtt tatgaagttg aagaccagat     1920

tacagctgtc agaaaattca tagaaatggg tttcattgat gaaaaaagaa tagccatatg     1980

gggctggtcc tatggaggat acgtttcatc actggccctt gcatctggaa ctggtctttt     2040

caaatgtggt atagcagtgg ctccagtctc cagctgggaa tattacgcgt ctgtctacac     2100

agagagattc atgggtctcc caacaaagga tgataatctt gagcactata agaattcaac     2160

tgtgatggca agagcagaat atttcagaaa tgtagactat cttctcatcc acggaacagc     2220

agatgataat gtgcactttc aaaactcagc acagattgct aaagctctgg ttaatgcaca     2280

agtggatttc caggcaatgt ggtactctga ccagaaccac ggcttatccg gcctgtccac     2340

gaaccactta tacacccaca tgacccactt cctaaagcag tgtttctctt tgtcagacta     2400

aaaacgatgc agatgcaagc ctgtatcaga atctgaaaac cttatataaa cccctcagac     2460

agtttgctta ttttattttt tatgttgtaa aatgctagta taaacaaaca aattaatgtt     2520

gttctaaagg ctgttaaaaa aaagatgagg actcagaagt tcaagctaaa tattgtttac     2580

attttctggt actctgtgaa agaagagaaa agggagtcat gcattttgct ttggacacag     2640

tgttttatca cctgttcatt tgaagaaaaa taataaagtc agaagttcaa gtgcta         2696


<210>  23
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Asn Arg Cys Trp Ala Leu Phe Leu Ser Leu Cys Cys Tyr Leu Arg 
1               5                   10                  15      


Leu Val Ser Ala Glu Gly Asp Pro Ile Pro Glu Glu Leu Tyr Glu Met 
            20                  25                  30          


Leu Ser Asp His Ser Ile Arg Ser Phe Asp Asp Leu Gln Arg Leu Leu 
        35                  40                  45              


His Gly Asp Pro Gly Glu Glu Asp Gly Ala Glu Leu Asp Leu Asn Met 
    50                  55                  60                  


Thr Arg Ser His Ser Gly Gly Glu Leu Glu Ser Leu Ala Arg Gly Arg 
65                  70                  75                  80  


Arg Ser Leu Gly Ser Leu Thr Ile Ala Glu Pro Ala Met Ile Ala Glu 
                85                  90                  95      


Cys Lys Thr Arg Thr Glu Val Phe Glu Ile Ser Arg Arg Leu Ile Asp 
            100                 105                 110         


Arg Thr Asn Ala Asn Phe Leu Val Trp Pro Pro Cys Val Glu Val Gln 
        115                 120                 125             


Arg Cys Ser Gly Cys Cys Asn Asn Arg Asn Val Gln Cys Arg Pro Thr 
    130                 135                 140                 


Gln Val Gln Leu Arg Pro Val Gln Val Arg Lys Ile Glu Ile Val Arg 
145                 150                 155                 160 


Lys Lys Pro Ile Phe Lys Lys Ala Thr Val Thr Leu Glu Asp His Leu 
                165                 170                 175     


Ala Cys Lys Cys Glu Thr Val Ala Ala Ala Arg Pro Val Thr Arg Ser 
            180                 185                 190         


Pro Gly Gly Ser Gln Glu Gln Arg Ala Lys Thr Pro Gln Thr Arg Val 
        195                 200                 205             


Thr Ile Arg Thr Val Arg Val Arg Arg Pro Pro Lys Gly Lys His Arg 
    210                 215                 220                 


Lys Phe Lys His Thr His Asp Lys Thr Ala Leu Lys Glu Thr Leu Gly 
225                 230                 235                 240 


Ala 
    


<210>  24
<211>  3801
<212>  DNA
<213>  Homo sapiens

<400>  24
gaggaaaggc tgtctccacc cacctctcgc actctccctt ctcctttata aaggccggaa       60

cagctgaaag ggtggcaact tctcctcctg cagccgggag cggcctgcct gcctccctgc      120

gcacccgcag cctcccccgc tgcctcccta gggctcccct ccggccgcca gcgcccattt      180

ttcattccct agatagagat actttgcgcg cacacacata catacgcgcg caaaaaggaa      240

aaaaaaaaaa aaaagcccac cctccagcct cgctgcaaag agaaaaccgg agcagccgca      300

gctcgcagct cgcagctcgc agcccgcagc ccgcagagga cgcccagagc ggcgagcggg      360

cgggcagacg gaccgacgga ctcgcgccgc gtccacctgt cggccgggcc cagccgagcg      420

cgcagcgggc acgccgcgcg cgcggagcag ccgtgcccgc cgcccgggcc ccgcgccagg      480

gcgcacacgc tcccgccccc ctacccggcc cgggcgggag tttgcacctc tccctgcccg      540

ggtgctcgag ctgccgttgc aaagccaact ttggaaaaag ttttttgggg gagacttggg      600

ccttgaggtg cccagctccg cgctttccga ttttgggggc ctttccagaa aatgttgcaa      660

aaaagctaag ccggcgggca gaggaaaacg cctgtagccg gcgagtgaag acgaaccatc      720

gactgccgtg ttccttttcc tcttggaggt tggagtcccc tgggcgcccc cacacggcta      780

gacgcctcgg ctggttcgcg acgcagcccc ccggccgtgg atgctcactc gggctcggga      840

tccgcccagg tagcggcctc ggacccaggt cctgcgccca ggtcctcccc tgccccccag      900

cgacggagcc ggggccgggg gcggcggcgc ccgggggcca tgcgggtgag ccgcggctgc      960

agaggcctga gcgcctgatc gccgcggacc cgagccgagc ccacccccct ccccagcccc     1020

ccaccctggc cgcgggggcg gcgcgctcga tctacgcgtc cggggccccg cggggccggg     1080

cccggagtcg gcatgaatcg ctgctgggcg ctcttcctgt ctctctgctg ctacctgcgt     1140

ctggtcagcg ccgaggggga ccccattccc gaggagcttt atgagatgct gagtgaccac     1200

tcgatccgct cctttgatga tctccaacgc ctgctgcacg gagaccccgg agaggaagat     1260

ggggccgagt tggacctgaa catgacccgc tcccactctg gaggcgagct ggagagcttg     1320

gctcgtggaa gaaggagcct gggttccctg accattgctg agccggccat gatcgccgag     1380

tgcaagacgc gcaccgaggt gttcgagatc tcccggcgcc tcatagaccg caccaacgcc     1440

aacttcctgg tgtggccgcc ctgtgtggag gtgcagcgct gctccggctg ctgcaacaac     1500

cgcaacgtgc agtgccgccc cacccaggtg cagctgcgac ctgtccaggt gagaaagatc     1560

gagattgtgc ggaagaagcc aatctttaag aaggccacgg tgacgctgga agaccacctg     1620

gcatgcaagt gtgagacagt ggcagctgca cggcctgtga cccgaagccc ggggggttcc     1680

caggagcagc gagccaaaac gccccaaact cgggtgacca ttcggacggt gcgagtccgc     1740

cggcccccca agggcaagca ccggaaattc aagcacacgc atgacaagac ggcactgaag     1800

gagacccttg gagcctaggg gcatcggcag gagagtgtgt gggcagggtt atttaatatg     1860

gtatttgctg tattgccccc atggggtcct tggagtgata atattgtttc cctcgtccgt     1920

ctgtctcgat gcctgattcg gacggccaat ggtgcttccc ccacccctcc acgtgtccgt     1980

ccacccttcc atcagcgggt ctcctcccag cggcctccgg cgtcttgccc agcagctcaa     2040

gaagaaaaag aaggactgaa ctccatcgcc atcttcttcc cttaactcca agaacttggg     2100

ataagagtgt gagagagact gatggggtcg ctctttgggg gaaacgggct ccttcccctg     2160

cacctggcct gggccacacc tgagcgctgt ggactgtcct gaggagccct gaggacctct     2220

cagcatagcc tgcctgatcc ctgaacccct ggccagctct gaggggaggc acctccaggc     2280

aggccaggct gcctcggact ccatggctaa gaccacagac gggcacacag actggagaaa     2340

acccctccca cggtgcccaa acaccagtca cctcgtctcc ctggtgcctc tgtgcacagt     2400

ggcttctttt cgttttcgtt ttgaagacgt ggactcctct tggtgggtgt ggccagcaca     2460

ccaagtggct gggtgccctc tcaggtgggt tagagatgga gtttgctgtt gaggtggctg     2520

tagatggtga cctgggtatc ccctgcctcc tgccacccct tcctccccac actccactct     2580

gattcacctc ttcctctggt tcctttcatc tctctacctc caccctgcat tttcctcttg     2640

tcctggccct tcagtctgct ccaccaaggg gctcttgaac cccttattaa ggccccagat     2700

gatcccagtc actcctctct agggcagaag actagaggcc agggcagcaa gggacctgct     2760

catcatattc caacccagcc acgactgcca tgtaaggttg tgcagggtgt gtactgcaca     2820

aggacattgt atgcagggag cactgttcac atcatagata aagctgattt gtatatttat     2880

tatgacaatt tctggcagat gtaggtaaag aggaaaagga tccttttcct aattcacaca     2940

aagactcctt gtggactggc tgtgcccctg atgcagcctg tggcttggag tggccaaata     3000

ggagggagac tgtggtaggg gcagggaggc aacactgctg tccacatgac ctccatttcc     3060

caaagtcctc tgctccagca actgcccttc caggtgggtg tgggacacct gggagaaggt     3120

ctccaaggga gggtgcagcc ctcttgcccg cacccctccc tgcttgcaca cttccccatc     3180

tttgatcctt ctgagctcca cctctggtgg ctcctcctag gaaaccagct cgtgggctgg     3240

gaatggggga gagaagggaa aagatcccca agaccccctg gggtgggatc tgagctccca     3300

cctcccttcc cacctactgc actttccccc ttcccgcctt ccaaaacctg cttccttcag     3360

tttgtaaagt cggtgattat atttttgggg gctttccttt tattttttaa atgtaaaatt     3420

tatttatatt ccgtatttaa agttgtaaaa aaaaataacc acaaaacaaa accaaatgaa     3480

tccgccggag gtctgtctgt tggcatcgtg cgtgacaatt aacctttctg ccttggcagg     3540

atgtgccgac agcttgcggc gtgttcctct cactctggga gcctcaggcg tgatctcaca     3600

cactggcgtg cacatacaca cacacacaca tacatgctca cacatgcgtg cacatacacg     3660

caggcctgca acttggggga ggcctctgtc tggcgggaag aagagacaca caggctactc     3720

tgttggtctt ggtcctggca cagctcctga cacgtggact tgtgcgtgtc tctggcagtg     3780

acgagagatg ggtttctgca g                                               3801


<210>  25
<211>  1663
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Gly Pro Thr Ser Gly Pro Ser Leu Leu Leu Leu Leu Leu Thr His 
1               5                   10                  15      


Leu Pro Leu Ala Leu Gly Ser Pro Met Tyr Ser Ile Ile Thr Pro Asn 
            20                  25                  30          


Ile Leu Arg Leu Glu Ser Glu Glu Thr Met Val Leu Glu Ala His Asp 
        35                  40                  45              


Ala Gln Gly Asp Val Pro Val Thr Val Thr Val His Asp Phe Pro Gly 
    50                  55                  60                  


Lys Lys Leu Val Leu Ser Ser Glu Lys Thr Val Leu Thr Pro Ala Thr 
65                  70                  75                  80  


Asn His Met Gly Asn Val Thr Phe Thr Ile Pro Ala Asn Arg Glu Phe 
                85                  90                  95      


Lys Ser Glu Lys Gly Arg Asn Lys Phe Val Thr Val Gln Ala Thr Phe 
            100                 105                 110         


Gly Thr Gln Val Val Glu Lys Val Val Leu Val Ser Leu Gln Ser Gly 
        115                 120                 125             


Tyr Leu Phe Ile Gln Thr Asp Lys Thr Ile Tyr Thr Pro Gly Ser Thr 
    130                 135                 140                 


Val Leu Tyr Arg Ile Phe Thr Val Asn His Lys Leu Leu Pro Val Gly 
145                 150                 155                 160 


Arg Thr Val Met Val Asn Ile Glu Asn Pro Glu Gly Ile Pro Val Lys 
                165                 170                 175     


Gln Asp Ser Leu Ser Ser Gln Asn Gln Leu Gly Val Leu Pro Leu Ser 
            180                 185                 190         


Trp Asp Ile Pro Glu Leu Val Asn Met Gly Gln Trp Lys Ile Arg Ala 
        195                 200                 205             


Tyr Tyr Glu Asn Ser Pro Gln Gln Val Phe Ser Thr Glu Phe Glu Val 
    210                 215                 220                 


Lys Glu Tyr Val Leu Pro Ser Phe Glu Val Ile Val Glu Pro Thr Glu 
225                 230                 235                 240 


Lys Phe Tyr Tyr Ile Tyr Asn Glu Lys Gly Leu Glu Val Thr Ile Thr 
                245                 250                 255     


Ala Arg Phe Leu Tyr Gly Lys Lys Val Glu Gly Thr Ala Phe Val Ile 
            260                 265                 270         


Phe Gly Ile Gln Asp Gly Glu Gln Arg Ile Ser Leu Pro Glu Ser Leu 
        275                 280                 285             


Lys Arg Ile Pro Ile Glu Asp Gly Ser Gly Glu Val Val Leu Ser Arg 
    290                 295                 300                 


Lys Val Leu Leu Asp Gly Val Gln Asn Pro Arg Ala Glu Asp Leu Val 
305                 310                 315                 320 


Gly Lys Ser Leu Tyr Val Ser Ala Thr Val Ile Leu His Ser Gly Ser 
                325                 330                 335     


Asp Met Val Gln Ala Glu Arg Ser Gly Ile Pro Ile Val Thr Ser Pro 
            340                 345                 350         


Tyr Gln Ile His Phe Thr Lys Thr Pro Lys Tyr Phe Lys Pro Gly Met 
        355                 360                 365             


Pro Phe Asp Leu Met Val Phe Val Thr Asn Pro Asp Gly Ser Pro Ala 
    370                 375                 380                 


Tyr Arg Val Pro Val Ala Val Gln Gly Glu Asp Thr Val Gln Ser Leu 
385                 390                 395                 400 


Thr Gln Gly Asp Gly Val Ala Lys Leu Ser Ile Asn Thr His Pro Ser 
                405                 410                 415     


Gln Lys Pro Leu Ser Ile Thr Val Arg Thr Lys Lys Gln Glu Leu Ser 
            420                 425                 430         


Glu Ala Glu Gln Ala Thr Arg Thr Met Gln Ala Leu Pro Tyr Ser Thr 
        435                 440                 445             


Val Gly Asn Ser Asn Asn Tyr Leu His Leu Ser Val Leu Arg Thr Glu 
    450                 455                 460                 


Leu Arg Pro Gly Glu Thr Leu Asn Val Asn Phe Leu Leu Arg Met Asp 
465                 470                 475                 480 


Arg Ala His Glu Ala Lys Ile Arg Tyr Tyr Thr Tyr Leu Ile Met Asn 
                485                 490                 495     


Lys Gly Arg Leu Leu Lys Ala Gly Arg Gln Val Arg Glu Pro Gly Gln 
            500                 505                 510         


Asp Leu Val Val Leu Pro Leu Ser Ile Thr Thr Asp Phe Ile Pro Ser 
        515                 520                 525             


Phe Arg Leu Val Ala Tyr Tyr Thr Leu Ile Gly Ala Ser Gly Gln Arg 
    530                 535                 540                 


Glu Val Val Ala Asp Ser Val Trp Val Asp Val Lys Asp Ser Cys Val 
545                 550                 555                 560 


Gly Ser Leu Val Val Lys Ser Gly Gln Ser Glu Asp Arg Gln Pro Val 
                565                 570                 575     


Pro Gly Gln Gln Met Thr Leu Lys Ile Glu Gly Asp His Gly Ala Arg 
            580                 585                 590         


Val Val Leu Val Ala Val Asp Lys Gly Val Phe Val Leu Asn Lys Lys 
        595                 600                 605             


Asn Lys Leu Thr Gln Ser Lys Ile Trp Asp Val Val Glu Lys Ala Asp 
    610                 615                 620                 


Ile Gly Cys Thr Pro Gly Ser Gly Lys Asp Tyr Ala Gly Val Phe Ser 
625                 630                 635                 640 


Asp Ala Gly Leu Thr Phe Thr Ser Ser Ser Gly Gln Gln Thr Ala Gln 
                645                 650                 655     


Arg Ala Glu Leu Gln Cys Pro Gln Pro Ala Ala Arg Arg Arg Arg Ser 
            660                 665                 670         


Val Gln Leu Thr Glu Lys Arg Met Asp Lys Val Gly Lys Tyr Pro Lys 
        675                 680                 685             


Glu Leu Arg Lys Cys Cys Glu Asp Gly Met Arg Glu Asn Pro Met Arg 
    690                 695                 700                 


Phe Ser Cys Gln Arg Arg Thr Arg Phe Ile Ser Leu Gly Glu Ala Cys 
705                 710                 715                 720 


Lys Lys Val Phe Leu Asp Cys Cys Asn Tyr Ile Thr Glu Leu Arg Arg 
                725                 730                 735     


Gln His Ala Arg Ala Ser His Leu Gly Leu Ala Arg Ser Asn Leu Asp 
            740                 745                 750         


Glu Asp Ile Ile Ala Glu Glu Asn Ile Val Ser Arg Ser Glu Phe Pro 
        755                 760                 765             


Glu Ser Trp Leu Trp Asn Val Glu Asp Leu Lys Glu Pro Pro Lys Asn 
    770                 775                 780                 


Gly Ile Ser Thr Lys Leu Met Asn Ile Phe Leu Lys Asp Ser Ile Thr 
785                 790                 795                 800 


Thr Trp Glu Ile Leu Ala Val Ser Met Ser Asp Lys Lys Gly Ile Cys 
                805                 810                 815     


Val Ala Asp Pro Phe Glu Val Thr Val Met Gln Asp Phe Phe Ile Asp 
            820                 825                 830         


Leu Arg Leu Pro Tyr Ser Val Val Arg Asn Glu Gln Val Glu Ile Arg 
        835                 840                 845             


Ala Val Leu Tyr Asn Tyr Arg Gln Asn Gln Glu Leu Lys Val Arg Val 
    850                 855                 860                 


Glu Leu Leu His Asn Pro Ala Phe Cys Ser Leu Ala Thr Thr Lys Arg 
865                 870                 875                 880 


Arg His Gln Gln Thr Val Thr Ile Pro Pro Lys Ser Ser Leu Ser Val 
                885                 890                 895     


Pro Tyr Val Ile Val Pro Leu Lys Thr Gly Leu Gln Glu Val Glu Val 
            900                 905                 910         


Lys Ala Ala Val Tyr His His Phe Ile Ser Asp Gly Val Arg Lys Ser 
        915                 920                 925             


Leu Lys Val Val Pro Glu Gly Ile Arg Met Asn Lys Thr Val Ala Val 
    930                 935                 940                 


Arg Thr Leu Asp Pro Glu Arg Leu Gly Arg Glu Gly Val Gln Lys Glu 
945                 950                 955                 960 


Asp Ile Pro Pro Ala Asp Leu Ser Asp Gln Val Pro Asp Thr Glu Ser 
                965                 970                 975     


Glu Thr Arg Ile Leu Leu Gln Gly Thr Pro Val Ala Gln Met Thr Glu 
            980                 985                 990         


Asp Ala Val Asp Ala Glu Arg Leu  Lys His Leu Ile Val  Thr Pro Ser 
        995                 1000                 1005             


Gly Cys  Gly Glu Gln Asn Met  Ile Gly Met Thr Pro  Thr Val Ile 
    1010                 1015                 1020             


Ala Val  His Tyr Leu Asp Glu  Thr Glu Gln Trp Glu  Lys Phe Gly 
    1025                 1030                 1035             


Leu Glu  Lys Arg Gln Gly Ala  Leu Glu Leu Ile Lys  Lys Gly Tyr 
    1040                 1045                 1050             


Thr Gln  Gln Leu Ala Phe Arg  Gln Pro Ser Ser Ala  Phe Ala Ala 
    1055                 1060                 1065             


Phe Val  Lys Arg Ala Pro Ser  Thr Trp Leu Thr Ala  Tyr Val Val 
    1070                 1075                 1080             


Lys Val  Phe Ser Leu Ala Val  Asn Leu Ile Ala Ile  Asp Ser Gln 
    1085                 1090                 1095             


Val Leu  Cys Gly Ala Val Lys  Trp Leu Ile Leu Glu  Lys Gln Lys 
    1100                 1105                 1110             


Pro Asp  Gly Val Phe Gln Glu  Asp Ala Pro Val Ile  His Gln Glu 
    1115                 1120                 1125             


Met Ile  Gly Gly Leu Arg Asn  Asn Asn Glu Lys Asp  Met Ala Leu 
    1130                 1135                 1140             


Thr Ala  Phe Val Leu Ile Ser  Leu Gln Glu Ala Lys  Asp Ile Cys 
    1145                 1150                 1155             


Glu Glu  Gln Val Asn Ser Leu  Pro Gly Ser Ile Thr  Lys Ala Gly 
    1160                 1165                 1170             


Asp Phe  Leu Glu Ala Asn Tyr  Met Asn Leu Gln Arg  Ser Tyr Thr 
    1175                 1180                 1185             


Val Ala  Ile Ala Gly Tyr Ala  Leu Ala Gln Met Gly  Arg Leu Lys 
    1190                 1195                 1200             


Gly Pro  Leu Leu Asn Lys Phe  Leu Thr Thr Ala Lys  Asp Lys Asn 
    1205                 1210                 1215             


Arg Trp  Glu Asp Pro Gly Lys  Gln Leu Tyr Asn Val  Glu Ala Thr 
    1220                 1225                 1230             


Ser Tyr  Ala Leu Leu Ala Leu  Leu Gln Leu Lys Asp  Phe Asp Phe 
    1235                 1240                 1245             


Val Pro  Pro Val Val Arg Trp  Leu Asn Glu Gln Arg  Tyr Tyr Gly 
    1250                 1255                 1260             


Gly Gly  Tyr Gly Ser Thr Gln  Ala Thr Phe Met Val  Phe Gln Ala 
    1265                 1270                 1275             


Leu Ala  Gln Tyr Gln Lys Asp  Ala Pro Asp His Gln  Glu Leu Asn 
    1280                 1285                 1290             


Leu Asp  Val Ser Leu Gln Leu  Pro Ser Arg Ser Ser  Lys Ile Thr 
    1295                 1300                 1305             


His Arg  Ile His Trp Glu Ser  Ala Ser Leu Leu Arg  Ser Glu Glu 
    1310                 1315                 1320             


Thr Lys  Glu Asn Glu Gly Phe  Thr Val Thr Ala Glu  Gly Lys Gly 
    1325                 1330                 1335             


Gln Gly  Thr Leu Ser Val Val  Thr Met Tyr His Ala  Lys Ala Lys 
    1340                 1345                 1350             


Asp Gln  Leu Thr Cys Asn Lys  Phe Asp Leu Lys Val  Thr Ile Lys 
    1355                 1360                 1365             


Pro Ala  Pro Glu Thr Glu Lys  Arg Pro Gln Asp Ala  Lys Asn Thr 
    1370                 1375                 1380             


Met Ile  Leu Glu Ile Cys Thr  Arg Tyr Arg Gly Asp  Gln Asp Ala 
    1385                 1390                 1395             


Thr Met  Ser Ile Leu Asp Ile  Ser Met Met Thr Gly  Phe Ala Pro 
    1400                 1405                 1410             


Asp Thr  Asp Asp Leu Lys Gln  Leu Ala Asn Gly Val  Asp Arg Tyr 
    1415                 1420                 1425             


Ile Ser  Lys Tyr Glu Leu Asp  Lys Ala Phe Ser Asp  Arg Asn Thr 
    1430                 1435                 1440             


Leu Ile  Ile Tyr Leu Asp Lys  Val Ser His Ser Glu  Asp Asp Cys 
    1445                 1450                 1455             


Leu Ala  Phe Lys Val His Gln  Tyr Phe Asn Val Glu  Leu Ile Gln 
    1460                 1465                 1470             


Pro Gly  Ala Val Lys Val Tyr  Ala Tyr Tyr Asn Leu  Glu Glu Ser 
    1475                 1480                 1485             


Cys Thr  Arg Phe Tyr His Pro  Glu Lys Glu Asp Gly  Lys Leu Asn 
    1490                 1495                 1500             


Lys Leu  Cys Arg Asp Glu Leu  Cys Arg Cys Ala Glu  Glu Asn Cys 
    1505                 1510                 1515             


Phe Ile  Gln Lys Ser Asp Asp  Lys Val Thr Leu Glu  Glu Arg Leu 
    1520                 1525                 1530             


Asp Lys  Ala Cys Glu Pro Gly  Val Asp Tyr Val Tyr  Lys Thr Arg 
    1535                 1540                 1545             


Leu Val  Lys Val Gln Leu Ser  Asn Asp Phe Asp Glu  Tyr Ile Met 
    1550                 1555                 1560             


Ala Ile  Glu Gln Thr Ile Lys  Ser Gly Ser Asp Glu  Val Gln Val 
    1565                 1570                 1575             


Gly Gln  Gln Arg Thr Phe Ile  Ser Pro Ile Lys Cys  Arg Glu Ala 
    1580                 1585                 1590             


Leu Lys  Leu Glu Glu Lys Lys  His Tyr Leu Met Trp  Gly Leu Ser 
    1595                 1600                 1605             


Ser Asp  Phe Trp Gly Glu Lys  Pro Asn Leu Ser Tyr  Ile Ile Gly 
    1610                 1615                 1620             


Lys Asp  Thr Trp Val Glu His  Trp Pro Glu Glu Asp  Glu Cys Gln 
    1625                 1630                 1635             


Asp Glu  Glu Asn Gln Lys Gln  Cys Gln Asp Leu Gly  Ala Phe Thr 
    1640                 1645                 1650             


Glu Ser  Met Val Val Phe Gly  Cys Pro Asn 
    1655                 1660             


<210>  26
<211>  5148
<212>  DNA
<213>  Homo sapiens

<400>  26
agataaaaag ccagctccag caggcgctgc tcactcctcc ccatcctctc cctctgtccc       60

tctgtccctc tgaccctgca ctgtcccagc accatgggac ccacctcagg tcccagcctg      120

ctgctcctgc tactaaccca cctccccctg gctctgggga gtcccatgta ctctatcatc      180

acccccaaca tcttgcggct ggagagcgag gagaccatgg tgctggaggc ccacgacgcg      240

caaggggatg ttccagtcac tgttactgtc cacgacttcc caggcaaaaa actagtgctg      300

tccagtgaga agactgtgct gacccctgcc accaaccaca tgggcaacgt caccttcacg      360

atcccagcca acagggagtt caagtcagaa aaggggcgca acaagttcgt gaccgtgcag      420

gccaccttcg ggacccaagt ggtggagaag gtggtgctgg tcagcctgca gagcgggtac      480

ctcttcatcc agacagacaa gaccatctac acccctggct ccacagttct ctatcggatc      540

ttcaccgtca accacaagct gctacccgtg ggccggacgg tcatggtcaa cattgagaac      600

ccggaaggca tcccggtcaa gcaggactcc ttgtcttctc agaaccagct tggcgtcttg      660

cccttgtctt gggacattcc ggaactcgtc aacatgggcc agtggaagat ccgagcctac      720

tatgaaaact caccacagca ggtcttctcc actgagtttg aggtgaagga gtacgtgctg      780

cccagtttcg aggtcatagt ggagcctaca gagaaattct actacatcta taacgagaag      840

ggcctggagg tcaccatcac cgccaggttc ctctacggga agaaagtgga gggaactgcc      900

tttgtcatct tcgggatcca ggatggcgaa cagaggattt ccctgcctga atccctcaag      960

cgcattccga ttgaggatgg ctcgggggag gttgtgctga gccggaaggt actgctggac     1020

ggggtgcaga acccccgagc agaagacctg gtggggaagt ctttgtacgt gtctgccacc     1080

gtcatcttgc actcaggcag tgacatggtg caggcagagc gcagcgggat ccccatcgtg     1140

acctctccct accagatcca cttcaccaag acacccaagt acttcaaacc aggaatgccc     1200

tttgacctca tggtgttcgt gacgaaccct gatggctctc cagcctaccg agtccccgtg     1260

gcagtccagg gcgaggacac tgtgcagtct ctaacccagg gagatggcgt ggccaaactc     1320

agcatcaaca cacaccccag ccagaagccc ttgagcatca cggtgcgcac gaagaagcag     1380

gagctctcgg aggcagagca ggctaccagg accatgcagg ctctgcccta cagcaccgtg     1440

ggcaactcca acaattacct gcatctctca gtgctacgta cagagctcag acccggggag     1500

accctcaacg tcaacttcct cctgcgaatg gaccgcgccc acgaggccaa gatccgctac     1560

tacacctacc tgatcatgaa caagggcagg ctgttgaagg cgggacgcca ggtgcgagag     1620

cccggccagg acctggtggt gctgcccctg tccatcacca ccgacttcat cccttccttc     1680

cgcctggtgg cgtactacac gctgatcggt gccagcggcc agagggaggt ggtggccgac     1740

tccgtgtggg tggacgtcaa ggactcctgc gtgggctcgc tggtggtaaa aagcggccag     1800

tcagaagacc ggcagcctgt acctgggcag cagatgaccc tgaagataga gggtgaccac     1860

ggggcccggg tggtactggt ggccgtggac aagggcgtgt tcgtgctgaa taagaagaac     1920

aaactgacgc agagtaagat ctgggacgtg gtggagaagg cagacatcgg ctgcaccccg     1980

ggcagtggga aggattacgc cggtgtcttc tccgacgcag ggctgacctt cacgagcagc     2040

agtggccagc agaccgccca gagggcagaa cttcagtgcc cgcagccagc cgcccgccga     2100

cgccgttccg tgcagctcac ggagaagcga atggacaaag tcggcaagta ccccaaggag     2160

ctgcgcaagt gctgcgagga cggcatgcgg gagaacccca tgaggttctc gtgccagcgc     2220

cggacccgtt tcatctccct gggcgaggcg tgcaagaagg tcttcctgga ctgctgcaac     2280

tacatcacag agctgcggcg gcagcacgcg cgggccagcc acctgggcct ggccaggagt     2340

aacctggatg aggacatcat tgcagaagag aacatcgttt cccgaagtga gttcccagag     2400

agctggctgt ggaacgttga ggacttgaaa gagccaccga aaaatggaat ctctacgaag     2460

ctcatgaata tatttttgaa agactccatc accacgtggg agattctggc tgtgagcatg     2520

tcggacaaga aagggatctg tgtggcagac cccttcgagg tcacagtaat gcaggacttc     2580

ttcatcgacc tgcggctacc ctactctgtt gttcgaaacg agcaggtgga aatccgagcc     2640

gttctctaca attaccggca gaaccaagag ctcaaggtga gggtggaact actccacaat     2700

ccagccttct gcagcctggc caccaccaag aggcgtcacc agcagaccgt aaccatcccc     2760

cccaagtcct cgttgtccgt tccatatgtc atcgtgccgc taaagaccgg cctgcaggaa     2820

gtggaagtca aggctgctgt ctaccatcat ttcatcagtg acggtgtcag gaagtccctg     2880

aaggtcgtgc cggaaggaat cagaatgaac aaaactgtgg ctgttcgcac cctggatcca     2940

gaacgcctgg gccgtgaagg agtgcagaaa gaggacatcc cacctgcaga cctcagtgac     3000

caagtcccgg acaccgagtc tgagaccaga attctcctgc aagggacccc agtggcccag     3060

atgacagagg atgccgtcga cgcggaacgg ctgaagcacc tcattgtgac cccctcgggc     3120

tgcggggaac agaacatgat cggcatgacg cccacggtca tcgctgtgca ttacctggat     3180

gaaacggagc agtgggagaa gttcggccta gagaagcggc agggggcctt ggagctcatc     3240

aagaaggggt acacccagca gctggccttc agacaaccca gctctgcctt tgcggccttc     3300

gtgaaacggg cacccagcac ctggctgacc gcctacgtgg tcaaggtctt ctctctggct     3360

gtcaacctca tcgccatcga ctcccaagtc ctctgcgggg ctgttaaatg gctgatcctg     3420

gagaagcaga agcccgacgg ggtcttccag gaggatgcgc ccgtgataca ccaagaaatg     3480

attggtggat tacggaacaa caacgagaaa gacatggccc tcacggcctt tgttctcatc     3540

tcgctgcagg aggctaaaga tatttgcgag gagcaggtca acagcctgcc aggcagcatc     3600

actaaagcag gagacttcct tgaagccaac tacatgaacc tacagagatc ctacactgtg     3660

gccattgctg gctatgctct ggcccagatg ggcaggctga aggggcctct tcttaacaaa     3720

tttctgacca cagccaaaga taagaaccgc tgggaggacc ctggtaagca gctctacaac     3780

gtggaggcca catcctatgc cctcttggcc ctactgcagc taaaagactt tgactttgtg     3840

cctcccgtcg tgcgttggct caatgaacag agatactacg gtggtggcta tggctctacc     3900

caggccacct tcatggtgtt ccaagccttg gctcaatacc aaaaggacgc ccctgaccac     3960

caggaactga accttgatgt gtccctccaa ctgcccagcc gcagctccaa gatcacccac     4020

cgtatccact gggaatctgc cagcctcctg cgatcagaag agaccaagga aaatgagggt     4080

ttcacagtca cagctgaagg aaaaggccaa ggcaccttgt cggtggtgac aatgtaccat     4140

gctaaggcca aagatcaact cacctgtaat aaattcgacc tcaaggtcac cataaaacca     4200

gcaccggaaa cagaaaagag gcctcaggat gccaagaaca ctatgatcct tgagatctgt     4260

accaggtacc ggggagacca ggatgccact atgtctatat tggacatatc catgatgact     4320

ggctttgctc cagacacaga tgacctgaag cagctggcca atggtgttga cagatacatc     4380

tccaagtatg agctggacaa agccttctcc gataggaaca ccctcatcat ctacctggac     4440

aaggtctcac actctgagga tgactgtcta gctttcaaag ttcaccaata ctttaatgta     4500

gagcttatcc agcctggagc agtcaaggtc tacgcctatt acaacctgga ggaaagctgt     4560

acccggttct accatccgga aaaggaggat ggaaagctga acaagctctg ccgtgatgaa     4620

ctgtgccgct gtgctgagga gaattgcttc atacaaaagt cggatgacaa ggtcaccctg     4680

gaagaacggc tggacaaggc ctgtgagcca ggagtggact atgtgtacaa gacccgactg     4740

gtcaaggttc agctgtccaa tgactttgac gagtacatca tggccattga gcagaccatc     4800

aagtcaggct cggatgaggt gcaggttgga cagcagcgca cgttcatcag ccccatcaag     4860

tgcagagaag ccctgaagct ggaggagaag aaacactacc tcatgtgggg tctctcctcc     4920

gatttctggg gagagaagcc caacctcagc tacatcatcg ggaaggacac ttgggtggag     4980

cactggcccg aggaggacga atgccaagac gaagagaacc agaaacaatg ccaggacctc     5040

ggcgccttca ccgagagcat ggttgtcttt gggtgcccca actgaccaca cccccattcc     5100

cccactccag ataaagcttc agttatatct caaaaaaaaa aaaaaaaa                  5148


<210>  27
<211>  1091
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Ala Gly Cys Leu Leu Ala Leu Thr Leu Thr Leu Phe Gln Ser 
1               5                   10                  15      


Leu Leu Ile Gly Pro Ser Ser Glu Glu Pro Phe Pro Ser Ala Val Thr 
            20                  25                  30          


Ile Lys Ser Trp Val Asp Lys Met Gln Glu Asp Leu Val Thr Leu Ala 
        35                  40                  45              


Lys Thr Ala Ser Gly Val Asn Gln Leu Val Asp Ile Tyr Glu Lys Tyr 
    50                  55                  60                  


Gln Asp Leu Tyr Thr Val Glu Pro Asn Asn Ala Arg Gln Leu Val Glu 
65                  70                  75                  80  


Ile Ala Ala Arg Asp Ile Glu Lys Leu Leu Ser Asn Arg Ser Lys Ala 
                85                  90                  95      


Leu Val Arg Leu Ala Leu Glu Ala Glu Lys Val Gln Ala Ala His Gln 
            100                 105                 110         


Trp Arg Glu Asp Phe Ala Ser Asn Glu Val Val Tyr Tyr Asn Ala Lys 
        115                 120                 125             


Asp Asp Leu Asp Pro Glu Lys Asn Asp Ser Glu Pro Gly Ser Gln Arg 
    130                 135                 140                 


Ile Lys Pro Val Phe Ile Glu Asp Ala Asn Phe Gly Arg Gln Ile Ser 
145                 150                 155                 160 


Tyr Gln His Ala Ala Val His Ile Pro Thr Asp Ile Tyr Glu Gly Ser 
                165                 170                 175     


Thr Ile Val Leu Asn Glu Leu Asn Trp Thr Ser Ala Leu Asp Glu Val 
            180                 185                 190         


Phe Lys Lys Asn Arg Glu Glu Asp Pro Ser Leu Leu Trp Gln Val Phe 
        195                 200                 205             


Gly Ser Ala Thr Gly Leu Ala Arg Tyr Tyr Pro Ala Ser Pro Trp Val 
    210                 215                 220                 


Asp Asn Ser Arg Thr Pro Asn Lys Ile Asp Leu Tyr Asp Val Arg Arg 
225                 230                 235                 240 


Arg Pro Trp Tyr Ile Gln Gly Ala Ala Ser Pro Lys Asp Met Leu Ile 
                245                 250                 255     


Leu Val Asp Val Ser Gly Ser Val Ser Gly Leu Thr Leu Lys Leu Ile 
            260                 265                 270         


Arg Thr Ser Val Ser Glu Met Leu Glu Thr Leu Ser Asp Asp Asp Phe 
        275                 280                 285             


Val Asn Val Ala Ser Phe Asn Ser Asn Ala Gln Asp Val Ser Cys Phe 
    290                 295                 300                 


Gln His Leu Val Gln Ala Asn Val Arg Asn Lys Lys Val Leu Lys Asp 
305                 310                 315                 320 


Ala Val Asn Asn Ile Thr Ala Lys Gly Ile Thr Asp Tyr Lys Lys Gly 
                325                 330                 335     


Phe Ser Phe Ala Phe Glu Gln Leu Leu Asn Tyr Asn Val Ser Arg Ala 
            340                 345                 350         


Asn Cys Asn Lys Ile Ile Met Leu Phe Thr Asp Gly Gly Glu Glu Arg 
        355                 360                 365             


Ala Gln Glu Ile Phe Asn Lys Tyr Asn Lys Asp Lys Lys Val Arg Val 
    370                 375                 380                 


Phe Thr Phe Ser Val Gly Gln His Asn Tyr Asp Arg Gly Pro Ile Gln 
385                 390                 395                 400 


Trp Met Ala Cys Glu Asn Lys Gly Tyr Tyr Tyr Glu Ile Pro Ser Ile 
                405                 410                 415     


Gly Ala Ile Arg Ile Asn Thr Gln Glu Tyr Leu Asp Val Leu Gly Arg 
            420                 425                 430         


Pro Met Val Leu Ala Gly Asp Lys Ala Lys Gln Val Gln Trp Thr Asn 
        435                 440                 445             


Val Tyr Leu Asp Ala Leu Glu Leu Gly Leu Val Ile Thr Gly Thr Leu 
    450                 455                 460                 


Pro Val Phe Asn Ile Thr Gly Gln Phe Glu Asn Lys Thr Asn Leu Lys 
465                 470                 475                 480 


Asn Gln Leu Ile Leu Gly Val Met Gly Val Asp Val Ser Leu Glu Asp 
                485                 490                 495     


Ile Lys Arg Leu Thr Pro Arg Phe Thr Leu Cys Pro Asn Gly Tyr Tyr 
            500                 505                 510         


Phe Ala Ile Asp Pro Asn Gly Tyr Val Leu Leu His Pro Asn Leu Gln 
        515                 520                 525             


Pro Lys Asn Pro Lys Ser Gln Glu Pro Val Thr Leu Asp Phe Leu Asp 
    530                 535                 540                 


Ala Glu Leu Glu Asn Asp Ile Lys Val Glu Ile Arg Asn Lys Met Ile 
545                 550                 555                 560 


Asp Gly Glu Ser Gly Glu Lys Thr Phe Arg Thr Leu Val Lys Ser Gln 
                565                 570                 575     


Asp Glu Arg Tyr Ile Asp Lys Gly Asn Arg Thr Tyr Thr Trp Thr Pro 
            580                 585                 590         


Val Asn Gly Thr Asp Tyr Ser Leu Ala Leu Val Leu Pro Thr Tyr Ser 
        595                 600                 605             


Phe Tyr Tyr Ile Lys Ala Lys Leu Glu Glu Thr Ile Thr Gln Ala Arg 
    610                 615                 620                 


Ser Lys Lys Gly Lys Met Lys Asp Ser Glu Thr Leu Lys Pro Asp Asn 
625                 630                 635                 640 


Phe Glu Glu Ser Gly Tyr Thr Phe Ile Ala Pro Arg Asp Tyr Cys Asn 
                645                 650                 655     


Asp Leu Lys Ile Ser Asp Asn Asn Thr Glu Phe Leu Leu Asn Phe Asn 
            660                 665                 670         


Glu Phe Ile Asp Arg Lys Thr Pro Asn Asn Pro Ser Cys Asn Ala Asp 
        675                 680                 685             


Leu Ile Asn Arg Val Leu Leu Asp Ala Gly Phe Thr Asn Glu Leu Val 
    690                 695                 700                 


Gln Asn Tyr Trp Ser Lys Gln Lys Asn Ile Lys Gly Val Lys Ala Arg 
705                 710                 715                 720 


Phe Val Val Thr Asp Gly Gly Ile Thr Arg Val Tyr Pro Lys Glu Ala 
                725                 730                 735     


Gly Glu Asn Trp Gln Glu Asn Pro Glu Thr Tyr Glu Asp Ser Phe Tyr 
            740                 745                 750         


Lys Arg Ser Leu Asp Asn Asp Asn Tyr Val Phe Thr Ala Pro Tyr Phe 
        755                 760                 765             


Asn Lys Ser Gly Pro Gly Ala Tyr Glu Ser Gly Ile Met Val Ser Lys 
    770                 775                 780                 


Ala Val Glu Ile Tyr Ile Gln Gly Lys Leu Leu Lys Pro Ala Val Val 
785                 790                 795                 800 


Gly Ile Lys Ile Asp Val Asn Ser Trp Ile Glu Asn Phe Thr Lys Thr 
                805                 810                 815     


Ser Ile Arg Asp Pro Cys Ala Gly Pro Val Cys Asp Cys Lys Arg Asn 
            820                 825                 830         


Ser Asp Val Met Asp Cys Val Ile Leu Asp Asp Gly Gly Phe Leu Leu 
        835                 840                 845             


Met Ala Asn His Asp Asp Tyr Thr Asn Gln Ile Gly Arg Phe Phe Gly 
    850                 855                 860                 


Glu Ile Asp Pro Ser Leu Met Arg His Leu Val Asn Ile Ser Val Tyr 
865                 870                 875                 880 


Ala Phe Asn Lys Ser Tyr Asp Tyr Gln Ser Val Cys Glu Pro Gly Ala 
                885                 890                 895     


Ala Pro Lys Gln Gly Ala Gly His Arg Ser Ala Tyr Val Pro Ser Val 
            900                 905                 910         


Ala Asp Ile Leu Gln Ile Gly Trp Trp Ala Thr Ala Ala Ala Trp Ser 
        915                 920                 925             


Ile Leu Gln Gln Phe Leu Leu Ser Leu Thr Phe Pro Arg Leu Leu Glu 
    930                 935                 940                 


Ala Val Glu Met Glu Asp Asp Asp Phe Thr Ala Ser Leu Ser Lys Gln 
945                 950                 955                 960 


Ser Cys Ile Thr Glu Gln Thr Gln Tyr Phe Phe Asp Asn Asp Ser Lys 
                965                 970                 975     


Ser Phe Ser Gly Val Leu Asp Cys Gly Asn Cys Ser Arg Ile Phe His 
            980                 985                 990         


Gly Glu Lys Leu Met Asn Thr Asn  Leu Ile Phe Ile Met  Val Glu Ser 
        995                 1000                 1005             


Lys Gly  Thr Cys Pro Cys Asp  Thr Arg Leu Leu Ile  Gln Ala Glu 
    1010                 1015                 1020             


Gln Thr  Ser Asp Gly Pro Asn  Pro Cys Asp Met Val  Lys Gln Pro 
    1025                 1030                 1035             


Arg Tyr  Arg Lys Gly Pro Asp  Val Cys Phe Asp Asn  Asn Val Leu 
    1040                 1045                 1050             


Glu Asp  Tyr Thr Asp Cys Gly  Gly Val Ser Gly Leu  Asn Pro Ser 
    1055                 1060                 1065             


Leu Trp  Tyr Ile Ile Gly Ile  Gln Phe Leu Leu Leu  Trp Leu Val 
    1070                 1075                 1080             


Ser Gly  Ser Thr His Arg Leu  Leu 
    1085                 1090     


<210>  28
<211>  7542
<212>  DNA
<213>  Homo sapiens

<400>  28
agcgagagcg cgcgagcgcc ggcgggctcg ccgaggtctg tttccaaagt cgcccttgat       60

ggcggcggag gcaaggcggc cgcggcgcgg agcagccgac gcacgctagt gggtccgccc      120

gccaccgccc cttcctcggc gtccgctccc gcccttgccg tcccccgcgc ggctccgcgc      180

ctcgggcccc gggcgcagcc agccctccag acgcccgcgg tcccggcggc gtgtgctgct      240

cttcctccgc ccgcggtttc cagcgccgct ccttcccccg cttgggcagg gagggggcat      300

tgatcttcga tcgcgaagat ggctgctggc tgcctgctgg ccttgactct gacacttttc      360

caatctttgc tcatcggccc ctcgtcggag gagccgttcc cttcggccgt cactatcaaa      420

tcatgggtgg ataagatgca agaagacctt gtcacactgg caaaaacagc aagtggagtc      480

aatcagcttg ttgatattta tgagaaatat caagatttgt atactgtgga accaaataat      540

gcacgccagc tggtagaaat tgcagccagg gatattgaga aacttctgag caacagatct      600

aaagccctgg tgcgcctggc attggaagcg gagaaagttc aagcagctca ccagtggaga      660

gaagattttg caagcaatga agttgtctac tacaatgcaa aggatgatct cgatcctgag      720

aaaaatgaca gtgagccagg cagccagagg ataaaacctg ttttcattga agatgctaat      780

tttggacgac aaatatctta tcagcacgca gcagtccata ttcctactga catctatgag      840

ggctcaacaa ttgtgttaaa tgaactcaac tggacaagtg ccttagatga agttttcaaa      900

aagaatcgcg aggaagaccc ttcattattg tggcaggttt ttggcagtgc cactggccta      960

gctcgatatt atccagcttc accatgggtt gataatagta gaactccaaa taagattgac     1020

ctttatgatg tacgcagaag accatggtac atccaaggag ctgcatctcc taaagacatg     1080

cttattctgg tggatgtgag tggaagtgtt agtggattga cacttaaact gatccgaaca     1140

tctgtctccg aaatgttaga aaccctctca gatgatgatt tcgtgaatgt agcttcattt     1200

aacagcaatg ctcaggatgt aagctgtttt cagcaccttg tccaagcaaa tgtaagaaat     1260

aaaaaagtgt tgaaagacgc ggtgaataat atcacagcca aaggaattac agattataag     1320

aagggcttta gttttgcttt tgaacagctg cttaattata atgtttccag agcaaactgc     1380

aataagatta ttatgctatt cacggatgga ggagaagaga gagcccagga gatatttaac     1440

aaatacaata aagataaaaa agtacgtgta ttcacgtttt cagttggtca acacaattat     1500

gacagaggac ctattcagtg gatggcctgt gaaaacaaag gttattatta tgaaattcct     1560

tccattggtg caataagaat caatactcag gaatatttgg atgttttggg aagaccaatg     1620

gttttagcag gagacaaagc taagcaagtc caatggacaa atgtgtacct ggatgcattg     1680

gaactgggac ttgtcattac tggaactctt ccggtcttca acataaccgg ccaatttgaa     1740

aataagacaa acttaaagaa ccagctgatt cttggtgtga tgggagtaga tgtgtctttg     1800

gaagatatta aaagactgac accacgtttt acactgtgcc ccaatgggta ttactttgca     1860

atcgatccta atggttatgt tttattacat ccaaatcttc agccaaagaa ccccaaatct     1920

caggagccag taacattgga tttccttgat gcagagttag agaatgatat taaagtggag     1980

attcgaaata agatgattga tggggaaagt ggagaaaaaa cattcagaac tctggttaaa     2040

tctcaagatg agagatatat tgacaaagga aacaggacat acacatggac acctgtcaat     2100

ggcacagatt acagtttggc cttggtatta ccaacctaca gtttttacta tataaaagcc     2160

aaactagaag agacaataac tcaggccaga tcaaaaaagg gcaaaatgaa ggattcggaa     2220

accctgaagc cagataattt tgaagaatct ggctatacat tcatagcacc aagagattac     2280

tgcaatgacc tgaaaatatc ggataataac actgaatttc ttttaaattt caacgagttt     2340

attgatagaa aaactccaaa caacccatca tgtaacgcgg atttgattaa tagagtcttg     2400

cttgatgcag gctttacaaa tgaacttgtc caaaattact ggagtaagca gaaaaatatc     2460

aagggagtga aagcacgatt tgttgtgact gatggtggga ttaccagagt ttatcccaaa     2520

gaggctggag aaaattggca agaaaaccca gagacatatg aggacagctt ctataaaagg     2580

agcctagata atgataacta tgttttcact gctccctact ttaacaaaag tggacctggt     2640

gcctatgaat cgggcattat ggtaagcaaa gctgtagaaa tatatattca agggaaactt     2700

cttaaacctg cagttgttgg aattaaaatt gatgtaaatt cctggataga gaatttcacc     2760

aaaacctcaa tcagagatcc gtgtgctggt ccagtttgtg actgcaaaag aaacagtgac     2820

gtaatggatt gtgtgattct ggatgatggt gggtttcttc tgatggcaaa tcatgatgat     2880

tatactaatc agattggaag attttttgga gagattgatc ccagcttgat gagacacctg     2940

gttaatatat cagtttatgc ttttaacaaa tcttatgatt atcagtcagt atgtgagccc     3000

ggtgctgcac caaaacaagg agcaggacat cgctcagcat atgtgccatc agtagcagac     3060

atattacaaa ttggctggtg ggccactgct gctgcctggt ctattctaca gcagtttctc     3120

ttgagtttga cctttccacg actccttgag gcagttgaga tggaggatga tgacttcacg     3180

gcctccctgt ccaagcagag ctgcattact gaacaaaccc agtatttctt cgataacgac     3240

agtaaatcat tcagtggtgt attagactgt ggaaactgtt ccagaatctt tcatggagaa     3300

aagcttatga acaccaactt aatattcata atggttgaga gcaaagggac atgtccatgt     3360

gacacacgac tgctcataca agcggagcag acttctgacg gtccaaatcc ttgtgacatg     3420

gttaagcaac ccagataccg aaaagggcct gatgtctgct ttgataacaa tgtcttggag     3480

gattatactg actgtggtgg tgtttctgga ttaaatccct ccctgtggta tatcattgga     3540

atccagtttc tactactttg gctggtatct ggcagcacac accgcctgtt atgaccttct     3600

aaaaaccaaa tctgcatagt taaactccag accctgccaa aacatgagcc ctgccctcaa     3660

ttacagtaac gtagggtcag ctataaaatc agacaaacat tagctgggcc tgttccatgg     3720

cataacacta aggcgcagac tcctaaggca cccactggct gcatgtcagg gtgtcagatc     3780

cttaaacgtg tgtgaatgct gcatcatcta tgtgtaacat caaagcaaaa tcctatacgt     3840

gtcctctatt ggaaaatttg ggagtttgtt gttgcattgt tggtgattac atgtgaaagg     3900

gttccccata caattgttaa tgaaccataa gaaatgtctt gatattgacc tggaattttg     3960

acttgctgca attttactaa gaaaatctct aaggggaaag aaattatttt tgccttcact     4020

ttttcttctg tgaaaagtta attcctgctt taagtagcaa ttattgaaat atatagagaa     4080

agagagaatt aacattggtc taaattgttg aaatataaat aatggctaat tttctatgaa     4140

aaatttgcca tgaataaaat gccttatgaa gaacggcttc tttgccaaaa ataaaacaca     4200

attgatgacc aattcaattt tgatggggta atgaattgat ggtttgaaaa tagtaactaa     4260

gaaattatta aactaaaggt gcttgaggga gaaattagaa tatgtgacat atttcctcat     4320

aaatgtaagc aagcccttaa taaatgcttt gatgtaatgt tccttttgtt cacagtacag     4380

ttatgtagtg ctagccagat atttaaaaat gctctaagaa aagcttgtca ggggggaggg     4440

ggaaatgttt ttcttgtgat aaatgaactt tggtttacca agggtatttt gcatgatgct     4500

gctgctattt taacttttca gttgtttttt ctcttactgt agagtgtagt cattgaaaag     4560

ttaactgagt gatattgtta tgtaagaatc tgaaccttgc agtgtaaatg cacttaagtc     4620

atctttaaaa tgttgttaaa ctactctgaa tatactgtgc aatgtaaatg ctgaatgatt     4680

ggggttagat aaatggtgaa atgagaatta atgaatttta tacagattca tgctttcgcc     4740

tgataaccta tgtacagata ttttaagtac ataaatcaga tttgacacat ttattttttg     4800

aaaagtacat atatgttctc aatgaagatt catcctaggt ttcctctttg ttcgtttcaa     4860

tagtagcaca tacaatccaa aagttcctgc tactgctgct tttgcccttc cattttaaat     4920

ggtatgatcg tttggccaaa atttccatgc aagttgataa gggttttaca ataatctgaa     4980

caaataggaa accttgaatc tctatgtatg cacatgaata cttgattgtg aataataaaa     5040

gttgtttttt atacagcctc attggtgaaa atggttagtg tagtaaatca gatatttcat     5100

tatagactaa tatggtagca gattatttat gcttttaaaa attattttct ggagcaaaca     5160

gtatttgaag aaaaggtaaa aactatgaat gtgtaattct aagaatagtt aataatttta     5220

ctgaaggctg aacgtatgta gatatttttt atgataaaat gcagtttttc tttttttgga     5280

acatgccaat tactggtatg tgtatatgct ggaaattttc ttacatatcc tttttaagtc     5340

aaagttatta acattatcca gcatgcttta atatgctcca catatcaaag atataaccaa     5400

taatttaacg tagcttaaaa gataacattt gttttgtttt tagctttgca tacatttgta     5460

attccctccc accaccaata taccttaggt accatttgtg tacatttcaa gatttttttt     5520

ttcaataaaa aggtgggggg aaatggaatc actttgccaa ctattgttct aagagttgac     5580

atcagttacc atttctaatg cattgttgtg attttgtagt gtcattcata actggtattg     5640

acattttaga aaacaccaaa gtgatttaaa atatatgtgg ggaaaaaaac ttctcactct     5700

agtaacaatg ttttaatcat gttgtttgtt aaatatttaa aagttattgt tcaatttttg     5760

ctagactatc ttaaatcatg atagtgttgg gaagggggta tcaaaatata aaattgttag     5820

tttgtgtata taaacaatgc acattaaaac aattgaattg cttccagcat acaacaaact     5880

accttaaaat tatgttcaaa atctattaaa tatattttca tggctaatgt cgagtatatg     5940

ttttcatcaa ttacattgtt attgtattaa tcgcggttaa acttggcatc tcttggcagg     6000

atcctattta atttctgttg ccatcaaaat atatttatat gcatgagttt tgctataaac     6060

ctttattttc tgctataaag ttatatatta tgacaaccat aaatgcaatt acaaattggg     6120

taagaacaag ctgaataaaa gttgttccca tgactaatat tagtcttcat gcttttagca     6180

tattttttaa gacagtaaca ctcatcccat caaattatta cattacattt agtatttttc     6240

tgagttacat tgacaagaac ttaaattata gcctgttatt aatattgatt tccaacgact     6300

gaacagtaca acagatcaat aaaaaagttt atacactgct ttaactaatt tttgttatac     6360

tcatgtggct tagtgtagtt agtcactaaa acagagttca agtgagcttg gcaatggtgt     6420

tgagtaacaa gaaagaattt tgcattaatg atttcttttt attttcctca tttaaacaac     6480

cagcattact gccaaacacc aaccgtggtc catatttgta acaggttttt aacatgacat     6540

agttagcaag tttgattgaa gagattttta ggtcctgggc ctataagatt ttagtatgat     6600

cttttttcat gtttctaatg cttgaggtgt tactgcttaa cttgggaaaa aaaaaaacaa     6660

aaaacagtgt tcctgccatt tgtaagtttt cctataatat tccttttatt aactttaaaa     6720

ctggacttat cgggttcaaa taggcagtat cccttttaag tgacctttgc aacccaagtg     6780

ttacttgctt atttgatgct ctcttgtatt ttaaatctca tttaaatctt tgtctgtgac     6840

caacaaagct taagattttg tcttcattta aaactctgaa tctattccat tgatcatgtt     6900

agacgttcaa atgtttaatg gtatagtctg acctagtgaa acaaaatgga tgttgttact     6960

ttttttaaag aatagaatga aataactatt tcacttgccc aaaattttaa atattttttc     7020

atctaaactt gtattgtttc ccatagcaga atgtcaatat tcacagtaca tttctgtaaa     7080

gagcaaacca atataatgtt ttgagtgttg aaaaaaattc cagatttttg aagaattaga     7140

caactcttca tctaccttat ttctagttca cacagttatc tcaaattcca ctgaaactaa     7200

tgggatactg tcttgtgtag atgccagttg agtttataat gtgacctagt aaagctgtct     7260

tttttgttgt gttgtatgag tgtcggatca tgcttttagg aatactttta ttaaaatggt     7320

gtgcattcat gcaaaaggcc aactggcttt tgtgaacaat agatcttttc tcccctttat     7380

tttgttctct tgacactttt gtgaaaatta cctagcctga taaaaacatt ttgtaaaaat     7440

ttgtataata ctgttataaa atatttataa tcccagaaaa tgttgtgtta aatcttgtgc     7500

aaaaacagta tattcagaat aaaagtttat catttaaagt ca                        7542


<210>  29
<211>  2181
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Met Met Met Met Met Met Lys Lys Met Gln His Gln Arg Gln Gln 
1               5                   10                  15      


Gln Ala Asp His Ala Asn Glu Ala Asn Tyr Ala Arg Gly Thr Arg Leu 
            20                  25                  30          


Pro Leu Ser Gly Glu Gly Pro Thr Ser Gln Pro Asn Ser Ser Lys Gln 
        35                  40                  45              


Thr Val Leu Ser Trp Gln Ala Ala Ile Asp Ala Ala Arg Gln Ala Lys 
    50                  55                  60                  


Ala Ala Gln Thr Met Ser Thr Ser Ala Pro Pro Pro Val Gly Ser Leu 
65                  70                  75                  80  


Ser Gln Arg Lys Arg Gln Gln Tyr Ala Lys Ser Lys Lys Gln Gly Asn 
                85                  90                  95      


Ser Ser Asn Ser Arg Pro Ala Arg Ala Leu Phe Cys Leu Ser Leu Asn 
            100                 105                 110         


Asn Pro Ile Arg Arg Ala Cys Ile Ser Ile Val Glu Trp Lys Pro Phe 
        115                 120                 125             


Asp Ile Phe Ile Leu Leu Ala Ile Phe Ala Asn Cys Val Ala Leu Ala 
    130                 135                 140                 


Ile Tyr Ile Pro Phe Pro Glu Asp Asp Ser Asn Ser Thr Asn His Asn 
145                 150                 155                 160 


Leu Glu Lys Val Glu Tyr Ala Phe Leu Ile Ile Phe Thr Val Glu Thr 
                165                 170                 175     


Phe Leu Lys Ile Ile Ala Tyr Gly Leu Leu Leu His Pro Asn Ala Tyr 
            180                 185                 190         


Val Arg Asn Gly Trp Asn Leu Leu Asp Phe Val Ile Val Ile Val Gly 
        195                 200                 205             


Leu Phe Ser Val Ile Leu Glu Gln Leu Thr Lys Glu Thr Glu Gly Gly 
    210                 215                 220                 


Asn His Ser Ser Gly Lys Ser Gly Gly Phe Asp Val Lys Ala Leu Arg 
225                 230                 235                 240 


Ala Phe Arg Val Leu Arg Pro Leu Arg Leu Val Ser Gly Val Pro Ser 
                245                 250                 255     


Leu Gln Val Val Leu Asn Ser Ile Ile Lys Ala Met Val Pro Leu Leu 
            260                 265                 270         


His Ile Ala Leu Leu Val Leu Phe Val Ile Ile Ile Tyr Ala Ile Ile 
        275                 280                 285             


Gly Leu Glu Leu Phe Ile Gly Lys Met His Lys Thr Cys Phe Phe Ala 
    290                 295                 300                 


Asp Ser Asp Ile Val Ala Glu Glu Asp Pro Ala Pro Cys Ala Phe Ser 
305                 310                 315                 320 


Gly Asn Gly Arg Gln Cys Thr Ala Asn Gly Thr Glu Cys Arg Ser Gly 
                325                 330                 335     


Trp Val Gly Pro Asn Gly Gly Ile Thr Asn Phe Asp Asn Phe Ala Phe 
            340                 345                 350         


Ala Met Leu Thr Val Phe Gln Cys Ile Thr Met Glu Gly Trp Thr Asp 
        355                 360                 365             


Val Leu Tyr Trp Val Asn Asp Ala Ile Gly Trp Glu Trp Pro Trp Val 
    370                 375                 380                 


Tyr Phe Val Ser Leu Ile Ile Leu Gly Ser Phe Phe Val Leu Asn Leu 
385                 390                 395                 400 


Val Leu Gly Val Leu Ser Gly Glu Phe Ser Lys Glu Arg Glu Lys Ala 
                405                 410                 415     


Lys Ala Arg Gly Asp Phe Gln Lys Leu Arg Glu Lys Gln Gln Leu Glu 
            420                 425                 430         


Glu Asp Leu Lys Gly Tyr Leu Asp Trp Ile Thr Gln Ala Glu Asp Ile 
        435                 440                 445             


Asp Pro Glu Asn Glu Glu Glu Gly Gly Glu Glu Gly Lys Arg Asn Thr 
    450                 455                 460                 


Ser Met Pro Thr Ser Glu Thr Glu Ser Val Asn Thr Glu Asn Val Ser 
465                 470                 475                 480 


Gly Glu Gly Glu Asn Arg Gly Cys Cys Gly Ser Leu Trp Cys Trp Trp 
                485                 490                 495     


Arg Arg Arg Gly Ala Ala Lys Ala Gly Pro Ser Gly Cys Arg Arg Trp 
            500                 505                 510         


Gly Gln Ala Ile Ser Lys Ser Lys Leu Ser Arg Arg Trp Arg Arg Trp 
        515                 520                 525             


Asn Arg Phe Asn Arg Arg Arg Cys Arg Ala Ala Val Lys Ser Val Thr 
    530                 535                 540                 


Phe Tyr Trp Leu Val Ile Val Leu Val Phe Leu Asn Thr Leu Thr Ile 
545                 550                 555                 560 


Ser Ser Glu His Tyr Asn Gln Pro Asp Trp Leu Thr Gln Ile Gln Asp 
                565                 570                 575     


Ile Ala Asn Lys Val Leu Leu Ala Leu Phe Thr Cys Glu Met Leu Val 
            580                 585                 590         


Lys Met Tyr Ser Leu Gly Leu Gln Ala Tyr Phe Val Ser Leu Phe Asn 
        595                 600                 605             


Arg Phe Asp Cys Phe Val Val Cys Gly Gly Ile Thr Glu Thr Ile Leu 
    610                 615                 620                 


Val Glu Leu Glu Ile Met Ser Pro Leu Gly Ile Ser Val Phe Arg Cys 
625                 630                 635                 640 


Val Arg Leu Leu Arg Ile Phe Lys Val Thr Arg His Trp Thr Ser Leu 
                645                 650                 655     


Ser Asn Leu Val Ala Ser Leu Leu Asn Ser Met Lys Ser Ile Ala Ser 
            660                 665                 670         


Leu Leu Leu Leu Leu Phe Leu Phe Ile Ile Ile Phe Ser Leu Leu Gly 
        675                 680                 685             


Met Gln Leu Phe Gly Gly Lys Phe Asn Phe Asp Glu Thr Gln Thr Lys 
    690                 695                 700                 


Arg Ser Thr Phe Asp Asn Phe Pro Gln Ala Leu Leu Thr Val Phe Gln 
705                 710                 715                 720 


Ile Leu Thr Gly Glu Asp Trp Asn Ala Val Met Tyr Asp Gly Ile Met 
                725                 730                 735     


Ala Tyr Gly Gly Pro Ser Ser Ser Gly Met Ile Val Cys Ile Tyr Phe 
            740                 745                 750         


Ile Ile Leu Phe Ile Cys Gly Asn Tyr Ile Leu Leu Asn Val Phe Leu 
        755                 760                 765             


Ala Ile Ala Val Asp Asn Leu Ala Asp Ala Glu Ser Leu Asn Thr Ala 
    770                 775                 780                 


Gln Lys Glu Glu Ala Glu Glu Lys Glu Arg Lys Lys Ile Ala Arg Lys 
785                 790                 795                 800 


Glu Ser Leu Glu Asn Lys Lys Asn Asn Lys Pro Glu Val Asn Gln Ile 
                805                 810                 815     


Ala Asn Ser Asp Asn Lys Val Thr Ile Asp Asp Tyr Arg Glu Glu Asp 
            820                 825                 830         


Glu Asp Lys Asp Pro Tyr Pro Pro Cys Asp Val Pro Val Gly Glu Glu 
        835                 840                 845             


Glu Glu Glu Glu Glu Glu Asp Glu Pro Glu Val Pro Ala Gly Pro Arg 
    850                 855                 860                 


Pro Arg Arg Ile Ser Glu Leu Asn Met Lys Glu Lys Ile Ala Pro Ile 
865                 870                 875                 880 


Pro Glu Gly Ser Ala Phe Phe Ile Leu Ser Lys Thr Asn Pro Ile Arg 
                885                 890                 895     


Val Gly Cys His Lys Leu Ile Asn His His Ile Phe Thr Asn Leu Ile 
            900                 905                 910         


Leu Val Phe Ile Met Leu Ser Ser Ala Ala Leu Ala Ala Glu Asp Pro 
        915                 920                 925             


Ile Arg Ser His Ser Phe Arg Asn Thr Ile Leu Gly Tyr Phe Asp Tyr 
    930                 935                 940                 


Ala Phe Thr Ala Ile Phe Thr Val Glu Ile Leu Leu Lys Met Thr Thr 
945                 950                 955                 960 


Phe Gly Ala Phe Leu His Lys Gly Ala Phe Cys Arg Asn Tyr Phe Asn 
                965                 970                 975     


Leu Leu Asp Met Leu Val Val Gly Val Ser Leu Val Ser Phe Gly Ile 
            980                 985                 990         


Gln Ser Ser Ala Ile Ser Val Val  Lys Ile Leu Arg Val  Leu Arg Val 
        995                 1000                 1005             


Leu Arg  Pro Leu Arg Ala Ile  Asn Arg Ala Lys Gly  Leu Lys His 
    1010                 1015                 1020             


Val Val  Gln Cys Val Phe Val  Ala Ile Arg Thr Ile  Gly Asn Ile 
    1025                 1030                 1035             


Met Ile  Val Thr Thr Leu Leu  Gln Phe Met Phe Ala  Cys Ile Gly 
    1040                 1045                 1050             


Val Gln  Leu Phe Lys Gly Lys  Phe Tyr Arg Cys Thr  Asp Glu Ala 
    1055                 1060                 1065             


Lys Ser  Asn Pro Glu Glu Cys  Arg Gly Leu Phe Ile  Leu Tyr Lys 
    1070                 1075                 1080             


Asp Gly  Asp Val Asp Ser Pro  Val Val Arg Glu Arg  Ile Trp Gln 
    1085                 1090                 1095             


Asn Ser  Asp Phe Asn Phe Asp  Asn Val Leu Ser Ala  Met Met Ala 
    1100                 1105                 1110             


Leu Phe  Thr Val Ser Thr Phe  Glu Gly Trp Pro Ala  Leu Leu Tyr 
    1115                 1120                 1125             


Lys Ala  Ile Asp Ser Asn Gly  Glu Asn Ile Gly Pro  Ile Tyr Asn 
    1130                 1135                 1140             


His Arg  Val Glu Ile Ser Ile  Phe Phe Ile Ile Tyr  Ile Ile Ile 
    1145                 1150                 1155             


Val Ala  Phe Phe Met Met Asn  Ile Phe Val Gly Phe  Val Ile Val 
    1160                 1165                 1170             


Thr Phe  Gln Glu Gln Gly Glu  Lys Glu Tyr Lys Asn  Cys Glu Leu 
    1175                 1180                 1185             


Asp Lys  Asn Gln Arg Gln Cys  Val Glu Tyr Ala Leu  Lys Ala Arg 
    1190                 1195                 1200             


Pro Leu  Arg Arg Tyr Ile Pro  Lys Asn Pro Tyr Gln  Tyr Lys Phe 
    1205                 1210                 1215             


Trp Tyr  Val Val Asn Ser Ser  Pro Phe Glu Tyr Met  Met Phe Val 
    1220                 1225                 1230             


Leu Ile  Met Leu Asn Thr Leu  Cys Leu Ala Met Gln  His Tyr Glu 
    1235                 1240                 1245             


Gln Ser  Lys Met Phe Asn Asp  Ala Met Asp Ile Leu  Asn Met Val 
    1250                 1255                 1260             


Phe Thr  Gly Val Phe Thr Val  Glu Met Val Leu Lys  Val Ile Ala 
    1265                 1270                 1275             


Phe Lys  Pro Lys Gly Tyr Phe  Ser Asp Ala Trp Asn  Thr Phe Asp 
    1280                 1285                 1290             


Ser Leu  Ile Val Ile Gly Ser  Ile Ile Asp Val Ala  Leu Ser Glu 
    1295                 1300                 1305             


Ala Asp  Pro Thr Glu Ser Glu  Asn Val Pro Val Pro  Thr Ala Thr 
    1310                 1315                 1320             


Pro Gly  Asn Ser Glu Glu Ser  Asn Arg Ile Ser Ile  Thr Phe Phe 
    1325                 1330                 1335             


Arg Leu  Phe Arg Val Met Arg  Leu Val Lys Leu Leu  Ser Arg Gly 
    1340                 1345                 1350             


Glu Gly  Ile Arg Thr Leu Leu  Trp Thr Phe Ile Lys  Ser Phe Gln 
    1355                 1360                 1365             


Ala Leu  Pro Tyr Val Ala Leu  Leu Ile Ala Met Leu  Phe Phe Ile 
    1370                 1375                 1380             


Tyr Ala  Val Ile Gly Met Gln  Met Phe Gly Lys Val  Ala Met Arg 
    1385                 1390                 1395             


Asp Asn  Asn Gln Ile Asn Arg  Asn Asn Asn Phe Gln  Thr Phe Pro 
    1400                 1405                 1410             


Gln Ala  Val Leu Leu Leu Phe  Arg Cys Ala Thr Gly  Glu Ala Trp 
    1415                 1420                 1425             


Gln Glu  Ile Met Leu Ala Cys  Leu Pro Gly Lys Leu  Cys Asp Pro 
    1430                 1435                 1440             


Glu Ser  Asp Tyr Asn Pro Gly  Glu Glu Tyr Thr Cys  Gly Ser Asn 
    1445                 1450                 1455             


Phe Ala  Ile Val Tyr Phe Ile  Ser Phe Tyr Met Leu  Cys Ala Phe 
    1460                 1465                 1470             


Leu Ile  Ile Asn Leu Phe Val  Ala Val Ile Met Asp  Asn Phe Asp 
    1475                 1480                 1485             


Tyr Leu  Thr Arg Asp Trp Ser  Ile Leu Gly Pro His  His Leu Asp 
    1490                 1495                 1500             


Glu Phe  Lys Arg Ile Trp Ser  Glu Tyr Asp Pro Glu  Ala Lys Gly 
    1505                 1510                 1515             


Arg Ile  Lys His Leu Asp Val  Val Thr Leu Leu Arg  Arg Ile Gln 
    1520                 1525                 1530             


Pro Pro  Leu Gly Phe Gly Lys  Leu Cys Pro His Arg  Val Ala Cys 
    1535                 1540                 1545             


Lys Arg  Leu Val Ala Met Asn  Met Pro Leu Asn Ser  Asp Gly Thr 
    1550                 1555                 1560             


Val Met  Phe Asn Ala Thr Leu  Phe Ala Leu Val Arg  Thr Ala Leu 
    1565                 1570                 1575             


Lys Ile  Lys Thr Glu Gly Asn  Leu Glu Gln Ala Asn  Glu Glu Leu 
    1580                 1585                 1590             


Arg Ala  Val Ile Lys Lys Ile  Trp Lys Lys Thr Ser  Met Lys Leu 
    1595                 1600                 1605             


Leu Asp  Gln Val Val Pro Pro  Ala Gly Asp Asp Glu  Val Thr Val 
    1610                 1615                 1620             


Gly Lys  Phe Tyr Ala Thr Phe  Leu Ile Gln Asp Tyr  Phe Arg Lys 
    1625                 1630                 1635             


Phe Lys  Lys Arg Lys Glu Gln  Gly Leu Val Gly Lys  Tyr Pro Ala 
    1640                 1645                 1650             


Lys Asn  Thr Thr Ile Ala Leu  Gln Ala Gly Leu Arg  Thr Leu His 
    1655                 1660                 1665             


Asp Ile  Gly Pro Glu Ile Arg  Arg Ala Ile Ser Cys  Asp Leu Gln 
    1670                 1675                 1680             


Asp Asp  Glu Pro Glu Glu Thr  Lys Arg Glu Glu Glu  Asp Asp Val 
    1685                 1690                 1695             


Phe Lys  Arg Asn Gly Ala Leu  Leu Gly Asn His Val  Asn His Val 
    1700                 1705                 1710             


Asn Ser  Asp Arg Arg Asp Ser  Leu Gln Gln Thr Asn  Thr Thr His 
    1715                 1720                 1725             


Arg Pro  Leu His Val Gln Arg  Pro Ser Ile Pro Pro  Ala Ser Asp 
    1730                 1735                 1740             


Thr Glu  Lys Pro Leu Phe Pro  Pro Ala Gly Asn Ser  Val Cys His 
    1745                 1750                 1755             


Asn His  His Asn His Asn Ser  Ile Gly Lys Gln Val  Pro Thr Ser 
    1760                 1765                 1770             


Thr Asn  Ala Asn Leu Asn Asn  Ala Asn Met Ser Lys  Ala Ala His 
    1775                 1780                 1785             


Gly Lys  Arg Pro Ser Ile Gly  Asn Leu Glu His Val  Ser Glu Asn 
    1790                 1795                 1800             


Gly His  His Ser Ser His Lys  His Asp Arg Glu Pro  Gln Arg Arg 
    1805                 1810                 1815             


Ser Ser  Val Lys Arg Thr Arg  Tyr Tyr Glu Thr Tyr  Ile Arg Ser 
    1820                 1825                 1830             


Asp Ser  Gly Asp Glu Gln Leu  Pro Thr Ile Cys Arg  Glu Asp Pro 
    1835                 1840                 1845             


Glu Ile  His Gly Tyr Phe Arg  Asp Pro His Cys Leu  Gly Glu Gln 
    1850                 1855                 1860             


Glu Tyr  Phe Ser Ser Glu Glu  Cys Tyr Glu Asp Asp  Ser Ser Pro 
    1865                 1870                 1875             


Thr Trp  Ser Arg Gln Asn Tyr  Gly Tyr Tyr Ser Arg  Tyr Pro Gly 
    1880                 1885                 1890             


Arg Asn  Ile Asp Ser Glu Arg  Pro Arg Gly Tyr His  His Pro Gln 
    1895                 1900                 1905             


Gly Phe  Leu Glu Asp Asp Asp  Ser Pro Val Cys Tyr  Asp Ser Arg 
    1910                 1915                 1920             


Arg Ser  Pro Arg Arg Arg Leu  Leu Pro Pro Thr Pro  Ala Ser His 
    1925                 1930                 1935             


Arg Arg  Ser Ser Phe Asn Phe  Glu Cys Leu Arg Arg  Gln Ser Ser 
    1940                 1945                 1950             


Gln Glu  Glu Val Pro Ser Ser  Pro Ile Phe Pro His  Arg Thr Ala 
    1955                 1960                 1965             


Leu Pro  Leu His Leu Met Gln  Gln Gln Ile Met Ala  Val Ala Gly 
    1970                 1975                 1980             


Leu Asp  Ser Ser Lys Ala Gln  Lys Tyr Ser Pro Ser  His Ser Thr 
    1985                 1990                 1995             


Arg Ser  Trp Ala Thr Pro Pro  Ala Thr Pro Pro Tyr  Arg Asp Trp 
    2000                 2005                 2010             


Thr Pro  Cys Tyr Thr Pro Leu  Ile Gln Val Glu Gln  Ser Glu Ala 
    2015                 2020                 2025             


Leu Asp  Gln Val Asn Gly Ser  Leu Pro Ser Leu His  Arg Ser Ser 
    2030                 2035                 2040             


Trp Tyr  Thr Asp Glu Pro Asp  Ile Ser Tyr Arg Thr  Phe Thr Pro 
    2045                 2050                 2055             


Ala Ser  Leu Thr Val Pro Ser  Ser Phe Arg Asn Lys  Asn Ser Asp 
    2060                 2065                 2070             


Lys Gln  Arg Ser Ala Asp Ser  Leu Val Glu Ala Val  Leu Ile Ser 
    2075                 2080                 2085             


Glu Gly  Leu Gly Arg Tyr Ala  Arg Asp Pro Lys Phe  Val Ser Ala 
    2090                 2095                 2100             


Thr Lys  His Glu Ile Ala Asp  Ala Cys Asp Leu Thr  Ile Asp Glu 
    2105                 2110                 2115             


Met Glu  Ser Ala Ala Ser Thr  Leu Leu Asn Gly Asn  Val Arg Pro 
    2120                 2125                 2130             


Arg Ala  Asn Gly Asp Val Gly  Pro Leu Ser His Arg  Gln Asp Tyr 
    2135                 2140                 2145             


Glu Leu  Gln Asp Phe Gly Pro  Gly Tyr Ser Asp Glu  Glu Pro Asp 
    2150                 2155                 2160             


Pro Gly  Arg Asp Glu Glu Asp  Leu Ala Asp Glu Met  Ile Cys Ile 
    2165                 2170                 2175             


Thr Thr  Leu 
    2180     


<210>  30
<211>  7726
<212>  DNA
<213>  Homo sapiens

<400>  30
agaataaggg cagggaccgc ggctcctacc tcttggtgat ccccttcccc attccgcccc       60

cgcctcaacg cccagcacag tgccctgcac acagtagtcg ctcaataaat gttcgtggat      120

gatgatgatg atgatgatga aaaaaatgca gcatcaacgg cagcagcaag cggaccacgc      180

gaacgaggca aactatgcaa gaggcaccag acttcctctt tctggtgaag gaccaacttc      240

tcagccgaat agctccaagc aaactgtcct gtcttggcaa gctgcaatcg atgctgctag      300

acaggccaag gctgcccaaa ctatgagcac ctctgcaccc ccacctgtag gatctctctc      360

ccaaagaaaa cgtcagcaat acgccaagag caaaaaacag ggtaactcgt ccaacagccg      420

acctgcccgc gcccttttct gtttatcact caataacccc atccgaagag cctgcattag      480

tatagtggaa tggaaaccat ttgacatatt tatattattg gctatttttg ccaattgtgt      540

ggccttagct atttacatcc cattccctga agatgattct aattcaacaa atcataactt      600

ggaaaaagta gaatatgcct tcctgattat ttttacagtc gagacatttt tgaagattat      660

agcgtatgga ttattgctac atcctaatgc ttatgttagg aatggatgga atttactgga      720

ttttgttata gtaatagtag gattgtttag tgtaattttg gaacaattaa ccaaagaaac      780

agaaggcggg aaccactcaa gcggcaaatc tggaggcttt gatgtcaaag ccctccgtgc      840

ctttcgagtg ttgcgaccac ttcgactagt gtcaggagtg cccagtttac aagttgtcct      900

gaactccatt ataaaagcca tggttcccct ccttcacata gcccttttgg tattatttgt      960

aatcataatc tatgctatta taggattgga actttttatt ggaaaaatgc acaaaacatg     1020

tttttttgct gactcagata tcgtagctga agaggaccca gctccatgtg cgttctcagg     1080

gaatggacgc cagtgtactg ccaatggcac ggaatgtagg agtggctggg ttggcccgaa     1140

cggaggcatc accaactttg ataactttgc ctttgccatg cttactgtgt ttcagtgcat     1200

caccatggag ggctggacag atgtgctcta ctgggtaaat gatgcgatag gatgggaatg     1260

gccatgggtg tattttgtta gtctgatcat ccttggctca tttttcgtcc ttaacctggt     1320

tcttggtgtc cttagtggag aattctcaaa ggaaagagag aaggcaaaag cacggggaga     1380

tttccagaag ctccgggaga agcagcagct ggaggaggat ctaaagggct acttggattg     1440

gatcacccaa gctgaggaca tcgatccgga gaatgaggaa gaaggaggag aggaaggcaa     1500

acgaaatact agcatgccca ccagcgagac tgagtctgtg aacacagaga acgtcagcgg     1560

tgaaggcgag aaccgaggct gctgtggaag tctctggtgc tggtggagac ggagaggcgc     1620

ggccaaggcg gggccctctg ggtgtcggcg gtggggtcaa gccatctcaa aatccaaact     1680

cagccgacgc tggcgtcgct ggaaccgatt caatcgcaga agatgtaggg ccgccgtgaa     1740

gtctgtcacg ttttactggc tggttatcgt cctggtgttt ctgaacacct taaccatttc     1800

ctctgagcac tacaatcagc cagattggtt gacacagatt caagatattg ccaacaaagt     1860

cctcttggct ctgttcacct gcgagatgct ggtaaaaatg tacagcttgg gcctccaagc     1920

atatttcgtc tctcttttca accggtttga ttgcttcgtg gtgtgtggtg gaatcactga     1980

gacgatcttg gtggaactgg aaatcatgtc tcccctgggg atctctgtgt ttcggtgtgt     2040

gcgcctctta agaatcttca aagtgaccag gcactggact tccctgagca acttagtggc     2100

atccttatta aactccatga agtccatcgc ttcgctgttg cttctgcttt ttctcttcat     2160

tatcatcttt tccttgcttg ggatgcagct gtttggcggc aagtttaatt ttgatgaaac     2220

gcaaaccaag cggagcacct ttgacaattt ccctcaagca cttctcacag tgttccagat     2280

cctgacaggc gaagactgga atgctgtgat gtacgatggc atcatggctt acgggggccc     2340

atcctcttca ggaatgatcg tctgcatcta cttcatcatc ctcttcattt gtggtaacta     2400

tattctactg aatgtcttct tggccatcgc tgtagacaat ttggctgatg ctgaaagtct     2460

gaacactgct cagaaagaag aagcggaaga aaaggagagg aaaaagattg ccagaaaaga     2520

gagcctagaa aataaaaaga acaacaaacc agaagtcaac cagatagcca acagtgacaa     2580

caaggttaca attgatgact atagagaaga ggatgaagac aaggacccct atccgccttg     2640

cgatgtgcca gtaggggaag aggaagagga agaggaggag gatgaacctg aggttcctgc     2700

cggaccccgt cctcgaagga tctcggagtt gaacatgaag gaaaaaattg cccccatccc     2760

tgaagggagc gctttcttca ttcttagcaa gaccaacccg atccgcgtag gctgccacaa     2820

gctcatcaac caccacatct tcaccaacct catccttgtc ttcatcatgc tgagcagcgc     2880

tgccctggcc gcagaggacc ccatccgcag ccactccttc cggaacacga tactgggtta     2940

ctttgactat gccttcacag ccatctttac tgttgagatc ctgttgaaga tgacaacttt     3000

tggagctttc ctccacaaag gggccttctg caggaactac ttcaatttgc tggatatgct     3060

ggtggttggg gtgtctctgg tgtcatttgg gattcaatcc agtgccatct ccgttgtgaa     3120

gattctgagg gtcttaaggg tcctgcgtcc cctcagggcc atcaacagag caaaaggact     3180

taagcacgtg gtccagtgcg tcttcgtggc catccggacc atcggcaaca tcatgatcgt     3240

caccaccctc ctgcagttca tgtttgcctg tatcggggtc cagttgttca aggggaagtt     3300

ctatcgctgt acggatgaag ccaaaagtaa ccctgaagaa tgcaggggac ttttcatcct     3360

ctacaaggat ggggatgttg acagtcctgt ggtccgtgaa cggatctggc aaaacagtga     3420

tttcaacttc gacaacgtcc tctctgctat gatggcgctc ttcacagtct ccacgtttga     3480

gggctggcct gcgttgctgt ataaagccat cgactcgaat ggagagaaca tcggcccaat     3540

ctacaaccac cgcgtggaga tctccatctt cttcatcatc tacatcatca ttgtagcttt     3600

cttcatgatg aacatctttg tgggctttgt catcgttaca tttcaggaac aaggagaaaa     3660

agagtataag aactgtgagc tggacaaaaa tcagcgtcag tgtgttgaat acgccttgaa     3720

agcacgtccc ttgcggagat acatccccaa aaacccctac cagtacaagt tctggtacgt     3780

ggtgaactct tcgcctttcg aatacatgat gtttgtcctc atcatgctca acacactctg     3840

cttggccatg cagcactacg agcagtccaa gatgttcaat gatgccatgg acattctgaa     3900

catggtcttc accggggtgt tcaccgtcga gatggttttg aaagtcatcg catttaagcc     3960

taaggggtat tttagtgacg cctggaacac gtttgactcc ctcatcgtaa tcggcagcat     4020

tatagacgtg gccctcagcg aagcagaccc aactgaaagt gaaaatgtcc ctgtcccaac     4080

tgctacacct gggaactctg aagagagcaa tagaatctcc atcacctttt tccgtctttt     4140

ccgagtgatg cgattggtga agcttctcag caggggggaa ggcatccgga cattgctgtg     4200

gacttttatt aagtcctttc aggcgctccc gtatgtggcc ctcctcatag ccatgctgtt     4260

cttcatctat gcggtcattg gcatgcagat gtttgggaaa gttgccatga gagataacaa     4320

ccagatcaat aggaacaata acttccagac gtttccccag gcggtgctgc tgctcttcag     4380

gtgtgcaaca ggtgaggcct ggcaggagat catgctggcc tgtctcccag ggaagctctg     4440

tgaccctgag tcagattaca accccgggga ggagtataca tgtgggagca actttgccat     4500

tgtctatttc atcagttttt acatgctctg tgcatttctg atcatcaatc tgtttgtggc     4560

tgtcatcatg gataatttcg actatctgac ccgggactgg tctattttgg ggcctcacca     4620

tttagatgaa ttcaaaagaa tatggtcaga atatgaccct gaggcaaagg gaaggataaa     4680

acaccttgat gtggtcactc tgcttcgacg catccagcct cccctggggt ttgggaagtt     4740

atgtccacac agggtagcgt gcaagagatt agttgccatg aacatgcctc tcaacagtga     4800

cgggacagtc atgtttaatg caaccctgtt tgctttggtt cgaacggctc ttaagatcaa     4860

gaccgaaggg aacctggagc aagctaatga agaacttcgg gctgtgataa agaaaatttg     4920

gaagaaaacc agcatgaaat tacttgacca agttgtccct ccagctggtg atgatgaggt     4980

aaccgtgggg aagttctatg ccactttcct gatacaggac tactttagga aattcaagaa     5040

acggaaagaa caaggactgg tgggaaagta ccctgcgaag aacaccacaa ttgccctaca     5100

ggcgggatta aggacactgc atgacattgg gccagaaatc cggcgtgcta tatcgtgtga     5160

tttgcaagat gacgagcctg aggaaacaaa acgagaagaa gaagatgatg tgttcaaaag     5220

aaatggtgcc ctgcttggaa accatgtcaa tcatgttaat agtgatagga gagattccct     5280

tcagcagacc aataccaccc accgtcccct gcatgtccaa aggccttcaa ttccacctgc     5340

aagtgatact gagaaaccgc tgtttcctcc agcaggaaat tcggtgtgtc ataaccatca     5400

taaccataat tccataggaa agcaagttcc cacctcaaca aatgccaatc tcaataatgc     5460

caatatgtcc aaagctgccc atggaaagcg gcccagcatt gggaaccttg agcatgtgtc     5520

tgaaaatggg catcattctt cccacaagca tgaccgggag cctcagagaa ggtccagtgt     5580

gaaaagaacc cgctattatg aaacttacat taggtccgac tcaggagatg aacagctccc     5640

aactatttgc cgggaagacc cagagataca tggctatttc agggaccccc actgcttggg     5700

ggagcaggag tatttcagta gtgaggaatg ctacgaggat gacagctcgc ccacctggag     5760

caggcaaaac tatggctact acagcagata cccaggcaga aacatcgact ctgagaggcc     5820

ccgaggctac catcatcccc aaggattctt ggaggacgat gactcgcccg tttgctatga     5880

ttcacggaga tctccaagga gacgcctact acctcccacc ccagcatccc accggagatc     5940

ctccttcaac tttgagtgcc tgcgccggca gagcagccag gaagaggtcc cgtcgtctcc     6000

catcttcccc catcgcacgg ccctgcctct gcatctaatg cagcaacaga tcatggcagt     6060

tgccggccta gattcaagta aagcccagaa gtactcaccg agtcactcga cccggtcgtg     6120

ggccacccct ccagcaaccc ctccctaccg ggactggaca ccgtgctaca cccccctgat     6180

ccaagtggag cagtcagagg ccctggacca ggtgaacggc agcctgccgt ccctgcaccg     6240

cagctcctgg tacacagacg agcccgacat ctcctaccgg actttcacac cagccagcct     6300

gactgtcccc agcagcttcc ggaacaaaaa cagcgacaag cagaggagtg cggacagctt     6360

ggtggaggca gtcctgatat ccgaaggctt gggacgctat gcaagggacc caaaatttgt     6420

gtcagcaaca aaacacgaaa tcgctgatgc ctgtgacctc accatcgacg agatggagag     6480

tgcagccagc accctgctta atgggaacgt gcgtccccga gccaacgggg atgtgggccc     6540

cctctcacac cggcaggact atgagctaca ggactttggt cctggctaca gcgacgaaga     6600

gccagaccct gggagggatg aggaggacct ggcggatgaa atgatatgca tcaccacctt     6660

gtagccccca gcgaggggca gactggctct ggcctcaggt ggggcgcagg agagccaggg     6720

gaaaagtgcc tcatagttag gaaagtttag gcactagttg ggagtaatat tcaattaatt     6780

agacttttgt ataagagatg tcatgcctca agaaagccat aaacctggta ggaacaggtc     6840

ccaagcggtt gagcctggca gagtaccatg cgctcggccc cagctgcagg aaacagcagg     6900

ccccgccctc tcacagagga tgggtgagga ggccagacct gccctgcccc attgtccaga     6960

tgggcactgc tgtggagtct gcttctccca tgtaccaggg caccaggccc acccaactga     7020

aggcatggcg gcggggtgca ggggaaagtt aaaggtgatg acgatcatca cacctgtgtc     7080

gttacctcag ccatcggtct agcatatcag tcactgggcc caacatatcc atttttaaac     7140

cctttccccc aaatacactg cgtcctggtt cctgtttagc tgttctgaaa tacggtgtgt     7200

aagtaagtca gaacccagct accagtgatt attgcgaggg caatgggacc tcataaataa     7260

ggttttctgt gatgtgacgc cagtttacat aagagaatat cactccgatg gtcggtttct     7320

gactgtcacg ctaagggcaa ctgtaaactg gaataataat gcactcgcaa ccaggtaaac     7380

ttagatacac tagtttgttt aaaattatag atttactgta catgacttgt aatatactat     7440

aatttgtatt tgtaaagaga tggtctatat tttgtaatta ctgtattgta tttgaactgc     7500

agcaatatcc atgggtccta ataattgtag ttccccacta aaatctagaa attattagta     7560

tttttactcg ggctatccag aagtagaaga aatagagcca attctcattt attcagcgaa     7620

aatcctctgg ggttaaaatt ttaagtttga aagaacttga cactacagaa atttttctaa     7680

aatattttga gtcactataa acctatcatc tttccacaag ataaaa                    7726


<210>  31
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
1               5                   10                  15      


Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
            20                  25                  30          


Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
        35                  40                  45              


Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
    50                  55                  60                  


Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
65                  70                  75                  80  


Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                85                  90                  95      


Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
            100                 105                 110         


Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
        115                 120                 125             


Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
    130                 135                 140                 


Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
145                 150                 155                 160 


Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                165                 170                 175     


Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
            180                 185                 190         


Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
        195                 200                 205 


<210>  32
<211>  3055
<212>  DNA
<213>  Homo sapiens

<400>  32
actttcccga ggtgcttcta cagttccctc tgccagcagg ggaacagatg gaaatagcaa       60

tcacctgcca gaaggtggcg tgcagcaagg atgtgcatct tttgccgcta ctgctttctg      120

attcctaaaa attactcaga gatcactcat gtgttcagtg attcaggttc tgttgaagat      180

accaaagata ttcggttggt caaaatgacg ggcatataaa ggcttctcag gtttctgagt      240

gcaaaagata tgaaacatcg gctaggtttc ctgctgcaaa aatctgattc ctgtgaacac      300

aattcttccc acaacaagaa ggacaaagtg gttatttgcc agagagtgag ccaagaggaa      360

gtcaagaaat gggctgaatc actggaaaac ctgattagtc atgaatgtgg gctggcagct      420

ttcaaagctt tcttgaagtc tgaatatagt gaggagaata ttgacttctg gatcagctgt      480

gaagagtaca agaaaatcaa atcaccatct aaactaagtc ccaaggccaa aaagatctat      540

aatgaattca tctcagtcca ggcaaccaaa gaggtgaacc tggattcttg caccagggaa      600

gagacaagcc ggaacatgct agagcctaca ataacctgct ttgatgaggc ccagaagaag      660

attttcaacc tgatggagaa ggattcctac cgccgcttcc tcaagtctcg attctatctt      720

gatttggtca acccgtccag ctgtggggca gaaaagcaga aaggagccaa gagttcagca      780

gactgtgctt ccctggtccc tcagtgtgcc taattctcac ctgaaggcag agggatgaaa      840

tgccaagact ctatgctctg gaaaacctga ggccaaatat tgatctgtat taagctccag      900

tgctttatcc acattgtagc ctaatattca tgctgcctgc catgtgtgag tcacttctac      960

gcataaacta gatatagctt ttggtgtttg agtgttcatc agggtgggac cccattccag     1020

tccaattttc ctaagtttct ttgagggttc catgggagca aatatctaaa taatggcctg     1080

gtaggtctgg attttcaaag attgttggca gtttcctcct cccaacagtt ttacctcggg     1140

atggttggtt agtgcatgtc acatgacatc cacatgcaca tgtattctgt tggccagcac     1200

gttctccaga ctctagatgt ttagatgagg ttgagctatg atatgtgctt gtgtgtatgt     1260

ctatgtgtat atattatata tacattagac acacatatac attatttctg tatatagatg     1320

tctgtgtata catatgtatg tgtgagtgta tgtatacaca cacacacaca cacacacaca     1380

cacttttgca agagtgatgg gaaagaccct aggtgctcat aactagagta tgtgtatgta     1440

cttacatggg tgttttgatc tctgttcttt catactacat ttgaacaggg caaaatgaac     1500

taactgccat gtaggctaag aaagaaatgc taacctgtgg aaagttggtt ttgtaaaatt     1560

ccatggatct tgctggagaa gcatccaagg aacttcatgc ttgatttgac cactgacagc     1620

ctccaccttg agcactattc taaggagcaa ataccttagc tcccttgagc tggttttctc     1680

tgatggcact tttgagctcc taagctgcca gccttccctt cttttcctgg gtgctcaggg     1740

catgcttatt agcagctggg ttggtatgga gttggcagac aggatgttca acttaatgaa     1800

gaaatacagc taaggccttg ccagcaacac ctgccgtaag ttactggctg agtgagggca     1860

tagaagttaa aggttactgt ttttatcctc tatccttttt tcctttcctg atcaaggtgc     1920

tcttctcatt ttttcctgag aaccttagcc atcagatgag gctccttagt ttattgtggt     1980

tggttgtttt ttctttataa tggctctggg ctatatgcct atatttataa accagcagca     2040

ggggaaagat tatattttat aagagggaac aaattttcac aatttgaaaa gcccacataa     2100

gttttctctt ttaaggtaga atcttgttaa tttcattcca aacatcgggg ctaacagaga     2160

ctggaggcat ttctttttag gctctgagac taaatgagag gaaaagaaaa gaaaaaaaaa     2220

atgattgtct aaccaattgt gagaattact gtttgaaact tttcaaggca cattgaaata     2280

cttgaaaact tctcatttat gttatttatg atgttatttt gtacgtgtta ttattattat     2340

attgttttat aaatggaggt acaggatatc acctgaatta ttaatgaatg cccaggaagt     2400

aattttcttc tcattcttct aaaactactg cctttcaaag tgcacacaca cgcgtccaca     2460

tacactgcat tcgttgctcc agtataaatt acatgcatga gcacctttct ggcttttaag     2520

ccaatataat gggctgcaaa atgaagacac cagagtgtat gcatacaaat ctcactgtat     2580

taaagatgca ggttttctaa ttgtaccctt cttgtctctc tggcaatctt gcccttaata     2640

tccctggagt tcctcatcag tgtcattttc tgttatacac agttccacaa ttttgtctct     2700

agttgacttc aaatgtgtaa ctttattggt cttgccctat tataattgtc atgactttca     2760

gattgtatct gaactcacag actgctgtct tactaatagg tctggaaggt cacgctgaat     2820

gagaagtaaa ttattttatg taatacattt ttgagtgtgt ttttcagttg tatttccctg     2880

ttatttcatc actatttcca atggtgagct tgcctgctca tgctccctgg acagaatact     2940

ccttcctttt gcatgcctgt ttctatcatg tgcttgatag gcctcaaagc taatgcttcc     3000

agtgaaacac acgcatctta ataataaggg taaataaacg ctccatatga aacta          3055


<210>  33
<211>  313
<212>  PRT
<213>  Homo sapiens

<400>  33

Met Leu Leu Leu Ala Asp Met Asp Val Val Asn Gln Leu Val Ala Gly 
1               5                   10                  15      


Gly Gln Phe Arg Val Val Lys Glu Pro Leu Gly Phe Val Lys Val Leu 
            20                  25                  30          


Gln Trp Val Phe Ala Ile Phe Ala Phe Ala Thr Cys Gly Ser Tyr Ser 
        35                  40                  45              


Gly Glu Leu Gln Leu Ser Val Asp Cys Ala Asn Lys Thr Glu Ser Asp 
    50                  55                  60                  


Leu Ser Ile Glu Val Glu Phe Glu Tyr Pro Phe Arg Leu His Gln Val 
65                  70                  75                  80  


Tyr Phe Asp Ala Pro Thr Cys Arg Gly Gly Thr Thr Lys Val Phe Leu 
                85                  90                  95      


Val Gly Asp Tyr Ser Ser Ser Ala Glu Phe Phe Val Thr Val Ala Val 
            100                 105                 110         


Phe Ala Phe Leu Tyr Ser Met Gly Ala Leu Ala Thr Tyr Ile Phe Leu 
        115                 120                 125             


Gln Asn Lys Tyr Arg Glu Asn Asn Lys Gly Pro Met Leu Asp Phe Leu 
    130                 135                 140                 


Ala Thr Ala Val Phe Ala Phe Met Trp Leu Val Ser Ser Ser Ala Trp 
145                 150                 155                 160 


Ala Lys Gly Leu Ser Asp Val Lys Met Ala Thr Asp Pro Glu Asn Ile 
                165                 170                 175     


Ile Lys Glu Met Pro Val Cys Arg Gln Thr Gly Asn Thr Cys Lys Glu 
            180                 185                 190         


Leu Arg Asp Pro Val Thr Ser Gly Leu Asn Thr Ser Val Val Phe Gly 
        195                 200                 205             


Phe Leu Asn Leu Val Leu Trp Val Gly Asn Leu Trp Phe Val Phe Lys 
    210                 215                 220                 


Glu Thr Gly Trp Ala Ala Pro Phe Leu Arg Ala Pro Pro Gly Ala Pro 
225                 230                 235                 240 


Glu Lys Gln Pro Ala Pro Gly Asp Ala Tyr Gly Asp Ala Gly Tyr Gly 
                245                 250                 255     


Gln Gly Pro Gly Gly Tyr Gly Pro Gln Asp Ser Tyr Gly Pro Gln Gly 
            260                 265                 270         


Gly Tyr Gln Pro Asp Tyr Gly Gln Pro Ala Gly Ser Gly Gly Ser Gly 
        275                 280                 285             


Tyr Gly Pro Gln Gly Asp Tyr Gly Gln Gln Gly Tyr Gly Pro Gln Gly 
    290                 295                 300                 


Ala Pro Thr Ser Phe Ser Asn Gln Met 
305                 310             


<210>  34
<211>  2449
<212>  DNA
<213>  Homo sapiens

<400>  34
gccccctgca ttgctgatgc tgctgctggc ggacatggac gtggtgaatc agctggtggc       60

tgggggtcag ttccgggtgg tcaaggagcc cctcggcttt gtgaaggtgc tgcaatgggt      120

cttcgccatc ttcgcctttg ccacatgcgg cagctacagt ggggagctcc agctgagcgt      180

ggattgtgcc aacaagaccg agagtgacct cagcatcgag gtcgagttcg agtacccctt      240

caggctgcac caagtgtact ttgatgcacc cacctgccga gggggcacca ccaaggtctt      300

cttagttggg gactactcct cgtcagccga attctttgtc accgtggccg tgtttgcctt      360

cctctactcc atgggggctc tggccaccta catcttcctg cagaacaagt accgagagaa      420

taacaaaggg cccatgctgg actttctggc cacggctgtg ttcgccttca tgtggctagt      480

tagctcatcg gcatgggcca aggggctgtc agatgtgaag atggccacag acccagagaa      540

cattatcaag gagatgcctg tctgccgcca gacagggaac acatgcaagg agctgagaga      600

ccctgtgacc tcgggactca acacctcggt ggtgttcggc ttcctgaacc tggtgctctg      660

ggtcggcaac ctgtggttcg tgtttaagga gacaggctgg gccgccccgt tcctgcgcgc      720

gcctcccggc gcccccgaga aacaaccggc acccggggac gcctacggcg atgcaggcta      780

cgggcagggc cccggcgggt acgggcccca ggattcctac gggcctcagg gcggctacca      840

gcctgactat ggtcaaccag ccggcagcgg tggcagtggc tacgggcctc agggcgacta      900

tgggcagcaa ggctacggcc cgcagggtgc acccacctcc ttctccaatc agatgtagtc      960

tggtcagtga agcccaggag gacctggggg gggcaagagc tcaggagaag gcctgccccc     1020

cttcccaccc ctatacccta ggtctccacc cctcaagcca ggagaccctg tctttgctgt     1080

ttatatatat atatattata tataaatatc tatttatctg tctgagccct gccctcactc     1140

cactcccctc atccactagg tgcccagtct tgagtgggcc ccctctctta ccccgtccct     1200

ttccctgcat cccttggccc ctctctgttt accctccctg tcccctgagg ttaaggggat     1260

ctaaaaggag gacagggagg gaacagacct cggctgtgtg gggagggtgg gcgtgacttc     1320

agactctctc ctctctctcc ctccactcct cccaactctg gccttggttc ctccagcaat     1380

gcctgcctga acaaaggccg ttagggaaat ccaactccag ggttaaagaa aggcagagat     1440

tgggggggct tggggtagag aggacagttt aggacccaag gtggtcttgg agaggaggtg     1500

tggagtggag gggtcagcag gggggttggg ttccagacag agtggatctg gagtctgaag     1560

gagaggagtg cgctagagca ttctggggtg gggcttggaa gggcgctgag ggcagggttc     1620

tagaaggggc gaggctttaa gcgaggcaga atggtgggct ccagagtagg tgggtcttgg     1680

attggtacca gagcctatgg aaagggtgtg gcttggaaca tttgggagac tgagcttgat     1740

tctaaagggg acagatcttg agcaaggcaa gaagtgggat tcaggaatgg gccaagccag     1800

ggttccagac agggtggggc ttagaatggg gcttccatgg tggtttcaga aagggcagcc     1860

cctccccatg gtgcagtgaa gaaaatgttt tacaatggct gggtttgggc agtggagagg     1920

ggacttggat aggagcttcc agatgggttt tgttaggggt gggggagaat ggctctggct     1980

acgacttggg acggaagtgg cctgagaaga gtcgagtgat atggcttgta gggtgaggcg     2040

tgggatccag agagaagcac cccaccacac acacccttcc ccactcccgt gatgaaacag     2100

ctaggttaat aggaggacag aaccaacggg tctgtgggac tggcccaccc ctcttccccc     2160

ttcccctgcg ccctccctcc ctccacacct ccacccgtcc tggggtggtt ggaggcctgg     2220

tctggagccc ctatcctgca ccctctgcta tgtctgtgat gtcagtagtg cctgtgatcg     2280

tgtgttgcca ttttgtctgg ctgtggcccc tccttctccc ctccagaccc ctaccctttc     2340

ccaaaccctt cggtattgtt caaagaaccc ccctccccaa ggaagaacaa atatgattct     2400

cctctcccaa ataaactcct taaccaccta gtcaaaaaaa aaaaaaaaa                 2449


<210>  35
<211>  19
<212>  DNA
<213>  Homo sapiens

<400>  35
cagtagtttg gccatggga                                                    19


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Sythesized Primer

<400>  36
ctgacggtcc aaatccttgt                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  37
tgccagatac cagccaaagt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  38
ccagagagtg agccaagagg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Sequence

<400>  39
atctttttgg ccttgggact                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  40
catgtcctcc tgcatctcct                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  41
agccttgcaa gtgaatggaa                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  42
gcatcgagag gagttgaagc                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  43
gccctctggg tattttccat                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  44
attgctgcct acgtccactt                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  45
ttgggtgttt tgccaatgta                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  46
tccctgtgaa aacaagagca                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  47
atagagtcgc caccctgatg                                                   20


<210>  48
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  48
gatcttttcc accccaagag tacataa                                           27


<210>  49
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Chemically Synthesized Primer

<400>  49
ctcacacaaa cacagattcc acaac                                             25


<210>  50
<211>  471
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gln Ser Asn Lys Thr Phe Asn Leu Glu Lys Gln Asn His Thr Pro 
1               5                   10                  15      


Arg Lys His His Gln His His His Gln Gln Gln His His Gln Gln Gln 
            20                  25                  30          


Gln Gln Gln Pro Pro Pro Pro Pro Ile Pro Ala Asn Gly Gln Gln Ala 
        35                  40                  45              


Ser Ser Gln Asn Glu Gly Leu Thr Ile Asp Leu Lys Asn Phe Arg Lys 
    50                  55                  60                  


Pro Gly Glu Lys Thr Phe Thr Gln Arg Ser Arg Leu Phe Val Gly Asn 
65                  70                  75                  80  


Leu Pro Pro Asp Ile Thr Glu Glu Glu Met Arg Lys Leu Phe Glu Lys 
                85                  90                  95      


Tyr Gly Lys Ala Gly Glu Val Phe Ile His Lys Asp Lys Gly Phe Gly 
            100                 105                 110         


Phe Ile Arg Leu Glu Thr Arg Thr Leu Ala Glu Ile Ala Lys Val Glu 
        115                 120                 125             


Leu Asp Asn Met Pro Leu Arg Gly Lys Gln Leu Arg Val Arg Phe Ala 
    130                 135                 140                 


Cys His Ser Ala Ser Leu Thr Val Arg Asn Leu Pro Gln Tyr Val Ser 
145                 150                 155                 160 


Asn Glu Leu Leu Glu Glu Ala Phe Ser Val Phe Gly Gln Val Glu Arg 
                165                 170                 175     


Ala Val Val Ile Val Asp Asp Arg Gly Arg Pro Ser Gly Lys Gly Ile 
            180                 185                 190         


Val Glu Phe Ser Gly Lys Pro Ala Ala Arg Lys Ala Leu Asp Arg Cys 
        195                 200                 205             


Ser Glu Gly Ser Phe Leu Leu Thr Thr Phe Pro Arg Pro Val Thr Val 
    210                 215                 220                 


Glu Pro Met Asp Gln Leu Asp Asp Glu Glu Gly Leu Pro Glu Lys Leu 
225                 230                 235                 240 


Val Ile Lys Asn Gln Gln Phe His Lys Glu Arg Glu Gln Pro Pro Arg 
                245                 250                 255     


Phe Ala Gln Pro Gly Ser Phe Glu Tyr Glu Tyr Ala Met Arg Trp Lys 
            260                 265                 270         


Ala Leu Ile Glu Met Glu Lys Gln Gln Gln Asp Gln Val Asp Arg Asn 
        275                 280                 285             


Ile Lys Glu Ala Arg Glu Lys Leu Glu Met Glu Met Glu Ala Ala Arg 
    290                 295                 300                 


His Glu His Gln Val Met Leu Met Arg Gln Asp Leu Met Arg Arg Gln 
305                 310                 315                 320 


Glu Glu Leu Arg Arg Met Glu Glu Leu His Asn Gln Glu Val Gln Lys 
                325                 330                 335     


Arg Lys Gln Leu Glu Leu Arg Gln Glu Glu Glu Arg Arg Arg Arg Glu 
            340                 345                 350         


Glu Glu Met Arg Arg Gln Gln Glu Glu Met Met Arg Arg Gln Gln Glu 
        355                 360                 365             


Gly Phe Lys Gly Thr Phe Pro Asp Ala Arg Glu Gln Glu Ile Arg Met 
    370                 375                 380                 


Gly Gln Met Ala Met Gly Gly Ala Met Gly Ile Asn Asn Arg Gly Ala 
385                 390                 395                 400 


Met Pro Pro Ala Pro Val Pro Ala Gly Thr Pro Ala Pro Pro Gly Pro 
                405                 410                 415     


Ala Thr Met Met Pro Asp Gly Thr Leu Gly Leu Thr Pro Pro Thr Thr 
            420                 425                 430         


Glu Arg Phe Gly Gln Ala Ala Thr Met Glu Gly Ile Gly Ala Ile Gly 
        435                 440                 445             


Gly Thr Pro Pro Ala Phe Asn Arg Ala Ala Pro Gly Ala Glu Phe Ala 
    450                 455                 460                 


Pro Asn Lys Arg Arg Arg Tyr 
465                 470     


