                         SEQUENCE LISTING

<110>  The Trustees Of The University Of Pennsylvania
       Albelda, Steven A
       Pure, Ellen
       Todd, Leslie
 
<120>  DISRUPTING TUMOR TISSUES BY TARGETING FIBROBLAST ACTIVATION 
       PROTEIN (FAP)

<130>  046483-7273WO1(02349)

<150>  62/904,340
<151>  2019-09-23

<160>  55    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR1

<400>  1

Tyr Thr Ile Thr Ser Tyr Ser Leu His 
1               5                   


<210>  2
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR2

<400>  2

Glu Ile Asn Pro Ala Asn Gly Asp His Asn Phe Ser Glu Lys Phe Glu 
1               5                   10                  15      


Ile Lys 
        


<210>  3
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR3

<400>  3

Leu Asp Asp Ser Arg Phe His Trp Tyr Phe Asp Val 
1               5                   10          


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 LCDR1

<400>  4

Thr Ala Ser Ser Ser Val Ser Tyr Met Tyr 
1               5                   10  


<210>  5
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 LCDR2

<400>  5

Leu Thr Ser Asn Leu Ala 
1               5       


<210>  6
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 LCDR3

<400>  6

Gln Gln Trp Ser Gly Tyr Pro Pro Ile Thr 
1               5                   10  


<210>  7
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 VH

<400>  7

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Ser Tyr 
            20                  25                  30          


Ser Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ala Asn Gly Asp His Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Glu Ile Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Asp Asp Ser Arg Phe His Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser 
        115                 120     


<210>  8
<211>  363
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5 VH

<400>  8
caggtccaac tgcagcagcc tggggctgaa ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cgtctggcta caccatcacc agctactctc tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attaatcctg ccaatggtga tcataacttc      180

agtgagaagt tcgagatcaa ggccacactg actgtagaca gctcctccaa cacagcattc      240

atgcaactca gcaggctgac atctgaggac tctgcggtct attactgtac aagattggac      300

gatagtaggt tccactggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tca                                                                    363


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 VL

<400>  9

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Phe 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Arg 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  10
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5 VL

<400>  10
caaattgttc tcacccagtc tccagcgctc atgtctgctt ctccagggga gaaggtcacc       60

atgacctgca ctgccagctc aagtgttagt tacatgtact ggtaccagca gaagccacga      120

tcctccccca aaccctggat ttttctcacc tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggcc gtgggtctgg gacctctttc tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtggttacc cacccatcac attcggctcg      300

gggacaaagt tggaaataaa a                                                321


<210>  11
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 scFv VLVH

<400>  11

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Phe 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Arg 
    50                  55                  60                  


Gly Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Pro Ile 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Gln Gln 
        115                 120                 125             


Pro Gly Ala Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys 
    130                 135                 140                 


Lys Ala Ser Gly Tyr Thr Ile Thr Ser Tyr Ser Leu His Trp Val Lys 
145                 150                 155                 160 


Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Ala 
                165                 170                 175     


Asn Gly Asp His Asn Phe Ser Glu Lys Phe Glu Ile Lys Ala Thr Leu 
            180                 185                 190         


Thr Val Asp Ser Ser Ser Asn Thr Ala Phe Met Gln Leu Ser Arg Leu 
        195                 200                 205             


Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Asp Asp Ser 
    210                 215                 220                 


Arg Phe His Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr 
225                 230                 235                 240 


Val Ser Ser 
            


<210>  12
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5 scFv VLVH

<400>  12
caaattgttc tcacccagtc tccagcgctc atgtctgctt ctccagggga gaaggtcacc       60

atgacctgca ctgccagctc aagtgttagt tacatgtact ggtaccagca gaagccacga      120

tcctccccca aaccctggat ttttctcacc tccaacctgg cttctggagt ccctgctcgc      180

ttcagtggcc gtgggtctgg gacctctttc tctctcacaa tcagcagcat ggaggctgaa      240

gatgctgcca cttattactg ccagcagtgg agtggttacc cacccatcac attcggctcg      300

gggacaaagt tggaaataaa aggtggaggt ggcagcggag gaggtgggtc cggcggtgga      360

ggaagccagg tccaactgca gcagcctggg gctgaactgg taaagcctgg ggcttcagtg      420

aagttgtcct gcaaggcgtc tggctacacc atcaccagct actctctgca ctgggtgaag      480

cagaggcctg gacaaggcct tgagtggatt ggagagatta atcctgccaa tggtgatcat      540

aacttcagtg agaagttcga gatcaaggcc acactgactg tagacagctc ctccaacaca      600

gcattcatgc aactcagcag gctgacatct gaggactctg cggtctatta ctgtacaaga      660

ttggacgata gtaggttcca ctggtacttc gatgtctggg gcgcagggac cacggtcacc      720

gtctcctca                                                              729


<210>  13
<211>  243
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 scFv VHVL

<400>  13

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Ser Tyr 
            20                  25                  30          


Ser Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ala Asn Gly Asp His Asn Phe Ser Glu Lys Phe 
    50                  55                  60                  


Glu Ile Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala Phe 
65                  70                  75                  80  


Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Leu Asp Asp Ser Arg Phe His Trp Tyr Phe Asp Val Trp Gly 
            100                 105                 110         


Ala Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Val Leu Thr Gln Ser Pro 
    130                 135                 140                 


Ala Leu Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Thr 
145                 150                 155                 160 


Ala Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg 
                165                 170                 175     


Ser Ser Pro Lys Pro Trp Ile Phe Leu Thr Ser Asn Leu Ala Ser Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Arg Gly Ser Gly Thr Ser Phe Ser Leu 
        195                 200                 205             


Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Trp Ser Gly Tyr Pro Pro Ile Thr Phe Gly Ser Gly Thr Lys Leu 
225                 230                 235                 240 


Glu Ile Lys 
            


<210>  14
<211>  729
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5 scFv VHVL

<400>  14
caggtccaac tgcagcagcc tggggctgaa ctggtaaagc ctggggcttc agtgaagttg       60

tcctgcaagg cgtctggcta caccatcacc agctactctc tgcactgggt gaagcagagg      120

cctggacaag gccttgagtg gattggagag attaatcctg ccaatggtga tcataacttc      180

agtgagaagt tcgagatcaa ggccacactg actgtagaca gctcctccaa cacagcattc      240

atgcaactca gcaggctgac atctgaggac tctgcggtct attactgtac aagattggac      300

gatagtaggt tccactggta cttcgatgtc tggggcgcag ggaccacggt caccgtctcc      360

tcaggtggag gtggcagcgg aggaggtggg tccggcggtg gaggaagcca aattgttctc      420

acccagtctc cagcgctcat gtctgcttct ccaggggaga aggtcaccat gacctgcact      480

gccagctcaa gtgttagtta catgtactgg taccagcaga agccacgatc ctcccccaaa      540

ccctggattt ttctcacctc caacctggct tctggagtcc ctgctcgctt cagtggccgt      600

gggtctggga cctctttctc tctcacaatc agcagcatgg aggctgaaga tgctgccact      660

tattactgcc agcagtggag tggttaccca cccatcacat tcggctcggg gacaaagttg      720

gaaataaaa                                                              729


<210>  15
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 alpha hinge

<400>  16

Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala 
1               5                   10                  15      


Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly 
            20                  25                  30          


Gly Ala Val His Thr Arg Gly Leu Asp Phe Ala Cys Asp 
        35                  40                  45  


<210>  17
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD8 transmembrane domain

<400>  17

Ile Tyr Ile Trp Ala Pro Leu Ala Gly Thr Cys Gly Val Leu Leu Leu 
1               5                   10                  15      


Ser Leu Val Ile Thr Leu Tyr 
            20              


<210>  18
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  41BB ICD

<400>  18

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu 
        35                  40      


<210>  19
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD28 ICD

<400>  19

Arg Ser Lys Arg Ser Arg Leu Leu His Ser Asp Tyr Met Asn Met Thr 
1               5                   10                  15      


Pro Arg Arg Pro Gly Pro Thr Arg Lys His Tyr Gln Pro Tyr Ala Pro 
            20                  25                  30          


Pro Arg Asp Phe Ala Ala Tyr Arg Ser 
        35                  40      


<210>  20
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DAP12 ICD

<400>  20

Glu Arg Trp Cys Ser Asn Lys Lys Asn Ala Ala Val Met Asp Gln Glu 
1               5                   10                  15      


Pro Ala Gly Asn Arg Thr Val Asn Ser Glu Asp Ser Asp Glu Gln Asp 
            20                  25                  30          


His Gln Glu Val Ser Tyr Ala 
        35                  


<210>  21
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD3 zeta ICD

<400>  21

Arg Val Lys Phe Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly 
1               5                   10                  15      


Gln Asn Gln Leu Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr 
            20                  25                  30          


Asp Val Leu Asp Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys 
        35                  40                  45              


Pro Arg Arg Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys 
    50                  55                  60                  


Asp Lys Met Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg 
65                  70                  75                  80  


Arg Arg Gly Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala 
                85                  90                  95      


Thr Lys Asp Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
            100                 105                 110         


<210>  22
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5HG2LCD8HBBCD3Z CAR

<400>  22
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc aggtccaact gcagcagcct ggggctgaac tggtaaagcc tggggcttca      120

gtgaagttgt cctgcaaggc gtctggctac accatcacca gctactctct gcactgggtg      180

aagcagaggc ctggacaagg ccttgagtgg attggagaga ttaatcctgc caatggtgat      240

cataacttca gtgagaagtt cgagatcaag gccacactga ctgtagacag ctcctccaac      300

acagcattca tgcaactcag caggctgaca tctgaggact ctgcggtcta ttactgtaca      360

agattggacg atagtaggtt ccactggtac ttcgatgtct ggggcgcagg gaccacggtc      420

accgtctcct caggtggagg tggcagcgga ggaggtgggt ccggcggtgg aggaagccaa      480

attgttctca cccagtctcc agcgctcatg tctgcttctc caggggagaa ggtcaccatg      540

acctgcactg ccagctcaag tgttagttac atgtactggt accagcagaa gccacgatcc      600

tcccccaaac cctggatttt tctcacctcc aacctggctt ctggagtccc tgctcgcttc      660

agtggccgtg ggtctgggac ctctttctct ctcacaatca gcagcatgga ggctgaagat      720

gctgccactt attactgcca gcagtggagt ggttacccac ccatcacatt cggctcgggg      780

acaaagttgg aaataaaatc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg      840

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      900

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctaa                               1476


<210>  23
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5HG2LCD8HBBCD3Z CAR

<400>  23

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Val Gln Leu Gln Gln Pro Gly Ala 
            20                  25                  30          


Glu Leu Val Lys Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser 
        35                  40                  45              


Gly Tyr Thr Ile Thr Ser Tyr Ser Leu His Trp Val Lys Gln Arg Pro 
    50                  55                  60                  


Gly Gln Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Ala Asn Gly Asp 
65                  70                  75                  80  


His Asn Phe Ser Glu Lys Phe Glu Ile Lys Ala Thr Leu Thr Val Asp 
                85                  90                  95      


Ser Ser Ser Asn Thr Ala Phe Met Gln Leu Ser Arg Leu Thr Ser Glu 
            100                 105                 110         


Asp Ser Ala Val Tyr Tyr Cys Thr Arg Leu Asp Asp Ser Arg Phe His 
        115                 120                 125             


Trp Tyr Phe Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
145                 150                 155                 160 


Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly Glu 
                165                 170                 175     


Lys Val Thr Met Thr Cys Thr Ala Ser Ser Ser Val Ser Tyr Met Tyr 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Trp Ile Phe Leu 
        195                 200                 205             


Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Arg Gly 
    210                 215                 220                 


Ser Gly Thr Ser Phe Ser Leu Thr Ile Ser Ser Met Glu Ala Glu Asp 
225                 230                 235                 240 


Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Gly Tyr Pro Pro Ile Thr 
                245                 250                 255     


Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  24
<211>  1476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  4G5L2HGCD8HBBCD3Z CAR

<400>  24
atggccctgc ctgtgacagc cctgctgctg cctctggctc tgctgctgca tgccgctaga       60

cccggatccc aaattgttct cacccagtct ccagcgctca tgtctgcttc tccaggggag      120

aaggtcacca tgacctgcac tgccagctca agtgttagtt acatgtactg gtaccagcag      180

aagccacgat cctcccccaa accctggatt tttctcacct ccaacctggc ttctggagtc      240

cctgctcgct tcagtggccg tgggtctggg acctctttct ctctcacaat cagcagcatg      300

gaggctgaag atgctgccac ttattactgc cagcagtgga gtggttaccc acccatcaca      360

ttcggctcgg ggacaaagtt ggaaataaaa ggtggaggtg gcagcggagg aggtgggtcc      420

ggcggtggag gaagccaggt ccaactgcag cagcctgggg ctgaactggt aaagcctggg      480

gcttcagtga agttgtcctg caaggcgtct ggctacacca tcaccagcta ctctctgcac      540

tgggtgaagc agaggcctgg acaaggcctt gagtggattg gagagattaa tcctgccaat      600

ggtgatcata acttcagtga gaagttcgag atcaaggcca cactgactgt agacagctcc      660

tccaacacag cattcatgca actcagcagg ctgacatctg aggactctgc ggtctattac      720

tgtacaagat tggacgatag taggttccac tggtacttcg atgtctgggg cgcagggacc      780

acggtcaccg tctcctcatc cggaaccacg acgccagcgc cgcgaccacc aacaccggcg      840

cccaccatcg cgtcgcagcc cctgtccctg cgcccagagg cgtgccggcc agcggcgggg      900

ggcgcagtgc acacgagggg gctggacttc gcctgtgata tctacatctg ggcgcccttg      960

gccgggactt gtggggtcct tctcctgtca ctggttatca ccctttactg caaacggggc     1020

agaaagaaac tcctgtatat attcaaacaa ccatttatga gaccagtaca aactactcaa     1080

gaggaagatg gctgtagctg ccgatttcca gaagaagaag aaggaggatg tgaactgaga     1140

gtgaagttca gcaggagcgc agacgccccc gcgtacaagc agggccagaa ccagctctat     1200

aacgagctca atctaggacg aagagaggag tacgatgttt tggacaagag acgtggccgg     1260

gaccctgaga tggggggaaa gccgagaagg aagaaccctc aggaaggcct gtacaatgaa     1320

ctgcagaaag ataagatggc ggaggcctac agtgagattg ggatgaaagg cgagcgccgg     1380

aggggcaagg ggcacgatgg cctttaccag ggtctcagta cagccaccaa ggacacctac     1440

gacgcccttc acatgcaggc cctgccccct cgctaa                               1476


<210>  25
<211>  491
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5L2HGCD8HBBCD3Z CAR

<400>  25

Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Gly Ser Gln Ile Val Leu Thr Gln Ser Pro Ala 
            20                  25                  30          


Leu Met Ser Ala Ser Pro Gly Glu Lys Val Thr Met Thr Cys Thr Ala 
        35                  40                  45              


Ser Ser Ser Val Ser Tyr Met Tyr Trp Tyr Gln Gln Lys Pro Arg Ser 
    50                  55                  60                  


Ser Pro Lys Pro Trp Ile Phe Leu Thr Ser Asn Leu Ala Ser Gly Val 
65                  70                  75                  80  


Pro Ala Arg Phe Ser Gly Arg Gly Ser Gly Thr Ser Phe Ser Leu Thr 
                85                  90                  95      


Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys Gln Gln 
            100                 105                 110         


Trp Ser Gly Tyr Pro Pro Ile Thr Phe Gly Ser Gly Thr Lys Leu Glu 
        115                 120                 125             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    130                 135                 140                 


Ser Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly 
145                 150                 155                 160 


Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Ile Thr Ser 
                165                 170                 175     


Tyr Ser Leu His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp 
            180                 185                 190         


Ile Gly Glu Ile Asn Pro Ala Asn Gly Asp His Asn Phe Ser Glu Lys 
        195                 200                 205             


Phe Glu Ile Lys Ala Thr Leu Thr Val Asp Ser Ser Ser Asn Thr Ala 
    210                 215                 220                 


Phe Met Gln Leu Ser Arg Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr 
225                 230                 235                 240 


Cys Thr Arg Leu Asp Asp Ser Arg Phe His Trp Tyr Phe Asp Val Trp 
                245                 250                 255     


Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ser Gly Thr Thr Thr Pro 
            260                 265                 270         


Ala Pro Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu 
        275                 280                 285             


Ser Leu Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His 
    290                 295                 300                 


Thr Arg Gly Leu Asp Phe Ala Cys Asp Ile Tyr Ile Trp Ala Pro Leu 
305                 310                 315                 320 


Ala Gly Thr Cys Gly Val Leu Leu Leu Ser Leu Val Ile Thr Leu Tyr 
                325                 330                 335     


Cys Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe 
            340                 345                 350         


Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg 
        355                 360                 365             


Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser 
    370                 375                 380                 


Arg Ser Ala Asp Ala Pro Ala Tyr Lys Gln Gly Gln Asn Gln Leu Tyr 
385                 390                 395                 400 


Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys 
                405                 410                 415     


Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Arg Arg Lys Asn 
            420                 425                 430         


Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu 
        435                 440                 445             


Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly 
    450                 455                 460                 


His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr 
465                 470                 475                 480 


Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490     


<210>  26
<211>  2283
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Full Length Canine FAP

<400>  26
atgaagacgt ggttaaaaat tgtatttgga gttgccacct ctgctgtgct tgctttattg       60

gtgatgtgca ttgtcttacg tccttcaaga gttcatgact ccgaaggagg tacaacaaga      120

gcactcacac tggaggatat tttaaatggg acatttacct ataaaacatt ttttccaaac      180

tggatttcag gacaagaata tcttcatcag tctacagata atgatatagt atattacaat      240

attgaaacag gagaatcata taccattttg agtaatgcca ccatgaaaag tgtgaatgct      300

tcaaattatg gcttatcacc tgatcgtcaa tttgcatatc tagaaagtga ttattcaaag      360

ctttggagat actcttacac tgcaacatat cacatctata acctcaataa tggagagttt      420

ataagaagaa atgagcttcc tcgtccaatt cagtatttat gctggtcgcc tgttgggagt      480

aaattagcat atgtctatca aaacaatatc tatttgaaac aaagaccaga agacccacct      540

tttcaaataa catataatgg aagagaaaat aaaatattca atggaatccc agactgggta      600

tatgaagagg aaatgcttgc tacaaaacat gctctctggt ggtctcctaa tggaaaattt      660

ttggcatatg cagaatttaa tgatacagag ataccagtta ttgcctattc ctattatggt      720

gatgaacaat atcctagaac aataaatatt ccatacccaa aggctggagc taagaaccct      780

gttgttcgga tctttattat cgataccact tatcctcagc agacaggtcc cagagaagtg      840

ccagttccag caatgatagc atcaagtgat tattatttca gttggctcac atgggttact      900

gatgaacgag tatgtttgca gtggctaaaa agaatccaga acgtttcagt tctgtccata      960

tgtgatttca gggaaggctg gcagacatgg gattgtccaa aggcccagga acatatagaa     1020

gaaagcagaa ctggatgggc tggtggattc tttgtttcaa caccagtttt cagctatgat     1080

gccatttcat actacaaaat atttagcgac aaggatggct acaaacatat tcactatatc     1140

aaagacactg tggaaaatgc tattcaaatt acaagtggca agtgggaggc cataaatata     1200

ttcagagtaa cacaggattc actgttttat tctagcaatg aatttgaaga ctacccagga     1260

agaagaaata tctatagaat tagcattgga agctctcctc caagcaaaaa gtgcattact     1320

tgccatctaa ggaaagaaag gtgccaatat tacacagcaa gtttcagtga ctacgccaag     1380

tactatgcac ttatctgcta tggcccaggc ctccccattt ccacccttca tgacggccac     1440

actgatcaag aaattaaaat cctggaagaa aacaaagaat tggaaaatgc tttgaaaaat     1500

atccagctgc ctaaagagga aattaagaaa cttgaagtgg atgatattac tttatggtac     1560

aagatgatgc ttcctccccg gtttgacaga tcaaagaagt atcccttgct aattcaagtg     1620

tatggtggtc cctgcagtca gagcgtaaag tctgtattca gtattaattg gatttcttat     1680

cttgcaagta aggaagggat agtcattgcc ttggtggatg gccgaggaac agcttaccaa     1740

ggtgacaaac tcctgtatgc agtatatcga aagctgggtg tttatgaagt tgaggaccag     1800

atcacagccg tcagaaaatt catagaaatg ggtttcattg atgaaaaaag aatagccata     1860

tggggctggt cctatggagg ctatgtttca tcactggccc ttgcttcagg aactggtctt     1920

ttcaaatgtg ggatagcagt ggctcctgtc tccagctggg aatattacgc atctatctac     1980

acagaacgat tcatgggcct cccaacaaag aacgataatc tcgagcacta caaaaattca     2040

actgtgatgg caagagcaga atatttcaga aatgtagact atcttctcat ccacggaaca     2100

gcagatgata atgtgcactt tcaaaactca gcacagattg ctaaagctct ggttaatgca     2160

caagtggatt tccaggcaat gtggtactct gaccagaacc atggcatacc cggcctgtcc     2220

tcgaagcact tatatacccg catgacccac ttcctaaagc agtgtttttc tttgtccgac     2280

tga                                                                   2283


<210>  27
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR1

<400>  27

Gly Tyr Thr Ile Thr Ser Tyr Ser Leu His 
1               5                   10  


<210>  28
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR2

<400>  28

Glu Ile Asn Pro Ala Asn Gly Asp His Asn Phe Ser Glu Lys Phe Glu 
1               5                   10                  15      


Ile Lys Ala Thr 
            20  


<210>  29
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 HCDR3

<400>  29

Thr Arg Leu Asp Asp Ser Arg Phe His Trp Tyr Phe Asp Val 
1               5                   10                  


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  4G5 LCDR2

<400>  30

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  31
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  31

Gly Ser Gly Gly Ser 
1               5   


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(4)
<223>  repeat n times, where n represents an integer of at least 1

<400>  32

Gly Gly Gly Ser 
1               


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker


<220>
<221>  REPEAT
<222>  (1)..(5)
<223>  repeat n times, where n represents an integer of at least 1

<400>  33

Gly Gly Gly Gly Ser 
1               5   


<210>  34
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  34

Gly Gly Ser Gly 
1               


<210>  35
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  35

Gly Gly Ser Gly Gly 
1               5   


<210>  36
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  36

Gly Ser Gly Ser Gly 
1               5   


<210>  37
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  37

Gly Ser Gly Gly Gly 
1               5   


<210>  38
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  38

Gly Gly Gly Ser Gly 
1               5   


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  39

Gly Ser Ser Ser Gly 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  40

Gly Gly Gly Gly Ser 
1               5   


<210>  41
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Linker

<400>  41
ggtggcggtg gctcgggcgg tggtgggtcg ggtggcggcg gatct                       45


<210>  42
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  42

Asp Lys Thr His Thr 
1               5   


<210>  43
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  43

Cys Pro Pro Cys 
1               


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  44

Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 
1               5                   10                  15  


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  45

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  46
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  46

Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
1               5                   10  


<210>  47
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  47

Lys Cys Cys Val Asp Cys Pro 
1               5           


<210>  48
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  48

Lys Tyr Gly Pro Pro Cys Pro 
1               5           


<210>  49
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  49

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  50

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  51

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  52
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  52

Ser Pro Asn Met Val Pro His Ala His His Ala Gln 
1               5                   10          


<210>  53
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge

<400>  53

Glu Pro Lys Ser Cys Asp Lys Thr Tyr Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  54
<211>  22
<212>  DNA
<213>  Primer

<400>  54
atgtagacgt ggttaaaaat tg                                                22


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  55
cgtcatcttc agtcggacaa                                                   20


