                         SEQUENCE LISTING

<110>  Symrise AG
 
<120>  Methods for the biocatalytical manufacturing of dihydrochalcones

<130>  SM 6253-02WO

<150>  PCT/EP2019/076265
<151>  2019-09-27

<160>  76    

<170>  PatentIn version 3.5

<210>  1
<211>  476
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  1
tttttgtaga aatgtcttgg tgtcctcgac caatcaggta gccatccctg aaatacctgg       60

ctccgtggca acaccgaacg acctgctggc aacgttaaat tctccggggt aaaacttaaa      120

tgtggagtaa tagaaccaga aacgtctctt cccttctctc tccttccacc gcccgttacc      180

gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgct      240

cttcccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg      300

atggaaagtc ccggccgtcg ctggcaataa ctgcgggcgg acgcatgtct tgagattatt      360

ggaaaccacc agaatcgaat ataaaaggcg aacacctttc ccaattttgg tttctcctga      420

cccaaagact ttaaatttaa tttatttgtc cctatttcaa tcaattgaac aactat          476


<210>  2
<211>  477
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  2
tttttgtaga aatgtcttgg tgtcctcgtc caatcaggta gccatctctg aaatatctgg       60

ctccgttgca actccgaacg acctgctggc aacgtaaaat tctccggggt aaaacttaaa      120

tgtggagtaa tggaaccaga aacgtctctt cccttctctc tccttccacc gcccgttacc      180

gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgct      240

cttcccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg      300

atggaaaagt cccggccgtc gctggcaata atagcgggcg gacgcatgtc atgagattat      360

tggaaaccac cagaatcgaa tataaaaggc gaacaccttt cccaattttg gtttctcctg      420

acccaaagac tttaaattta atttatttgt ccctatttca atcaattgaa caactat         477


<210>  3
<211>  375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  3
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc       60

gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt      120

gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac      180

aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag      240

gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag      300

ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc      360

gaggagcagg actga                                                       375


<210>  4
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  4

Met Ala Lys Leu Thr Ser Ala Val Pro Val Leu Thr Ala Arg Asp Val 
1               5                   10                  15      


Ala Gly Ala Val Glu Phe Trp Thr Asp Arg Leu Gly Phe Ser Arg Asp 
            20                  25                  30          


Phe Val Glu Asp Asp Phe Ala Gly Val Val Arg Asp Asp Val Thr Leu 
        35                  40                  45              


Phe Ile Ser Ala Val Gln Asp Gln Val Val Pro Asp Asn Thr Leu Ala 
    50                  55                  60                  


Trp Val Trp Val Arg Gly Leu Asp Glu Leu Tyr Ala Glu Trp Ser Glu 
65                  70                  75                  80  


Val Val Ser Thr Asn Phe Arg Asp Ala Ser Gly Pro Ala Met Thr Glu 
                85                  90                  95      


Ile Gly Glu Gln Pro Trp Gly Arg Glu Phe Ala Leu Arg Asp Pro Ala 
            100                 105                 110         


Gly Asn Cys Val His Phe Val Ala Glu Glu Gln Asp 
        115                 120                 


<210>  5
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  5
atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct       60

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca      120

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc      180

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc      240

cgtgttgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg      300

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta      360

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc      420

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt      480

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg      540

cctgcagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct      600

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc      660

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct      720

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac      780

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc      840

tcactgatta agcattggta a                                                861


<210>  6
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  6

Met Ser His Ile Gln Arg Glu Thr Ser Cys Ser Arg Pro Arg Leu Asn 
1               5                   10                  15      


Ser Asn Met Asp Ala Asp Leu Tyr Gly Tyr Lys Trp Ala Arg Asp Asn 
            20                  25                  30          


Val Gly Gln Ser Gly Ala Thr Ile Tyr Arg Leu Tyr Gly Lys Pro Asp 
        35                  40                  45              


Ala Pro Glu Leu Phe Leu Lys His Gly Lys Gly Ser Val Ala Asn Asp 
    50                  55                  60                  


Val Thr Asp Glu Met Val Arg Leu Asn Trp Leu Thr Glu Phe Met Pro 
65                  70                  75                  80  


Leu Pro Thr Ile Lys His Phe Ile Arg Thr Pro Asp Asp Ala Trp Leu 
                85                  90                  95      


Leu Thr Thr Ala Ile Pro Gly Lys Thr Ala Phe Gln Val Leu Glu Glu 
            100                 105                 110         


Tyr Pro Asp Ser Gly Glu Asn Ile Val Asp Ala Leu Ala Val Phe Leu 
        115                 120                 125             


Arg Arg Leu His Ser Ile Pro Val Cys Asn Cys Pro Phe Asn Ser Asp 
    130                 135                 140                 


Arg Val Phe Arg Leu Ala Gln Ala Gln Ser Arg Met Asn Asn Gly Leu 
145                 150                 155                 160 


Val Asp Ala Ser Asp Phe Asp Asp Glu Arg Asn Gly Trp Pro Val Glu 
                165                 170                 175     


Gln Val Trp Lys Glu Met His Lys Leu Leu Pro Phe Ser Pro Asp Ser 
            180                 185                 190         


Val Val Thr His Gly Asp Phe Ser Leu Asp Asn Leu Ile Phe Asp Glu 
        195                 200                 205             


Gly Lys Leu Ile Gly Cys Ile Asp Val Gly Arg Val Gly Ile Ala Asp 
    210                 215                 220                 


Arg Tyr Gln Asp Leu Ala Ile Leu Trp Asn Cys Leu Gly Glu Phe Ser 
225                 230                 235                 240 


Pro Ser Leu Gln Lys Arg Leu Phe Gln Lys Tyr Gly Ile Asp Asn Pro 
                245                 250                 255     


Asp Met Asn Lys Leu Gln Phe His Leu Met Leu Asp Glu Phe Phe 
            260                 265                 270     


<210>  7
<211>  2079
<212>  DNA
<213>  Arabidopsis thaliana

<400>  7
atgaccagcg ccctgtatgc aagtgatctg tttaagcaac tgaaaagcat tatgggcacc       60

gatagtctga gtgatgatgt tgttctggtt attgccacca ccagtctggc cctggttgca      120

ggttttgtgg ttctgctgtg gaaaaagact accgccgatc gcagtggtga actgaaaccg      180

ctgatgattc cgaaaagcct gatggccaaa gatgaagatg atgatctgga tctgggcagc      240

ggtaaaaccc gtgttagcat tttctttggc acccagaccg gcaccgccga aggctttgcc      300

aaagcactga gcgaagaaat taaggcccgc tatgaaaaag cagcagttaa agtgattgat      360

ctggatgatt atgccgccga tgatgatcag tatgaagaaa aactgaaaaa ggaaaccctg      420

gcatttttct gtgtggcaac ctatggcgat ggtgaaccga ccgataatgc agcacgtttt      480

tataaatggt ttaccgaaga aaacgagcgt gatattaagc tgcaacagct ggcctatggc      540

gtttttgcac tgggtaatcg tcagtatgaa cattttaata agatcggcat tgtgctggat      600

gaagaactgt gtaaaaaagg cgcaaaacgt ctgattgaag tgggcctggg cgatgatgat      660

caaagtattg aagatgattt caacgcatgg aaagaaagcc tgtggagtga actggataaa      720

ctgctgaaag atgaagacga taaaagcgtt gcaaccccgt ataccgccgt tattccggaa      780

tatcgcgtgg tgacccatga tccgcgcttt accacccaga aaagtatgga aagtaatgtt      840

gccaatggta ataccaccat tgatattcat catccgtgtc gcgtggatgt ggccgttcag      900

aaagaactgc atacccatga aagcgatcgt agctgtattc atctggaatt tgatattagt      960

cgtaccggta ttacctatga aaccggtgac catgttggcg tttatgccga aaatcatgtt     1020

gaaattgtgg aagaagcagg taaactgctg ggccatagtc tggatctggt ttttagtatt     1080

catgcagata aagaagacgg tagtccgctg gaaagcgccg ttccgccgcc gtttccgggt     1140

ccttgcaccc tgggtacagg cctggcacgc tatgccgatc tgctgaatcc gccgcgtaaa     1200

agcgcactgg ttgccctggc cgcctatgca accgaaccga gcgaagcaga aaaactgaag     1260

catctgacca gcccggatgg taaagatgaa tatagccagt ggattgttgc aagccagcgt     1320

agcctgctgg aagttatggc cgcctttccg agtgcaaaac cgccgctggg tgttttcttt     1380

gccgcaatcg ctccgcgtct gcaaccgcgc tattatagca ttagcagtag tccgcgtctg     1440

gcaccgagcc gcgtgcatgt taccagtgca ctggtttatg gcccgacccc gaccggccgt     1500

attcataaag gtgtgtgtag cacctggatg aaaaatgcag ttccggccga aaaaagtcat     1560

gaatgtagtg gcgccccgat ttttattcgc gccagcaatt ttaaactgcc gagtaatccg     1620

agcaccccga ttgttatggt gggtccgggc accggtctgg caccgtttcg cggttttctg     1680

caagaacgca tggcactgaa agaagatggc gaagaactgg gcagtagtct gctgtttttc     1740

ggttgtcgta atcgccagat ggattttatc tatgaagatg aactgaacaa cttcgttgat     1800

cagggcgtga ttagcgaact gattatggcc tttagtcgtg aaggtgccca gaaagaatat     1860

gttcagcata aaatgatgga gaaagccgcc caggtttggg atctgattaa ggaagaaggc     1920

tatctgtatg tgtgtggcga tgcaaaaggc atggcacgtg atgttcatcg taccctgcat     1980

accattgttc aggaacagga aggtgtgagc agcagcgaag cagaggccat tgtgaaaaaa     2040

ctgcaaaccg aaggtcgtta tctgcgtgat gtgtggtaa                            2079


<210>  8
<211>  692
<212>  PRT
<213>  Arabidopsis thaliana

<400>  8

Met Thr Ser Ala Leu Tyr Ala Ser Asp Leu Phe Lys Gln Leu Lys Ser 
1               5                   10                  15      


Ile Met Gly Thr Asp Ser Leu Ser Asp Asp Val Val Leu Val Ile Ala 
            20                  25                  30          


Thr Thr Ser Leu Ala Leu Val Ala Gly Phe Val Val Leu Leu Trp Lys 
        35                  40                  45              


Lys Thr Thr Ala Asp Arg Ser Gly Glu Leu Lys Pro Leu Met Ile Pro 
    50                  55                  60                  


Lys Ser Leu Met Ala Lys Asp Glu Asp Asp Asp Leu Asp Leu Gly Ser 
65                  70                  75                  80  


Gly Lys Thr Arg Val Ser Ile Phe Phe Gly Thr Gln Thr Gly Thr Ala 
                85                  90                  95      


Glu Gly Phe Ala Lys Ala Leu Ser Glu Glu Ile Lys Ala Arg Tyr Glu 
            100                 105                 110         


Lys Ala Ala Val Lys Val Ile Asp Leu Asp Asp Tyr Ala Ala Asp Asp 
        115                 120                 125             


Asp Gln Tyr Glu Glu Lys Leu Lys Lys Glu Thr Leu Ala Phe Phe Cys 
    130                 135                 140                 


Val Ala Thr Tyr Gly Asp Gly Glu Pro Thr Asp Asn Ala Ala Arg Phe 
145                 150                 155                 160 


Tyr Lys Trp Phe Thr Glu Glu Asn Glu Arg Asp Ile Lys Leu Gln Gln 
                165                 170                 175     


Leu Ala Tyr Gly Val Phe Ala Leu Gly Asn Arg Gln Tyr Glu His Phe 
            180                 185                 190         


Asn Lys Ile Gly Ile Val Leu Asp Glu Glu Leu Cys Lys Lys Gly Ala 
        195                 200                 205             


Lys Arg Leu Ile Glu Val Gly Leu Gly Asp Asp Asp Gln Ser Ile Glu 
    210                 215                 220                 


Asp Asp Phe Asn Ala Trp Lys Glu Ser Leu Trp Ser Glu Leu Asp Lys 
225                 230                 235                 240 


Leu Leu Lys Asp Glu Asp Asp Lys Ser Val Ala Thr Pro Tyr Thr Ala 
                245                 250                 255     


Val Ile Pro Glu Tyr Arg Val Val Thr His Asp Pro Arg Phe Thr Thr 
            260                 265                 270         


Gln Lys Ser Met Glu Ser Asn Val Ala Asn Gly Asn Thr Thr Ile Asp 
        275                 280                 285             


Ile His His Pro Cys Arg Val Asp Val Ala Val Gln Lys Glu Leu His 
    290                 295                 300                 


Thr His Glu Ser Asp Arg Ser Cys Ile His Leu Glu Phe Asp Ile Ser 
305                 310                 315                 320 


Arg Thr Gly Ile Thr Tyr Glu Thr Gly Asp His Val Gly Val Tyr Ala 
                325                 330                 335     


Glu Asn His Val Glu Ile Val Glu Glu Ala Gly Lys Leu Leu Gly His 
            340                 345                 350         


Ser Leu Asp Leu Val Phe Ser Ile His Ala Asp Lys Glu Asp Gly Ser 
        355                 360                 365             


Pro Leu Glu Ser Ala Val Pro Pro Pro Phe Pro Gly Pro Cys Thr Leu 
    370                 375                 380                 


Gly Thr Gly Leu Ala Arg Tyr Ala Asp Leu Leu Asn Pro Pro Arg Lys 
385                 390                 395                 400 


Ser Ala Leu Val Ala Leu Ala Ala Tyr Ala Thr Glu Pro Ser Glu Ala 
                405                 410                 415     


Glu Lys Leu Lys His Leu Thr Ser Pro Asp Gly Lys Asp Glu Tyr Ser 
            420                 425                 430         


Gln Trp Ile Val Ala Ser Gln Arg Ser Leu Leu Glu Val Met Ala Ala 
        435                 440                 445             


Phe Pro Ser Ala Lys Pro Pro Leu Gly Val Phe Phe Ala Ala Ile Ala 
    450                 455                 460                 


Pro Arg Leu Gln Pro Arg Tyr Tyr Ser Ile Ser Ser Ser Pro Arg Leu 
465                 470                 475                 480 


Ala Pro Ser Arg Val His Val Thr Ser Ala Leu Val Tyr Gly Pro Thr 
                485                 490                 495     


Pro Thr Gly Arg Ile His Lys Gly Val Cys Ser Thr Trp Met Lys Asn 
            500                 505                 510         


Ala Val Pro Ala Glu Lys Ser His Glu Cys Ser Gly Ala Pro Ile Phe 
        515                 520                 525             


Ile Arg Ala Ser Asn Phe Lys Leu Pro Ser Asn Pro Ser Thr Pro Ile 
    530                 535                 540                 


Val Met Val Gly Pro Gly Thr Gly Leu Ala Pro Phe Arg Gly Phe Leu 
545                 550                 555                 560 


Gln Glu Arg Met Ala Leu Lys Glu Asp Gly Glu Glu Leu Gly Ser Ser 
                565                 570                 575     


Leu Leu Phe Phe Gly Cys Arg Asn Arg Gln Met Asp Phe Ile Tyr Glu 
            580                 585                 590         


Asp Glu Leu Asn Asn Phe Val Asp Gln Gly Val Ile Ser Glu Leu Ile 
        595                 600                 605             


Met Ala Phe Ser Arg Glu Gly Ala Gln Lys Glu Tyr Val Gln His Lys 
    610                 615                 620                 


Met Met Glu Lys Ala Ala Gln Val Trp Asp Leu Ile Lys Glu Glu Gly 
625                 630                 635                 640 


Tyr Leu Tyr Val Cys Gly Asp Ala Lys Gly Met Ala Arg Asp Val His 
                645                 650                 655     


Arg Thr Leu His Thr Ile Val Gln Glu Gln Glu Gly Val Ser Ser Ser 
            660                 665                 670         


Glu Ala Glu Ala Ile Val Lys Lys Leu Gln Thr Glu Gly Arg Tyr Leu 
        675                 680                 685             


Arg Asp Val Trp 
    690         


<210>  9
<211>  1539
<212>  DNA
<213>  Cosmos sulphureus

<400>  9
atgaccattc tgccgctgct gctgtatccg agtctgaccg cactgctgct gtacgtgctg       60

ctgaatctgc gcccgcgcca tccgaatcgt ctgccgcctg gtccgagccc gtggcctatt      120

gtgggtaatc tgccgcatct gggcgcaagt ccgcatcaga gcctggcaac cctggcagca      180

aaatatggcc cgctgatgta tctgcgtctg ggttttgttg atgttgtggt ggcagccagt      240

gccagtgtgg cagcacagtt tctgaaagtg catgatctga attttgccag tcgcccgctg      300

agcagcggtg gcaaatatat tgcctataat tatcaggata tggtgtttgc accgtatggt      360

ccgcgctggc gtatgctgcg caaaatttgt agcgttcaca tgtttagtgc aaaagcaatg      420

gatggctttc gccatgttcg tcaggaagaa gttgccattc tgacccgcac cctggttagt      480

gccggtaaaa gtccggttaa actgggccag attctgaatg tttgcaccac caatgccctg      540

gcacgtgttg tgctgggtcg tcgtgtgttt gcagatggca gcgcaggtgg tgacccgaaa      600

gcagatgagt ttaaagatat ggttgttgaa ctgatggtgc tggcaggcga atttcatatt      660

ggtgacttta ttccggccct ggattggctg gatctgcagg gtattaagaa taagatgaaa      720

aaactgcacg cccgttttga tagttttctg catggcattc tggaagaaca taaaagcggt      780

aaatttggcg caccgagtca tggtgacctg ctgagtaccc tgattagtct gaaagatgat      840

gcagatggtg aaggcggcaa actgagcgat gttgaaatta aggccctgct gctgaatctt      900

tttgtggccg gcaccgatac cagcagtagc accgttgaat gggcaattgc agaactgatt      960

cgtcatccga aactgctgaa acaggcacag aaagaaatgg ataatgtggt gggccgcgat     1020

cgtctggtga ccgaactgga tctgaatgaa ctgaattttc tgcaggcaat tgttaaagaa     1080

acctttcgtc tgcatccgag taccccgctg agcctgccgc gcattgcaag cgaaagctgt     1140

gaagtggatg gctattatat tccgaaaggc agtaccctgc tggtgaatgt gtgggccatt     1200

gcacgtgatc cgaatgtgtg ggcagatccg ctggaatttc gtccgatgcg ttttctgccg     1260

ggcggtgaaa aaccgaatgt tgatgtgcag ggtaataatt ttgaagttat tccgtttggc     1320

gcaggccgtc gtatttgcgt gggtattagt ctgggtctgc gcatggtgca gctgctggtg     1380

gcaaccctgg tgcagacctt tgattgggaa ctggcaaatg gtctgaatcc ggaaaaactg     1440

aatatggatg aagcatttgg cctgaccctg cagaaagccg aaccgctgat ggtgcatccg     1500

atgccgcgcc tggcaccgca tgtttatggt agtcattaa                            1539


<210>  10
<211>  512
<212>  PRT
<213>  Cosmos sulphureus

<400>  10

Met Thr Ile Leu Pro Leu Leu Leu Tyr Pro Ser Leu Thr Ala Leu Leu 
1               5                   10                  15      


Leu Tyr Val Leu Leu Asn Leu Arg Pro Arg His Pro Asn Arg Leu Pro 
            20                  25                  30          


Pro Gly Pro Ser Pro Trp Pro Ile Val Gly Asn Leu Pro His Leu Gly 
        35                  40                  45              


Ala Ser Pro His Gln Ser Leu Ala Thr Leu Ala Ala Lys Tyr Gly Pro 
    50                  55                  60                  


Leu Met Tyr Leu Arg Leu Gly Phe Val Asp Val Val Val Ala Ala Ser 
65                  70                  75                  80  


Ala Ser Val Ala Ala Gln Phe Leu Lys Val His Asp Leu Asn Phe Ala 
                85                  90                  95      


Ser Arg Pro Leu Ser Ser Gly Gly Lys Tyr Ile Ala Tyr Asn Tyr Gln 
            100                 105                 110         


Asp Met Val Phe Ala Pro Tyr Gly Pro Arg Trp Arg Met Leu Arg Lys 
        115                 120                 125             


Ile Cys Ser Val His Met Phe Ser Ala Lys Ala Met Asp Gly Phe Arg 
    130                 135                 140                 


His Val Arg Gln Glu Glu Val Ala Ile Leu Thr Arg Thr Leu Val Ser 
145                 150                 155                 160 


Ala Gly Lys Ser Pro Val Lys Leu Gly Gln Ile Leu Asn Val Cys Thr 
                165                 170                 175     


Thr Asn Ala Leu Ala Arg Val Val Leu Gly Arg Arg Val Phe Ala Asp 
            180                 185                 190         


Gly Ser Ala Gly Gly Asp Pro Lys Ala Asp Glu Phe Lys Asp Met Val 
        195                 200                 205             


Val Glu Leu Met Val Leu Ala Gly Glu Phe His Ile Gly Asp Phe Ile 
    210                 215                 220                 


Pro Ala Leu Asp Trp Leu Asp Leu Gln Gly Ile Lys Asn Lys Met Lys 
225                 230                 235                 240 


Lys Leu His Ala Arg Phe Asp Ser Phe Leu His Gly Ile Leu Glu Glu 
                245                 250                 255     


His Lys Ser Gly Lys Phe Gly Ala Pro Ser His Gly Asp Leu Leu Ser 
            260                 265                 270         


Thr Leu Ile Ser Leu Lys Asp Asp Ala Asp Gly Glu Gly Gly Lys Leu 
        275                 280                 285             


Ser Asp Val Glu Ile Lys Ala Leu Leu Leu Asn Leu Phe Val Ala Gly 
    290                 295                 300                 


Thr Asp Thr Ser Ser Ser Thr Val Glu Trp Ala Ile Ala Glu Leu Ile 
305                 310                 315                 320 


Arg His Pro Lys Leu Leu Lys Gln Ala Gln Lys Glu Met Asp Asn Val 
                325                 330                 335     


Val Gly Arg Asp Arg Leu Val Thr Glu Leu Asp Leu Asn Glu Leu Asn 
            340                 345                 350         


Phe Leu Gln Ala Ile Val Lys Glu Thr Phe Arg Leu His Pro Ser Thr 
        355                 360                 365             


Pro Leu Ser Leu Pro Arg Ile Ala Ser Glu Ser Cys Glu Val Asp Gly 
    370                 375                 380                 


Tyr Tyr Ile Pro Lys Gly Ser Thr Leu Leu Val Asn Val Trp Ala Ile 
385                 390                 395                 400 


Ala Arg Asp Pro Asn Val Trp Ala Asp Pro Leu Glu Phe Arg Pro Met 
                405                 410                 415     


Arg Phe Leu Pro Gly Gly Glu Lys Pro Asn Val Asp Val Gln Gly Asn 
            420                 425                 430         


Asn Phe Glu Val Ile Pro Phe Gly Ala Gly Arg Arg Ile Cys Val Gly 
        435                 440                 445             


Ile Ser Leu Gly Leu Arg Met Val Gln Leu Leu Val Ala Thr Leu Val 
    450                 455                 460                 


Gln Thr Phe Asp Trp Glu Leu Ala Asn Gly Leu Asn Pro Glu Lys Leu 
465                 470                 475                 480 


Asn Met Asp Glu Ala Phe Gly Leu Thr Leu Gln Lys Ala Glu Pro Leu 
                485                 490                 495     


Met Val His Pro Met Pro Arg Leu Ala Pro His Val Tyr Gly Ser His 
            500                 505                 510         


<210>  11
<211>  1155
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  11
atgtccaaga gcaaaacttt cttatttacc tctgaatccg tcggtgaagg tcacccagac       60

aagatttgtg accaagtttc tgatgctatt ttggacgctt gtttagaaca agatccattc      120

tccaaggttg cctgtgaaac agctgccaaa actggtatga ttatggtttt cggtgaaatt      180

accaccaaag ctagacttga ctaccaacaa atagtaagag ataccatcaa gaagattggt      240

tatgacgatt ctgccaaggg tttcgactac aagacatgta atgttttagt agctatcgaa      300

caacaatctc cagatatcgc tcaaggtctg cactatgaaa agagcttaga agacttaggt      360

gctggtgacc aaggtataat gtttggttac gctacagacg aaactccaga agggttacca      420

ttgaccattc ttttggctca caaattgaac atggctatgg cagatgctag aagagatggt      480

tctctcccat ggttgagacc agacacaaag actcaagtca ctgtcgaata cgaagacgac      540

aatggtagat gggttccaaa gaggatagat accgttgtta tttctgctca acatgctgat      600

gaaatttcca ccgctgactt gagaactcaa cttcaaaaag atattgttga aaaggtcata      660

ccaaaggata tgttagacga aaataccaaa tatttcatcc aaccatccgg tagattcgtc      720

atcggtggtc ctcaaggtga cgctggtttg accggtagaa agattattgt cgacgcttac      780

ggtggtgcct catccgtcgg tggtggtgcc ttctccggta aggactattc caaggtcgat      840

cgttccgctg cttacgctgc tagatgggtt gccaagtctc tagttgccgc tggtttgtgt      900

aagagagtcc aagtccaatt ttcatatgct attggtattg ctgaaccatt gtctttacat      960

gtggacacct atggtacagc tacaaaatca gatgacgaaa tcattgaaat tattaagaag     1020

aacttcgact tgagaccagg tgtgttagta aaggaattag atttggctag accaatttac     1080

ttaccaaccg cttcttatgg tcacttcact aatcaagagt actcatggga aaaaccaaag     1140

aaattggaat tttaa                                                      1155


<210>  12
<211>  384
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  12

Met Ser Lys Ser Lys Thr Phe Leu Phe Thr Ser Glu Ser Val Gly Glu 
1               5                   10                  15      


Gly His Pro Asp Lys Ile Cys Asp Gln Val Ser Asp Ala Ile Leu Asp 
            20                  25                  30          


Ala Cys Leu Glu Gln Asp Pro Phe Ser Lys Val Ala Cys Glu Thr Ala 
        35                  40                  45              


Ala Lys Thr Gly Met Ile Met Val Phe Gly Glu Ile Thr Thr Lys Ala 
    50                  55                  60                  


Arg Leu Asp Tyr Gln Gln Ile Val Arg Asp Thr Ile Lys Lys Ile Gly 
65                  70                  75                  80  


Tyr Asp Asp Ser Ala Lys Gly Phe Asp Tyr Lys Thr Cys Asn Val Leu 
                85                  90                  95      


Val Ala Ile Glu Gln Gln Ser Pro Asp Ile Ala Gln Gly Leu His Tyr 
            100                 105                 110         


Glu Lys Ser Leu Glu Asp Leu Gly Ala Gly Asp Gln Gly Ile Met Phe 
        115                 120                 125             


Gly Tyr Ala Thr Asp Glu Thr Pro Glu Gly Leu Pro Leu Thr Ile Leu 
    130                 135                 140                 


Leu Ala His Lys Leu Asn Met Ala Met Ala Asp Ala Arg Arg Asp Gly 
145                 150                 155                 160 


Ser Leu Pro Trp Leu Arg Pro Asp Thr Lys Thr Gln Val Thr Val Glu 
                165                 170                 175     


Tyr Glu Asp Asp Asn Gly Arg Trp Val Pro Lys Arg Ile Asp Thr Val 
            180                 185                 190         


Val Ile Ser Ala Gln His Ala Asp Glu Ile Ser Thr Ala Asp Leu Arg 
        195                 200                 205             


Thr Gln Leu Gln Lys Asp Ile Val Glu Lys Val Ile Pro Lys Asp Met 
    210                 215                 220                 


Leu Asp Glu Asn Thr Lys Tyr Phe Ile Gln Pro Ser Gly Arg Phe Val 
225                 230                 235                 240 


Ile Gly Gly Pro Gln Gly Asp Ala Gly Leu Thr Gly Arg Lys Ile Ile 
                245                 250                 255     


Val Asp Ala Tyr Gly Gly Ala Ser Ser Val Gly Gly Gly Ala Phe Ser 
            260                 265                 270         


Gly Lys Asp Tyr Ser Lys Val Asp Arg Ser Ala Ala Tyr Ala Ala Arg 
        275                 280                 285             


Trp Val Ala Lys Ser Leu Val Ala Ala Gly Leu Cys Lys Arg Val Gln 
    290                 295                 300                 


Val Gln Phe Ser Tyr Ala Ile Gly Ile Ala Glu Pro Leu Ser Leu His 
305                 310                 315                 320 


Val Asp Thr Tyr Gly Thr Ala Thr Lys Ser Asp Asp Glu Ile Ile Glu 
                325                 330                 335     


Ile Ile Lys Lys Asn Phe Asp Leu Arg Pro Gly Val Leu Val Lys Glu 
            340                 345                 350         


Leu Asp Leu Ala Arg Pro Ile Tyr Leu Pro Thr Ala Ser Tyr Gly His 
        355                 360                 365             


Phe Thr Asn Gln Glu Tyr Ser Trp Glu Lys Pro Lys Lys Leu Glu Phe 
    370                 375                 380                 


<210>  13
<211>  663
<212>  DNA
<213>  Myxococcus xanthus

<400>  13
atgatccacc acgtcgaatt gacacagtcc gtcctgcagt acatccgcga cagttccgtg       60

agggacaacg acatccttcg cgacctgcga gaggagacgt cgaagctccc cctgcgcacg      120

atgcagattc ctcccgagca ggggcagctc ctgagcctgc tggtgcgcct catcggcgcg      180

cgcaagacgc tcgaggtggg cgtcttcacc ggctatagca ccctgtgtgc cgcgctcgcg      240

ctgcccgccg atgggcgcgt catcgcgtgc gacctgagcg aggagtgggt ctccatcgcg      300

cgccgctact ggcagcgggc gggcgtggcg gatcgcatcg aggtccggct tggcgacgcc      360

caccattccc tggaggcgct ggtcggcagc gagcaccgcg ggacgttcga cctcgcgttc      420

atcgatgcgg acaaggagag ctacgacttc tactacgagc acgcgctgcg gctggtgcgt      480

cccggcgggt tgatcatcct cgacaacacg ctgtggtccg ggaaggtcgc cgacccgagc      540

gtcgtcgggg acccggagac ggactcgctg cggcgcatca acgccaagct cctgactgac      600

gaacgggtgg acctcagcat gctcccaatc gctgacggac tgaccctcgc tcgcaagcgc      660

tag                                                                    663


<210>  14
<211>  220
<212>  PRT
<213>  Myxococcus xanthus

<400>  14

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  15
<211>  1095
<212>  DNA
<213>  Pinus sylvestris

<400>  15
atgggttctg cgtctgaatc ttctgaaatg aacgcgaaaa tcgttaacga agacgaatgg       60

ctgctgggta tggaactggg taacttctct tgcgttccga tggcgatgaa agcggcgatc      120

gaactggacg ttctgcagat catcgcgaac gcgggtaacg gtgttcagct gtctccgcgt      180

cagatcgttg cgcacatccc gaccaccaac ccggacgcgg cgatcaccct ggaccgtatc      240

ctgcgtgttc tggcgtctca ctctgttctg tcttgctctg ttaccaccga cgaaaacggt      300

aaagcggaac gtctgtacgg tctgaccccg ctgtgcaaat acctggttaa aaaccaggac      360

ggtgtttctc tggcgccgct ggttctgatg aaccaggaca aagttctgat ggaatcttgg      420

tactacctga aagacgcggt tctggacggt tctcagccgt tcaccaaagc gcacggtatg      480

aacgcgttcg aatacccggc gatggaccag cgtttcaacc gtgttttcaa ccgtggtatg      540

gcggaacact ctaccatgct gatgaacaaa atcctggaca cctacgaagg tttcaaagaa      600

gttcaggaac tggttgacgt tggtggtggt gttggttcta ccctgaacct gatcgtttct      660

aaatacccgc acatctctgg tatcaacttc gacatgccgc acgttgttgc ggacgcgccg      720

cactacccgg cggttaaaca cgttggtggt gacatgttcg actctgttcc gtctggtcag      780

gcgatcttca tgaaatggat tttacacgac tggtctgacg accactgcct gcgtctgctg      840

aaaaactgcc acaaagcgct gccggaaaaa ggtaaagtta tcgttgttga caccatcctg      900

ccggttgcgg cggaaacctc tccgtacgcg cgtcagggtt tccacatcga cctgctgatg      960

ctggcgtaca acccgggtgg taaagaacgt accgaacagg aattccgtga cctggcgaaa     1020

gaagttggtt tcgcgggtgg tgttaaaccg gtttgctgcg ttaacggtca ctgggttatg     1080

gaattccaca aatag                                                      1095


<210>  16
<211>  364
<212>  PRT
<213>  Pinus sylvestris

<400>  16

Met Gly Ser Ala Ser Glu Ser Ser Glu Met Asn Ala Lys Ile Val Asn 
1               5                   10                  15      


Glu Asp Glu Trp Leu Leu Gly Met Glu Leu Gly Asn Phe Ser Cys Val 
            20                  25                  30          


Pro Met Ala Met Lys Ala Ala Ile Glu Leu Asp Val Leu Gln Ile Ile 
        35                  40                  45              


Ala Asn Ala Gly Asn Gly Val Gln Leu Ser Pro Arg Gln Ile Val Ala 
    50                  55                  60                  


His Ile Pro Thr Thr Asn Pro Asp Ala Ala Ile Thr Leu Asp Arg Ile 
65                  70                  75                  80  


Leu Arg Val Leu Ala Ser His Ser Val Leu Ser Cys Ser Val Thr Thr 
                85                  90                  95      


Asp Glu Asn Gly Lys Ala Glu Arg Leu Tyr Gly Leu Thr Pro Leu Cys 
            100                 105                 110         


Lys Tyr Leu Val Lys Asn Gln Asp Gly Val Ser Leu Ala Pro Leu Val 
        115                 120                 125             


Leu Met Asn Gln Asp Lys Val Leu Met Glu Ser Trp Tyr Tyr Leu Lys 
    130                 135                 140                 


Asp Ala Val Leu Asp Gly Ser Gln Pro Phe Thr Lys Ala His Gly Met 
145                 150                 155                 160 


Asn Ala Phe Glu Tyr Pro Ala Met Asp Gln Arg Phe Asn Arg Val Phe 
                165                 170                 175     


Asn Arg Gly Met Ala Glu His Ser Thr Met Leu Met Asn Lys Ile Leu 
            180                 185                 190         


Asp Thr Tyr Glu Gly Phe Lys Glu Val Gln Glu Leu Val Asp Val Gly 
        195                 200                 205             


Gly Gly Val Gly Ser Thr Leu Asn Leu Ile Val Ser Lys Tyr Pro His 
    210                 215                 220                 


Ile Ser Gly Ile Asn Phe Asp Met Pro His Val Val Ala Asp Ala Pro 
225                 230                 235                 240 


His Tyr Pro Ala Val Lys His Val Gly Gly Asp Met Phe Asp Ser Val 
                245                 250                 255     


Pro Ser Gly Gln Ala Ile Phe Met Lys Trp Ile Leu His Asp Trp Ser 
            260                 265                 270         


Asp Asp His Cys Leu Arg Leu Leu Lys Asn Cys His Lys Ala Leu Pro 
        275                 280                 285             


Glu Lys Gly Lys Val Ile Val Val Asp Thr Ile Leu Pro Val Ala Ala 
    290                 295                 300                 


Glu Thr Ser Pro Tyr Ala Arg Gln Gly Phe His Ile Asp Leu Leu Met 
305                 310                 315                 320 


Leu Ala Tyr Asn Pro Gly Gly Lys Glu Arg Thr Glu Gln Glu Phe Arg 
                325                 330                 335     


Asp Leu Ala Lys Glu Val Gly Phe Ala Gly Gly Val Lys Pro Val Cys 
            340                 345                 350         


Cys Val Asn Gly His Trp Val Met Glu Phe His Lys 
        355                 360                 


<210>  17
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  17
cgaaacgatg agatttcctt ca                                                22


<210>  18
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  18
agatctgatc tcatgaccaa aatcc                                             25


<210>  19
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  19
ggattttggt catgagatca gatctttttt gtagaaatgt cttggtgtcc t                51


<210>  20
<211>  55
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  20
aattgaagga aatctcatcg tttcgatagt tgttcaattg attgaaatag ggaca            55


<210>  21
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  21
cacgtccgac ggcggccca                                                    19


<210>  22
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  22
ggtttagttc ctcaccttgt cg                                                22


<210>  23
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  23
atacgacaag gtgaggaact aaaccatgag ccatattcaa cgggaaac                    48


<210>  24
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  24
gacccgtggg ccgccgtcgg acgtgttaga aaaactcatc gagcatca                    48


<210>  25
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  25
gtttgtagcc ttagacatga ctgt                                              24


<210>  26
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  26
cgtttcgata gttgttcaat tgattgaaat agggaca                                37


<210>  27
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  27
aatcaattga acaactatcg aaacgatgac cagcgccctg tatgcaa                     47


<210>  28
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  28
aacagtcatg tctaaggcta caaacttacc acacatcacg cagataac                    48


<210>  29
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  29
aatcaattga acaactatcg aaacgatgac cattctgccg ctgct                       45


<210>  30
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  30
aacagtcatg tctaaggcta caaacttaat gactaccata aacatgcggt                  50


<210>  31
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  31
caatcaattg aacaactatc gaaacgatgt ccaagagcaa aactttct                    48


<210>  32
<211>  56
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  32
gaacagtcat gtctaaggct acaaacttaa aattccaatt tctttggttt ttccca           56


<210>  33
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  33
aatcaattga acaactatcg aaacgatgat ccaccacgtc gaattga                     47


<210>  34
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  34
aacagtcatg tctaaggcta caaacctagc gcttgcgagc gagggtc                     47


<210>  35
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  35
aatcaattga acaactatcg aaacgatggg ttctgcgtct gaatctt                     47


<210>  36
<211>  49
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  36
aacagtcatg tctaaggcta caaacctatt tgtggaattc cataaccca                   49


<210>  37
<211>  1203
<212>  DNA
<213>  Bacillus subtilis

<400>  37
atgagcaaga atcgtcgtct gtttacctca gaatcggtga ctgaaggcca tccggataaa       60

atctgcgatc agattagcga ttccattctg gacgagattc tgaagaaaga cccaaatgcg      120

cgcgttgcat gcgaaacgtc tgtcaccacc gggttggtct tagtgagcgg cgaaattaca      180

acttccacgt atgtggacat tccgaaaacc gttcggcaga ccatcaaaga gattggctac      240

actcgcgcga aatacggatt tgacgcggaa acctgtgcag ttctgacctc gattgacgaa      300

cagtcagcgg atattgcaat gggtgtcgac caagcccttg aagcccgcga aggaacgatg      360

tcagacgaag aaattgaagc cattggggct ggcgatcaag gcctgatgtt cggttatgcg      420

tgcaacgaaa ccaaagagtt aatgccgctg cccatcagtc tggcgcacaa actggcacgt      480

cgcttgagcg aagtgcgcaa agaggatatc ctgccgtatt tacgccctga tgggaaaacc      540

caggtcaccg tggaatacga tgagaacaac aaaccggtac gcattgacgc gattgtgatt      600

tctacgcagc atcatccaga gatcactctt gaacagatcc aacgcaacat caaagaacac      660

gtgatcaatc cggtagttcc ggaagaactg atcgacgaag aaaccaaata cttcatcaac      720

ccgacagggc gttttgtaat tggcggtcca cagggtgatg ctggccttac aggccgcaaa      780

atcattgtgg atacctatgg tgggtatgcg cgccatggag gtggtgcctt tagtggcaag      840

gatgcaacga aagtggatcg gagcgctgca tatgccgcgc gttatgttgc gaagaacatt      900

gttgctgcgg agttagcaga ttcgtgtgaa gtccagttgg cctatgccat tggtgttgcc      960

caacctgtca gcatttccat caacacattc ggttctggca aagcgagtga ggagaaactg     1020

atcgaagtgg tgcgcaataa tttcgatctc cgtcctgccg gcattattaa gatgctcgat     1080

ctccgccgtc cgatctacaa acaaacggct gcctacggtc attttggccg tcacgacgta     1140

gatctgccct gggaacgtac ggataaggcg gaacagctgc gcaaagaggc tctgggcgag     1200

taa                                                                   1203


<210>  38
<211>  400
<212>  PRT
<213>  Bacillus subtilis

<400>  38

Met Ser Lys Asn Arg Arg Leu Phe Thr Ser Glu Ser Val Thr Glu Gly 
1               5                   10                  15      


His Pro Asp Lys Ile Cys Asp Gln Ile Ser Asp Ser Ile Leu Asp Glu 
            20                  25                  30          


Ile Leu Lys Lys Asp Pro Asn Ala Arg Val Ala Cys Glu Thr Ser Val 
        35                  40                  45              


Thr Thr Gly Leu Val Leu Val Ser Gly Glu Ile Thr Thr Ser Thr Tyr 
    50                  55                  60                  


Val Asp Ile Pro Lys Thr Val Arg Gln Thr Ile Lys Glu Ile Gly Tyr 
65                  70                  75                  80  


Thr Arg Ala Lys Tyr Gly Phe Asp Ala Glu Thr Cys Ala Val Leu Thr 
                85                  90                  95      


Ser Ile Asp Glu Gln Ser Ala Asp Ile Ala Met Gly Val Asp Gln Ala 
            100                 105                 110         


Leu Glu Ala Arg Glu Gly Thr Met Ser Asp Glu Glu Ile Glu Ala Ile 
        115                 120                 125             


Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Cys Asn Glu Thr 
    130                 135                 140                 


Lys Glu Leu Met Pro Leu Pro Ile Ser Leu Ala His Lys Leu Ala Arg 
145                 150                 155                 160 


Arg Leu Ser Glu Val Arg Lys Glu Asp Ile Leu Pro Tyr Leu Arg Pro 
                165                 170                 175     


Asp Gly Lys Thr Gln Val Thr Val Glu Tyr Asp Glu Asn Asn Lys Pro 
            180                 185                 190         


Val Arg Ile Asp Ala Ile Val Ile Ser Thr Gln His His Pro Glu Ile 
        195                 200                 205             


Thr Leu Glu Gln Ile Gln Arg Asn Ile Lys Glu His Val Ile Asn Pro 
    210                 215                 220                 


Val Val Pro Glu Glu Leu Ile Asp Glu Glu Thr Lys Tyr Phe Ile Asn 
225                 230                 235                 240 


Pro Thr Gly Arg Phe Val Ile Gly Gly Pro Gln Gly Asp Ala Gly Leu 
                245                 250                 255     


Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Tyr Ala Arg His 
            260                 265                 270         


Gly Gly Gly Ala Phe Ser Gly Lys Asp Ala Thr Lys Val Asp Arg Ser 
        275                 280                 285             


Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Ile Val Ala Ala Glu 
    290                 295                 300                 


Leu Ala Asp Ser Cys Glu Val Gln Leu Ala Tyr Ala Ile Gly Val Ala 
305                 310                 315                 320 


Gln Pro Val Ser Ile Ser Ile Asn Thr Phe Gly Ser Gly Lys Ala Ser 
                325                 330                 335     


Glu Glu Lys Leu Ile Glu Val Val Arg Asn Asn Phe Asp Leu Arg Pro 
            340                 345                 350         


Ala Gly Ile Ile Lys Met Leu Asp Leu Arg Arg Pro Ile Tyr Lys Gln 
        355                 360                 365             


Thr Ala Ala Tyr Gly His Phe Gly Arg His Asp Val Asp Leu Pro Trp 
    370                 375                 380                 


Glu Arg Thr Asp Lys Ala Glu Gln Leu Arg Lys Glu Ala Leu Gly Glu 
385                 390                 395                 400 


<210>  39
<211>  1203
<212>  DNA
<213>  Bacillus subtilis

<400>  39
atgagcaaga atcgtcgtct gtttacctca gaatcggtga ctgaaggcca tccggataaa       60

atctgcgatc agattagcga ttccattctg gacgagattc tgaagaaaga cccaaatgcg      120

cgcgttgcat gcgaaacgtc tgtcaccacc gggttggtct tagtgagcgg cgaaattaca      180

acttccacgt atgtggacat tccgaaaacc gttcggcaga ccatcaaaga gattggctac      240

actcgcgcga aatacggatt tgacgcggaa acctgtgcag ttctgacctc gattgacgaa      300

cagtcagcgg atattgcaat gggtgtcgac caagcccttg aagcccgcga aggaacgatg      360

tcagacgaag aaattgaagc cattggggct ggcgatcaag gcctgatgtt cggttatgcg      420

tgcaacgaaa ccaaagagtt aatgccgctg cccatcagtc tggcgcacaa actggcacgt      480

cgcttgagcg aagtgcgcaa agaggatatc ctgccgtatt tacgccctga tgggaaaacc      540

caggtcaccg tggaatacga tgagaacaac aaaccggtac gcattgacgc gattgtgatt      600

tctacgcagc atcatccaga gatcactctt gaacagatcc aacgcaacat caaagaacac      660

gtgatcaatc cggtagttcc ggaagaactg atcgacgaag aaaccaaata cttcatcaac      720

ccgacagggc gttttgtaat tggcggtcca cagggtgatg ctggccttac aggccgcaaa      780

atcattgtgg atacctatgg tgggtatgcg cgccatggag gtggtgcctt tagtggcaag      840

gatgcaacga aagtggatcg gagcgctgca tatgccgcgc gttatgttgc gaagaacatt      900

gttgctgcgg agttagcaga ttcgtgtgaa gtccagttgg cctatgccgt tggtgttgcc      960

caacctgtca gcatttccat caacacattc ggttctggca aagcgagtga ggagaaactg     1020

atcgaagtgg tgcgcaataa tttcgatctc cgtcctgccg gcattattaa gatgctcgat     1080

ctccgccgtc cgatctacaa acaaacggct gcctacggtc attttggccg tcacgacgta     1140

gatctgccct gggaacgtac ggataaggcg gaacagctgc gcaaagaggc tctgggcgag     1200

taa                                                                   1203


<210>  40
<211>  400
<212>  PRT
<213>  Bacillus subtilis

<400>  40

Met Ser Lys Asn Arg Arg Leu Phe Thr Ser Glu Ser Val Thr Glu Gly 
1               5                   10                  15      


His Pro Asp Lys Ile Cys Asp Gln Ile Ser Asp Ser Ile Leu Asp Glu 
            20                  25                  30          


Ile Leu Lys Lys Asp Pro Asn Ala Arg Val Ala Cys Glu Thr Ser Val 
        35                  40                  45              


Thr Thr Gly Leu Val Leu Val Ser Gly Glu Ile Thr Thr Ser Thr Tyr 
    50                  55                  60                  


Val Asp Ile Pro Lys Thr Val Arg Gln Thr Ile Lys Glu Ile Gly Tyr 
65                  70                  75                  80  


Thr Arg Ala Lys Tyr Gly Phe Asp Ala Glu Thr Cys Ala Val Leu Thr 
                85                  90                  95      


Ser Ile Asp Glu Gln Ser Ala Asp Ile Ala Met Gly Val Asp Gln Ala 
            100                 105                 110         


Leu Glu Ala Arg Glu Gly Thr Met Ser Asp Glu Glu Ile Glu Ala Ile 
        115                 120                 125             


Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Cys Asn Glu Thr 
    130                 135                 140                 


Lys Glu Leu Met Pro Leu Pro Ile Ser Leu Ala His Lys Leu Ala Arg 
145                 150                 155                 160 


Arg Leu Ser Glu Val Arg Lys Glu Asp Ile Leu Pro Tyr Leu Arg Pro 
                165                 170                 175     


Asp Gly Lys Thr Gln Val Thr Val Glu Tyr Asp Glu Asn Asn Lys Pro 
            180                 185                 190         


Val Arg Ile Asp Ala Ile Val Ile Ser Thr Gln His His Pro Glu Ile 
        195                 200                 205             


Thr Leu Glu Gln Ile Gln Arg Asn Ile Lys Glu His Val Ile Asn Pro 
    210                 215                 220                 


Val Val Pro Glu Glu Leu Ile Asp Glu Glu Thr Lys Tyr Phe Ile Asn 
225                 230                 235                 240 


Pro Thr Gly Arg Phe Val Ile Gly Gly Pro Gln Gly Asp Ala Gly Leu 
                245                 250                 255     


Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Tyr Ala Arg His 
            260                 265                 270         


Gly Gly Gly Ala Phe Ser Gly Lys Asp Ala Thr Lys Val Asp Arg Ser 
        275                 280                 285             


Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Val Val Ala Ala Glu 
    290                 295                 300                 


Leu Ala Asp Ser Cys Glu Val Gln Leu Ala Tyr Ala Ile Gly Val Ala 
305                 310                 315                 320 


Gln Pro Val Ser Ile Ser Ile Asn Thr Phe Gly Ser Gly Lys Ala Ser 
                325                 330                 335     


Glu Glu Lys Leu Ile Glu Val Val Arg Asn Asn Phe Asp Leu Arg Pro 
            340                 345                 350         


Ala Gly Ile Ile Lys Met Leu Asp Leu Arg Arg Pro Ile Tyr Lys Gln 
        355                 360                 365             


Thr Ala Ala Tyr Gly His Phe Gly Arg His Asp Val Asp Leu Pro Trp 
    370                 375                 380                 


Glu Arg Thr Asp Lys Ala Glu Gln Leu Arg Lys Glu Ala Leu Gly Glu 
385                 390                 395                 400 


<210>  41
<211>  1155
<212>  DNA
<213>  Escherichia coli

<400>  41
atggcaaaac acctttttac gtccgagtcc gtctctgaag ggcatcctga caaaattgct       60

gaccaaattt ctgatgccgt tttagacgcg atcctcgaac aggatccgaa agcacgcgtt      120

gcttgcgaaa cctacgtaaa aaccggcatg gttttagttg gcggcgaaat caccaccagc      180

gcctgggtag acatcgaaga gatcacccgt aacaccgttc gcgaaattgg ctatgtgcat      240

tccgacatgg gctttgacgc taactcctgt gcggttctga gcgctatcgg caaacagtct      300

cctgacatca accagggcgt tgaccgtgcc gatccgctgg aacagggcgc gggtgaccag      360

ggtctgatgt ttggctacgc aactaatgaa accgacgtgc tgatgccagc acctatcacc      420

tatgcacacc gtctggtaca gcgtcaggct gaagtgcgta aaaacggcac tctgccgtgg      480

ctgcgcccgg acgcgaaaag ccaggtgact tttcagtatg acgacggcaa aatcgttggt      540

atcgatgctg tcgtgctttc cactcagcac tctgaagaga tcgaccagaa atcgctgcaa      600

gaagcggtaa tggaagagat catcaagcca attctgcccg ctgaatggct gacttctgcc      660

accaaattct tcatcaaccc gaccggtcgt ttcgttatcg gtggcccaat gggtgactgc      720

ggtctgactg gtcgtaaaat tatcgttgat acctacggcg gcatggcgcg tcacggtggc      780

ggtgcattct ctggtaaaga tccatcaaaa gtggaccgtt ccgcagccta cgcagcacgt      840

tatgtcgcga aaaacatcgt tgctgctggc ctggccgatc gttgtgaaat tcaggtttcc      900

tacgcaatcg gcgtggctga accgacctcc atcatggtag aaactttcgg tactgagaaa      960

gtgccttctg aacaactgac cctgctggta cgtgagttct tcgacctgcg cccatacggt     1020

ctgattcaga tgctggatct gctgcacccg atctacaaag aaaccgcagc atacggtcac     1080

tttggtcgtg aacatttccc gtgggaaaaa accgacaaag cgcagctgct gcgcgatgct     1140

gccggtctga agtaa                                                      1155


<210>  42
<211>  384
<212>  PRT
<213>  Escherichia coli

<400>  42

Met Ala Lys His Leu Phe Thr Ser Glu Ser Val Ser Glu Gly His Pro 
1               5                   10                  15      


Asp Lys Ile Ala Asp Gln Ile Ser Asp Ala Val Leu Asp Ala Ile Leu 
            20                  25                  30          


Glu Gln Asp Pro Lys Ala Arg Val Ala Cys Glu Thr Tyr Val Lys Thr 
        35                  40                  45              


Gly Met Val Leu Val Gly Gly Glu Ile Thr Thr Ser Ala Trp Val Asp 
    50                  55                  60                  


Ile Glu Glu Ile Thr Arg Asn Thr Val Arg Glu Ile Gly Tyr Val His 
65                  70                  75                  80  


Ser Asp Met Gly Phe Asp Ala Asn Ser Cys Ala Val Leu Ser Ala Ile 
                85                  90                  95      


Gly Lys Gln Ser Pro Asp Ile Asn Gln Gly Val Asp Arg Ala Asp Pro 
            100                 105                 110         


Leu Glu Gln Gly Ala Gly Asp Gln Gly Leu Met Phe Gly Tyr Ala Thr 
        115                 120                 125             


Asn Glu Thr Asp Val Leu Met Pro Ala Pro Ile Thr Tyr Ala His Arg 
    130                 135                 140                 


Leu Val Gln Arg Gln Ala Glu Val Arg Lys Asn Gly Thr Leu Pro Trp 
145                 150                 155                 160 


Leu Arg Pro Asp Ala Lys Ser Gln Val Thr Phe Gln Tyr Asp Asp Gly 
                165                 170                 175     


Lys Ile Val Gly Ile Asp Ala Val Val Leu Ser Thr Gln His Ser Glu 
            180                 185                 190         


Glu Ile Asp Gln Lys Ser Leu Gln Glu Ala Val Met Glu Glu Ile Ile 
        195                 200                 205             


Lys Pro Ile Leu Pro Ala Glu Trp Leu Thr Ser Ala Thr Lys Phe Phe 
    210                 215                 220                 


Ile Asn Pro Thr Gly Arg Phe Val Ile Gly Gly Pro Met Gly Asp Cys 
225                 230                 235                 240 


Gly Leu Thr Gly Arg Lys Ile Ile Val Asp Thr Tyr Gly Gly Met Ala 
                245                 250                 255     


Arg His Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val Asp 
            260                 265                 270         


Arg Ser Ala Ala Tyr Ala Ala Arg Tyr Val Ala Lys Asn Ile Val Ala 
        275                 280                 285             


Ala Gly Leu Ala Asp Arg Cys Glu Ile Gln Val Ser Tyr Ala Ile Gly 
    290                 295                 300                 


Val Ala Glu Pro Thr Ser Ile Met Val Glu Thr Phe Gly Thr Glu Lys 
305                 310                 315                 320 


Val Pro Ser Glu Gln Leu Thr Leu Leu Val Arg Glu Phe Phe Asp Leu 
                325                 330                 335     


Arg Pro Tyr Gly Leu Ile Gln Met Leu Asp Leu Leu His Pro Ile Tyr 
            340                 345                 350         


Lys Glu Thr Ala Ala Tyr Gly His Phe Gly Arg Glu His Phe Pro Trp 
        355                 360                 365             


Glu Lys Thr Asp Lys Ala Gln Leu Leu Arg Asp Ala Ala Gly Leu Lys 
    370                 375                 380                 


<210>  43
<211>  1236
<212>  DNA
<213>  Streptomyces spectabilis

<400>  43
atgtcccgcc gtctcttcac ctcggagtcc gtgaccgagg gtcaccccga caagatcgct       60

gaccagatca gcgacaccat tctcgacgcg cttctgcgtg aggacccgac gtcccgggtc      120

gccgtcgaaa cgctcatcac caccggcctc gtgcacgtcg ccggtgaggt cacgaccaag      180

gcgtacgcgc cgatcgcgca gctggtgcgc gagaagatcc tcgagatcgg atacgactcc      240

tcgaagaagg gcttcgacgg cgcctcctgc ggcgtctcgg tgtccatcgg cgcgcagtcc      300

ccggacatcg cgcagggcgt cgacacggcg tacgagagcc gtgtcgaggg cgacgaggac      360

gagctcgacc ggcagggcgc cggtgaccag ggcctgatgt tcggctacgc ctgcgacgag      420

accccggagc tgatgccgct cccgatccac ctcgcgcacc gcctctcgcg ccgcctctcc      480

gaggtgcgca agaacgggac catcccctac ctgcgccccg acggcaagac ccaggtcacc      540

atcgagtacg acggcgacaa ggccgtccgc ctcgacacgg tcgtcgtctc ctcgcagcac      600

gcgtcggaca tcgacctgga gtcgctgctc gcccccgaca tccgcgagtt cgtcgtcgag      660

ccggagctca aggccctggt cgaggacggc atcaagctgg agaccgaggg ctaccgcctc      720

ctggtcaacc cgaccggccg cttcgagatc ggcggcccga tgggtgacgc gggcctgacc      780

ggccgcaaga tcatcatcga cacctacggc ggcatgtccc gccacggcgg cggcgccttc      840

tccggcaagg acccgtccaa ggtggaccgc tcggcggcgt acgcgatgcg ctgggtcgcc      900

aagaacgtgg tggccgcggg cctcgcctcg cgctgcgagg tccaggtcgc ctacgccatc      960

ggcaaggccg agccggtcgg tctgttcgtc gagaccttcg gcaccaacac gatcgacacg     1020

gacaagatcg agcaggccat cagcgaggtc ttcgacctcc gcccggccgc gatcatccgc     1080

gacctcgacc tgctccgccc gatctactcc cagaccgccg cgtacggcca cttcggccgc     1140

tcgctgccgg agttcacctg ggagaagacg gaccgcgtgg acggctgcgg aaggccgccg     1200

gtctggagag ctgatctcct gccgcttgtt cactga                               1236


<210>  44
<211>  411
<212>  PRT
<213>  Streptomyces spectabilis

<400>  44

Met Ser Arg Arg Leu Phe Thr Ser Glu Ser Val Thr Glu Gly His Pro 
1               5                   10                  15      


Asp Lys Ile Ala Asp Gln Ile Ser Asp Thr Ile Leu Asp Ala Leu Leu 
            20                  25                  30          


Arg Glu Asp Pro Thr Ser Arg Val Ala Val Glu Thr Leu Ile Thr Thr 
        35                  40                  45              


Gly Leu Val His Val Ala Gly Glu Val Thr Thr Lys Ala Tyr Ala Pro 
    50                  55                  60                  


Ile Ala Gln Leu Val Arg Glu Lys Ile Leu Glu Ile Gly Tyr Asp Ser 
65                  70                  75                  80  


Ser Lys Lys Gly Phe Asp Gly Ala Ser Cys Gly Val Ser Val Ser Ile 
                85                  90                  95      


Gly Ala Gln Ser Pro Asp Ile Ala Gln Gly Val Asp Thr Ala Tyr Glu 
            100                 105                 110         


Ser Arg Val Glu Gly Asp Glu Asp Glu Leu Asp Arg Gln Gly Ala Gly 
        115                 120                 125             


Asp Gln Gly Leu Met Phe Gly Tyr Ala Cys Asp Glu Thr Pro Glu Leu 
    130                 135                 140                 


Met Pro Leu Pro Ile His Leu Ala His Arg Leu Ser Arg Arg Leu Ser 
145                 150                 155                 160 


Glu Val Arg Lys Asn Gly Thr Ile Pro Tyr Leu Arg Pro Asp Gly Lys 
                165                 170                 175     


Thr Gln Val Thr Ile Glu Tyr Asp Gly Asp Lys Ala Val Arg Leu Asp 
            180                 185                 190         


Thr Val Val Val Ser Ser Gln His Ala Ser Asp Ile Asp Leu Glu Ser 
        195                 200                 205             


Leu Leu Ala Pro Asp Ile Arg Glu Phe Val Val Glu Pro Glu Leu Lys 
    210                 215                 220                 


Ala Leu Val Glu Asp Gly Ile Lys Leu Glu Thr Glu Gly Tyr Arg Leu 
225                 230                 235                 240 


Leu Val Asn Pro Thr Gly Arg Phe Glu Ile Gly Gly Pro Met Gly Asp 
                245                 250                 255     


Ala Gly Leu Thr Gly Arg Lys Ile Ile Ile Asp Thr Tyr Gly Gly Met 
            260                 265                 270         


Ser Arg His Gly Gly Gly Ala Phe Ser Gly Lys Asp Pro Ser Lys Val 
        275                 280                 285             


Asp Arg Ser Ala Ala Tyr Ala Met Arg Trp Val Ala Lys Asn Val Val 
    290                 295                 300                 


Ala Ala Gly Leu Ala Ser Arg Cys Glu Val Gln Val Ala Tyr Ala Ile 
305                 310                 315                 320 


Gly Lys Ala Glu Pro Val Gly Leu Phe Val Glu Thr Phe Gly Thr Asn 
                325                 330                 335     


Thr Ile Asp Thr Asp Lys Ile Glu Gln Ala Ile Ser Glu Val Phe Asp 
            340                 345                 350         


Leu Arg Pro Ala Ala Ile Ile Arg Asp Leu Asp Leu Leu Arg Pro Ile 
        355                 360                 365             


Tyr Ser Gln Thr Ala Ala Tyr Gly His Phe Gly Arg Ser Leu Pro Glu 
    370                 375                 380                 


Phe Thr Trp Glu Lys Thr Asp Arg Val Asp Gly Cys Gly Arg Pro Pro 
385                 390                 395                 400 


Val Trp Arg Ala Asp Leu Leu Pro Leu Val His 
                405                 410     


<210>  45
<211>  1518
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  45
atgagtgaag gccccgtcaa attcgaaaaa aataccgtca tatctgtctt tggtgcgtca       60

ggtgatctgg caaagaagaa gacttttccc gccttatttg ggcttttcag agaaggttac      120

cttgatccat ctaccaagat cttcggttat gcccggtcca aattgtccat ggaggaggac      180

ctgaagtccc gtgtcctacc ccacttgaaa aaacctcacg gtgaagccga tgactctaag      240

gtcgaacagt tcttcaagat ggtcagctac atttcgggaa attacgacac agatgaaggc      300

ttcgacgaat taagaacgca gatcgagaaa ttcgagaaaa gtgccaacgt cgatgtccca      360

caccgtctct tctatctggc cttgccgcca agcgtttttt tgacggtggc caagcagatc      420

aagagtcgtg tgtacgcaga gaatggcatc acccgtgtaa tcgtagagaa acctttcggc      480

cacgacctgg cctctgccag ggagctgcaa aaaaacctgg ggcccctctt taaagaagaa      540

gagttgtaca gaattgacca ttacttgggt aaagagttgg tcaagaatct tttagtcttg      600

aggttcggta accagttttt gaatgcctcg tggaatagag acaacattca aagcgttcag      660

atttcgttta aagagaggtt cggcaccgaa ggccgtggcg gctatttcga ctctataggc      720

ataatcagag acgtgatgca gaaccatctg ttacaaatca tgactctctt gactatggaa      780

agaccggtgt cttttgaccc ggaatctatt cgtgacgaaa aggttaaggt tctaaaggcc      840

gtggccccca tcgacacgga cgacgtcctc ttgggccagt acggtaaatc tgaggacggg      900

tctaagcccg cctacgtgga tgatgacact gtagacaagg actctaaatg tgtcactttt      960

gcagcaatga ctttcaacat cgaaaacgag cgttgggagg gcgtccccat catgatgcgt     1020

gccggtaagg ctttgaatga gtccaaggtg gagatcagac tgcagtacaa agcggtcgca     1080

tcgggtgtct tcaaagacat tccaaataac gaactggtca tcagagtgca gcccgatgcc     1140

gctgtgtacc taaagtttaa tgctaagacc cctggtctgt caaatgctac ccaagtcaca     1200

gatctgaatc taacttacgc aagcaggtac caagactttt ggattccaga ggcttacgag     1260

gtgttgataa gagacgccct actgggtgac cattccaact ttgtcagaga tgacgaattg     1320

gatatcagtt ggggcatatt caccccatta ctgaagcaca tagagcgtcc ggacggtcca     1380

acaccggaaa tttaccccta cggatcaaga ggtccaaagg gattgaagga atatatgcaa     1440

aaacacaagt atgttatgcc cgaaaagcac ccttacgctt ggcccgtgac taagccagaa     1500

gatacgaagg ataattag                                                   1518


<210>  46
<211>  505
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  46

Met Ser Glu Gly Pro Val Lys Phe Glu Lys Asn Thr Val Ile Ser Val 
1               5                   10                  15      


Phe Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Thr Phe Pro Ala Leu 
            20                  25                  30          


Phe Gly Leu Phe Arg Glu Gly Tyr Leu Asp Pro Ser Thr Lys Ile Phe 
        35                  40                  45              


Gly Tyr Ala Arg Ser Lys Leu Ser Met Glu Glu Asp Leu Lys Ser Arg 
    50                  55                  60                  


Val Leu Pro His Leu Lys Lys Pro His Gly Glu Ala Asp Asp Ser Lys 
65                  70                  75                  80  


Val Glu Gln Phe Phe Lys Met Val Ser Tyr Ile Ser Gly Asn Tyr Asp 
                85                  90                  95      


Thr Asp Glu Gly Phe Asp Glu Leu Arg Thr Gln Ile Glu Lys Phe Glu 
            100                 105                 110         


Lys Ser Ala Asn Val Asp Val Pro His Arg Leu Phe Tyr Leu Ala Leu 
        115                 120                 125             


Pro Pro Ser Val Phe Leu Thr Val Ala Lys Gln Ile Lys Ser Arg Val 
    130                 135                 140                 


Tyr Ala Glu Asn Gly Ile Thr Arg Val Ile Val Glu Lys Pro Phe Gly 
145                 150                 155                 160 


His Asp Leu Ala Ser Ala Arg Glu Leu Gln Lys Asn Leu Gly Pro Leu 
                165                 170                 175     


Phe Lys Glu Glu Glu Leu Tyr Arg Ile Asp His Tyr Leu Gly Lys Glu 
            180                 185                 190         


Leu Val Lys Asn Leu Leu Val Leu Arg Phe Gly Asn Gln Phe Leu Asn 
        195                 200                 205             


Ala Ser Trp Asn Arg Asp Asn Ile Gln Ser Val Gln Ile Ser Phe Lys 
    210                 215                 220                 


Glu Arg Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Ser Ile Gly 
225                 230                 235                 240 


Ile Ile Arg Asp Val Met Gln Asn His Leu Leu Gln Ile Met Thr Leu 
                245                 250                 255     


Leu Thr Met Glu Arg Pro Val Ser Phe Asp Pro Glu Ser Ile Arg Asp 
            260                 265                 270         


Glu Lys Val Lys Val Leu Lys Ala Val Ala Pro Ile Asp Thr Asp Asp 
        275                 280                 285             


Val Leu Leu Gly Gln Tyr Gly Lys Ser Glu Asp Gly Ser Lys Pro Ala 
    290                 295                 300                 


Tyr Val Asp Asp Asp Thr Val Asp Lys Asp Ser Lys Cys Val Thr Phe 
305                 310                 315                 320 


Ala Ala Met Thr Phe Asn Ile Glu Asn Glu Arg Trp Glu Gly Val Pro 
                325                 330                 335     


Ile Met Met Arg Ala Gly Lys Ala Leu Asn Glu Ser Lys Val Glu Ile 
            340                 345                 350         


Arg Leu Gln Tyr Lys Ala Val Ala Ser Gly Val Phe Lys Asp Ile Pro 
        355                 360                 365             


Asn Asn Glu Leu Val Ile Arg Val Gln Pro Asp Ala Ala Val Tyr Leu 
    370                 375                 380                 


Lys Phe Asn Ala Lys Thr Pro Gly Leu Ser Asn Ala Thr Gln Val Thr 
385                 390                 395                 400 


Asp Leu Asn Leu Thr Tyr Ala Ser Arg Tyr Gln Asp Phe Trp Ile Pro 
                405                 410                 415     


Glu Ala Tyr Glu Val Leu Ile Arg Asp Ala Leu Leu Gly Asp His Ser 
            420                 425                 430         


Asn Phe Val Arg Asp Asp Glu Leu Asp Ile Ser Trp Gly Ile Phe Thr 
        435                 440                 445             


Pro Leu Leu Lys His Ile Glu Arg Pro Asp Gly Pro Thr Pro Glu Ile 
    450                 455                 460                 


Tyr Pro Tyr Gly Ser Arg Gly Pro Lys Gly Leu Lys Glu Tyr Met Gln 
465                 470                 475                 480 


Lys His Lys Tyr Val Met Pro Glu Lys His Pro Tyr Ala Trp Pro Val 
                485                 490                 495     


Thr Lys Pro Glu Asp Thr Lys Asp Asn 
            500                 505 


<210>  47
<211>  1515
<212>  DNA
<213>  Komagataella phaffii

<400>  47
atgaccgata cgaaagccgt agaatttgtg ggccacacag ccattgtagt ctttggagct       60

tcaggggacc tggctaagaa gaagactttc cctgccctct tcggacttta ccgtgaggga      120

tacctgtcca acaaggtgaa gattattggc tatgctagat caaagctgga tgacaaggag      180

ttcaaggata gaattgtggg ctatttcaag acaaagaaca agggcgacga ggacaaagtt      240

caagaattct taaagttgtg ctcatatatt tcagctcctt atgacaaacc agatgggtat      300

gaaaagttga atgaaactat taacgaattc gaaaaggaaa acaacgtcga acagtctcac      360

aggttgttct acttagcttt gcccccttct gttttcatac ctgttgctac ggaggtcaag      420

aagtatgttc atccaggttc taaagggatt gctcggatta tcgtggaaaa acctttcggg      480

cacgacttgc agtcagcaga agagcttttg aatgctttga agccgatctg gaaagaagag      540

gaattgttta gaatcgacca ctatctaggt aaggagatgg ttaagaattt gttggccttc      600

cgttttggaa acgcattcat caatgcttct tgggacaaca gacatatcag ctgtatccaa      660

atctcgttca aggagccttt tggaacagaa ggtcgtggtg gctattttga ctcaattggt      720

ataataagag acgtcattca gaaccacttg cttcaagtgt taaccctctt aaccatggag      780

agacccgtct ctaatgaccc tgaggctgtt agagatgaaa aggttcgcat tctgaagtca      840

atttctgagc tagatttgaa cgacgttttg gtgggtcaat acggcaaatc tgaggatgga      900

aagaagccag cttatgtgga tgatgaaact gttaagccag gttctaaatg tgtcacattt      960

gcagccattg gcttgcacat caacacagaa aggtgggaag gtgtcccaat cattttaaga     1020

gctggtaagg ctttgaacga aggtaaagtt gagattagag tgcaatacaa acagtctact     1080

ggatttctca atgatattca gcgaaatgaa ttggtcatcc gtgtgcagcc taacgaagcc     1140

atgtacatga aactgaactc caaagtccca ggtgtttccc aaaagactac tgtcactgag     1200

ctagacctca cttacaaaga ccgttacgaa aacttttaca ttccagaggc atatgaatca     1260

cttatcagag atgctatgaa gggagatcac tctaattttg tcagagatga cgagttgata     1320

caaagttgga agattttcac tcctttactg tatcacttgg agggccctga tgcaccggct     1380

ccagaaatct atccctacgg atccagaggt ccagcttcat tgaccaaatt cttgcaagat     1440

catgattact tctttgaatc acgcgacaat taccaatggc cagtgacaag acccgatgtg     1500

ctgcacaaga tgtaa                                                      1515


<210>  48
<211>  504
<212>  PRT
<213>  Komagataella phaffii

<400>  48

Met Thr Asp Thr Lys Ala Val Glu Phe Val Gly His Thr Ala Ile Val 
1               5                   10                  15      


Val Phe Gly Ala Ser Gly Asp Leu Ala Lys Lys Lys Thr Phe Pro Ala 
            20                  25                  30          


Leu Phe Gly Leu Tyr Arg Glu Gly Tyr Leu Ser Asn Lys Val Lys Ile 
        35                  40                  45              


Ile Gly Tyr Ala Arg Ser Lys Leu Asp Asp Lys Glu Phe Lys Asp Arg 
    50                  55                  60                  


Ile Val Gly Tyr Phe Lys Thr Lys Asn Lys Gly Asp Glu Asp Lys Val 
65                  70                  75                  80  


Gln Glu Phe Leu Lys Leu Cys Ser Tyr Ile Ser Ala Pro Tyr Asp Lys 
                85                  90                  95      


Pro Asp Gly Tyr Glu Lys Leu Asn Glu Thr Ile Asn Glu Phe Glu Lys 
            100                 105                 110         


Glu Asn Asn Val Glu Gln Ser His Arg Leu Phe Tyr Leu Ala Leu Pro 
        115                 120                 125             


Pro Ser Val Phe Ile Pro Val Ala Thr Glu Val Lys Lys Tyr Val His 
    130                 135                 140                 


Pro Gly Ser Lys Gly Ile Ala Arg Ile Ile Val Glu Lys Pro Phe Gly 
145                 150                 155                 160 


His Asp Leu Gln Ser Ala Glu Glu Leu Leu Asn Ala Leu Lys Pro Ile 
                165                 170                 175     


Trp Lys Glu Glu Glu Leu Phe Arg Ile Asp His Tyr Leu Gly Lys Glu 
            180                 185                 190         


Met Val Lys Asn Leu Leu Ala Phe Arg Phe Gly Asn Ala Phe Ile Asn 
        195                 200                 205             


Ala Ser Trp Asp Asn Arg His Ile Ser Cys Ile Gln Ile Ser Phe Lys 
    210                 215                 220                 


Glu Pro Phe Gly Thr Glu Gly Arg Gly Gly Tyr Phe Asp Ser Ile Gly 
225                 230                 235                 240 


Ile Ile Arg Asp Val Ile Gln Asn His Leu Leu Gln Val Leu Thr Leu 
                245                 250                 255     


Leu Thr Met Glu Arg Pro Val Ser Asn Asp Pro Glu Ala Val Arg Asp 
            260                 265                 270         


Glu Lys Val Arg Ile Leu Lys Ser Ile Ser Glu Leu Asp Leu Asn Asp 
        275                 280                 285             


Val Leu Val Gly Gln Tyr Gly Lys Ser Glu Asp Gly Lys Lys Pro Ala 
    290                 295                 300                 


Tyr Val Asp Asp Glu Thr Val Lys Pro Gly Ser Lys Cys Val Thr Phe 
305                 310                 315                 320 


Ala Ala Ile Gly Leu His Ile Asn Thr Glu Arg Trp Glu Gly Val Pro 
                325                 330                 335     


Ile Ile Leu Arg Ala Gly Lys Ala Leu Asn Glu Gly Lys Val Glu Ile 
            340                 345                 350         


Arg Val Gln Tyr Lys Gln Ser Thr Gly Phe Leu Asn Asp Ile Gln Arg 
        355                 360                 365             


Asn Glu Leu Val Ile Arg Val Gln Pro Asn Glu Ala Met Tyr Met Lys 
    370                 375                 380                 


Leu Asn Ser Lys Val Pro Gly Val Ser Gln Lys Thr Thr Val Thr Glu 
385                 390                 395                 400 


Leu Asp Leu Thr Tyr Lys Asp Arg Tyr Glu Asn Phe Tyr Ile Pro Glu 
                405                 410                 415     


Ala Tyr Glu Ser Leu Ile Arg Asp Ala Met Lys Gly Asp His Ser Asn 
            420                 425                 430         


Phe Val Arg Asp Asp Glu Leu Ile Gln Ser Trp Lys Ile Phe Thr Pro 
        435                 440                 445             


Leu Leu Tyr His Leu Glu Gly Pro Asp Ala Pro Ala Pro Glu Ile Tyr 
    450                 455                 460                 


Pro Tyr Gly Ser Arg Gly Pro Ala Ser Leu Thr Lys Phe Leu Gln Asp 
465                 470                 475                 480 


His Asp Tyr Phe Phe Glu Ser Arg Asp Asn Tyr Gln Trp Pro Val Thr 
                485                 490                 495     


Arg Pro Asp Val Leu His Lys Met 
            500                 


<210>  49
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  49
aatcaattga acaactatcg aaacgatgag tgaaggcccc gtcaaat                     47


<210>  50
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  50
aacagtcatg tctaaggcta caaacctaat tatccttcgt atcttctggc                  50


<210>  51
<211>  1029
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  51
atgggtaaaa agcctgaact caccgcgacg tctgtcgaga agtttctgat cgaaaagttc       60

gacagcgtct ccgacctgat gcagctctcg gagggcgaag aatctcgtgc tttcagcttc      120

gatgtaggag ggcgtggata tgtcctgcgg gtaaatagct gcgccgatgg tttctacaaa      180

gatcgttatg tttatcggca ctttgcatcg gccgcgctcc cgattccgga agtgcttgac      240

attggggaat tcagcgagag cctgacctat tgcatctccc gccgtgcaca gggtgtcacg      300

ttgcaagacc tgcctgaaac cgaactgccc gctgttctgc agccggtcgc ggaggccatg      360

gatgcgatcg ctgcggccga tcttagccag acgagcgggt tcggcccatt cggaccgcaa      420

ggaatcggtc aatacactac atggcgtgat ttcatatgcg cgattgctga tccccatgtg      480

tatcactggc aaactgtgat ggacgacacc gtcagtgcgt ccgtcgcgca ggctctcgat      540

gagctgatgc tttgggccga ggactgcccc gaagtccggc acctcgtgca cgcggatttc      600

ggctccaaca atgtcctgac ggacaatggc cgcataacag cggtcattga ctggagcgag      660

gcgatgttcg gggattccca atacgaggtc gccaacatct tcttctggag gccgtggttg      720

gcttgtatgg agcagcagac gcgctacttc gagcggaggc atccggagct tgcaggatcg      780

ccgcgactcc gggcgtatat gctccgcatt ggtcttgacc aactctatca gagcttggtt      840

gacggcaatt tcgatgatgc agcttgggcg cagggtcgat gcgacgcaat cgtccgatcc      900

ggagccggga ctgtcgggcg tacacaaatc gcccgcagaa gcgcggccgt ctggaccgat      960

ggctgtgtag aagtactcgc cgatagtgga aaccgacgcc ccagcactcg tccgagggca     1020

aaggaataa                                                             1029


<210>  52
<211>  342
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  52

Met Gly Lys Lys Pro Glu Leu Thr Ala Thr Ser Val Glu Lys Phe Leu 
1               5                   10                  15      


Ile Glu Lys Phe Asp Ser Val Ser Asp Leu Met Gln Leu Ser Glu Gly 
            20                  25                  30          


Glu Glu Ser Arg Ala Phe Ser Phe Asp Val Gly Gly Arg Gly Tyr Val 
        35                  40                  45              


Leu Arg Val Asn Ser Cys Ala Asp Gly Phe Tyr Lys Asp Arg Tyr Val 
    50                  55                  60                  


Tyr Arg His Phe Ala Ser Ala Ala Leu Pro Ile Pro Glu Val Leu Asp 
65                  70                  75                  80  


Ile Gly Glu Phe Ser Glu Ser Leu Thr Tyr Cys Ile Ser Arg Arg Ala 
                85                  90                  95      


Gln Gly Val Thr Leu Gln Asp Leu Pro Glu Thr Glu Leu Pro Ala Val 
            100                 105                 110         


Leu Gln Pro Val Ala Glu Ala Met Asp Ala Ile Ala Ala Ala Asp Leu 
        115                 120                 125             


Ser Gln Thr Ser Gly Phe Gly Pro Phe Gly Pro Gln Gly Ile Gly Gln 
    130                 135                 140                 


Tyr Thr Thr Trp Arg Asp Phe Ile Cys Ala Ile Ala Asp Pro His Val 
145                 150                 155                 160 


Tyr His Trp Gln Thr Val Met Asp Asp Thr Val Ser Ala Ser Val Ala 
                165                 170                 175     


Gln Ala Leu Asp Glu Leu Met Leu Trp Ala Glu Asp Cys Pro Glu Val 
            180                 185                 190         


Arg His Leu Val His Ala Asp Phe Gly Ser Asn Asn Val Leu Thr Asp 
        195                 200                 205             


Asn Gly Arg Ile Thr Ala Val Ile Asp Trp Ser Glu Ala Met Phe Gly 
    210                 215                 220                 


Asp Ser Gln Tyr Glu Val Ala Asn Ile Phe Phe Trp Arg Pro Trp Leu 
225                 230                 235                 240 


Ala Cys Met Glu Gln Gln Thr Arg Tyr Phe Glu Arg Arg His Pro Glu 
                245                 250                 255     


Leu Ala Gly Ser Pro Arg Leu Arg Ala Tyr Met Leu Arg Ile Gly Leu 
            260                 265                 270         


Asp Gln Leu Tyr Gln Ser Leu Val Asp Gly Asn Phe Asp Asp Ala Ala 
        275                 280                 285             


Trp Ala Gln Gly Arg Cys Asp Ala Ile Val Arg Ser Gly Ala Gly Thr 
    290                 295                 300                 


Val Gly Arg Thr Gln Ile Ala Arg Arg Ser Ala Ala Val Trp Thr Asp 
305                 310                 315                 320 


Gly Cys Val Glu Val Leu Ala Asp Ser Gly Asn Arg Arg Pro Ser Thr 
                325                 330                 335     


Arg Pro Arg Ala Lys Glu 
            340         


<210>  53
<211>  48
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  53
atacgacaag gtgaggaact aaaccatggg taaaaagcct gaactcac                    48


<210>  54
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial sequence

<400>  54
gacccgtggg ccgccgtcgg acgtgttatt cctttgccct cggacg                      46


<210>  55
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC with tags

<400>  55
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcacgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggtccggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  56
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_L92Q

<400>  56
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcacgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga ccagagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggtccggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  57
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_W96A

<400>  57
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcacgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gaggcggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggtccggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  58
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_D119P

<400>  58
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcacgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gccccgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggtccggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  59
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P

<400>  59
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcccgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggtccggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  60
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_S173H

<400>  60
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcacgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggcacggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  61
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P_S173H

<400>  61
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcccgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga cctgagcgag gagtgggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gcgacgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggcacggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  62
<211>  761
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MxSafC_M5

<400>  62
gcagcagcca tcatcatcat catcacagca gcggcctggt gccgcgcggc agccatatgg       60

ctagcatgac tggtggacag caaatgggtc gcggatccat gatccaccac gtcgaattga      120

cacagtccgt cctgcagtac atccgcgaca gttccgtgag ggacaacgac atccttcgcg      180

acctgcgaga ggagacgtcg aagctccccc tgcgcccgat gcagattcct cccgagcagg      240

ggcagctcct gagcctgctg gtgcgcctca tcggcgcgcg caagacgctc gaggtgggcg      300

tcttcaccgg ctatagcacc ctgtgtgccg cgctcgcgct gcccgccgat gggcgcgtca      360

tcgcgtgcga ccagagcgag gaggcggtct ccatcgcgcg ccgctactgg cagcgggcgg      420

gcgtggcgga tcgcatcgag gtccggcttg gccccgccca ccattccctg gaggcgctgg      480

tcggcagcga gcaccgcggg acgttcgacc tcgcgttcat cgatgcggac aaggagagct      540

acgacttcta ctacgagcac gcgctgcggc tggtgcgtcc cggcgggttg atcatcctcg      600

acaacacgct gtggcacggg aaggtcgccg acccgagcgt cgtcggggac ccggagacgg      660

actcgctgcg gcgcatcaac gccaagctcc tgactgacga acgggtggac ctcagcatgc      720

tcccaatcgc tgacggactg accctcgctc gcaagcgcta g                          761


<210>  63
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_L92Q with tags

<400>  63

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Gln Ser Glu Glu Trp 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  64
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_W96A with tags

<400>  64

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Ala 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  65
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_D119P with tags

<400>  65

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Pro Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  66
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P with tags

<400>  66

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  67
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_S173H with tags

<400>  67

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  68
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P_S173H with tags

<400>  68

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  69
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_M5 with tags

<400>  69

Ser Ser His His His His His His Ser Ser Gly Leu Val Pro Arg Gly 
1               5                   10                  15      


Ser His Met Ala Ser Met Thr Gly Gly Gln Gln Met Gly Arg Gly Ser 
            20                  25                  30          


Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
        35                  40                  45              


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
    50                  55                  60                  


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
65                  70                  75                  80  


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
                85                  90                  95      


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
            100                 105                 110         


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Gln Ser Glu Glu Ala 
        115                 120                 125             


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
    130                 135                 140                 


Ile Glu Val Arg Leu Gly Pro Ala His His Ser Leu Glu Ala Leu Val 
145                 150                 155                 160 


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
                165                 170                 175     


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
            180                 185                 190         


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
        195                 200                 205             


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
    210                 215                 220                 


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
225                 230                 235                 240 


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
                245                 250         


<210>  70
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_L92Q

<400>  70

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Gln Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  71
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_W96A

<400>  71

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Ala 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  72
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_D119P

<400>  72

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Pro Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  73
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P

<400>  73

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp Ser Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  74
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_S173H

<400>  74

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Thr Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  75
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_T40P_S173H

<400>  75

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Leu Ser Glu Glu Trp 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Asp Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


<210>  76
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MxSafC_M5

<400>  76

Met Ile His His Val Glu Leu Thr Gln Ser Val Leu Gln Tyr Ile Arg 
1               5                   10                  15      


Asp Ser Ser Val Arg Asp Asn Asp Ile Leu Arg Asp Leu Arg Glu Glu 
            20                  25                  30          


Thr Ser Lys Leu Pro Leu Arg Pro Met Gln Ile Pro Pro Glu Gln Gly 
        35                  40                  45              


Gln Leu Leu Ser Leu Leu Val Arg Leu Ile Gly Ala Arg Lys Thr Leu 
    50                  55                  60                  


Glu Val Gly Val Phe Thr Gly Tyr Ser Thr Leu Cys Ala Ala Leu Ala 
65                  70                  75                  80  


Leu Pro Ala Asp Gly Arg Val Ile Ala Cys Asp Gln Ser Glu Glu Ala 
                85                  90                  95      


Val Ser Ile Ala Arg Arg Tyr Trp Gln Arg Ala Gly Val Ala Asp Arg 
            100                 105                 110         


Ile Glu Val Arg Leu Gly Pro Ala His His Ser Leu Glu Ala Leu Val 
        115                 120                 125             


Gly Ser Glu His Arg Gly Thr Phe Asp Leu Ala Phe Ile Asp Ala Asp 
    130                 135                 140                 


Lys Glu Ser Tyr Asp Phe Tyr Tyr Glu His Ala Leu Arg Leu Val Arg 
145                 150                 155                 160 


Pro Gly Gly Leu Ile Ile Leu Asp Asn Thr Leu Trp His Gly Lys Val 
                165                 170                 175     


Ala Asp Pro Ser Val Val Gly Asp Pro Glu Thr Asp Ser Leu Arg Arg 
            180                 185                 190         


Ile Asn Ala Lys Leu Leu Thr Asp Glu Arg Val Asp Leu Ser Met Leu 
        195                 200                 205             


Pro Ile Ala Asp Gly Leu Thr Leu Ala Arg Lys Arg 
    210                 215                 220 


