                         SEQUENCE LISTING

<110>  GlaxoSmithKline Intellectual Property Development Limited
 
<120>  ANTIGEN BINDING PROTEINS

<130>  PU66651

<150>  US 63/057508
<151>  2020-07-28


<150>  US 62/906876
<151>  2019-09-27

<160>  180   

<170>  PatentIn version 3.5

<210>  1
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-1 variable light chain amino acid sequence

<400>  1

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  2
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-1 variable heavy chain amino acid sequence

<400>  2

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-1 variable light chain nucleic acid sequence

<400>  3
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  4
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-1 variable heavy chain nucleic acid sequence

<400>  4
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc agctacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcac cgccagctac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  5
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-3 variable light chain amino acid sequence

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-3 variable heavy chain amino acid sequence

<400>  6

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Tyr Asn 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Met Gly Thr Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  7
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-3 variable light chain nucleic acid sequence

<400>  7
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  8
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-3 variable heavy chain nucleic acid sequence

<400>  8
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc tacaacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttatgggcac cgccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  9
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-4 variable light chain amino acid sequence

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-4 variable heavy chain amino acid sequence

<400>  10

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Glu Ser Glu 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  11
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-4 variable light chain nucleic acid sequence

<400>  11
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  12
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-4 variable heavy chain nucleic acid sequence

<400>  12
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcgag agcgaggcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcag ggccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  13
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-5 variable light chain amino acid sequence

<400>  13

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  14
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-5 variable heavy chain amino acid sequence

<400>  14

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Arg Gly Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  15
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-5 variable light chain nucleic acid sequence

<400>  15
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  16
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-5 variable heavy chain nucleic acid sequence

<400>  16
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc agccacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcag gggcaagtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  17
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-6 variable light chain amino acid sequence

<400>  17

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  18
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-6 variable heavy chain amino acid sequence

<400>  18

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly His 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  19
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-6 variable light chain nucleic acid sequence

<400>  19
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  20
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-6 variable heavy chain nucleic acid sequence

<400>  20
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc ggccacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcag ggccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  21
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-18 variable light chain amino acid sequence

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-18 variable heavy chain amino acid sequence

<400>  22

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Arg 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Met Gly Thr Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  23
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-18 variable light chain nucleic acid sequence

<400>  23
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  24
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-18 variable heavy chain nucleic acid sequence

<400>  24
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc agcagggcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttatgggcac cgccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  25
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-33 variable light chain amino acid sequence

<400>  25

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  26
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-33 variable heavy chain amino acid sequence

<400>  26

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Leu Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  27
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-33 variable light chain nucleic acid sequence

<400>  27
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  28
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-33 variable heavy chain nucleic acid sequence

<400>  28
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc agctacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcctgccca ttttcggcag ggccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  29
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-88 variable light chain amino acid sequence

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  30
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-88 variable heavy chain amino acid sequence

<400>  30

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Ser 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  31
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-88 variable light chain nucleic acid sequence

<400>  31
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  32
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-88 variable heavy chain nucleic acid sequence

<400>  32
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc agcagcgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcag ggccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  33
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-3 variable light chain amino acid sequence

<400>  33

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  34
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-3 variable heavy chain amino acid sequence

<400>  34

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Val Asn Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  35
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-3 variable light chain nucleic acid sequence

<400>  35
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  36
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-3 variable heavy chain nucleic acid sequence

<400>  36
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcgtg aactacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatccccg ccctgggcac cgccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  37
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-4 variable light chain amino acid sequence

<400>  37

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  38
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-4 variable heavy chain amino acid sequence

<400>  38

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Glu Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Ile Pro Ile Phe Gly Thr Ala Gly Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  39
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-4 variable light chain nucleic acid sequence

<400>  39
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  40
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-4 variable heavy chain nucleic acid sequence

<400>  40
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc gagtacgcca tccactgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcaac atcatcccca ttttcggcac cgccggctac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  41
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-8 variable light chain amino acid sequence

<400>  41

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  42
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-8 variable heavy chain amino acid sequence

<400>  42

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Trp Leu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Gln Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  43
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-8 variable light chain nucleic acid sequence

<400>  43
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  44
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-8 variable heavy chain nucleic acid sequence

<400>  44
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttctgg ctgtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatccccc agctgggcac cgccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  45
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-17 variable light chain amino acid sequence

<400>  45

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  46
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-17 variable heavy chain amino acid sequence

<400>  46

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Arg Glu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Val Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  47
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-17 variable light chain nucleic acid sequence

<400>  47
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  48
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-17 variable heavy chain nucleic acid sequence

<400>  48
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagg gagtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatccccg tgttcggcac cgccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  49
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-22 variable light chain amino acid sequence

<400>  49

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  50
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-22 variable heavy chain amino acid sequence

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asp Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Phe Gly Thr Ala Trp Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  51
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-22 variable light chain nucleic acid sequence

<400>  51
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  52
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-22 variable heavy chain nucleic acid sequence

<400>  52
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcgccag cgtgaaggtg       60

agctgcaagg cctccggcta caccttcgac agctacgcca tgcactgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttttcggcac cgcctggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  53
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-47 variable light chain amino acid sequence

<400>  53

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  54
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-47 variable heavy chain amino acid sequence

<400>  54

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gln Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Val Ile Ile Pro Ile Phe Gly Lys Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  55
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-47 variable light chain nucleic acid sequence

<400>  55
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  56
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-47 variable heavy chain nucleic acid sequence

<400>  56
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc cagtacgcca tccactgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcgtg atcatcccca ttttcggcaa ggccaactac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  57
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-2B04-46 variable light chain amino acid sequence

<400>  57

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Lys Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Asp Asn Trp Pro Ile 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-2B04-46 variable heavy chain amino acid sequence

<400>  58

Gln Val Gln Leu Gln Gln Trp Gly Ala Gly Leu Leu Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Val Tyr Gly Gly Ser Phe Arg Arg Tyr 
            20                  25                  30          


Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Gly Trp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Gly Ser Val Asp Phe Trp Ser Gly Ser Asp Tyr Tyr Tyr Tyr 
            100                 105                 110         


Met Asp Val Trp Gly Lys Gly Ala Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  59
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-2B04-46 variable light chain nucleic acid sequence

<400>  59
gagatcgtgc tgacccagag ccccgcaacc ctgtccctga gccccggcga aagggccact       60

ctgagctgca gggccagcca gagcgtgagc agctacctcg cctggtacca gcagaagccc      120

ggccaggccc ctaggctgct gatctacgac gccagcaaga gggccaccgg cattcccgcc      180

aggttcagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctggagccc      240

gaggacttcg ccgtctacta ctgccagcag ctggacaact ggcccatcac cttcgggggc      300

ggcaccaagg tggagatcaa g                                                321


<210>  60
<211>  377
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-2B04-46 variable heavy chain nucleic acid sequence

<400>  60
caggtgcagc tgcagcagtg gggcgccgga ctgctgaagc ccagcgagac cctgagcctg       60

acctgcgccg tgtacggcgg gtccttcagg aggtactact ggagctggat caggcagccc      120

cccggcaaag gcctggagtg gatcggcgag atcgacggct ggggcagcac caactacaac      180

cccagcctca agagcagggt gaccatcagc gtggacacca gcaagaacca gttcagcctg      240

aagctgagca gcgtgaccgc cgccgacacc gccgtgtact attgcgccag gggcggcagc      300

gtggacttct ggagcggcag cgactactac tactacatgg acgtgtgggg caagggcgcc      360

accgtcaccg tgagcag                                                     377


<210>  61
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-85 variable light chain amino acid sequence

<400>  61

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  62
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-85 variable heavy chain amino acid sequence

<400>  62

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Pro Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Phe Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  63
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-85 variable light chain nucleic acid sequence

<400>  63
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  64
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-85 variable heavy chain nucleic acid sequence

<400>  64
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc agctacccca tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggcatc atcaacccca gcggaggctt caccagctac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagcgcc                                                              369


<210>  65
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-97 variable light chain amino acid sequence

<400>  65

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  66
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-97 variable heavy chain amino acid sequence

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Ala 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ala Gly Gly Tyr Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  67
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-97 variable light chain nucleic acid sequence

<400>  67
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  68
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-97 variable heavy chain nucleic acid sequence

<400>  68
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc agggccgcca tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggcatc atcaaccccg ccggaggcta caccagctac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagctct                                                              369


<210>  69
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-100 variable light chain amino acid sequence

<400>  69

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  70
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-100 variable heavy chain amino acid sequence

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Thr Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ser Gly Gly Leu Thr Gln Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  71
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-100 variable light chain nucleic acid sequence

<400>  71
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  72
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-100 variable heavy chain nucleic acid sequence

<400>  72
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc acctacagga tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggcatc atcaacccca gcggaggcct gacccagtac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagctct                                                              369


<210>  73
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-103 variable light chain amino acid sequence

<400>  73

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  74
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-103 variable heavy chain amino acid sequence

<400>  74

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Ala Gly Gly Trp Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  75
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-103 variable light chain nucleic acid sequence

<400>  75
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  76
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-103 variable heavy chain nucleic acid sequence

<400>  76
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc gcctaccaga tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggcatc atcaaccccg ccggaggctg gaccagctac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagctct                                                              369


<210>  77
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-126 variable light chain amino acid sequence

<400>  77

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  78
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-126 variable heavy chain amino acid sequence

<400>  78

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Arg Tyr 
            20                  25                  30          


Asn Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Ala Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  79
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-126 variable light chain nucleic acid sequence

<400>  79
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  80
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-126 variable heavy chain nucleic acid sequence

<400>  80
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc aggtacaaca tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggctgg atcaaccccg ccggaggcag caccagctac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagcgcc                                                              369


<210>  81
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-191 variable light chain amino acid sequence

<400>  81

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Leu Tyr Pro Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  82
<211>  123
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-1A01-191 variable heavy chain amino acid sequence

<400>  82

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Lys Tyr 
            20                  25                  30          


Arg Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Ile Ile Asn Pro Gln Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120             


<210>  83
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-191 variable light chain nucleic acid sequence

<400>  83
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag agcctgtacc cccccaggac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  84
<211>  369
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-1A01-191 variable heavy chain nucleic acid sequence

<400>  84
caggtgcagc tggtgcagag cggcgccgaa gtgaaaaagc ccggcgccag cgtgaaggtc       60

agctgcaagg cctccgggta caccttcacc aagtacagga tgcactgggt gaggcaggcc      120

cccggccagg gcctcgagtg gatgggcatc atcaaccccc agggaggcag caccagctac      180

gcccagaagt tccagggcag ggtgaccatg acaagggaca ccagcaccag caccgtgtac      240

atggagctga gcagcctgag gagcgaggac accgccgtgt attactgcgc aagggagacc      300

gcctactaca ccaccaaggg caactggttc gacccctggg gccagggcac cctggtgacc      360

gtgagcgcc                                                              369


<210>  85
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-66 variable light chain amino acid sequence

<400>  85

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  86
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-66 variable heavy chain amino acid sequence

<400>  86

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Val Glu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Gln Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  87
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-66 variable light chain nucleic acid sequence

<400>  87
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  88
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-66 variable heavy chain nucleic acid sequence

<400>  88
caggtgcagc tggtgcagag cggcgcagag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcgtg gagtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatccccg ccttcggcac cgcccagtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggagcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  89
<211>  106
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-16 variable light chain amino acid sequence

<400>  89

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105     


<210>  90
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-16 variable heavy chain amino acid sequence

<400>  90

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Glu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Val Phe Gly Thr Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  91
<211>  318
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-16 variable light chain nucleic acid sequence

<400>  91
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaag                                                    318


<210>  92
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-16 variable heavy chain nucleic acid sequence

<400>  92
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcaac gagtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcgtgcccg tgttcggcac cgccaagtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagc                                                                 366


<210>  93
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-23 variable light chain amino acid sequence

<400>  93

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  94
<211>  118
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-23 variable heavy chain amino acid sequence

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Met Gly Thr Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser 
        115             


<210>  95
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-23 variable light chain nucleic acid sequence

<400>  95
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa g                                                321


<210>  96
<211>  354
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-23 variable heavy chain nucleic acid sequence

<400>  96
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc ggctacccca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttatgggcac cgccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagc            354


<210>  97
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 amino acid sequence 1

<400>  97

Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 
1               5                   10      


<210>  98
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL1 amino acid sequence 2

<400>  98

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  99
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  

CDRL2 amino acid sequence 1

<400>  99

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  100
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL2 amino acid sequence 2

<400>  100

Asp Ala Ser Lys Arg Ala Thr 
1               5           


<210>  101
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 amino acid sequence 1

<400>  101

Gln Gln Val Leu His Thr Ile Thr 
1               5               


<210>  102
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 amino acid sequence 2

<400>  102

Gln Gln Pro Tyr Phe Ser Pro Pro Thr 
1               5                   


<210>  103
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 amino acid sequence 3

<400>  103

Gln Gln Leu Asp Asn Trp Pro Ile Thr 
1               5                   


<210>  104
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRL3 amino acid sequence 4

<400>  104

Gln Gln Ser Leu Tyr Pro Pro Arg Thr 
1               5                   


<210>  105
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 1

<400>  105

Ser Tyr Ala Ile Ser 
1               5   


<210>  106
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 2

<400>  106

Tyr Asn Ala Ile Ser 
1               5   


<210>  107
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 3

<400>  107

Ser Glu Ala Ile Ser 
1               5   


<210>  108
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 4

<400>  108

Ser His Ala Ile Ser 
1               5   


<210>  109
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 5

<400>  109

Gly His Ala Ile Ser 
1               5   


<210>  110
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 6

<400>  110

Ser Arg Ala Ile Ser 
1               5   


<210>  111
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 7

<400>  111

Ser Ser Ala Ile Ser 
1               5   


<210>  112
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 8

<400>  112

Asn Tyr Ala Ile Ser 
1               5   


<210>  113
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 9

<400>  113

Glu Tyr Ala Ile His 
1               5   


<210>  114
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 10

<400>  114

Leu Tyr Ala Ile Ser 
1               5   


<210>  115
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 11

<400>  115

Glu Tyr Ala Ile Ser 
1               5   


<210>  116
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 12

<400>  116

Ser Tyr Ala Met His 
1               5   


<210>  117
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 13

<400>  117

Gln Tyr Ala Ile His 
1               5   


<210>  118
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 14

<400>  118

Arg Tyr Tyr Trp Ser 
1               5   


<210>  119
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 15

<400>  119

Ser Tyr Pro Met His 
1               5   


<210>  120
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 16

<400>  120

Arg Ala Ala Met His 
1               5   


<210>  121
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 17

<400>  121

Thr Tyr Arg Met His 
1               5   


<210>  122
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 18

<400>  122

Ala Tyr Gln Met His 
1               5   


<210>  123
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 19

<400>  123

Arg Tyr Asn Met His 
1               5   


<210>  124
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 20

<400>  124

Lys Tyr Arg Met His 
1               5   


<210>  125
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH1 amino acid sequence 21

<400>  125

Gly Tyr Pro Ile Ser 
1               5   


<210>  126
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 1

<400>  126

Gly Ile Ile Pro Ile Phe Gly Thr Ala Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  127
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 2

<400>  127

Gly Ile Ile Pro Ile Met Gly Thr Ala Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  128
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 3

<400>  128

Gly Ile Ile Pro Ile Phe Gly Arg Ala Arg Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  129
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 4

<400>  129

Gly Ile Ile Pro Ile Phe Gly Arg Gly Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  130
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 5

<400>  130

Gly Ile Leu Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  131
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 6

<400>  131

Gly Ile Ile Pro Ile Phe Gly Arg Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  132
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 7

<400>  132

Gly Ile Ile Pro Ala Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  133
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 8

<400>  133

Asn Ile Ile Pro Ile Phe Gly Thr Ala Gly Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  134
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 9

<400>  134

Gly Ile Ile Pro Gln Leu Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  135
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 10

<400>  135

Gly Ile Ile Pro Val Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  136
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 11

<400>  136

Gly Ile Ile Pro Ile Phe Gly Thr Ala Trp Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  137
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 12

<400>  137

Val Ile Ile Pro Ile Phe Gly Lys Ala Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  138
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 13

<400>  138

Glu Ile Asp Gly Trp Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  139
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 14

<400>  139

Ile Ile Asn Pro Ser Gly Gly Phe Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  140
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 15

<400>  140

Ile Ile Asn Pro Ala Gly Gly Tyr Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  141
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 16

<400>  141

Ile Ile Asn Pro Ser Gly Gly Leu Thr Gln Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  142
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 17

<400>  142

Ile Ile Asn Pro Ala Gly Gly Trp Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  143
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 18

<400>  143

Trp Ile Asn Pro Ala Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  144
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 19

<400>  144

Ile Ile Asn Pro Gln Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  145
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 20

<400>  145

Gly Ile Ile Pro Ala Phe Gly Thr Ala Gln Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  146
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH2 amino acid sequence 21

<400>  146

Gly Ile Val Pro Val Phe Gly Thr Ala Lys Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  147
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 amino acid sequence 1

<400>  147

Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val 
1               5                   10              


<210>  148
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 amino acid sequence 2

<400>  148

Leu Leu Gly Glu Ser Gly Met Asp Val 
1               5                   


<210>  149
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 amino acid sequence 3

<400>  149

Gly Gly Ser Val Asp Phe Trp Ser Gly Ser Asp Tyr Tyr Tyr Tyr Met 
1               5                   10                  15      


Asp Val 
        


<210>  150
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  CDRH3 amino acid sequence 4

<400>  150

Glu Thr Ala Tyr Tyr Thr Thr Lys Gly Asn Trp Phe Asp Pro 
1               5                   10                  


<210>  151
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRH1

<400>  151

Ser Tyr Asp Met Ser 
1               5   


<210>  152
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRH2

<400>  152

Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  153
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRH3

<400>  153

Pro Tyr Tyr Ala Met Asp Tyr 
1               5           


<210>  154
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRL1

<400>  154

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  155
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRL2

<400>  155

Trp Ala Ser Thr Leu His Thr 
1               5           


<210>  156
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist CDRH3

<400>  156

Gln His Tyr Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  157
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist alternative CDRL3

<400>  157

Gln His Tyr Asn Ser Tyr Pro Trp Thr 
1               5                   


<210>  158
<211>  116
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist heavy chain variable region

<400>  158

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  159
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist light chain variable region

<400>  159

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  160
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist monoclonal antibody heavy chain

<400>  160

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  161
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist monoclonal antibody light chain

<400>  161

Asp Ile Gln Leu Thr Gln Ser Pro Ser Phe Leu Ser Ala Tyr Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  162
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist heavy chain sequence with N380D modification

<400>  162

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asp Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  163
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist light chain sequence with N385D modification

<400>  163

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asp Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  164
<211>  443
<212>  PRT
<213>  Artificial

<220>
<223>  PD-1 antagonist heavy chain sequence with N380D and N385D 
       modifications

<400>  164

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Thr Ile Ser Gly Gly Gly Ser Tyr Thr Tyr Tyr Gln Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Pro Tyr Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                165                 170                 175     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            180                 185                 190         


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
        195                 200                 205             


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
    210                 215                 220                 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asp Gly Gln Pro Glu 
    370                 375                 380                 


Asp Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440             


<210>  165
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-66 full length heavy chain amino acid sequence

<400>  165

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Val Glu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ala Phe Gly Thr Ala Gln Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  166
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-66 full length light chain amino acid sequence

<400>  166

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  167
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-66 full length heavy chain DNA sequence

<400>  167
caggtgcagc tggtgcagag cggcgcagag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcgtg gagtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatccccg ccttcggcac cgcccagtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggagcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgtaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgtgacaa gacccacacc tgccccccct gccctgcccc cgagctgctg      720

ggaggcccca gcgtgttcct gttccccccc aagcctaagg acaccctgat gatcagcaga      780

acccccgagg tgacctgtgt ggtggtggat gtgagccacg aggaccctga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcccag ggaggagcag      900

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac      960

ggcaaggagt acaagtgtaa ggtgtccaac aaggccctgc ctgcccctat cgagaaaacc     1020

atcagcaagg ccaagggcca gcccagagag ccccaggtgt acaccctgcc ccctagcaga     1080

gatgagctga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgatgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1260

agatggcagc agggcaacgt gttcagctgc tccgtgatgc acgaggccct gcacaatcac     1320

tacacccaga agagcctgag cctgtcccct ggcaag                               1356


<210>  168
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-66 full length light chain DNA sequence

<400>  168
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaagcg tacggtggcc gcccccagcg tgttcatctt cccccccagc      360

gatgagcagc tgaagagcgg caccgccagc gtggtgtgtc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aatgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgtg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                             639


<210>  169
<211>  213
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-16 full length light chain amino acid sequence

<400>  169

Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Val Leu His Thr Ile Thr 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 
            100                 105                 110         


Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 
        115                 120                 125             


Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140                 


Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 
145                 150                 155                 160 


Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 
            180                 185                 190         


Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 
        195                 200                 205             


Asn Arg Gly Glu Cys 
    210             


<210>  170
<211>  452
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F08-16 full length heavy chain amino acid sequence

<400>  170

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Asn Glu Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Val Pro Val Phe Gly Thr Ala Lys Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Gly Tyr Tyr Gly Asp Lys Asp Pro Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220                 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
225                 230                 235                 240 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
                245                 250                 255     


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
            260                 265                 270         


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
        275                 280                 285             


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
    290                 295                 300                 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
305                 310                 315                 320 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
                325                 330                 335     


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
            340                 345                 350         


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
        355                 360                 365             


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
    370                 375                 380                 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
385                 390                 395                 400 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
                405                 410                 415     


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
            420                 425                 430         


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
        435                 440                 445             


Ser Pro Gly Lys 
    450         


<210>  171
<211>  639
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-16 full length light chain DNA sequence

<400>  171
gacatccagc tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag gtgctgcaca ccatcacttt cggcggcggc      300

accaaggtgg agattaagcg tacggtggcc gcccccagcg tgttcatctt cccccccagc      360

gatgagcagc tgaagagcgg caccgccagc gtggtgtgtc tgctgaacaa cttctacccc      420

cgggaggcca aggtgcagtg gaaggtggac aatgccctgc agagcggcaa cagccaggag      480

agcgtgaccg agcaggacag caaggactcc acctacagcc tgagcagcac cctgaccctg      540

agcaaggccg actacgagaa gcacaaggtg tacgcctgtg aggtgaccca ccagggcctg      600

tccagccccg tgaccaagag cttcaaccgg ggcgagtgc                             639


<210>  172
<211>  1356
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F08-16  full length heavy chain DNA sequence

<400>  172
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcaac gagtacgcca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcgtgcccg tgttcggcac cgccaagtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggggcgcc      300

ggctactacg gcgacaagga ccccatggac gtgtggggcc agggcaccac cgtgactgtg      360

agcagcgcca gcaccaaggg ccccagcgtg ttccccctgg cccccagcag caagagcacc      420

agcggcggca cagccgccct gggctgcctg gtgaaggact acttccccga gcccgtgacc      480

gtgtcctgga acagcggagc cctgaccagc ggcgtgcaca ccttccccgc cgtgctgcag      540

agcagcggcc tgtacagcct gagcagcgtg gtgaccgtgc ccagcagcag cctgggcacc      600

cagacctaca tctgtaacgt gaaccacaag cccagcaaca ccaaggtgga caagaaggtg      660

gagcccaaga gctgtgacaa gacccacacc tgccccccct gccctgcccc cgagctgctg      720

ggaggcccca gcgtgttcct gttccccccc aagcctaagg acaccctgat gatcagcaga      780

acccccgagg tgacctgtgt ggtggtggat gtgagccacg aggaccctga ggtgaagttc      840

aactggtacg tggacggcgt ggaggtgcac aatgccaaga ccaagcccag ggaggagcag      900

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ttggctgaac      960

ggcaaggagt acaagtgtaa ggtgtccaac aaggccctgc ctgcccctat cgagaaaacc     1020

atcagcaagg ccaagggcca gcccagagag ccccaggtgt acaccctgcc ccctagcaga     1080

gatgagctga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc     1140

gacatcgccg tggagtggga gagcaacggc cagcccgaga acaactacaa gaccaccccc     1200

cctgtgctgg acagcgatgg cagcttcttc ctgtacagca agctgaccgt ggacaagagc     1260

agatggcagc agggcaacgt gttcagctgc tccgtgatgc acgaggccct gcacaatcac     1320

tacacccaga agagcctgag cctgtcccct ggcaag                               1356


<210>  173
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-23 full length light chain amino acid sequence

<400>  173

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Pro Tyr Phe Ser Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  174
<211>  448
<212>  PRT
<213>  Artificial

<220>
<223>  42Y073-86F04-23 full length Heavy chain amino acid sequence

<400>  174

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Gly Tyr 
            20                  25                  30          


Pro Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Ile Met Gly Thr Ala Arg Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Leu Gly Glu Ser Gly Met Asp Val Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             


Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  175
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-23 full length Light chain DNA sequence

<400>  175
gacatccaga tgacccagag ccctagcagc ctgagcgcca gcgtgggaga cagggtgacc       60

atcacctgca gggccagcca gtccatcagc agctacctga actggtacca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgcc gcaagctcac tgcagagcgg cgtgccctct      180

aggtttagcg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctccagccc      240

gaggacttcg ccacctacta ctgccagcag ccctacttca gcccccccac tttcggcggc      300

ggcaccaagg tggagattaa gcgtacggtg gccgccccca gcgtgttcat cttccccccc      360

agcgatgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac      420

ccccgggagg ccaaggtgca gtggaaggtg gacaatgccc tgcagagcgg caacagccag      480

gagagcgtga ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc      540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc      600

ctgtccagcc ccgtgaccaa gagcttcaac cggggcgagt gc                         642


<210>  176
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  42Y073-86F04-23  full length Heavy chain DNA sequence

<400>  176
caggtgcagc tggtgcagag cggcgccgag gtgaaaaagc ccggcagcag cgtgaaggtg       60

agctgcaagg cctccggcgg gaccttcagc ggctacccca tcagctgggt gaggcaggct      120

cccggacagg gcctggagtg gatgggcggc atcatcccca ttatgggcac cgccaggtac      180

gcccagaagt tccagggaag ggtcaccatc accgccgacg agagcaccag caccgcctac      240

atggaactca gcagcctgag gagcgaggac accgccgtgt actattgcgc caggctgctg      300

ggcgagagcg gcatggacgt gtggggccag ggcaccaccg tgactgtgag cagcgccagc      360

accaagggcc ccagcgtgtt ccccctggcc cccagcagca agagcaccag cggcggcaca      420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac      480

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg      540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc      600

tgtaacgtga accacaagcc cagcaacacc aaggtggaca agaaggtgga gcccaagagc      660

tgtgacaaga cccacacctg ccccccctgc cctgcccccg agctgctggg aggccccagc      720

gtgttcctgt tcccccccaa gcctaaggac accctgatga tcagcagaac ccccgaggtg      780

acctgtgtgg tggtggatgt gagccacgag gaccctgagg tgaagttcaa ctggtacgtg      840

gacggcgtgg aggtgcacaa tgccaagacc aagcccaggg aggagcagta caacagcacc      900

taccgggtgg tgtccgtgct gaccgtgctg caccaggatt ggctgaacgg caaggagtac      960

aagtgtaagg tgtccaacaa ggccctgcct gcccctatcg agaaaaccat cagcaaggcc     1020

aagggccagc ccagagagcc ccaggtgtac accctgcccc ctagcagaga tgagctgacc     1080

aagaaccagg tgtccctgac ctgcctggtg aagggcttct accccagcga catcgccgtg     1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac     1200

agcgatggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag     1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaatcacta cacccagaag     1320

agcctgagcc tgtcccctgg caag                                            1344


<210>  177
<211>  564
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CD155-fc amino acid sequence used in examples

<400>  177

Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln Ala Pro Thr Gln 
1               5                   10                  15      


Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro Cys Tyr Leu Gln 
            20                  25                  30          


Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu Thr Trp Ala Arg 
        35                  40                  45              


His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln Thr Gln Gly Pro 
    50                  55                  60                  


Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala Ala Arg Leu Gly 
65                  70                  75                  80  


Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly Leu Arg Val Glu 
                85                  90                  95      


Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe Pro Gln Gly Ser 
            100                 105                 110         


Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys Pro Gln Asn Thr 
        115                 120                 125             


Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro Val Pro Met Ala 
    130                 135                 140                 


Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln Ile Thr Trp His 
145                 150                 155                 160 


Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val Pro Gly Phe Leu 
                165                 170                 175     


Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu Val Pro Ser Ser 
            180                 185                 190         


Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu His Glu Ser Phe 
        195                 200                 205             


Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val Tyr Tyr Pro Pro 
    210                 215                 220                 


Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr Leu Gly Gln Asn 
225                 230                 235                 240 


Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro Glu Pro Thr Gly 
                245                 250                 255     


Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro Phe Ala Val Ala 
            260                 265                 270         


Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys Pro Ile Asn Thr 
        275                 280                 285             


Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala Arg Gln Ala Glu 
    290                 295                 300                 


Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu His Ser Gly Ile 
305                 310                 315                 320 


Ser Arg Asn Ser Gly Glu Asn Leu Tyr Phe Gln Gly Asp Pro Lys Ser 
                325                 330                 335     


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            340                 345                 350         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        355                 360                 365             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    370                 375                 380                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
385                 390                 395                 400 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                405                 410                 415     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            420                 425                 430         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        435                 440                 445             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    450                 455                 460                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
465                 470                 475                 480 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                485                 490                 495     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            500                 505                 510         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        515                 520                 525             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    530                 535                 540                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
545                 550                 555                 560 


Ser Pro Gly Lys 
                


<210>  178
<211>  417
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ala Arg Ala Met Ala Ala Ala Trp Pro Leu Leu Leu Val Ala Leu 
1               5                   10                  15      


Leu Val Leu Ser Trp Pro Pro Pro Gly Thr Gly Asp Val Val Val Gln 
            20                  25                  30          


Ala Pro Thr Gln Val Pro Gly Phe Leu Gly Asp Ser Val Thr Leu Pro 
        35                  40                  45              


Cys Tyr Leu Gln Val Pro Asn Met Glu Val Thr His Val Ser Gln Leu 
    50                  55                  60                  


Thr Trp Ala Arg His Gly Glu Ser Gly Ser Met Ala Val Phe His Gln 
65                  70                  75                  80  


Thr Gln Gly Pro Ser Tyr Ser Glu Ser Lys Arg Leu Glu Phe Val Ala 
                85                  90                  95      


Ala Arg Leu Gly Ala Glu Leu Arg Asn Ala Ser Leu Arg Met Phe Gly 
            100                 105                 110         


Leu Arg Val Glu Asp Glu Gly Asn Tyr Thr Cys Leu Phe Val Thr Phe 
        115                 120                 125             


Pro Gln Gly Ser Arg Ser Val Asp Ile Trp Leu Arg Val Leu Ala Lys 
    130                 135                 140                 


Pro Gln Asn Thr Ala Glu Val Gln Lys Val Gln Leu Thr Gly Glu Pro 
145                 150                 155                 160 


Val Pro Met Ala Arg Cys Val Ser Thr Gly Gly Arg Pro Pro Ala Gln 
                165                 170                 175     


Ile Thr Trp His Ser Asp Leu Gly Gly Met Pro Asn Thr Ser Gln Val 
            180                 185                 190         


Pro Gly Phe Leu Ser Gly Thr Val Thr Val Thr Ser Leu Trp Ile Leu 
        195                 200                 205             


Val Pro Ser Ser Gln Val Asp Gly Lys Asn Val Thr Cys Lys Val Glu 
    210                 215                 220                 


His Glu Ser Phe Glu Lys Pro Gln Leu Leu Thr Val Asn Leu Thr Val 
225                 230                 235                 240 


Tyr Tyr Pro Pro Glu Val Ser Ile Ser Gly Tyr Asp Asn Asn Trp Tyr 
                245                 250                 255     


Leu Gly Gln Asn Glu Ala Thr Leu Thr Cys Asp Ala Arg Ser Asn Pro 
            260                 265                 270         


Glu Pro Thr Gly Tyr Asn Trp Ser Thr Thr Met Gly Pro Leu Pro Pro 
        275                 280                 285             


Phe Ala Val Ala Gln Gly Ala Gln Leu Leu Ile Arg Pro Val Asp Lys 
    290                 295                 300                 


Pro Ile Asn Thr Thr Leu Ile Cys Asn Val Thr Asn Ala Leu Gly Ala 
305                 310                 315                 320 


Arg Gln Ala Glu Leu Thr Val Gln Val Lys Glu Gly Pro Pro Ser Glu 
                325                 330                 335     


His Ser Gly Ile Ser Arg Asn Ala Ile Ile Phe Leu Val Leu Gly Ile 
            340                 345                 350         


Leu Val Phe Leu Ile Leu Leu Gly Ile Gly Ile Tyr Phe Tyr Trp Ser 
        355                 360                 365             


Lys Cys Ser Arg Glu Val Leu Trp His Cys His Leu Cys Pro Ser Ser 
    370                 375                 380                 


Thr Glu His Ala Ser Ala Ser Ala Asn Gly His Val Ser Tyr Ser Ala 
385                 390                 395                 400 


Val Ser Arg Glu Asn Ser Ser Ser Gln Asp Pro Gln Thr Glu Gly Thr 
                405                 410                 415     


Arg 
    


<210>  179
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  179

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210>  180
<211>  990
<212>  DNA
<213>  Homo sapiens

<400>  180
gccagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag caccagcggc       60

ggcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgtcc      120

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      180

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcagcctggg cacccagacc      240

tacatctgta acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      300

aagagctgtg acaagaccca cacctgcccc ccctgccctg cccccgagct gctgggaggc      360

cccagcgtgt tcctgttccc ccccaagcct aaggacaccc tgatgatcag cagaaccccc      420

gaggtgacct gtgtggtggt ggatgtgagc cacgaggacc ctgaggtgaa gttcaactgg      480

tacgtggacg gcgtggaggt gcacaatgcc aagaccaagc ccagggagga gcagtacaac      540

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggattggct gaacggcaag      600

gagtacaagt gtaaggtgtc caacaaggcc ctgcctgccc ctatcgagaa aaccatcagc      660

aaggccaagg gccagcccag agagccccag gtgtacaccc tgccccctag cagagatgag      720

ctgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgacatc      780

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccctgtg      840

ctggacagcg atggcagctt cttcctgtac agcaagctga ccgtggacaa gagcagatgg      900

cagcagggca acgtgttcag ctgctccgtg atgcacgagg ccctgcacaa tcactacacc      960

cagaagagcc tgagcctgtc ccctggcaag                                       990


