               SEQUENCE LISTING

<110> Michalakis, Stylianos
      Biel, Martin
      Becirovic, Elvir

<120> METHOD OF TRANSACTIVATING A HOMOLOGOUS GENE OF A GENE OF INTEREST AND AN IN VITRO METHOD OF DIGNOSING A DISEASE

<130> 116897P1314PC

<150> EP20191613.7
<151> 2020-08-18
<150> EP19198830.2
<151> 2019-09-23

<160> 127

<170> BiSSAP 1.3.6

<210> 1
<211> 6786
<212> DNA
<213> Homo sapiens


<400> 1
atggcttgtt ggcctcagct gaggttgctg ctgtggaaga acctcacttt cagaagaaga       60

caaacatgtc agctgctgct ggaagtggcc tggcctctat ttatcttcct gatcctgatc      120

tctgttcggc tgagctaccc accctatgaa caacatgaat gccattttcc aaataaagcc      180

atgccctctg caggaacact tccttgggtt caggggatta tctgtaatgc caacaacccc      240

tgtttccgtt acccgactcc tggggaggct cccggagttg ttggaaactt taacaaatcc      300

attgtggctc gcctgttctc agatgctcgg aggcttcttt tatacagcca gaaagacacc      360

agcatgaagg acatgcgcaa agttctgaga acattacagc agatcaagaa atccagctca      420

aacttgaagc ttcaagattt cctggtggac aatgaaacct tctctgggtt cctgtatcac      480

aacctctctc tcccaaagtc tactgtggac aagatgctga gggctgatgt cattctccac      540

aaggtatttt tgcaaggcta ccagttacat ttgacaagtc tgtgcaatgg atcaaaatca      600

gaagagatga ttcaacttgg tgaccaagaa gtttctgagc tttgtggcct accaagggag      660

aaactggctg cagcagagcg agtacttcgt tccaacatgg acatcctgaa gccaatcctg      720

agaacactaa actctacatc tcccttcccg agcaaggagc tggctgaagc cacaaaaaca      780

ttgctgcata gtcttgggac tctggcccag gagctgttca gcatgagaag ctggagtgac      840

atgcgacagg aggtgatgtt tctgaccaat gtgaacagct ccagctcctc cacccaaatc      900

taccaggctg tgtctcgtat tgtctgcggg catcccgagg gaggggggct gaagatcaag      960

tctctcaact ggtatgagga caacaactac aaagccctct ttggaggcaa tggcactgag     1020

gaagatgctg aaaccttcta tgacaactct acaactcctt actgcaatga tttgatgaag     1080

aatttggagt ctagtcctct ttcccgcatt atctggaaag ctctgaagcc gctgctcgtt     1140

gggaagatcc tgtatacacc tgacactcca gccacaaggc aggtcatggc tgaggtgaac     1200

aagaccttcc aggaactggc tgtgttccat gatctggaag gcatgtggga ggaactcagc     1260

cccaagatct ggaccttcat ggagaacagc caagaaatgg accttgtccg gatgctgttg     1320

gacagcaggg acaatgacca cttttgggaa cagcagttgg atggcttaga ttggacagcc     1380

caagacatcg tggcgttttt ggccaagcac ccagaggatg tccagtccag taatggttct     1440

gtgtacacct ggagagaagc tttcaacgag actaaccagg caatccggac catatctcgc     1500

ttcatggagt gtgtcaacct gaacaagcta gaacccatag caacagaagt ctggctcatc     1560

aacaagtcca tggagctgct ggatgagagg aagttctggg ctggtattgt gttcactgga     1620

attactccag gcagcattga gctgccccat catgtcaagt acaagatccg aatggacatt     1680

gacaatgtgg agaggacaaa taaaatcaag gatgggtact gggaccctgg tcctcgagct     1740

gacccctttg aggacatgcg gtacgtctgg gggggcttcg cctacttgca ggatgtggtg     1800

gagcaggcaa tcatcagggt gctgacgggc accgagaaga aaactggtgt ctatatgcaa     1860

cagatgccct atccctgtta cgttgatgac atctttctgc gggtgatgag ccggtcaatg     1920

cccctcttca tgacgctggc ctggatttac tcagtggctg tgatcatcaa gggcatcgtg     1980

tatgagaagg aggcacggct gaaagagacc atgcggatca tgggcctgga caacagcatc     2040

ctctggttta gctggttcat tagtagcctc attcctcttc ttgtgagcgc tggcctgcta     2100

gtggtcatcc tgaagttagg aaacctgctg ccctacagtg atcccagcgt ggtgtttgtc     2160

ttcctgtccg tgtttgctgt ggtgacaatc ctgcagtgct tcctgattag cacactcttc     2220

tccagagcca acctggcagc agcctgtggg ggcatcatct acttcacgct gtacctgccc     2280

tacgtcctgt gtgtggcatg gcaggactac gtgggcttca cactcaagat cttcgctagc     2340

ctgctgtctc ctgtggcttt tgggtttggc tgtgagtact ttgccctttt tgaggagcag     2400

ggcattggag tgcagtggga caacctgttt gagagtcctg tggaggaaga tggcttcaat     2460

ctcaccactt cggtctccat gatgctgttt gacaccttcc tctatggggt gatgacctgg     2520

tacattgagg ctgtctttcc aggccagtac ggaattccca ggccctggta ttttccttgc     2580

accaagtcct actggtttgg cgaggaaagt gatgagaaga gccaccctgg ttccaaccag     2640

aagagaatat cagaaatctg catggaggag gaacccaccc acttgaagct gggcgtgtcc     2700

attcagaacc tggtaaaagt ctaccgagat gggatgaagg tggctgtcga tggcctggca     2760

ctgaattttt atgagggcca gatcacctcc ttcctgggcc acaatggagc ggggaagacg     2820

accaccatgt caatcctgac cgggttgttc cccccgacct cgggcaccgc ctacatcctg     2880

ggaaaagaca ttcgctctga gatgagcacc atccggcaga acctgggggt ctgtccccag     2940

cataacgtgc tgtttgacat gctgactgtc gaagaacaca tctggttcta tgcccgcttg     3000

aaagggctct ctgagaagca cgtgaaggcg gagatggagc agatggccct ggatgttggt     3060

ttgccatcaa gcaagctgaa aagcaaaaca agccagctgt caggtggaat gcagagaaag     3120

ctatctgtgg ccttggcctt tgtcggggga tctaaggttg tcattctgga tgaacccaca     3180

gctggtgtgg acccttactc ccgcagggga atatgggagc tgctgctgaa ataccgacaa     3240

ggccgcacca ttattctctc tacacaccac atggatgaag cggacgtcct gggggacagg     3300

attgccatca tctcccatgg gaagctgtgc tgtgtgggct cctccctgtt tctgaagaac     3360

cagctgggaa caggctacta cctgaccttg gtcaagaaag atgtggaatc ctccctcagt     3420

tcctgcagaa acagtagtag cactgtgtca tacctgaaaa aggaggacag tgtttctcag     3480

agcagttctg atgctggcct gggcagcgac catgagagtg acacgctgac catcgatgtc     3540

tctgctatct ccaacctcat caggaagcat gtgtctgaag cccggctggt ggaagacata     3600

gggcatgagc tgacctatgt gctgccatat gaagctgcta aggagggagc ctttgtggaa     3660

ctctttcatg agattgatga ccggctctca gacctgggca tttctagtta tggcatctca     3720

gagacgaccc tggaagaaat attcctcaag gtggccgaag agagtggggt ggatgctgag     3780

acctcagatg gtaccttgcc agcaagacga aacaggcggg ccttcgggga caagcagagc     3840

tgtcttcgcc cgttcactga agatgatgct gctgatccaa atgattctga catagaccca     3900

gaatccagag agacagactt gctcagtggg atggatggca aagggtccta ccaggtgaaa     3960

ggctggaaac ttacacagca acagtttgtg gcccttttgt ggaagagact gctaattgcc     4020

agacggagtc ggaaaggatt ttttgctcag attgtcttgc cagctgtgtt tgtctgcatt     4080

gcccttgtgt tcagcctgat cgtgccaccc tttggcaagt accccagcct ggaacttcag     4140

ccctggatgt acaacgaaca gtacacattt gtcagcaatg atgctcctga ggacacggga     4200

accctggaac tcttaaacgc cctcaccaaa gaccctggct tcgggacccg ctgtatggaa     4260

ggaaacccaa tcccagacac gccctgccag gcaggggagg aagagtggac cactgcccca     4320

gttccccaga ccatcatgga cctcttccag aatgggaact ggacaatgca gaacccttca     4380

cctgcatgcc agtgtagcag cgacaaaatc aagaagatgc tgcctgtgtg tcccccaggg     4440

gcaggggggc tgcctcctcc acaaagaaaa caaaacactg cagatatcct tcaggacctg     4500

acaggaagaa acatttcgga ttatctggtg aagacgtatg tgcagatcat agccaaaagc     4560

ttaaagaaca agatctgggt gaatgagttt aggtatggcg gcttttccct gggtgtcagt     4620

aatactcaag cacttcctcc gagtcaagaa gttaatgatg ccatcaaaca aatgaagaaa     4680

cacctaaagc tggccaagga cagttctgca gatcgatttc tcaacagctt gggaagattt     4740

atgacaggac tggacaccaa aaataatgtc aaggtgtggt tcaataacaa gggctggcat     4800

gcaatcagct ctttcctgaa tgtcatcaac aatgccattc tccgggccaa cctgcaaaag     4860

ggagagaacc ctagccatta tggaattact gctttcaatc atcccctgaa tctcaccaag     4920

cagcagctct cagaggtggc tctgatgacc acatcagtgg atgtccttgt gtccatctgt     4980

gtcatctttg caatgtcctt cgtcccagcc agctttgtcg tattcctgat ccaggagcgg     5040

gtcagcaaag caaaacacct gcagttcatc agtggagtga agcctgtcat ctactggctc     5100

tctaattttg tctgggatat gtgcaattac gttgtccctg ccacactggt cattatcatc     5160

ttcatctgct tccagcagaa gtcctatgtg tcctccacca atctgcctgt gctagccctt     5220

ctacttttgc tgtatgggtg gtcaatcaca cctctcatgt acccagcctc ctttgtgttc     5280

aagatcccca gcacagccta tgtggtgctc accagcgtga acctcttcat tggcattaat     5340

ggcagcgtgg ccacctttgt gctggagctg ttcaccgaca ataagctgaa taatatcaat     5400

gatatcctga agtccgtgtt cttgatcttc ccacattttt gcctgggacg agggctcatc     5460

gacatggtga aaaaccaggc aatggctgat gccctggaaa ggtttgggga gaatcgcttt     5520

gtgtcaccat tatcttggga cttggtggga cgaaacctct tcgccatggc cgtggaaggg     5580

gtggtgttct tcctcattac tgttctgatc cagtacagat tcttcatcag gcccagacct     5640

gtaaatgcaa agctatctcc tctgaatgat gaagatgaag atgtgaggcg ggaaagacag     5700

agaattcttg atggtggagg ccagaatgac atcttagaaa tcaaggagtt gacgaagata     5760

tatagaagga agcggaagcc tgctgttgac aggatttgcg tgggcattcc tcctggtgag     5820

tgctttgggc tcctgggagt taatggggct ggaaaatcat caactttcaa gatgttaaca     5880

ggagatacca ctgttaccag aggagatgct ttccttaaca aaaatagtat cttatcaaac     5940

atccatgaag tacatcagaa catgggctac tgccctcagt ttgatgccat cacagagctg     6000

ttgactggga gagaacacgt ggagttcttt gcccttttga gaggagtccc agagaaagaa     6060

gttggcaagg ttggtgagtg ggcgattcgg aaactgggcc tcgtgaagta tggagaaaaa     6120

tatgctggta actatagtgg aggcaacaaa cgcaagctct ctacagccat ggctttgatc     6180

ggcgggcctc ctgtggtgtt tctggatgaa cccaccacag gcatggatcc caaagcccgg     6240

cggttcttgt ggaattgtgc cctaagtgtt gtcaaggagg ggagatcagt agtgcttaca     6300

tctcatagta tggaagaatg tgaagctctt tgcactagga tggcaatcat ggtcaatgga     6360

aggttcaggt gccttggcag tgtccagcat ctaaaaaata ggtttggaga tggttataca     6420

atagttgtac gaatagcagg gtccaacccg gacctgaagc ctgtccagga tttctttgga     6480

cttgcatttc ctggaagtgt tctaaaagag aaacaccgga acatgctaca ataccagctt     6540

ccatcttcat tatcttctct ggccaggata ttcagcatcc tctcccagag caaaaagcga     6600

ctccacatag aagactactc tgtttctcag acaacacttg accaagtatt tgtgaacttt     6660

gccaaggacc aaagtgatga tgaccactta aaagacctct cattacacaa aaaccagaca     6720

gtagtggacg ttgcagttct cacatctttt ctacaggatg agaaagtgaa agaaagctat     6780

gtatga                                                                6786


<210> 2
<211> 2261
<212> PRT
<213> Homo sapiens


<400> 2
Met Ala Cys Trp Pro Gln Leu Arg Leu Leu Leu Trp Lys Asn Leu Thr 
1               5                   10                  15      
Phe Arg Arg Arg Gln Thr Cys Gln Leu Leu Leu Glu Val Ala Trp Pro 
            20                  25                  30          
Leu Phe Ile Phe Leu Ile Leu Ile Ser Val Arg Leu Ser Tyr Pro Pro 
        35                  40                  45              
Tyr Glu Gln His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Thr Leu Pro Trp Val Gln Gly Ile Ile Cys Asn Ala Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Arg Tyr Pro Thr Pro Gly Glu Ala Pro Gly Val Val Gly Asn 
                85                  90                  95      
Phe Asn Lys Ser Ile Val Ala Arg Leu Phe Ser Asp Ala Arg Arg Leu 
            100                 105                 110         
Leu Leu Tyr Ser Gln Lys Asp Thr Ser Met Lys Asp Met Arg Lys Val 
        115                 120                 125             
Leu Arg Thr Leu Gln Gln Ile Lys Lys Ser Ser Ser Asn Leu Lys Leu 
    130                 135                 140                 
Gln Asp Phe Leu Val Asp Asn Glu Thr Phe Ser Gly Phe Leu Tyr His 
145                 150                 155                 160 
Asn Leu Ser Leu Pro Lys Ser Thr Val Asp Lys Met Leu Arg Ala Asp 
                165                 170                 175     
Val Ile Leu His Lys Val Phe Leu Gln Gly Tyr Gln Leu His Leu Thr 
            180                 185                 190         
Ser Leu Cys Asn Gly Ser Lys Ser Glu Glu Met Ile Gln Leu Gly Asp 
        195                 200                 205             
Gln Glu Val Ser Glu Leu Cys Gly Leu Pro Arg Glu Lys Leu Ala Ala 
    210                 215                 220                 
Ala Glu Arg Val Leu Arg Ser Asn Met Asp Ile Leu Lys Pro Ile Leu 
225                 230                 235                 240 
Arg Thr Leu Asn Ser Thr Ser Pro Phe Pro Ser Lys Glu Leu Ala Glu 
                245                 250                 255     
Ala Thr Lys Thr Leu Leu His Ser Leu Gly Thr Leu Ala Gln Glu Leu 
            260                 265                 270         
Phe Ser Met Arg Ser Trp Ser Asp Met Arg Gln Glu Val Met Phe Leu 
        275                 280                 285             
Thr Asn Val Asn Ser Ser Ser Ser Ser Thr Gln Ile Tyr Gln Ala Val 
    290                 295                 300                 
Ser Arg Ile Val Cys Gly His Pro Glu Gly Gly Gly Leu Lys Ile Lys 
305                 310                 315                 320 
Ser Leu Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Leu Phe Gly Gly 
                325                 330                 335     
Asn Gly Thr Glu Glu Asp Ala Glu Thr Phe Tyr Asp Asn Ser Thr Thr 
            340                 345                 350         
Pro Tyr Cys Asn Asp Leu Met Lys Asn Leu Glu Ser Ser Pro Leu Ser 
        355                 360                 365             
Arg Ile Ile Trp Lys Ala Leu Lys Pro Leu Leu Val Gly Lys Ile Leu 
    370                 375                 380                 
Tyr Thr Pro Asp Thr Pro Ala Thr Arg Gln Val Met Ala Glu Val Asn 
385                 390                 395                 400 
Lys Thr Phe Gln Glu Leu Ala Val Phe His Asp Leu Glu Gly Met Trp 
                405                 410                 415     
Glu Glu Leu Ser Pro Lys Ile Trp Thr Phe Met Glu Asn Ser Gln Glu 
            420                 425                 430         
Met Asp Leu Val Arg Met Leu Leu Asp Ser Arg Asp Asn Asp His Phe 
        435                 440                 445             
Trp Glu Gln Gln Leu Asp Gly Leu Asp Trp Thr Ala Gln Asp Ile Val 
    450                 455                 460                 
Ala Phe Leu Ala Lys His Pro Glu Asp Val Gln Ser Ser Asn Gly Ser 
465                 470                 475                 480 
Val Tyr Thr Trp Arg Glu Ala Phe Asn Glu Thr Asn Gln Ala Ile Arg 
                485                 490                 495     
Thr Ile Ser Arg Phe Met Glu Cys Val Asn Leu Asn Lys Leu Glu Pro 
            500                 505                 510         
Ile Ala Thr Glu Val Trp Leu Ile Asn Lys Ser Met Glu Leu Leu Asp 
        515                 520                 525             
Glu Arg Lys Phe Trp Ala Gly Ile Val Phe Thr Gly Ile Thr Pro Gly 
    530                 535                 540                 
Ser Ile Glu Leu Pro His His Val Lys Tyr Lys Ile Arg Met Asp Ile 
545                 550                 555                 560 
Asp Asn Val Glu Arg Thr Asn Lys Ile Lys Asp Gly Tyr Trp Asp Pro 
                565                 570                 575     
Gly Pro Arg Ala Asp Pro Phe Glu Asp Met Arg Tyr Val Trp Gly Gly 
            580                 585                 590         
Phe Ala Tyr Leu Gln Asp Val Val Glu Gln Ala Ile Ile Arg Val Leu 
        595                 600                 605             
Thr Gly Thr Glu Lys Lys Thr Gly Val Tyr Met Gln Gln Met Pro Tyr 
    610                 615                 620                 
Pro Cys Tyr Val Asp Asp Ile Phe Leu Arg Val Met Ser Arg Ser Met 
625                 630                 635                 640 
Pro Leu Phe Met Thr Leu Ala Trp Ile Tyr Ser Val Ala Val Ile Ile 
                645                 650                 655     
Lys Gly Ile Val Tyr Glu Lys Glu Ala Arg Leu Lys Glu Thr Met Arg 
            660                 665                 670         
Ile Met Gly Leu Asp Asn Ser Ile Leu Trp Phe Ser Trp Phe Ile Ser 
        675                 680                 685             
Ser Leu Ile Pro Leu Leu Val Ser Ala Gly Leu Leu Val Val Ile Leu 
    690                 695                 700                 
Lys Leu Gly Asn Leu Leu Pro Tyr Ser Asp Pro Ser Val Val Phe Val 
705                 710                 715                 720 
Phe Leu Ser Val Phe Ala Val Val Thr Ile Leu Gln Cys Phe Leu Ile 
                725                 730                 735     
Ser Thr Leu Phe Ser Arg Ala Asn Leu Ala Ala Ala Cys Gly Gly Ile 
            740                 745                 750         
Ile Tyr Phe Thr Leu Tyr Leu Pro Tyr Val Leu Cys Val Ala Trp Gln 
        755                 760                 765             
Asp Tyr Val Gly Phe Thr Leu Lys Ile Phe Ala Ser Leu Leu Ser Pro 
    770                 775                 780                 
Val Ala Phe Gly Phe Gly Cys Glu Tyr Phe Ala Leu Phe Glu Glu Gln 
785                 790                 795                 800 
Gly Ile Gly Val Gln Trp Asp Asn Leu Phe Glu Ser Pro Val Glu Glu 
                805                 810                 815     
Asp Gly Phe Asn Leu Thr Thr Ser Val Ser Met Met Leu Phe Asp Thr 
            820                 825                 830         
Phe Leu Tyr Gly Val Met Thr Trp Tyr Ile Glu Ala Val Phe Pro Gly 
        835                 840                 845             
Gln Tyr Gly Ile Pro Arg Pro Trp Tyr Phe Pro Cys Thr Lys Ser Tyr 
    850                 855                 860                 
Trp Phe Gly Glu Glu Ser Asp Glu Lys Ser His Pro Gly Ser Asn Gln 
865                 870                 875                 880 
Lys Arg Ile Ser Glu Ile Cys Met Glu Glu Glu Pro Thr His Leu Lys 
                885                 890                 895     
Leu Gly Val Ser Ile Gln Asn Leu Val Lys Val Tyr Arg Asp Gly Met 
            900                 905                 910         
Lys Val Ala Val Asp Gly Leu Ala Leu Asn Phe Tyr Glu Gly Gln Ile 
        915                 920                 925             
Thr Ser Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser 
    930                 935                 940                 
Ile Leu Thr Gly Leu Phe Pro Pro Thr Ser Gly Thr Ala Tyr Ile Leu 
945                 950                 955                 960 
Gly Lys Asp Ile Arg Ser Glu Met Ser Thr Ile Arg Gln Asn Leu Gly 
                965                 970                 975     
Val Cys Pro Gln His Asn Val Leu Phe Asp Met Leu Thr Val Glu Glu 
            980                 985                 990         
His Ile Trp Phe Tyr Ala Arg Leu Lys Gly Leu Ser Glu Lys His Val 
        995                 1000                1005            
Lys Ala Glu Met Glu Gln Met Ala Leu Asp Val Gly Leu Pro Ser Ser 
    1010                1015                1020                
Lys Leu Lys Ser Lys Thr Ser Gln Leu Ser Gly Gly Met Gln Arg Lys 
1025                1030                1035                1040
Leu Ser Val Ala Leu Ala Phe Val Gly Gly Ser Lys Val Val Ile Leu 
                1045                1050                1055    
Asp Glu Pro Thr Ala Gly Val Asp Pro Tyr Ser Arg Arg Gly Ile Trp 
            1060                1065                1070        
Glu Leu Leu Leu Lys Tyr Arg Gln Gly Arg Thr Ile Ile Leu Ser Thr 
        1075                1080                1085            
His His Met Asp Glu Ala Asp Val Leu Gly Asp Arg Ile Ala Ile Ile 
    1090                1095                1100                
Ser His Gly Lys Leu Cys Cys Val Gly Ser Ser Leu Phe Leu Lys Asn 
1105                1110                1115                1120
Gln Leu Gly Thr Gly Tyr Tyr Leu Thr Leu Val Lys Lys Asp Val Glu 
                1125                1130                1135    
Ser Ser Leu Ser Ser Cys Arg Asn Ser Ser Ser Thr Val Ser Tyr Leu 
            1140                1145                1150        
Lys Lys Glu Asp Ser Val Ser Gln Ser Ser Ser Asp Ala Gly Leu Gly 
        1155                1160                1165            
Ser Asp His Glu Ser Asp Thr Leu Thr Ile Asp Val Ser Ala Ile Ser 
    1170                1175                1180                
Asn Leu Ile Arg Lys His Val Ser Glu Ala Arg Leu Val Glu Asp Ile 
1185                1190                1195                1200
Gly His Glu Leu Thr Tyr Val Leu Pro Tyr Glu Ala Ala Lys Glu Gly 
                1205                1210                1215    
Ala Phe Val Glu Leu Phe His Glu Ile Asp Asp Arg Leu Ser Asp Leu 
            1220                1225                1230        
Gly Ile Ser Ser Tyr Gly Ile Ser Glu Thr Thr Leu Glu Glu Ile Phe 
        1235                1240                1245            
Leu Lys Val Ala Glu Glu Ser Gly Val Asp Ala Glu Thr Ser Asp Gly 
    1250                1255                1260                
Thr Leu Pro Ala Arg Arg Asn Arg Arg Ala Phe Gly Asp Lys Gln Ser 
1265                1270                1275                1280
Cys Leu Arg Pro Phe Thr Glu Asp Asp Ala Ala Asp Pro Asn Asp Ser 
                1285                1290                1295    
Asp Ile Asp Pro Glu Ser Arg Glu Thr Asp Leu Leu Ser Gly Met Asp 
            1300                1305                1310        
Gly Lys Gly Ser Tyr Gln Val Lys Gly Trp Lys Leu Thr Gln Gln Gln 
        1315                1320                1325            
Phe Val Ala Leu Leu Trp Lys Arg Leu Leu Ile Ala Arg Arg Ser Arg 
    1330                1335                1340                
Lys Gly Phe Phe Ala Gln Ile Val Leu Pro Ala Val Phe Val Cys Ile 
1345                1350                1355                1360
Ala Leu Val Phe Ser Leu Ile Val Pro Pro Phe Gly Lys Tyr Pro Ser 
                1365                1370                1375    
Leu Glu Leu Gln Pro Trp Met Tyr Asn Glu Gln Tyr Thr Phe Val Ser 
            1380                1385                1390        
Asn Asp Ala Pro Glu Asp Thr Gly Thr Leu Glu Leu Leu Asn Ala Leu 
        1395                1400                1405            
Thr Lys Asp Pro Gly Phe Gly Thr Arg Cys Met Glu Gly Asn Pro Ile 
    1410                1415                1420                
Pro Asp Thr Pro Cys Gln Ala Gly Glu Glu Glu Trp Thr Thr Ala Pro 
1425                1430                1435                1440
Val Pro Gln Thr Ile Met Asp Leu Phe Gln Asn Gly Asn Trp Thr Met 
                1445                1450                1455    
Gln Asn Pro Ser Pro Ala Cys Gln Cys Ser Ser Asp Lys Ile Lys Lys 
            1460                1465                1470        
Met Leu Pro Val Cys Pro Pro Gly Ala Gly Gly Leu Pro Pro Pro Gln 
        1475                1480                1485            
Arg Lys Gln Asn Thr Ala Asp Ile Leu Gln Asp Leu Thr Gly Arg Asn 
    1490                1495                1500                
Ile Ser Asp Tyr Leu Val Lys Thr Tyr Val Gln Ile Ile Ala Lys Ser 
1505                1510                1515                1520
Leu Lys Asn Lys Ile Trp Val Asn Glu Phe Arg Tyr Gly Gly Phe Ser 
                1525                1530                1535    
Leu Gly Val Ser Asn Thr Gln Ala Leu Pro Pro Ser Gln Glu Val Asn 
            1540                1545                1550        
Asp Ala Ile Lys Gln Met Lys Lys His Leu Lys Leu Ala Lys Asp Ser 
        1555                1560                1565            
Ser Ala Asp Arg Phe Leu Asn Ser Leu Gly Arg Phe Met Thr Gly Leu 
    1570                1575                1580                
Asp Thr Lys Asn Asn Val Lys Val Trp Phe Asn Asn Lys Gly Trp His 
1585                1590                1595                1600
Ala Ile Ser Ser Phe Leu Asn Val Ile Asn Asn Ala Ile Leu Arg Ala 
                1605                1610                1615    
Asn Leu Gln Lys Gly Glu Asn Pro Ser His Tyr Gly Ile Thr Ala Phe 
            1620                1625                1630        
Asn His Pro Leu Asn Leu Thr Lys Gln Gln Leu Ser Glu Val Ala Leu 
        1635                1640                1645            
Met Thr Thr Ser Val Asp Val Leu Val Ser Ile Cys Val Ile Phe Ala 
    1650                1655                1660                
Met Ser Phe Val Pro Ala Ser Phe Val Val Phe Leu Ile Gln Glu Arg 
1665                1670                1675                1680
Val Ser Lys Ala Lys His Leu Gln Phe Ile Ser Gly Val Lys Pro Val 
                1685                1690                1695    
Ile Tyr Trp Leu Ser Asn Phe Val Trp Asp Met Cys Asn Tyr Val Val 
            1700                1705                1710        
Pro Ala Thr Leu Val Ile Ile Ile Phe Ile Cys Phe Gln Gln Lys Ser 
        1715                1720                1725            
Tyr Val Ser Ser Thr Asn Leu Pro Val Leu Ala Leu Leu Leu Leu Leu 
    1730                1735                1740                
Tyr Gly Trp Ser Ile Thr Pro Leu Met Tyr Pro Ala Ser Phe Val Phe 
1745                1750                1755                1760
Lys Ile Pro Ser Thr Ala Tyr Val Val Leu Thr Ser Val Asn Leu Phe 
                1765                1770                1775    
Ile Gly Ile Asn Gly Ser Val Ala Thr Phe Val Leu Glu Leu Phe Thr 
            1780                1785                1790        
Asp Asn Lys Leu Asn Asn Ile Asn Asp Ile Leu Lys Ser Val Phe Leu 
        1795                1800                1805            
Ile Phe Pro His Phe Cys Leu Gly Arg Gly Leu Ile Asp Met Val Lys 
    1810                1815                1820                
Asn Gln Ala Met Ala Asp Ala Leu Glu Arg Phe Gly Glu Asn Arg Phe 
1825                1830                1835                1840
Val Ser Pro Leu Ser Trp Asp Leu Val Gly Arg Asn Leu Phe Ala Met 
                1845                1850                1855    
Ala Val Glu Gly Val Val Phe Phe Leu Ile Thr Val Leu Ile Gln Tyr 
            1860                1865                1870        
Arg Phe Phe Ile Arg Pro Arg Pro Val Asn Ala Lys Leu Ser Pro Leu 
        1875                1880                1885            
Asn Asp Glu Asp Glu Asp Val Arg Arg Glu Arg Gln Arg Ile Leu Asp 
    1890                1895                1900                
Gly Gly Gly Gln Asn Asp Ile Leu Glu Ile Lys Glu Leu Thr Lys Ile 
1905                1910                1915                1920
Tyr Arg Arg Lys Arg Lys Pro Ala Val Asp Arg Ile Cys Val Gly Ile 
                1925                1930                1935    
Pro Pro Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys 
            1940                1945                1950        
Ser Ser Thr Phe Lys Met Leu Thr Gly Asp Thr Thr Val Thr Arg Gly 
        1955                1960                1965            
Asp Ala Phe Leu Asn Lys Asn Ser Ile Leu Ser Asn Ile His Glu Val 
    1970                1975                1980                
His Gln Asn Met Gly Tyr Cys Pro Gln Phe Asp Ala Ile Thr Glu Leu 
1985                1990                1995                2000
Leu Thr Gly Arg Glu His Val Glu Phe Phe Ala Leu Leu Arg Gly Val 
                2005                2010                2015    
Pro Glu Lys Glu Val Gly Lys Val Gly Glu Trp Ala Ile Arg Lys Leu 
            2020                2025                2030        
Gly Leu Val Lys Tyr Gly Glu Lys Tyr Ala Gly Asn Tyr Ser Gly Gly 
        2035                2040                2045            
Asn Lys Arg Lys Leu Ser Thr Ala Met Ala Leu Ile Gly Gly Pro Pro 
    2050                2055                2060                
Val Val Phe Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Lys Ala Arg 
2065                2070                2075                2080
Arg Phe Leu Trp Asn Cys Ala Leu Ser Val Val Lys Glu Gly Arg Ser 
                2085                2090                2095    
Val Val Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr 
            2100                2105                2110        
Arg Met Ala Ile Met Val Asn Gly Arg Phe Arg Cys Leu Gly Ser Val 
        2115                2120                2125            
Gln His Leu Lys Asn Arg Phe Gly Asp Gly Tyr Thr Ile Val Val Arg 
    2130                2135                2140                
Ile Ala Gly Ser Asn Pro Asp Leu Lys Pro Val Gln Asp Phe Phe Gly 
2145                2150                2155                2160
Leu Ala Phe Pro Gly Ser Val Leu Lys Glu Lys His Arg Asn Met Leu 
                2165                2170                2175    
Gln Tyr Gln Leu Pro Ser Ser Leu Ser Ser Leu Ala Arg Ile Phe Ser 
            2180                2185                2190        
Ile Leu Ser Gln Ser Lys Lys Arg Leu His Ile Glu Asp Tyr Ser Val 
        2195                2200                2205            
Ser Gln Thr Thr Leu Asp Gln Val Phe Val Asn Phe Ala Lys Asp Gln 
    2210                2215                2220                
Ser Asp Asp Asp His Leu Lys Asp Leu Ser Leu His Lys Asn Gln Thr 
2225                2230                2235                2240
Val Val Asp Val Ala Val Leu Thr Ser Phe Leu Gln Asp Glu Lys Val 
                2245                2250                2255    
Lys Glu Ser Tyr Val 
            2260    

<210> 3
<211> 7311
<212> DNA
<213> Homo sapiens


<400> 3
atgggcttcc tgcaccagct gcagctgctg ctctggaaga acgtgacgct caaacgccgg       60

agcccgtggg tcctggcctt cgagatcttc atccccctgg tgctgttctt tatcctgctg      120

gggctgcgac agaagaagcc caccatctcc gtgaaggaag tctccttcta cacagcggcg      180

cccctgacgt ctgccggcat cctgcctgtc atgcaatcgc tgtgcccgga cggccagcga      240

gacgagttcg gcttcctgca gtacgccaac tccacggtca cgcagctgct tgagcgcctg      300

gaccgcgtgg tggaggaagg caacctgttt gacccagcgc ggcccagcct gggctcagag      360

ctcgaggccc tacgccagca tctggaggcc ctcagtgcgg gcccgggcac ctcggggagc      420

cacctggaca gatccacagt gtcttccttc tctctggact cggtggccag aaacccgcag      480

gagctctggc gtttcctgac gcaaaacttg tcgctgccca atagcacggc ccaagcactc      540

ttggccgccc gtgtggaccc gcccgaggtc taccacctgc tctttggtcc ctcatctgcc      600

ctggattcac agtctggcct ccacaagggt caggagccct ggagccgcct agggggcaat      660

cccctgttcc ggatggagga gctgctgctg gctcctgccc tcctggagca gctcacctgc      720

acgccgggct cgggggagct gggccggatc ctcactgtgc ctgagagtca gaagggagcc      780

ctgcagggct accgggatgc tgtctgcagt gggcaggctg ctgcgcgtgc caggcgcttc      840

tctgggctgt ctgctgagct ccggaaccag ctggacgtgg ccaaggtctc ccagcagctg      900

ggcctggatg cccccaacgg ctcggactcc tcgccacagg cgccaccccc acggaggctg      960

caggcgcttc tgggggacct gctggatgcc cagaaggttc tgcaggatgt ggatgtcctg     1020

tcggccctgg ccctgctact gccccagggt gcctgcactg gccggacccc cggaccccca     1080

gccagtggtg cgggtggggc ggccaatggc actggggcag gggcagtcat gggccccaac     1140

gccaccgctg aggagggcgc accctctgct gcagcactgg ccaccccgga cacgctgcag     1200

ggccagtgct cagccttcgt acagctctgg gccggcctgc agcccatctt gtgtggcaac     1260

aaccgcacca ttgaacccga ggcgctgcgg cggggcaaca tgagctccct gggcttcacg     1320

agcaaggagc agcggaacct gggcctcctc gtgcacctca tgaccagcaa ccccaaaatc     1380

ctgtacgcgc ctgcgggctc tgaggtcgac cgcgtcatcc tcaaggccaa cgagactttt     1440

gcttttgtgg gcaacgtgac tcactatgcc caggtctggc tcaacatctc ggcggagatc     1500

cgcagcttcc tggagcaggg caggctgcag caacacctgc gctggctgca gcagtatgta     1560

gcagagctgc ggctgcaccc cgaggcactg aacctgtcac tggatgagct gccgccggcc     1620

ctgagacagg acaacttctc gctgcccagt ggcatggccc tcctgcagca gctggatacc     1680

attgacaacg cggcctgcgg ctggatccag ttcatgtcca aggtgagcgt ggacatcttc     1740

aagggcttcc ccgacgagga gagcattgtc aactacaccc tcaaccaggc ctaccaggac     1800

aacgtcactg tttttgccag tgtgatcttc cagacccgga aggacggctc gctcccgcct     1860

cacgtgcact acaagatccg ccagaactcc agcttcaccg agaaaaccaa cgagatccgc     1920

cgcgcctact ggcggcctgg gcccaatact ggcggccgct tctacttcct ctacggcttc     1980

gtctggatcc aggacatgat ggagcgcgcc atcatcgaca cttttgtggg gcacgatgtg     2040

gtggagccag gcagctacgt gcagatgttc ccctacccct gctacacacg cgatgacttc     2100

ctgtttgtca ttgagcacat gatgccgctg tgcatggtga tctcctgggt ctactccgtg     2160

gccatgacca tccagcacat cgtggcggag aaggagcacc ggctcaagga ggtgatgaag     2220

accatgggcc tgaacaacgc ggtgcactgg gtggcctggt tcatcaccgg ctttgtgcag     2280

ctgtccatct ccgtgacagc actcaccgcc atcctgaagt acggccaggt gcttatgcac     2340

agccacgtgg tcatcatctg gctcttcctg gcagtctacg cggtggccac catcatgttc     2400

tgcttcctgg tgtctgtgct gtactccaag gccaagctgg cctcggcctg cggtggcatc     2460

atctacttcc tgagctacgt gccctacatg tacgtggcga tccgagagga ggtggcgcat     2520

gataagatca cggccttcga gaagtgcatc gcgtccctca tgtccacgac ggcctttggt     2580

ctgggctcta agtacttcgc gctgtatgag gtggccggcg tgggcatcca gtggcacacc     2640

ttcagccagt ccccggtgga gggggacgac ttcaacttgc tcctggctgt caccatgctg     2700

atggtggacg ccgtggtcta tggcatcctc acgtggtaca ttgaggctgt gcacccaggc     2760

atgtacgggc tgccccggcc ctggtacttc ccactgcaga agtcctactg gctgggcagt     2820

gggcggacag aagcctggga gtggagctgg ccgtgggcac gcaccccccg cctcagtgtc     2880

atggaggagg accaggcctg tgccatggag agccggcgct ttgaggagac ccgtggcatg     2940

gaggaggagc ccacccacct gcctctggtt gtctgcgtgg acaaactcac caaggtctac     3000

aaggacgaca agaagctggc cctgaacaag ctgagcctga acctctacga gaaccaggtg     3060

gtctccttct tgggccacaa cggggcgggc aagaccacca ccatgtccat cctgaccggc     3120

ctgttccctc caacgtcggg ttccgccacc atctacgggc acgacatccg cacggagatg     3180

gatgagatcc gcaagaacct gggcatgtgc ccgcagcaca atgtgctctt tgaccggctc     3240

acggtggagg aacacctctg gttctactca cggctcaaga gcatggctca ggaggagatc     3300

cgcagagaga tggacaagat gatcgaggac ctggagctct ccaacaaacg gcactcactg     3360

gtgcagacat tgtcgggtgg catgaagcgc aagctgtccg tggccatcgc cttcgtgggc     3420

ggctctcgcg ccatcatcct ggacgagccc acggcgggcg tggaccccta cgcgcgccgc     3480

gccatctggg acctcatcct gaagtacaag ccaggccgca ccatccttct gtccacccac     3540

cacatggatg aggctgacct gcttggggac cgcattgcca tcatctccca tgggaagctc     3600

aagtgctgcg gctccccgct cttcctcaag ggcacctatg gcgacgggta ccgcctcacg     3660

ctggtcaagc ggcccgccga gccggggggc ccccaagagc cagggctggc atccagcccc     3720

ccaggtcggg ccccgctgag cagctgctcc gagctccagg tgtcccagtt catccgcaag     3780

catgtggcct cctgcctgct ggtctcagac acaagcacgg agctctccta catcctgccc     3840

agcgaggccg ccaagaaggg ggctttcgag cgcctcttcc agcacctgga gcgcagcctg     3900

gatgcactgc acctcagcag cttcgggctg atggacacga ccctggagga agtgttcctc     3960

aaggtgtcgg aggaggatca gtcgctggag aacagtgagg ccgatgtgaa ggagtccagg     4020

aaggatgtgc tccctggggc ggagggcccg gcgtctgggg agggtcacgc tggcaatctg     4080

gcccggtgct cggagctgac ccagtcgcag gcatcgctgc agtcggcgtc atctgtgggc     4140

tctgcccgtg gcgacgaggg agctggctac accgacgtct atggcgacta ccgccccctc     4200

tttgataacc cacaggaccc agacaatgtc agcctgcaag aggtggaggc agaggccctg     4260

tcgagggtcg gccagggcag ccgcaagctg gacggcgggt ggctgaaggt gcgccagttc     4320

cacgggctgc tggtcaaacg cttccactgc gcccgccgca actccaaggc actcttctcc     4380

cagatcttgc tgccagcctt cttcgtctgc gtggccatga ccgtggccct gtccgtcccg     4440

gagattggtg atctgccccc gctggtcctg tcaccttccc agtaccacaa ctacacccag     4500

ccccgtggca atttcatccc ctacgccaac gaggagcgcc gcgagtaccg gctgcggcta     4560

tcgcccgacg ccagccccca gcagctcgtg agcacgttcc ggctgccgtc gggggtgggt     4620

gccacctgcg tgctcaagtc tcccgccaac ggctcgctgg ggcccacgtt gaacctgagc     4680

agcggggagt cgcgcctgct ggcggctcgg ttcttcgaca gcatgtgtct ggagtccttc     4740

acacaggggc tgccactgtc caatttcgtg ccacccccac cctcgcccgc cccatctgac     4800

tcgccagcgt ccccggatga ggacctgcag gcctggaacg tctccctgcc gcccaccgct     4860

gggccagaaa tgtggacgtc ggcaccctcc ctgccgcgcc tggtacggga gcccgtccgc     4920

tgcacctgct ctgcgcaggg caccggcttc tcctgcccca gcagtgtggg cgggcacccg     4980

ccccagatgc gggtggtcac aggcgacatc ctgaccgaca tcaccggcca caatgtctct     5040

gagtacctgc tcttcacctc cgaccgcttc cgactgcacc ggtatggggc catcaccttt     5100

ggaaacgtcc tgaagtccat cccagcctca tttggcacca gggccccacc catggtgcgg     5160

aagatcgcgg tgcgcagggc tgcccaggtt ttctacaaca acaagggcta tcacagcatg     5220

cccacctacc tcaacagcct caacaacgcc atcctgcgtg ccaacctgcc caagagcaag     5280

ggcaacccgg cggcttacgg catcaccgtc accaaccacc ccatgaataa gaccagcgcc     5340

agcctctccc tggattacct gctgcagggc acggatgtcg tcatcgccat cttcatcatc     5400

gtggccatgt ccttcgtgcc ggccagcttc gttgtcttcc tcgtggccga gaagtccacc     5460

aaggccaagc acctgcagtt tgtcagcggc tgcaacccca tcatctactg gctggcgaac     5520

tacgtgtggg acatgctcaa ctacctggtc cccgctacct gctgtgtcat catcctgttt     5580

gtgttcgacc tgccggccta cacgtcgccc accaacttcc ctgccgtcct ctccctcttc     5640

ctgctctatg ggtggtccat cacgcccatc atgtacccgg cctccttctg gttcgaggtc     5700

cccagctccg cctacgtgtt cctcattgtc atcaatctct tcatcggcat caccgccacc     5760

gtggccacct tcctgctaca gctcttcgag cacgacaagg acctgaaggt tgtcaacagt     5820

tacctgaaaa gctgcttcct cattttcccc aactacaacc tgggccacgg gctcatggag     5880

atggcctaca acgagtacat caacgagtac tacgccaaga ttggccagtt tgacaagatg     5940

aagtccccgt tcgagtggga cattgtcacc cgcggactgg tggccatggc ggttgagggc     6000

gtcgtgggct tcctcctgac catcatgtgc cagtacaact tcctgcggcg gccacagcgc     6060

atgcctgtgt ctaccaagcc tgtggaggat gatgtggacg tggccagtga gcggcagcga     6120

gtgctccggg gagacgccga caatgacatg gtcaagattg agaacctgac caaggtctac     6180

aagtcccgga agattggccg tatcctggcc gttgaccgcc tgtgcctggg tgtgcgtcct     6240

ggcgagtgct tcgggctcct gggcgtcaac ggtgcgggca agaccagcac cttcaagatg     6300

ctgaccggcg acgagagcac gacggggggc gaggccttcg tcaatggaca cagcgtgctg     6360

aaggagctgc tccaggtgca gcagagcctc ggctactgcc cgcagtgtga cgcgctgttc     6420

gacgagctca cggcccggga gcacctgcag ctgtacacgc ggctgcgtgg gatctcctgg     6480

aaggacgagg cccgggtggt gaagtgggct ctggagaagc tggagctgac caagtacgca     6540

gacaagccgg ctggcaccta cagcggcggc aacaagcgga agctctccac ggccatcgcc     6600

ctcattgggt acccagcctt catcttcctg gacgagccca ccacaggcat ggaccccaag     6660

gcccggcgct tcctctggaa cctcatcctt gacctcatca agacagggcg ttcagtggtg     6720

ctgacatcac acagcatgga ggagtgcgag gcgctgtgca cgcggctggc catcatggtg     6780

aacggtcgcc tgcggtgcct gggcagcatc cagcacctga agaaccggtt tggagatggc     6840

tacatgatca cggtgcggac caagagcagc cagagtgtga aggacgtggt gcggttcttc     6900

aaccgcaact tcccggaagc catgctcaag gagcggcacc acacaaaggt gcagtaccag     6960

ctcaagtcgg agcacatctc gctggcccag gtgttcagca agatggagca ggtgtctggc     7020

gtgctgggca tcgaggacta ctcggtcagc cagaccacac tggacaatgt gttcgtgaac     7080

tttgccaaga agcagagtga caacctggag cagcaggaga cggagccgcc atccgcactg     7140

cagtcccctc tcggctgctt gctcagcctg ctccggcccc ggtctgcccc cacggagctc     7200

cgggcacttg tggcagacga gcccgaggac ctggacacgg aggacgaggg cctcatcagc     7260

ttcgaggagg agcgggccca gctgtccttc aacacggaca cgctctgctg a              7311


<210> 4
<211> 2436
<212> PRT
<213> Homo sapiens


<400> 4
Met Gly Phe Leu His Gln Leu Gln Leu Leu Leu Trp Lys Asn Val Thr 
1               5                   10                  15      
Leu Lys Arg Arg Ser Pro Trp Val Leu Ala Phe Glu Ile Phe Ile Pro 
            20                  25                  30          
Leu Val Leu Phe Phe Ile Leu Leu Gly Leu Arg Gln Lys Lys Pro Thr 
        35                  40                  45              
Ile Ser Val Lys Glu Val Ser Phe Tyr Thr Ala Ala Pro Leu Thr Ser 
    50                  55                  60                  
Ala Gly Ile Leu Pro Val Met Gln Ser Leu Cys Pro Asp Gly Gln Arg 
65                  70                  75                  80  
Asp Glu Phe Gly Phe Leu Gln Tyr Ala Asn Ser Thr Val Thr Gln Leu 
                85                  90                  95      
Leu Glu Arg Leu Asp Arg Val Val Glu Glu Gly Asn Leu Phe Asp Pro 
            100                 105                 110         
Ala Arg Pro Ser Leu Gly Ser Glu Leu Glu Ala Leu Arg Gln His Leu 
        115                 120                 125             
Glu Ala Leu Ser Ala Gly Pro Gly Thr Ser Gly Ser His Leu Asp Arg 
    130                 135                 140                 
Ser Thr Val Ser Ser Phe Ser Leu Asp Ser Val Ala Arg Asn Pro Gln 
145                 150                 155                 160 
Glu Leu Trp Arg Phe Leu Thr Gln Asn Leu Ser Leu Pro Asn Ser Thr 
                165                 170                 175     
Ala Gln Ala Leu Leu Ala Ala Arg Val Asp Pro Pro Glu Val Tyr His 
            180                 185                 190         
Leu Leu Phe Gly Pro Ser Ser Ala Leu Asp Ser Gln Ser Gly Leu His 
        195                 200                 205             
Lys Gly Gln Glu Pro Trp Ser Arg Leu Gly Gly Asn Pro Leu Phe Arg 
    210                 215                 220                 
Met Glu Glu Leu Leu Leu Ala Pro Ala Leu Leu Glu Gln Leu Thr Cys 
225                 230                 235                 240 
Thr Pro Gly Ser Gly Glu Leu Gly Arg Ile Leu Thr Val Pro Glu Ser 
                245                 250                 255     
Gln Lys Gly Ala Leu Gln Gly Tyr Arg Asp Ala Val Cys Ser Gly Gln 
            260                 265                 270         
Ala Ala Ala Arg Ala Arg Arg Phe Ser Gly Leu Ser Ala Glu Leu Arg 
        275                 280                 285             
Asn Gln Leu Asp Val Ala Lys Val Ser Gln Gln Leu Gly Leu Asp Ala 
    290                 295                 300                 
Pro Asn Gly Ser Asp Ser Ser Pro Gln Ala Pro Pro Pro Arg Arg Leu 
305                 310                 315                 320 
Gln Ala Leu Leu Gly Asp Leu Leu Asp Ala Gln Lys Val Leu Gln Asp 
                325                 330                 335     
Val Asp Val Leu Ser Ala Leu Ala Leu Leu Leu Pro Gln Gly Ala Cys 
            340                 345                 350         
Thr Gly Arg Thr Pro Gly Pro Pro Ala Ser Gly Ala Gly Gly Ala Ala 
        355                 360                 365             
Asn Gly Thr Gly Ala Gly Ala Val Met Gly Pro Asn Ala Thr Ala Glu 
    370                 375                 380                 
Glu Gly Ala Pro Ser Ala Ala Ala Leu Ala Thr Pro Asp Thr Leu Gln 
385                 390                 395                 400 
Gly Gln Cys Ser Ala Phe Val Gln Leu Trp Ala Gly Leu Gln Pro Ile 
                405                 410                 415     
Leu Cys Gly Asn Asn Arg Thr Ile Glu Pro Glu Ala Leu Arg Arg Gly 
            420                 425                 430         
Asn Met Ser Ser Leu Gly Phe Thr Ser Lys Glu Gln Arg Asn Leu Gly 
        435                 440                 445             
Leu Leu Val His Leu Met Thr Ser Asn Pro Lys Ile Leu Tyr Ala Pro 
    450                 455                 460                 
Ala Gly Ser Glu Val Asp Arg Val Ile Leu Lys Ala Asn Glu Thr Phe 
465                 470                 475                 480 
Ala Phe Val Gly Asn Val Thr His Tyr Ala Gln Val Trp Leu Asn Ile 
                485                 490                 495     
Ser Ala Glu Ile Arg Ser Phe Leu Glu Gln Gly Arg Leu Gln Gln His 
            500                 505                 510         
Leu Arg Trp Leu Gln Gln Tyr Val Ala Glu Leu Arg Leu His Pro Glu 
        515                 520                 525             
Ala Leu Asn Leu Ser Leu Asp Glu Leu Pro Pro Ala Leu Arg Gln Asp 
    530                 535                 540                 
Asn Phe Ser Leu Pro Ser Gly Met Ala Leu Leu Gln Gln Leu Asp Thr 
545                 550                 555                 560 
Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys Val Ser 
                565                 570                 575     
Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val Asn Tyr 
            580                 585                 590         
Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala Ser Val 
        595                 600                 605             
Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val His Tyr 
    610                 615                 620                 
Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu Ile Arg 
625                 630                 635                 640 
Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe Tyr Phe 
                645                 650                 655     
Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala Ile Ile 
            660                 665                 670         
Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr Val Gln 
        675                 680                 685             
Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe Val Ile 
    690                 695                 700                 
Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr Ser Val 
705                 710                 715                 720 
Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg Leu Lys 
                725                 730                 735     
Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp Val Ala 
            740                 745                 750         
Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr Ala Leu 
        755                 760                 765             
Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His Val Val 
    770                 775                 780                 
Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile Met Phe 
785                 790                 795                 800 
Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala Ser Ala 
                805                 810                 815     
Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met Tyr Val 
            820                 825                 830         
Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe Glu Lys 
        835                 840                 845             
Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly Ser Lys 
    850                 855                 860                 
Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp His Thr 
865                 870                 875                 880 
Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu Leu Ala 
                885                 890                 895     
Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu Thr Trp 
            900                 905                 910         
Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg Pro Trp 
        915                 920                 925             
Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg Thr Glu 
    930                 935                 940                 
Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu Ser Val 
945                 950                 955                 960 
Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe Glu Glu 
                965                 970                 975     
Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val Val Cys 
            980                 985                 990         
Val Asp Lys Leu Thr Lys Val Tyr Lys Asp Asp Lys Lys Leu Ala Leu 
        995                 1000                1005            
Asn Lys Leu Ser Leu Asn Leu Tyr Glu Asn Gln Val Val Ser Phe Leu 
    1010                1015                1020                
Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser Ile Leu Thr Gly 
1025                1030                1035                1040
Leu Phe Pro Pro Thr Ser Gly Ser Ala Thr Ile Tyr Gly His Asp Ile 
                1045                1050                1055    
Arg Thr Glu Met Asp Glu Ile Arg Lys Asn Leu Gly Met Cys Pro Gln 
            1060                1065                1070        
His Asn Val Leu Phe Asp Arg Leu Thr Val Glu Glu His Leu Trp Phe 
        1075                1080                1085            
Tyr Ser Arg Leu Lys Ser Met Ala Gln Glu Glu Ile Arg Arg Glu Met 
    1090                1095                1100                
Asp Lys Met Ile Glu Asp Leu Glu Leu Ser Asn Lys Arg His Ser Leu 
1105                1110                1115                1120
Val Gln Thr Leu Ser Gly Gly Met Lys Arg Lys Leu Ser Val Ala Ile 
                1125                1130                1135    
Ala Phe Val Gly Gly Ser Arg Ala Ile Ile Leu Asp Glu Pro Thr Ala 
            1140                1145                1150        
Gly Val Asp Pro Tyr Ala Arg Arg Ala Ile Trp Asp Leu Ile Leu Lys 
        1155                1160                1165            
Tyr Lys Pro Gly Arg Thr Ile Leu Leu Ser Thr His His Met Asp Glu 
    1170                1175                1180                
Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ser His Gly Lys Leu 
1185                1190                1195                1200
Lys Cys Cys Gly Ser Pro Leu Phe Leu Lys Gly Thr Tyr Gly Asp Gly 
                1205                1210                1215    
Tyr Arg Leu Thr Leu Val Lys Arg Pro Ala Glu Pro Gly Gly Pro Gln 
            1220                1225                1230        
Glu Pro Gly Leu Ala Ser Ser Pro Pro Gly Arg Ala Pro Leu Ser Ser 
        1235                1240                1245            
Cys Ser Glu Leu Gln Val Ser Gln Phe Ile Arg Lys His Val Ala Ser 
    1250                1255                1260                
Cys Leu Leu Val Ser Asp Thr Ser Thr Glu Leu Ser Tyr Ile Leu Pro 
1265                1270                1275                1280
Ser Glu Ala Ala Lys Lys Gly Ala Phe Glu Arg Leu Phe Gln His Leu 
                1285                1290                1295    
Glu Arg Ser Leu Asp Ala Leu His Leu Ser Ser Phe Gly Leu Met Asp 
            1300                1305                1310        
Thr Thr Leu Glu Glu Val Phe Leu Lys Val Ser Glu Glu Asp Gln Ser 
        1315                1320                1325            
Leu Glu Asn Ser Glu Ala Asp Val Lys Glu Ser Arg Lys Asp Val Leu 
    1330                1335                1340                
Pro Gly Ala Glu Gly Pro Ala Ser Gly Glu Gly His Ala Gly Asn Leu 
1345                1350                1355                1360
Ala Arg Cys Ser Glu Leu Thr Gln Ser Gln Ala Ser Leu Gln Ser Ala 
                1365                1370                1375    
Ser Ser Val Gly Ser Ala Arg Gly Asp Glu Gly Ala Gly Tyr Thr Asp 
            1380                1385                1390        
Val Tyr Gly Asp Tyr Arg Pro Leu Phe Asp Asn Pro Gln Asp Pro Asp 
        1395                1400                1405            
Asn Val Ser Leu Gln Glu Val Glu Ala Glu Ala Leu Ser Arg Val Gly 
    1410                1415                1420                
Gln Gly Ser Arg Lys Leu Asp Gly Gly Trp Leu Lys Val Arg Gln Phe 
1425                1430                1435                1440
His Gly Leu Leu Val Lys Arg Phe His Cys Ala Arg Arg Asn Ser Lys 
                1445                1450                1455    
Ala Leu Phe Ser Gln Ile Leu Leu Pro Ala Phe Phe Val Cys Val Ala 
            1460                1465                1470        
Met Thr Val Ala Leu Ser Val Pro Glu Ile Gly Asp Leu Pro Pro Leu 
        1475                1480                1485            
Val Leu Ser Pro Ser Gln Tyr His Asn Tyr Thr Gln Pro Arg Gly Asn 
    1490                1495                1500                
Phe Ile Pro Tyr Ala Asn Glu Glu Arg Arg Glu Tyr Arg Leu Arg Leu 
1505                1510                1515                1520
Ser Pro Asp Ala Ser Pro Gln Gln Leu Val Ser Thr Phe Arg Leu Pro 
                1525                1530                1535    
Ser Gly Val Gly Ala Thr Cys Val Leu Lys Ser Pro Ala Asn Gly Ser 
            1540                1545                1550        
Leu Gly Pro Thr Leu Asn Leu Ser Ser Gly Glu Ser Arg Leu Leu Ala 
        1555                1560                1565            
Ala Arg Phe Phe Asp Ser Met Cys Leu Glu Ser Phe Thr Gln Gly Leu 
    1570                1575                1580                
Pro Leu Ser Asn Phe Val Pro Pro Pro Pro Ser Pro Ala Pro Ser Asp 
1585                1590                1595                1600
Ser Pro Ala Ser Pro Asp Glu Asp Leu Gln Ala Trp Asn Val Ser Leu 
                1605                1610                1615    
Pro Pro Thr Ala Gly Pro Glu Met Trp Thr Ser Ala Pro Ser Leu Pro 
            1620                1625                1630        
Arg Leu Val Arg Glu Pro Val Arg Cys Thr Cys Ser Ala Gln Gly Thr 
        1635                1640                1645            
Gly Phe Ser Cys Pro Ser Ser Val Gly Gly His Pro Pro Gln Met Arg 
    1650                1655                1660                
Val Val Thr Gly Asp Ile Leu Thr Asp Ile Thr Gly His Asn Val Ser 
1665                1670                1675                1680
Glu Tyr Leu Leu Phe Thr Ser Asp Arg Phe Arg Leu His Arg Tyr Gly 
                1685                1690                1695    
Ala Ile Thr Phe Gly Asn Val Leu Lys Ser Ile Pro Ala Ser Phe Gly 
            1700                1705                1710        
Thr Arg Ala Pro Pro Met Val Arg Lys Ile Ala Val Arg Arg Ala Ala 
        1715                1720                1725            
Gln Val Phe Tyr Asn Asn Lys Gly Tyr His Ser Met Pro Thr Tyr Leu 
    1730                1735                1740                
Asn Ser Leu Asn Asn Ala Ile Leu Arg Ala Asn Leu Pro Lys Ser Lys 
1745                1750                1755                1760
Gly Asn Pro Ala Ala Tyr Gly Ile Thr Val Thr Asn His Pro Met Asn 
                1765                1770                1775    
Lys Thr Ser Ala Ser Leu Ser Leu Asp Tyr Leu Leu Gln Gly Thr Asp 
            1780                1785                1790        
Val Val Ile Ala Ile Phe Ile Ile Val Ala Met Ser Phe Val Pro Ala 
        1795                1800                1805            
Ser Phe Val Val Phe Leu Val Ala Glu Lys Ser Thr Lys Ala Lys His 
    1810                1815                1820                
Leu Gln Phe Val Ser Gly Cys Asn Pro Ile Ile Tyr Trp Leu Ala Asn 
1825                1830                1835                1840
Tyr Val Trp Asp Met Leu Asn Tyr Leu Val Pro Ala Thr Cys Cys Val 
                1845                1850                1855    
Ile Ile Leu Phe Val Phe Asp Leu Pro Ala Tyr Thr Ser Pro Thr Asn 
            1860                1865                1870        
Phe Pro Ala Val Leu Ser Leu Phe Leu Leu Tyr Gly Trp Ser Ile Thr 
        1875                1880                1885            
Pro Ile Met Tyr Pro Ala Ser Phe Trp Phe Glu Val Pro Ser Ser Ala 
    1890                1895                1900                
Tyr Val Phe Leu Ile Val Ile Asn Leu Phe Ile Gly Ile Thr Ala Thr 
1905                1910                1915                1920
Val Ala Thr Phe Leu Leu Gln Leu Phe Glu His Asp Lys Asp Leu Lys 
                1925                1930                1935    
Val Val Asn Ser Tyr Leu Lys Ser Cys Phe Leu Ile Phe Pro Asn Tyr 
            1940                1945                1950        
Asn Leu Gly His Gly Leu Met Glu Met Ala Tyr Asn Glu Tyr Ile Asn 
        1955                1960                1965            
Glu Tyr Tyr Ala Lys Ile Gly Gln Phe Asp Lys Met Lys Ser Pro Phe 
    1970                1975                1980                
Glu Trp Asp Ile Val Thr Arg Gly Leu Val Ala Met Ala Val Glu Gly 
1985                1990                1995                2000
Val Val Gly Phe Leu Leu Thr Ile Met Cys Gln Tyr Asn Phe Leu Arg 
                2005                2010                2015    
Arg Pro Gln Arg Met Pro Val Ser Thr Lys Pro Val Glu Asp Asp Val 
            2020                2025                2030        
Asp Val Ala Ser Glu Arg Gln Arg Val Leu Arg Gly Asp Ala Asp Asn 
        2035                2040                2045            
Asp Met Val Lys Ile Glu Asn Leu Thr Lys Val Tyr Lys Ser Arg Lys 
    2050                2055                2060                
Ile Gly Arg Ile Leu Ala Val Asp Arg Leu Cys Leu Gly Val Arg Pro 
2065                2070                2075                2080
Gly Glu Cys Phe Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Ser 
                2085                2090                2095    
Thr Phe Lys Met Leu Thr Gly Asp Glu Ser Thr Thr Gly Gly Glu Ala 
            2100                2105                2110        
Phe Val Asn Gly His Ser Val Leu Lys Glu Leu Leu Gln Val Gln Gln 
        2115                2120                2125            
Ser Leu Gly Tyr Cys Pro Gln Cys Asp Ala Leu Phe Asp Glu Leu Thr 
    2130                2135                2140                
Ala Arg Glu His Leu Gln Leu Tyr Thr Arg Leu Arg Gly Ile Ser Trp 
2145                2150                2155                2160
Lys Asp Glu Ala Arg Val Val Lys Trp Ala Leu Glu Lys Leu Glu Leu 
                2165                2170                2175    
Thr Lys Tyr Ala Asp Lys Pro Ala Gly Thr Tyr Ser Gly Gly Asn Lys 
            2180                2185                2190        
Arg Lys Leu Ser Thr Ala Ile Ala Leu Ile Gly Tyr Pro Ala Phe Ile 
        2195                2200                2205            
Phe Leu Asp Glu Pro Thr Thr Gly Met Asp Pro Lys Ala Arg Arg Phe 
    2210                2215                2220                
Leu Trp Asn Leu Ile Leu Asp Leu Ile Lys Thr Gly Arg Ser Val Val 
2225                2230                2235                2240
Leu Thr Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu 
                2245                2250                2255    
Ala Ile Met Val Asn Gly Arg Leu Arg Cys Leu Gly Ser Ile Gln His 
            2260                2265                2270        
Leu Lys Asn Arg Phe Gly Asp Gly Tyr Met Ile Thr Val Arg Thr Lys 
        2275                2280                2285            
Ser Ser Gln Ser Val Lys Asp Val Val Arg Phe Phe Asn Arg Asn Phe 
    2290                2295                2300                
Pro Glu Ala Met Leu Lys Glu Arg His His Thr Lys Val Gln Tyr Gln 
2305                2310                2315                2320
Leu Lys Ser Glu His Ile Ser Leu Ala Gln Val Phe Ser Lys Met Glu 
                2325                2330                2335    
Gln Val Ser Gly Val Leu Gly Ile Glu Asp Tyr Ser Val Ser Gln Thr 
            2340                2345                2350        
Thr Leu Asp Asn Val Phe Val Asn Phe Ala Lys Lys Gln Ser Asp Asn 
        2355                2360                2365            
Leu Glu Gln Gln Glu Thr Glu Pro Pro Ser Ala Leu Gln Ser Pro Leu 
    2370                2375                2380                
Gly Cys Leu Leu Ser Leu Leu Arg Pro Arg Ser Ala Pro Thr Glu Leu 
2385                2390                2395                2400
Arg Ala Leu Val Ala Asp Glu Pro Glu Asp Leu Asp Thr Glu Asp Glu 
                2405                2410                2415    
Gly Leu Ile Ser Phe Glu Glu Glu Arg Ala Gln Leu Ser Phe Asn Thr 
            2420                2425                2430        
Asp Thr Leu Cys 
        2435    

<210> 5
<211> 6822
<212> DNA
<213> Homo sapiens


<400> 5
atgggcttcg tgagacagat acagcttttg ctctggaaga actggaccct gcggaaaagg       60

caaaagattc gctttgtggt ggaactcgtg tggcctttat ctttatttct ggtcttgatc      120

tggttaagga atgccaaccc actctacagc catcatgaat gccatttccc caacaaggcg      180

atgccctcag caggaatgct gccgtggctc caggggatct tctgcaatgt gaacaatccc      240

tgttttcaaa gccccacccc aggagaatct cctggaattg tgtcaaacta taacaactcc      300

atcttggcaa gggtatatcg agattttcaa gaactcctca tgaatgcacc agagagccag      360

caccttggcc gtatttggac agagctacac atcttgtccc aattcatgga caccctccgg      420

actcacccgg agagaattgc aggaagagga atacgaataa gggatatctt gaaagatgaa      480

gaaacactga cactatttct cattaaaaac atcggcctgt ctgactcagt ggtctacctt      540

ctgatcaact ctcaagtccg tccagagcag ttcgctcatg gagtcccgga cctggcgctg      600

aaggacatcg cctgcagcga ggccctcctg gagcgcttca tcatcttcag ccagagacgc      660

ggggcaaaga cggtgcgcta tgccctgtgc tccctctccc agggcaccct acagtggata      720

gaagacactc tgtatgccaa cgtggacttc ttcaagctct tccgtgtgct tcccacactc      780

ctagacagcc gttctcaagg tatcaatctg agatcttggg gaggaatatt atctgatatg      840

tcaccaagaa ttcaagagtt tatccatcgg ccgagtatgc aggacttgct gtgggtgacc      900

aggcccctca tgcagaatgg tggtccagag acctttacaa agctgatggg catcctgtct      960

gacctcctgt gtggctaccc cgagggaggt ggctctcggg tgctctcctt caactggtat     1020

gaagacaata actataaggc ctttctgggg attgactcca caaggaagga tcctatctat     1080

tcttatgaca gaagaacaac atccttttgt aatgcattga tccagagcct ggagtcaaat     1140

cctttaacca aaatcgcttg gagggcggca aagcctttgc tgatgggaaa aatcctgtac     1200

actcctgatt cacctgcagc acgaaggata ctgaagaatg ccaactcaac ttttgaagaa     1260

ctggaacacg ttaggaagtt ggtcaaagcc tgggaagaag tagggcccca gatctggtac     1320

ttctttgaca acagcacaca gatgaacatg atcagagata ccctggggaa cccaacagta     1380

aaagactttt tgaataggca gcttggtgaa gaaggtatta ctgctgaagc catcctaaac     1440

ttcctctaca agggccctcg ggaaagccag gctgacgaca tggccaactt cgactggagg     1500

gacatattta acatcactga tcgcaccctc cgcctggtca atcaatacct ggagtgcttg     1560

gtcctggata agtttgaaag ctacaatgat gaaactcagc tcacccaacg tgccctctct     1620

ctactggagg aaaacatgtt ctgggccgga gtggtattcc ctgacatgta tccctggacc     1680

agctctctac caccccacgt gaagtataag atccgaatgg acatagacgt ggtggagaaa     1740

accaataaga ttaaagacag gtattgggat tctggtccca gagctgatcc cgtggaagat     1800

ttccggtaca tctggggcgg gtttgcctat ctgcaggaca tggttgaaca ggggatcaca     1860

aggagccagg tgcaggcgga ggctccagtt ggaatctacc tccagcagat gccctacccc     1920

tgcttcgtgg acgattcttt catgatcatc ctgaaccgct gtttccctat cttcatggtg     1980

ctggcatgga tctactctgt ctccatgact gtgaagagca tcgtcttgga gaaggagttg     2040

cgactgaagg agaccttgaa aaatcagggt gtctccaatg cagtgatttg gtgtacctgg     2100

ttcctggaca gcttctccat catgtcgatg agcatcttcc tcctgacgat attcatcatg     2160

catggaagaa tcctacatta cagcgaccca ttcatcctct tcctgttctt gttggctttc     2220

tccactgcca ccatcatgct gtgctttctg ctcagcacct tcttctccaa ggccagtctg     2280

gcagcagcct gtagtggtgt catctatttc accctctacc tgccacacat cctgtgcttc     2340

gcctggcagg accgcatgac cgctgagctg aagaaggctg tgagcttact gtctccggtg     2400

gcatttggat ttggcactga gtacctggtt cgctttgaag agcaaggcct ggggctgcag     2460

tggagcaaca tcgggaacag tcccacggaa ggggacgaat tcagcttcct gctgtccatg     2520

cagatgatgc tccttgatgc tgctgtctat ggcttactcg cttggtacct tgatcaggtg     2580

tttccaggag actatggaac cccacttcct tggtactttc ttctacaaga gtcgtattgg     2640

cttggcggtg aagggtgttc aaccagagaa gaaagagccc tggaaaagac cgagccccta     2700

acagaggaaa cggaggatcc agagcaccca gaaggaatac acgactcctt ctttgaacgt     2760

gagcatccag ggtgggttcc tggggtatgc gtgaagaatc tggtaaagat ttttgagccc     2820

tgtggccggc cagctgtgga ccgtctgaac atcaccttct acgagaacca gatcaccgca     2880

ttcctgggcc acaatggagc tgggaaaacc accaccttgt ccatcctgac gggtctgttg     2940

ccaccaacct ctgggactgt gctcgttggg ggaagggaca ttgaaaccag cctggatgca     3000

gtccggcaga gccttggcat gtgtccacag cacaacatcc tgttccacca cctcacggtg     3060

gctgagcaca tgctgttcta tgcccagctg aaaggaaagt cccaggagga ggcccagctg     3120

gagatggaag ccatgttgga ggacacaggc ctccaccaca agcggaatga agaggctcag     3180

gacctatcag gtggcatgca gagaaagctg tcggttgcca ttgcctttgt gggagatgcc     3240

aaggtggtga ttctggacga acccacctct ggggtggacc cttactcgag acgctcaatc     3300

tgggatctgc tcctgaagta tcgctcaggc agaaccatca tcatgtccac tcaccacatg     3360

gacgaggccg acctccttgg ggaccgcatt gccatcattg cccagggaag gctctactgc     3420

tcaggcaccc cactcttcct gaagaactgc tttggcacag gcttgtactt aaccttggtg     3480

cgcaagatga aaaacatcca gagccaaagg aaaggcagtg aggggacctg cagctgctcg     3540

tctaagggtt tctccaccac gtgtccagcc cacgtcgatg acctaactcc agaacaagtc     3600

ctggatgggg atgtaaatga gctgatggat gtagttctcc accatgttcc agaggcaaag     3660

ctggtggagt gcattggtca agaacttatc ttccttcttc caaataagaa cttcaagcac     3720

agagcatatg ccagcctttt cagagagctg gaggagacgc tggctgacct tggtctcagc     3780

agttttggaa tttctgacac tcccctggaa gagatttttc tgaaggtcac ggaggattct     3840

gattcaggac ctctgtttgc gggtggcgct cagcagaaaa gagaaaacgt caacccccga     3900

cacccctgct tgggtcccag agagaaggct ggacagacac cccaggactc caatgtctgc     3960

tccccagggg cgccggctgc tcacccagag ggccagcctc ccccagagcc agagtgccca     4020

ggcccgcagc tcaacacggg gacacagctg gtcctccagc atgtgcaggc gctgctggtc     4080

aagagattcc aacacaccat ccgcagccac aaggacttcc tggcgcagat cgtgctcccg     4140

gctacctttg tgtttttggc tctgatgctt tctattgtta tccctccttt tggcgaatac     4200

cccgctttga cccttcaccc ctggatatat gggcagcagt acaccttctt cagcatggat     4260

gaaccaggca gtgagcagtt cacggtactt gcagacgtcc tcctgaataa gccaggcttt     4320

ggcaaccgct gcctgaagga agggtggctt ccggagtacc cctgtggcaa ctcaacaccc     4380

tggaagactc cttctgtgtc cccaaacatc acccagctgt tccagaagca gaaatggaca     4440

caggtcaacc cttcaccatc ctgcaggtgc agcaccaggg agaagctcac catgctgcca     4500

gagtgccccg agggtgccgg gggcctcccg cccccccaga gaacacagcg cagcacggaa     4560

attctacaag acctgacgga caggaacatc tccgacttct tggtaaaaac gtatcctgct     4620

cttataagaa gcagcttaaa gagcaaattc tgggtcaatg aacagaggta tggaggaatt     4680

tccattggag gaaagctccc agtcgtcccc atcacggggg aagcacttgt tgggttttta     4740

agcgaccttg gccggatcat gaatgtgagc gggggcccta tcactagaga ggcctctaaa     4800

gaaatacctg atttccttaa acatctagaa actgaagaca acattaaggt gtggtttaat     4860

aacaaaggct ggcatgccct ggtcagcttt ctcaatgtgg cccacaacgc catcttacgg     4920

gccagcctgc ctaaggacag gagccccgag gagtatggaa tcaccgtcat tagccaaccc     4980

ctgaacctga ccaaggagca gctctcagag attacagtgc tgaccacttc agtggatgct     5040

gtggttgcca tctgcgtgat tttctccatg tccttcgtcc cagccagctt tgtcctttat     5100

ttgatccagg agcgggtgaa caaatccaag cacctccagt ttatcagtgg agtgagcccc     5160

accacctact gggtgaccaa cttcctctgg gacatcatga attattccgt gagtgctggg     5220

ctggtggtgg gcatcttcat cgggtttcag aagaaagcct acacttctcc agaaaacctt     5280

cctgcccttg tggcactgct cctgctgtat ggatgggcgg tcattcccat gatgtaccca     5340

gcatccttcc tgtttgatgt ccccagcaca gcctatgtgg ctttatcttg tgctaatctg     5400

ttcatcggca tcaacagcag tgctattacc ttcatcttgg aattatttga gaataaccgg     5460

acgctgctca ggttcaacgc cgtgctgagg aagctgctca ttgtcttccc ccacttctgc     5520

ctgggccggg gcctcattga ccttgcactg agccaggctg tgacagatgt ctatgcccgg     5580

tttggtgagg agcactctgc aaatccgttc cactgggacc tgattgggaa gaacctgttt     5640

gccatggtgg tggaaggggt ggtgtacttc ctcctgaccc tgctggtcca gcgccacttc     5700

ttcctctccc aatggattgc cgagcccact aaggagccca ttgttgatga agatgatgat     5760

gtggctgaag aaagacaaag aattattact ggtggaaata aaactgacat cttaaggcta     5820

catgaactaa ccaagattta tccaggcacc tccagcccag cagtggacag gctgtgtgtc     5880

ggagttcgcc ctggagagtg ctttggcctc ctgggagtga atggtgccgg caaaacaacc     5940

acattcaaga tgctcactgg ggacaccaca gtgacctcag gggatgccac cgtagcaggc     6000

aagagtattt taaccaatat ttctgaagtc catcaaaata tgggctactg tcctcagttt     6060

gatgcaattg atgagctgct cacaggacga gaacatcttt acctttatgc ccggcttcga     6120

ggtgtaccag cagaagaaat cgaaaaggtt gcaaactgga gtattaagag cctgggcctg     6180

actgtctacg ccgactgcct ggctggcacg tacagtgggg gcaacaagcg gaaactctcc     6240

acagccatcg cactcattgg ctgcccaccg ctggtgctgc tggatgagcc caccacaggg     6300

atggaccccc aggcacgccg catgctgtgg aacgtcatcg tgagcatcat cagagaaggg     6360

agggctgtgg tcctcacatc ccacagcatg gaagaatgtg aggcactgtg tacccggctg     6420

gccatcatgg taaagggcgc ctttcgatgt atgggcacca ttcagcatct caagtccaaa     6480

tttggagatg gctatatcgt cacaatgaag atcaaatccc cgaaggacga cctgcttcct     6540

gacctgaacc ctgtggagca gttcttccag gggaacttcc caggcagtgt gcagagggag     6600

aggcactaca acatgctcca gttccaggtc tcctcctcct ccctggcgag gatcttccag     6660

ctcctcctct cccacaagga cagcctgctc atcgaggagt actcagtcac acagaccaca     6720

ctggaccagg tgtttgtaaa ttttgctaaa cagcagactg aaagtcatga cctccctctg     6780

caccctcgag ctgctggagc cagtcgacaa gcccaggact ga                        6822


<210> 6
<211> 2273
<212> PRT
<213> Homo sapiens


<400> 6
Met Gly Phe Val Arg Gln Ile Gln Leu Leu Leu Trp Lys Asn Trp Thr 
1               5                   10                  15      
Leu Arg Lys Arg Gln Lys Ile Arg Phe Val Val Glu Leu Val Trp Pro 
            20                  25                  30          
Leu Ser Leu Phe Leu Val Leu Ile Trp Leu Arg Asn Ala Asn Pro Leu 
        35                  40                  45              
Tyr Ser His His Glu Cys His Phe Pro Asn Lys Ala Met Pro Ser Ala 
    50                  55                  60                  
Gly Met Leu Pro Trp Leu Gln Gly Ile Phe Cys Asn Val Asn Asn Pro 
65                  70                  75                  80  
Cys Phe Gln Ser Pro Thr Pro Gly Glu Ser Pro Gly Ile Val Ser Asn 
                85                  90                  95      
Tyr Asn Asn Ser Ile Leu Ala Arg Val Tyr Arg Asp Phe Gln Glu Leu 
            100                 105                 110         
Leu Met Asn Ala Pro Glu Ser Gln His Leu Gly Arg Ile Trp Thr Glu 
        115                 120                 125             
Leu His Ile Leu Ser Gln Phe Met Asp Thr Leu Arg Thr His Pro Glu 
    130                 135                 140                 
Arg Ile Ala Gly Arg Gly Ile Arg Ile Arg Asp Ile Leu Lys Asp Glu 
145                 150                 155                 160 
Glu Thr Leu Thr Leu Phe Leu Ile Lys Asn Ile Gly Leu Ser Asp Ser 
                165                 170                 175     
Val Val Tyr Leu Leu Ile Asn Ser Gln Val Arg Pro Glu Gln Phe Ala 
            180                 185                 190         
His Gly Val Pro Asp Leu Ala Leu Lys Asp Ile Ala Cys Ser Glu Ala 
        195                 200                 205             
Leu Leu Glu Arg Phe Ile Ile Phe Ser Gln Arg Arg Gly Ala Lys Thr 
    210                 215                 220                 
Val Arg Tyr Ala Leu Cys Ser Leu Ser Gln Gly Thr Leu Gln Trp Ile 
225                 230                 235                 240 
Glu Asp Thr Leu Tyr Ala Asn Val Asp Phe Phe Lys Leu Phe Arg Val 
                245                 250                 255     
Leu Pro Thr Leu Leu Asp Ser Arg Ser Gln Gly Ile Asn Leu Arg Ser 
            260                 265                 270         
Trp Gly Gly Ile Leu Ser Asp Met Ser Pro Arg Ile Gln Glu Phe Ile 
        275                 280                 285             
His Arg Pro Ser Met Gln Asp Leu Leu Trp Val Thr Arg Pro Leu Met 
    290                 295                 300                 
Gln Asn Gly Gly Pro Glu Thr Phe Thr Lys Leu Met Gly Ile Leu Ser 
305                 310                 315                 320 
Asp Leu Leu Cys Gly Tyr Pro Glu Gly Gly Gly Ser Arg Val Leu Ser 
                325                 330                 335     
Phe Asn Trp Tyr Glu Asp Asn Asn Tyr Lys Ala Phe Leu Gly Ile Asp 
            340                 345                 350         
Ser Thr Arg Lys Asp Pro Ile Tyr Ser Tyr Asp Arg Arg Thr Thr Ser 
        355                 360                 365             
Phe Cys Asn Ala Leu Ile Gln Ser Leu Glu Ser Asn Pro Leu Thr Lys 
    370                 375                 380                 
Ile Ala Trp Arg Ala Ala Lys Pro Leu Leu Met Gly Lys Ile Leu Tyr 
385                 390                 395                 400 
Thr Pro Asp Ser Pro Ala Ala Arg Arg Ile Leu Lys Asn Ala Asn Ser 
                405                 410                 415     
Thr Phe Glu Glu Leu Glu His Val Arg Lys Leu Val Lys Ala Trp Glu 
            420                 425                 430         
Glu Val Gly Pro Gln Ile Trp Tyr Phe Phe Asp Asn Ser Thr Gln Met 
        435                 440                 445             
Asn Met Ile Arg Asp Thr Leu Gly Asn Pro Thr Val Lys Asp Phe Leu 
    450                 455                 460                 
Asn Arg Gln Leu Gly Glu Glu Gly Ile Thr Ala Glu Ala Ile Leu Asn 
465                 470                 475                 480 
Phe Leu Tyr Lys Gly Pro Arg Glu Ser Gln Ala Asp Asp Met Ala Asn 
                485                 490                 495     
Phe Asp Trp Arg Asp Ile Phe Asn Ile Thr Asp Arg Thr Leu Arg Leu 
            500                 505                 510         
Val Asn Gln Tyr Leu Glu Cys Leu Val Leu Asp Lys Phe Glu Ser Tyr 
        515                 520                 525             
Asn Asp Glu Thr Gln Leu Thr Gln Arg Ala Leu Ser Leu Leu Glu Glu 
    530                 535                 540                 
Asn Met Phe Trp Ala Gly Val Val Phe Pro Asp Met Tyr Pro Trp Thr 
545                 550                 555                 560 
Ser Ser Leu Pro Pro His Val Lys Tyr Lys Ile Arg Met Asp Ile Asp 
                565                 570                 575     
Val Val Glu Lys Thr Asn Lys Ile Lys Asp Arg Tyr Trp Asp Ser Gly 
            580                 585                 590         
Pro Arg Ala Asp Pro Val Glu Asp Phe Arg Tyr Ile Trp Gly Gly Phe 
        595                 600                 605             
Ala Tyr Leu Gln Asp Met Val Glu Gln Gly Ile Thr Arg Ser Gln Val 
    610                 615                 620                 
Gln Ala Glu Ala Pro Val Gly Ile Tyr Leu Gln Gln Met Pro Tyr Pro 
625                 630                 635                 640 
Cys Phe Val Asp Asp Ser Phe Met Ile Ile Leu Asn Arg Cys Phe Pro 
                645                 650                 655     
Ile Phe Met Val Leu Ala Trp Ile Tyr Ser Val Ser Met Thr Val Lys 
            660                 665                 670         
Ser Ile Val Leu Glu Lys Glu Leu Arg Leu Lys Glu Thr Leu Lys Asn 
        675                 680                 685             
Gln Gly Val Ser Asn Ala Val Ile Trp Cys Thr Trp Phe Leu Asp Ser 
    690                 695                 700                 
Phe Ser Ile Met Ser Met Ser Ile Phe Leu Leu Thr Ile Phe Ile Met 
705                 710                 715                 720 
His Gly Arg Ile Leu His Tyr Ser Asp Pro Phe Ile Leu Phe Leu Phe 
                725                 730                 735     
Leu Leu Ala Phe Ser Thr Ala Thr Ile Met Leu Cys Phe Leu Leu Ser 
            740                 745                 750         
Thr Phe Phe Ser Lys Ala Ser Leu Ala Ala Ala Cys Ser Gly Val Ile 
        755                 760                 765             
Tyr Phe Thr Leu Tyr Leu Pro His Ile Leu Cys Phe Ala Trp Gln Asp 
    770                 775                 780                 
Arg Met Thr Ala Glu Leu Lys Lys Ala Val Ser Leu Leu Ser Pro Val 
785                 790                 795                 800 
Ala Phe Gly Phe Gly Thr Glu Tyr Leu Val Arg Phe Glu Glu Gln Gly 
                805                 810                 815     
Leu Gly Leu Gln Trp Ser Asn Ile Gly Asn Ser Pro Thr Glu Gly Asp 
            820                 825                 830         
Glu Phe Ser Phe Leu Leu Ser Met Gln Met Met Leu Leu Asp Ala Ala 
        835                 840                 845             
Val Tyr Gly Leu Leu Ala Trp Tyr Leu Asp Gln Val Phe Pro Gly Asp 
    850                 855                 860                 
Tyr Gly Thr Pro Leu Pro Trp Tyr Phe Leu Leu Gln Glu Ser Tyr Trp 
865                 870                 875                 880 
Leu Gly Gly Glu Gly Cys Ser Thr Arg Glu Glu Arg Ala Leu Glu Lys 
                885                 890                 895     
Thr Glu Pro Leu Thr Glu Glu Thr Glu Asp Pro Glu His Pro Glu Gly 
            900                 905                 910         
Ile His Asp Ser Phe Phe Glu Arg Glu His Pro Gly Trp Val Pro Gly 
        915                 920                 925             
Val Cys Val Lys Asn Leu Val Lys Ile Phe Glu Pro Cys Gly Arg Pro 
    930                 935                 940                 
Ala Val Asp Arg Leu Asn Ile Thr Phe Tyr Glu Asn Gln Ile Thr Ala 
945                 950                 955                 960 
Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Leu Ser Ile Leu 
                965                 970                 975     
Thr Gly Leu Leu Pro Pro Thr Ser Gly Thr Val Leu Val Gly Gly Arg 
            980                 985                 990         
Asp Ile Glu Thr Ser Leu Asp Ala Val Arg Gln Ser Leu Gly Met Cys 
        995                 1000                1005            
Pro Gln His Asn Ile Leu Phe His His Leu Thr Val Ala Glu His Met 
    1010                1015                1020                
Leu Phe Tyr Ala Gln Leu Lys Gly Lys Ser Gln Glu Glu Ala Gln Leu 
1025                1030                1035                1040
Glu Met Glu Ala Met Leu Glu Asp Thr Gly Leu His His Lys Arg Asn 
                1045                1050                1055    
Glu Glu Ala Gln Asp Leu Ser Gly Gly Met Gln Arg Lys Leu Ser Val 
            1060                1065                1070        
Ala Ile Ala Phe Val Gly Asp Ala Lys Val Val Ile Leu Asp Glu Pro 
        1075                1080                1085            
Thr Ser Gly Val Asp Pro Tyr Ser Arg Arg Ser Ile Trp Asp Leu Leu 
    1090                1095                1100                
Leu Lys Tyr Arg Ser Gly Arg Thr Ile Ile Met Ser Thr His His Met 
1105                1110                1115                1120
Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ala Gln Gly 
                1125                1130                1135    
Arg Leu Tyr Cys Ser Gly Thr Pro Leu Phe Leu Lys Asn Cys Phe Gly 
            1140                1145                1150        
Thr Gly Leu Tyr Leu Thr Leu Val Arg Lys Met Lys Asn Ile Gln Ser 
        1155                1160                1165            
Gln Arg Lys Gly Ser Glu Gly Thr Cys Ser Cys Ser Ser Lys Gly Phe 
    1170                1175                1180                
Ser Thr Thr Cys Pro Ala His Val Asp Asp Leu Thr Pro Glu Gln Val 
1185                1190                1195                1200
Leu Asp Gly Asp Val Asn Glu Leu Met Asp Val Val Leu His His Val 
                1205                1210                1215    
Pro Glu Ala Lys Leu Val Glu Cys Ile Gly Gln Glu Leu Ile Phe Leu 
            1220                1225                1230        
Leu Pro Asn Lys Asn Phe Lys His Arg Ala Tyr Ala Ser Leu Phe Arg 
        1235                1240                1245            
Glu Leu Glu Glu Thr Leu Ala Asp Leu Gly Leu Ser Ser Phe Gly Ile 
    1250                1255                1260                
Ser Asp Thr Pro Leu Glu Glu Ile Phe Leu Lys Val Thr Glu Asp Ser 
1265                1270                1275                1280
Asp Ser Gly Pro Leu Phe Ala Gly Gly Ala Gln Gln Lys Arg Glu Asn 
                1285                1290                1295    
Val Asn Pro Arg His Pro Cys Leu Gly Pro Arg Glu Lys Ala Gly Gln 
            1300                1305                1310        
Thr Pro Gln Asp Ser Asn Val Cys Ser Pro Gly Ala Pro Ala Ala His 
        1315                1320                1325            
Pro Glu Gly Gln Pro Pro Pro Glu Pro Glu Cys Pro Gly Pro Gln Leu 
    1330                1335                1340                
Asn Thr Gly Thr Gln Leu Val Leu Gln His Val Gln Ala Leu Leu Val 
1345                1350                1355                1360
Lys Arg Phe Gln His Thr Ile Arg Ser His Lys Asp Phe Leu Ala Gln 
                1365                1370                1375    
Ile Val Leu Pro Ala Thr Phe Val Phe Leu Ala Leu Met Leu Ser Ile 
            1380                1385                1390        
Val Ile Pro Pro Phe Gly Glu Tyr Pro Ala Leu Thr Leu His Pro Trp 
        1395                1400                1405            
Ile Tyr Gly Gln Gln Tyr Thr Phe Phe Ser Met Asp Glu Pro Gly Ser 
    1410                1415                1420                
Glu Gln Phe Thr Val Leu Ala Asp Val Leu Leu Asn Lys Pro Gly Phe 
1425                1430                1435                1440
Gly Asn Arg Cys Leu Lys Glu Gly Trp Leu Pro Glu Tyr Pro Cys Gly 
                1445                1450                1455    
Asn Ser Thr Pro Trp Lys Thr Pro Ser Val Ser Pro Asn Ile Thr Gln 
            1460                1465                1470        
Leu Phe Gln Lys Gln Lys Trp Thr Gln Val Asn Pro Ser Pro Ser Cys 
        1475                1480                1485            
Arg Cys Ser Thr Arg Glu Lys Leu Thr Met Leu Pro Glu Cys Pro Glu 
    1490                1495                1500                
Gly Ala Gly Gly Leu Pro Pro Pro Gln Arg Thr Gln Arg Ser Thr Glu 
1505                1510                1515                1520
Ile Leu Gln Asp Leu Thr Asp Arg Asn Ile Ser Asp Phe Leu Val Lys 
                1525                1530                1535    
Thr Tyr Pro Ala Leu Ile Arg Ser Ser Leu Lys Ser Lys Phe Trp Val 
            1540                1545                1550        
Asn Glu Gln Arg Tyr Gly Gly Ile Ser Ile Gly Gly Lys Leu Pro Val 
        1555                1560                1565            
Val Pro Ile Thr Gly Glu Ala Leu Val Gly Phe Leu Ser Asp Leu Gly 
    1570                1575                1580                
Arg Ile Met Asn Val Ser Gly Gly Pro Ile Thr Arg Glu Ala Ser Lys 
1585                1590                1595                1600
Glu Ile Pro Asp Phe Leu Lys His Leu Glu Thr Glu Asp Asn Ile Lys 
                1605                1610                1615    
Val Trp Phe Asn Asn Lys Gly Trp His Ala Leu Val Ser Phe Leu Asn 
            1620                1625                1630        
Val Ala His Asn Ala Ile Leu Arg Ala Ser Leu Pro Lys Asp Arg Ser 
        1635                1640                1645            
Pro Glu Glu Tyr Gly Ile Thr Val Ile Ser Gln Pro Leu Asn Leu Thr 
    1650                1655                1660                
Lys Glu Gln Leu Ser Glu Ile Thr Val Leu Thr Thr Ser Val Asp Ala 
1665                1670                1675                1680
Val Val Ala Ile Cys Val Ile Phe Ser Met Ser Phe Val Pro Ala Ser 
                1685                1690                1695    
Phe Val Leu Tyr Leu Ile Gln Glu Arg Val Asn Lys Ser Lys His Leu 
            1700                1705                1710        
Gln Phe Ile Ser Gly Val Ser Pro Thr Thr Tyr Trp Val Thr Asn Phe 
        1715                1720                1725            
Leu Trp Asp Ile Met Asn Tyr Ser Val Ser Ala Gly Leu Val Val Gly 
    1730                1735                1740                
Ile Phe Ile Gly Phe Gln Lys Lys Ala Tyr Thr Ser Pro Glu Asn Leu 
1745                1750                1755                1760
Pro Ala Leu Val Ala Leu Leu Leu Leu Tyr Gly Trp Ala Val Ile Pro 
                1765                1770                1775    
Met Met Tyr Pro Ala Ser Phe Leu Phe Asp Val Pro Ser Thr Ala Tyr 
            1780                1785                1790        
Val Ala Leu Ser Cys Ala Asn Leu Phe Ile Gly Ile Asn Ser Ser Ala 
        1795                1800                1805            
Ile Thr Phe Ile Leu Glu Leu Phe Glu Asn Asn Arg Thr Leu Leu Arg 
    1810                1815                1820                
Phe Asn Ala Val Leu Arg Lys Leu Leu Ile Val Phe Pro His Phe Cys 
1825                1830                1835                1840
Leu Gly Arg Gly Leu Ile Asp Leu Ala Leu Ser Gln Ala Val Thr Asp 
                1845                1850                1855    
Val Tyr Ala Arg Phe Gly Glu Glu His Ser Ala Asn Pro Phe His Trp 
            1860                1865                1870        
Asp Leu Ile Gly Lys Asn Leu Phe Ala Met Val Val Glu Gly Val Val 
        1875                1880                1885            
Tyr Phe Leu Leu Thr Leu Leu Val Gln Arg His Phe Phe Leu Ser Gln 
    1890                1895                1900                
Trp Ile Ala Glu Pro Thr Lys Glu Pro Ile Val Asp Glu Asp Asp Asp 
1905                1910                1915                1920
Val Ala Glu Glu Arg Gln Arg Ile Ile Thr Gly Gly Asn Lys Thr Asp 
                1925                1930                1935    
Ile Leu Arg Leu His Glu Leu Thr Lys Ile Tyr Pro Gly Thr Ser Ser 
            1940                1945                1950        
Pro Ala Val Asp Arg Leu Cys Val Gly Val Arg Pro Gly Glu Cys Phe 
        1955                1960                1965            
Gly Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Thr Phe Lys Met 
    1970                1975                1980                
Leu Thr Gly Asp Thr Thr Val Thr Ser Gly Asp Ala Thr Val Ala Gly 
1985                1990                1995                2000
Lys Ser Ile Leu Thr Asn Ile Ser Glu Val His Gln Asn Met Gly Tyr 
                2005                2010                2015    
Cys Pro Gln Phe Asp Ala Ile Asp Glu Leu Leu Thr Gly Arg Glu His 
            2020                2025                2030        
Leu Tyr Leu Tyr Ala Arg Leu Arg Gly Val Pro Ala Glu Glu Ile Glu 
        2035                2040                2045            
Lys Val Ala Asn Trp Ser Ile Lys Ser Leu Gly Leu Thr Val Tyr Ala 
    2050                2055                2060                
Asp Cys Leu Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser 
2065                2070                2075                2080
Thr Ala Ile Ala Leu Ile Gly Cys Pro Pro Leu Val Leu Leu Asp Glu 
                2085                2090                2095    
Pro Thr Thr Gly Met Asp Pro Gln Ala Arg Arg Met Leu Trp Asn Val 
            2100                2105                2110        
Ile Val Ser Ile Ile Arg Glu Gly Arg Ala Val Val Leu Thr Ser His 
        2115                2120                2125            
Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val 
    2130                2135                2140                
Lys Gly Ala Phe Arg Cys Met Gly Thr Ile Gln His Leu Lys Ser Lys 
2145                2150                2155                2160
Phe Gly Asp Gly Tyr Ile Val Thr Met Lys Ile Lys Ser Pro Lys Asp 
                2165                2170                2175    
Asp Leu Leu Pro Asp Leu Asn Pro Val Glu Gln Phe Phe Gln Gly Asn 
            2180                2185                2190        
Phe Pro Gly Ser Val Gln Arg Glu Arg His Tyr Asn Met Leu Gln Phe 
        2195                2200                2205            
Gln Val Ser Ser Ser Ser Leu Ala Arg Ile Phe Gln Leu Leu Leu Ser 
    2210                2215                2220                
His Lys Asp Ser Leu Leu Ile Glu Glu Tyr Ser Val Thr Gln Thr Thr 
2225                2230                2235                2240
Leu Asp Gln Val Phe Val Asn Phe Ala Lys Gln Gln Thr Glu Ser His 
                2245                2250                2255    
Asp Leu Pro Leu His Pro Arg Ala Ala Gly Ala Ser Arg Gln Ala Gln 
            2260                2265                2270        
Asp 
    

<210> 7
<211> 6441
<212> DNA
<213> Homo sapiens


<400> 7
atggccttct ggacacagct gatgctgctg ctctggaaga atttcatgta tcgccggaga       60

cagccggtcc agctcctggt cgaattgctg tggcctctct tcctcttctt catcctggtg      120

gctgttcgcc actcccaccc gcccctggag caccatgaat gccacttccc aaacaagcca      180

ctgccatcgg cgggcaccgt gccctggctc cagggtctca tctgtaatgt gaacaacacc      240

tgctttccgc agctgacacc gggcgaggag cccgggcgcc tgagcaactt caacgactcc      300

ctggtctccc ggctgctagc cgatgcccgc actgtgctgg gaggggccag tgcccacagg      360

acgctggctg gcctagggaa gctgatcgcc acgctgaggg ctgcacgcag cacggcccag      420

cctcaaccaa ccaagcagtc tccactggaa ccacccatgc tggatgtcgc ggagctgctg      480

acgtcactgc tgcgcacgga atccctgggg ttggcactgg gccaagccca ggagcccttg      540

cacagcttgt tggaggccgc tgaggacctg gcccaggagc tcctggcgct gcgcagcctg      600

gtggagcttc gggcactgct gcagagaccc cgagggacca gcggccccct ggagttgctg      660

tcagaggccc tctgcagtgt caggggacct agcagcacag tgggcccctc cctcaactgg      720

tacgaggcta gtgacctgat ggagctggtg gggcaggagc cagaatccgc cctgccagac      780

agcagcctga gccccgcctg ctcggagctg attggagccc tggacagcca cccgctgtcc      840

cgcctgctct ggagacgcct gaagcctctg atcctcggga agctactctt tgcaccagat      900

acacctttta cccggaagct catggcccag gtgaaccgga ccttcgagga gctcaccctg      960

ctgagggatg tccgggaggt gtgggagatg ctgggacccc ggatcttcac cttcatgaac     1020

gacagttcca atgtggccat gctgcagcgg ctcctgcaga tgcaggatga aggaagaagg     1080

cagcccagac ctggaggccg ggaccacatg gaggccctgc gatcctttct ggaccctggg     1140

agcggtggct acagctggca ggacgcacac gctgatgtgg ggcacctggt gggcacgctg     1200

ggccgagtga cggagtgcct gtccttggac aagctggagg cggcaccctc agaggcagcc     1260

ctggtgtcgc gggccctgca actgctcgcg gaacatcgat tctgggccgg cgtcgtcttc     1320

ttgggacctg aggactcttc agaccccaca gagcacccaa ccccagacct gggccccggc     1380

cacgtgcgca tcaaaatccg catggacatt gacgtggtca cgaggaccaa taagatcagg     1440

gacaggtttt gggaccctgg cccagccgcg gaccccctga ccgacctgcg ctacgtgtgg     1500

ggcggcttcg tgtacctgca agacctggtg gagcgtgcag ccgtccgcgt gctcagcggc     1560

gccaaccccc gggccggcct ctacctgcag cagatgccct atccgtgcta tgtggacgac     1620

gtgttcctgc gtgtgctgag ccggtcgctg ccgctcttcc tgacgctggc ctggatctac     1680

tccgtgacac tgacagtgaa ggccgtggtg cgggagaagg agacgcggct gcgggacacc     1740

atgcgcgcca tggggctcag ccgcgcggtg ctctggctag gctggttcct cagctgcctc     1800

gggcccttcc tgctcagcgc cgcactgctg gttctggtgc tcaagctggg agacatcctc     1860

ccctacagcc acccgggcgt ggtcttcctg ttcttggcag ccttcgcggt ggccacggtg     1920

acccagagct tcctgctcag cgccttcttc tcccgcgcca acctggctgc ggcctgcggc     1980

ggcctggcct acttctccct ctacctgccc tacgtgctgt gtgtggcttg gcgggaccgg     2040

ctgcccgcgg gtggccgcgt ggccgcgagc ctgctgtcgc ccgtggcctt cggcttcggc     2100

tgcgagagcc tggctctgct ggaggagcag ggcgagggcg cgcagtggca caacgtgggc     2160

acccggccta cggcagacgt cttcagcctg gcccaggtct ctggccttct gctgctggac     2220

gcggcgctct acggcctcgc cacctggtac ctggaagctg tgtgcccagg ccagtacggg     2280

atccctgaac catggaattt tccttttcgg aggagctact ggtgcggacc tcggcccccc     2340

aagagtccag ccccttgccc caccccgctg gacccaaagg tgctggtaga agaggcaccg     2400

cccggcctga gtcctggcgt ctccgttcgc agcctggaga agcgctttcc tggaagcccg     2460

cagccagccc tgcgggggct cagcctggac ttctaccagg gccacatcac cgccttcctg     2520

ggccacaacg gggccggcaa gaccaccacc ctgtccatct tgagtggcct cttcccaccc     2580

agtggtggct ctgccttcat cctgggccac gacgtccgct ccagcatggc cgccatccgg     2640

ccccacctgg gcgtctgtcc tcagtacaac gtgctgtttg acatgctgac cgtggacgag     2700

cacgtctggt tctatgggcg gctgaagggt ctgagtgccg ctgtagtggg ccccgagcag     2760

gaccgtctgc tgcaggatgt ggggctggtc tccaagcaga gtgtgcagac tcgccacctc     2820

tctggtggga tgcaacggaa gctgtccgtg gccattgcct ttgtgggcgg ctcccaagtt     2880

gttatcctgg acgagcctac ggctggcgtg gatcctgctt cccgccgcgg tatttgggag     2940

ctgctgctca aataccgaga aggtcgcacg ctgatcctct ccacccacca cctggatgag     3000

gcagagctgc tgggagaccg tgtggccgtg gtggcaggtg gccgcttgtg ctgctgtggc     3060

tccccactct tcctgcgccg tcacctgggc tccggctact acctgacgct ggtgaaggcc     3120

cgcctgcccc tgaccaccaa tgagaaggct gacactgaca tggagggcag tgtggacacc     3180

aggcaggaaa agaagaatgg cagccagggc agcagagtcg gcactcctca gctgctggcc     3240

ctggtacagc actgggtgcc cggggcacgg ctggtggagg agctgccaca cgagctggtg     3300

ctggtgctgc cctacacggg tgcccatgac ggcagcttcg ccacactctt ccgagagcta     3360

gacacgcggc tggcggagct gaggctcact ggctacggga tctccgacac cagcctcgag     3420

gagatcttcc tgaaggtggt ggaggagtgt gctgcggaca cagatatgga ggatggcagc     3480

tgcgggcagc acctatgcac aggcattgct ggcctagacg taaccctacg gctcaagatg     3540

ccgccacagg agacagcgct ggagaacggg gaaccagctg ggtcagcccc agagactgac     3600

cagggctctg ggccagacgc cgtgggccgg gtacagggct gggcactgac ccgccagcag     3660

ctccaggccc tgcttctcaa gcgctttctg cttgcccgcc gcagccgccg cggcctgttc     3720

gcccagatcg tgctgcctgc cctctttgtg ggcctggccc tcgtgttcag cctcatcgtg     3780

cctcctttcg ggcactaccc ggctctgcgg ctcagtccca ccatgtacgg tgctcaggtg     3840

tccttcttca gtgaggacgc cccaggggac cctggacgtg cccggctgct cgaggcgctg     3900

ctgcaggagg caggactgga ggagccccca gtgcagcata gctcccacag gttctcggca     3960

ccagaagttc ctgctgaagt ggccaaggtc ttggccagtg gcaactggac cccagagtct     4020

ccatccccag cctgccagtg tagccggccc ggtgcccggc gcctgctgcc cgactgcccg     4080

gctgcagctg gtggtccccc tccgccccag gcagtgaccg gctctgggga agtggttcag     4140

aacctgacag gccggaacct gtctgacttc ctggtcaaga cctacccgcg cctggtgcgc     4200

cagggcctga agactaagaa gtgggtgaat gaggtcagat acggaggctt ctcgctgggg     4260

ggccgagacc caggcctgcc ctcgggccaa gagttgggcc gctcagtgga ggagttgtgg     4320

gcgctgctga gtcccctgcc tggcggggcc ctcgaccgtg tcctgaaaaa cctcacagcc     4380

tgggctcaca gcctggatgc tcaggacagt ctcaagatct ggttcaacaa caaaggctgg     4440

cactccatgg tggcctttgt caaccgagcc agcaacgcaa tcctccgtgc tcacctgccc     4500

ccaggcccgg cccgccacgc ccacagcatc accacactca accacccctt gaacctcacc     4560

aaggagcagc tgtctgaggg tgcactgatg gcctcctcgg tggacgtcct cgtctccatc     4620

tgtgtggtct ttgccatgtc ctttgtcccg gccagcttca ctcttgtcct cattgaggag     4680

cgagtcaccc gagccaagca cctgcagctc atggggggcc tgtcccccac cctctactgg     4740

cttggcaact ttctctggga catgtgtaac tacttggtgc cagcatgcat cgtggtgctc     4800

atctttctgg ccttccagca gagggcatat gtggcccctg ccaacctgcc tgctctcctg     4860

ctgttgctac tactgtatgg ctggtcgatc acaccgctca tgtacccagc ctccttcttc     4920

ttctccgtgc ccagcacagc ctatgtggtg ctcacctgca taaacctctt tattggcatc     4980

aatggaagca tggccacctt tgtgcttgag ctcttctctg atcagaagct gcaggaggtg     5040

agccggatct tgaaacaggt cttccttatc ttcccccact tctgcttggg ccgggggctc     5100

attgacatgg tgcggaacca ggccatggct gatgcctttg agcgcttggg agacaggcag     5160

ttccagtcac ccctgcgctg ggaggtggtc ggcaagaacc tcttggccat ggtgatacag     5220

gggcccctct tccttctctt cacactactg ctgcagcacc gaagccaact cctgccacag     5280

cccagggtga ggtctctgcc actcctggga gaggaggacg aggatgtagc ccgtgaacgg     5340

gagcgggtgg tccaaggagc cacccagggg gatgtgttgg tgctgaggaa cttgaccaag     5400

gtataccgtg ggcagaggat gccagctgtt gaccgcttgt gcctggggat tccccctggt     5460

gagtgttttg ggctgctggg tgtgaatgga gcagggaaga cgtccacgtt tcgcatggtg     5520

acgggggaca cattggccag caggggcgag gctgtgctgg caggccacag cgtggcccgg     5580

gaacccagtg ctgcgcacct cagcatggga tactgccctc aatccgatgc catctttgag     5640

ctgctgacgg gccgcgagca cctggagctg cttgcgcgcc tgcgcggtgt cccggaggcc     5700

caggttgccc agaccgctgg ctcgggcctg gcgcgtctgg gactctcatg gtacgcagac     5760

cggcctgcag gcacctacag cggagggaac aaacgcaagc tggcgacggc cctggcgctg     5820

gttggggacc cagccgtggt gtttctggac gagccgacca caggcatgga ccccagcgcg     5880

cggcgcttcc tttggaacag ccttttggcc gtggtgcggg agggccgttc agtgatgctc     5940

acctcccata gcatggagga gtgtgaagcg ctctgctcgc gcctggccat catggtgaat     6000

gggcggttcc gctgcctggg cagcccgcaa catctcaagg gcagattcgc ggcgggtcac     6060

acactgaccc tgcgggtgcc cgccgcaagg tcccagccgg cagcggcctt cgtggcggcc     6120

gagttccctg gggcggagct gcgcgaggca catggaggcc gcctgcgctt ccagctgccg     6180

ccgggagggc gctgcgccct ggcgcgcgtc tttggagagc tggcggtgca cggcgcagag     6240

cacggcgtgg aggacttttc cgtgagccag acgatgctgg aggaggtatt cttgtacttc     6300

tccaaggacc aggggaagga cgaggacacc gaagagcaga aggaggcagg agtgggagtg     6360

gaccccgcgc caggcctgca gcaccccaaa cgcgtcagcc agttcctcga tgaccctagc     6420

actgccgaga ctgtgctctg a                                               6441


<210> 8
<211> 2146
<212> PRT
<213> Homo sapiens


<400> 8
Met Ala Phe Trp Thr Gln Leu Met Leu Leu Leu Trp Lys Asn Phe Met 
1               5                   10                  15      
Tyr Arg Arg Arg Gln Pro Val Gln Leu Leu Val Glu Leu Leu Trp Pro 
            20                  25                  30          
Leu Phe Leu Phe Phe Ile Leu Val Ala Val Arg His Ser His Pro Pro 
        35                  40                  45              
Leu Glu His His Glu Cys His Phe Pro Asn Lys Pro Leu Pro Ser Ala 
    50                  55                  60                  
Gly Thr Val Pro Trp Leu Gln Gly Leu Ile Cys Asn Val Asn Asn Thr 
65                  70                  75                  80  
Cys Phe Pro Gln Leu Thr Pro Gly Glu Glu Pro Gly Arg Leu Ser Asn 
                85                  90                  95      
Phe Asn Asp Ser Leu Val Ser Arg Leu Leu Ala Asp Ala Arg Thr Val 
            100                 105                 110         
Leu Gly Gly Ala Ser Ala His Arg Thr Leu Ala Gly Leu Gly Lys Leu 
        115                 120                 125             
Ile Ala Thr Leu Arg Ala Ala Arg Ser Thr Ala Gln Pro Gln Pro Thr 
    130                 135                 140                 
Lys Gln Ser Pro Leu Glu Pro Pro Met Leu Asp Val Ala Glu Leu Leu 
145                 150                 155                 160 
Thr Ser Leu Leu Arg Thr Glu Ser Leu Gly Leu Ala Leu Gly Gln Ala 
                165                 170                 175     
Gln Glu Pro Leu His Ser Leu Leu Glu Ala Ala Glu Asp Leu Ala Gln 
            180                 185                 190         
Glu Leu Leu Ala Leu Arg Ser Leu Val Glu Leu Arg Ala Leu Leu Gln 
        195                 200                 205             
Arg Pro Arg Gly Thr Ser Gly Pro Leu Glu Leu Leu Ser Glu Ala Leu 
    210                 215                 220                 
Cys Ser Val Arg Gly Pro Ser Ser Thr Val Gly Pro Ser Leu Asn Trp 
225                 230                 235                 240 
Tyr Glu Ala Ser Asp Leu Met Glu Leu Val Gly Gln Glu Pro Glu Ser 
                245                 250                 255     
Ala Leu Pro Asp Ser Ser Leu Ser Pro Ala Cys Ser Glu Leu Ile Gly 
            260                 265                 270         
Ala Leu Asp Ser His Pro Leu Ser Arg Leu Leu Trp Arg Arg Leu Lys 
        275                 280                 285             
Pro Leu Ile Leu Gly Lys Leu Leu Phe Ala Pro Asp Thr Pro Phe Thr 
    290                 295                 300                 
Arg Lys Leu Met Ala Gln Val Asn Arg Thr Phe Glu Glu Leu Thr Leu 
305                 310                 315                 320 
Leu Arg Asp Val Arg Glu Val Trp Glu Met Leu Gly Pro Arg Ile Phe 
                325                 330                 335     
Thr Phe Met Asn Asp Ser Ser Asn Val Ala Met Leu Gln Arg Leu Leu 
            340                 345                 350         
Gln Met Gln Asp Glu Gly Arg Arg Gln Pro Arg Pro Gly Gly Arg Asp 
        355                 360                 365             
His Met Glu Ala Leu Arg Ser Phe Leu Asp Pro Gly Ser Gly Gly Tyr 
    370                 375                 380                 
Ser Trp Gln Asp Ala His Ala Asp Val Gly His Leu Val Gly Thr Leu 
385                 390                 395                 400 
Gly Arg Val Thr Glu Cys Leu Ser Leu Asp Lys Leu Glu Ala Ala Pro 
                405                 410                 415     
Ser Glu Ala Ala Leu Val Ser Arg Ala Leu Gln Leu Leu Ala Glu His 
            420                 425                 430         
Arg Phe Trp Ala Gly Val Val Phe Leu Gly Pro Glu Asp Ser Ser Asp 
        435                 440                 445             
Pro Thr Glu His Pro Thr Pro Asp Leu Gly Pro Gly His Val Arg Ile 
    450                 455                 460                 
Lys Ile Arg Met Asp Ile Asp Val Val Thr Arg Thr Asn Lys Ile Arg 
465                 470                 475                 480 
Asp Arg Phe Trp Asp Pro Gly Pro Ala Ala Asp Pro Leu Thr Asp Leu 
                485                 490                 495     
Arg Tyr Val Trp Gly Gly Phe Val Tyr Leu Gln Asp Leu Val Glu Arg 
            500                 505                 510         
Ala Ala Val Arg Val Leu Ser Gly Ala Asn Pro Arg Ala Gly Leu Tyr 
        515                 520                 525             
Leu Gln Gln Met Pro Tyr Pro Cys Tyr Val Asp Asp Val Phe Leu Arg 
    530                 535                 540                 
Val Leu Ser Arg Ser Leu Pro Leu Phe Leu Thr Leu Ala Trp Ile Tyr 
545                 550                 555                 560 
Ser Val Thr Leu Thr Val Lys Ala Val Val Arg Glu Lys Glu Thr Arg 
                565                 570                 575     
Leu Arg Asp Thr Met Arg Ala Met Gly Leu Ser Arg Ala Val Leu Trp 
            580                 585                 590         
Leu Gly Trp Phe Leu Ser Cys Leu Gly Pro Phe Leu Leu Ser Ala Ala 
        595                 600                 605             
Leu Leu Val Leu Val Leu Lys Leu Gly Asp Ile Leu Pro Tyr Ser His 
    610                 615                 620                 
Pro Gly Val Val Phe Leu Phe Leu Ala Ala Phe Ala Val Ala Thr Val 
625                 630                 635                 640 
Thr Gln Ser Phe Leu Leu Ser Ala Phe Phe Ser Arg Ala Asn Leu Ala 
                645                 650                 655     
Ala Ala Cys Gly Gly Leu Ala Tyr Phe Ser Leu Tyr Leu Pro Tyr Val 
            660                 665                 670         
Leu Cys Val Ala Trp Arg Asp Arg Leu Pro Ala Gly Gly Arg Val Ala 
        675                 680                 685             
Ala Ser Leu Leu Ser Pro Val Ala Phe Gly Phe Gly Cys Glu Ser Leu 
    690                 695                 700                 
Ala Leu Leu Glu Glu Gln Gly Glu Gly Ala Gln Trp His Asn Val Gly 
705                 710                 715                 720 
Thr Arg Pro Thr Ala Asp Val Phe Ser Leu Ala Gln Val Ser Gly Leu 
                725                 730                 735     
Leu Leu Leu Asp Ala Ala Leu Tyr Gly Leu Ala Thr Trp Tyr Leu Glu 
            740                 745                 750         
Ala Val Cys Pro Gly Gln Tyr Gly Ile Pro Glu Pro Trp Asn Phe Pro 
        755                 760                 765             
Phe Arg Arg Ser Tyr Trp Cys Gly Pro Arg Pro Pro Lys Ser Pro Ala 
    770                 775                 780                 
Pro Cys Pro Thr Pro Leu Asp Pro Lys Val Leu Val Glu Glu Ala Pro 
785                 790                 795                 800 
Pro Gly Leu Ser Pro Gly Val Ser Val Arg Ser Leu Glu Lys Arg Phe 
                805                 810                 815     
Pro Gly Ser Pro Gln Pro Ala Leu Arg Gly Leu Ser Leu Asp Phe Tyr 
            820                 825                 830         
Gln Gly His Ile Thr Ala Phe Leu Gly His Asn Gly Ala Gly Lys Thr 
        835                 840                 845             
Thr Thr Leu Ser Ile Leu Ser Gly Leu Phe Pro Pro Ser Gly Gly Ser 
    850                 855                 860                 
Ala Phe Ile Leu Gly His Asp Val Arg Ser Ser Met Ala Ala Ile Arg 
865                 870                 875                 880 
Pro His Leu Gly Val Cys Pro Gln Tyr Asn Val Leu Phe Asp Met Leu 
                885                 890                 895     
Thr Val Asp Glu His Val Trp Phe Tyr Gly Arg Leu Lys Gly Leu Ser 
            900                 905                 910         
Ala Ala Val Val Gly Pro Glu Gln Asp Arg Leu Leu Gln Asp Val Gly 
        915                 920                 925             
Leu Val Ser Lys Gln Ser Val Gln Thr Arg His Leu Ser Gly Gly Met 
    930                 935                 940                 
Gln Arg Lys Leu Ser Val Ala Ile Ala Phe Val Gly Gly Ser Gln Val 
945                 950                 955                 960 
Val Ile Leu Asp Glu Pro Thr Ala Gly Val Asp Pro Ala Ser Arg Arg 
                965                 970                 975     
Gly Ile Trp Glu Leu Leu Leu Lys Tyr Arg Glu Gly Arg Thr Leu Ile 
            980                 985                 990         
Leu Ser Thr His His Leu Asp Glu Ala Glu Leu Leu Gly Asp Arg Val 
        995                 1000                1005            
Ala Val Val Ala Gly Gly Arg Leu Cys Cys Cys Gly Ser Pro Leu Phe 
    1010                1015                1020                
Leu Arg Arg His Leu Gly Ser Gly Tyr Tyr Leu Thr Leu Val Lys Ala 
1025                1030                1035                1040
Arg Leu Pro Leu Thr Thr Asn Glu Lys Ala Asp Thr Asp Met Glu Gly 
                1045                1050                1055    
Ser Val Asp Thr Arg Gln Glu Lys Lys Asn Gly Ser Gln Gly Ser Arg 
            1060                1065                1070        
Val Gly Thr Pro Gln Leu Leu Ala Leu Val Gln His Trp Val Pro Gly 
        1075                1080                1085            
Ala Arg Leu Val Glu Glu Leu Pro His Glu Leu Val Leu Val Leu Pro 
    1090                1095                1100                
Tyr Thr Gly Ala His Asp Gly Ser Phe Ala Thr Leu Phe Arg Glu Leu 
1105                1110                1115                1120
Asp Thr Arg Leu Ala Glu Leu Arg Leu Thr Gly Tyr Gly Ile Ser Asp 
                1125                1130                1135    
Thr Ser Leu Glu Glu Ile Phe Leu Lys Val Val Glu Glu Cys Ala Ala 
            1140                1145                1150        
Asp Thr Asp Met Glu Asp Gly Ser Cys Gly Gln His Leu Cys Thr Gly 
        1155                1160                1165            
Ile Ala Gly Leu Asp Val Thr Leu Arg Leu Lys Met Pro Pro Gln Glu 
    1170                1175                1180                
Thr Ala Leu Glu Asn Gly Glu Pro Ala Gly Ser Ala Pro Glu Thr Asp 
1185                1190                1195                1200
Gln Gly Ser Gly Pro Asp Ala Val Gly Arg Val Gln Gly Trp Ala Leu 
                1205                1210                1215    
Thr Arg Gln Gln Leu Gln Ala Leu Leu Leu Lys Arg Phe Leu Leu Ala 
            1220                1225                1230        
Arg Arg Ser Arg Arg Gly Leu Phe Ala Gln Ile Val Leu Pro Ala Leu 
        1235                1240                1245            
Phe Val Gly Leu Ala Leu Val Phe Ser Leu Ile Val Pro Pro Phe Gly 
    1250                1255                1260                
His Tyr Pro Ala Leu Arg Leu Ser Pro Thr Met Tyr Gly Ala Gln Val 
1265                1270                1275                1280
Ser Phe Phe Ser Glu Asp Ala Pro Gly Asp Pro Gly Arg Ala Arg Leu 
                1285                1290                1295    
Leu Glu Ala Leu Leu Gln Glu Ala Gly Leu Glu Glu Pro Pro Val Gln 
            1300                1305                1310        
His Ser Ser His Arg Phe Ser Ala Pro Glu Val Pro Ala Glu Val Ala 
        1315                1320                1325            
Lys Val Leu Ala Ser Gly Asn Trp Thr Pro Glu Ser Pro Ser Pro Ala 
    1330                1335                1340                
Cys Gln Cys Ser Arg Pro Gly Ala Arg Arg Leu Leu Pro Asp Cys Pro 
1345                1350                1355                1360
Ala Ala Ala Gly Gly Pro Pro Pro Pro Gln Ala Val Thr Gly Ser Gly 
                1365                1370                1375    
Glu Val Val Gln Asn Leu Thr Gly Arg Asn Leu Ser Asp Phe Leu Val 
            1380                1385                1390        
Lys Thr Tyr Pro Arg Leu Val Arg Gln Gly Leu Lys Thr Lys Lys Trp 
        1395                1400                1405            
Val Asn Glu Val Arg Tyr Gly Gly Phe Ser Leu Gly Gly Arg Asp Pro 
    1410                1415                1420                
Gly Leu Pro Ser Gly Gln Glu Leu Gly Arg Ser Val Glu Glu Leu Trp 
1425                1430                1435                1440
Ala Leu Leu Ser Pro Leu Pro Gly Gly Ala Leu Asp Arg Val Leu Lys 
                1445                1450                1455    
Asn Leu Thr Ala Trp Ala His Ser Leu Asp Ala Gln Asp Ser Leu Lys 
            1460                1465                1470        
Ile Trp Phe Asn Asn Lys Gly Trp His Ser Met Val Ala Phe Val Asn 
        1475                1480                1485            
Arg Ala Ser Asn Ala Ile Leu Arg Ala His Leu Pro Pro Gly Pro Ala 
    1490                1495                1500                
Arg His Ala His Ser Ile Thr Thr Leu Asn His Pro Leu Asn Leu Thr 
1505                1510                1515                1520
Lys Glu Gln Leu Ser Glu Gly Ala Leu Met Ala Ser Ser Val Asp Val 
                1525                1530                1535    
Leu Val Ser Ile Cys Val Val Phe Ala Met Ser Phe Val Pro Ala Ser 
            1540                1545                1550        
Phe Thr Leu Val Leu Ile Glu Glu Arg Val Thr Arg Ala Lys His Leu 
        1555                1560                1565            
Gln Leu Met Gly Gly Leu Ser Pro Thr Leu Tyr Trp Leu Gly Asn Phe 
    1570                1575                1580                
Leu Trp Asp Met Cys Asn Tyr Leu Val Pro Ala Cys Ile Val Val Leu 
1585                1590                1595                1600
Ile Phe Leu Ala Phe Gln Gln Arg Ala Tyr Val Ala Pro Ala Asn Leu 
                1605                1610                1615    
Pro Ala Leu Leu Leu Leu Leu Leu Leu Tyr Gly Trp Ser Ile Thr Pro 
            1620                1625                1630        
Leu Met Tyr Pro Ala Ser Phe Phe Phe Ser Val Pro Ser Thr Ala Tyr 
        1635                1640                1645            
Val Val Leu Thr Cys Ile Asn Leu Phe Ile Gly Ile Asn Gly Ser Met 
    1650                1655                1660                
Ala Thr Phe Val Leu Glu Leu Phe Ser Asp Gln Lys Leu Gln Glu Val 
1665                1670                1675                1680
Ser Arg Ile Leu Lys Gln Val Phe Leu Ile Phe Pro His Phe Cys Leu 
                1685                1690                1695    
Gly Arg Gly Leu Ile Asp Met Val Arg Asn Gln Ala Met Ala Asp Ala 
            1700                1705                1710        
Phe Glu Arg Leu Gly Asp Arg Gln Phe Gln Ser Pro Leu Arg Trp Glu 
        1715                1720                1725            
Val Val Gly Lys Asn Leu Leu Ala Met Val Ile Gln Gly Pro Leu Phe 
    1730                1735                1740                
Leu Leu Phe Thr Leu Leu Leu Gln His Arg Ser Gln Leu Leu Pro Gln 
1745                1750                1755                1760
Pro Arg Val Arg Ser Leu Pro Leu Leu Gly Glu Glu Asp Glu Asp Val 
                1765                1770                1775    
Ala Arg Glu Arg Glu Arg Val Val Gln Gly Ala Thr Gln Gly Asp Val 
            1780                1785                1790        
Leu Val Leu Arg Asn Leu Thr Lys Val Tyr Arg Gly Gln Arg Met Pro 
        1795                1800                1805            
Ala Val Asp Arg Leu Cys Leu Gly Ile Pro Pro Gly Glu Cys Phe Gly 
    1810                1815                1820                
Leu Leu Gly Val Asn Gly Ala Gly Lys Thr Ser Thr Phe Arg Met Val 
1825                1830                1835                1840
Thr Gly Asp Thr Leu Ala Ser Arg Gly Glu Ala Val Leu Ala Gly His 
                1845                1850                1855    
Ser Val Ala Arg Glu Pro Ser Ala Ala His Leu Ser Met Gly Tyr Cys 
            1860                1865                1870        
Pro Gln Ser Asp Ala Ile Phe Glu Leu Leu Thr Gly Arg Glu His Leu 
        1875                1880                1885            
Glu Leu Leu Ala Arg Leu Arg Gly Val Pro Glu Ala Gln Val Ala Gln 
    1890                1895                1900                
Thr Ala Gly Ser Gly Leu Ala Arg Leu Gly Leu Ser Trp Tyr Ala Asp 
1905                1910                1915                1920
Arg Pro Ala Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ala Thr 
                1925                1930                1935    
Ala Leu Ala Leu Val Gly Asp Pro Ala Val Val Phe Leu Asp Glu Pro 
            1940                1945                1950        
Thr Thr Gly Met Asp Pro Ser Ala Arg Arg Phe Leu Trp Asn Ser Leu 
        1955                1960                1965            
Leu Ala Val Val Arg Glu Gly Arg Ser Val Met Leu Thr Ser His Ser 
    1970                1975                1980                
Met Glu Glu Cys Glu Ala Leu Cys Ser Arg Leu Ala Ile Met Val Asn 
1985                1990                1995                2000
Gly Arg Phe Arg Cys Leu Gly Ser Pro Gln His Leu Lys Gly Arg Phe 
                2005                2010                2015    
Ala Ala Gly His Thr Leu Thr Leu Arg Val Pro Ala Ala Arg Ser Gln 
            2020                2025                2030        
Pro Ala Ala Ala Phe Val Ala Ala Glu Phe Pro Gly Ala Glu Leu Arg 
        2035                2040                2045            
Glu Ala His Gly Gly Arg Leu Arg Phe Gln Leu Pro Pro Gly Gly Arg 
    2050                2055                2060                
Cys Ala Leu Ala Arg Val Phe Gly Glu Leu Ala Val His Gly Ala Glu 
2065                2070                2075                2080
His Gly Val Glu Asp Phe Ser Val Ser Gln Thr Met Leu Glu Glu Val 
                2085                2090                2095    
Phe Leu Tyr Phe Ser Lys Asp Gln Gly Lys Asp Glu Asp Thr Glu Glu 
            2100                2105                2110        
Gln Lys Glu Ala Gly Val Gly Val Asp Pro Ala Pro Gly Leu Gln His 
        2115                2120                2125            
Pro Lys Arg Val Ser Gln Phe Leu Asp Asp Pro Ser Thr Ala Glu Thr 
    2130                2135                2140                
Val Leu 
2145    

<210> 9
<211> 7788
<212> DNA
<213> Homo sapiens


<400> 9
atggcttccc tgtttcatca gcttcagatc ctggtctgga aaaattggct aggtgtaaaa       60

aggcagccgc tttggacact tgtcttgatc ttatggccag tcattatttt cataattttg      120

gctattactc ggaccaaatt tcctccaact gcaaaaccaa cttgttacct cgcacctcga      180

aaccttccta gtactggatt ctttccattc ctgcagaccc tactctgtga cacagactct      240

aaatgcaaag acacacccta tggcccacaa gatctgcttc gtaggaaagg aattgatgat      300

gcactattta aagacagtga gattctgaga aagtcatcca acctggataa ggacagcagt      360

ttatcattcc agagcaccca agttccagaa agaaggcatg catcactagc cacagtattt      420

cccagtccaa gttctgattt ggaaatcccc ggaacatata ctttcaatgg cagtcaagtg      480

ctcgcacgaa ttcttggctt ggaaaagctg ttaaagcaaa attcaacttc agaagatata      540

cgaagagaac tatgtgacag ctattcagga tacattgtgg atgatgcctt ctcttggacc      600

tttctaggaa gaaatgtttt taacaaattt tgcctttcta acatgaccct tttagagtct      660

tctctccaag aactaaacaa acagttctcc cagctatcca gtgaccccaa caatcagaag      720

atagtgtttc aggaaatagt cagaatgctg tctttcttct cacaagtgca agagcagaaa      780

gctgtgtggc agcttctgtc tagttttcca aatgtgtttc agaatgacac atcactaagc      840

aatctatttg atgttcttcg aaaggcaaac agtgtgctgc tggttgtgca gaaggtttat      900

ccacgttttg caactaacga aggtttcaga accctccaga agtctgttaa acatctgctg      960

tacactctgg actccccagc tcaaggtgac tccgataata taacgcatgt gtggaatgag     1020

gatgatggac agaccttatc tccaagcagt ctggctgcac agctcctaat tctggaaaac     1080

tttgaagatg ccctcttaaa tatatcagca aatagtcctt atattcctta cttggcatgt     1140

gtgagaaatg tgactgacag tttggccaga ggttcaccag aaaatctaag actcctgcag     1200

tccacaatac gatttaaaaa atcttttctt cgcaatggtt cctatgaaga ttactttcct     1260

ccagttcctg aagtcctaaa atcaaaactg tctcaacttc gaaacttgac cgaacttctt     1320

tgtgaatctg aaactttcag tttgatagag aagtcatgcc agctctctga tatgagcttt     1380

gggagcctgt gtgaagaaag tgagtttgat ctgcaactcc tcgaagcggc agagctgggc     1440

accgaaatag cagccagctt actgtaccat gacaatgtca tatctaaaaa agtgagagat     1500

ttgctgactg gagatccaag caaaattaat ttaaatatgg atcagtttct agaacaggca     1560

ctgcaaatga attacttgga aaatatcact cagttaatac cgatcataga agccatgctg     1620

catgtcaata acagtgcaga tgcttctgaa aagccaggtc agttactaga aatgtttaaa     1680

aatgttgaag agctgaaaga agatttaagg agaacaacag gaatgtccaa caggactatt     1740

gacaagttgc tggccattcc catccctgat aatagagctg agattatttc tcaggtgttc     1800

tggctgcatt cctgtgatac taatatcacc actcccaaac tagaagatgc aatgaaagaa     1860

ttctgcaacc tgtctctttc agagagatcc cggcagtctt acctcatcgg actcaccctt     1920

ctgcactact taaacattta caacttcaca tacaaggtgt ttttcccgag gaaagatcaa     1980

aagccagtag aaaagatgat ggagctcttc ataagactaa aagagattct caatcagatg     2040

gcttctggca cacatccgct gctagacaaa atgagatccc tgaagcaaat gcatctgccc     2100

agaagtgttc cattaacaca ggcaatgtac agaagcaacc gaatgaacac accacaagga     2160

tcatttagca ccatctccca agcattatgt tctcaaggaa ttaccactga atatttaact     2220

gccatgctgc cctcttccca gaggccaaaa ggcaaccaca ccaaggattt tttgacttat     2280

aaattaacta aagagcaaat tgcttcaaaa tatggaattc ccataaattc cacaccattt     2340

tgcttctccc tttataaaga catcattaac atgcccgctg gacctgtgat ttgggctttc     2400

ttgaaaccta tgttgttggg aagaattttg tatgcaccat ataacccagt cacaaaggca     2460

ataatggaaa agtccaatgt aactctgaga cagctggcgg aattaagaga aaaatctcaa     2520

gagtggatgg ataagtcgcc acttttcatg aattccttcc atctgttaaa ccaggcaatt     2580

ccaatgctcc agaatactct aaggaaccct tttgtgcaag tttttgtaaa gttctccgtg     2640

ggactcgatg ctgttgaact attgaaacag atagatgaac tcgatattct aagactgaaa     2700

ttagagaaca acattgacat catcgatcag cttaacacac tatcttccct gacagtaaat     2760

atttcctctt gtgtattata tgaccgtatt caggcagcaa aaaccataga tgaaatggag     2820

agagaggcta aaaggctcta caaaagcaac gaactctttg gaagtgttat ttttaagctt     2880

ccttctaaca gaagctggca cagaggctat gactctggaa atgtctttct tcctcctgtc     2940

ataaaatata ccatccggat gagtctcaag accgcacaga ccacaagaag cctaagaacc     3000

aagatttggg ctccagggcc acacaattct ccatcacaca accagatcta tggcagggct     3060

tttatttatt tacaggatag tattgaaaga gcaatcattg aattgcaaac tggaaggaac     3120

tcccaggaaa tagcagtcca ggttcaagca attccttatc cctgcttcat gaaagacaac     3180

ttcctaacca gtgtctctta ttctcttcca attgtgctta tggttgcctg ggttgtattt     3240

atagctgcct ttgtaaaaaa gcttgtctat gagaaagacc tccggcttca tgagtacatg     3300

aagatgatgg gtgtgaactc ctgcagccat ttctttgcct ggcttataga gagtgttgga     3360

tttttactgg ttaccatcgt gatcctcatc attatactca agtttggcaa tattcttcct     3420

aaaacaaatg ggttcatttt gttcctgtat ttttcggact acagcttctc ggttattgcc     3480

atgagctatc ttatcagtgt cttcttcaac aacaccaaca ttgcagctct gatcggaagc     3540

ctcatctaca tcattgcctt ctttccattt attgttctgg ttacagtgga gaatgagttg     3600

agctatgtat tgaaagtgtt catgagcctg ctgtccccaa cagcattcag ctatgcaagc     3660

caatacattg cacgatacga agaacagggc attggtcttc agtgggaaaa tatgtacacc     3720

tccccggttc aggatgacac cacctcattt ggctggctgt gctgtctaat cctagctgac     3780

tctttcattt atttccttat tgcttggtat gtcaggaatg tcttcccagg gacatacggt     3840

atggcagctc cctggtattt tccaattctt ccttcctatt ggaaggagcg atttgggtgt     3900

gcagaggtga agcctgagaa gagcaatggc ctcatgttta ctaacatcat gatgcagaac     3960

accaacccat ctgccagtcc tgaatacatg ttttcctcta acatcgagcc tgaacctaaa     4020

gatctcacag tcggggttgc cctgcatggg gtcacaaaga tctatggctc aaaagttgct     4080

gttgataacc tcaatctgaa cttttatgaa gggcatatta cttcattgct ggggcccaat     4140

ggagctggga aaactactac catttccatg ttaactgggc tgtttggggc ctcagcaggc     4200

accatttttg tatatggaaa agatatcaaa acagacctac acacggtacg gaagaacatg     4260

ggagtctgta tgcagcacga cgtcttgttc agttacctca ctactaagga gcaccttctc     4320

ctatatggtt ccatcaaagt tcctcactgg actaaaaagc agctccacga ggaagtaaaa     4380

aggactttaa aagatactgg actatatagc catcgtcata agagagttgg aacactgtca     4440

ggaggcatga agaggaagtt atctatatcc atagctctca ttggtggatc aagggtagta     4500

attttggatg aaccatctac tggagttgac ccatgttctc gccgaagtat atgggatgtt     4560

atatccaaga acaaaactgc cagaacaatc attctgtcaa cgcaccactt ggacgaggct     4620

gaagtgctga gtgaccgcat cgccttcctg gagcagggtg ggcttaggtg ctgtgggtcc     4680

ccattttacc tcaaggaagc ctttggcgat gggtatcacc tcacgcttac caagaagaag     4740

agtccaaatt taaatgcaaa tgcagtatgt gacaccatgg ccgtgacagc aatgatccaa     4800

tcacatctcc ccgaagccta cctcaaggag gatattgggg gagagcttgt ttatgtactt     4860

cctccattca gcaccaaagt ctcaggggcc tacctgtcac tcctacgggc actcgacaat     4920

ggcatgggtg acctcaacat cgggtgctac ggcatttcag ataccaccgt ggaggaggtc     4980

tttctgaact tgaccaaaga gtcacaaaaa aatagtgcta tgagtcttga gcacttaaca     5040

caaaagaaaa ttgggaattc caatgccaat ggcatctcaa ctcctgacga tttatctgtg     5100

agcagcagca atttcacaga cagagatgac aaaatcctga caagaggaga gaggctggat     5160

ggctttggac tgttgctgaa gaagatcatg gctatactca tcaagaggtt ccaccacacc     5220

cgcaggaact ggaaaggtct cattgctcag gttatcctcc ccatcgtctt tgttaccact     5280

gccatgggcc ttggcacact gagaaattcc agcaacagtt atccagagat tcagatctcc     5340

ccctctcttt atggtacctc cgaacagaca gccttctatg ctaattatca cccgagcacg     5400

gaagcacttg tctcagcaat gtgggacttc cctggaattg acaacatgtg tctgaacacc     5460

agtgatctac agtgtttaaa caaagacagt ctggaaaaat ggaacaccag tggagaaccc     5520

atcactaatt ttggtgtttg ctcctgctca gaaaatgtcc aggaatgtcc taaatttaac     5580

tattccccac cgcacagaag aacttactca tcccaggtaa tttataacct cactgggcaa     5640

cgagtggaaa attatcttat atcaactgca aatgagtttg tccaaaaaag atatggaggt     5700

tggagttttg ggctgccttt gacaaaagac cttcgttttg atataacagg agtccctgcc     5760

aatagaacac ttgccaaggt atggtatgat ccagaaggct atcactccct tccagcttac     5820

ctcaacagcc tgaataattt ccttctgcga gttaacatgt caaaatacga tgctgcccga     5880

catggcatca tcatgtatag ccatccttat ccaggagtgc aagaccaaga acaagccaca     5940

atcagcagtt taatcgatat tttagtggca ctgtctatct tgatgggcta ctctgtcacc     6000

accgccagct ttgtcaccta tgttgtaagg gaacatcaaa ccaaagccaa acagttgcag     6060

cacatttcag gcattggcgt gacatgctac tgggtaacaa acttcattta tgacatggtt     6120

ttctacttgg tgcctgtagc gttttcaatt ggtatcattg cgattttcaa attacctgca     6180

ttctacagtg aaaacaacct aggcgctgta tctctcctac ttctcctgtt tgggtatgca     6240

acattttcct ggatgtactt gctggctggg ctcttccatg aaacaggaat ggccttcatc     6300

acttacgtct gtgtcaactt gttttttggc attaattcca ttgtttccct gtcagtggta     6360

tactttcttt ccaaggaaaa gcctaatgat ccgactttag aacttatttc tgaaaccctc     6420

aagcgcattt tcctgatttt cccacaattc tgttttggct acggtttgat tgaactttct     6480

caacaacagt cggtcctaga cttcttaaaa gcatatggag tggaataccc aaatgaaacc     6540

tttgagatga ataaactagg tgcaatgttt gtggctttgg tttctcaggg caccatgttt     6600

ttttccttgc gactcttaat caacgaatcc ctgataaaga aactcaggct tttcttcaga     6660

aaatttaatt cttcacatgt aagggagaca atagatgagg atgaagatgt gcgggctgag     6720

agattaagag ttgagagtgg tgcagctgaa tttgacttgg tccaacttta ttgtctcaca     6780

aagacctacc aacttatcca caaaaagatt atagctgtaa acaacatcag cattgggata     6840

cctgctggag agtgttttgg gcttcttgga gtgaatggag caggaaagac cactatattc     6900

aagatgctga caggagacat cattccttca agtggaaaca ttctgatcag aaataagacc     6960

ggatctctgg gtcacgttga ttctcacagc tcattagttg gctactgtcc tcaggaagat     7020

gccttagatg acctggtaac tgtggaagaa catttgtatt tctatgccag ggtacatgga     7080

attccagaaa aggatattaa agaaactgtt cataaactcc ttaggagact tcacctgatg     7140

cccttcaagg acagagctac ctctatgtgc agttatggca caaaaagaaa attatccact     7200

gcactggcct tgatagggaa accttccatt ctactgctgg atgagccgag ctctggcatg     7260

gatccgaagt cgaaacggca cctctggaag atcatttcag aagaagtaca gaacaaatgt     7320

tccgtcatcc tcacatctca cagcatggaa gaatgtgaag ctctctgtac caggttggcc     7380

attatggtga atggaaagtt tcaatgtatt ggatctttgc agcacataaa gagcaggttt     7440

ggacgaggat ttactgtcaa agttcacttg aagaataaca aagtgaccat ggagaccctc     7500

acaaagttca tgcagctgca ctttccaaaa acatacttaa aagatcagca cctcagcatg     7560

ctagagtatc atgtaccagt cacagcagga ggagtcgcaa acatttttga tctgctggaa     7620

accaacaaga ctgctttaaa tattacaaat ttcttagtga gtcagaccac tctggaagag     7680

gttttcatca actttgccaa agaccagaag tcctatgaaa ctgctgatac cagcagccaa     7740

ggttccacta taagtgttga ctcacaagat gaccagatgg agtcttaa                  7788


<210> 10
<211> 2595
<212> PRT
<213> Homo sapiens


<400> 10
Met Ala Ser Leu Phe His Gln Leu Gln Ile Leu Val Trp Lys Asn Trp 
1               5                   10                  15      
Leu Gly Val Lys Arg Gln Pro Leu Trp Thr Leu Val Leu Ile Leu Trp 
            20                  25                  30          
Pro Val Ile Ile Phe Ile Ile Leu Ala Ile Thr Arg Thr Lys Phe Pro 
        35                  40                  45              
Pro Thr Ala Lys Pro Thr Cys Tyr Leu Ala Pro Arg Asn Leu Pro Ser 
    50                  55                  60                  
Thr Gly Phe Phe Pro Phe Leu Gln Thr Leu Leu Cys Asp Thr Asp Ser 
65                  70                  75                  80  
Lys Cys Lys Asp Thr Pro Tyr Gly Pro Gln Asp Leu Leu Arg Arg Lys 
                85                  90                  95      
Gly Ile Asp Asp Ala Leu Phe Lys Asp Ser Glu Ile Leu Arg Lys Ser 
            100                 105                 110         
Ser Asn Leu Asp Lys Asp Ser Ser Leu Ser Phe Gln Ser Thr Gln Val 
        115                 120                 125             
Pro Glu Arg Arg His Ala Ser Leu Ala Thr Val Phe Pro Ser Pro Ser 
    130                 135                 140                 
Ser Asp Leu Glu Ile Pro Gly Thr Tyr Thr Phe Asn Gly Ser Gln Val 
145                 150                 155                 160 
Leu Ala Arg Ile Leu Gly Leu Glu Lys Leu Leu Lys Gln Asn Ser Thr 
                165                 170                 175     
Ser Glu Asp Ile Arg Arg Glu Leu Cys Asp Ser Tyr Ser Gly Tyr Ile 
            180                 185                 190         
Val Asp Asp Ala Phe Ser Trp Thr Phe Leu Gly Arg Asn Val Phe Asn 
        195                 200                 205             
Lys Phe Cys Leu Ser Asn Met Thr Leu Leu Glu Ser Ser Leu Gln Glu 
    210                 215                 220                 
Leu Asn Lys Gln Phe Ser Gln Leu Ser Ser Asp Pro Asn Asn Gln Lys 
225                 230                 235                 240 
Ile Val Phe Gln Glu Ile Val Arg Met Leu Ser Phe Phe Ser Gln Val 
                245                 250                 255     
Gln Glu Gln Lys Ala Val Trp Gln Leu Leu Ser Ser Phe Pro Asn Val 
            260                 265                 270         
Phe Gln Asn Asp Thr Ser Leu Ser Asn Leu Phe Asp Val Leu Arg Lys 
        275                 280                 285             
Ala Asn Ser Val Leu Leu Val Val Gln Lys Val Tyr Pro Arg Phe Ala 
    290                 295                 300                 
Thr Asn Glu Gly Phe Arg Thr Leu Gln Lys Ser Val Lys His Leu Leu 
305                 310                 315                 320 
Tyr Thr Leu Asp Ser Pro Ala Gln Gly Asp Ser Asp Asn Ile Thr His 
                325                 330                 335     
Val Trp Asn Glu Asp Asp Gly Gln Thr Leu Ser Pro Ser Ser Leu Ala 
            340                 345                 350         
Ala Gln Leu Leu Ile Leu Glu Asn Phe Glu Asp Ala Leu Leu Asn Ile 
        355                 360                 365             
Ser Ala Asn Ser Pro Tyr Ile Pro Tyr Leu Ala Cys Val Arg Asn Val 
    370                 375                 380                 
Thr Asp Ser Leu Ala Arg Gly Ser Pro Glu Asn Leu Arg Leu Leu Gln 
385                 390                 395                 400 
Ser Thr Ile Arg Phe Lys Lys Ser Phe Leu Arg Asn Gly Ser Tyr Glu 
                405                 410                 415     
Asp Tyr Phe Pro Pro Val Pro Glu Val Leu Lys Ser Lys Leu Ser Gln 
            420                 425                 430         
Leu Arg Asn Leu Thr Glu Leu Leu Cys Glu Ser Glu Thr Phe Ser Leu 
        435                 440                 445             
Ile Glu Lys Ser Cys Gln Leu Ser Asp Met Ser Phe Gly Ser Leu Cys 
    450                 455                 460                 
Glu Glu Ser Glu Phe Asp Leu Gln Leu Leu Glu Ala Ala Glu Leu Gly 
465                 470                 475                 480 
Thr Glu Ile Ala Ala Ser Leu Leu Tyr His Asp Asn Val Ile Ser Lys 
                485                 490                 495     
Lys Val Arg Asp Leu Leu Thr Gly Asp Pro Ser Lys Ile Asn Leu Asn 
            500                 505                 510         
Met Asp Gln Phe Leu Glu Gln Ala Leu Gln Met Asn Tyr Leu Glu Asn 
        515                 520                 525             
Ile Thr Gln Leu Ile Pro Ile Ile Glu Ala Met Leu His Val Asn Asn 
    530                 535                 540                 
Ser Ala Asp Ala Ser Glu Lys Pro Gly Gln Leu Leu Glu Met Phe Lys 
545                 550                 555                 560 
Asn Val Glu Glu Leu Lys Glu Asp Leu Arg Arg Thr Thr Gly Met Ser 
                565                 570                 575     
Asn Arg Thr Ile Asp Lys Leu Leu Ala Ile Pro Ile Pro Asp Asn Arg 
            580                 585                 590         
Ala Glu Ile Ile Ser Gln Val Phe Trp Leu His Ser Cys Asp Thr Asn 
        595                 600                 605             
Ile Thr Thr Pro Lys Leu Glu Asp Ala Met Lys Glu Phe Cys Asn Leu 
    610                 615                 620                 
Ser Leu Ser Glu Arg Ser Arg Gln Ser Tyr Leu Ile Gly Leu Thr Leu 
625                 630                 635                 640 
Leu His Tyr Leu Asn Ile Tyr Asn Phe Thr Tyr Lys Val Phe Phe Pro 
                645                 650                 655     
Arg Lys Asp Gln Lys Pro Val Glu Lys Met Met Glu Leu Phe Ile Arg 
            660                 665                 670         
Leu Lys Glu Ile Leu Asn Gln Met Ala Ser Gly Thr His Pro Leu Leu 
        675                 680                 685             
Asp Lys Met Arg Ser Leu Lys Gln Met His Leu Pro Arg Ser Val Pro 
    690                 695                 700                 
Leu Thr Gln Ala Met Tyr Arg Ser Asn Arg Met Asn Thr Pro Gln Gly 
705                 710                 715                 720 
Ser Phe Ser Thr Ile Ser Gln Ala Leu Cys Ser Gln Gly Ile Thr Thr 
                725                 730                 735     
Glu Tyr Leu Thr Ala Met Leu Pro Ser Ser Gln Arg Pro Lys Gly Asn 
            740                 745                 750         
His Thr Lys Asp Phe Leu Thr Tyr Lys Leu Thr Lys Glu Gln Ile Ala 
        755                 760                 765             
Ser Lys Tyr Gly Ile Pro Ile Asn Ser Thr Pro Phe Cys Phe Ser Leu 
    770                 775                 780                 
Tyr Lys Asp Ile Ile Asn Met Pro Ala Gly Pro Val Ile Trp Ala Phe 
785                 790                 795                 800 
Leu Lys Pro Met Leu Leu Gly Arg Ile Leu Tyr Ala Pro Tyr Asn Pro 
                805                 810                 815     
Val Thr Lys Ala Ile Met Glu Lys Ser Asn Val Thr Leu Arg Gln Leu 
            820                 825                 830         
Ala Glu Leu Arg Glu Lys Ser Gln Glu Trp Met Asp Lys Ser Pro Leu 
        835                 840                 845             
Phe Met Asn Ser Phe His Leu Leu Asn Gln Ala Ile Pro Met Leu Gln 
    850                 855                 860                 
Asn Thr Leu Arg Asn Pro Phe Val Gln Val Phe Val Lys Phe Ser Val 
865                 870                 875                 880 
Gly Leu Asp Ala Val Glu Leu Leu Lys Gln Ile Asp Glu Leu Asp Ile 
                885                 890                 895     
Leu Arg Leu Lys Leu Glu Asn Asn Ile Asp Ile Ile Asp Gln Leu Asn 
            900                 905                 910         
Thr Leu Ser Ser Leu Thr Val Asn Ile Ser Ser Cys Val Leu Tyr Asp 
        915                 920                 925             
Arg Ile Gln Ala Ala Lys Thr Ile Asp Glu Met Glu Arg Glu Ala Lys 
    930                 935                 940                 
Arg Leu Tyr Lys Ser Asn Glu Leu Phe Gly Ser Val Ile Phe Lys Leu 
945                 950                 955                 960 
Pro Ser Asn Arg Ser Trp His Arg Gly Tyr Asp Ser Gly Asn Val Phe 
                965                 970                 975     
Leu Pro Pro Val Ile Lys Tyr Thr Ile Arg Met Ser Leu Lys Thr Ala 
            980                 985                 990         
Gln Thr Thr Arg Ser Leu Arg Thr Lys Ile Trp Ala Pro Gly Pro His 
        995                 1000                1005            
Asn Ser Pro Ser His Asn Gln Ile Tyr Gly Arg Ala Phe Ile Tyr Leu 
    1010                1015                1020                
Gln Asp Ser Ile Glu Arg Ala Ile Ile Glu Leu Gln Thr Gly Arg Asn 
1025                1030                1035                1040
Ser Gln Glu Ile Ala Val Gln Val Gln Ala Ile Pro Tyr Pro Cys Phe 
                1045                1050                1055    
Met Lys Asp Asn Phe Leu Thr Ser Val Ser Tyr Ser Leu Pro Ile Val 
            1060                1065                1070        
Leu Met Val Ala Trp Val Val Phe Ile Ala Ala Phe Val Lys Lys Leu 
        1075                1080                1085            
Val Tyr Glu Lys Asp Leu Arg Leu His Glu Tyr Met Lys Met Met Gly 
    1090                1095                1100                
Val Asn Ser Cys Ser His Phe Phe Ala Trp Leu Ile Glu Ser Val Gly 
1105                1110                1115                1120
Phe Leu Leu Val Thr Ile Val Ile Leu Ile Ile Ile Leu Lys Phe Gly 
                1125                1130                1135    
Asn Ile Leu Pro Lys Thr Asn Gly Phe Ile Leu Phe Leu Tyr Phe Ser 
            1140                1145                1150        
Asp Tyr Ser Phe Ser Val Ile Ala Met Ser Tyr Leu Ile Ser Val Phe 
        1155                1160                1165            
Phe Asn Asn Thr Asn Ile Ala Ala Leu Ile Gly Ser Leu Ile Tyr Ile 
    1170                1175                1180                
Ile Ala Phe Phe Pro Phe Ile Val Leu Val Thr Val Glu Asn Glu Leu 
1185                1190                1195                1200
Ser Tyr Val Leu Lys Val Phe Met Ser Leu Leu Ser Pro Thr Ala Phe 
                1205                1210                1215    
Ser Tyr Ala Ser Gln Tyr Ile Ala Arg Tyr Glu Glu Gln Gly Ile Gly 
            1220                1225                1230        
Leu Gln Trp Glu Asn Met Tyr Thr Ser Pro Val Gln Asp Asp Thr Thr 
        1235                1240                1245            
Ser Phe Gly Trp Leu Cys Cys Leu Ile Leu Ala Asp Ser Phe Ile Tyr 
    1250                1255                1260                
Phe Leu Ile Ala Trp Tyr Val Arg Asn Val Phe Pro Gly Thr Tyr Gly 
1265                1270                1275                1280
Met Ala Ala Pro Trp Tyr Phe Pro Ile Leu Pro Ser Tyr Trp Lys Glu 
                1285                1290                1295    
Arg Phe Gly Cys Ala Glu Val Lys Pro Glu Lys Ser Asn Gly Leu Met 
            1300                1305                1310        
Phe Thr Asn Ile Met Met Gln Asn Thr Asn Pro Ser Ala Ser Pro Glu 
        1315                1320                1325            
Tyr Met Phe Ser Ser Asn Ile Glu Pro Glu Pro Lys Asp Leu Thr Val 
    1330                1335                1340                
Gly Val Ala Leu His Gly Val Thr Lys Ile Tyr Gly Ser Lys Val Ala 
1345                1350                1355                1360
Val Asp Asn Leu Asn Leu Asn Phe Tyr Glu Gly His Ile Thr Ser Leu 
                1365                1370                1375    
Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser Met Leu Thr 
            1380                1385                1390        
Gly Leu Phe Gly Ala Ser Ala Gly Thr Ile Phe Val Tyr Gly Lys Asp 
        1395                1400                1405            
Ile Lys Thr Asp Leu His Thr Val Arg Lys Asn Met Gly Val Cys Met 
    1410                1415                1420                
Gln His Asp Val Leu Phe Ser Tyr Leu Thr Thr Lys Glu His Leu Leu 
1425                1430                1435                1440
Leu Tyr Gly Ser Ile Lys Val Pro His Trp Thr Lys Lys Gln Leu His 
                1445                1450                1455    
Glu Glu Val Lys Arg Thr Leu Lys Asp Thr Gly Leu Tyr Ser His Arg 
            1460                1465                1470        
His Lys Arg Val Gly Thr Leu Ser Gly Gly Met Lys Arg Lys Leu Ser 
        1475                1480                1485            
Ile Ser Ile Ala Leu Ile Gly Gly Ser Arg Val Val Ile Leu Asp Glu 
    1490                1495                1500                
Pro Ser Thr Gly Val Asp Pro Cys Ser Arg Arg Ser Ile Trp Asp Val 
1505                1510                1515                1520
Ile Ser Lys Asn Lys Thr Ala Arg Thr Ile Ile Leu Ser Thr His His 
                1525                1530                1535    
Leu Asp Glu Ala Glu Val Leu Ser Asp Arg Ile Ala Phe Leu Glu Gln 
            1540                1545                1550        
Gly Gly Leu Arg Cys Cys Gly Ser Pro Phe Tyr Leu Lys Glu Ala Phe 
        1555                1560                1565            
Gly Asp Gly Tyr His Leu Thr Leu Thr Lys Lys Lys Ser Pro Asn Leu 
    1570                1575                1580                
Asn Ala Asn Ala Val Cys Asp Thr Met Ala Val Thr Ala Met Ile Gln 
1585                1590                1595                1600
Ser His Leu Pro Glu Ala Tyr Leu Lys Glu Asp Ile Gly Gly Glu Leu 
                1605                1610                1615    
Val Tyr Val Leu Pro Pro Phe Ser Thr Lys Val Ser Gly Ala Tyr Leu 
            1620                1625                1630        
Ser Leu Leu Arg Ala Leu Asp Asn Gly Met Gly Asp Leu Asn Ile Gly 
        1635                1640                1645            
Cys Tyr Gly Ile Ser Asp Thr Thr Val Glu Glu Val Phe Leu Asn Leu 
    1650                1655                1660                
Thr Lys Glu Ser Gln Lys Asn Ser Ala Met Ser Leu Glu His Leu Thr 
1665                1670                1675                1680
Gln Lys Lys Ile Gly Asn Ser Asn Ala Asn Gly Ile Ser Thr Pro Asp 
                1685                1690                1695    
Asp Leu Ser Val Ser Ser Ser Asn Phe Thr Asp Arg Asp Asp Lys Ile 
            1700                1705                1710        
Leu Thr Arg Gly Glu Arg Leu Asp Gly Phe Gly Leu Leu Leu Lys Lys 
        1715                1720                1725            
Ile Met Ala Ile Leu Ile Lys Arg Phe His His Thr Arg Arg Asn Trp 
    1730                1735                1740                
Lys Gly Leu Ile Ala Gln Val Ile Leu Pro Ile Val Phe Val Thr Thr 
1745                1750                1755                1760
Ala Met Gly Leu Gly Thr Leu Arg Asn Ser Ser Asn Ser Tyr Pro Glu 
                1765                1770                1775    
Ile Gln Ile Ser Pro Ser Leu Tyr Gly Thr Ser Glu Gln Thr Ala Phe 
            1780                1785                1790        
Tyr Ala Asn Tyr His Pro Ser Thr Glu Ala Leu Val Ser Ala Met Trp 
        1795                1800                1805            
Asp Phe Pro Gly Ile Asp Asn Met Cys Leu Asn Thr Ser Asp Leu Gln 
    1810                1815                1820                
Cys Leu Asn Lys Asp Ser Leu Glu Lys Trp Asn Thr Ser Gly Glu Pro 
1825                1830                1835                1840
Ile Thr Asn Phe Gly Val Cys Ser Cys Ser Glu Asn Val Gln Glu Cys 
                1845                1850                1855    
Pro Lys Phe Asn Tyr Ser Pro Pro His Arg Arg Thr Tyr Ser Ser Gln 
            1860                1865                1870        
Val Ile Tyr Asn Leu Thr Gly Gln Arg Val Glu Asn Tyr Leu Ile Ser 
        1875                1880                1885            
Thr Ala Asn Glu Phe Val Gln Lys Arg Tyr Gly Gly Trp Ser Phe Gly 
    1890                1895                1900                
Leu Pro Leu Thr Lys Asp Leu Arg Phe Asp Ile Thr Gly Val Pro Ala 
1905                1910                1915                1920
Asn Arg Thr Leu Ala Lys Val Trp Tyr Asp Pro Glu Gly Tyr His Ser 
                1925                1930                1935    
Leu Pro Ala Tyr Leu Asn Ser Leu Asn Asn Phe Leu Leu Arg Val Asn 
            1940                1945                1950        
Met Ser Lys Tyr Asp Ala Ala Arg His Gly Ile Ile Met Tyr Ser His 
        1955                1960                1965            
Pro Tyr Pro Gly Val Gln Asp Gln Glu Gln Ala Thr Ile Ser Ser Leu 
    1970                1975                1980                
Ile Asp Ile Leu Val Ala Leu Ser Ile Leu Met Gly Tyr Ser Val Thr 
1985                1990                1995                2000
Thr Ala Ser Phe Val Thr Tyr Val Val Arg Glu His Gln Thr Lys Ala 
                2005                2010                2015    
Lys Gln Leu Gln His Ile Ser Gly Ile Gly Val Thr Cys Tyr Trp Val 
            2020                2025                2030        
Thr Asn Phe Ile Tyr Asp Met Val Phe Tyr Leu Val Pro Val Ala Phe 
        2035                2040                2045            
Ser Ile Gly Ile Ile Ala Ile Phe Lys Leu Pro Ala Phe Tyr Ser Glu 
    2050                2055                2060                
Asn Asn Leu Gly Ala Val Ser Leu Leu Leu Leu Leu Phe Gly Tyr Ala 
2065                2070                2075                2080
Thr Phe Ser Trp Met Tyr Leu Leu Ala Gly Leu Phe His Glu Thr Gly 
                2085                2090                2095    
Met Ala Phe Ile Thr Tyr Val Cys Val Asn Leu Phe Phe Gly Ile Asn 
            2100                2105                2110        
Ser Ile Val Ser Leu Ser Val Val Tyr Phe Leu Ser Lys Glu Lys Pro 
        2115                2120                2125            
Asn Asp Pro Thr Leu Glu Leu Ile Ser Glu Thr Leu Lys Arg Ile Phe 
    2130                2135                2140                
Leu Ile Phe Pro Gln Phe Cys Phe Gly Tyr Gly Leu Ile Glu Leu Ser 
2145                2150                2155                2160
Gln Gln Gln Ser Val Leu Asp Phe Leu Lys Ala Tyr Gly Val Glu Tyr 
                2165                2170                2175    
Pro Asn Glu Thr Phe Glu Met Asn Lys Leu Gly Ala Met Phe Val Ala 
            2180                2185                2190        
Leu Val Ser Gln Gly Thr Met Phe Phe Ser Leu Arg Leu Leu Ile Asn 
        2195                2200                2205            
Glu Ser Leu Ile Lys Lys Leu Arg Leu Phe Phe Arg Lys Phe Asn Ser 
    2210                2215                2220                
Ser His Val Arg Glu Thr Ile Asp Glu Asp Glu Asp Val Arg Ala Glu 
2225                2230                2235                2240
Arg Leu Arg Val Glu Ser Gly Ala Ala Glu Phe Asp Leu Val Gln Leu 
                2245                2250                2255    
Tyr Cys Leu Thr Lys Thr Tyr Gln Leu Ile His Lys Lys Ile Ile Ala 
            2260                2265                2270        
Val Asn Asn Ile Ser Ile Gly Ile Pro Ala Gly Glu Cys Phe Gly Leu 
        2275                2280                2285            
Leu Gly Val Asn Gly Ala Gly Lys Thr Thr Ile Phe Lys Met Leu Thr 
    2290                2295                2300                
Gly Asp Ile Ile Pro Ser Ser Gly Asn Ile Leu Ile Arg Asn Lys Thr 
2305                2310                2315                2320
Gly Ser Leu Gly His Val Asp Ser His Ser Ser Leu Val Gly Tyr Cys 
                2325                2330                2335    
Pro Gln Glu Asp Ala Leu Asp Asp Leu Val Thr Val Glu Glu His Leu 
            2340                2345                2350        
Tyr Phe Tyr Ala Arg Val His Gly Ile Pro Glu Lys Asp Ile Lys Glu 
        2355                2360                2365            
Thr Val His Lys Leu Leu Arg Arg Leu His Leu Met Pro Phe Lys Asp 
    2370                2375                2380                
Arg Ala Thr Ser Met Cys Ser Tyr Gly Thr Lys Arg Lys Leu Ser Thr 
2385                2390                2395                2400
Ala Leu Ala Leu Ile Gly Lys Pro Ser Ile Leu Leu Leu Asp Glu Pro 
                2405                2410                2415    
Ser Ser Gly Met Asp Pro Lys Ser Lys Arg His Leu Trp Lys Ile Ile 
            2420                2425                2430        
Ser Glu Glu Val Gln Asn Lys Cys Ser Val Ile Leu Thr Ser His Ser 
        2435                2440                2445            
Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Asn 
    2450                2455                2460                
Gly Lys Phe Gln Cys Ile Gly Ser Leu Gln His Ile Lys Ser Arg Phe 
2465                2470                2475                2480
Gly Arg Gly Phe Thr Val Lys Val His Leu Lys Asn Asn Lys Val Thr 
                2485                2490                2495    
Met Glu Thr Leu Thr Lys Phe Met Gln Leu His Phe Pro Lys Thr Tyr 
            2500                2505                2510        
Leu Lys Asp Gln His Leu Ser Met Leu Glu Tyr His Val Pro Val Thr 
        2515                2520                2525            
Ala Gly Gly Val Ala Asn Ile Phe Asp Leu Leu Glu Thr Asn Lys Thr 
    2530                2535                2540                
Ala Leu Asn Ile Thr Asn Phe Leu Val Ser Gln Thr Thr Leu Glu Glu 
2545                2550                2555                2560
Val Phe Ile Asn Phe Ala Lys Asp Gln Lys Ser Tyr Glu Thr Ala Asp 
                2565                2570                2575    
Thr Ser Ser Gln Gly Ser Thr Ile Ser Val Asp Ser Gln Asp Asp Gln 
            2580                2585                2590        
Met Glu Ser 
        2595

<210> 11
<211> 15177
<212> DNA
<213> Homo sapiens


<400> 11
atggggcatg ccgggtgcca gttcaaagcc ctgctgtgga agaattggct ctgcagactc       60

aggaacccgg tccttttcct tgctgaattc ttctggcctt gtatcctgtt tgtaattctg      120

acagttcttc gttttcaaga acctcccaga tacagagaca tttgttattt gcagccccga      180

gatctaccca gctgtggtgt tatccccttt gttcaaagcc ttctttgtaa cactggatca      240

aggtgtagga acttcagcta tgaagggtca atggagcatc attttcgttt gtctaggttc      300

caaactgcag ctgaccccaa gaaagtcaac aacctggcct ttttaaaaga gatacaagac      360

ctggcagagg aaattcatgg aatgatggac aaggcaaaaa acttaaaaag actttgggta      420

gaacgatcca acactccaga ttcttcttat ggttccagtt tttttacaat ggatctcaat      480

aagaccgagg aggtaatatt gaaactggaa agcctccatc agcagcctca tatctgggat      540

tttctacttt tactgccgag actacacaca agccatgatc atgtggaaga tggcatggat      600

gttgcagtga accttctcca gaccattttg aattccttaa tatccctaga agatttagat      660

tggcttccac tcaaccaaac tttttcccag gtttctgaac ttgtactgaa tgtgaccatt      720

tcgacactga catttctgca gcaacatgga gtagcagtca ccgagccagt ttaccacctg      780

tccatgcaga atatagtgtg ggatccacag aaagtccagt atgatctcaa atcccagttt      840

ggctttgatg atcttcacac ggaacagatc ctgaactctt cagctgaact gaaggagatt      900

cccacagaca cttccttgga gaagatggtg tgttcagtct tgtctagcac atcagaggat      960

gaagctgaga aatggggcca cgttggaggc tgccacccta agtggtcaga agccaaaaac     1020

tatcttgtcc atgcagtcag ctggctgcga gtctaccaac aggtgtttgt tcagtggcaa     1080

cagggtagcc tgcttcagaa gacactcaca ggcatgggcc atagtctgga ggctctcagg     1140

aatcagtttg aagaagagag caagccctgg aaggtggtgg aagctctgca cactgcactg     1200

ctcctgctga atgacagctt gtcagcagat ggcccaaaag ataatcatac atttccaaag     1260

atattacagc atctgtggaa attgcaaagc ttgctgcaaa acctgcccca gtggccggca     1320

ctgaagagat ttcttcagct tgatggagct ctcagaaatg cgatagctca gaatttacat     1380

tttgtccaag aagtcctcat ttgcctggag acatcagcta atgattttaa atggtttgaa     1440

cttaaccaat tgaaactgga aaaggatgtg ttcttttggg agctgaaaca gatgttggcg     1500

aagaatgctg tctgcccgaa tggtcgtttc tctgagaagg aggtcttttt gccgcctgga     1560

aactccagca tatggggtgg tctccaggga ctgttgtgct attgtaactc ctctgagacg     1620

agtgttttaa acaagctact tggttcagta gaggatgctg atcgtatttt gcaagaggtc     1680

attacttggc acaaaaatat gtcagtttta atacctgaag aatatttgga ctggcaggaa     1740

cttgagatgc agctgtcaga agcaagcctt tcctgtactc ggctcttcct gctgctggga     1800

gctgatccct ctcctgagaa tgatgtcttt tctagtgact gtaagcacca gcttgtctcc     1860

acagtgatat ttcatacact tgaaaaaaca caatttttcc tggaacaagc atattattgg     1920

aaagccttca aaaagtttat caggaagact tgcgaagtgg cccaatatgt aaatatgcaa     1980

gagagtttcc agaacagact attggctttt cctgaggaat ctccttgttt tgaagaaaac     2040

atggattgga aaatgatcag tgataattat tttcaatttt tgaataactt actcaagtct     2100

ccaacagctt ccatatccag ggctttaaat ttcacaaagc accttctaat gatggaaaag     2160

aagttgcaca cccttgagga tgaacaaatg aactttcttt tatcatttgt ggaatttttt     2220

gagaaattat tgttgcctaa tctttttgac tcctccattg ttcccagttt ccacagcctc     2280

ccatctctca cagaggatat tctgaatata agttctctgt ggacaaatca tttaaaaagt     2340

ttaaagagag acccatctgc cactgatgct cagaaactct tggaatttgg caacgaagtg     2400

atttggaaaa tgcagactct cggaagtcac tggataagga aggaaccaaa aaatcttttg     2460

agattcatag aattaatact ttttgaaatt aatcccaaat tactagaatt atgggcctat     2520

ggcatttcaa aaggaaaaag agctaaattg gaaaacttct ttacactttt aaatttttct     2580

gttccagaaa atgagattct gagtacaagt tttaactttt cccagttgtt ccattcagat     2640

tggcctaaat caccagctat gaacatagat tttgtacgtt taagtgaggc tataataact     2700

agtctccatg aatttggatt tttggagcag gaacagatct cagaagctct gaacacagtc     2760

tacgctatca ggaatgcatc tgatcttttc tcagcccttt ctgaaccaca aaaacaagaa     2820

gttgataaaa ttttgactca catacaccta aatgtcttcc aggacaagga ttcagcttta     2880

cttctgcaaa tttattcttc attttaccga tatatttatg aattattgaa tattcagagt     2940

agaggctctt cgttgacttt ccttacacaa atctcaaaac acattttgga tatcataaaa     3000

caatttaatt tccaaaacat cagtaaagca tttgcatttt tatttaagac agcagaggtt     3060

cttgggggaa tttctaatgt atcttactgt cagcaattgc tttcaatttt taactttttg     3120

gagcttcagg cccaatcctt catgtctaca gagggccaag aactggaagt gatccacact     3180

actttgacag gcctcaaaca gctgctcata attgatgaag attttcgtat ttctttattt     3240

caatatatga gccaattctt caacagttca gtagaagacc tattggataa taaatgcttg     3300

atttcggaca ataaacacat ttcttccgta aattattcaa caagtgagga gtcttcattt     3360

gtttttccat tggcacaaat tttttcaaac ctctcagcaa atgtcagtgt gttcaacaag     3420

tttatgtcca ttcactgtac cgtttcatgg cttcaaatgt ggactgaaat ctgggaaacc     3480

atatctcaat tatttaagtt tgacatgaat gttttcacat ctcttcatca tggtttcact     3540

cagcttttgg atgaattgga agatgatgtg aaagtctcta aaagctgcca gggtatactt     3600

cccacccata atgttgctag actcatatta aatttgttta aaaatgtaac tcaagccaat     3660

gacttccata attgggagga cttcctggat ctcagggatt ttttggtagc tttaggtaat     3720

gcattagttt cagtaaaaaa acttaacttg gagcaagtgg agaaatccct tttcaccatg     3780

gaagctgccc tgcatcagtt gaagacattt ccattcaacg aaagtacaag cagagagttt     3840

ttaaattctc tgcttgaagt tttcattgag tttagcagta cctcagaata tatagtcaga     3900

aatctagatt caataaatga ctttctttca aataatctca caaattatgg agaaaaattt     3960

gaaaatatca tcactgagct aagagaagca atagtatttc ttagaaatgt atcacatgat     4020

cgagatttgt tttcctgtgc tgatattttc caaaatgtta ctgagtgtat tttagaagat     4080

ggctttttat atgtaaatac ctcacagagg atgttacgta ttctagacac gttaaattcc     4140

acattttcct ctgagaacac aattagcagt ctgaaaggat gcattgtatg gttagatgtc     4200

ataaaccatt tgtatttgtt gtctaactcc agtttttcac aaggtcatct tcaaaatatt     4260

ttggggaatt tcagagatat agaaaacaaa atgaactcta tattaaaaat tgtaacttgg     4320

gtgttaaata taaaaaaacc tctttgttca tcaaatggct cacatataaa ttgtgtcaat     4380

atttacttga aagatgtaac tgactttcta aatattgtac ttactacagt ctttgaaaaa     4440

gagaagaaac ctaaatttga gattttatta gctcttttaa atgattccac aaagcaagta     4500

aggatgagta tcaacaactt aacaacagac tttgattttg catctcagtc caattggaga     4560

tattttactg aattaattct aagaccaata gaaatgtcag atgaaattcc taatcagttt     4620

caaaatattt ggcttcattt aataacactg gggaaggaat ttcagaagct tgtaaaaggt     4680

atttacttta acatcctgga aaataattcc tcttctaaaa ctgaaaactt gttaaacata     4740

tttgccacca gtccaaaaga aaaggatgta aacagtgtag gcaattccat ttatcactta     4800

gctagttacc ttgccttcag cttatctcat gacctccaaa attcaccaaa aataataatt     4860

tcacctgaaa taatgaaagc tacaggtctt ggtattcaac tgataaggga tgtgttcaac     4920

tccttaatgc ctgtagttca tcacactagt ccacaaaatg caggttatat gcaagctttg     4980

aagaaggtaa cttctgtcat gcgtaccctt aagaaggcag acatagacct tttagtggat     5040

cagcttgaac aagttagtgt aaacctaatg gatttcttta agaatatcag tagtgtggga     5100

actggcaatt tagtggtcaa tttgcttgtt ggcttgatgg aaaaatttgc agacagctca     5160

cattcttgga atgttaatca tctgctgcag ctctcacgcc tgtttcctaa agatgttgtg     5220

gatgctgtga tagatgtgta ctatgtgctt cctcatgctg taaggctcct gcagggagta     5280

cctggtaaaa acatcactga aggcctcaag gatgtctaca gcttcacact ccttcatggc     5340

ataaccattt caaatatcac caaggaagac ttcgcaattg tgataaaaat tcttttggat     5400

acaattgaat tagtatcaga taagccagat attatttcag aggctttagc ttgttttcct     5460

gtggtttggt gctggaatca cacaaattct ggatttcggc agaattcaaa gatagacccc     5520

tgcaatgtcc atgggctcat gtcttcttcc ttttatggca aagtggccag tatacttgat     5580

catttccacc tgtctcccca aggtgaagat tcaccatgtt caaatgaaag ctcccgaatg     5640

gaaataacta ggaaagtggt ctgcataatt catgaattag tggactggaa ttctattctt     5700

ctggagctct ctgaagtctt ccatgttaac atttctcttg tgaaaactgt gcagaaattt     5760

tggcataaga tattaccgtt tgtcccacct tcaataaatc aaactaggga tagcatctct     5820

gaactctgtc ctagtggttc cataaagcaa gttgctttgc aaatcataga aaaacttaaa     5880

aatgtcaact ttacaaaagt tacatcaggt gaaaatattc ttgacaaact aagtagttta     5940

aacaagatcc ttaacattaa tgaagacaca gagacatctg ttcaaaatat tatttcctca     6000

aatttggaaa ggacagtaca attgatttct gaagactgga gcctagaaaa aagtacgcat     6060

aatctactct ctttattcat gatgctccag aatgcaaatg tcacaggtag cagtttagaa     6120

gcattatcaa gttttattga aaaaagtgaa acaccttaca actttgaaga actatggccc     6180

aagtttcaac aaatcatgaa agacctaacc caagatttta gaatcagaca cctgctttct     6240

gaaatgaaca aaggaatcaa aagtataaat tcaatggctc ttcaaaagat aactttgcag     6300

tttgcccatt tcctggaaat cctggattca ccgtcattga agacattaga aattattgaa     6360

gattttctat tggtcacaaa aaactggctt caggaatatg caaatgagga ttactccaga     6420

atgatagaaa cattattcat tcctgtgacc aatgagagtt caactgaaga tatagctttg     6480

ttagccaaag ctattgctac tttttggggc tctttaaaaa atatatctag agcaggcaat     6540

tttgatgttg cctttcttac ccatctgcta aatcaagaac agctgactaa tttctcagtt     6600

gttcagctgc tttttgaaaa catcctaatt aatttgatca ataacttagc tgggaattct     6660

caggaagcag cttggaactt aaatgatact gaccttcaaa taatgaattt cattaacctt     6720

atcttgaacc atatgcagtc agaaactagt aggaaaacag ttctctctct gagaagcata     6780

gtagatttca cagaacagtt tttgaaaaca ttcttctccc tttttctaaa ggaagattct     6840

gagaacaaaa tatctcttct gctgaaatat ttccacaaag atgttattgc agagatgagt     6900

tttgtcccaa aagataaaat tctagaaatt ctgaaactgg atcaatttct taccctgatg     6960

atacaagaca gattgatgaa cattttttca agtttaaagg agactatata tcacctaatg     7020

aaaagttcat ttatattaga caatggagaa ttttattttg atactcatca aggactgaag     7080

ttcatgcaag atttatttaa tgcccttctc agggaaactt caatgaaaaa taagactgaa     7140

aataatatag actttttcac agtggtgagt cagttgtttt tccatgtgaa taagtctgag     7200

gacctcttca aactcaatca agatcttggg tcagctcttc accttgtaag agaatgttca     7260

acagagatgg caagacttct ggatacaatt ttacactctc ctaataagga cttctatgct     7320

ttgtatccta ccctccaaga agttatactt gctaatctaa cggatttgct tttctttata     7380

aataattcat tccctctaag aaacagagca acattagaaa ttactaagag attagttggt     7440

gctatttcaa gagcaagtga agaaagtcac gtcctgaaac ccctcttaga aatgtctggg     7500

actctggtca tgctgttgaa tgacagtgct gacctgagag atcttgccac atcaatggac     7560

tccattgtga aacttcttaa gctggtcaag aaagtttcgg ggaagatgtc cacagttttt     7620

aaaactcatt ttatctccaa taccaaggac agtgtgaaat tctttgacac tctgtattcc     7680

atcatgcaac aaagtgttca aaatcttgtg aaagaaatag ctactttaaa aaaaatagat     7740

catttcacat ttgaaaagat aaatgatttg ttggtgccat ttcttgactt ggcctttgaa     7800

atgattgggg tagaacctta tatatcatca aactctgata ttttcagtat gtcacctagc     7860

atactctcat atatgaacca atctaaggac ttttctgata ttttggaaga aattgctgaa     7920

tttttaacat ctgtgaaaat gaacttggaa gatatgagga gtcttgcggt agcatttaac     7980

aatgagactc aaacattttc tatggattct gtcaacttac gggaagaaat tctgggttgc     8040

ttagttccta taaataacat caccaaccaa atggacttct tataccctaa tccaatttcc     8100

actcatagtg gccctcaaga tataaaatgg gaaataattc atgaagtgat cccttttttg     8160

gataaaatat tatcacaaaa cagcacagaa ataggatctt tcttgaaaat ggtgatctgt     8220

ctcaccttag aagctctttg gaaaaactta aagaaagata attggaatgt ttctaatgtg     8280

ttgatgacat ttactcagca tccaaataac cttttgaaaa ccatagaaac agttttagag     8340

gcctccagtg gaattaaaag tgactatgaa ggtgatttga ataaaagttt atattttgac     8400

acacctttga gtcagaatat aactcatcat caacttgaaa aagcaatcca taatgtttta     8460

agtagaatag ctctctggag gaaaggactt ctgtttaaca actctgaatg gataacttcc     8520

acaagaactt tgtttcagcc actttttgag attttcatta aagcaaccac cggaaagaat     8580

gtcacatcag aaaaagaaga gagaaccaag aaagagatga ttgactttcc ttatagtttc     8640

aaaccatttt tctgtttgga gaaatacctg ggaggattat ttgtattgac taaatactgg     8700

caacaaatcc cactaacaga tcaaagtgtt gttgagattt gtgaagtttt ccagcagact     8760

gtgaagccct cagaagccat ggagatgctg cagaaagtga agatgatggt cgtacgtgtg     8820

ctcaccatcg ttgcagaaaa cccttcctgg accaaggaca ttttgtgtgc tactctgagt     8880

tgcaagcaaa atgggataag gcatctcatt ttatctgcta tacaaggggt cactttggcg     8940

caggaccact tccaggaaat tgaaaagata tggtcctcgc cgaatcagct aaattgtgaa     9000

agtcttagca agaatctttc tagcaccttg gagagcttca agagcagctt ggaaaatgcc     9060

actggccagg actgcacaag ccagccgagg ctggagacgg tgcagcagca cttgtacatg     9120

ttggccaaaa gcctcgagga aacttggtca tcagggaatc ccatcatgac ttttctcagc     9180

aatttcacag taactgagga tgtaaaaata aaagatttga tgaagaatat caccaagttg     9240

actgaggagc ttcgctcttc catccaaatc tcgaatgaga ctatccatag cattctagaa     9300

gcaaatattt cccactccaa ggttctcttc agtgccctca ccgtagctct gtctggaaag     9360

tgtgatcagg aaatccttca tctcctgctg acatttccca aaggggaaaa atcttggatc     9420

gcagcggagg aactctgtag cctgccaggg tcaaaagtgt attctctgat tgtgttgctg     9480

agtcgaaact tggatgtgcg agctttcatt tacaagactc tgatgccttc tgaagcaaat     9540

ggcttgctca actccttgct ggatatagtt tccagcctca gcgccttgct tgccaaagcc     9600

cagcacgtct ttgagtatct tcctgagttt cttcacacat ttaaaatcac tgccttgcta     9660

gaaaccctgg actttcaaca ggtttcacaa aatgtccagg ccagaagttc agcttttggt     9720

tctttccagt ttgtgatgaa gatggtttgc aaggaccaag catcattcct tagcgattct     9780

aatatgttta ttaatttgcc cagagttaag gaactcttgg aagatgacaa agaaaaattc     9840

aacattcctg aagattcaac accgttttgc ttgaagcttt atcaggaaat tctacaattg     9900

ccaaatggtg ctttggtgtg gaccttccta aaacccatat tgcatggaaa aatactatac     9960

acaccaaaca ctccagaaat taacaaggtc attcaaaagg ctaattacac cttttatatt    10020

gtggacaaac taaaaacttt atcagaaaca ctgctggaaa tgtccagcct tttccagaga    10080

agtggaagtg gccagatgtt caaccagctg caggaggccc tgagaaacaa atttgtaaga    10140

aactttgtag aaaaccagtt gcacattgat gtagacaaac ttactgaaaa actccagaca    10200

tacggagggc tgctggatga gatgtttaac catgcaggcg ctggacgctt ccgtttcttg    10260

ggcagcatct tggtcaatct ctcttcctgc gtggcactga accgtttcca ggctctgcag    10320

tctgtcgaca tcctggagac taaagcacat gaactcttgc agcagaacag cttcttggcc    10380

agtatcattt tcagcaattc cttattcgac aagaacttca gatcagagtc tgtcaaactg    10440

ccaccccatg tctcatacac aatccggacc aatgtgttat acagcgtgcg aacagatgtg    10500

gtaaaaaacc cttcttggaa gttccaccct cagaatctac cagctgatgg gttcaaatat    10560

aactacgtct ttgccccact gcaagacatg atcgaaagag ccatcatttt ggtgcagact    10620

gggcaggaag ccctggaacc agcagcacag actcaggcgg ccccttaccc ctgccatacc    10680

agcgacctat tcctgaacaa cgttggtttc ttttttccac tgataatgat gctgacgtgg    10740

atggtgtctg tggccagcat ggtcagaaag ttggtgtatg agcaggagat acagatagaa    10800

gagtatatgc ggatgatggg agtgcatcca gtgatccatt tcctggcctg gttcctggag    10860

aacatggctg tgttgaccat aagcagtgct actctggcca tcgttctgaa aacaagtggc    10920

atctttgcac acagcaatac ctttattgtt ttcctctttc tcttggattt tgggatgtca    10980

gtcgtcatgc tgagctacct cttgagtgca tttttcagcc aagctaatac agcggccctt    11040

tgtaccagcc tggtgtacat gatcagcttt ctgccctaca tagttctatt ggttctacat    11100

aaccaattaa gttttgttaa tcagacattt ctgtgccttc tttcgacaac cgcctttgga    11160

caaggggtat tttttattac attcctggaa ggacaagaga cagggattca atggaataat    11220

atgtaccagg ctctggaaca agggggcatg acatttggct gggtttgctg gatgattctt    11280

tttgattcaa gcctttattt tttgtgtgga tggtacttga gcaacttgat tcctggaaca    11340

tttggtttac ggaaaccatg gtatttcccc tttactgcct catattggaa gagtgtgggt    11400

ttcttggtgg agaaaaggca atactttcta agttctagtc tgttcttctt caatgagaac    11460

tttgacaata aagggtcatc actgcaaaac agggaaggag agcttgaagg aagtgccccg    11520

ggagtcaccc tggtgtctgt gaccaaggaa tatgagggcc acaaggctgt ggtccaagac    11580

ctcagcctga ccttctacag agaccaaatc accgccctgc tggggacaaa cggtgccggg    11640

aaaaccacta tcatatccat gttgacgggg ctccaccctc ccacttctgg aaccatcatc    11700

atcaatggca agaacctaca gacagacctg tcgagggtca gaatggagct tggtgtgtgt    11760

ccgcagcagg acatcctgtt ggacaacctc accgtccggg aacatttgct gctctttgct    11820

tccataaagg cgcctcagtg gaccaagaag gagctgcatc agcaagtcaa tcaaactctt    11880

caggatgtgg acttaactca gcatcagcac aaacagaccc gagctctgtc tggaggcctg    11940

aagaggaagc tctcccttgg cattgctttc atgggcatgt cgaggaccgt ggttctggat    12000

gagcccacca gtggggtgga cccttgctcc cggcatagcc tgtgggacat tctgctcaag    12060

taccgagaag gtcgtacgat catcttcaca acccaccacc tggatgaagc tgaagcgctg    12120

agtgaccgcg tggccgtcct ccagcatggg aggctcaggt gctgcggtcc tcccttctgc    12180

ctgaaggagg catatggcca ggggctccgc ctgacactca cgaggcagcc ttctgttctg    12240

gaggcccatg atctgaaaga catggcttgt gttacatccc tgataaagat ctatattcca    12300

caagcatttc tcaaagacag cagtggaagt gagctgacct acaccattcc aaaggacaca    12360

gacaaggcct gcttgaaagg gctcttccag gccctggatg agaacctgca tcagctgcac    12420

ctgacgggct atgggatctc agacaccacc ttagaagagg tgtttttgat gcttttgcaa    12480

gattccaaca agaaatctca cattgccctg gggactgagt cagagctgca gaaccacagg    12540

cctacaggac atctgtctgg ctactgtggc tccctagcac ggcccgcaac tgtgcagggc    12600

gtccagctgc tccgcgcaca agtggccgcg atcctggccc ggaggctccg ccgcacgctg    12660

cgcgccggga agagcaccct cgccgacctg ctgctgccag tcctcttcgt ggccttggcc    12720

atgggcttgt tcatggtgag acccctggcc accgagtacc ctcccctcag actcacacct    12780

ggacattacc agcgggccga gacctacttt ttcagcagtg ggggcgacaa cttggacctc    12840

acccgtgtgc ttctgcggaa gtttagagat caagatttgc cctgtgcaga tttaaaccca    12900

cgccagaaga attcttcatg ctggcgcaca gatccctttt ctcacccaga attccaggat    12960

tcatgtggct gcctgaagtg tccaaataga agtgctagtg ctccctacct gaccaaccac    13020

ctgggccaca cactgttgaa tctctcaggc ttcaatatgg aggagtactt gctggcacca    13080

tctgaaaaac caaggcttgg aggttggtct tttggattaa aaatccccag tgaagctgga    13140

ggtgcaaatg gaaacatatc aaaaccccca actctggcaa aggtgtggta taatcagaag    13200

ggttttcatt ccctaccttc ctacttaaat catctaaaca accttatttt gtggcagcac    13260

ctacccccta ctgtggactg gagacaatac ggaataacac tctacagcca cccatatgga    13320

ggggccttgc tgaacgagga caagatcctg gagagcatcc gtcagtgtgg agtggccctc    13380

tgcatcgtgc tgggattctc catcctgtct gcatccatcg gcagctctgt ggtgagggac    13440

agggtgattg gagccaaaag gttgcagcac ataagtggcc ttggctacag gatgtactgg    13500

ttcacaaact tcctatatga catgctcttt tacttggttt ccgtctgcct gtgtgttgcc    13560

gttattgtcg ccttccagtt aacagctttt actttccgca agaacttggc agccacggcc    13620

ctcctgctgt cacttttcgg atatgcaact cttccatgga tgtacctgat gtccagaatc    13680

ttttccagtt cggacgtggc tttcatttcc tatgtctcac taaacttcat ctttggcctt    13740

tgtaccatgc tcataaccat tatgccccgg ttgctagcca tcatctccaa agctaagaat    13800

ttacagaata tctatgatgt cctcaagtgg gtctttacta tttttcctca attctgtctt    13860

ggtcaaggac tggtagaact ctgctataat cagatcaaat atgacctgac ccacaacttc    13920

ggcattgatt cctatgtgag tccctttgag atgaactttc tgggctggat cttcgtgcaa    13980

ctggcctcgc agggcacagt acttctcctc ttgagggttc tgctacactg ggaccttctg    14040

cgatggccaa ggggtcattc tactctccaa ggcacagtca aatcttctaa ggatacagat    14100

gttgaaaaag aggaaaagag agtgtttgaa ggaaggacca atggagacat tcttgtgtta    14160

tacaacctta gtaaacatta tcgacgcttt ttccagaata ttattgctgt gcaagatatt    14220

agtttgggca taccaaaagg agagtgcttt ggacttctag gggtgaatgg agctgggaag    14280

agcacgactt tcaaaatgct gaatggtgaa gtttctctaa cttcaggaca tgctatcatc    14340

aggactccca tgggagacgc cgtggacctg tcttctgctg gcacggcagg cgtgctcatt    14400

ggctactgtc cccagcagga tgccctggac gagcttctga ctggttggga acatctctat    14460

tattactgta gcttacgcgg gattccaagg cagtgcatcc ctgaggttgc tggagacctc    14520

atcaggcgct tacacctcga agcccacgcg gacaaacctg tggccaccta cagtggggga    14580

accaagcgga aactctctac agccctggcc ctggtgggga aacctgacat tcttttattg    14640

gatgagccca gctctgggat ggatccctgc tctaagcggt acctgtggca aacaataatg    14700

aaggaggttc gggaaggctg tgctgcggtg ctgacctccc acagcatgga ggagtgtgag    14760

gctctttgca caagactggc cataatggtt aacggcagct tcaaatgtct tggttctcct    14820

cagcacatca aaaataggtt tggtgatggt tatacagtca aagtttggct ctgtaaggaa    14880

gcaaatcaac attgcactgt ttctgaccac ttgaagcttt attttccagg aattcagttc    14940

aagggacagc acctgaattt attagaatat catgtgccaa aaagatgggg atgcctagct    15000

gacttgttca aagttataga gaacaataaa accttcttga atattaagca ttattccatt    15060

aaccaaacca ctttggagca ggtatttatt aattttgctt ctgagcagca gcaaactcta    15120

caatctactc ttgatccatc cactgacagt caccacacac atcacttgcc catctga       15177


<210> 12
<211> 5058
<212> PRT
<213> Homo sapiens


<400> 12
Met Gly His Ala Gly Cys Gln Phe Lys Ala Leu Leu Trp Lys Asn Trp 
1               5                   10                  15      
Leu Cys Arg Leu Arg Asn Pro Val Leu Phe Leu Ala Glu Phe Phe Trp 
            20                  25                  30          
Pro Cys Ile Leu Phe Val Ile Leu Thr Val Leu Arg Phe Gln Glu Pro 
        35                  40                  45              
Pro Arg Tyr Arg Asp Ile Cys Tyr Leu Gln Pro Arg Asp Leu Pro Ser 
    50                  55                  60                  
Cys Gly Val Ile Pro Phe Val Gln Ser Leu Leu Cys Asn Thr Gly Ser 
65                  70                  75                  80  
Arg Cys Arg Asn Phe Ser Tyr Glu Gly Ser Met Glu His His Phe Arg 
                85                  90                  95      
Leu Ser Arg Phe Gln Thr Ala Ala Asp Pro Lys Lys Val Asn Asn Leu 
            100                 105                 110         
Ala Phe Leu Lys Glu Ile Gln Asp Leu Ala Glu Glu Ile His Gly Met 
        115                 120                 125             
Met Asp Lys Ala Lys Asn Leu Lys Arg Leu Trp Val Glu Arg Ser Asn 
    130                 135                 140                 
Thr Pro Asp Ser Ser Tyr Gly Ser Ser Phe Phe Thr Met Asp Leu Asn 
145                 150                 155                 160 
Lys Thr Glu Glu Val Ile Leu Lys Leu Glu Ser Leu His Gln Gln Pro 
                165                 170                 175     
His Ile Trp Asp Phe Leu Leu Leu Leu Pro Arg Leu His Thr Ser His 
            180                 185                 190         
Asp His Val Glu Asp Gly Met Asp Val Ala Val Asn Leu Leu Gln Thr 
        195                 200                 205             
Ile Leu Asn Ser Leu Ile Ser Leu Glu Asp Leu Asp Trp Leu Pro Leu 
    210                 215                 220                 
Asn Gln Thr Phe Ser Gln Val Ser Glu Leu Val Leu Asn Val Thr Ile 
225                 230                 235                 240 
Ser Thr Leu Thr Phe Leu Gln Gln His Gly Val Ala Val Thr Glu Pro 
                245                 250                 255     
Val Tyr His Leu Ser Met Gln Asn Ile Val Trp Asp Pro Gln Lys Val 
            260                 265                 270         
Gln Tyr Asp Leu Lys Ser Gln Phe Gly Phe Asp Asp Leu His Thr Glu 
        275                 280                 285             
Gln Ile Leu Asn Ser Ser Ala Glu Leu Lys Glu Ile Pro Thr Asp Thr 
    290                 295                 300                 
Ser Leu Glu Lys Met Val Cys Ser Val Leu Ser Ser Thr Ser Glu Asp 
305                 310                 315                 320 
Glu Ala Glu Lys Trp Gly His Val Gly Gly Cys His Pro Lys Trp Ser 
                325                 330                 335     
Glu Ala Lys Asn Tyr Leu Val His Ala Val Ser Trp Leu Arg Val Tyr 
            340                 345                 350         
Gln Gln Val Phe Val Gln Trp Gln Gln Gly Ser Leu Leu Gln Lys Thr 
        355                 360                 365             
Leu Thr Gly Met Gly His Ser Leu Glu Ala Leu Arg Asn Gln Phe Glu 
    370                 375                 380                 
Glu Glu Ser Lys Pro Trp Lys Val Val Glu Ala Leu His Thr Ala Leu 
385                 390                 395                 400 
Leu Leu Leu Asn Asp Ser Leu Ser Ala Asp Gly Pro Lys Asp Asn His 
                405                 410                 415     
Thr Phe Pro Lys Ile Leu Gln His Leu Trp Lys Leu Gln Ser Leu Leu 
            420                 425                 430         
Gln Asn Leu Pro Gln Trp Pro Ala Leu Lys Arg Phe Leu Gln Leu Asp 
        435                 440                 445             
Gly Ala Leu Arg Asn Ala Ile Ala Gln Asn Leu His Phe Val Gln Glu 
    450                 455                 460                 
Val Leu Ile Cys Leu Glu Thr Ser Ala Asn Asp Phe Lys Trp Phe Glu 
465                 470                 475                 480 
Leu Asn Gln Leu Lys Leu Glu Lys Asp Val Phe Phe Trp Glu Leu Lys 
                485                 490                 495     
Gln Met Leu Ala Lys Asn Ala Val Cys Pro Asn Gly Arg Phe Ser Glu 
            500                 505                 510         
Lys Glu Val Phe Leu Pro Pro Gly Asn Ser Ser Ile Trp Gly Gly Leu 
        515                 520                 525             
Gln Gly Leu Leu Cys Tyr Cys Asn Ser Ser Glu Thr Ser Val Leu Asn 
    530                 535                 540                 
Lys Leu Leu Gly Ser Val Glu Asp Ala Asp Arg Ile Leu Gln Glu Val 
545                 550                 555                 560 
Ile Thr Trp His Lys Asn Met Ser Val Leu Ile Pro Glu Glu Tyr Leu 
                565                 570                 575     
Asp Trp Gln Glu Leu Glu Met Gln Leu Ser Glu Ala Ser Leu Ser Cys 
            580                 585                 590         
Thr Arg Leu Phe Leu Leu Leu Gly Ala Asp Pro Ser Pro Glu Asn Asp 
        595                 600                 605             
Val Phe Ser Ser Asp Cys Lys His Gln Leu Val Ser Thr Val Ile Phe 
    610                 615                 620                 
His Thr Leu Glu Lys Thr Gln Phe Phe Leu Glu Gln Ala Tyr Tyr Trp 
625                 630                 635                 640 
Lys Ala Phe Lys Lys Phe Ile Arg Lys Thr Cys Glu Val Ala Gln Tyr 
                645                 650                 655     
Val Asn Met Gln Glu Ser Phe Gln Asn Arg Leu Leu Ala Phe Pro Glu 
            660                 665                 670         
Glu Ser Pro Cys Phe Glu Glu Asn Met Asp Trp Lys Met Ile Ser Asp 
        675                 680                 685             
Asn Tyr Phe Gln Phe Leu Asn Asn Leu Leu Lys Ser Pro Thr Ala Ser 
    690                 695                 700                 
Ile Ser Arg Ala Leu Asn Phe Thr Lys His Leu Leu Met Met Glu Lys 
705                 710                 715                 720 
Lys Leu His Thr Leu Glu Asp Glu Gln Met Asn Phe Leu Leu Ser Phe 
                725                 730                 735     
Val Glu Phe Phe Glu Lys Leu Leu Leu Pro Asn Leu Phe Asp Ser Ser 
            740                 745                 750         
Ile Val Pro Ser Phe His Ser Leu Pro Ser Leu Thr Glu Asp Ile Leu 
        755                 760                 765             
Asn Ile Ser Ser Leu Trp Thr Asn His Leu Lys Ser Leu Lys Arg Asp 
    770                 775                 780                 
Pro Ser Ala Thr Asp Ala Gln Lys Leu Leu Glu Phe Gly Asn Glu Val 
785                 790                 795                 800 
Ile Trp Lys Met Gln Thr Leu Gly Ser His Trp Ile Arg Lys Glu Pro 
                805                 810                 815     
Lys Asn Leu Leu Arg Phe Ile Glu Leu Ile Leu Phe Glu Ile Asn Pro 
            820                 825                 830         
Lys Leu Leu Glu Leu Trp Ala Tyr Gly Ile Ser Lys Gly Lys Arg Ala 
        835                 840                 845             
Lys Leu Glu Asn Phe Phe Thr Leu Leu Asn Phe Ser Val Pro Glu Asn 
    850                 855                 860                 
Glu Ile Leu Ser Thr Ser Phe Asn Phe Ser Gln Leu Phe His Ser Asp 
865                 870                 875                 880 
Trp Pro Lys Ser Pro Ala Met Asn Ile Asp Phe Val Arg Leu Ser Glu 
                885                 890                 895     
Ala Ile Ile Thr Ser Leu His Glu Phe Gly Phe Leu Glu Gln Glu Gln 
            900                 905                 910         
Ile Ser Glu Ala Leu Asn Thr Val Tyr Ala Ile Arg Asn Ala Ser Asp 
        915                 920                 925             
Leu Phe Ser Ala Leu Ser Glu Pro Gln Lys Gln Glu Val Asp Lys Ile 
    930                 935                 940                 
Leu Thr His Ile His Leu Asn Val Phe Gln Asp Lys Asp Ser Ala Leu 
945                 950                 955                 960 
Leu Leu Gln Ile Tyr Ser Ser Phe Tyr Arg Tyr Ile Tyr Glu Leu Leu 
                965                 970                 975     
Asn Ile Gln Ser Arg Gly Ser Ser Leu Thr Phe Leu Thr Gln Ile Ser 
            980                 985                 990         
Lys His Ile Leu Asp Ile Ile Lys Gln Phe Asn Phe Gln Asn Ile Ser 
        995                 1000                1005            
Lys Ala Phe Ala Phe Leu Phe Lys Thr Ala Glu Val Leu Gly Gly Ile 
    1010                1015                1020                
Ser Asn Val Ser Tyr Cys Gln Gln Leu Leu Ser Ile Phe Asn Phe Leu 
1025                1030                1035                1040
Glu Leu Gln Ala Gln Ser Phe Met Ser Thr Glu Gly Gln Glu Leu Glu 
                1045                1050                1055    
Val Ile His Thr Thr Leu Thr Gly Leu Lys Gln Leu Leu Ile Ile Asp 
            1060                1065                1070        
Glu Asp Phe Arg Ile Ser Leu Phe Gln Tyr Met Ser Gln Phe Phe Asn 
        1075                1080                1085            
Ser Ser Val Glu Asp Leu Leu Asp Asn Lys Cys Leu Ile Ser Asp Asn 
    1090                1095                1100                
Lys His Ile Ser Ser Val Asn Tyr Ser Thr Ser Glu Glu Ser Ser Phe 
1105                1110                1115                1120
Val Phe Pro Leu Ala Gln Ile Phe Ser Asn Leu Ser Ala Asn Val Ser 
                1125                1130                1135    
Val Phe Asn Lys Phe Met Ser Ile His Cys Thr Val Ser Trp Leu Gln 
            1140                1145                1150        
Met Trp Thr Glu Ile Trp Glu Thr Ile Ser Gln Leu Phe Lys Phe Asp 
        1155                1160                1165            
Met Asn Val Phe Thr Ser Leu His His Gly Phe Thr Gln Leu Leu Asp 
    1170                1175                1180                
Glu Leu Glu Asp Asp Val Lys Val Ser Lys Ser Cys Gln Gly Ile Leu 
1185                1190                1195                1200
Pro Thr His Asn Val Ala Arg Leu Ile Leu Asn Leu Phe Lys Asn Val 
                1205                1210                1215    
Thr Gln Ala Asn Asp Phe His Asn Trp Glu Asp Phe Leu Asp Leu Arg 
            1220                1225                1230        
Asp Phe Leu Val Ala Leu Gly Asn Ala Leu Val Ser Val Lys Lys Leu 
        1235                1240                1245            
Asn Leu Glu Gln Val Glu Lys Ser Leu Phe Thr Met Glu Ala Ala Leu 
    1250                1255                1260                
His Gln Leu Lys Thr Phe Pro Phe Asn Glu Ser Thr Ser Arg Glu Phe 
1265                1270                1275                1280
Leu Asn Ser Leu Leu Glu Val Phe Ile Glu Phe Ser Ser Thr Ser Glu 
                1285                1290                1295    
Tyr Ile Val Arg Asn Leu Asp Ser Ile Asn Asp Phe Leu Ser Asn Asn 
            1300                1305                1310        
Leu Thr Asn Tyr Gly Glu Lys Phe Glu Asn Ile Ile Thr Glu Leu Arg 
        1315                1320                1325            
Glu Ala Ile Val Phe Leu Arg Asn Val Ser His Asp Arg Asp Leu Phe 
    1330                1335                1340                
Ser Cys Ala Asp Ile Phe Gln Asn Val Thr Glu Cys Ile Leu Glu Asp 
1345                1350                1355                1360
Gly Phe Leu Tyr Val Asn Thr Ser Gln Arg Met Leu Arg Ile Leu Asp 
                1365                1370                1375    
Thr Leu Asn Ser Thr Phe Ser Ser Glu Asn Thr Ile Ser Ser Leu Lys 
            1380                1385                1390        
Gly Cys Ile Val Trp Leu Asp Val Ile Asn His Leu Tyr Leu Leu Ser 
        1395                1400                1405            
Asn Ser Ser Phe Ser Gln Gly His Leu Gln Asn Ile Leu Gly Asn Phe 
    1410                1415                1420                
Arg Asp Ile Glu Asn Lys Met Asn Ser Ile Leu Lys Ile Val Thr Trp 
1425                1430                1435                1440
Val Leu Asn Ile Lys Lys Pro Leu Cys Ser Ser Asn Gly Ser His Ile 
                1445                1450                1455    
Asn Cys Val Asn Ile Tyr Leu Lys Asp Val Thr Asp Phe Leu Asn Ile 
            1460                1465                1470        
Val Leu Thr Thr Val Phe Glu Lys Glu Lys Lys Pro Lys Phe Glu Ile 
        1475                1480                1485            
Leu Leu Ala Leu Leu Asn Asp Ser Thr Lys Gln Val Arg Met Ser Ile 
    1490                1495                1500                
Asn Asn Leu Thr Thr Asp Phe Asp Phe Ala Ser Gln Ser Asn Trp Arg 
1505                1510                1515                1520
Tyr Phe Thr Glu Leu Ile Leu Arg Pro Ile Glu Met Ser Asp Glu Ile 
                1525                1530                1535    
Pro Asn Gln Phe Gln Asn Ile Trp Leu His Leu Ile Thr Leu Gly Lys 
            1540                1545                1550        
Glu Phe Gln Lys Leu Val Lys Gly Ile Tyr Phe Asn Ile Leu Glu Asn 
        1555                1560                1565            
Asn Ser Ser Ser Lys Thr Glu Asn Leu Leu Asn Ile Phe Ala Thr Ser 
    1570                1575                1580                
Pro Lys Glu Lys Asp Val Asn Ser Val Gly Asn Ser Ile Tyr His Leu 
1585                1590                1595                1600
Ala Ser Tyr Leu Ala Phe Ser Leu Ser His Asp Leu Gln Asn Ser Pro 
                1605                1610                1615    
Lys Ile Ile Ile Ser Pro Glu Ile Met Lys Ala Thr Gly Leu Gly Ile 
            1620                1625                1630        
Gln Leu Ile Arg Asp Val Phe Asn Ser Leu Met Pro Val Val His His 
        1635                1640                1645            
Thr Ser Pro Gln Asn Ala Gly Tyr Met Gln Ala Leu Lys Lys Val Thr 
    1650                1655                1660                
Ser Val Met Arg Thr Leu Lys Lys Ala Asp Ile Asp Leu Leu Val Asp 
1665                1670                1675                1680
Gln Leu Glu Gln Val Ser Val Asn Leu Met Asp Phe Phe Lys Asn Ile 
                1685                1690                1695    
Ser Ser Val Gly Thr Gly Asn Leu Val Val Asn Leu Leu Val Gly Leu 
            1700                1705                1710        
Met Glu Lys Phe Ala Asp Ser Ser His Ser Trp Asn Val Asn His Leu 
        1715                1720                1725            
Leu Gln Leu Ser Arg Leu Phe Pro Lys Asp Val Val Asp Ala Val Ile 
    1730                1735                1740                
Asp Val Tyr Tyr Val Leu Pro His Ala Val Arg Leu Leu Gln Gly Val 
1745                1750                1755                1760
Pro Gly Lys Asn Ile Thr Glu Gly Leu Lys Asp Val Tyr Ser Phe Thr 
                1765                1770                1775    
Leu Leu His Gly Ile Thr Ile Ser Asn Ile Thr Lys Glu Asp Phe Ala 
            1780                1785                1790        
Ile Val Ile Lys Ile Leu Leu Asp Thr Ile Glu Leu Val Ser Asp Lys 
        1795                1800                1805            
Pro Asp Ile Ile Ser Glu Ala Leu Ala Cys Phe Pro Val Val Trp Cys 
    1810                1815                1820                
Trp Asn His Thr Asn Ser Gly Phe Arg Gln Asn Ser Lys Ile Asp Pro 
1825                1830                1835                1840
Cys Asn Val His Gly Leu Met Ser Ser Ser Phe Tyr Gly Lys Val Ala 
                1845                1850                1855    
Ser Ile Leu Asp His Phe His Leu Ser Pro Gln Gly Glu Asp Ser Pro 
            1860                1865                1870        
Cys Ser Asn Glu Ser Ser Arg Met Glu Ile Thr Arg Lys Val Val Cys 
        1875                1880                1885            
Ile Ile His Glu Leu Val Asp Trp Asn Ser Ile Leu Leu Glu Leu Ser 
    1890                1895                1900                
Glu Val Phe His Val Asn Ile Ser Leu Val Lys Thr Val Gln Lys Phe 
1905                1910                1915                1920
Trp His Lys Ile Leu Pro Phe Val Pro Pro Ser Ile Asn Gln Thr Arg 
                1925                1930                1935    
Asp Ser Ile Ser Glu Leu Cys Pro Ser Gly Ser Ile Lys Gln Val Ala 
            1940                1945                1950        
Leu Gln Ile Ile Glu Lys Leu Lys Asn Val Asn Phe Thr Lys Val Thr 
        1955                1960                1965            
Ser Gly Glu Asn Ile Leu Asp Lys Leu Ser Ser Leu Asn Lys Ile Leu 
    1970                1975                1980                
Asn Ile Asn Glu Asp Thr Glu Thr Ser Val Gln Asn Ile Ile Ser Ser 
1985                1990                1995                2000
Asn Leu Glu Arg Thr Val Gln Leu Ile Ser Glu Asp Trp Ser Leu Glu 
                2005                2010                2015    
Lys Ser Thr His Asn Leu Leu Ser Leu Phe Met Met Leu Gln Asn Ala 
            2020                2025                2030        
Asn Val Thr Gly Ser Ser Leu Glu Ala Leu Ser Ser Phe Ile Glu Lys 
        2035                2040                2045            
Ser Glu Thr Pro Tyr Asn Phe Glu Glu Leu Trp Pro Lys Phe Gln Gln 
    2050                2055                2060                
Ile Met Lys Asp Leu Thr Gln Asp Phe Arg Ile Arg His Leu Leu Ser 
2065                2070                2075                2080
Glu Met Asn Lys Gly Ile Lys Ser Ile Asn Ser Met Ala Leu Gln Lys 
                2085                2090                2095    
Ile Thr Leu Gln Phe Ala His Phe Leu Glu Ile Leu Asp Ser Pro Ser 
            2100                2105                2110        
Leu Lys Thr Leu Glu Ile Ile Glu Asp Phe Leu Leu Val Thr Lys Asn 
        2115                2120                2125            
Trp Leu Gln Glu Tyr Ala Asn Glu Asp Tyr Ser Arg Met Ile Glu Thr 
    2130                2135                2140                
Leu Phe Ile Pro Val Thr Asn Glu Ser Ser Thr Glu Asp Ile Ala Leu 
2145                2150                2155                2160
Leu Ala Lys Ala Ile Ala Thr Phe Trp Gly Ser Leu Lys Asn Ile Ser 
                2165                2170                2175    
Arg Ala Gly Asn Phe Asp Val Ala Phe Leu Thr His Leu Leu Asn Gln 
            2180                2185                2190        
Glu Gln Leu Thr Asn Phe Ser Val Val Gln Leu Leu Phe Glu Asn Ile 
        2195                2200                2205            
Leu Ile Asn Leu Ile Asn Asn Leu Ala Gly Asn Ser Gln Glu Ala Ala 
    2210                2215                2220                
Trp Asn Leu Asn Asp Thr Asp Leu Gln Ile Met Asn Phe Ile Asn Leu 
2225                2230                2235                2240
Ile Leu Asn His Met Gln Ser Glu Thr Ser Arg Lys Thr Val Leu Ser 
                2245                2250                2255    
Leu Arg Ser Ile Val Asp Phe Thr Glu Gln Phe Leu Lys Thr Phe Phe 
            2260                2265                2270        
Ser Leu Phe Leu Lys Glu Asp Ser Glu Asn Lys Ile Ser Leu Leu Leu 
        2275                2280                2285            
Lys Tyr Phe His Lys Asp Val Ile Ala Glu Met Ser Phe Val Pro Lys 
    2290                2295                2300                
Asp Lys Ile Leu Glu Ile Leu Lys Leu Asp Gln Phe Leu Thr Leu Met 
2305                2310                2315                2320
Ile Gln Asp Arg Leu Met Asn Ile Phe Ser Ser Leu Lys Glu Thr Ile 
                2325                2330                2335    
Tyr His Leu Met Lys Ser Ser Phe Ile Leu Asp Asn Gly Glu Phe Tyr 
            2340                2345                2350        
Phe Asp Thr His Gln Gly Leu Lys Phe Met Gln Asp Leu Phe Asn Ala 
        2355                2360                2365            
Leu Leu Arg Glu Thr Ser Met Lys Asn Lys Thr Glu Asn Asn Ile Asp 
    2370                2375                2380                
Phe Phe Thr Val Val Ser Gln Leu Phe Phe His Val Asn Lys Ser Glu 
2385                2390                2395                2400
Asp Leu Phe Lys Leu Asn Gln Asp Leu Gly Ser Ala Leu His Leu Val 
                2405                2410                2415    
Arg Glu Cys Ser Thr Glu Met Ala Arg Leu Leu Asp Thr Ile Leu His 
            2420                2425                2430        
Ser Pro Asn Lys Asp Phe Tyr Ala Leu Tyr Pro Thr Leu Gln Glu Val 
        2435                2440                2445            
Ile Leu Ala Asn Leu Thr Asp Leu Leu Phe Phe Ile Asn Asn Ser Phe 
    2450                2455                2460                
Pro Leu Arg Asn Arg Ala Thr Leu Glu Ile Thr Lys Arg Leu Val Gly 
2465                2470                2475                2480
Ala Ile Ser Arg Ala Ser Glu Glu Ser His Val Leu Lys Pro Leu Leu 
                2485                2490                2495    
Glu Met Ser Gly Thr Leu Val Met Leu Leu Asn Asp Ser Ala Asp Leu 
            2500                2505                2510        
Arg Asp Leu Ala Thr Ser Met Asp Ser Ile Val Lys Leu Leu Lys Leu 
        2515                2520                2525            
Val Lys Lys Val Ser Gly Lys Met Ser Thr Val Phe Lys Thr His Phe 
    2530                2535                2540                
Ile Ser Asn Thr Lys Asp Ser Val Lys Phe Phe Asp Thr Leu Tyr Ser 
2545                2550                2555                2560
Ile Met Gln Gln Ser Val Gln Asn Leu Val Lys Glu Ile Ala Thr Leu 
                2565                2570                2575    
Lys Lys Ile Asp His Phe Thr Phe Glu Lys Ile Asn Asp Leu Leu Val 
            2580                2585                2590        
Pro Phe Leu Asp Leu Ala Phe Glu Met Ile Gly Val Glu Pro Tyr Ile 
        2595                2600                2605            
Ser Ser Asn Ser Asp Ile Phe Ser Met Ser Pro Ser Ile Leu Ser Tyr 
    2610                2615                2620                
Met Asn Gln Ser Lys Asp Phe Ser Asp Ile Leu Glu Glu Ile Ala Glu 
2625                2630                2635                2640
Phe Leu Thr Ser Val Lys Met Asn Leu Glu Asp Met Arg Ser Leu Ala 
                2645                2650                2655    
Val Ala Phe Asn Asn Glu Thr Gln Thr Phe Ser Met Asp Ser Val Asn 
            2660                2665                2670        
Leu Arg Glu Glu Ile Leu Gly Cys Leu Val Pro Ile Asn Asn Ile Thr 
        2675                2680                2685            
Asn Gln Met Asp Phe Leu Tyr Pro Asn Pro Ile Ser Thr His Ser Gly 
    2690                2695                2700                
Pro Gln Asp Ile Lys Trp Glu Ile Ile His Glu Val Ile Pro Phe Leu 
2705                2710                2715                2720
Asp Lys Ile Leu Ser Gln Asn Ser Thr Glu Ile Gly Ser Phe Leu Lys 
                2725                2730                2735    
Met Val Ile Cys Leu Thr Leu Glu Ala Leu Trp Lys Asn Leu Lys Lys 
            2740                2745                2750        
Asp Asn Trp Asn Val Ser Asn Val Leu Met Thr Phe Thr Gln His Pro 
        2755                2760                2765            
Asn Asn Leu Leu Lys Thr Ile Glu Thr Val Leu Glu Ala Ser Ser Gly 
    2770                2775                2780                
Ile Lys Ser Asp Tyr Glu Gly Asp Leu Asn Lys Ser Leu Tyr Phe Asp 
2785                2790                2795                2800
Thr Pro Leu Ser Gln Asn Ile Thr His His Gln Leu Glu Lys Ala Ile 
                2805                2810                2815    
His Asn Val Leu Ser Arg Ile Ala Leu Trp Arg Lys Gly Leu Leu Phe 
            2820                2825                2830        
Asn Asn Ser Glu Trp Ile Thr Ser Thr Arg Thr Leu Phe Gln Pro Leu 
        2835                2840                2845            
Phe Glu Ile Phe Ile Lys Ala Thr Thr Gly Lys Asn Val Thr Ser Glu 
    2850                2855                2860                
Lys Glu Glu Arg Thr Lys Lys Glu Met Ile Asp Phe Pro Tyr Ser Phe 
2865                2870                2875                2880
Lys Pro Phe Phe Cys Leu Glu Lys Tyr Leu Gly Gly Leu Phe Val Leu 
                2885                2890                2895    
Thr Lys Tyr Trp Gln Gln Ile Pro Leu Thr Asp Gln Ser Val Val Glu 
            2900                2905                2910        
Ile Cys Glu Val Phe Gln Gln Thr Val Lys Pro Ser Glu Ala Met Glu 
        2915                2920                2925            
Met Leu Gln Lys Val Lys Met Met Val Val Arg Val Leu Thr Ile Val 
    2930                2935                2940                
Ala Glu Asn Pro Ser Trp Thr Lys Asp Ile Leu Cys Ala Thr Leu Ser 
2945                2950                2955                2960
Cys Lys Gln Asn Gly Ile Arg His Leu Ile Leu Ser Ala Ile Gln Gly 
                2965                2970                2975    
Val Thr Leu Ala Gln Asp His Phe Gln Glu Ile Glu Lys Ile Trp Ser 
            2980                2985                2990        
Ser Pro Asn Gln Leu Asn Cys Glu Ser Leu Ser Lys Asn Leu Ser Ser 
        2995                3000                3005            
Thr Leu Glu Ser Phe Lys Ser Ser Leu Glu Asn Ala Thr Gly Gln Asp 
    3010                3015                3020                
Cys Thr Ser Gln Pro Arg Leu Glu Thr Val Gln Gln His Leu Tyr Met 
3025                3030                3035                3040
Leu Ala Lys Ser Leu Glu Glu Thr Trp Ser Ser Gly Asn Pro Ile Met 
                3045                3050                3055    
Thr Phe Leu Ser Asn Phe Thr Val Thr Glu Asp Val Lys Ile Lys Asp 
            3060                3065                3070        
Leu Met Lys Asn Ile Thr Lys Leu Thr Glu Glu Leu Arg Ser Ser Ile 
        3075                3080                3085            
Gln Ile Ser Asn Glu Thr Ile His Ser Ile Leu Glu Ala Asn Ile Ser 
    3090                3095                3100                
His Ser Lys Val Leu Phe Ser Ala Leu Thr Val Ala Leu Ser Gly Lys 
3105                3110                3115                3120
Cys Asp Gln Glu Ile Leu His Leu Leu Leu Thr Phe Pro Lys Gly Glu 
                3125                3130                3135    
Lys Ser Trp Ile Ala Ala Glu Glu Leu Cys Ser Leu Pro Gly Ser Lys 
            3140                3145                3150        
Val Tyr Ser Leu Ile Val Leu Leu Ser Arg Asn Leu Asp Val Arg Ala 
        3155                3160                3165            
Phe Ile Tyr Lys Thr Leu Met Pro Ser Glu Ala Asn Gly Leu Leu Asn 
    3170                3175                3180                
Ser Leu Leu Asp Ile Val Ser Ser Leu Ser Ala Leu Leu Ala Lys Ala 
3185                3190                3195                3200
Gln His Val Phe Glu Tyr Leu Pro Glu Phe Leu His Thr Phe Lys Ile 
                3205                3210                3215    
Thr Ala Leu Leu Glu Thr Leu Asp Phe Gln Gln Val Ser Gln Asn Val 
            3220                3225                3230        
Gln Ala Arg Ser Ser Ala Phe Gly Ser Phe Gln Phe Val Met Lys Met 
        3235                3240                3245            
Val Cys Lys Asp Gln Ala Ser Phe Leu Ser Asp Ser Asn Met Phe Ile 
    3250                3255                3260                
Asn Leu Pro Arg Val Lys Glu Leu Leu Glu Asp Asp Lys Glu Lys Phe 
3265                3270                3275                3280
Asn Ile Pro Glu Asp Ser Thr Pro Phe Cys Leu Lys Leu Tyr Gln Glu 
                3285                3290                3295    
Ile Leu Gln Leu Pro Asn Gly Ala Leu Val Trp Thr Phe Leu Lys Pro 
            3300                3305                3310        
Ile Leu His Gly Lys Ile Leu Tyr Thr Pro Asn Thr Pro Glu Ile Asn 
        3315                3320                3325            
Lys Val Ile Gln Lys Ala Asn Tyr Thr Phe Tyr Ile Val Asp Lys Leu 
    3330                3335                3340                
Lys Thr Leu Ser Glu Thr Leu Leu Glu Met Ser Ser Leu Phe Gln Arg 
3345                3350                3355                3360
Ser Gly Ser Gly Gln Met Phe Asn Gln Leu Gln Glu Ala Leu Arg Asn 
                3365                3370                3375    
Lys Phe Val Arg Asn Phe Val Glu Asn Gln Leu His Ile Asp Val Asp 
            3380                3385                3390        
Lys Leu Thr Glu Lys Leu Gln Thr Tyr Gly Gly Leu Leu Asp Glu Met 
        3395                3400                3405            
Phe Asn His Ala Gly Ala Gly Arg Phe Arg Phe Leu Gly Ser Ile Leu 
    3410                3415                3420                
Val Asn Leu Ser Ser Cys Val Ala Leu Asn Arg Phe Gln Ala Leu Gln 
3425                3430                3435                3440
Ser Val Asp Ile Leu Glu Thr Lys Ala His Glu Leu Leu Gln Gln Asn 
                3445                3450                3455    
Ser Phe Leu Ala Ser Ile Ile Phe Ser Asn Ser Leu Phe Asp Lys Asn 
            3460                3465                3470        
Phe Arg Ser Glu Ser Val Lys Leu Pro Pro His Val Ser Tyr Thr Ile 
        3475                3480                3485            
Arg Thr Asn Val Leu Tyr Ser Val Arg Thr Asp Val Val Lys Asn Pro 
    3490                3495                3500                
Ser Trp Lys Phe His Pro Gln Asn Leu Pro Ala Asp Gly Phe Lys Tyr 
3505                3510                3515                3520
Asn Tyr Val Phe Ala Pro Leu Gln Asp Met Ile Glu Arg Ala Ile Ile 
                3525                3530                3535    
Leu Val Gln Thr Gly Gln Glu Ala Leu Glu Pro Ala Ala Gln Thr Gln 
            3540                3545                3550        
Ala Ala Pro Tyr Pro Cys His Thr Ser Asp Leu Phe Leu Asn Asn Val 
        3555                3560                3565            
Gly Phe Phe Phe Pro Leu Ile Met Met Leu Thr Trp Met Val Ser Val 
    3570                3575                3580                
Ala Ser Met Val Arg Lys Leu Val Tyr Glu Gln Glu Ile Gln Ile Glu 
3585                3590                3595                3600
Glu Tyr Met Arg Met Met Gly Val His Pro Val Ile His Phe Leu Ala 
                3605                3610                3615    
Trp Phe Leu Glu Asn Met Ala Val Leu Thr Ile Ser Ser Ala Thr Leu 
            3620                3625                3630        
Ala Ile Val Leu Lys Thr Ser Gly Ile Phe Ala His Ser Asn Thr Phe 
        3635                3640                3645            
Ile Val Phe Leu Phe Leu Leu Asp Phe Gly Met Ser Val Val Met Leu 
    3650                3655                3660                
Ser Tyr Leu Leu Ser Ala Phe Phe Ser Gln Ala Asn Thr Ala Ala Leu 
3665                3670                3675                3680
Cys Thr Ser Leu Val Tyr Met Ile Ser Phe Leu Pro Tyr Ile Val Leu 
                3685                3690                3695    
Leu Val Leu His Asn Gln Leu Ser Phe Val Asn Gln Thr Phe Leu Cys 
            3700                3705                3710        
Leu Leu Ser Thr Thr Ala Phe Gly Gln Gly Val Phe Phe Ile Thr Phe 
        3715                3720                3725            
Leu Glu Gly Gln Glu Thr Gly Ile Gln Trp Asn Asn Met Tyr Gln Ala 
    3730                3735                3740                
Leu Glu Gln Gly Gly Met Thr Phe Gly Trp Val Cys Trp Met Ile Leu 
3745                3750                3755                3760
Phe Asp Ser Ser Leu Tyr Phe Leu Cys Gly Trp Tyr Leu Ser Asn Leu 
                3765                3770                3775    
Ile Pro Gly Thr Phe Gly Leu Arg Lys Pro Trp Tyr Phe Pro Phe Thr 
            3780                3785                3790        
Ala Ser Tyr Trp Lys Ser Val Gly Phe Leu Val Glu Lys Arg Gln Tyr 
        3795                3800                3805            
Phe Leu Ser Ser Ser Leu Phe Phe Phe Asn Glu Asn Phe Asp Asn Lys 
    3810                3815                3820                
Gly Ser Ser Leu Gln Asn Arg Glu Gly Glu Leu Glu Gly Ser Ala Pro 
3825                3830                3835                3840
Gly Val Thr Leu Val Ser Val Thr Lys Glu Tyr Glu Gly His Lys Ala 
                3845                3850                3855    
Val Val Gln Asp Leu Ser Leu Thr Phe Tyr Arg Asp Gln Ile Thr Ala 
            3860                3865                3870        
Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr Thr Ile Ile Ser Met Leu 
        3875                3880                3885            
Thr Gly Leu His Pro Pro Thr Ser Gly Thr Ile Ile Ile Asn Gly Lys 
    3890                3895                3900                
Asn Leu Gln Thr Asp Leu Ser Arg Val Arg Met Glu Leu Gly Val Cys 
3905                3910                3915                3920
Pro Gln Gln Asp Ile Leu Leu Asp Asn Leu Thr Val Arg Glu His Leu 
                3925                3930                3935    
Leu Leu Phe Ala Ser Ile Lys Ala Pro Gln Trp Thr Lys Lys Glu Leu 
            3940                3945                3950        
His Gln Gln Val Asn Gln Thr Leu Gln Asp Val Asp Leu Thr Gln His 
        3955                3960                3965            
Gln His Lys Gln Thr Arg Ala Leu Ser Gly Gly Leu Lys Arg Lys Leu 
    3970                3975                3980                
Ser Leu Gly Ile Ala Phe Met Gly Met Ser Arg Thr Val Val Leu Asp 
3985                3990                3995                4000
Glu Pro Thr Ser Gly Val Asp Pro Cys Ser Arg His Ser Leu Trp Asp 
                4005                4010                4015    
Ile Leu Leu Lys Tyr Arg Glu Gly Arg Thr Ile Ile Phe Thr Thr His 
            4020                4025                4030        
His Leu Asp Glu Ala Glu Ala Leu Ser Asp Arg Val Ala Val Leu Gln 
        4035                4040                4045            
His Gly Arg Leu Arg Cys Cys Gly Pro Pro Phe Cys Leu Lys Glu Ala 
    4050                4055                4060                
Tyr Gly Gln Gly Leu Arg Leu Thr Leu Thr Arg Gln Pro Ser Val Leu 
4065                4070                4075                4080
Glu Ala His Asp Leu Lys Asp Met Ala Cys Val Thr Ser Leu Ile Lys 
                4085                4090                4095    
Ile Tyr Ile Pro Gln Ala Phe Leu Lys Asp Ser Ser Gly Ser Glu Leu 
            4100                4105                4110        
Thr Tyr Thr Ile Pro Lys Asp Thr Asp Lys Ala Cys Leu Lys Gly Leu 
        4115                4120                4125            
Phe Gln Ala Leu Asp Glu Asn Leu His Gln Leu His Leu Thr Gly Tyr 
    4130                4135                4140                
Gly Ile Ser Asp Thr Thr Leu Glu Glu Val Phe Leu Met Leu Leu Gln 
4145                4150                4155                4160
Asp Ser Asn Lys Lys Ser His Ile Ala Leu Gly Thr Glu Ser Glu Leu 
                4165                4170                4175    
Gln Asn His Arg Pro Thr Gly His Leu Ser Gly Tyr Cys Gly Ser Leu 
            4180                4185                4190        
Ala Arg Pro Ala Thr Val Gln Gly Val Gln Leu Leu Arg Ala Gln Val 
        4195                4200                4205            
Ala Ala Ile Leu Ala Arg Arg Leu Arg Arg Thr Leu Arg Ala Gly Lys 
    4210                4215                4220                
Ser Thr Leu Ala Asp Leu Leu Leu Pro Val Leu Phe Val Ala Leu Ala 
4225                4230                4235                4240
Met Gly Leu Phe Met Val Arg Pro Leu Ala Thr Glu Tyr Pro Pro Leu 
                4245                4250                4255    
Arg Leu Thr Pro Gly His Tyr Gln Arg Ala Glu Thr Tyr Phe Phe Ser 
            4260                4265                4270        
Ser Gly Gly Asp Asn Leu Asp Leu Thr Arg Val Leu Leu Arg Lys Phe 
        4275                4280                4285            
Arg Asp Gln Asp Leu Pro Cys Ala Asp Leu Asn Pro Arg Gln Lys Asn 
    4290                4295                4300                
Ser Ser Cys Trp Arg Thr Asp Pro Phe Ser His Pro Glu Phe Gln Asp 
4305                4310                4315                4320
Ser Cys Gly Cys Leu Lys Cys Pro Asn Arg Ser Ala Ser Ala Pro Tyr 
                4325                4330                4335    
Leu Thr Asn His Leu Gly His Thr Leu Leu Asn Leu Ser Gly Phe Asn 
            4340                4345                4350        
Met Glu Glu Tyr Leu Leu Ala Pro Ser Glu Lys Pro Arg Leu Gly Gly 
        4355                4360                4365            
Trp Ser Phe Gly Leu Lys Ile Pro Ser Glu Ala Gly Gly Ala Asn Gly 
    4370                4375                4380                
Asn Ile Ser Lys Pro Pro Thr Leu Ala Lys Val Trp Tyr Asn Gln Lys 
4385                4390                4395                4400
Gly Phe His Ser Leu Pro Ser Tyr Leu Asn His Leu Asn Asn Leu Ile 
                4405                4410                4415    
Leu Trp Gln His Leu Pro Pro Thr Val Asp Trp Arg Gln Tyr Gly Ile 
            4420                4425                4430        
Thr Leu Tyr Ser His Pro Tyr Gly Gly Ala Leu Leu Asn Glu Asp Lys 
        4435                4440                4445            
Ile Leu Glu Ser Ile Arg Gln Cys Gly Val Ala Leu Cys Ile Val Leu 
    4450                4455                4460                
Gly Phe Ser Ile Leu Ser Ala Ser Ile Gly Ser Ser Val Val Arg Asp 
4465                4470                4475                4480
Arg Val Ile Gly Ala Lys Arg Leu Gln His Ile Ser Gly Leu Gly Tyr 
                4485                4490                4495    
Arg Met Tyr Trp Phe Thr Asn Phe Leu Tyr Asp Met Leu Phe Tyr Leu 
            4500                4505                4510        
Val Ser Val Cys Leu Cys Val Ala Val Ile Val Ala Phe Gln Leu Thr 
        4515                4520                4525            
Ala Phe Thr Phe Arg Lys Asn Leu Ala Ala Thr Ala Leu Leu Leu Ser 
    4530                4535                4540                
Leu Phe Gly Tyr Ala Thr Leu Pro Trp Met Tyr Leu Met Ser Arg Ile 
4545                4550                4555                4560
Phe Ser Ser Ser Asp Val Ala Phe Ile Ser Tyr Val Ser Leu Asn Phe 
                4565                4570                4575    
Ile Phe Gly Leu Cys Thr Met Leu Ile Thr Ile Met Pro Arg Leu Leu 
            4580                4585                4590        
Ala Ile Ile Ser Lys Ala Lys Asn Leu Gln Asn Ile Tyr Asp Val Leu 
        4595                4600                4605            
Lys Trp Val Phe Thr Ile Phe Pro Gln Phe Cys Leu Gly Gln Gly Leu 
    4610                4615                4620                
Val Glu Leu Cys Tyr Asn Gln Ile Lys Tyr Asp Leu Thr His Asn Phe 
4625                4630                4635                4640
Gly Ile Asp Ser Tyr Val Ser Pro Phe Glu Met Asn Phe Leu Gly Trp 
                4645                4650                4655    
Ile Phe Val Gln Leu Ala Ser Gln Gly Thr Val Leu Leu Leu Leu Arg 
            4660                4665                4670        
Val Leu Leu His Trp Asp Leu Leu Arg Trp Pro Arg Gly His Ser Thr 
        4675                4680                4685            
Leu Gln Gly Thr Val Lys Ser Ser Lys Asp Thr Asp Val Glu Lys Glu 
    4690                4695                4700                
Glu Lys Arg Val Phe Glu Gly Arg Thr Asn Gly Asp Ile Leu Val Leu 
4705                4710                4715                4720
Tyr Asn Leu Ser Lys His Tyr Arg Arg Phe Phe Gln Asn Ile Ile Ala 
                4725                4730                4735    
Val Gln Asp Ile Ser Leu Gly Ile Pro Lys Gly Glu Cys Phe Gly Leu 
            4740                4745                4750        
Leu Gly Val Asn Gly Ala Gly Lys Ser Thr Thr Phe Lys Met Leu Asn 
        4755                4760                4765            
Gly Glu Val Ser Leu Thr Ser Gly His Ala Ile Ile Arg Thr Pro Met 
    4770                4775                4780                
Gly Asp Ala Val Asp Leu Ser Ser Ala Gly Thr Ala Gly Val Leu Ile 
4785                4790                4795                4800
Gly Tyr Cys Pro Gln Gln Asp Ala Leu Asp Glu Leu Leu Thr Gly Trp 
                4805                4810                4815    
Glu His Leu Tyr Tyr Tyr Cys Ser Leu Arg Gly Ile Pro Arg Gln Cys 
            4820                4825                4830        
Ile Pro Glu Val Ala Gly Asp Leu Ile Arg Arg Leu His Leu Glu Ala 
        4835                4840                4845            
His Ala Asp Lys Pro Val Ala Thr Tyr Ser Gly Gly Thr Lys Arg Lys 
    4850                4855                4860                
Leu Ser Thr Ala Leu Ala Leu Val Gly Lys Pro Asp Ile Leu Leu Leu 
4865                4870                4875                4880
Asp Glu Pro Ser Ser Gly Met Asp Pro Cys Ser Lys Arg Tyr Leu Trp 
                4885                4890                4895    
Gln Thr Ile Met Lys Glu Val Arg Glu Gly Cys Ala Ala Val Leu Thr 
            4900                4905                4910        
Ser His Ser Met Glu Glu Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile 
        4915                4920                4925            
Met Val Asn Gly Ser Phe Lys Cys Leu Gly Ser Pro Gln His Ile Lys 
    4930                4935                4940                
Asn Arg Phe Gly Asp Gly Tyr Thr Val Lys Val Trp Leu Cys Lys Glu 
4945                4950                4955                4960
Ala Asn Gln His Cys Thr Val Ser Asp His Leu Lys Leu Tyr Phe Pro 
                4965                4970                4975    
Gly Ile Gln Phe Lys Gly Gln His Leu Asn Leu Leu Glu Tyr His Val 
            4980                4985                4990        
Pro Lys Arg Trp Gly Cys Leu Ala Asp Leu Phe Lys Val Ile Glu Asn 
        4995                5000                5005            
Asn Lys Thr Phe Leu Asn Ile Lys His Tyr Ser Ile Asn Gln Thr Thr 
    5010                5015                5020                
Leu Glu Gln Val Phe Ile Asn Phe Ala Ser Glu Gln Gln Gln Thr Leu 
5025                5030                5035                5040
Gln Ser Thr Leu Asp Pro Ser Thr Asp Ser His His Thr His His Leu 
                5045                5050                5055    
Pro Ile 
        

<210> 13
<211> 2073
<212> DNA
<213> Homo sapiens


<400> 13
atgaaactat ccatgaagaa caatattatc aatacacagc agtcttttgt aaccatgccc      60

aatgtgattg taccagatat tgaaaaggaa atacgaagga tggaaaatgg agcatgcagc     120

tccttttctg aggatgatga cagtgcctct acatctgaag aatcagagaa tgaaaaccct     180

catgcaaggg gttcctttag ttataagtca ctcagaaagg gaggaccatc acagagggag     240

cagtacctgc ctggtgccat tgcacttttt aatgtgaaca acagcagcaa taaggaccag     300

gaaccagaag aaaaaaagaa aaagaaaaaa gaaaagaaga gcaagtcaga tgataaaaac     360

gaaaataaaa acgacccaga gaagaaaaag aagaaaaagg acaaagagaa gaaaaagaaa     420

gaggagaaaa gcaaagataa gaaagaagag gagaagaaag aagttgtggt tattgatccc     480

tcgggaaaca catattacaa ctggctgttt tgcatcacat tacctgttat gtacaactgg     540

acaatggtta ttgccagagc atgttttgat gaacttcaat ctgattacct agaatattgg     600

ctcattttgg attacgtatc agacatagtc tatttaatcg atatgtttgt acgaacaagg     660

acaggttacc tagaacaagg actgctggta aaggaagaac ttaaactcat aaataaatat     720

aaatccaact tgcaatttaa acttgatgtt ctgtcactga taccaactga tttgctgtat     780

tttaagttag ggtggaacta tccagaaatt agattaaaca ggttgttacg gttctctcgt     840

atgtttgagt tcttccagag aacagaaaca aggacaaact atccaaacat cttcaggatt     900

tccaaccttg ttatgtatat cgtcatcatt atccactgga atgcatgtgt gttctactct     960

atttctaaag ctattggatt tggaaatgat acatgggtct accctgatat taatgatcct    1020

gaatttggcc gtttggctag aaaatacgta tacagccttt actggtctac actgactttg    1080

actaccattg gtgaaacacc ccctcccgtg agggattctg agtatgtctt tgtggtggtt    1140

gatttcctaa ttggagtgtt aatttttgct accatcgttg gtaacatagg ttctatgatt    1200

tccaacatga atgcagccag agcagaattt caagcaagaa ttgatgctat caagcaatat    1260

atgcattttc gaaatgtaag caaagatatg gaaaagaggg ttattaaatg gtttgactac    1320

ctgtggacca acaaaaaaac agttgatgag aaagaagtct taaagtatct acctgataaa    1380

ctaagagcag aaattgccat caacgttcac ttagacacat taaaaaaggt acgcattttt    1440

gctgattgtg aagctggtct gttggtggag ttggtcttga aattgcaacc ccaagtctac    1500

agtcctggag attatatttg caagaaaggg gatatcggac gagagatgta cattatcaag    1560

gaaggcaaac tcgctgtggt ggcagatgat ggagtcactc agtttgtggt attgagcgat    1620

ggcagctact tcggtgagat cagcattctt aacattaaag ggagcaaagc tggcaatcga    1680

agaacggcca atattaaaag tattggctac tcagacctgt tctgtctctc aaaagatgac    1740

ctcatggaag ctctaactga gtacccagat gccaaaacta tgctggaaga gaaagggaag    1800

cagattttaa tgaaagatgg tctactggat ctaaacattg caaatgctgg cagtgatcct    1860

aaagatcttg aagagaaggt tactcgaatg gaggggtcag tagacctcct gcaaaccagg    1920

tttgcccgaa tcttggctga gtatgagtcc atgcagcaga aactgaaaca aagattaacc    1980

aaggttgaga aatttctgaa accgcttatt gacacagaat tttcaagtat tgagggacct    2040

ggagcggaaa gtgggcccat cgactctaca tag                                 2073


<210> 14
<211> 690
<212> PRT
<213> Homo sapiens


<400> 14
Met Lys Leu Ser Met Lys Asn Asn Ile Ile Asn Thr Gln Gln Ser Phe 
1               5                   10                  15      
Val Thr Met Pro Asn Val Ile Val Pro Asp Ile Glu Lys Glu Ile Arg 
            20                  25                  30          
Arg Met Glu Asn Gly Ala Cys Ser Ser Phe Ser Glu Asp Asp Asp Ser 
        35                  40                  45              
Ala Ser Thr Ser Glu Glu Ser Glu Asn Glu Asn Pro His Ala Arg Gly 
    50                  55                  60                  
Ser Phe Ser Tyr Lys Ser Leu Arg Lys Gly Gly Pro Ser Gln Arg Glu 
65                  70                  75                  80  
Gln Tyr Leu Pro Gly Ala Ile Ala Leu Phe Asn Val Asn Asn Ser Ser 
                85                  90                  95      
Asn Lys Asp Gln Glu Pro Glu Glu Lys Lys Lys Lys Lys Lys Glu Lys 
            100                 105                 110         
Lys Ser Lys Ser Asp Asp Lys Asn Glu Asn Lys Asn Asp Pro Glu Lys 
        115                 120                 125             
Lys Lys Lys Lys Lys Asp Lys Glu Lys Lys Lys Lys Glu Glu Lys Ser 
    130                 135                 140                 
Lys Asp Lys Lys Glu Glu Glu Lys Lys Glu Val Val Val Ile Asp Pro 
145                 150                 155                 160 
Ser Gly Asn Thr Tyr Tyr Asn Trp Leu Phe Cys Ile Thr Leu Pro Val 
                165                 170                 175     
Met Tyr Asn Trp Thr Met Val Ile Ala Arg Ala Cys Phe Asp Glu Leu 
            180                 185                 190         
Gln Ser Asp Tyr Leu Glu Tyr Trp Leu Ile Leu Asp Tyr Val Ser Asp 
        195                 200                 205             
Ile Val Tyr Leu Ile Asp Met Phe Val Arg Thr Arg Thr Gly Tyr Leu 
    210                 215                 220                 
Glu Gln Gly Leu Leu Val Lys Glu Glu Leu Lys Leu Ile Asn Lys Tyr 
225                 230                 235                 240 
Lys Ser Asn Leu Gln Phe Lys Leu Asp Val Leu Ser Leu Ile Pro Thr 
                245                 250                 255     
Asp Leu Leu Tyr Phe Lys Leu Gly Trp Asn Tyr Pro Glu Ile Arg Leu 
            260                 265                 270         
Asn Arg Leu Leu Arg Phe Ser Arg Met Phe Glu Phe Phe Gln Arg Thr 
        275                 280                 285             
Glu Thr Arg Thr Asn Tyr Pro Asn Ile Phe Arg Ile Ser Asn Leu Val 
    290                 295                 300                 
Met Tyr Ile Val Ile Ile Ile His Trp Asn Ala Cys Val Phe Tyr Ser 
305                 310                 315                 320 
Ile Ser Lys Ala Ile Gly Phe Gly Asn Asp Thr Trp Val Tyr Pro Asp 
                325                 330                 335     
Ile Asn Asp Pro Glu Phe Gly Arg Leu Ala Arg Lys Tyr Val Tyr Ser 
            340                 345                 350         
Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu Thr Pro Pro 
        355                 360                 365             
Pro Val Arg Asp Ser Glu Tyr Val Phe Val Val Val Asp Phe Leu Ile 
    370                 375                 380                 
Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Ile Gly Ser Met Ile 
385                 390                 395                 400 
Ser Asn Met Asn Ala Ala Arg Ala Glu Phe Gln Ala Arg Ile Asp Ala 
                405                 410                 415     
Ile Lys Gln Tyr Met His Phe Arg Asn Val Ser Lys Asp Met Glu Lys 
            420                 425                 430         
Arg Val Ile Lys Trp Phe Asp Tyr Leu Trp Thr Asn Lys Lys Thr Val 
        435                 440                 445             
Asp Glu Lys Glu Val Leu Lys Tyr Leu Pro Asp Lys Leu Arg Ala Glu 
    450                 455                 460                 
Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val Arg Ile Phe 
465                 470                 475                 480 
Ala Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu Lys Leu Gln 
                485                 490                 495     
Pro Gln Val Tyr Ser Pro Gly Asp Tyr Ile Cys Lys Lys Gly Asp Ile 
            500                 505                 510         
Gly Arg Glu Met Tyr Ile Ile Lys Glu Gly Lys Leu Ala Val Val Ala 
        515                 520                 525             
Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly Ser Tyr Phe 
    530                 535                 540                 
Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ala Gly Asn Arg 
545                 550                 555                 560 
Arg Thr Ala Asn Ile Lys Ser Ile Gly Tyr Ser Asp Leu Phe Cys Leu 
                565                 570                 575     
Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro Asp Ala Lys 
            580                 585                 590         
Thr Met Leu Glu Glu Lys Gly Lys Gln Ile Leu Met Lys Asp Gly Leu 
        595                 600                 605             
Leu Asp Leu Asn Ile Ala Asn Ala Gly Ser Asp Pro Lys Asp Leu Glu 
    610                 615                 620                 
Glu Lys Val Thr Arg Met Glu Gly Ser Val Asp Leu Leu Gln Thr Arg 
625                 630                 635                 640 
Phe Ala Arg Ile Leu Ala Glu Tyr Glu Ser Met Gln Gln Lys Leu Lys 
                645                 650                 655     
Gln Arg Leu Thr Lys Val Glu Lys Phe Leu Lys Pro Leu Ile Asp Thr 
            660                 665                 670         
Glu Phe Ser Ser Ile Glu Gly Pro Gly Ala Glu Ser Gly Pro Ile Asp 
        675                 680                 685             
Ser Thr 
    690 

<210> 15
<211> 1995
<212> DNA
<213> Homo sapiens


<400> 15
atgaccgaaa aaaccaatgg tgtgaagagc tccccagcca ataatcacaa ccatcatgca      60

cctcctgcca tcaaggccaa tggcaaagat gaccacagga caagcagcag gccacactct     120

gcagctgacg atgacacctc ctcagaactg cagaggctgg cagacgtgga tgccccacag     180

cagggaagga gtggcttccg caggatagtt cgcctggtgg ggatcatcag agaatgggcc     240

aacaagaatt tccgagagga ggaacctagg cctgactcat tcctcgagcg ttttcgtggg     300

cctgaactcc agactgtgac cacacaggag ggggatggca aaggcgacaa ggatggcgag     360

gacaaaggca ccaagaagaa atttgaacta tttgtcttgg acccagctgg ggattggtac     420

tactgctggc tatttgtcat tgccatgccc gtcctttaca actggtgcct gctggtggcc     480

agagcctgct tcagtgacct acagaaaggc tactacctgg tgtggctggt gctggattat     540

gtctcagatg tggtctacat tgcggacctc ttcatccgat tgcgcacagg tttcctggag     600

caggggctgc tggtcaaaga taccaagaaa ctgcgagaca actacatcca caccctgcag     660

ttcaagctgg atgtggcttc catcatcccc actgacctga tctattttgc tgtggacatc     720

cacagccctg aggtgcgctt caaccgcctg ctgcactttg cccgcatgtt tgagttcttt     780

gaccggacag agacacgcac caactaccct aacatcttcc gcatcagcaa ccttgtcctc     840

tacatcttgg tcatcatcca ctggaatgcc tgcatctatt atgccatctc caaatccata     900

ggctttgggg tcgacacctg ggtttaccca aacatcactg accctgagta tggctacctg     960

gctagggaat acatctattg cctttactgg tccacactga ctctcactac cattggggag    1020

acaccacccc ctgtaaagga tgaggagtac ctatttgtca tctttgactt cctgattggc    1080

gtcctcatct ttgccaccat cgtgggaaat gtgggctcca tgatctccaa catgaatgcc    1140

acccgggcag agttccaggc taagatcgat gccgtgaaac actacatgca gttccgaaag    1200

gtcagcaagg ggatggaagc caaggtcatt aggtggtttg actacttgtg gaccaataag    1260

aagacagtgg atgagcgaga aattctcaag aatctgccag ccaagctcag ggctgagata    1320

gccatcaatg tccacttgtc cacactcaag aaagtgcgca tcttccatga ttgtgaggct    1380

ggcctgctgg tagagctggt actgaaactc cgtcctcagg tcttcagtcc tggggattac    1440

atttgccgca aaggggacat cggcaaggag atgtacatca ttaaggaggg caaactggca    1500

gtggtggctg atgatggtgt gactcagtat gctctgctgt cggctggaag ctgctttggc    1560

gagatcagta tccttaacat taagggcagt aaaatgggca atcgacgcac agctaatatc    1620

cgcagcctgg gctactcaga tctcttctgc ttgtccaagg atgatcttat ggaagctgtg    1680

actgagtacc ctgatgccaa gaaagtccta gaagagaggg gtcgggagat cctcatgaag    1740

gagggactgc tggatgagaa cgaagtggca accagcatgg aggtcgacgt gcaggagaag    1800

ctagggcagc tggagaccaa catggaaacc ttgtacactc gctttggccg cctgctggct    1860

gagtacacgg gggcccagca gaagctcaag cagcgcatca cagttctgga aaccaagatg    1920

aaacagaaca atgaagatga ctacctgtct gatgggatga acagccctga gctggctgct    1980

gctgacgagc cataa                                                     1995


<210> 16
<211> 664
<212> PRT
<213> Homo sapiens


<400> 16
Met Thr Glu Lys Thr Asn Gly Val Lys Ser Ser Pro Ala Asn Asn His 
1               5                   10                  15      
Asn His His Ala Pro Pro Ala Ile Lys Ala Asn Gly Lys Asp Asp His 
            20                  25                  30          
Arg Thr Ser Ser Arg Pro His Ser Ala Ala Asp Asp Asp Thr Ser Ser 
        35                  40                  45              
Glu Leu Gln Arg Leu Ala Asp Val Asp Ala Pro Gln Gln Gly Arg Ser 
    50                  55                  60                  
Gly Phe Arg Arg Ile Val Arg Leu Val Gly Ile Ile Arg Glu Trp Ala 
65                  70                  75                  80  
Asn Lys Asn Phe Arg Glu Glu Glu Pro Arg Pro Asp Ser Phe Leu Glu 
                85                  90                  95      
Arg Phe Arg Gly Pro Glu Leu Gln Thr Val Thr Thr Gln Glu Gly Asp 
            100                 105                 110         
Gly Lys Gly Asp Lys Asp Gly Glu Asp Lys Gly Thr Lys Lys Lys Phe 
        115                 120                 125             
Glu Leu Phe Val Leu Asp Pro Ala Gly Asp Trp Tyr Tyr Cys Trp Leu 
    130                 135                 140                 
Phe Val Ile Ala Met Pro Val Leu Tyr Asn Trp Cys Leu Leu Val Ala 
145                 150                 155                 160 
Arg Ala Cys Phe Ser Asp Leu Gln Lys Gly Tyr Tyr Leu Val Trp Leu 
                165                 170                 175     
Val Leu Asp Tyr Val Ser Asp Val Val Tyr Ile Ala Asp Leu Phe Ile 
            180                 185                 190         
Arg Leu Arg Thr Gly Phe Leu Glu Gln Gly Leu Leu Val Lys Asp Thr 
        195                 200                 205             
Lys Lys Leu Arg Asp Asn Tyr Ile His Thr Leu Gln Phe Lys Leu Asp 
    210                 215                 220                 
Val Ala Ser Ile Ile Pro Thr Asp Leu Ile Tyr Phe Ala Val Asp Ile 
225                 230                 235                 240 
His Ser Pro Glu Val Arg Phe Asn Arg Leu Leu His Phe Ala Arg Met 
                245                 250                 255     
Phe Glu Phe Phe Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Ile 
            260                 265                 270         
Phe Arg Ile Ser Asn Leu Val Leu Tyr Ile Leu Val Ile Ile His Trp 
        275                 280                 285             
Asn Ala Cys Ile Tyr Tyr Ala Ile Ser Lys Ser Ile Gly Phe Gly Val 
    290                 295                 300                 
Asp Thr Trp Val Tyr Pro Asn Ile Thr Asp Pro Glu Tyr Gly Tyr Leu 
305                 310                 315                 320 
Ala Arg Glu Tyr Ile Tyr Cys Leu Tyr Trp Ser Thr Leu Thr Leu Thr 
                325                 330                 335     
Thr Ile Gly Glu Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe 
            340                 345                 350         
Val Ile Phe Asp Phe Leu Ile Gly Val Leu Ile Phe Ala Thr Ile Val 
        355                 360                 365             
Gly Asn Val Gly Ser Met Ile Ser Asn Met Asn Ala Thr Arg Ala Glu 
    370                 375                 380                 
Phe Gln Ala Lys Ile Asp Ala Val Lys His Tyr Met Gln Phe Arg Lys 
385                 390                 395                 400 
Val Ser Lys Gly Met Glu Ala Lys Val Ile Arg Trp Phe Asp Tyr Leu 
                405                 410                 415     
Trp Thr Asn Lys Lys Thr Val Asp Glu Arg Glu Ile Leu Lys Asn Leu 
            420                 425                 430         
Pro Ala Lys Leu Arg Ala Glu Ile Ala Ile Asn Val His Leu Ser Thr 
        435                 440                 445             
Leu Lys Lys Val Arg Ile Phe His Asp Cys Glu Ala Gly Leu Leu Val 
    450                 455                 460                 
Glu Leu Val Leu Lys Leu Arg Pro Gln Val Phe Ser Pro Gly Asp Tyr 
465                 470                 475                 480 
Ile Cys Arg Lys Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Lys Glu 
                485                 490                 495     
Gly Lys Leu Ala Val Val Ala Asp Asp Gly Val Thr Gln Tyr Ala Leu 
            500                 505                 510         
Leu Ser Ala Gly Ser Cys Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys 
        515                 520                 525             
Gly Ser Lys Met Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Leu Gly 
    530                 535                 540                 
Tyr Ser Asp Leu Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Val 
545                 550                 555                 560 
Thr Glu Tyr Pro Asp Ala Lys Lys Val Leu Glu Glu Arg Gly Arg Glu 
                565                 570                 575     
Ile Leu Met Lys Glu Gly Leu Leu Asp Glu Asn Glu Val Ala Thr Ser 
            580                 585                 590         
Met Glu Val Asp Val Gln Glu Lys Leu Gly Gln Leu Glu Thr Asn Met 
        595                 600                 605             
Glu Thr Leu Tyr Thr Arg Phe Gly Arg Leu Leu Ala Glu Tyr Thr Gly 
    610                 615                 620                 
Ala Gln Gln Lys Leu Lys Gln Arg Ile Thr Val Leu Glu Thr Lys Met 
625                 630                 635                 640 
Lys Gln Asn Asn Glu Asp Asp Tyr Leu Ser Asp Gly Met Asn Ser Pro 
                645                 650                 655     
Glu Leu Ala Ala Ala Asp Glu Pro 
            660                 

<210> 17
<211> 2085
<212> DNA
<213> Homo sapiens


<400> 17
atggccaaga tcaacaccca atactcccac ccctccagga cccacctcaa ggtaaagacc      60

tcagaccgag atctcaatcg cgctgaaaat ggcctcagca gagcccactc gtcaagtgag     120

gagacatcgt cagtgctgca gccggggatc gccatggaga ccagaggact ggctgactcc     180

gggcagggct ccttcaccgg ccaggggatc gccaggctgt cgcgcctcat cttcttgctg     240

cgcaggtggg ctgccaggca tgtgcaccac caggaccagg gaccggactc ttttcctgat     300

cgtttccgtg gagccgagct taaggaggtg tccagccaag aaagcaatgc ccaggcaaat     360

gtgggcagcc aggagccagc agacagaggg agaagcgcct ggcccctggc caaatgcaac     420

actaacacca gcaacaacac ggaggaggag aagaagacga aaaagaagga tgcgatcgtg     480

gtggacccgt ccagcaacct gtactaccgc tggctgaccg ccatcgccct gcctgtcttc     540

tataactggt atctgcttat ttgcagggcc tgtttcgatg agctgcagtc cgagtacctg     600

atgctgtggc tggtcctgga ctactcggca gatgtcctgt atgtcttgga tgtgcttgta     660

cgagctcgga caggttttct cgagcaaggc ttaatggtca gtgataccaa caggctgtgg     720

cagcattaca agacgaccac gcagttcaag ctggatgtgt tgtccctggt ccccaccgac     780

ctggcttact taaaggtggg cacaaactac ccagaagtga ggttcaaccg cctactgaag     840

ttttcccggc tctttgaatt ctttgaccgc acagagacaa ggaccaacta ccccaatatg     900

ttcaggattg ggaacttggt cttgtacatt ctcatcatca tccactggaa tgcctgcatc     960

tactttgcca tttccaagtt cattggtttt gggacagact cctgggtcta cccaaacatc    1020

tcaatcccag agcatgggcg cctctccagg aagtacattt acagtctcta ctggtccacc    1080

ttgaccctta ccaccattgg tgagacccca ccccccgtga aagatgagga gtatctcttt    1140

gtggtcgtag acttcttggt gggtgttctg atttttgcca ccattgtggg caatgtgggc    1200

tccatgatct cgaatatgaa tgcctcacgg gcagagttcc aggccaagat tgattccatc    1260

aagcagtaca tgcagttccg caaggtcacc aaggacttgg agacgcgggt tatccggtgg    1320

tttgactacc tgtgggccaa caagaagacg gtggatgaga aggaggtgct caagagcctc    1380

ccagacaagc tgaaggctga gatcgccatc aacgtgcacc tggacacgct gaagaaggtt    1440

cgcatcttcc aggactgtga ggcagggctg ctggtggagc tggtgctgaa gctgcgaccc    1500

actgtgttca gccctgggga ttatatctgc aagaagggag atattgggaa ggagatgtac    1560

atcatcaacg agggcaagct ggccgtggtg gctgatgatg gggtcaccca gttcgtggtc    1620

ctcagcgatg gcagctactt cggggagatc agcattctga acatcaaggg gagcaagtcg    1680

gggaaccgca ggacggccaa catccgcagc attggctact cagacctgtt ctgcctctca    1740

aaggacgatc tcatggaggc cctcaccgag taccccgaag ccaagaaggc cctggaggag    1800

aaaggacggc agatcctgat gaaagacaac ctgatcgatg aggagctggc cagggcgggc    1860

gcggacccca aggaccttga ggagaaagtg gagcagctgg ggtcctccct ggacaccctg    1920

cagaccaggt ttgcacgcct cctggctgag tacaacgcca cccagatgaa gatgaagcag    1980

cgtctcagcc aactggaaag ccaggtgaag ggtggtgggg acaagcccct ggctgatggg    2040

gaagttcccg gggatgctac aaaaacagag gacaaacaac agtga                    2085


<210> 18
<211> 694
<212> PRT
<213> Homo sapiens


<400> 18
Met Ala Lys Ile Asn Thr Gln Tyr Ser His Pro Ser Arg Thr His Leu 
1               5                   10                  15      
Lys Val Lys Thr Ser Asp Arg Asp Leu Asn Arg Ala Glu Asn Gly Leu 
            20                  25                  30          
Ser Arg Ala His Ser Ser Ser Glu Glu Thr Ser Ser Val Leu Gln Pro 
        35                  40                  45              
Gly Ile Ala Met Glu Thr Arg Gly Leu Ala Asp Ser Gly Gln Gly Ser 
    50                  55                  60                  
Phe Thr Gly Gln Gly Ile Ala Arg Leu Ser Arg Leu Ile Phe Leu Leu 
65                  70                  75                  80  
Arg Arg Trp Ala Ala Arg His Val His His Gln Asp Gln Gly Pro Asp 
                85                  90                  95      
Ser Phe Pro Asp Arg Phe Arg Gly Ala Glu Leu Lys Glu Val Ser Ser 
            100                 105                 110         
Gln Glu Ser Asn Ala Gln Ala Asn Val Gly Ser Gln Glu Pro Ala Asp 
        115                 120                 125             
Arg Gly Arg Ser Ala Trp Pro Leu Ala Lys Cys Asn Thr Asn Thr Ser 
    130                 135                 140                 
Asn Asn Thr Glu Glu Glu Lys Lys Thr Lys Lys Lys Asp Ala Ile Val 
145                 150                 155                 160 
Val Asp Pro Ser Ser Asn Leu Tyr Tyr Arg Trp Leu Thr Ala Ile Ala 
                165                 170                 175     
Leu Pro Val Phe Tyr Asn Trp Tyr Leu Leu Ile Cys Arg Ala Cys Phe 
            180                 185                 190         
Asp Glu Leu Gln Ser Glu Tyr Leu Met Leu Trp Leu Val Leu Asp Tyr 
        195                 200                 205             
Ser Ala Asp Val Leu Tyr Val Leu Asp Val Leu Val Arg Ala Arg Thr 
    210                 215                 220                 
Gly Phe Leu Glu Gln Gly Leu Met Val Ser Asp Thr Asn Arg Leu Trp 
225                 230                 235                 240 
Gln His Tyr Lys Thr Thr Thr Gln Phe Lys Leu Asp Val Leu Ser Leu 
                245                 250                 255     
Val Pro Thr Asp Leu Ala Tyr Leu Lys Val Gly Thr Asn Tyr Pro Glu 
            260                 265                 270         
Val Arg Phe Asn Arg Leu Leu Lys Phe Ser Arg Leu Phe Glu Phe Phe 
        275                 280                 285             
Asp Arg Thr Glu Thr Arg Thr Asn Tyr Pro Asn Met Phe Arg Ile Gly 
    290                 295                 300                 
Asn Leu Val Leu Tyr Ile Leu Ile Ile Ile His Trp Asn Ala Cys Ile 
305                 310                 315                 320 
Tyr Phe Ala Ile Ser Lys Phe Ile Gly Phe Gly Thr Asp Ser Trp Val 
                325                 330                 335     
Tyr Pro Asn Ile Ser Ile Pro Glu His Gly Arg Leu Ser Arg Lys Tyr 
            340                 345                 350         
Ile Tyr Ser Leu Tyr Trp Ser Thr Leu Thr Leu Thr Thr Ile Gly Glu 
        355                 360                 365             
Thr Pro Pro Pro Val Lys Asp Glu Glu Tyr Leu Phe Val Val Val Asp 
    370                 375                 380                 
Phe Leu Val Gly Val Leu Ile Phe Ala Thr Ile Val Gly Asn Val Gly 
385                 390                 395                 400 
Ser Met Ile Ser Asn Met Asn Ala Ser Arg Ala Glu Phe Gln Ala Lys 
                405                 410                 415     
Ile Asp Ser Ile Lys Gln Tyr Met Gln Phe Arg Lys Val Thr Lys Asp 
            420                 425                 430         
Leu Glu Thr Arg Val Ile Arg Trp Phe Asp Tyr Leu Trp Ala Asn Lys 
        435                 440                 445             
Lys Thr Val Asp Glu Lys Glu Val Leu Lys Ser Leu Pro Asp Lys Leu 
    450                 455                 460                 
Lys Ala Glu Ile Ala Ile Asn Val His Leu Asp Thr Leu Lys Lys Val 
465                 470                 475                 480 
Arg Ile Phe Gln Asp Cys Glu Ala Gly Leu Leu Val Glu Leu Val Leu 
                485                 490                 495     
Lys Leu Arg Pro Thr Val Phe Ser Pro Gly Asp Tyr Ile Cys Lys Lys 
            500                 505                 510         
Gly Asp Ile Gly Lys Glu Met Tyr Ile Ile Asn Glu Gly Lys Leu Ala 
        515                 520                 525             
Val Val Ala Asp Asp Gly Val Thr Gln Phe Val Val Leu Ser Asp Gly 
    530                 535                 540                 
Ser Tyr Phe Gly Glu Ile Ser Ile Leu Asn Ile Lys Gly Ser Lys Ser 
545                 550                 555                 560 
Gly Asn Arg Arg Thr Ala Asn Ile Arg Ser Ile Gly Tyr Ser Asp Leu 
                565                 570                 575     
Phe Cys Leu Ser Lys Asp Asp Leu Met Glu Ala Leu Thr Glu Tyr Pro 
            580                 585                 590         
Glu Ala Lys Lys Ala Leu Glu Glu Lys Gly Arg Gln Ile Leu Met Lys 
        595                 600                 605             
Asp Asn Leu Ile Asp Glu Glu Leu Ala Arg Ala Gly Ala Asp Pro Lys 
    610                 615                 620                 
Asp Leu Glu Glu Lys Val Glu Gln Leu Gly Ser Ser Leu Asp Thr Leu 
625                 630                 635                 640 
Gln Thr Arg Phe Ala Arg Leu Leu Ala Glu Tyr Asn Ala Thr Gln Met 
                645                 650                 655     
Lys Met Lys Gln Arg Leu Ser Gln Leu Glu Ser Gln Val Lys Gly Gly 
            660                 665                 670         
Gly Asp Lys Pro Leu Ala Asp Gly Glu Val Pro Gly Asp Ala Thr Lys 
        675                 680                 685             
Thr Glu Asp Lys Gln Gln 
    690                 

<210> 19
<211> 1728
<212> DNA
<213> Homo sapiens


<400> 19
atgagccagg acaccaaagt gaagacaaca gagtccagtc ccccagcccc atccaaggcc      60

aggaagttgc tgcctgtcct ggacccatct ggggattact actactggtg gctgaacaca     120

atggtcttcc cagtcatgta taacctcatc atcctcgtgt gcagagcctg cttccccgac     180

ttgcagcacg gttatctggt ggcctggttg gtgctggact acacgagtga cctgctatac     240

ctactagaca tggtggtgcg cttccacaca ggattcttgg aacagggcat cctggtggtg     300

gacaagggta ggatctcgag tcgctacgtt cgcacctgga gtttcttctt ggacctggct     360

tccctgatgc ccacagatgt ggtctacgtg cggctgggcc cgcacacacc caccctgagg     420

ctgaaccgct ttctccgcgc gccccgcctc ttcgaggcct tcgaccgcac agagacccgc     480

acagcttacc caaatgcctt tcgcattgcc aagctgatgc tttacatttt tgtcgtcatc     540

cattggaaca gctgcctata ctttgcccta tcccggtacc tgggcttcgg gcgtgacgca     600

tgggtgtacc cggaccccgc gcagcctggc tttgagcgcc tgcggcgcca gtacctctat     660

agcttttact tctccacgct gatactgact acagtgggcg atacaccgcc gccagccagg     720

gaagaagagt acctcttcat ggtgggcgac ttcctgctgg ccgtcatggg tttcgccacc     780

atcatgggta gcatgagctc tgtcatctac aacatgaaca ctgcagatgc ggctttctac     840

ccagatcatg cactggtgaa gaagtacatg aagctgcagc acgtcaaccg caagctggag     900

cggcgagtta ttgactggta tcagcacctg cagatcaaca agaagatgac caacgaggta     960

gccatcttac agcacttgcc tgagcggctg cgggcagaag tggctgtgtc tgtgcacctg    1020

tccactctga gccgggtgca gatctttcag aactgtgagg ccagcctgct ggaggagctg    1080

gtgctgaagc tgcagcccca gacctactca ccaggtgaat atgtatgccg caaaggagac    1140

attggccaag agatgtacat catccgagag ggtcaactgg ccgtggtggc agatgatggt    1200

atcacacagt atgctgtgct cggtgcaggg ctctactttg gggagatcag catcatcaac    1260

atcaaaggga acatgtctgg gaaccgccgc acagccaaca tcaagagcct aggttattca    1320

gacctattct gcctgagcaa ggaggacctg cgggaggtgc tgagcgagta tccacaagca    1380

cagaccatca tggaggagaa aggacgtgag atcctgctga aaatgaacaa gttggacgtg    1440

aatgctgagg cagctgagat cgccctgcag gaggccacag agtcccggct acgaggccta    1500

gaccagcagc tggatgatct acagaccaag tttgctcgcc tcctggctga gctggagtcc    1560

agcgcactta agattgctta ccgcattgaa cggctggagt ggcagactcg agagtggcca    1620

atgcccgagg acctggctga ggctgatgac gagggtgagc ctgaggaggg aacttccaaa    1680

gatgaagagg gcagggccag ccaggaggga cccccaggtc cagagtga                 1728


<210> 20
<211> 575
<212> PRT
<213> Homo sapiens


<400> 20
Met Ser Gln Asp Thr Lys Val Lys Thr Thr Glu Ser Ser Pro Pro Ala 
1               5                   10                  15      
Pro Ser Lys Ala Arg Lys Leu Leu Pro Val Leu Asp Pro Ser Gly Asp 
            20                  25                  30          
Tyr Tyr Tyr Trp Trp Leu Asn Thr Met Val Phe Pro Val Met Tyr Asn 
        35                  40                  45              
Leu Ile Ile Leu Val Cys Arg Ala Cys Phe Pro Asp Leu Gln His Gly 
    50                  55                  60                  
Tyr Leu Val Ala Trp Leu Val Leu Asp Tyr Thr Ser Asp Leu Leu Tyr 
65                  70                  75                  80  
Leu Leu Asp Met Val Val Arg Phe His Thr Gly Phe Leu Glu Gln Gly 
                85                  90                  95      
Ile Leu Val Val Asp Lys Gly Arg Ile Ser Ser Arg Tyr Val Arg Thr 
            100                 105                 110         
Trp Ser Phe Phe Leu Asp Leu Ala Ser Leu Met Pro Thr Asp Val Val 
        115                 120                 125             
Tyr Val Arg Leu Gly Pro His Thr Pro Thr Leu Arg Leu Asn Arg Phe 
    130                 135                 140                 
Leu Arg Ala Pro Arg Leu Phe Glu Ala Phe Asp Arg Thr Glu Thr Arg 
145                 150                 155                 160 
Thr Ala Tyr Pro Asn Ala Phe Arg Ile Ala Lys Leu Met Leu Tyr Ile 
                165                 170                 175     
Phe Val Val Ile His Trp Asn Ser Cys Leu Tyr Phe Ala Leu Ser Arg 
            180                 185                 190         
Tyr Leu Gly Phe Gly Arg Asp Ala Trp Val Tyr Pro Asp Pro Ala Gln 
        195                 200                 205             
Pro Gly Phe Glu Arg Leu Arg Arg Gln Tyr Leu Tyr Ser Phe Tyr Phe 
    210                 215                 220                 
Ser Thr Leu Ile Leu Thr Thr Val Gly Asp Thr Pro Pro Pro Ala Arg 
225                 230                 235                 240 
Glu Glu Glu Tyr Leu Phe Met Val Gly Asp Phe Leu Leu Ala Val Met 
                245                 250                 255     
Gly Phe Ala Thr Ile Met Gly Ser Met Ser Ser Val Ile Tyr Asn Met 
            260                 265                 270         
Asn Thr Ala Asp Ala Ala Phe Tyr Pro Asp His Ala Leu Val Lys Lys 
        275                 280                 285             
Tyr Met Lys Leu Gln His Val Asn Arg Lys Leu Glu Arg Arg Val Ile 
    290                 295                 300                 
Asp Trp Tyr Gln His Leu Gln Ile Asn Lys Lys Met Thr Asn Glu Val 
305                 310                 315                 320 
Ala Ile Leu Gln His Leu Pro Glu Arg Leu Arg Ala Glu Val Ala Val 
                325                 330                 335     
Ser Val His Leu Ser Thr Leu Ser Arg Val Gln Ile Phe Gln Asn Cys 
            340                 345                 350         
Glu Ala Ser Leu Leu Glu Glu Leu Val Leu Lys Leu Gln Pro Gln Thr 
        355                 360                 365             
Tyr Ser Pro Gly Glu Tyr Val Cys Arg Lys Gly Asp Ile Gly Gln Glu 
    370                 375                 380                 
Met Tyr Ile Ile Arg Glu Gly Gln Leu Ala Val Val Ala Asp Asp Gly 
385                 390                 395                 400 
Ile Thr Gln Tyr Ala Val Leu Gly Ala Gly Leu Tyr Phe Gly Glu Ile 
                405                 410                 415     
Ser Ile Ile Asn Ile Lys Gly Asn Met Ser Gly Asn Arg Arg Thr Ala 
            420                 425                 430         
Asn Ile Lys Ser Leu Gly Tyr Ser Asp Leu Phe Cys Leu Ser Lys Glu 
        435                 440                 445             
Asp Leu Arg Glu Val Leu Ser Glu Tyr Pro Gln Ala Gln Thr Ile Met 
    450                 455                 460                 
Glu Glu Lys Gly Arg Glu Ile Leu Leu Lys Met Asn Lys Leu Asp Val 
465                 470                 475                 480 
Asn Ala Glu Ala Ala Glu Ile Ala Leu Gln Glu Ala Thr Glu Ser Arg 
                485                 490                 495     
Leu Arg Gly Leu Asp Gln Gln Leu Asp Asp Leu Gln Thr Lys Phe Ala 
            500                 505                 510         
Arg Leu Leu Ala Glu Leu Glu Ser Ser Ala Leu Lys Ile Ala Tyr Arg 
        515                 520                 525             
Ile Glu Arg Leu Glu Trp Gln Thr Arg Glu Trp Pro Met Pro Glu Asp 
    530                 535                 540                 
Leu Ala Glu Ala Asp Asp Glu Gly Glu Pro Glu Glu Gly Thr Ser Lys 
545                 550                 555                 560 
Asp Glu Glu Gly Arg Ala Ser Gln Glu Gly Pro Pro Gly Pro Glu 
                565                 570                 575 

<210> 21
<211> 3756
<212> DNA
<213> Homo sapiens


<400> 21
atgttgggct gggtccagag ggtgctgcct cagcccccag ggacccctcg gaagaccaag       60

atgcaggagg aagaggaagt ggaaccagag ccagagatgg aggcggaggt ggaaccagaa      120

ccgaatcctg aggaggccga gacagagtcc gagtccatgc cccccgaaga gtcattcaag      180

gaggaggaag tggctgtggc agacccaagc cctcaggaga ccaaggaggc tgcccttact      240

tccaccatat ccctccgggc ccagggcgct gagatttctg aaatgaatag tcccagccgc      300

agggtactga cctggctcat gaagggcgta gagaaggtga tcccgcagcc tgttcacagc      360

atcacggagg acccggctca gatcctgggg catggcagca ctggggacac agggtgcaca      420

gatgaaccca atgaggccct tgaggcccaa gacactaggc ctgggctgcg gctgcttctg      480

tggctggagc agaatctgga aagagtgctt cctcagcccc ccaaatcctc tgaggtctgg      540

agagatgagc ctgcagttgc tacaggtgct gcctcagacc cagcgcctcc aggacgcccc      600

caggaaatgg ggcccaagct gcaggcccgg gagaccccct ccctgcccac acccatcccc      660

ctgcagccca aggaggaacc caaggaggca ccagctccag agccccagcc cggctcccag      720

gcccagacct cctccctgcc accaaccagg gaccctgcca ggctggtggc atgggtcctg      780

cacaggctgg agatggcctt gccgcagcca gtgctacatg ggaaaatagg ggaacaggag      840

cctgactccc ctgggatatg tgatgtgcag accatcagca tccttcctgg aggacaagtg      900

gagcctgacc ttgtcctaga ggaggttgaa ccgccctggg aggatgccca ccaggatgtc      960

agtaccagcc cacagggtac agaggtggtt ccagcttatg aagaagagaa caaagctgtg     1020

gagaagatgc ccagagagct gtcccggatt gaagaggaga aagaagatga ggaggaggaa     1080

gaggaagagg aggaggagga ggaagaggag gaggtgactg aggtgctgct ggatagctgt     1140

gtggtgtcgc aggtgggcgt gggccagagt gaagaagacg ggacccggcc ccagagcact     1200

tcagatcaga agctgtggga ggaagttggg gaggaggcca agaaggaggc tgaagagaag     1260

gccaaggagg aggccgagga ggtggctgaa gaggaggctg aaaaggagcc ccaggactgg     1320

gcggagacca aggaggagcc tgaggctgag gccgaggctg ccagttcagg agtgcctgcc     1380

acgaaacagc acccagaagt gcaggtggaa gatactgatg ctgatagctg ccccctcatg     1440

gcagaagaga atccaccctc aaccgtgttg ccgccaccgt ctcctgccaa atcagacacc     1500

cttatagtcc caagctcagc ctcggggaca cacaggaaga agctgccctc tgaggatgat     1560

gaggctgaag agctcaaggc gttgtcacca gcagagtccc cagtggttgc ctggtctgac     1620

cccaccaccc cgaaggacac tgatggccag gaccgtgcgg cctccacggc cagcacaaat     1680

agcgccatca tcaacgaccg gctccaggag ctggtgaagc tcttcaagga gcggacagag     1740

aaagtgaagg agaaactcat tgaccctgac gtcacctctg atgaggagag ccccaagccc     1800

tccccagcca agaaagcccc agagccagct ccagacacaa agcccgctga agccgagcca     1860

gtggaagagg agcactattg cgacatgctc tgctgcaagt tcaaacaccg cccctggaag     1920

aagtaccagt ttccccagag cattgacccg ctgaccaacc tgatgtatgt cctatggctg     1980

ttcttcgtgg tgatggcctg gaattggaac tgttggctga ttcccgtgcg ctgggccttc     2040

ccctaccaga ccccggacaa catccaccac tggctgctga tggattacct atgcgacctc     2100

atctacttcc tggacatcac cgtgttccag acacgcctgc agtttgtcag aggcggggac     2160

atcattacgg acaaaaagga catgcgaaat aactacctga agtctcgccg cttcaagatg     2220

gacctgctca gcctcctgcc cttggatttt ctctatttga aagtcggtgt gaaccccctc     2280

ctccgcctgc cccgctgttt aaagtacatg gccttcttcg agtttaacag ccgcctggaa     2340

tccatcctca gcaaagccta cgtgtacagg gtcatcagga ccacagccta ccttctctac     2400

agcctgcatt tgaattcctg tctttattac tgggcatcgg cctatcaggg cctcggctcc     2460

actcactggg tttacgatgg cgtgggaaac agttatattc gctgttacta ctttgctgtg     2520

aagaccctca tcaccatcgg ggggctgcct gaccccaaga cactctttga aattgtcttc     2580

cagctgctga attatttcac gggcgtcttt gctttctctg tgatgatcgg acagatgaga     2640

gatgtggtag gggccgccac cgccggacag acctactacc gcagctgcat ggacagcacg     2700

gtgaagtaca tgaatttcta caagatcccc aagtccgtgc agaaccgcgt caagacctgg     2760

tacgagtaca cctggcactc gcaaggcatg ctggatgagt cagagctgat ggtgcagctt     2820

ccagacaaga tgcggctgga cctcgccatc gacgtgaact acaacatcgt tagcaaagtc     2880

gcactctttc agggctgtga ccggcagatg atctttgaca tgctgaagag gcttcgctct     2940

gttgtctacc tgcccaacga ctatgtgtgc aagaaggggg agatcggccg tgagatgtac     3000

atcatccagg cagggcaagt gcaggtcttg ggcggccctg atgggaaatc tgtgctggtg     3060

acgctgaaag ctggatctgt gtttggagaa ataagcttgc tggctgttgg gggcgggaac     3120

cggcgcacgg ccaacgtggt ggcgcacggg tttaccaacc tcttcatcct ggataagaag     3180

gacctgaatg agattttggt gcattatcct gagtctcaga agttactccg gaagaaagcc     3240

aggcgcatgc tgagaagcaa caataagccc aaggaggaga agagcgtgct gatccttcca     3300

ccccgggcgg gcaccccaaa gctcttcaac gctgccctcg ctatgacagg aaagatgggt     3360

ggcaaggggg caaaaggcgg caaacttgct cacctccggg cccggctcaa agaactggcc     3420

gcgctggagg cggctgcaaa gcagcaagag ttggtggaac aggccaagag ctcgcaagac     3480

gtcaagggag aggaaggctc cgccgcccca gaccagcaca cgcacccaaa ggaggccgcc     3540

accgacccac ccgcgccccg gacgcccccc gagcccccgg ggtctccacc gagctctcca     3600

ccgcctgcct cccttgggag gccggaggga gaggaggagg ggccggccga gcccgaagag     3660

cactcggtga ggatctgcat gagcccgggc ccggagccgg gagagcagat cctgtcggtg     3720

aagatgccgg aggaaaggga ggagaaggcg gagtaa                               3756


<210> 22
<211> 1251
<212> PRT
<213> Homo sapiens


<400> 22
Met Leu Gly Trp Val Gln Arg Val Leu Pro Gln Pro Pro Gly Thr Pro 
1               5                   10                  15      
Arg Lys Thr Lys Met Gln Glu Glu Glu Glu Val Glu Pro Glu Pro Glu 
            20                  25                  30          
Met Glu Ala Glu Val Glu Pro Glu Pro Asn Pro Glu Glu Ala Glu Thr 
        35                  40                  45              
Glu Ser Glu Ser Met Pro Pro Glu Glu Ser Phe Lys Glu Glu Glu Val 
    50                  55                  60                  
Ala Val Ala Asp Pro Ser Pro Gln Glu Thr Lys Glu Ala Ala Leu Thr 
65                  70                  75                  80  
Ser Thr Ile Ser Leu Arg Ala Gln Gly Ala Glu Ile Ser Glu Met Asn 
                85                  90                  95      
Ser Pro Ser Arg Arg Val Leu Thr Trp Leu Met Lys Gly Val Glu Lys 
            100                 105                 110         
Val Ile Pro Gln Pro Val His Ser Ile Thr Glu Asp Pro Ala Gln Ile 
        115                 120                 125             
Leu Gly His Gly Ser Thr Gly Asp Thr Gly Cys Thr Asp Glu Pro Asn 
    130                 135                 140                 
Glu Ala Leu Glu Ala Gln Asp Thr Arg Pro Gly Leu Arg Leu Leu Leu 
145                 150                 155                 160 
Trp Leu Glu Gln Asn Leu Glu Arg Val Leu Pro Gln Pro Pro Lys Ser 
                165                 170                 175     
Ser Glu Val Trp Arg Asp Glu Pro Ala Val Ala Thr Gly Ala Ala Ser 
            180                 185                 190         
Asp Pro Ala Pro Pro Gly Arg Pro Gln Glu Met Gly Pro Lys Leu Gln 
        195                 200                 205             
Ala Arg Glu Thr Pro Ser Leu Pro Thr Pro Ile Pro Leu Gln Pro Lys 
    210                 215                 220                 
Glu Glu Pro Lys Glu Ala Pro Ala Pro Glu Pro Gln Pro Gly Ser Gln 
225                 230                 235                 240 
Ala Gln Thr Ser Ser Leu Pro Pro Thr Arg Asp Pro Ala Arg Leu Val 
                245                 250                 255     
Ala Trp Val Leu His Arg Leu Glu Met Ala Leu Pro Gln Pro Val Leu 
            260                 265                 270         
His Gly Lys Ile Gly Glu Gln Glu Pro Asp Ser Pro Gly Ile Cys Asp 
        275                 280                 285             
Val Gln Thr Ile Ser Ile Leu Pro Gly Gly Gln Val Glu Pro Asp Leu 
    290                 295                 300                 
Val Leu Glu Glu Val Glu Pro Pro Trp Glu Asp Ala His Gln Asp Val 
305                 310                 315                 320 
Ser Thr Ser Pro Gln Gly Thr Glu Val Val Pro Ala Tyr Glu Glu Glu 
                325                 330                 335     
Asn Lys Ala Val Glu Lys Met Pro Arg Glu Leu Ser Arg Ile Glu Glu 
            340                 345                 350         
Glu Lys Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
        355                 360                 365             
Glu Glu Glu Val Thr Glu Val Leu Leu Asp Ser Cys Val Val Ser Gln 
    370                 375                 380                 
Val Gly Val Gly Gln Ser Glu Glu Asp Gly Thr Arg Pro Gln Ser Thr 
385                 390                 395                 400 
Ser Asp Gln Lys Leu Trp Glu Glu Val Gly Glu Glu Ala Lys Lys Glu 
                405                 410                 415     
Ala Glu Glu Lys Ala Lys Glu Glu Ala Glu Glu Val Ala Glu Glu Glu 
            420                 425                 430         
Ala Glu Lys Glu Pro Gln Asp Trp Ala Glu Thr Lys Glu Glu Pro Glu 
        435                 440                 445             
Ala Glu Ala Glu Ala Ala Ser Ser Gly Val Pro Ala Thr Lys Gln His 
    450                 455                 460                 
Pro Glu Val Gln Val Glu Asp Thr Asp Ala Asp Ser Cys Pro Leu Met 
465                 470                 475                 480 
Ala Glu Glu Asn Pro Pro Ser Thr Val Leu Pro Pro Pro Ser Pro Ala 
                485                 490                 495     
Lys Ser Asp Thr Leu Ile Val Pro Ser Ser Ala Ser Gly Thr His Arg 
            500                 505                 510         
Lys Lys Leu Pro Ser Glu Asp Asp Glu Ala Glu Glu Leu Lys Ala Leu 
        515                 520                 525             
Ser Pro Ala Glu Ser Pro Val Val Ala Trp Ser Asp Pro Thr Thr Pro 
    530                 535                 540                 
Lys Asp Thr Asp Gly Gln Asp Arg Ala Ala Ser Thr Ala Ser Thr Asn 
545                 550                 555                 560 
Ser Ala Ile Ile Asn Asp Arg Leu Gln Glu Leu Val Lys Leu Phe Lys 
                565                 570                 575     
Glu Arg Thr Glu Lys Val Lys Glu Lys Leu Ile Asp Pro Asp Val Thr 
            580                 585                 590         
Ser Asp Glu Glu Ser Pro Lys Pro Ser Pro Ala Lys Lys Ala Pro Glu 
        595                 600                 605             
Pro Ala Pro Asp Thr Lys Pro Ala Glu Ala Glu Pro Val Glu Glu Glu 
    610                 615                 620                 
His Tyr Cys Asp Met Leu Cys Cys Lys Phe Lys His Arg Pro Trp Lys 
625                 630                 635                 640 
Lys Tyr Gln Phe Pro Gln Ser Ile Asp Pro Leu Thr Asn Leu Met Tyr 
                645                 650                 655     
Val Leu Trp Leu Phe Phe Val Val Met Ala Trp Asn Trp Asn Cys Trp 
            660                 665                 670         
Leu Ile Pro Val Arg Trp Ala Phe Pro Tyr Gln Thr Pro Asp Asn Ile 
        675                 680                 685             
His His Trp Leu Leu Met Asp Tyr Leu Cys Asp Leu Ile Tyr Phe Leu 
    690                 695                 700                 
Asp Ile Thr Val Phe Gln Thr Arg Leu Gln Phe Val Arg Gly Gly Asp 
705                 710                 715                 720 
Ile Ile Thr Asp Lys Lys Asp Met Arg Asn Asn Tyr Leu Lys Ser Arg 
                725                 730                 735     
Arg Phe Lys Met Asp Leu Leu Ser Leu Leu Pro Leu Asp Phe Leu Tyr 
            740                 745                 750         
Leu Lys Val Gly Val Asn Pro Leu Leu Arg Leu Pro Arg Cys Leu Lys 
        755                 760                 765             
Tyr Met Ala Phe Phe Glu Phe Asn Ser Arg Leu Glu Ser Ile Leu Ser 
    770                 775                 780                 
Lys Ala Tyr Val Tyr Arg Val Ile Arg Thr Thr Ala Tyr Leu Leu Tyr 
785                 790                 795                 800 
Ser Leu His Leu Asn Ser Cys Leu Tyr Tyr Trp Ala Ser Ala Tyr Gln 
                805                 810                 815     
Gly Leu Gly Ser Thr His Trp Val Tyr Asp Gly Val Gly Asn Ser Tyr 
            820                 825                 830         
Ile Arg Cys Tyr Tyr Phe Ala Val Lys Thr Leu Ile Thr Ile Gly Gly 
        835                 840                 845             
Leu Pro Asp Pro Lys Thr Leu Phe Glu Ile Val Phe Gln Leu Leu Asn 
    850                 855                 860                 
Tyr Phe Thr Gly Val Phe Ala Phe Ser Val Met Ile Gly Gln Met Arg 
865                 870                 875                 880 
Asp Val Val Gly Ala Ala Thr Ala Gly Gln Thr Tyr Tyr Arg Ser Cys 
                885                 890                 895     
Met Asp Ser Thr Val Lys Tyr Met Asn Phe Tyr Lys Ile Pro Lys Ser 
            900                 905                 910         
Val Gln Asn Arg Val Lys Thr Trp Tyr Glu Tyr Thr Trp His Ser Gln 
        915                 920                 925             
Gly Met Leu Asp Glu Ser Glu Leu Met Val Gln Leu Pro Asp Lys Met 
    930                 935                 940                 
Arg Leu Asp Leu Ala Ile Asp Val Asn Tyr Asn Ile Val Ser Lys Val 
945                 950                 955                 960 
Ala Leu Phe Gln Gly Cys Asp Arg Gln Met Ile Phe Asp Met Leu Lys 
                965                 970                 975     
Arg Leu Arg Ser Val Val Tyr Leu Pro Asn Asp Tyr Val Cys Lys Lys 
            980                 985                 990         
Gly Glu Ile Gly Arg Glu Met Tyr Ile Ile Gln Ala Gly Gln Val Gln 
        995                 1000                1005            
Val Leu Gly Gly Pro Asp Gly Lys Ser Val Leu Val Thr Leu Lys Ala 
    1010                1015                1020                
Gly Ser Val Phe Gly Glu Ile Ser Leu Leu Ala Val Gly Gly Gly Asn 
1025                1030                1035                1040
Arg Arg Thr Ala Asn Val Val Ala His Gly Phe Thr Asn Leu Phe Ile 
                1045                1050                1055    
Leu Asp Lys Lys Asp Leu Asn Glu Ile Leu Val His Tyr Pro Glu Ser 
            1060                1065                1070        
Gln Lys Leu Leu Arg Lys Lys Ala Arg Arg Met Leu Arg Ser Asn Asn 
        1075                1080                1085            
Lys Pro Lys Glu Glu Lys Ser Val Leu Ile Leu Pro Pro Arg Ala Gly 
    1090                1095                1100                
Thr Pro Lys Leu Phe Asn Ala Ala Leu Ala Met Thr Gly Lys Met Gly 
1105                1110                1115                1120
Gly Lys Gly Ala Lys Gly Gly Lys Leu Ala His Leu Arg Ala Arg Leu 
                1125                1130                1135    
Lys Glu Leu Ala Ala Leu Glu Ala Ala Ala Lys Gln Gln Glu Leu Val 
            1140                1145                1150        
Glu Gln Ala Lys Ser Ser Gln Asp Val Lys Gly Glu Glu Gly Ser Ala 
        1155                1160                1165            
Ala Pro Asp Gln His Thr His Pro Lys Glu Ala Ala Thr Asp Pro Pro 
    1170                1175                1180                
Ala Pro Arg Thr Pro Pro Glu Pro Pro Gly Ser Pro Pro Ser Ser Pro 
1185                1190                1195                1200
Pro Pro Ala Ser Leu Gly Arg Pro Glu Gly Glu Glu Glu Gly Pro Ala 
                1205                1210                1215    
Glu Pro Glu Glu His Ser Val Arg Ile Cys Met Ser Pro Gly Pro Glu 
            1220                1225                1230        
Pro Gly Glu Gln Ile Leu Ser Val Lys Met Pro Glu Glu Arg Glu Glu 
        1235                1240                1245            
Lys Ala Glu 
    1250    

<210> 23
<211> 2430
<212> DNA
<213> Homo sapiens


<400> 23
atgtttaaat cgctgacaaa agtcaacaag gtgaagccta taggagagaa caatgagaat      60

gaacaaagtt ctcgtcggaa tgaagaaggc tctcacccaa gtaatcagtc tcagcaaacc     120

acagcacagg aagaaaacaa aggtgaagag aaatctctca aaaccaagtc aactccagtc     180

acgtctgaag agccacacac caacatacaa gacaaactct ccaagaaaaa ttcctctgga     240

gatctgacca caaaccctga ccctcaaaat gcagcagaac caactggaac agtgccagag     300

cagaaggaaa tggaccccgg gaaagaaggt ccaaacagcc cacaaaacaa accgcctgca     360

gctcctgtta taaatgagta tgccgatgcc cagctacaca acctggtgaa aagaatgcgt     420

caaagaacag ccctctacaa gaaaaagttg gtagagggag atctctcctc acccgaagcc     480

agcccacaaa ctgcaaagcc cacggctgta ccaccagtaa aagaaagcga tgataagcca     540

acagaacatt actacaggct gttgtggttc aaagtcaaaa agatgccttt aacagagtac     600

ttaaagcgaa ttaaacttcc aaacagcata gattcataca cagatcgact ctatctcctg     660

tggctcttgc ttgtcactct tgcctataac tggaactgct gttttatacc actgcgcctc     720

gtcttcccat atcaaaccgc agacaacata cactactggc ttattgcgga catcatatgt     780

gatatcatct acctttatga tatgctattt atccagccca gactccagtt tgtaagagga     840

ggagacataa tagtggattc aaatgagcta aggaaacact acaggacttc tacaaaattt     900

cagttggatg tcgcatcaat aataccattt gatatttgct acctcttctt tgggtttaat     960

ccaatgttta gagcaaatag gatgttaaag tacacttcat tttttgaatt taatcatcac    1020

ctagagtcta taatggacaa agcatatatc tacagagtta ttcgaacaac tggatacttg    1080

ctgtttattc tgcacattaa tgcctgtgtt tattactggg cttcaaacta tgaaggaatt    1140

ggcactacta gatgggtgta tgatggggaa ggaaacgagt atctgagatg ttattattgg    1200

gcagttcgaa ctttaattac cattggtggc cttccagaac cacaaacttt atttgaaatt    1260

gtttttcaac tcttgaattt tttttctgga gtttttgtgt tctccagttt aattggtcag    1320

atgagagatg tgattggagc agctacagcc aatcagaact acttccgcgc ctgcatggat    1380

gacaccattg cctacatgaa caattactcc attcctaaac ttgtgcaaaa gcgagttcgg    1440

acttggtatg aatatacatg ggactctcaa agaatgctag atgagtctga tttgcttaag    1500

accctaccaa ctacggtcca gttagccctc gccattgatg tgaacttcag catcatcagc    1560

aaagtcgact tgttcaaggg ttgtgataca cagatgattt atgacatgtt gctaagattg    1620

aaatccgttc tctatttgcc tggtgacttt gtctgcaaaa agggagaaat tggcaaggaa    1680

atgtatatca tcaagcatgg agaagtccaa gttcttggag gccctgatgg tactaaagtt    1740

ctggttactc tgaaagctgg gtcggtgttt ggagaaatca gccttctagc agcaggagga    1800

ggaaaccgtc gaactgccaa tgtggtggcc cacgggtttg ccaatctttt aactctagac    1860

aaaaagaccc tccaagaaat tctagtgcat tatccagatt ctgaaaggat cctcatgaag    1920

aaagccagag tgcttttaaa gcagaaggct aagaccgcag aagcaacccc tccaagaaaa    1980

gatcttgccc tcctcttccc accgaaagaa gagacaccca aactgtttaa aactctccta    2040

ggaggcacag gaaaagcaag tcttgcaaga ctactcaaat tgaagcgaga gcaagcagct    2100

cagaagaaag aaaattctga aggaggagag gaagaaggaa aagaaaatga agataaacaa    2160

aaagaaaatg aagataaaca aaaagaaaat gaagataaag gaaaagaaaa tgaagataaa    2220

gataaaggaa gagagccaga agagaagcca ctggacagac ctgaatgtac agcaagtcct    2280

attgcagtgg aggaagaacc ccactcagtt agaaggacag ttttacccag agggacttct    2340

cgtcaatcac tcattatcag catggctcct tctgctgagg gcggagaaga ggttcttact    2400

attgaagtca aagaaaaggc taagcaataa                                     2430


<210> 24
<211> 809
<212> PRT
<213> Homo sapiens


<400> 24
Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      
Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          
Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              
Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  
Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  
Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      
Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         
Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             
Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 
Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 
Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     
Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         
Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             
Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 
Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 
Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     
Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         
Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             
Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 
Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 
Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     
Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         
Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             
Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 
Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 
Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     
Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         
Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             
Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 
Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 
Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     
Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         
Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             
Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 
Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 
Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     
Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         
Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             
Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 
Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 
Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     
Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         
Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             
Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 
Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 
Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     
Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         
Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             
Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 
Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 
Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 

<210> 25
<211> 5568
<212> DNA
<213> Homo sapiens


<400> 25
atggctgcgt cggagctcta cacaaagttt gccagggttt ggatacctga tccagaggaa       60

gtctggaagt cagcagagct gctcaaagat tataagccag gagataaagt cctcctgctt      120

cacctcgagg aaggaaagga tttggaatac catctagatc caaagaccaa ggagctgcct      180

cacttacgaa atcctgacat acttgttggt gaaaatgacc tcacagccct cagctatctt      240

catgagcctg ctgtgctcca taatctcaga gtccgcttta ttgattccaa acttatttat      300

acgtattgtg gtatagtcct agtagctata aatccctatg aacagctgcc tatttatgga      360

gaagatatta ttaatgcata cagtggtcag aacatgggtg atatggatcc acatatcttt      420

gcagtagctg aagaagctta caagcaaatg gccagagatg aacgaaatca gtccatcatc      480

gtaagtggag agtctggggc aggaaaaaca gtctcagcta agtatgccat gcgatacttt      540

gcaactgtga gtggttctgc cagtgaggcc aatgtggagg aaaaggtctt ggcctccaac      600

cccatcatgg agtccattgg aaatgctaaa acaaccagga atgataatag cagccgtttt      660

gggaagtata ttgagattgg ttttgataag agatatcgaa tcattggtgc caatatgaga      720

acttatcttt tagagaaatc cagagtggta ttccaggcag aagaggagag aaactatcat      780

atcttctatc agctttgtgc ctcagcaaag ttacctgaat ttaaaatgct acgattagga      840

aatgcagata actttaatta cacaaaacaa ggaggcagtc ctgtgattga aggagtggat      900

gatgcaaagg agatggcaca tactaggcag gcctgcactt tgctaggaat tagtgaatct      960

catcaaatgg gaattttccg aatacttgct ggcatccttc acttaggcaa tgttggattt     1020

acatcccgag atgcagacag ctgcacaata cctcccaagc atgaacctct ctgcatcttc     1080

tgtgaactca tgggtgtgga ctatgaggag atgtgtcact ggctctgcca tcggaaactg     1140

gctactgcca cagagacata catcaagccc atctccaagc tgcaggccac gaatgcccgc     1200

gatgctttgg ccaagcacat ctatgccaag ctctttaact ggattgtaga taatgtcaat     1260

caggctctcc attctgctgt caaacagcac tcttttattg gtgtgctaga catttacgga     1320

tttgaaacat ttgagataaa tagttttgaa cagttttgca taaattatgc aaatgaaaaa     1380

ctacagcaac aattcaatat gcatgtcttc aaattggagc aagaagaata tatgaaggaa     1440

caaattccat ggacactcat agatttttat gataatcagc cttgtattaa tcttatagaa     1500

tcaaaactag gcattctaga tttactggat gaggaatgca agatgcctaa aggcacagat     1560

gacacctggg cccaaaaatt gtacaacaca catttgaaca aatgtgcact ctttgaaaag     1620

cctcgtctat caaacaaagc tttcatcatc caacattttg ctgacaaagt ggaataccag     1680

tgtgaaggat ttctcgaaaa gaataaagac accgtttttg aagaacaaat taaagttctt     1740

aaatcaagca agtttaagat gctaccagaa ctatttcaag atgatgagaa ggccatcagt     1800

ccaacttcag ccacctcctc agggcgcaca cccctcacac gaactcctgc aaagcccacc     1860

aaaggcagac caggccaaat ggccaaagag cacaagaaaa cagtggggca tcagttcaga     1920

aactccctgc acctgcttat ggagacactc aatgccacta cccctcacta tgtgcgctgt     1980

atcaagccta atgacttcaa gttcccattc acgtttgatg agaagagggc agtgcagcag     2040

ctgagagcat gtggtgtcct ggaaaccatc cgaatcagtg cggccggttt cccctcacgg     2100

tggacttacc aagaattttt cagccgctac cgtgtcctaa tgaagcagaa agatgtgctg     2160

agtgacagaa agcaaacatg caagaatgtg ttagagaaac tgatactgga caaggacaaa     2220

taccagtttg gtaagacaaa gatctttttc cgtgccggtc aagtggccta tctagaaaaa     2280

ttgagagctg acaaactgag agctgcctgc atccggatcc agaagaccat ccgagggtgg     2340

ctgctgagaa agaagtacct acgcatgcgg aaggcagcca tcaccatgca gagatacgtg     2400

cggggctacc aggcccgatg ctatgctaag tttctgcgca gaaccaaggc agcaaccatc     2460

attcaaaagt actggcgcat gtatgtggtc cgcaggaggt acaagattag acgagctgcc     2520

actatcgttc ttcagtctta cttgcgaggc ttcttggcca gaaataggta tcgcaagata     2580

ctccgtgagc acaaagcagt catcattcag aagcgagtcc ggggctggct ggcccgcaca     2640

cactacaaga ggagcatgca tgccatcatc taccttcagt gctgcttcag gcggatgatg     2700

gccaagcgtg agctaaagaa gctcaaaatc gaggctcgct cagtggagcg ctataagaag     2760

ctgcacatcg gcatggagaa caagatcatg cagctgcagc gcaaagttga tgagcagaac     2820

aaagactaca aatgccttgt ggagaaacta accaatctgg aaggaatata caactctgag     2880

actgagaaac tacgaagtga cttagaacgt cttcaactaa gtgaagagga agcgaaagtt     2940

gccactgggc gggtccttag tctgcaggaa gaaattgcca agctccggaa agacctggag     3000

caaactcgtt cagagaaaaa atgcattgag gaacatgcag atcgatacaa acaagaaaca     3060

gagcagctgg tatcaaatct gaaggaagaa aatactttgc tgaagcaaga aaaagaagcc     3120

ctcaatcacc gcatcgtgca gcaggctaag gagatgacag aaactatgga gaagaagtta     3180

gtagaagaaa cgaaacaact ggaactcgac cttaatgatg aaaggctgag atatcagaac     3240

cttctgaatg agttcagtcg cctggaagaa agatatgatg acctcaagga agagatgacc     3300

cttatggtgc atgtgcctaa gcctggacac aagagaacag actccaccca cagcagcaac     3360

gagtctgaat atatctttag ctctgaaatt gcagaaatgg aagacattcc atcaaggaca     3420

gaggaaccaa gtgagaagaa ggtacctctg gacatgtcat tgttccttaa gctccagaag     3480

cgggtcacag agctggagca ggagaagcag gtgatgcagg atgagctgga ccgcaaggag     3540

gagcaggtgc tccgcagcaa ggccaaggaa gaagaaagac cacaaattag aggtgcagaa     3600

ctggaatatg agtcactcaa gcgtcaagaa ctagaatcag aaaacaaaaa actgaagaat     3660

gagctaaatg agttgcgcaa ggccctcagt gagaaaagtg ccccagaggt gaccgcccca     3720

ggtgcacctg cctaccgtgt cctcatggag cagctgacct ctgtgagcga ggagcttgat     3780

gtccgcaagg aggaagtcct catcttaagg tctcaactgg tgagccagaa agaggccatc     3840

caacccaagg atgacaagaa tacaatgaca gattccacaa tacttttgga agatgtacaa     3900

aaaatgaaag ataaaggtga aatagcacaa gcatacattg gtttgaaaga aacaaataga     3960

tcatctgctc tggattacca tgagttgaat gaggatggag agctgtggct ggtttatgaa     4020

gggttaaaac aagccaacag gctcctggaa tcccagctgc agtcacagaa gaggagccat     4080

gagaatgagg ccgaggccct ccgtggggag atccagagcc tgaaggagga gaacaaccga     4140

cagcagcagc tgctggccca gaacctgcag ctgcccccag aggcccgcat tgaggccagc     4200

ctgcagcacg agatcacccg gctgaccaac gaaaacttgg atttgatgga acaacttgaa     4260

aaacaggata agacggtccg taaactgaaa aaacaactga aagtatttgc caaaaaaatt     4320

ggcgaactag aagtgggcca gatggagaac atatccccag gacagatcat tgatgaaccc     4380

atccgaccag tcaacattcc caggaaagaa aaggatttcc aagggatgct ggaatacaag     4440

aaggaggatg agcaaaaact tgttaagaac ctgattctgg aactgaagcc acgtggtgta     4500

gcagtcaatt tgattccagg attaccggca tatatcctgt tcatgtgtgt tcgacatgct     4560

gactacctga atgatgatca gaaagtaagg tcgttgctaa catcaacaat taacagcatc     4620

aaaaaagtat tgaagaaaag aggtgatgat tttgaaaccg tctccttctg gctctctaac     4680

acatgccgat ttttgcactg cttgaaacag tacagtggag aagagggctt tatgaagcac     4740

aacacatctc gccagaatga acactgcctc accaattttg acctggctga gtatcggcag     4800

gtgctgagtg acttggccat tcagatctac cagcagctcg tgcgggtgtt agagaacatc     4860

cttcagccaa tgattgtctc aggcatgctg gaacatgaaa cgattcaggg cgtgtctggg     4920

gtgaagccca cagggttgag aaagcgaacc tccagtatcg ccgatgaggg cacctacaca     4980

ctggactcca tcctccggca gctcaactcc ttccactcgg tcatgtgtca gcatggcatg     5040

gaccctgaac tgatcaagca ggtggtcaag cagatgttct acatcatagg ggccatcacc     5100

ctgaacaacc ttctcctgcg gaaggacatg tgctcctgga gtaaaggcat gcagatcagg     5160

tacaatgtca gtcaactgga agaatggctg cgtgacaaga atctgatgaa tagtggggct     5220

aaagaaaccc tggaacctct cattcaggct gctcaacttt tgcaagtgaa aaagaaaaca     5280

gatgatgatg cagaagccat ttgttctatg tgcaatgctt taactactgc ccagattgtg     5340

aaagtgttga atttgtatac tccagttaat gagtttgaag aaagagtctc tgtgtcgttc     5400

attcgtacta tacagatgcg tttacgagac aggaaagact ctccccagct gctcatggat     5460

gctaaacaca tctttcctgt cacctttcct ttcaacccat cttccctcgc actagaaacc     5520

atccagattc cagccagcct cggcctgggc ttcatttcac gggtctga                  5568


<210> 26
<211> 1855
<212> PRT
<213> Homo sapiens


<400> 26
Met Ala Ala Ser Glu Leu Tyr Thr Lys Phe Ala Arg Val Trp Ile Pro 
1               5                   10                  15      
Asp Pro Glu Glu Val Trp Lys Ser Ala Glu Leu Leu Lys Asp Tyr Lys 
            20                  25                  30          
Pro Gly Asp Lys Val Leu Leu Leu His Leu Glu Glu Gly Lys Asp Leu 
        35                  40                  45              
Glu Tyr His Leu Asp Pro Lys Thr Lys Glu Leu Pro His Leu Arg Asn 
    50                  55                  60                  
Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  
His Glu Pro Ala Val Leu His Asn Leu Arg Val Arg Phe Ile Asp Ser 
                85                  90                  95      
Lys Leu Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         
Tyr Glu Gln Leu Pro Ile Tyr Gly Glu Asp Ile Ile Asn Ala Tyr Ser 
        115                 120                 125             
Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 
Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Arg Asn Gln Ser Ile Ile 
145                 150                 155                 160 
Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     
Met Arg Tyr Phe Ala Thr Val Ser Gly Ser Ala Ser Glu Ala Asn Val 
            180                 185                 190         
Glu Glu Lys Val Leu Ala Ser Asn Pro Ile Met Glu Ser Ile Gly Asn 
        195                 200                 205             
Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 
Glu Ile Gly Phe Asp Lys Arg Tyr Arg Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 
Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Glu Glu Glu 
                245                 250                 255     
Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ser Ala Lys Leu Pro 
            260                 265                 270         
Glu Phe Lys Met Leu Arg Leu Gly Asn Ala Asp Asn Phe Asn Tyr Thr 
        275                 280                 285             
Lys Gln Gly Gly Ser Pro Val Ile Glu Gly Val Asp Asp Ala Lys Glu 
    290                 295                 300                 
Met Ala His Thr Arg Gln Ala Cys Thr Leu Leu Gly Ile Ser Glu Ser 
305                 310                 315                 320 
His Gln Met Gly Ile Phe Arg Ile Leu Ala Gly Ile Leu His Leu Gly 
                325                 330                 335     
Asn Val Gly Phe Thr Ser Arg Asp Ala Asp Ser Cys Thr Ile Pro Pro 
            340                 345                 350         
Lys His Glu Pro Leu Cys Ile Phe Cys Glu Leu Met Gly Val Asp Tyr 
        355                 360                 365             
Glu Glu Met Cys His Trp Leu Cys His Arg Lys Leu Ala Thr Ala Thr 
    370                 375                 380                 
Glu Thr Tyr Ile Lys Pro Ile Ser Lys Leu Gln Ala Thr Asn Ala Arg 
385                 390                 395                 400 
Asp Ala Leu Ala Lys His Ile Tyr Ala Lys Leu Phe Asn Trp Ile Val 
                405                 410                 415     
Asp Asn Val Asn Gln Ala Leu His Ser Ala Val Lys Gln His Ser Phe 
            420                 425                 430         
Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Ile Asn Ser 
        435                 440                 445             
Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln 
    450                 455                 460                 
Phe Asn Met His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu 
465                 470                 475                 480 
Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys Ile 
                485                 490                 495     
Asn Leu Ile Glu Ser Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu Glu 
            500                 505                 510         
Cys Lys Met Pro Lys Gly Thr Asp Asp Thr Trp Ala Gln Lys Leu Tyr 
        515                 520                 525             
Asn Thr His Leu Asn Lys Cys Ala Leu Phe Glu Lys Pro Arg Leu Ser 
    530                 535                 540                 
Asn Lys Ala Phe Ile Ile Gln His Phe Ala Asp Lys Val Glu Tyr Gln 
545                 550                 555                 560 
Cys Glu Gly Phe Leu Glu Lys Asn Lys Asp Thr Val Phe Glu Glu Gln 
                565                 570                 575     
Ile Lys Val Leu Lys Ser Ser Lys Phe Lys Met Leu Pro Glu Leu Phe 
            580                 585                 590         
Gln Asp Asp Glu Lys Ala Ile Ser Pro Thr Ser Ala Thr Ser Ser Gly 
        595                 600                 605             
Arg Thr Pro Leu Thr Arg Thr Pro Ala Lys Pro Thr Lys Gly Arg Pro 
    610                 615                 620                 
Gly Gln Met Ala Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg 
625                 630                 635                 640 
Asn Ser Leu His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His 
                645                 650                 655     
Tyr Val Arg Cys Ile Lys Pro Asn Asp Phe Lys Phe Pro Phe Thr Phe 
            660                 665                 670         
Asp Glu Lys Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu 
        675                 680                 685             
Thr Ile Arg Ile Ser Ala Ala Gly Phe Pro Ser Arg Trp Thr Tyr Gln 
    690                 695                 700                 
Glu Phe Phe Ser Arg Tyr Arg Val Leu Met Lys Gln Lys Asp Val Leu 
705                 710                 715                 720 
Ser Asp Arg Lys Gln Thr Cys Lys Asn Val Leu Glu Lys Leu Ile Leu 
                725                 730                 735     
Asp Lys Asp Lys Tyr Gln Phe Gly Lys Thr Lys Ile Phe Phe Arg Ala 
            740                 745                 750         
Gly Gln Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Leu Arg Ala 
        755                 760                 765             
Ala Cys Ile Arg Ile Gln Lys Thr Ile Arg Gly Trp Leu Leu Arg Lys 
    770                 775                 780                 
Lys Tyr Leu Arg Met Arg Lys Ala Ala Ile Thr Met Gln Arg Tyr Val 
785                 790                 795                 800 
Arg Gly Tyr Gln Ala Arg Cys Tyr Ala Lys Phe Leu Arg Arg Thr Lys 
                805                 810                 815     
Ala Ala Thr Ile Ile Gln Lys Tyr Trp Arg Met Tyr Val Val Arg Arg 
            820                 825                 830         
Arg Tyr Lys Ile Arg Arg Ala Ala Thr Ile Val Leu Gln Ser Tyr Leu 
        835                 840                 845             
Arg Gly Phe Leu Ala Arg Asn Arg Tyr Arg Lys Ile Leu Arg Glu His 
    850                 855                 860                 
Lys Ala Val Ile Ile Gln Lys Arg Val Arg Gly Trp Leu Ala Arg Thr 
865                 870                 875                 880 
His Tyr Lys Arg Ser Met His Ala Ile Ile Tyr Leu Gln Cys Cys Phe 
                885                 890                 895     
Arg Arg Met Met Ala Lys Arg Glu Leu Lys Lys Leu Lys Ile Glu Ala 
            900                 905                 910         
Arg Ser Val Glu Arg Tyr Lys Lys Leu His Ile Gly Met Glu Asn Lys 
        915                 920                 925             
Ile Met Gln Leu Gln Arg Lys Val Asp Glu Gln Asn Lys Asp Tyr Lys 
    930                 935                 940                 
Cys Leu Val Glu Lys Leu Thr Asn Leu Glu Gly Ile Tyr Asn Ser Glu 
945                 950                 955                 960 
Thr Glu Lys Leu Arg Ser Asp Leu Glu Arg Leu Gln Leu Ser Glu Glu 
                965                 970                 975     
Glu Ala Lys Val Ala Thr Gly Arg Val Leu Ser Leu Gln Glu Glu Ile 
            980                 985                 990         
Ala Lys Leu Arg Lys Asp Leu Glu Gln Thr Arg Ser Glu Lys Lys Cys 
        995                 1000                1005            
Ile Glu Glu His Ala Asp Arg Tyr Lys Gln Glu Thr Glu Gln Leu Val 
    1010                1015                1020                
Ser Asn Leu Lys Glu Glu Asn Thr Leu Leu Lys Gln Glu Lys Glu Ala 
1025                1030                1035                1040
Leu Asn His Arg Ile Val Gln Gln Ala Lys Glu Met Thr Glu Thr Met 
                1045                1050                1055    
Glu Lys Lys Leu Val Glu Glu Thr Lys Gln Leu Glu Leu Asp Leu Asn 
            1060                1065                1070        
Asp Glu Arg Leu Arg Tyr Gln Asn Leu Leu Asn Glu Phe Ser Arg Leu 
        1075                1080                1085            
Glu Glu Arg Tyr Asp Asp Leu Lys Glu Glu Met Thr Leu Met Val His 
    1090                1095                1100                
Val Pro Lys Pro Gly His Lys Arg Thr Asp Ser Thr His Ser Ser Asn 
1105                1110                1115                1120
Glu Ser Glu Tyr Ile Phe Ser Ser Glu Ile Ala Glu Met Glu Asp Ile 
                1125                1130                1135    
Pro Ser Arg Thr Glu Glu Pro Ser Glu Lys Lys Val Pro Leu Asp Met 
            1140                1145                1150        
Ser Leu Phe Leu Lys Leu Gln Lys Arg Val Thr Glu Leu Glu Gln Glu 
        1155                1160                1165            
Lys Gln Val Met Gln Asp Glu Leu Asp Arg Lys Glu Glu Gln Val Leu 
    1170                1175                1180                
Arg Ser Lys Ala Lys Glu Glu Glu Arg Pro Gln Ile Arg Gly Ala Glu 
1185                1190                1195                1200
Leu Glu Tyr Glu Ser Leu Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys 
                1205                1210                1215    
Lys Leu Lys Asn Glu Leu Asn Glu Leu Arg Lys Ala Leu Ser Glu Lys 
            1220                1225                1230        
Ser Ala Pro Glu Val Thr Ala Pro Gly Ala Pro Ala Tyr Arg Val Leu 
        1235                1240                1245            
Met Glu Gln Leu Thr Ser Val Ser Glu Glu Leu Asp Val Arg Lys Glu 
    1250                1255                1260                
Glu Val Leu Ile Leu Arg Ser Gln Leu Val Ser Gln Lys Glu Ala Ile 
1265                1270                1275                1280
Gln Pro Lys Asp Asp Lys Asn Thr Met Thr Asp Ser Thr Ile Leu Leu 
                1285                1290                1295    
Glu Asp Val Gln Lys Met Lys Asp Lys Gly Glu Ile Ala Gln Ala Tyr 
            1300                1305                1310        
Ile Gly Leu Lys Glu Thr Asn Arg Ser Ser Ala Leu Asp Tyr His Glu 
        1315                1320                1325            
Leu Asn Glu Asp Gly Glu Leu Trp Leu Val Tyr Glu Gly Leu Lys Gln 
    1330                1335                1340                
Ala Asn Arg Leu Leu Glu Ser Gln Leu Gln Ser Gln Lys Arg Ser His 
1345                1350                1355                1360
Glu Asn Glu Ala Glu Ala Leu Arg Gly Glu Ile Gln Ser Leu Lys Glu 
                1365                1370                1375    
Glu Asn Asn Arg Gln Gln Gln Leu Leu Ala Gln Asn Leu Gln Leu Pro 
            1380                1385                1390        
Pro Glu Ala Arg Ile Glu Ala Ser Leu Gln His Glu Ile Thr Arg Leu 
        1395                1400                1405            
Thr Asn Glu Asn Leu Asp Leu Met Glu Gln Leu Glu Lys Gln Asp Lys 
    1410                1415                1420                
Thr Val Arg Lys Leu Lys Lys Gln Leu Lys Val Phe Ala Lys Lys Ile 
1425                1430                1435                1440
Gly Glu Leu Glu Val Gly Gln Met Glu Asn Ile Ser Pro Gly Gln Ile 
                1445                1450                1455    
Ile Asp Glu Pro Ile Arg Pro Val Asn Ile Pro Arg Lys Glu Lys Asp 
            1460                1465                1470        
Phe Gln Gly Met Leu Glu Tyr Lys Lys Glu Asp Glu Gln Lys Leu Val 
        1475                1480                1485            
Lys Asn Leu Ile Leu Glu Leu Lys Pro Arg Gly Val Ala Val Asn Leu 
    1490                1495                1500                
Ile Pro Gly Leu Pro Ala Tyr Ile Leu Phe Met Cys Val Arg His Ala 
1505                1510                1515                1520
Asp Tyr Leu Asn Asp Asp Gln Lys Val Arg Ser Leu Leu Thr Ser Thr 
                1525                1530                1535    
Ile Asn Ser Ile Lys Lys Val Leu Lys Lys Arg Gly Asp Asp Phe Glu 
            1540                1545                1550        
Thr Val Ser Phe Trp Leu Ser Asn Thr Cys Arg Phe Leu His Cys Leu 
        1555                1560                1565            
Lys Gln Tyr Ser Gly Glu Glu Gly Phe Met Lys His Asn Thr Ser Arg 
    1570                1575                1580                
Gln Asn Glu His Cys Leu Thr Asn Phe Asp Leu Ala Glu Tyr Arg Gln 
1585                1590                1595                1600
Val Leu Ser Asp Leu Ala Ile Gln Ile Tyr Gln Gln Leu Val Arg Val 
                1605                1610                1615    
Leu Glu Asn Ile Leu Gln Pro Met Ile Val Ser Gly Met Leu Glu His 
            1620                1625                1630        
Glu Thr Ile Gln Gly Val Ser Gly Val Lys Pro Thr Gly Leu Arg Lys 
        1635                1640                1645            
Arg Thr Ser Ser Ile Ala Asp Glu Gly Thr Tyr Thr Leu Asp Ser Ile 
    1650                1655                1660                
Leu Arg Gln Leu Asn Ser Phe His Ser Val Met Cys Gln His Gly Met 
1665                1670                1675                1680
Asp Pro Glu Leu Ile Lys Gln Val Val Lys Gln Met Phe Tyr Ile Ile 
                1685                1690                1695    
Gly Ala Ile Thr Leu Asn Asn Leu Leu Leu Arg Lys Asp Met Cys Ser 
            1700                1705                1710        
Trp Ser Lys Gly Met Gln Ile Arg Tyr Asn Val Ser Gln Leu Glu Glu 
        1715                1720                1725            
Trp Leu Arg Asp Lys Asn Leu Met Asn Ser Gly Ala Lys Glu Thr Leu 
    1730                1735                1740                
Glu Pro Leu Ile Gln Ala Ala Gln Leu Leu Gln Val Lys Lys Lys Thr 
1745                1750                1755                1760
Asp Asp Asp Ala Glu Ala Ile Cys Ser Met Cys Asn Ala Leu Thr Thr 
                1765                1770                1775    
Ala Gln Ile Val Lys Val Leu Asn Leu Tyr Thr Pro Val Asn Glu Phe 
            1780                1785                1790        
Glu Glu Arg Val Ser Val Ser Phe Ile Arg Thr Ile Gln Met Arg Leu 
        1795                1800                1805            
Arg Asp Arg Lys Asp Ser Pro Gln Leu Leu Met Asp Ala Lys His Ile 
    1810                1815                1820                
Phe Pro Val Thr Phe Pro Phe Asn Pro Ser Ser Leu Ala Leu Glu Thr 
1825                1830                1835                1840
Ile Gln Ile Pro Ala Ser Leu Gly Leu Gly Phe Ile Ser Arg Val 
                1845                1850                1855

<210> 27
<211> 5547
<212> DNA
<213> Homo sapiens


<400> 27
atgtcggtgg gcgagctcta cagccagtgc acaagggtct ggatccctga ccctgatgag       60

gtatggcgct cagctgagtt aaccaaggac tacaaagaag gagacaagag cctacagctc      120

agactggagg atgaaacgat tctggaatac ccaattgatg tacaacgcaa ccagctgccc      180

ttcttacgga atccagatat cttggtggga gaaaatgacc tgactgccct tagctatctt      240

catgagcctg cagttttgca taatttgaag gtccgtttcc tggagtccaa ccatatctac      300

acttactgtg gtatcgtact tgttgccatt aatccttatg aacagttgcc aatctatgga      360

caagatgtca tctataccta cagtggccaa aacatgggag acatggaccc ccacatcttt      420

gctgtggcag aagaagccta caagcagatg gccagagatg agaagaatca gtccatcata      480

gtcagtgggg agtctggagc cgggaagacg gtatcagcca agtatgccat gcgctatttc      540

gccaccgttg gtggctcggc cagtgaaacc aacatcgaag agaaggtgct ggcatccagt      600

cccatcatgg aggccattgg aaatgccaag accacccgca atgacaacag cagccgtttt      660

ggcaagtaca tccagattgg ctttgacaaa aggtaccaca tcatcggggc caacatgagg      720

acttacctct tggagaagtc cagagtggtc ttccaggcag atgatgagag gaattaccac      780

atcttttacc agctctgtgc tgctgccggt cttccagaat ttaaagagct tgcactaaca      840

agtgcagagg actttttcta tacatcacag ggaggagaca cttccatcga gggtgtggac      900

gatgctgagg actttgagaa gactcgacaa gccttcacac tcctcggagt gaaagagtcc      960

catcagatga gcatttttaa gataattgct tctatcttgc accttggaag tgtggcgatt     1020

caggctgagc gtgatggtga ttcctgtagt atatcacccc aggatgtata cctaagcaac     1080

ttctgccgac tgctaggggt ggagcacagt cagatggagc actggctgtg tcatcgcaag     1140

ctggtcacca cctcggagac ctacgtcaag accatgtccc tgcagcaggt gatcaatgcg     1200

cgcaacgccc tggcgaagca catctatgcc cagttgttcg gctggattgt ggagcacatc     1260

aacaaggccc tgcacacctc cctcaagcag cactccttca tcggggtcct ggacatctat     1320

gggtttgaga catttgaggt aaacagcttt gagcagttct gtatcaacta tgcaaatgaa     1380

aagctccagc agcagttcaa ctcgcatgtt ttcaaactgg agcaagaaga atacatgaag     1440

gaacagatcc cttggaccct gattgatttt tatgataacc aaccttgtat cgacctcatt     1500

gaagccaagc tgggtatctt ggacctgttg gatgaagaat gtaaggtccc caaaggaact     1560

gaccagaact gggctcagaa gctctatgac cggcactcca gcagccagca cttccagaag     1620

ccccgcatgt ccaacacggc cttcatcatc gtccactttg cagacaaggt ggagtacctc     1680

tctgatggtt ttctggagaa aaacagagac acggtgtatg aagagcagat caatatcctg     1740

aaggccagca agttcccact agtggctgac ttgtttcatg atgacaagga ccctgttcct     1800

gccaccaccc ctgggaaggg gtcatcttcg aagatcagcg tccgttctgc cagacccccc     1860

atgaaagtct ccaacaagga gcacaagaaa accgttggcc accagttccg tacctccctg     1920

catctgctca tggagaccct gaatgccacg acacctcact atgtccgctg catcaagccc     1980

aacgatgaga agctcccctt tcactttgac ccaaagagag cagtgcagca actcagagcc     2040

tgcggggtgt tggagacgat tcgaatcagt gcagctggct acccatccag gtgggcctac     2100

catgactttt tcaaccggta tcgggtgctg gtcaagaaga gagagctcgc caacacagac     2160

aaaaaggcca tctgcaggtc tgtcctggag aacctcatca aggaccccga caagttccag     2220

tttggccgca ccaagatctt ctttcgagca ggccaggtgg cctacctgga gaagctgcgg     2280

gctgacaagt tccggacagc caccatcatg atccagaaaa ctgtccgggg atggctgcag     2340

aaggtgaaat atcacaggct gaagggggct accttaaccc tgcagaggta ctgccgggga     2400

cacctggccc gcaggctggc tgagcacctg cggaggatca gagcggctgt ggtgctccag     2460

aaacattacc gcatgcagag ggcccgccag gcctaccaga gggtccgcag agctgccgtt     2520

gttatccagg ccttcacccg ggccatgttt gtgcggagaa cctaccgcca ggtcctcatg     2580

gagcacaagg ccaccaccat ccagaagcac gtgcggggct ggatggcacg caggcacttc     2640

cagcggctgc gggatgcagc cattgtcatc cagtgtgcct tccggatgct caaggccagg     2700

cgggagctga aggccctcag gattgaggcc cgctcagcag agcatctgaa acgtctcaac     2760

gtgggcatgg agaacaaggt ggtccagctg cagcggaaga tcgatgagca gaacaaagag     2820

ttcaagacac tttcagagca gttgtccgtg accacctcaa catacaccat ggaggtagag     2880

cggctgaaga aggagctggt gcactaccag cagagcccag gtgaggacac cagcctcagg     2940

ctgcaggagg aggtggagag cctgcgcaca gagctgcaga gggcccactc ggagcgcaag     3000

atcttggagg acgcccacag cagggagaaa gatgagctga ggaagcgagt tgcagacctg     3060

gagcaagaaa atgctctctt gaaagatgag aaagaacagc tcaacaacca aatcctgtgc     3120

cagtctaaag atgaatttgc ccagaactct gtgaaggaaa atctcatgaa gaaagaactg     3180

gaggaggagc gatcccggta ccagaacctt gtgaaggaat attcacagtt ggagcagaga     3240

tacgacaacc ttcgggatga aatgaccatc ataaagcaaa ctccaggtca taggcggaac     3300

ccatcaaacc aaagtagctt agaatctgac tccaattacc cctccatctc cacatctgag     3360

atcggagaca ctgaggatgc cctccagcag gtggaggaaa ttggcctgga gaaggcagcc     3420

atggacatga cggtcttcct gaagctgcag aagagagtac gggagctgga gcaggagagg     3480

aaaaagctgc aagtgcagct ggagaagaga gaacagcagg acagcaagaa agtccaggcg     3540

gaaccaccac agactgacat agatttggac ccgaatgcag atctggccta caatagtctg     3600

aagaggcaag agctggagtc agagaacaaa aagctgaaga atgacctgaa tgagctgagg     3660

aaagccgtgg ccgaccaagc cacgcagaat aactccagcc acggctcccc agatagctac     3720

agcctcctgc tgaaccagct caagctggcc cacgaggagc tcgaggtgcg caaggaggag     3780

gtgctcatcc tcaggaccca gatcgtgagc gccgaccagc ggcgactcgc cggcaggaac     3840

gcggagccga acattaatgc cagatcaagt tggcctaaca gtgaaaagca tgttgaccag     3900

gaggatgcca ttgaggccta tcacggggtc tgccagacaa acagcaagac tgaggattgg     3960

ggatatttaa atgaagatgg agaactcggc ttggcctacc aaggcctaaa gcaagttgcc     4020

aggctgctgg aggctcagct gcaggcccag agcctggagc atgaggagga ggtggagcat     4080

ctcaaggctc agctcgaggc cctgaaggag gagatggaca aacagcagca gaccttctgc     4140

cagacgctac tgctctcccc agaggcccag gtggaattcg gcgttcagca ggaaatatcc     4200

cggctgacca acgagaatct ggaccttaaa gaactggtag aaaagctgga aaagaatgag     4260

aggaagctca aaaagcaact gaagatttac atgaagaaag cccaggacct agaagctgcc     4320

caggcattgg cccagagtga gaggaagcgc catgagctca acaggcaggt cacggtccag     4380

cggaaagaga aggatttcca gggcatgctg gagtaccaca aagaggacga ggccctcctc     4440

atccggaacc tggtgacaga cttgaagccc cagatgctgt cgggcacagt gccctgtctc     4500

cccgcctaca tcctctacat gtgcatccgg cacgcggact acaccaacga cgatctcaag     4560

gtgcactccc tgctgacctc caccatcaac ggcattaaga aagtcctgaa aaagcacaat     4620

gatgactttg agatgacgtc attctggtta tccaacacct gccgccttct tcactgtctg     4680

aagcagtaca gcggggatga gggcttcatg actcagaaca ctgcaaagca gaatgaacac     4740

tgtcttaaga attttgacct caccgaatac cgtcaggtgc tgagtgacct ttccattcag     4800

atctaccagc agctcattaa aattgccgag ggcgtgttac agccgatgat agtttctgcc     4860

atgttggaaa atgagagcat tcagggtcta tctggtgtga agcccaccgg ctaccggaag     4920

cgctcctcca gcatggcaga tggggataac tcatactgcc tggaagctat catccgccag     4980

atgaatgcct ttcatacagt catgtgtgac cagggcttgg accctgagat catcctgcag     5040

gtattcaaac agctcttcta catgatcaac gcagtgactc ttaacaacct gctcttgcgg     5100

aaggacgtct gctcttggag cacaggcatg caactcaggt acaatataag tcagcttgag     5160

gagtggcttc ggggaagaaa ccttcaccag agtggagcag ttcagaccat ggaacctctg     5220

atccaagcag cccagctcct gcaattaaag aagaaaaccc aggaggacgc agaggctatc     5280

tgctccctgt gtacctccct cagcacccag cagattgtca aaattttaaa cctttatact     5340

cccctgaatg aatttgaaga acgggtaaca gtggccttta tacgaacaat ccaggcacaa     5400

ctacaagagc ggaatgaccc tcagcaactg ctattagatg ccaagcacat gtttcctgtt     5460

ttgtttccat ttaatccatc ttctctaacc atggactcaa tccacatccc agcgtgtctc     5520

aatctggaat tcctcaatga agtctga                                         5547


<210> 28
<211> 1848
<212> PRT
<213> Homo sapiens


<400> 28
Met Ser Val Gly Glu Leu Tyr Ser Gln Cys Thr Arg Val Trp Ile Pro 
1               5                   10                  15      
Asp Pro Asp Glu Val Trp Arg Ser Ala Glu Leu Thr Lys Asp Tyr Lys 
            20                  25                  30          
Glu Gly Asp Lys Ser Leu Gln Leu Arg Leu Glu Asp Glu Thr Ile Leu 
        35                  40                  45              
Glu Tyr Pro Ile Asp Val Gln Arg Asn Gln Leu Pro Phe Leu Arg Asn 
    50                  55                  60                  
Pro Asp Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu 
65                  70                  75                  80  
His Glu Pro Ala Val Leu His Asn Leu Lys Val Arg Phe Leu Glu Ser 
                85                  90                  95      
Asn His Ile Tyr Thr Tyr Cys Gly Ile Val Leu Val Ala Ile Asn Pro 
            100                 105                 110         
Tyr Glu Gln Leu Pro Ile Tyr Gly Gln Asp Val Ile Tyr Thr Tyr Ser 
        115                 120                 125             
Gly Gln Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu 
    130                 135                 140                 
Glu Ala Tyr Lys Gln Met Ala Arg Asp Glu Lys Asn Gln Ser Ile Ile 
145                 150                 155                 160 
Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Lys Tyr Ala 
                165                 170                 175     
Met Arg Tyr Phe Ala Thr Val Gly Gly Ser Ala Ser Glu Thr Asn Ile 
            180                 185                 190         
Glu Glu Lys Val Leu Ala Ser Ser Pro Ile Met Glu Ala Ile Gly Asn 
        195                 200                 205             
Ala Lys Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Ile 
    210                 215                 220                 
Gln Ile Gly Phe Asp Lys Arg Tyr His Ile Ile Gly Ala Asn Met Arg 
225                 230                 235                 240 
Thr Tyr Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ala Asp Asp Glu 
                245                 250                 255     
Arg Asn Tyr His Ile Phe Tyr Gln Leu Cys Ala Ala Ala Gly Leu Pro 
            260                 265                 270         
Glu Phe Lys Glu Leu Ala Leu Thr Ser Ala Glu Asp Phe Phe Tyr Thr 
        275                 280                 285             
Ser Gln Gly Gly Asp Thr Ser Ile Glu Gly Val Asp Asp Ala Glu Asp 
    290                 295                 300                 
Phe Glu Lys Thr Arg Gln Ala Phe Thr Leu Leu Gly Val Lys Glu Ser 
305                 310                 315                 320 
His Gln Met Ser Ile Phe Lys Ile Ile Ala Ser Ile Leu His Leu Gly 
                325                 330                 335     
Ser Val Ala Ile Gln Ala Glu Arg Asp Gly Asp Ser Cys Ser Ile Ser 
            340                 345                 350         
Pro Gln Asp Val Tyr Leu Ser Asn Phe Cys Arg Leu Leu Gly Val Glu 
        355                 360                 365             
His Ser Gln Met Glu His Trp Leu Cys His Arg Lys Leu Val Thr Thr 
    370                 375                 380                 
Ser Glu Thr Tyr Val Lys Thr Met Ser Leu Gln Gln Val Ile Asn Ala 
385                 390                 395                 400 
Arg Asn Ala Leu Ala Lys His Ile Tyr Ala Gln Leu Phe Gly Trp Ile 
                405                 410                 415     
Val Glu His Ile Asn Lys Ala Leu His Thr Ser Leu Lys Gln His Ser 
            420                 425                 430         
Phe Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Glu Val Asn 
        435                 440                 445             
Ser Phe Glu Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln 
    450                 455                 460                 
Gln Phe Asn Ser His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys 
465                 470                 475                 480 
Glu Gln Ile Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Cys 
                485                 490                 495     
Ile Asp Leu Ile Glu Ala Lys Leu Gly Ile Leu Asp Leu Leu Asp Glu 
            500                 505                 510         
Glu Cys Lys Val Pro Lys Gly Thr Asp Gln Asn Trp Ala Gln Lys Leu 
        515                 520                 525             
Tyr Asp Arg His Ser Ser Ser Gln His Phe Gln Lys Pro Arg Met Ser 
    530                 535                 540                 
Asn Thr Ala Phe Ile Ile Val His Phe Ala Asp Lys Val Glu Tyr Leu 
545                 550                 555                 560 
Ser Asp Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Glu Glu Gln 
                565                 570                 575     
Ile Asn Ile Leu Lys Ala Ser Lys Phe Pro Leu Val Ala Asp Leu Phe 
            580                 585                 590         
His Asp Asp Lys Asp Pro Val Pro Ala Thr Thr Pro Gly Lys Gly Ser 
        595                 600                 605             
Ser Ser Lys Ile Ser Val Arg Ser Ala Arg Pro Pro Met Lys Val Ser 
    610                 615                 620                 
Asn Lys Glu His Lys Lys Thr Val Gly His Gln Phe Arg Thr Ser Leu 
625                 630                 635                 640 
His Leu Leu Met Glu Thr Leu Asn Ala Thr Thr Pro His Tyr Val Arg 
                645                 650                 655     
Cys Ile Lys Pro Asn Asp Glu Lys Leu Pro Phe His Phe Asp Pro Lys 
            660                 665                 670         
Arg Ala Val Gln Gln Leu Arg Ala Cys Gly Val Leu Glu Thr Ile Arg 
        675                 680                 685             
Ile Ser Ala Ala Gly Tyr Pro Ser Arg Trp Ala Tyr His Asp Phe Phe 
    690                 695                 700                 
Asn Arg Tyr Arg Val Leu Val Lys Lys Arg Glu Leu Ala Asn Thr Asp 
705                 710                 715                 720 
Lys Lys Ala Ile Cys Arg Ser Val Leu Glu Asn Leu Ile Lys Asp Pro 
                725                 730                 735     
Asp Lys Phe Gln Phe Gly Arg Thr Lys Ile Phe Phe Arg Ala Gly Gln 
            740                 745                 750         
Val Ala Tyr Leu Glu Lys Leu Arg Ala Asp Lys Phe Arg Thr Ala Thr 
        755                 760                 765             
Ile Met Ile Gln Lys Thr Val Arg Gly Trp Leu Gln Lys Val Lys Tyr 
    770                 775                 780                 
His Arg Leu Lys Gly Ala Thr Leu Thr Leu Gln Arg Tyr Cys Arg Gly 
785                 790                 795                 800 
His Leu Ala Arg Arg Leu Ala Glu His Leu Arg Arg Ile Arg Ala Ala 
                805                 810                 815     
Val Val Leu Gln Lys His Tyr Arg Met Gln Arg Ala Arg Gln Ala Tyr 
            820                 825                 830         
Gln Arg Val Arg Arg Ala Ala Val Val Ile Gln Ala Phe Thr Arg Ala 
        835                 840                 845             
Met Phe Val Arg Arg Thr Tyr Arg Gln Val Leu Met Glu His Lys Ala 
    850                 855                 860                 
Thr Thr Ile Gln Lys His Val Arg Gly Trp Met Ala Arg Arg His Phe 
865                 870                 875                 880 
Gln Arg Leu Arg Asp Ala Ala Ile Val Ile Gln Cys Ala Phe Arg Met 
                885                 890                 895     
Leu Lys Ala Arg Arg Glu Leu Lys Ala Leu Arg Ile Glu Ala Arg Ser 
            900                 905                 910         
Ala Glu His Leu Lys Arg Leu Asn Val Gly Met Glu Asn Lys Val Val 
        915                 920                 925             
Gln Leu Gln Arg Lys Ile Asp Glu Gln Asn Lys Glu Phe Lys Thr Leu 
    930                 935                 940                 
Ser Glu Gln Leu Ser Val Thr Thr Ser Thr Tyr Thr Met Glu Val Glu 
945                 950                 955                 960 
Arg Leu Lys Lys Glu Leu Val His Tyr Gln Gln Ser Pro Gly Glu Asp 
                965                 970                 975     
Thr Ser Leu Arg Leu Gln Glu Glu Val Glu Ser Leu Arg Thr Glu Leu 
            980                 985                 990         
Gln Arg Ala His Ser Glu Arg Lys Ile Leu Glu Asp Ala His Ser Arg 
        995                 1000                1005            
Glu Lys Asp Glu Leu Arg Lys Arg Val Ala Asp Leu Glu Gln Glu Asn 
    1010                1015                1020                
Ala Leu Leu Lys Asp Glu Lys Glu Gln Leu Asn Asn Gln Ile Leu Cys 
1025                1030                1035                1040
Gln Ser Lys Asp Glu Phe Ala Gln Asn Ser Val Lys Glu Asn Leu Met 
                1045                1050                1055    
Lys Lys Glu Leu Glu Glu Glu Arg Ser Arg Tyr Gln Asn Leu Val Lys 
            1060                1065                1070        
Glu Tyr Ser Gln Leu Glu Gln Arg Tyr Asp Asn Leu Arg Asp Glu Met 
        1075                1080                1085            
Thr Ile Ile Lys Gln Thr Pro Gly His Arg Arg Asn Pro Ser Asn Gln 
    1090                1095                1100                
Ser Ser Leu Glu Ser Asp Ser Asn Tyr Pro Ser Ile Ser Thr Ser Glu 
1105                1110                1115                1120
Ile Gly Asp Thr Glu Asp Ala Leu Gln Gln Val Glu Glu Ile Gly Leu 
                1125                1130                1135    
Glu Lys Ala Ala Met Asp Met Thr Val Phe Leu Lys Leu Gln Lys Arg 
            1140                1145                1150        
Val Arg Glu Leu Glu Gln Glu Arg Lys Lys Leu Gln Val Gln Leu Glu 
        1155                1160                1165            
Lys Arg Glu Gln Gln Asp Ser Lys Lys Val Gln Ala Glu Pro Pro Gln 
    1170                1175                1180                
Thr Asp Ile Asp Leu Asp Pro Asn Ala Asp Leu Ala Tyr Asn Ser Leu 
1185                1190                1195                1200
Lys Arg Gln Glu Leu Glu Ser Glu Asn Lys Lys Leu Lys Asn Asp Leu 
                1205                1210                1215    
Asn Glu Leu Arg Lys Ala Val Ala Asp Gln Ala Thr Gln Asn Asn Ser 
            1220                1225                1230        
Ser His Gly Ser Pro Asp Ser Tyr Ser Leu Leu Leu Asn Gln Leu Lys 
        1235                1240                1245            
Leu Ala His Glu Glu Leu Glu Val Arg Lys Glu Glu Val Leu Ile Leu 
    1250                1255                1260                
Arg Thr Gln Ile Val Ser Ala Asp Gln Arg Arg Leu Ala Gly Arg Asn 
1265                1270                1275                1280
Ala Glu Pro Asn Ile Asn Ala Arg Ser Ser Trp Pro Asn Ser Glu Lys 
                1285                1290                1295    
His Val Asp Gln Glu Asp Ala Ile Glu Ala Tyr His Gly Val Cys Gln 
            1300                1305                1310        
Thr Asn Ser Lys Thr Glu Asp Trp Gly Tyr Leu Asn Glu Asp Gly Glu 
        1315                1320                1325            
Leu Gly Leu Ala Tyr Gln Gly Leu Lys Gln Val Ala Arg Leu Leu Glu 
    1330                1335                1340                
Ala Gln Leu Gln Ala Gln Ser Leu Glu His Glu Glu Glu Val Glu His 
1345                1350                1355                1360
Leu Lys Ala Gln Leu Glu Ala Leu Lys Glu Glu Met Asp Lys Gln Gln 
                1365                1370                1375    
Gln Thr Phe Cys Gln Thr Leu Leu Leu Ser Pro Glu Ala Gln Val Glu 
            1380                1385                1390        
Phe Gly Val Gln Gln Glu Ile Ser Arg Leu Thr Asn Glu Asn Leu Asp 
        1395                1400                1405            
Leu Lys Glu Leu Val Glu Lys Leu Glu Lys Asn Glu Arg Lys Leu Lys 
    1410                1415                1420                
Lys Gln Leu Lys Ile Tyr Met Lys Lys Ala Gln Asp Leu Glu Ala Ala 
1425                1430                1435                1440
Gln Ala Leu Ala Gln Ser Glu Arg Lys Arg His Glu Leu Asn Arg Gln 
                1445                1450                1455    
Val Thr Val Gln Arg Lys Glu Lys Asp Phe Gln Gly Met Leu Glu Tyr 
            1460                1465                1470        
His Lys Glu Asp Glu Ala Leu Leu Ile Arg Asn Leu Val Thr Asp Leu 
        1475                1480                1485            
Lys Pro Gln Met Leu Ser Gly Thr Val Pro Cys Leu Pro Ala Tyr Ile 
    1490                1495                1500                
Leu Tyr Met Cys Ile Arg His Ala Asp Tyr Thr Asn Asp Asp Leu Lys 
1505                1510                1515                1520
Val His Ser Leu Leu Thr Ser Thr Ile Asn Gly Ile Lys Lys Val Leu 
                1525                1530                1535    
Lys Lys His Asn Asp Asp Phe Glu Met Thr Ser Phe Trp Leu Ser Asn 
            1540                1545                1550        
Thr Cys Arg Leu Leu His Cys Leu Lys Gln Tyr Ser Gly Asp Glu Gly 
        1555                1560                1565            
Phe Met Thr Gln Asn Thr Ala Lys Gln Asn Glu His Cys Leu Lys Asn 
    1570                1575                1580                
Phe Asp Leu Thr Glu Tyr Arg Gln Val Leu Ser Asp Leu Ser Ile Gln 
1585                1590                1595                1600
Ile Tyr Gln Gln Leu Ile Lys Ile Ala Glu Gly Val Leu Gln Pro Met 
                1605                1610                1615    
Ile Val Ser Ala Met Leu Glu Asn Glu Ser Ile Gln Gly Leu Ser Gly 
            1620                1625                1630        
Val Lys Pro Thr Gly Tyr Arg Lys Arg Ser Ser Ser Met Ala Asp Gly 
        1635                1640                1645            
Asp Asn Ser Tyr Cys Leu Glu Ala Ile Ile Arg Gln Met Asn Ala Phe 
    1650                1655                1660                
His Thr Val Met Cys Asp Gln Gly Leu Asp Pro Glu Ile Ile Leu Gln 
1665                1670                1675                1680
Val Phe Lys Gln Leu Phe Tyr Met Ile Asn Ala Val Thr Leu Asn Asn 
                1685                1690                1695    
Leu Leu Leu Arg Lys Asp Val Cys Ser Trp Ser Thr Gly Met Gln Leu 
            1700                1705                1710        
Arg Tyr Asn Ile Ser Gln Leu Glu Glu Trp Leu Arg Gly Arg Asn Leu 
        1715                1720                1725            
His Gln Ser Gly Ala Val Gln Thr Met Glu Pro Leu Ile Gln Ala Ala 
    1730                1735                1740                
Gln Leu Leu Gln Leu Lys Lys Lys Thr Gln Glu Asp Ala Glu Ala Ile 
1745                1750                1755                1760
Cys Ser Leu Cys Thr Ser Leu Ser Thr Gln Gln Ile Val Lys Ile Leu 
                1765                1770                1775    
Asn Leu Tyr Thr Pro Leu Asn Glu Phe Glu Glu Arg Val Thr Val Ala 
            1780                1785                1790        
Phe Ile Arg Thr Ile Gln Ala Gln Leu Gln Glu Arg Asn Asp Pro Gln 
        1795                1800                1805            
Gln Leu Leu Leu Asp Ala Lys His Met Phe Pro Val Leu Phe Pro Phe 
    1810                1815                1820                
Asn Pro Ser Ser Leu Thr Met Asp Ser Ile His Ile Pro Ala Cys Leu 
1825                1830                1835                1840
Asn Leu Glu Phe Leu Asn Glu Val 
                1845            

<210> 29
<211> 5229
<212> DNA
<213> Homo sapiens


<400> 29
atggcggtgg ccgagctgta cacgcagtac aacagggtct ggattcccga tcctgaagaa       60

gtttggaagt ctgctgaaat agccaaggac tacagagttg gtgacaaggt cctgcgactc      120

ctgctggagg atggaacgga gctggattat tctgtcaatc cagaatctct gcctccactt      180

cggaatcctg acatcctcgt gggcgagaat gacctcacgg ctctcagcta tcttcacgag      240

cccgcggtgc tccacaacct cagaatccgc tttgcagaat ccaaactcat ttacacctac      300

agtggaatca ttttggtggc catgaatcct tacaagcagt tgccaatata cggagatgcc      360

atcatccacg cctacagcgg gcagaacatg ggcgatatgg acccacacat atttgccgtg      420

gcagaagagg catacaagca gatggccaga aacaacagaa accagtccat aattgtaagt      480

ggggagtcag gtgctggaaa gacagtgtcg gctcgctatg ccatgaggta ctttgccacc      540

gtcagcaaat cgggcagcaa cgctcacgtg gaagacaagg tcctggcatc caatcccatc      600

accgaggccg ttggaaatgc caagaccacc cgcaatgaca atagtagtcg gtttgggaaa      660

tacacagaaa tcagttttga tgaacaaaat caaattatag gagccaacat gagcacttac      720

ctcctggaga aatccagagt tgtctttcaa tcggaaaatg aacgaaatta ccacattttc      780

tatcagcttt gtgcatctgc acagcagtcg gaatttaaac atcttaaatt ggggagtgcc      840

gaagaattta attatacaag aatgggaggc aatactgtca ttgagggtgt gaatgatcga      900

gctgaaatgg tagagactca aaagaccttc acgcttctgg gtttcaagga ggattttcag      960

atggacgttt ttaaaatcct ggcagccatc ctacatctgg gcaatgtgca gatcaccgcg     1020

gtgggcaacg agaggtcctc agttagtgag gatgacagtc acctgaaggt gttctgtgag     1080

ctcctgggcc tggagagtgg cagagttgct cagtggctgt gcaatcgcaa aatcgtcaca     1140

agctctgaga cggtggtaaa acccatgacc aggcctcagg ctgtcaacgc cagggatgca     1200

ctggccaaaa agatctatgc tcacctgttc gacttcattg tggagagaat taaccaagcg     1260

ttgcagtttt caggcaagca gcacactttt attggtgttt tggacattta tggttttgaa     1320

acctttgatg tgaacagctt tgaacaattt tgcatcaatt acgctaatga aaaactgcaa     1380

caacagttta acatgcatgt cttcaaactg gaacaagaag aatacatgaa ggaagatata     1440

ccttggacgc tgatagattt ttatgacaat caaccagtta ttgacctgat tgaagcaaaa     1500

atgggaattc tggagttact ggatgaagaa tgtttgttac cacatggaac tgatgaaaac     1560

tggcttcaaa agctgtataa taattttgtc aacaggaacc ctttgtttga aaagcctaga     1620

atgtcaaaca catcctttgt catccagcac tttgctgata aggtagagta taaatgtgaa     1680

ggtttcctgg agaaaaacag agacaccgtc tatgacatgc tggttgaaat cctgagagca     1740

agcaagtttc atctctgtgc caactttttt caagaaaatc caactcctcc ttctcctttt     1800

ggttcaatga ttacagttaa atctgcaaag caagtcatca agccaaacag caagcatttc     1860

cggaccacag ttgggagcaa gttccgcagc tctctgtact tgctcatgga gaccctcaat     1920

gcgacgacgc cccactacgt tcgatgcatc aagccaaatg atgagaagtt accctttgaa     1980

tttgactcca aaagaattgt tcagcagctg cgagcctgcg gcgttttaga aacgattcgc     2040

attagtgcac agagctaccc ttccaggtgg acatacatcg agttctacag tcgctacggc     2100

attctcatga ccaagcaaga gctttccttc agcgataaaa aggaggtgtg caaggtggtt     2160

ttacacagac tcatccagga ttctaatcag taccagtttg gtaaaaccaa aattttcttc     2220

agagcaggac aagtggctta tttagagaaa cttcgattgg ataaactgag gcagagttgt     2280

gttatggtac aaaagcacat gcgtggctgg ctccagagga aaaaattcct ccgagagaga     2340

cgagccgccc tgataatcca gcagtacttc cggggtcagc aaactgtgag gaaagctatt     2400

actgcagtgg ccttaaaaga agcttgggca gccataatca ttcagaagca ctgccgcggg     2460

tatcttgttc gcagcctgta tcagttgatt cgcatggcca ccatcacaat gcaggcctac     2520

agccgaggat tcctggcaag gaggaggtat cgaaagatgc tggaggaaca taaggctgtg     2580

atcctacaga aatacgcacg ggcgtggctg gccagacgca gattccagag tatccgacga     2640

ttcgtgctta atattcagct tacttacagg gtccagcgtt tgcagaaaaa gttggaagat     2700

cagaacaaag aaaaccatgg gctggtggag aagctgacta gcctggctgc tcttcgagct     2760

ggggatgtgg aaaagattca gaagctggaa gcagaactag aaaaagcagc cactcacagg     2820

cgaaattacg aggagaaggg gaagagatac agggatgctg tggaagagaa attggcaaag     2880

cttcagaagc ataattcaga actggaaaca cagaaagaac aaatacagct gaagcttcaa     2940

gagaagactg aagagttaaa agaaaaaatg gacaacctca ccaagcagct ctttgatgat     3000

gtacaaaagg aagaacggca aagaatgctt cttgaaaaaa gttttgaact gaaaacacaa     3060

gactatgaga agcagattca gtctttgaaa gaagaaatta aagctctcaa ggatgagaag     3120

atgcaactcc aacacctggt ggagggggag cacgtcactt ctgatggctt gaaggcggaa     3180

gtggcccgcc tgagcaagca ggtcaagaca atctctgagt tcgaaaaaga gatagaacta     3240

cttcaggcac agaagataga tgtggagaaa catgtgcagt cacaaaaacg ggaaatgaga     3300

gaaaagatgt cagagatcac caaacaactt ctcgaaagct atgacattga agatgtaaga     3360

agcaggctct ctgtggaaga tctggaacat ttaaatgagg atggagaact ttggtttgct     3420

tatgaaggac taaagaaagc aacacgtgtt ttggagagcc atttccagtc tcagaaggat     3480

tgctatgaaa aggagattga agctttgaac ttcaaagtgg tgcatctcag tcaagaaatc     3540

aaccacctgc agaagttatt cagagaagaa aatgacatca atgaaagcat ccgtcatgaa     3600

gttaccaggc taacatcaga gaacatgatg atcccagact ttaaacagca aatttcagaa     3660

ttggagaaac agaagcaaga tcttgaaatc cgcctgaatg aacaagctga gaaaatgaaa     3720

ggaaaactag aagaattgtc taatcagtta catcgcagtc aagaggagga aggaacacaa     3780

agaaaggcct tggaagccca aaatgaaata cataccaaag agaaggagaa gctgattgat     3840

aagattcaag aaatgcagga ggccagtgac cacttgaaga aacaatttga aactgaaagt     3900

gaagtcaagt gtaacttccg gcaggaagca tcccggctca ctttggaaaa cagggatctt     3960

gaagaagaat tagacatgaa agacagagtg attaaaaagc tacaagatca agtcaagaca     4020

ctaagcaaga caattggaaa agccaatgat gtgcactcgt cctcaggacc caaggagtac     4080

cttggaatgc tgcaatacaa gagagaagac gaggccaagc tcattcagaa cctcattctt     4140

gacttgaagc cccgtggcgt ggtggtgaac atgatccccg ggctgccggc tcatatcctg     4200

ttcatgtgtg tgcgctacgc agactctctg aatgatgcca acatgctgaa gtccctcatg     4260

aacagcacca ttaatggcat caagcaggtg gttaaggaac atttagaaga ctttgaaatg     4320

ctgtcctttt ggctttccaa cacttgtcat tttctcaatt gcctgaagca gtacagcgga     4380

gaagaggaat tcatgaagca taatagtcca cagcagaata agaattgctt gaacaatttt     4440

gacctttcag aatacagaca gattctcagt gatgtggcta tacgaatata tcatcaattt     4500

attatcataa tggaaaagaa tatccaaccg ataatagttc cgggaatgct ggagtatgag     4560

agcctgcagg gcatttccgg cctgaagccc acaggcttcc ggaagcgctc ctctagcata     4620

gacgacacgg acggctacac catgacctcc gtcctgcaac agctgagcta cttttacacc     4680

accatgtgcc agaacggcct ggaccccgag cttgtgaggc aggcggtgaa gcagctcttc     4740

ttcttgatcg gggcggtcac gctgaacagc ctcttcctgc gcaaggacat gtgctcctgc     4800

agaaaaggga tgcagatcag gtgcaatatc agctacttag aagaatggct taaagataag     4860

aacttgcaga acagcttagc aaaggaaact ttggagcccc tctctcaggc agcctggttg     4920

cttcaggtca agaagaccac agacagtgat gccaaggaga tctacgaacg ctgcacctca     4980

ctgtctgctg tgcagatcat aaagatcctt aattcataca cacctataga tgactttgag     5040

aagagagtga ctccatcctt tgttcgcaaa gtacaggctc tcctaaatag ccgggaggat     5100

tcatcacagc tgatgttgga taccaaatat ctctttcaag tcacatttcc ttttaccccc     5160

tctccacatg ctctggaaat gattcagatc cccagcagtt tcaagctagg ctttctgaat     5220

aggttatag                                                             5229


<210> 30
<211> 1742
<212> PRT
<213> Homo sapiens


<400> 30
Met Ala Val Ala Glu Leu Tyr Thr Gln Tyr Asn Arg Val Trp Ile Pro 
1               5                   10                  15      
Asp Pro Glu Glu Val Trp Lys Ser Ala Glu Ile Ala Lys Asp Tyr Arg 
            20                  25                  30          
Val Gly Asp Lys Val Leu Arg Leu Leu Leu Glu Asp Gly Thr Glu Leu 
        35                  40                  45              
Asp Tyr Ser Val Asn Pro Glu Ser Leu Pro Pro Leu Arg Asn Pro Asp 
    50                  55                  60                  
Ile Leu Val Gly Glu Asn Asp Leu Thr Ala Leu Ser Tyr Leu His Glu 
65                  70                  75                  80  
Pro Ala Val Leu His Asn Leu Arg Ile Arg Phe Ala Glu Ser Lys Leu 
                85                  90                  95      
Ile Tyr Thr Tyr Ser Gly Ile Ile Leu Val Ala Met Asn Pro Tyr Lys 
            100                 105                 110         
Gln Leu Pro Ile Tyr Gly Asp Ala Ile Ile His Ala Tyr Ser Gly Gln 
        115                 120                 125             
Asn Met Gly Asp Met Asp Pro His Ile Phe Ala Val Ala Glu Glu Ala 
    130                 135                 140                 
Tyr Lys Gln Met Ala Arg Asn Asn Arg Asn Gln Ser Ile Ile Val Ser 
145                 150                 155                 160 
Gly Glu Ser Gly Ala Gly Lys Thr Val Ser Ala Arg Tyr Ala Met Arg 
                165                 170                 175     
Tyr Phe Ala Thr Val Ser Lys Ser Gly Ser Asn Ala His Val Glu Asp 
            180                 185                 190         
Lys Val Leu Ala Ser Asn Pro Ile Thr Glu Ala Val Gly Asn Ala Lys 
        195                 200                 205             
Thr Thr Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr Thr Glu Ile 
    210                 215                 220                 
Ser Phe Asp Glu Gln Asn Gln Ile Ile Gly Ala Asn Met Ser Thr Tyr 
225                 230                 235                 240 
Leu Leu Glu Lys Ser Arg Val Val Phe Gln Ser Glu Asn Glu Arg Asn 
                245                 250                 255     
Tyr His Ile Phe Tyr Gln Leu Cys Ala Ser Ala Gln Gln Ser Glu Phe 
            260                 265                 270         
Lys His Leu Lys Leu Gly Ser Ala Glu Glu Phe Asn Tyr Thr Arg Met 
        275                 280                 285             
Gly Gly Asn Thr Val Ile Glu Gly Val Asn Asp Arg Ala Glu Met Val 
    290                 295                 300                 
Glu Thr Gln Lys Thr Phe Thr Leu Leu Gly Phe Lys Glu Asp Phe Gln 
305                 310                 315                 320 
Met Asp Val Phe Lys Ile Leu Ala Ala Ile Leu His Leu Gly Asn Val 
                325                 330                 335     
Gln Ile Thr Ala Val Gly Asn Glu Arg Ser Ser Val Ser Glu Asp Asp 
            340                 345                 350         
Ser His Leu Lys Val Phe Cys Glu Leu Leu Gly Leu Glu Ser Gly Arg 
        355                 360                 365             
Val Ala Gln Trp Leu Cys Asn Arg Lys Ile Val Thr Ser Ser Glu Thr 
    370                 375                 380                 
Val Val Lys Pro Met Thr Arg Pro Gln Ala Val Asn Ala Arg Asp Ala 
385                 390                 395                 400 
Leu Ala Lys Lys Ile Tyr Ala His Leu Phe Asp Phe Ile Val Glu Arg 
                405                 410                 415     
Ile Asn Gln Ala Leu Gln Phe Ser Gly Lys Gln His Thr Phe Ile Gly 
            420                 425                 430         
Val Leu Asp Ile Tyr Gly Phe Glu Thr Phe Asp Val Asn Ser Phe Glu 
        435                 440                 445             
Gln Phe Cys Ile Asn Tyr Ala Asn Glu Lys Leu Gln Gln Gln Phe Asn 
    450                 455                 460                 
Met His Val Phe Lys Leu Glu Gln Glu Glu Tyr Met Lys Glu Asp Ile 
465                 470                 475                 480 
Pro Trp Thr Leu Ile Asp Phe Tyr Asp Asn Gln Pro Val Ile Asp Leu 
                485                 490                 495     
Ile Glu Ala Lys Met Gly Ile Leu Glu Leu Leu Asp Glu Glu Cys Leu 
            500                 505                 510         
Leu Pro His Gly Thr Asp Glu Asn Trp Leu Gln Lys Leu Tyr Asn Asn 
        515                 520                 525             
Phe Val Asn Arg Asn Pro Leu Phe Glu Lys Pro Arg Met Ser Asn Thr 
    530                 535                 540                 
Ser Phe Val Ile Gln His Phe Ala Asp Lys Val Glu Tyr Lys Cys Glu 
545                 550                 555                 560 
Gly Phe Leu Glu Lys Asn Arg Asp Thr Val Tyr Asp Met Leu Val Glu 
                565                 570                 575     
Ile Leu Arg Ala Ser Lys Phe His Leu Cys Ala Asn Phe Phe Gln Glu 
            580                 585                 590         
Asn Pro Thr Pro Pro Ser Pro Phe Gly Ser Met Ile Thr Val Lys Ser 
        595                 600                 605             
Ala Lys Gln Val Ile Lys Pro Asn Ser Lys His Phe Arg Thr Thr Val 
    610                 615                 620                 
Gly Ser Lys Phe Arg Ser Ser Leu Tyr Leu Leu Met Glu Thr Leu Asn 
625                 630                 635                 640 
Ala Thr Thr Pro His Tyr Val Arg Cys Ile Lys Pro Asn Asp Glu Lys 
                645                 650                 655     
Leu Pro Phe Glu Phe Asp Ser Lys Arg Ile Val Gln Gln Leu Arg Ala 
            660                 665                 670         
Cys Gly Val Leu Glu Thr Ile Arg Ile Ser Ala Gln Ser Tyr Pro Ser 
        675                 680                 685             
Arg Trp Thr Tyr Ile Glu Phe Tyr Ser Arg Tyr Gly Ile Leu Met Thr 
    690                 695                 700                 
Lys Gln Glu Leu Ser Phe Ser Asp Lys Lys Glu Val Cys Lys Val Val 
705                 710                 715                 720 
Leu His Arg Leu Ile Gln Asp Ser Asn Gln Tyr Gln Phe Gly Lys Thr 
                725                 730                 735     
Lys Ile Phe Phe Arg Ala Gly Gln Val Ala Tyr Leu Glu Lys Leu Arg 
            740                 745                 750         
Leu Asp Lys Leu Arg Gln Ser Cys Val Met Val Gln Lys His Met Arg 
        755                 760                 765             
Gly Trp Leu Gln Arg Lys Lys Phe Leu Arg Glu Arg Arg Ala Ala Leu 
    770                 775                 780                 
Ile Ile Gln Gln Tyr Phe Arg Gly Gln Gln Thr Val Arg Lys Ala Ile 
785                 790                 795                 800 
Thr Ala Val Ala Leu Lys Glu Ala Trp Ala Ala Ile Ile Ile Gln Lys 
                805                 810                 815     
His Cys Arg Gly Tyr Leu Val Arg Ser Leu Tyr Gln Leu Ile Arg Met 
            820                 825                 830         
Ala Thr Ile Thr Met Gln Ala Tyr Ser Arg Gly Phe Leu Ala Arg Arg 
        835                 840                 845             
Arg Tyr Arg Lys Met Leu Glu Glu His Lys Ala Val Ile Leu Gln Lys 
    850                 855                 860                 
Tyr Ala Arg Ala Trp Leu Ala Arg Arg Arg Phe Gln Ser Ile Arg Arg 
865                 870                 875                 880 
Phe Val Leu Asn Ile Gln Leu Thr Tyr Arg Val Gln Arg Leu Gln Lys 
                885                 890                 895     
Lys Leu Glu Asp Gln Asn Lys Glu Asn His Gly Leu Val Glu Lys Leu 
            900                 905                 910         
Thr Ser Leu Ala Ala Leu Arg Ala Gly Asp Val Glu Lys Ile Gln Lys 
        915                 920                 925             
Leu Glu Ala Glu Leu Glu Lys Ala Ala Thr His Arg Arg Asn Tyr Glu 
    930                 935                 940                 
Glu Lys Gly Lys Arg Tyr Arg Asp Ala Val Glu Glu Lys Leu Ala Lys 
945                 950                 955                 960 
Leu Gln Lys His Asn Ser Glu Leu Glu Thr Gln Lys Glu Gln Ile Gln 
                965                 970                 975     
Leu Lys Leu Gln Glu Lys Thr Glu Glu Leu Lys Glu Lys Met Asp Asn 
            980                 985                 990         
Leu Thr Lys Gln Leu Phe Asp Asp Val Gln Lys Glu Glu Arg Gln Arg 
        995                 1000                1005            
Met Leu Leu Glu Lys Ser Phe Glu Leu Lys Thr Gln Asp Tyr Glu Lys 
    1010                1015                1020                
Gln Ile Gln Ser Leu Lys Glu Glu Ile Lys Ala Leu Lys Asp Glu Lys 
1025                1030                1035                1040
Met Gln Leu Gln His Leu Val Glu Gly Glu His Val Thr Ser Asp Gly 
                1045                1050                1055    
Leu Lys Ala Glu Val Ala Arg Leu Ser Lys Gln Val Lys Thr Ile Ser 
            1060                1065                1070        
Glu Phe Glu Lys Glu Ile Glu Leu Leu Gln Ala Gln Lys Ile Asp Val 
        1075                1080                1085            
Glu Lys His Val Gln Ser Gln Lys Arg Glu Met Arg Glu Lys Met Ser 
    1090                1095                1100                
Glu Ile Thr Lys Gln Leu Leu Glu Ser Tyr Asp Ile Glu Asp Val Arg 
1105                1110                1115                1120
Ser Arg Leu Ser Val Glu Asp Leu Glu His Leu Asn Glu Asp Gly Glu 
                1125                1130                1135    
Leu Trp Phe Ala Tyr Glu Gly Leu Lys Lys Ala Thr Arg Val Leu Glu 
            1140                1145                1150        
Ser His Phe Gln Ser Gln Lys Asp Cys Tyr Glu Lys Glu Ile Glu Ala 
        1155                1160                1165            
Leu Asn Phe Lys Val Val His Leu Ser Gln Glu Ile Asn His Leu Gln 
    1170                1175                1180                
Lys Leu Phe Arg Glu Glu Asn Asp Ile Asn Glu Ser Ile Arg His Glu 
1185                1190                1195                1200
Val Thr Arg Leu Thr Ser Glu Asn Met Met Ile Pro Asp Phe Lys Gln 
                1205                1210                1215    
Gln Ile Ser Glu Leu Glu Lys Gln Lys Gln Asp Leu Glu Ile Arg Leu 
            1220                1225                1230        
Asn Glu Gln Ala Glu Lys Met Lys Gly Lys Leu Glu Glu Leu Ser Asn 
        1235                1240                1245            
Gln Leu His Arg Ser Gln Glu Glu Glu Gly Thr Gln Arg Lys Ala Leu 
    1250                1255                1260                
Glu Ala Gln Asn Glu Ile His Thr Lys Glu Lys Glu Lys Leu Ile Asp 
1265                1270                1275                1280
Lys Ile Gln Glu Met Gln Glu Ala Ser Asp His Leu Lys Lys Gln Phe 
                1285                1290                1295    
Glu Thr Glu Ser Glu Val Lys Cys Asn Phe Arg Gln Glu Ala Ser Arg 
            1300                1305                1310        
Leu Thr Leu Glu Asn Arg Asp Leu Glu Glu Glu Leu Asp Met Lys Asp 
        1315                1320                1325            
Arg Val Ile Lys Lys Leu Gln Asp Gln Val Lys Thr Leu Ser Lys Thr 
    1330                1335                1340                
Ile Gly Lys Ala Asn Asp Val His Ser Ser Ser Gly Pro Lys Glu Tyr 
1345                1350                1355                1360
Leu Gly Met Leu Gln Tyr Lys Arg Glu Asp Glu Ala Lys Leu Ile Gln 
                1365                1370                1375    
Asn Leu Ile Leu Asp Leu Lys Pro Arg Gly Val Val Val Asn Met Ile 
            1380                1385                1390        
Pro Gly Leu Pro Ala His Ile Leu Phe Met Cys Val Arg Tyr Ala Asp 
        1395                1400                1405            
Ser Leu Asn Asp Ala Asn Met Leu Lys Ser Leu Met Asn Ser Thr Ile 
    1410                1415                1420                
Asn Gly Ile Lys Gln Val Val Lys Glu His Leu Glu Asp Phe Glu Met 
1425                1430                1435                1440
Leu Ser Phe Trp Leu Ser Asn Thr Cys His Phe Leu Asn Cys Leu Lys 
                1445                1450                1455    
Gln Tyr Ser Gly Glu Glu Glu Phe Met Lys His Asn Ser Pro Gln Gln 
            1460                1465                1470        
Asn Lys Asn Cys Leu Asn Asn Phe Asp Leu Ser Glu Tyr Arg Gln Ile 
        1475                1480                1485            
Leu Ser Asp Val Ala Ile Arg Ile Tyr His Gln Phe Ile Ile Ile Met 
    1490                1495                1500                
Glu Lys Asn Ile Gln Pro Ile Ile Val Pro Gly Met Leu Glu Tyr Glu 
1505                1510                1515                1520
Ser Leu Gln Gly Ile Ser Gly Leu Lys Pro Thr Gly Phe Arg Lys Arg 
                1525                1530                1535    
Ser Ser Ser Ile Asp Asp Thr Asp Gly Tyr Thr Met Thr Ser Val Leu 
            1540                1545                1550        
Gln Gln Leu Ser Tyr Phe Tyr Thr Thr Met Cys Gln Asn Gly Leu Asp 
        1555                1560                1565            
Pro Glu Leu Val Arg Gln Ala Val Lys Gln Leu Phe Phe Leu Ile Gly 
    1570                1575                1580                
Ala Val Thr Leu Asn Ser Leu Phe Leu Arg Lys Asp Met Cys Ser Cys 
1585                1590                1595                1600
Arg Lys Gly Met Gln Ile Arg Cys Asn Ile Ser Tyr Leu Glu Glu Trp 
                1605                1610                1615    
Leu Lys Asp Lys Asn Leu Gln Asn Ser Leu Ala Lys Glu Thr Leu Glu 
            1620                1625                1630        
Pro Leu Ser Gln Ala Ala Trp Leu Leu Gln Val Lys Lys Thr Thr Asp 
        1635                1640                1645            
Ser Asp Ala Lys Glu Ile Tyr Glu Arg Cys Thr Ser Leu Ser Ala Val 
    1650                1655                1660                
Gln Ile Ile Lys Ile Leu Asn Ser Tyr Thr Pro Ile Asp Asp Phe Glu 
1665                1670                1675                1680
Lys Arg Val Thr Pro Ser Phe Val Arg Lys Val Gln Ala Leu Leu Asn 
                1685                1690                1695    
Ser Arg Glu Asp Ser Ser Gln Leu Met Leu Asp Thr Lys Tyr Leu Phe 
            1700                1705                1710        
Gln Val Thr Phe Pro Phe Thr Pro Ser Pro His Ala Leu Glu Met Ile 
        1715                1720                1725            
Gln Ile Pro Ser Ser Phe Lys Leu Gly Phe Leu Asn Arg Leu 
    1730                1735                1740        

<210> 31
<211> 6648
<212> DNA
<213> Homo sapiens


<400> 31
atggtgattc ttcagcaggg ggaccatgtg tggatggacc tgagattggg gcaggagttc       60

gacgtgccca tcggggcggt ggtgaagctc tgcgactctg ggcaggtcca ggtggtggat      120

gatgaagaca atgaacactg gatctctccg cagaacgcaa cgcacatcaa gcctatgcac      180

cccacgtcgg tccacggcgt ggaggacatg atccgcctgg gggacctcaa cgaggcgggc      240

atcttgcgca acctgcttat ccgctaccgg gaccacctca tctacacgta tacgggctcc      300

atcctggtgg ctgtgaaccc ctaccagctg ctctccatct actcgccaga gcacatccgc      360

cagtatacca acaagaagat tggggagatg cccccccaca tctttgccat tgctgacaac      420

tgctacttca acatgaaacg caacagccga gaccagtgct gcatcatcag tggggaatct      480

ggggccggga agacggagag cacaaagctg atcctgcagt tcctggcagc catcagtggg      540

cagcactcgt ggattgagca gcaggtcttg gaggccaccc ccattctgga agcatttggg      600

aatgccaaga ccatccgcaa tgacaactca agccgtttcg gaaagtacat cgacatccac      660

ttcaacaagc ggggcgccat cgagggcgcg aagattgagc agtacctgct ggaaaagtca      720

cgtgtctgtc gccaggccct ggatgaaagg aactaccacg tgttctactg catgctggag      780

ggtatgagtg aggatcagaa gaagaagctg ggcttgggcc aggcctctga ctacaactac      840

ttggccatgg gtaactgcat aacctgtgag ggccgggtgg acagccagga gtacgccaac      900

atccgctccg ccatgaaggt gctcatgttc actgacaccg agaactggga gatctcgaag      960

ctcctggctg ccatcctgca cctgggcaac ctgcagtatg aggcacgcac atttgaaaac     1020

ctggatgcct gtgaggttct cttctcccca tcgctggcca cagctgcatc cctgcttgag     1080

gtgaaccccc cagacctgat gagctgcctg actagccgca ccctcatcac ccgcggggag     1140

acggtgtcca ccccactgag cagggaacag gcactggacg tgcgcgacgc cttcgtaaag     1200

gggatctacg ggcggctgtt cgtgtggatt gtggacaaga tcaacgcagc aatttacaag     1260

cctccctccc aggatgtgaa gaactctcgc aggtccatcg gcctcctgga catctttggg     1320

tttgagaact ttgctgtgaa cagctttgag cagctctgca tcaacttcgc caatgagcac     1380

ctgcagcagt tctttgtgcg gcacgtgttc aagctggagc aggaggaata tgacctggag     1440

agcattgact ggctgcacat cgagttcact gacaaccagg atgccctgga catgattgcc     1500

aacaagccca tgaacatcat ctccctcatc gatgaggaga gcaagttccc caagggcaca     1560

gacaccacca tgttacacaa gctgaactcc cagcacaagc tcaacgccaa ctacatcccc     1620

cccaagaaca accatgagac ccagtttggc atcaaccatt ttgcaggcat cgtctactat     1680

gagacccaag gcttcctgga gaagaaccga gacaccctgc atggggacat tatccagctg     1740

gtccactcct ccaggaacaa gttcatcaag cagatcttcc aggccgatgt cgccatgggc     1800

gccgagacca ggaagcgctc gcccacactt agcagccagt tcaagcggtc actggagctg     1860

ctgatgcgca cgctgggtgc ctgccagccc ttctttgtgc gatgcatcaa gcccaatgag     1920

ttcaagaagc ccatgctgtt cgaccggcac ctgtgcgtgc gccagctgcg gtactcagga     1980

atgatggaga ccatccgaat ccgccgagct ggctacccca tccgctacag cttcgtagag     2040

tttgtggagc ggtaccgtgt gctgctgcca ggtgtgaagc cggcctacaa gcagggcgac     2100

ctccgcggga cttgccagcg catggctgag gctgtgctgg gcacccacga tgactggcag     2160

ataggcaaaa ccaagatctt tctgaaggac caccatgaca tgctgctgga agtggagcgg     2220

gacaaagcca tcaccgacag agtcatcctc cttcagaaag tcatccgggg attcaaagac     2280

aggtctaact ttctgaagct gaagaacgct gccacactga tccagaggca ctggcggggt     2340

cacaactgta ggaagaacta cgggctgatg cgtctgggct tcctgcggct gcaggccctg     2400

caccgctccc ggaagctgca ccagcagtac cgcctggccc gccagcgcat catccagttc     2460

caggcccgct gccgcgccta tctggtgcgc aaggccttcc gccaccgcct ctgggctgtg     2520

ctcaccgtgc aggcctatgc ccggggcatg atcgcccgca ggctgcacca acgcctcagg     2580

gctgagtatc tgtggcgcct cgaggctgag aaaatgcggc tggcggagga agagaagctt     2640

cggaaggaga tgagcgccaa gaaggccaag gaggaggccg agcgcaagca tcaggagcgc     2700

ctggcccagc tggctcgtga ggacgctgag cgggagctga aggagaagga ggccgctcgg     2760

cggaagaagg agctcctgga gcagatggaa agggcccgcc atgagcctgt caatcactca     2820

gacatggtgg acaagatgtt tggcttcctg gggacttcag gtggcctgcc aggccaggag     2880

ggccaggcac ctagtggctt tgaggacctg gagcgagggc ggagggagat ggtggaggag     2940

gacctggatg cagccctgcc cctgcctgac gaggatgagg aggacctctc tgagtataaa     3000

tttgccaagt tcgcggccac ctacttccag gggacaacca cgcactccta cacccggcgg     3060

ccactcaaac agccactgct ctaccatgac gacgagggtg accagctggc agccctggcg     3120

gtctggatca ccatcctccg cttcatgggg gacctccctg agcccaagta ccacacagcc     3180

atgagtgatg gcagtgagaa gatccctgtg atgaccaaga tttatgagac cctgggcaag     3240

aagacgtaca agagggagct gcaggccctg cagggcgagg gcgaggccca gctccccgag     3300

ggccagaaga agagcagtgt gaggcacaag ctggtgcatt tgactctgaa aaagaagtcc     3360

aagctcacag aggaggtgac caagaggctg catgacgggg agtccacagt gcagggcaac     3420

agcatgctgg aggaccggcc cacctccaac ctggagaagc tgcacttcat catcggcaat     3480

ggcatcctgc ggccagcact ccgggacgag atctactgcc agatcagcaa gcagctgacc     3540

cacaacccct ccaagagcag ctatgcccgg ggctggattc tcgtgtctct ctgcgtgggc     3600

tgtttcgccc cctccgagaa gtttgtcaag tacctgcgga acttcatcca cgggggcccg     3660

cccggctacg ccccgtactg tgaggagcgc ctgagaagga cctttgtcaa tgggacacgg     3720

acacagccgc ccagctggct ggagctgcag gccaccaagt ccaagaagcc aatcatgttg     3780

cccgtgacat tcatggatgg gaccaccaag accctgctga cggactcggc aaccacggcc     3840

aaggagctct gcaacgcgct ggccgacaag atctctctca aggaccggtt cgggttctcc     3900

ctctacattg ccctgtttga caaggtgtcc tccctgggca gcggcagtga ccacgtcatg     3960

gacgccatct cccagtgcga gcagtacgcc aaggagcagg gcgcccagga gcgcaacgcc     4020

ccctggaggc tcttcttccg caaagaggtc ttcacgccct ggcacagccc ctccgaggac     4080

aacgtggcca ccaacctcat ctaccagcag gtggtgcgag gagtcaagtt tggggagtac     4140

aggtgtgaga aggaggacga cctggctgag ctggcctccc agcagtactt tgtagactat     4200

ggctctgaga tgatcctgga gcgcctcctg aacctcgtgc ccacctacat ccccgaccgc     4260

gagatcacgc ccctgaagac gctggagaag tgggcccagc tggccatcgc cgcccacaag     4320

aaggggattt atgcccagag gagaactgat gcccagaagg tcaaagagga tgtggtcagt     4380

tatgcccgct tcaagtggcc cttgctcttc tccaggtttt atgaagccta caaattctca     4440

ggccccagtc tccccaagaa cgacgtcatc gtggccgtca actggacggg tgtgtacttt     4500

gtggatgagc aggagcaggt acttctggag ctgtccttcc cagagatcat ggccgtgtcc     4560

agcagcaggg agtgccgtgt ctggctctca ctgggctgct ctgatcttgg ctgtgctgcg     4620

cctcactcag gctgggcagg actgaccccg gcggggccct gttctccgtg ttggtcctgc     4680

aggggagcga aaacgacggc ccccagcttc acgctggcca ccatcaaggg ggacgaatac     4740

accttcacct ccagcaatgc tgaggacatt cgtgacctgg tggtcacctt cctagagggg     4800

ctccggaaga gatctaagta tgttgtggcc ctgcaggata accccaaccc cgcaggcgag     4860

gagtcaggct tcctcagctt tgccaaggga gacctcatca tcctggacca tgacacgggc     4920

gagcaggtca tgaactcggg ctgggccaac ggcatcaatg agaggaccaa gcagcgtggg     4980

gacttcccca ccgacagtgt gtacgtcatg cccactgtca ccatgccacc gcgggagatt     5040

gtggccctgg tcaccatgac tcccgatcag aggcaggacg ttgtccggct cttgcagctg     5100

cgaacggcgg agcccgaggt gcgtgccaag ccctacacgc tggaggagtt ttcctatgac     5160

tacttcaggc ccccacccaa gcacacgctg agccgtgtca tggtgtccaa ggcccgaggc     5220

aaggaccggc tgtggagcca cacgcgggaa ccgctcaagc aggcgctgct caagaagctc     5280

ctgggcagtg aggagctctc gcaggaggcc tgcctggcct tcattgctgt gctcaagtac     5340

atgggcgact acccgtccaa gaggacacgc tccgtcaacg agctcaccga ccagatcttt     5400

gagggtcccc tgaaagccga gcccctgaag gacgaggcat atgtgcagat cctgaagcag     5460

ctgaccgaca accacatcag gtacagcgag gagcggggtt gggagctgct ctggctgtgc     5520

acgggccttt tcccacccag caacatcctc ctgccccacg tgcagcgctt cctgcagtcc     5580

cgaaagcact gcccactcgc catcgactgc ctgcaacggc tccagaaagc cctgagaaac     5640

gggtcccgga agtaccctcc gcacctggtg gaggtggagg ccatccagca caagaccacc     5700

cagattttcc acaaagtcta cttccctgat gacactgacg aggccttcga agtggagtcc     5760

agcaccaagg ccaaggactt ctgccagaac atcgccacca ggctgctcct caagtcctca     5820

gagggattca gcctctttgt caaaattgca gacaaggtcc tcagcgttcc tgagaatgac     5880

ttcttctttg actttgttcg acacttgaca gactggataa agaaagctcg gcccatcaag     5940

gacggaattg tgccctcact cacctaccag gtgttcttca tgaagaagct gtggaccacc     6000

acggtgccag ggaaggatcc catggccgat tccatcttcc actattacca ggagttgccc     6060

aagtatctcc gaggctacca caagtgcacg cgggaggagg tgctgcagct gggggcgctg     6120

atctacaggg tcaagttcga ggaggacaag tcctacttcc ccagcatccc caagctgctg     6180

cgggagctgg tgccccagga ccttatccgg caggtctcac ctgatgactg gaagcggtcc     6240

atcgtcgcct acttcaacaa gcacgcaggg aagtccaagg aggaggccaa gctggccttc     6300

ctgaagctca tcttcaagtg gcccaccttt ggctcagcct tcttcgaggt gaagcaaact     6360

acggagccaa acttccctga gatcctccta attgccatca acaagtatgg ggtcagcctc     6420

atcgatccca aaacgaagga tatcctcacc actcatccct tcaccaagat ctccaactgg     6480

agcagcggca acacctactt ccacatcacc attgggaact tggtgcgcgg gagcaaactg     6540

ctctgcgaga cgtcactggg ctacaagatg gatgacctcc tgacttccta cattagccag     6600

atgctcacag ccatgagcaa acagcggggc tccaggagcg gcaagtga                  6648


<210> 32
<211> 2215
<212> PRT
<213> Homo sapiens


<400> 32
Met Val Ile Leu Gln Gln Gly Asp His Val Trp Met Asp Leu Arg Leu 
1               5                   10                  15      
Gly Gln Glu Phe Asp Val Pro Ile Gly Ala Val Val Lys Leu Cys Asp 
            20                  25                  30          
Ser Gly Gln Val Gln Val Val Asp Asp Glu Asp Asn Glu His Trp Ile 
        35                  40                  45              
Ser Pro Gln Asn Ala Thr His Ile Lys Pro Met His Pro Thr Ser Val 
    50                  55                  60                  
His Gly Val Glu Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  
Ile Leu Arg Asn Leu Leu Ile Arg Tyr Arg Asp His Leu Ile Tyr Thr 
                85                  90                  95      
Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Tyr Gln Leu Leu Ser 
            100                 105                 110         
Ile Tyr Ser Pro Glu His Ile Arg Gln Tyr Thr Asn Lys Lys Ile Gly 
        115                 120                 125             
Glu Met Pro Pro His Ile Phe Ala Ile Ala Asp Asn Cys Tyr Phe Asn 
    130                 135                 140                 
Met Lys Arg Asn Ser Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 
Gly Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     
Ala Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         
Thr Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             
Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile His Phe Asn Lys Arg 
    210                 215                 220                 
Gly Ala Ile Glu Gly Ala Lys Ile Glu Gln Tyr Leu Leu Glu Lys Ser 
225                 230                 235                 240 
Arg Val Cys Arg Gln Ala Leu Asp Glu Arg Asn Tyr His Val Phe Tyr 
                245                 250                 255     
Cys Met Leu Glu Gly Met Ser Glu Asp Gln Lys Lys Lys Leu Gly Leu 
            260                 265                 270         
Gly Gln Ala Ser Asp Tyr Asn Tyr Leu Ala Met Gly Asn Cys Ile Thr 
        275                 280                 285             
Cys Glu Gly Arg Val Asp Ser Gln Glu Tyr Ala Asn Ile Arg Ser Ala 
    290                 295                 300                 
Met Lys Val Leu Met Phe Thr Asp Thr Glu Asn Trp Glu Ile Ser Lys 
305                 310                 315                 320 
Leu Leu Ala Ala Ile Leu His Leu Gly Asn Leu Gln Tyr Glu Ala Arg 
                325                 330                 335     
Thr Phe Glu Asn Leu Asp Ala Cys Glu Val Leu Phe Ser Pro Ser Leu 
            340                 345                 350         
Ala Thr Ala Ala Ser Leu Leu Glu Val Asn Pro Pro Asp Leu Met Ser 
        355                 360                 365             
Cys Leu Thr Ser Arg Thr Leu Ile Thr Arg Gly Glu Thr Val Ser Thr 
    370                 375                 380                 
Pro Leu Ser Arg Glu Gln Ala Leu Asp Val Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 
Gly Ile Tyr Gly Arg Leu Phe Val Trp Ile Val Asp Lys Ile Asn Ala 
                405                 410                 415     
Ala Ile Tyr Lys Pro Pro Ser Gln Asp Val Lys Asn Ser Arg Arg Ser 
            420                 425                 430         
Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Ala Val Asn Ser 
        435                 440                 445             
Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 
Phe Val Arg His Val Phe Lys Leu Glu Gln Glu Glu Tyr Asp Leu Glu 
465                 470                 475                 480 
Ser Ile Asp Trp Leu His Ile Glu Phe Thr Asp Asn Gln Asp Ala Leu 
                485                 490                 495     
Asp Met Ile Ala Asn Lys Pro Met Asn Ile Ile Ser Leu Ile Asp Glu 
            500                 505                 510         
Glu Ser Lys Phe Pro Lys Gly Thr Asp Thr Thr Met Leu His Lys Leu 
        515                 520                 525             
Asn Ser Gln His Lys Leu Asn Ala Asn Tyr Ile Pro Pro Lys Asn Asn 
    530                 535                 540                 
His Glu Thr Gln Phe Gly Ile Asn His Phe Ala Gly Ile Val Tyr Tyr 
545                 550                 555                 560 
Glu Thr Gln Gly Phe Leu Glu Lys Asn Arg Asp Thr Leu His Gly Asp 
                565                 570                 575     
Ile Ile Gln Leu Val His Ser Ser Arg Asn Lys Phe Ile Lys Gln Ile 
            580                 585                 590         
Phe Gln Ala Asp Val Ala Met Gly Ala Glu Thr Arg Lys Arg Ser Pro 
        595                 600                 605             
Thr Leu Ser Ser Gln Phe Lys Arg Ser Leu Glu Leu Leu Met Arg Thr 
    610                 615                 620                 
Leu Gly Ala Cys Gln Pro Phe Phe Val Arg Cys Ile Lys Pro Asn Glu 
625                 630                 635                 640 
Phe Lys Lys Pro Met Leu Phe Asp Arg His Leu Cys Val Arg Gln Leu 
                645                 650                 655     
Arg Tyr Ser Gly Met Met Glu Thr Ile Arg Ile Arg Arg Ala Gly Tyr 
            660                 665                 670         
Pro Ile Arg Tyr Ser Phe Val Glu Phe Val Glu Arg Tyr Arg Val Leu 
        675                 680                 685             
Leu Pro Gly Val Lys Pro Ala Tyr Lys Gln Gly Asp Leu Arg Gly Thr 
    690                 695                 700                 
Cys Gln Arg Met Ala Glu Ala Val Leu Gly Thr His Asp Asp Trp Gln 
705                 710                 715                 720 
Ile Gly Lys Thr Lys Ile Phe Leu Lys Asp His His Asp Met Leu Leu 
                725                 730                 735     
Glu Val Glu Arg Asp Lys Ala Ile Thr Asp Arg Val Ile Leu Leu Gln 
            740                 745                 750         
Lys Val Ile Arg Gly Phe Lys Asp Arg Ser Asn Phe Leu Lys Leu Lys 
        755                 760                 765             
Asn Ala Ala Thr Leu Ile Gln Arg His Trp Arg Gly His Asn Cys Arg 
    770                 775                 780                 
Lys Asn Tyr Gly Leu Met Arg Leu Gly Phe Leu Arg Leu Gln Ala Leu 
785                 790                 795                 800 
His Arg Ser Arg Lys Leu His Gln Gln Tyr Arg Leu Ala Arg Gln Arg 
                805                 810                 815     
Ile Ile Gln Phe Gln Ala Arg Cys Arg Ala Tyr Leu Val Arg Lys Ala 
            820                 825                 830         
Phe Arg His Arg Leu Trp Ala Val Leu Thr Val Gln Ala Tyr Ala Arg 
        835                 840                 845             
Gly Met Ile Ala Arg Arg Leu His Gln Arg Leu Arg Ala Glu Tyr Leu 
    850                 855                 860                 
Trp Arg Leu Glu Ala Glu Lys Met Arg Leu Ala Glu Glu Glu Lys Leu 
865                 870                 875                 880 
Arg Lys Glu Met Ser Ala Lys Lys Ala Lys Glu Glu Ala Glu Arg Lys 
                885                 890                 895     
His Gln Glu Arg Leu Ala Gln Leu Ala Arg Glu Asp Ala Glu Arg Glu 
            900                 905                 910         
Leu Lys Glu Lys Glu Ala Ala Arg Arg Lys Lys Glu Leu Leu Glu Gln 
        915                 920                 925             
Met Glu Arg Ala Arg His Glu Pro Val Asn His Ser Asp Met Val Asp 
    930                 935                 940                 
Lys Met Phe Gly Phe Leu Gly Thr Ser Gly Gly Leu Pro Gly Gln Glu 
945                 950                 955                 960 
Gly Gln Ala Pro Ser Gly Phe Glu Asp Leu Glu Arg Gly Arg Arg Glu 
                965                 970                 975     
Met Val Glu Glu Asp Leu Asp Ala Ala Leu Pro Leu Pro Asp Glu Asp 
            980                 985                 990         
Glu Glu Asp Leu Ser Glu Tyr Lys Phe Ala Lys Phe Ala Ala Thr Tyr 
        995                 1000                1005            
Phe Gln Gly Thr Thr Thr His Ser Tyr Thr Arg Arg Pro Leu Lys Gln 
    1010                1015                1020                
Pro Leu Leu Tyr His Asp Asp Glu Gly Asp Gln Leu Ala Ala Leu Ala 
1025                1030                1035                1040
Val Trp Ile Thr Ile Leu Arg Phe Met Gly Asp Leu Pro Glu Pro Lys 
                1045                1050                1055    
Tyr His Thr Ala Met Ser Asp Gly Ser Glu Lys Ile Pro Val Met Thr 
            1060                1065                1070        
Lys Ile Tyr Glu Thr Leu Gly Lys Lys Thr Tyr Lys Arg Glu Leu Gln 
        1075                1080                1085            
Ala Leu Gln Gly Glu Gly Glu Ala Gln Leu Pro Glu Gly Gln Lys Lys 
    1090                1095                1100                
Ser Ser Val Arg His Lys Leu Val His Leu Thr Leu Lys Lys Lys Ser 
1105                1110                1115                1120
Lys Leu Thr Glu Glu Val Thr Lys Arg Leu His Asp Gly Glu Ser Thr 
                1125                1130                1135    
Val Gln Gly Asn Ser Met Leu Glu Asp Arg Pro Thr Ser Asn Leu Glu 
            1140                1145                1150        
Lys Leu His Phe Ile Ile Gly Asn Gly Ile Leu Arg Pro Ala Leu Arg 
        1155                1160                1165            
Asp Glu Ile Tyr Cys Gln Ile Ser Lys Gln Leu Thr His Asn Pro Ser 
    1170                1175                1180                
Lys Ser Ser Tyr Ala Arg Gly Trp Ile Leu Val Ser Leu Cys Val Gly 
1185                1190                1195                1200
Cys Phe Ala Pro Ser Glu Lys Phe Val Lys Tyr Leu Arg Asn Phe Ile 
                1205                1210                1215    
His Gly Gly Pro Pro Gly Tyr Ala Pro Tyr Cys Glu Glu Arg Leu Arg 
            1220                1225                1230        
Arg Thr Phe Val Asn Gly Thr Arg Thr Gln Pro Pro Ser Trp Leu Glu 
        1235                1240                1245            
Leu Gln Ala Thr Lys Ser Lys Lys Pro Ile Met Leu Pro Val Thr Phe 
    1250                1255                1260                
Met Asp Gly Thr Thr Lys Thr Leu Leu Thr Asp Ser Ala Thr Thr Ala 
1265                1270                1275                1280
Lys Glu Leu Cys Asn Ala Leu Ala Asp Lys Ile Ser Leu Lys Asp Arg 
                1285                1290                1295    
Phe Gly Phe Ser Leu Tyr Ile Ala Leu Phe Asp Lys Val Ser Ser Leu 
            1300                1305                1310        
Gly Ser Gly Ser Asp His Val Met Asp Ala Ile Ser Gln Cys Glu Gln 
        1315                1320                1325            
Tyr Ala Lys Glu Gln Gly Ala Gln Glu Arg Asn Ala Pro Trp Arg Leu 
    1330                1335                1340                
Phe Phe Arg Lys Glu Val Phe Thr Pro Trp His Ser Pro Ser Glu Asp 
1345                1350                1355                1360
Asn Val Ala Thr Asn Leu Ile Tyr Gln Gln Val Val Arg Gly Val Lys 
                1365                1370                1375    
Phe Gly Glu Tyr Arg Cys Glu Lys Glu Asp Asp Leu Ala Glu Leu Ala 
            1380                1385                1390        
Ser Gln Gln Tyr Phe Val Asp Tyr Gly Ser Glu Met Ile Leu Glu Arg 
        1395                1400                1405            
Leu Leu Asn Leu Val Pro Thr Tyr Ile Pro Asp Arg Glu Ile Thr Pro 
    1410                1415                1420                
Leu Lys Thr Leu Glu Lys Trp Ala Gln Leu Ala Ile Ala Ala His Lys 
1425                1430                1435                1440
Lys Gly Ile Tyr Ala Gln Arg Arg Thr Asp Ala Gln Lys Val Lys Glu 
                1445                1450                1455    
Asp Val Val Ser Tyr Ala Arg Phe Lys Trp Pro Leu Leu Phe Ser Arg 
            1460                1465                1470        
Phe Tyr Glu Ala Tyr Lys Phe Ser Gly Pro Ser Leu Pro Lys Asn Asp 
        1475                1480                1485            
Val Ile Val Ala Val Asn Trp Thr Gly Val Tyr Phe Val Asp Glu Gln 
    1490                1495                1500                
Glu Gln Val Leu Leu Glu Leu Ser Phe Pro Glu Ile Met Ala Val Ser 
1505                1510                1515                1520
Ser Ser Arg Glu Cys Arg Val Trp Leu Ser Leu Gly Cys Ser Asp Leu 
                1525                1530                1535    
Gly Cys Ala Ala Pro His Ser Gly Trp Ala Gly Leu Thr Pro Ala Gly 
            1540                1545                1550        
Pro Cys Ser Pro Cys Trp Ser Cys Arg Gly Ala Lys Thr Thr Ala Pro 
        1555                1560                1565            
Ser Phe Thr Leu Ala Thr Ile Lys Gly Asp Glu Tyr Thr Phe Thr Ser 
    1570                1575                1580                
Ser Asn Ala Glu Asp Ile Arg Asp Leu Val Val Thr Phe Leu Glu Gly 
1585                1590                1595                1600
Leu Arg Lys Arg Ser Lys Tyr Val Val Ala Leu Gln Asp Asn Pro Asn 
                1605                1610                1615    
Pro Ala Gly Glu Glu Ser Gly Phe Leu Ser Phe Ala Lys Gly Asp Leu 
            1620                1625                1630        
Ile Ile Leu Asp His Asp Thr Gly Glu Gln Val Met Asn Ser Gly Trp 
        1635                1640                1645            
Ala Asn Gly Ile Asn Glu Arg Thr Lys Gln Arg Gly Asp Phe Pro Thr 
    1650                1655                1660                
Asp Ser Val Tyr Val Met Pro Thr Val Thr Met Pro Pro Arg Glu Ile 
1665                1670                1675                1680
Val Ala Leu Val Thr Met Thr Pro Asp Gln Arg Gln Asp Val Val Arg 
                1685                1690                1695    
Leu Leu Gln Leu Arg Thr Ala Glu Pro Glu Val Arg Ala Lys Pro Tyr 
            1700                1705                1710        
Thr Leu Glu Glu Phe Ser Tyr Asp Tyr Phe Arg Pro Pro Pro Lys His 
        1715                1720                1725            
Thr Leu Ser Arg Val Met Val Ser Lys Ala Arg Gly Lys Asp Arg Leu 
    1730                1735                1740                
Trp Ser His Thr Arg Glu Pro Leu Lys Gln Ala Leu Leu Lys Lys Leu 
1745                1750                1755                1760
Leu Gly Ser Glu Glu Leu Ser Gln Glu Ala Cys Leu Ala Phe Ile Ala 
                1765                1770                1775    
Val Leu Lys Tyr Met Gly Asp Tyr Pro Ser Lys Arg Thr Arg Ser Val 
            1780                1785                1790        
Asn Glu Leu Thr Asp Gln Ile Phe Glu Gly Pro Leu Lys Ala Glu Pro 
        1795                1800                1805            
Leu Lys Asp Glu Ala Tyr Val Gln Ile Leu Lys Gln Leu Thr Asp Asn 
    1810                1815                1820                
His Ile Arg Tyr Ser Glu Glu Arg Gly Trp Glu Leu Leu Trp Leu Cys 
1825                1830                1835                1840
Thr Gly Leu Phe Pro Pro Ser Asn Ile Leu Leu Pro His Val Gln Arg 
                1845                1850                1855    
Phe Leu Gln Ser Arg Lys His Cys Pro Leu Ala Ile Asp Cys Leu Gln 
            1860                1865                1870        
Arg Leu Gln Lys Ala Leu Arg Asn Gly Ser Arg Lys Tyr Pro Pro His 
        1875                1880                1885            
Leu Val Glu Val Glu Ala Ile Gln His Lys Thr Thr Gln Ile Phe His 
    1890                1895                1900                
Lys Val Tyr Phe Pro Asp Asp Thr Asp Glu Ala Phe Glu Val Glu Ser 
1905                1910                1915                1920
Ser Thr Lys Ala Lys Asp Phe Cys Gln Asn Ile Ala Thr Arg Leu Leu 
                1925                1930                1935    
Leu Lys Ser Ser Glu Gly Phe Ser Leu Phe Val Lys Ile Ala Asp Lys 
            1940                1945                1950        
Val Leu Ser Val Pro Glu Asn Asp Phe Phe Phe Asp Phe Val Arg His 
        1955                1960                1965            
Leu Thr Asp Trp Ile Lys Lys Ala Arg Pro Ile Lys Asp Gly Ile Val 
    1970                1975                1980                
Pro Ser Leu Thr Tyr Gln Val Phe Phe Met Lys Lys Leu Trp Thr Thr 
1985                1990                1995                2000
Thr Val Pro Gly Lys Asp Pro Met Ala Asp Ser Ile Phe His Tyr Tyr 
                2005                2010                2015    
Gln Glu Leu Pro Lys Tyr Leu Arg Gly Tyr His Lys Cys Thr Arg Glu 
            2020                2025                2030        
Glu Val Leu Gln Leu Gly Ala Leu Ile Tyr Arg Val Lys Phe Glu Glu 
        2035                2040                2045            
Asp Lys Ser Tyr Phe Pro Ser Ile Pro Lys Leu Leu Arg Glu Leu Val 
    2050                2055                2060                
Pro Gln Asp Leu Ile Arg Gln Val Ser Pro Asp Asp Trp Lys Arg Ser 
2065                2070                2075                2080
Ile Val Ala Tyr Phe Asn Lys His Ala Gly Lys Ser Lys Glu Glu Ala 
                2085                2090                2095    
Lys Leu Ala Phe Leu Lys Leu Ile Phe Lys Trp Pro Thr Phe Gly Ser 
            2100                2105                2110        
Ala Phe Phe Glu Val Lys Gln Thr Thr Glu Pro Asn Phe Pro Glu Ile 
        2115                2120                2125            
Leu Leu Ile Ala Ile Asn Lys Tyr Gly Val Ser Leu Ile Asp Pro Lys 
    2130                2135                2140                
Thr Lys Asp Ile Leu Thr Thr His Pro Phe Thr Lys Ile Ser Asn Trp 
2145                2150                2155                2160
Ser Ser Gly Asn Thr Tyr Phe His Ile Thr Ile Gly Asn Leu Val Arg 
                2165                2170                2175    
Gly Ser Lys Leu Leu Cys Glu Thr Ser Leu Gly Tyr Lys Met Asp Asp 
            2180                2185                2190        
Leu Leu Thr Ser Tyr Ile Ser Gln Met Leu Thr Ala Met Ser Lys Gln 
        2195                2200                2205            
Arg Gly Ser Arg Ser Gly Lys 
    2210                2215

<210> 33
<211> 6351
<212> DNA
<213> Homo sapiens


<400> 33
atgtcggggt tcaggctggg tgaccacgtg tggctggagc ctccctccac ccacaagacc       60

ggcgtggcca tcgggggcat catcaaagag gcaaagccag gcaaagtctt ggttgaagat      120

gacgagggca aggaacactg gatccgagca gaggactttg gtgtcctcag tcccatgcac      180

cccaactcag tccagggtgt ggacgacatg atccgcctgg gggacctgaa cgaggcaggc      240

atggtgcaca acctcctgat ccgctaccag cagcacaaga tctatacata cacaggctcc      300

atcctggtgg ccgtcaaccc gttccaggtg ctgccgctct acaccctgga gcaggtacag      360

ctctactaca gccgccatat gggcgagctg cccccgcatg tctttgccat cgccaacaac      420

tgctacttca gcatgaagag gaacaagagg gaccagtgct gcatcatcag cggcgagtct      480

ggggctggca agacggagac caccaagctc atcctgcagt tcctggccac catcagtggc      540

cagcattcgt ggattgagca gcaggtcctg gaagccaacc ccatcctgga ggcctttgga      600

aatgccaaga caatccgcaa cgacaactca agccgctttg ggaagtacat tgacatctac      660

tttaacccca gcggggtgat cgagggcgcg cgcatcgagc aatttctcct ggagaagtcc      720

cgggtctgcc ggcaggctcc cgaggagcgg aactaccata tcttctactg catgctcatg      780

ggggtgagtg ctgaggacaa gcagctgctg agcctgggca cgccctccga gtaccactac      840

ctgaccatgg ggaactgcac ttcctgtgag gggctcaacg acgccaagga ctacgcccac      900

atccgctcgg ccatgaagat cctccagttc tccgactccg agagctggga cgtcatcaag      960

ctgctggctg ccattctcca cctggggaat gtggggttca tggcttcggt cttcgagaac     1020

ctggacgcct cagacgtgat ggagacgccc gcctttccca ccgtgatgaa gttactggag     1080

gtgcagcacc aggagctccg ggactgtctg atcaagcaca ccatcctcat ccgaggggaa     1140

tttgtcacca ggtccctgaa cattgcccag gctgctgacc ggagggacgc ctttgtcaag     1200

ggcatctatg ggcacctctt cctgtggatt gtcaagaaga tcaatgccgc catcttcaca     1260

ccaccagccc aggaccccaa aaatgtgcgg agggccatcg gcctcctgga catatttggc     1320

tttgaaaatt tcgagaacaa tagcttcgag cagctctgca tcaacttcgc caacgagcac     1380

ctgcagcagt tctttgtgca gcacgtgttc accatggagc aagaggagta ccgctcggag     1440

aacatctcct gggactatat ccactacacc gacaatcggc ccaccctgga cctgctggcc     1500

ctcaagccca tgagcatcat ctccctcctg gacgaagaaa gccgcttccc gcaggggaca     1560

gatctcacca tgctgcaaaa gctgaacagc gtccatgcca acaacaaggc cttcctacag     1620

cccaagaaca tccacgatgc cagatttggc attgcccatt ttgccggcga ggtgtactac     1680

caagcagaag gcttcctgga gaagaaccga gacgtgctga gcacagatat cctcaccctg     1740

gtttactcct ccaaaaacaa gtttctgagg gagatattca acttggagtt agcagagacc     1800

aagctgggcc atgggaccat ccgccaggca aaggcaggaa accatctctt caagtctgca     1860

gactcaaata aacggccctc caccttagga agccagttca aacagtctct ggaccagctg     1920

atgaaaatcc tgaccaactg ccagccttac ttcatccgct gcatcaaacc taatgagtac     1980

aagaagccgc tgctgttcga ccgggagctg tgcctgcggc agctgcgata ctcgggcatg     2040

atggagaccg tgcacatccg caagtcgggc ttccccatcc gctacacgtt cgaggagttc     2100

tcgcagaggt tcggcgtgtt gctgcccaac gccatgcgga tgcagctgca aggcaagctc     2160

cgccagatga ccctgggcat cactgacgtg tggctgcgga cagacaaaga ctggaaagcg     2220

gggaagacaa aaattttcct gagggatcat caggacactc tgctggaggt acagagaagc     2280

caggtgctag acagagcggc gctcagcatc cagaaagtcc ttcggggcta cagatacagg     2340

aaggagttcc tgaggcagag gcgggcagct gtgaccctgc aggcctggtg gagaggctac     2400

tgcaacagga ggaatttcaa gctgatcctc gtgggctttg agcgcctgca ggctattgcc     2460

cggagccagc cgctggcgag gcagtaccag gccatgcggc agaggacagt ccagctgcag     2520

gccctgtgca ggggatacct ggtgcgccag caagtccagg ccaagaggag ggcagtggtg     2580

gtcattcagg cccatgccag gggcatggct gcccggcgca acttccagca aaggaaggcc     2640

aatgcgccgc tggtcatccc ggccgagggg cagaaaagcc aaggcgctct ccctgccaag     2700

aagcgcagat ccatctacga caccgtcact gacacggaga tggtggagaa ggtgttcggc     2760

ttcctccctg ccatgattgg gggccaggag ggccaggcct cgccgcactt tgaggatctg     2820

gaatcgaaga cccagaagct gcttgaggtt gacctggaca cagtccccat ggcggaggag     2880

cctgaggagg atgtggatgg cctggccgag tacaccttcc ccaagtttgc tgtgacttac     2940

ttccagaaat cagccagcca cacacacatc cggcggcccc tccgataccc gttgctttac     3000

cacgaagatg acactgactg cttggccgcc ctggtcatat ggaacgtcat cctgaggttc     3060

atgggtgatc tcccagagcc agtgctgtat gccaggagca gccagcaggg cagctcagtg     3120

atgcggcaga tccatgacac gctgggcagg gagcacggtg cccaggttcc acagcacagt     3180

agatctgcac aggtggccag ccagctgaac attggagagg aggcattgga gcctgatggc     3240

cttggtgcag accggcccat gtccaacctg gagaaggtgc acttcatcgt gggctacgcc     3300

atcctgcggc ccagcctcag ggatgagatt tactgccaga tctgcaagca gctctcggag     3360

aacttcaaaa caagcagcct ggcccggggc tggatcctgc tcagcctctg cctcggctgc     3420

ttcccaccct cagagaggtt catgaagtat ctactgaact tcatcggcca agggccggcg     3480

acctacggcc ccttctgtgc cgagcgcctg agacgcacct atgccaatgg ggtgcgtgcg     3540

gagcccccca cctggctgga gctgcaggct gtcaagtcca agaagcacat ccccatccaa     3600

gtcatcttgg ccactggaga gagcctaacc gtccccgtgg actcagcctc cacatctcgg     3660

gaaatgtgca tgcacatcgc tcacaagcag ggcctcagcg accacctggg cttctccctc     3720

caggtcgccg tgtacgacaa gttctggtcc ctgggcagcg ggcgcgacca catgatggat     3780

gccatcgccc ggtgtgagca gatggcccag gagaggggcg agagccagcg ccagtcaccc     3840

tggcgcatct acttccggaa ggaattcttc accccctggc acgactcccg ggaggaccct     3900

gtcagcaccg agcttattta ccgccaagtc ctccgaggag tctggtctgg cgagtacagc     3960

ttcgagaagg aggaagagct ggttgagctg ctggcccggc actgctacgt gcagctcggc     4020

gcctcagcag agagcaaggc tgtccaggag ctgctgccca gctgcatccc ccacaagctg     4080

tacaggacca agcccccaga caggtgggcg agcctcgtca ctgccgcctg cgccaaggcc     4140

ccatacactc agaagcaagt cacaccactg gccgtgcgag agcaggtggt ggacgccgcc     4200

cgcctgcagt ggccgctgct cttctcccgg ctcttcgaag tcatcacact ctcaggcccc     4260

cgcctgccca agacgcagct gatcttggct gttaactgga aggggctttg cttcctggac     4320

cagcaggaga agatgctgct ggaactctct ttcccagagg tcatgggtct ggccaccaac     4380

agggaggccc agggcgggca gaggctgctg ctctccacga tgcatgagga gtacgagttt     4440

gtgtcaccca gcagtgtggc catcgctgag ctggtggccc tgttcctgga gggcctgaag     4500

gagaggtcca ttttcgccat ggccctgcag gacaggaagg ccacagatga caccaccctc     4560

ctggccttca agaaggggga cctgttggtc ctcacaaaga agcaggggct gctggcctct     4620

gagaactgga ccctcggcca gaacgacagg acaggcaaga cggggctggt gcccatggcc     4680

tgcctctaca ccatccccac ggtcactaag ccctcggcac agctgctgag cttgcttgcc     4740

atgtcaccag agaagaggaa gctggcggct caggaggggc agttcacaga gccacgtcct     4800

gaggagccac ccaaggaaaa gctgcacacc ctggaggagt tctcctatga gttcttcagg     4860

gctccagaga aggacatggt gagcatggcc gtgctgcccc tggcccgtgc ccgtggccac     4920

ctgtgggcct attcctgcga gccgctgcga cagccgctgc tcaagcgagt ccacgccaac     4980

gtcgacctct gggacatcgc ctgccagatc tttgtcgcca tcctccggta catgggcgac     5040

tacccttctc ggcaggcctg gcccaccctg gagctcaccg accagatctt cacactggcc     5100

ctgcagcacc cggccctcca ggacgaggtc tactgccaga tcctgaagca gctgacgcac     5160

aactccaaca ggcacagcga agagcggggc tggcagctgc tgtggctgtg cacgggcctc     5220

ttcccgccca gcaaggggct gctgccccat gcccagaagt ttatagacac tcggaggggg     5280

aagctgctgg cccccgactg cagccgccga atccagaagg tcctgaggac ggggccccgg     5340

aagcagcccc cgcaccaggt ggaggtggag gccgcagagc agaacgtctc ccgcatctgc     5400

cacaagatct acttccccaa tgacaccagt gagatgctgg aggtggttgc caacacacgg     5460

gtgcgggatg tgtgtgacag cattgccacc aggctgcagc tggcctcctg ggagggctgc     5520

agcctcttca tcaagatttc agacaaggtc atcagccaga aggagggaga cttcttcttt     5580

gattccttga gggaggtgtc tgactgggtg aagaagaaca agccccagaa agaaggggcc     5640

cccgtgacgc tcccctacca ggtgtacttc atgcggaaat tgtggctcaa catatctcca     5700

gggaaggatg tgaatgcaga caccatactc cattaccacc aggagctgcc caagtacctg     5760

cgcggattcc acaagtgttc gcgggaggat gccatccacc tggcgggcct catctacaag     5820

gcccagttca acaacgaccg gtcccagctg gctagtgtcc ccaagatcct gagggaactg     5880

gtgcctgaga acctcacacg cctgatgtcc tcggaggagt ggaaaaagag catccttcta     5940

gcctatgaca agcataagga caagacagtg gaggaggcca aggtggcctt cctgaagtgg     6000

atctgccggt ggcccacctt cggatccgcc ttcttcgagg tgaagcaaac ctcggagcct     6060

tcctacccgg acgtcatcct catcgccatc aaccgacatg gggttctgct catccacccc     6120

aagaccaagg acctgctcac cacctatccc ttcaccaaga tctccagctg gagcagcggc     6180

agcacctact tccacatggc gctggggagc ctgggccgtg gcagccgcct gctgtgcgag     6240

acctccctgg gctataagat ggatgacctg ctgacctcat atgtgcagca gctcctgagt     6300

gccatgaaca agcagcgggg ctccaaggcc ccagccctgg ccagcaccta g              6351


<210> 34
<211> 2116
<212> PRT
<213> Homo sapiens


<400> 34
Met Ser Gly Phe Arg Leu Gly Asp His Val Trp Leu Glu Pro Pro Ser 
1               5                   10                  15      
Thr His Lys Thr Gly Val Ala Ile Gly Gly Ile Ile Lys Glu Ala Lys 
            20                  25                  30          
Pro Gly Lys Val Leu Val Glu Asp Asp Glu Gly Lys Glu His Trp Ile 
        35                  40                  45              
Arg Ala Glu Asp Phe Gly Val Leu Ser Pro Met His Pro Asn Ser Val 
    50                  55                  60                  
Gln Gly Val Asp Asp Met Ile Arg Leu Gly Asp Leu Asn Glu Ala Gly 
65                  70                  75                  80  
Met Val His Asn Leu Leu Ile Arg Tyr Gln Gln His Lys Ile Tyr Thr 
                85                  90                  95      
Tyr Thr Gly Ser Ile Leu Val Ala Val Asn Pro Phe Gln Val Leu Pro 
            100                 105                 110         
Leu Tyr Thr Leu Glu Gln Val Gln Leu Tyr Tyr Ser Arg His Met Gly 
        115                 120                 125             
Glu Leu Pro Pro His Val Phe Ala Ile Ala Asn Asn Cys Tyr Phe Ser 
    130                 135                 140                 
Met Lys Arg Asn Lys Arg Asp Gln Cys Cys Ile Ile Ser Gly Glu Ser 
145                 150                 155                 160 
Gly Ala Gly Lys Thr Glu Thr Thr Lys Leu Ile Leu Gln Phe Leu Ala 
                165                 170                 175     
Thr Ile Ser Gly Gln His Ser Trp Ile Glu Gln Gln Val Leu Glu Ala 
            180                 185                 190         
Asn Pro Ile Leu Glu Ala Phe Gly Asn Ala Lys Thr Ile Arg Asn Asp 
        195                 200                 205             
Asn Ser Ser Arg Phe Gly Lys Tyr Ile Asp Ile Tyr Phe Asn Pro Ser 
    210                 215                 220                 
Gly Val Ile Glu Gly Ala Arg Ile Glu Gln Phe Leu Leu Glu Lys Ser 
225                 230                 235                 240 
Arg Val Cys Arg Gln Ala Pro Glu Glu Arg Asn Tyr His Ile Phe Tyr 
                245                 250                 255     
Cys Met Leu Met Gly Val Ser Ala Glu Asp Lys Gln Leu Leu Ser Leu 
            260                 265                 270         
Gly Thr Pro Ser Glu Tyr His Tyr Leu Thr Met Gly Asn Cys Thr Ser 
        275                 280                 285             
Cys Glu Gly Leu Asn Asp Ala Lys Asp Tyr Ala His Ile Arg Ser Ala 
    290                 295                 300                 
Met Lys Ile Leu Gln Phe Ser Asp Ser Glu Ser Trp Asp Val Ile Lys 
305                 310                 315                 320 
Leu Leu Ala Ala Ile Leu His Leu Gly Asn Val Gly Phe Met Ala Ser 
                325                 330                 335     
Val Phe Glu Asn Leu Asp Ala Ser Asp Val Met Glu Thr Pro Ala Phe 
            340                 345                 350         
Pro Thr Val Met Lys Leu Leu Glu Val Gln His Gln Glu Leu Arg Asp 
        355                 360                 365             
Cys Leu Ile Lys His Thr Ile Leu Ile Arg Gly Glu Phe Val Thr Arg 
    370                 375                 380                 
Ser Leu Asn Ile Ala Gln Ala Ala Asp Arg Arg Asp Ala Phe Val Lys 
385                 390                 395                 400 
Gly Ile Tyr Gly His Leu Phe Leu Trp Ile Val Lys Lys Ile Asn Ala 
                405                 410                 415     
Ala Ile Phe Thr Pro Pro Ala Gln Asp Pro Lys Asn Val Arg Arg Ala 
            420                 425                 430         
Ile Gly Leu Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Asn Asn Ser 
        435                 440                 445             
Phe Glu Gln Leu Cys Ile Asn Phe Ala Asn Glu His Leu Gln Gln Phe 
    450                 455                 460                 
Phe Val Gln His Val Phe Thr Met Glu Gln Glu Glu Tyr Arg Ser Glu 
465                 470                 475                 480 
Asn Ile Ser Trp Asp Tyr Ile His Tyr Thr Asp Asn Arg Pro Thr Leu 
                485                 490                 495     
Asp Leu Leu Ala Leu Lys Pro Met Ser Ile Ile Ser Leu Leu Asp Glu 
            500                 505                 510         
Glu Ser Arg Phe Pro Gln Gly Thr Asp Leu Thr Met Leu Gln Lys Leu 
        515                 520                 525             
Asn Ser Val His Ala Asn Asn Lys Ala Phe Leu Gln Pro Lys Asn Ile 
    530                 535                 540                 
His Asp Ala Arg Phe Gly Ile Ala His Phe Ala Gly Glu Val Tyr Tyr 
545                 550                 555                 560 
Gln Ala Glu Gly Phe Leu Glu Lys Asn Arg Asp Val Leu Ser Thr Asp 
                565                 570                 575     
Ile Leu Thr Leu Val Tyr Ser Ser Lys Asn Lys Phe Leu Arg Glu Ile 
            580                 585                 590         
Phe Asn Leu Glu Leu Ala Glu Thr Lys Leu Gly His Gly Thr Ile Arg 
        595                 600                 605             
Gln Ala Lys Ala Gly Asn His Leu Phe Lys Ser Ala Asp Ser Asn Lys 
    610                 615                 620                 
Arg Pro Ser Thr Leu Gly Ser Gln Phe Lys Gln Ser Leu Asp Gln Leu 
625                 630                 635                 640 
Met Lys Ile Leu Thr Asn Cys Gln Pro Tyr Phe Ile Arg Cys Ile Lys 
                645                 650                 655     
Pro Asn Glu Tyr Lys Lys Pro Leu Leu Phe Asp Arg Glu Leu Cys Leu 
            660                 665                 670         
Arg Gln Leu Arg Tyr Ser Gly Met Met Glu Thr Val His Ile Arg Lys 
        675                 680                 685             
Ser Gly Phe Pro Ile Arg Tyr Thr Phe Glu Glu Phe Ser Gln Arg Phe 
    690                 695                 700                 
Gly Val Leu Leu Pro Asn Ala Met Arg Met Gln Leu Gln Gly Lys Leu 
705                 710                 715                 720 
Arg Gln Met Thr Leu Gly Ile Thr Asp Val Trp Leu Arg Thr Asp Lys 
                725                 730                 735     
Asp Trp Lys Ala Gly Lys Thr Lys Ile Phe Leu Arg Asp His Gln Asp 
            740                 745                 750         
Thr Leu Leu Glu Val Gln Arg Ser Gln Val Leu Asp Arg Ala Ala Leu 
        755                 760                 765             
Ser Ile Gln Lys Val Leu Arg Gly Tyr Arg Tyr Arg Lys Glu Phe Leu 
    770                 775                 780                 
Arg Gln Arg Arg Ala Ala Val Thr Leu Gln Ala Trp Trp Arg Gly Tyr 
785                 790                 795                 800 
Cys Asn Arg Arg Asn Phe Lys Leu Ile Leu Val Gly Phe Glu Arg Leu 
                805                 810                 815     
Gln Ala Ile Ala Arg Ser Gln Pro Leu Ala Arg Gln Tyr Gln Ala Met 
            820                 825                 830         
Arg Gln Arg Thr Val Gln Leu Gln Ala Leu Cys Arg Gly Tyr Leu Val 
        835                 840                 845             
Arg Gln Gln Val Gln Ala Lys Arg Arg Ala Val Val Val Ile Gln Ala 
    850                 855                 860                 
His Ala Arg Gly Met Ala Ala Arg Arg Asn Phe Gln Gln Arg Lys Ala 
865                 870                 875                 880 
Asn Ala Pro Leu Val Ile Pro Ala Glu Gly Gln Lys Ser Gln Gly Ala 
                885                 890                 895     
Leu Pro Ala Lys Lys Arg Arg Ser Ile Tyr Asp Thr Val Thr Asp Thr 
            900                 905                 910         
Glu Met Val Glu Lys Val Phe Gly Phe Leu Pro Ala Met Ile Gly Gly 
        915                 920                 925             
Gln Glu Gly Gln Ala Ser Pro His Phe Glu Asp Leu Glu Ser Lys Thr 
    930                 935                 940                 
Gln Lys Leu Leu Glu Val Asp Leu Asp Thr Val Pro Met Ala Glu Glu 
945                 950                 955                 960 
Pro Glu Glu Asp Val Asp Gly Leu Ala Glu Tyr Thr Phe Pro Lys Phe 
                965                 970                 975     
Ala Val Thr Tyr Phe Gln Lys Ser Ala Ser His Thr His Ile Arg Arg 
            980                 985                 990         
Pro Leu Arg Tyr Pro Leu Leu Tyr His Glu Asp Asp Thr Asp Cys Leu 
        995                 1000                1005            
Ala Ala Leu Val Ile Trp Asn Val Ile Leu Arg Phe Met Gly Asp Leu 
    1010                1015                1020                
Pro Glu Pro Val Leu Tyr Ala Arg Ser Ser Gln Gln Gly Ser Ser Val 
1025                1030                1035                1040
Met Arg Gln Ile His Asp Thr Leu Gly Arg Glu His Gly Ala Gln Val 
                1045                1050                1055    
Pro Gln His Ser Arg Ser Ala Gln Val Ala Ser Gln Leu Asn Ile Gly 
            1060                1065                1070        
Glu Glu Ala Leu Glu Pro Asp Gly Leu Gly Ala Asp Arg Pro Met Ser 
        1075                1080                1085            
Asn Leu Glu Lys Val His Phe Ile Val Gly Tyr Ala Ile Leu Arg Pro 
    1090                1095                1100                
Ser Leu Arg Asp Glu Ile Tyr Cys Gln Ile Cys Lys Gln Leu Ser Glu 
1105                1110                1115                1120
Asn Phe Lys Thr Ser Ser Leu Ala Arg Gly Trp Ile Leu Leu Ser Leu 
                1125                1130                1135    
Cys Leu Gly Cys Phe Pro Pro Ser Glu Arg Phe Met Lys Tyr Leu Leu 
            1140                1145                1150        
Asn Phe Ile Gly Gln Gly Pro Ala Thr Tyr Gly Pro Phe Cys Ala Glu 
        1155                1160                1165            
Arg Leu Arg Arg Thr Tyr Ala Asn Gly Val Arg Ala Glu Pro Pro Thr 
    1170                1175                1180                
Trp Leu Glu Leu Gln Ala Val Lys Ser Lys Lys His Ile Pro Ile Gln 
1185                1190                1195                1200
Val Ile Leu Ala Thr Gly Glu Ser Leu Thr Val Pro Val Asp Ser Ala 
                1205                1210                1215    
Ser Thr Ser Arg Glu Met Cys Met His Ile Ala His Lys Gln Gly Leu 
            1220                1225                1230        
Ser Asp His Leu Gly Phe Ser Leu Gln Val Ala Val Tyr Asp Lys Phe 
        1235                1240                1245            
Trp Ser Leu Gly Ser Gly Arg Asp His Met Met Asp Ala Ile Ala Arg 
    1250                1255                1260                
Cys Glu Gln Met Ala Gln Glu Arg Gly Glu Ser Gln Arg Gln Ser Pro 
1265                1270                1275                1280
Trp Arg Ile Tyr Phe Arg Lys Glu Phe Phe Thr Pro Trp His Asp Ser 
                1285                1290                1295    
Arg Glu Asp Pro Val Ser Thr Glu Leu Ile Tyr Arg Gln Val Leu Arg 
            1300                1305                1310        
Gly Val Trp Ser Gly Glu Tyr Ser Phe Glu Lys Glu Glu Glu Leu Val 
        1315                1320                1325            
Glu Leu Leu Ala Arg His Cys Tyr Val Gln Leu Gly Ala Ser Ala Glu 
    1330                1335                1340                
Ser Lys Ala Val Gln Glu Leu Leu Pro Ser Cys Ile Pro His Lys Leu 
1345                1350                1355                1360
Tyr Arg Thr Lys Pro Pro Asp Arg Trp Ala Ser Leu Val Thr Ala Ala 
                1365                1370                1375    
Cys Ala Lys Ala Pro Tyr Thr Gln Lys Gln Val Thr Pro Leu Ala Val 
            1380                1385                1390        
Arg Glu Gln Val Val Asp Ala Ala Arg Leu Gln Trp Pro Leu Leu Phe 
        1395                1400                1405            
Ser Arg Leu Phe Glu Val Ile Thr Leu Ser Gly Pro Arg Leu Pro Lys 
    1410                1415                1420                
Thr Gln Leu Ile Leu Ala Val Asn Trp Lys Gly Leu Cys Phe Leu Asp 
1425                1430                1435                1440
Gln Gln Glu Lys Met Leu Leu Glu Leu Ser Phe Pro Glu Val Met Gly 
                1445                1450                1455    
Leu Ala Thr Asn Arg Glu Ala Gln Gly Gly Gln Arg Leu Leu Leu Ser 
            1460                1465                1470        
Thr Met His Glu Glu Tyr Glu Phe Val Ser Pro Ser Ser Val Ala Ile 
        1475                1480                1485            
Ala Glu Leu Val Ala Leu Phe Leu Glu Gly Leu Lys Glu Arg Ser Ile 
    1490                1495                1500                
Phe Ala Met Ala Leu Gln Asp Arg Lys Ala Thr Asp Asp Thr Thr Leu 
1505                1510                1515                1520
Leu Ala Phe Lys Lys Gly Asp Leu Leu Val Leu Thr Lys Lys Gln Gly 
                1525                1530                1535    
Leu Leu Ala Ser Glu Asn Trp Thr Leu Gly Gln Asn Asp Arg Thr Gly 
            1540                1545                1550        
Lys Thr Gly Leu Val Pro Met Ala Cys Leu Tyr Thr Ile Pro Thr Val 
        1555                1560                1565            
Thr Lys Pro Ser Ala Gln Leu Leu Ser Leu Leu Ala Met Ser Pro Glu 
    1570                1575                1580                
Lys Arg Lys Leu Ala Ala Gln Glu Gly Gln Phe Thr Glu Pro Arg Pro 
1585                1590                1595                1600
Glu Glu Pro Pro Lys Glu Lys Leu His Thr Leu Glu Glu Phe Ser Tyr 
                1605                1610                1615    
Glu Phe Phe Arg Ala Pro Glu Lys Asp Met Val Ser Met Ala Val Leu 
            1620                1625                1630        
Pro Leu Ala Arg Ala Arg Gly His Leu Trp Ala Tyr Ser Cys Glu Pro 
        1635                1640                1645            
Leu Arg Gln Pro Leu Leu Lys Arg Val His Ala Asn Val Asp Leu Trp 
    1650                1655                1660                
Asp Ile Ala Cys Gln Ile Phe Val Ala Ile Leu Arg Tyr Met Gly Asp 
1665                1670                1675                1680
Tyr Pro Ser Arg Gln Ala Trp Pro Thr Leu Glu Leu Thr Asp Gln Ile 
                1685                1690                1695    
Phe Thr Leu Ala Leu Gln His Pro Ala Leu Gln Asp Glu Val Tyr Cys 
            1700                1705                1710        
Gln Ile Leu Lys Gln Leu Thr His Asn Ser Asn Arg His Ser Glu Glu 
        1715                1720                1725            
Arg Gly Trp Gln Leu Leu Trp Leu Cys Thr Gly Leu Phe Pro Pro Ser 
    1730                1735                1740                
Lys Gly Leu Leu Pro His Ala Gln Lys Phe Ile Asp Thr Arg Arg Gly 
1745                1750                1755                1760
Lys Leu Leu Ala Pro Asp Cys Ser Arg Arg Ile Gln Lys Val Leu Arg 
                1765                1770                1775    
Thr Gly Pro Arg Lys Gln Pro Pro His Gln Val Glu Val Glu Ala Ala 
            1780                1785                1790        
Glu Gln Asn Val Ser Arg Ile Cys His Lys Ile Tyr Phe Pro Asn Asp 
        1795                1800                1805            
Thr Ser Glu Met Leu Glu Val Val Ala Asn Thr Arg Val Arg Asp Val 
    1810                1815                1820                
Cys Asp Ser Ile Ala Thr Arg Leu Gln Leu Ala Ser Trp Glu Gly Cys 
1825                1830                1835                1840
Ser Leu Phe Ile Lys Ile Ser Asp Lys Val Ile Ser Gln Lys Glu Gly 
                1845                1850                1855    
Asp Phe Phe Phe Asp Ser Leu Arg Glu Val Ser Asp Trp Val Lys Lys 
            1860                1865                1870        
Asn Lys Pro Gln Lys Glu Gly Ala Pro Val Thr Leu Pro Tyr Gln Val 
        1875                1880                1885            
Tyr Phe Met Arg Lys Leu Trp Leu Asn Ile Ser Pro Gly Lys Asp Val 
    1890                1895                1900                
Asn Ala Asp Thr Ile Leu His Tyr His Gln Glu Leu Pro Lys Tyr Leu 
1905                1910                1915                1920
Arg Gly Phe His Lys Cys Ser Arg Glu Asp Ala Ile His Leu Ala Gly 
                1925                1930                1935    
Leu Ile Tyr Lys Ala Gln Phe Asn Asn Asp Arg Ser Gln Leu Ala Ser 
            1940                1945                1950        
Val Pro Lys Ile Leu Arg Glu Leu Val Pro Glu Asn Leu Thr Arg Leu 
        1955                1960                1965            
Met Ser Ser Glu Glu Trp Lys Lys Ser Ile Leu Leu Ala Tyr Asp Lys 
    1970                1975                1980                
His Lys Asp Lys Thr Val Glu Glu Ala Lys Val Ala Phe Leu Lys Trp 
1985                1990                1995                2000
Ile Cys Arg Trp Pro Thr Phe Gly Ser Ala Phe Phe Glu Val Lys Gln 
                2005                2010                2015    
Thr Ser Glu Pro Ser Tyr Pro Asp Val Ile Leu Ile Ala Ile Asn Arg 
            2020                2025                2030        
His Gly Val Leu Leu Ile His Pro Lys Thr Lys Asp Leu Leu Thr Thr 
        2035                2040                2045            
Tyr Pro Phe Thr Lys Ile Ser Ser Trp Ser Ser Gly Ser Thr Tyr Phe 
    2050                2055                2060                
His Met Ala Leu Gly Ser Leu Gly Arg Gly Ser Arg Leu Leu Cys Glu 
2065                2070                2075                2080
Thr Ser Leu Gly Tyr Lys Met Asp Asp Leu Leu Thr Ser Tyr Val Gln 
                2085                2090                2095    
Gln Leu Leu Ser Ala Met Asn Lys Gln Arg Gly Ser Lys Ala Pro Ala 
            2100                2105                2110        
Leu Ala Ser Thr 
        2115    

<210> 35
<211> 6177
<212> DNA
<213> Homo sapiens


<400> 35
atggataact tcttcaccga gggaacacgg gtctggctga gagaaaatgg ccagcatttt       60

ccaagtactg taaattcctg tgcagaaggc atcgtcgtct tccggacaga ctatggtcag      120

gtattcactt acaagcagag cacaattacc caccagaagg tgactgctat gcaccccacg      180

aacgaggagg gcgtggatga catggcgtcc ttgacagagc tccatggcgg ctccatcatg      240

tataacttat tccagcggta taagagaaat caaatatata cctacatcgg ctccatcctg      300

gcctccgtga acccctacca gcccatcgcc gggctgtacg agcctgccac catggagcag      360

tacagccggc gccacctggg cgagctgccc ccgcacatct tcgccatcgc caacgagtgc      420

taccgctgcc tgtggaagcg ccacgacaac cagtgcatcc tcatcagtgg tgaaagtggg      480

gcaggtaaaa ccgaaagcac taaattgatc ctcaagtttc tgtcagtcat cagtcaacag      540

tctttggaat tgtccttaaa ggagaagaca tcctgtgttg aacgagctat tcttgaaagc      600

agccccatca tggaagcttt cggcaatgcg aagaccgtgt acaacaacaa ctctagtcgc      660

tttgggaagt ttgttcagct gaacatctgt cagaaaggaa atattcaggg cgggagaatt      720

gtagattatt tattagaaaa aaaccgagta gtaaggcaaa atcccgggga aaggaattat      780

cacatatttt atgcactgct ggcagggctg gaacatgaag aaagagaaga attttattta      840

tctacgccag aaaactacca ctacttgaat cagtctggat gtgtagaaga caagacaatc      900

agtgaccagg aatcctttag ggaagttatt acggcaatgg acgtgatgca gttcagcaag      960

gaggaagttc gggaagtgtc gaggctgctt gctggtatac tgcatcttgg gaacatagaa     1020

tttatcactg ctggtggggc acaggtttcc ttcaaaacag ctttgggcag atctgcggag     1080

ttacttgggc tggacccaac acagctcaca gatgctttga cccagagatc aatgttcctc     1140

aggggagaag agatcctcac gcctctcaat gttcaacagg cagtagacag cagggactcc     1200

ctggccatgg ctctgtatgc gtgctgcttt gagtgggtaa tcaagaagat caacagcagg     1260

atcaaaggca atgaggactt caagtctatt ggcatcctcg acatctttgg atttgaaaac     1320

tttgaggtta atcactttga acagttcaat ataaactatg caaacgagaa acttcaggag     1380

tacttcaaca agcatatttt ttctttagaa caactagaat atagccggga aggattagtg     1440

tgggaagata ttgactggat agacaatgga gaatgcctgg acttgattga gaagaaactt     1500

ggcctcctag cccttatcaa tgaagaaagc cattttcctc aagccacaga cagcacctta     1560

ttggagaagc tacacagtca gcatgcgaat aaccactttt atgtgaagcc cagagttgca     1620

gttaacaatt ttggagtgaa gcactatgct ggagaggtgc aatatgatgt ccgaggtatc     1680

ttggagaaga acagagatac atttcgagat gaccttctca atttgctaag agaaagccga     1740

tttgacttta tctacgatct ttttgaacat gtttcaagcc gcaacaacca ggataccttg     1800

aaatgtggaa gcaaacatcg gcggcctaca gtcagctcac agttcaagga ctcactgcat     1860

tccttaatgg caacgctaag ctcctctaat cctttctttg ttcgctgtat caagccaaac     1920

atgcagaaga tgccagacca gtttgaccag gcggttgtgc tgaaccagct gcggtactca     1980

gggatgctgg agactgtgag aatccgcaaa gctgggtatg cggtccgaag accctttcag     2040

gacttttaca aaaggtataa agtgctgatg aggaatctgg ctctgcctga ggacgtccga     2100

gggaagtgca cgagcctgct gcagctctat gatgcctcca acagcgagtg gcagctgggg     2160

aagaccaagg tctttcttcg agaatccttg gaacagaaac tggagaagcg gagggaagag     2220

gaagtgagcc acgcggccat ggtgattcgg gcccatgtct tgggcttctt agcacgaaaa     2280

caatacagaa aggtccttta ttgtgtggtg ataatacaga agaattacag agcattcctt     2340

ctgaggagga gatttttgca cctgaaaaag gcagccatag ttttccagaa gcaactcaga     2400

ggtcagattg ctcggagagt ttacagacaa ttgctggcag agaaaaggga gcaagaagaa     2460

aagaagaaac aggaagagga agaaaagaag aaacgggagg aagaagaaag agaaagagag     2520

agagagcgaa gagaagccga gctccgcgcc cagcaggaag aagaaacgag gaagcagcaa     2580

gaactcgaag ccttgcagaa gagccagaag gaagctgaac tgacccgtga actggagaaa     2640

cagaaggaaa ataagcaggt ggaagagatc ctccgtctgg agaaagaaat cgaggacctg     2700

cagcgcatga aggagcagca ggagctgtcg ctgaccgagg cttccctgca gaagctgcag     2760

gagcggcggg accaggagct ccgcaggctg gaggaggaag cgtgcagggc ggcccaggag     2820

ttcctcgagt ccctcaattt cgacgagatc gacgagtgtg tccggaatat cgagcggtcc     2880

ctgtcggtgg gaagcgaatt ttccagcgag ctggctgaga gcgcatgcga ggagaagccc     2940

aacttcaact tcagccagcc ctacccagag gaggaggtcg atgagggctt cgaagccgac     3000

gacgacgcct tcaaggactc ccccaacccc agcgagcacg gccactcaga ccagcgaaca     3060

agtggcatcc ggaccagcga tgactcttca gaggaggacc catacatgaa cgacacggtg     3120

gtgcccacca gccccagtgc ggacagcacg gtgctgctcg ccccatcagt gcaggactcc     3180

gggagcctac acaactcctc cagcggcgag tccacctact gcatgcccca gaacgctggg     3240

gacttgccct ccccagacgg cgactacgac tacgaccagg atgactatga ggacggtgcc     3300

atcacttccg gcagcagcgt gaccttctcc aactcctacg gcagccagtg gtcccccgac     3360

taccgctgct ctgtggggac ctacaacagc tcgggtgcct accggttcag ctctgagggg     3420

gcgcagtcct cgtttgaaga tagtgaagag gactttgatt ccaggtttga tacagatgat     3480

gagctttcat accggcgtga ctctgtgtac agctgtgtca ctctgccgta tttccacagc     3540

tttctgtaca tgaaaggtgg cctgatgaac tcttggaaac gccgctggtg cgtcctcaag     3600

gatgaaacct tcttgtggtt ccgctccaag caggaggccc tcaagcaagg ctggctccac     3660

aaaaaagggg ggggctcctc cacgctgtcc aggagaaatt ggaagaagcg ctggtttgtc     3720

ctccgccagt ccaagctgat gtactttgaa aacgacagcg aggagaagct caagggcacc     3780

gtagaagtgc gaacggcaaa agagatcata gataacacca ccaaggagaa tgggatcgac     3840

atcattatgg ccgataggac tttccacctg attgcagagt ccccagaaga tgccagccag     3900

tggttcagcg tgctgagtca ggtccacgcg tccacggacc aggagatcca ggagatgcat     3960

gatgagcagg caaacccaca gaatgctgtg ggcaccttgg atgtggggct gattgattct     4020

gtgtgtgcct ctgacagccc tgatagaccc aactcgtttg tgatcatcac ggccaaccgg     4080

gtgctgcact gcaacgccga cacgccggag gagatgcacc actggataac cctgctgcag     4140

aggtccaaag gggacaccag agtggagggc caggaattca tcgtgagagg atggttgcac     4200

aaagaggtga agaacagtcc aaagatgtct tcactgaaac tgaagaaacg gtggtttgta     4260

ctcacccaca attccctgga ttactacaag agttcagaga agaacgcgct caaactgggg     4320

accctggtcc tcaacagcct ctgctctgtc gtccccccag atgagaagat attcaaagag     4380

acaggctact ggaacgtcac cgtgtacggg cgcaagcact gttaccggct ctacaccaag     4440

ctgctcaacg aggccacccg gtggtccagt gccattcaaa acgtgactga caccaaggcc     4500

ccgatcgaca cccccaccca gcagctgatt caagatatca aggagaactg cctgaactcg     4560

gatgtggtgg aacagattta caagcggaac ccgatccttc gatacaccca tcaccccttg     4620

cactccccgc tcctgcccct tccgtatggg gacataaatc tcaacttgct caaagacaaa     4680

ggctatacca cccttcagga tgaggccatc aagatattca attccctgca gcaactggag     4740

tccatgtctg acccaattcc aataatccag ggcatcctac agacagggca tgacctgcga     4800

cctctgcggg acgagctgta ctgccagctt atcaaacaga ccaacaaagt gccccacccc     4860

ggcagtgtgg gcaacctgta cagctggcag atcctgacat gcctgagctg caccttcctg     4920

ccgagtcgag ggattctcaa gtatctcaag ttccatctga aaaggatacg ggaacagttt     4980

ccaggaagcg agatggaaaa atacgctctc ttcacttacg aatctcttaa gaaaaccaaa     5040

tgccgagagt ttgtgccttc ccgagatgaa atagaagctc tgatccacag gcaggaaatg     5100

acatccacgg tctattgcca tggcggcggc tcctgcaaga tcaccatcaa ctcccacacc     5160

accgctgggg aggtggtgga gaagctgatc cgaggcctgg ccatggagga cagcaggaac     5220

atgtttgctt tgtttgaata caacggccac gtcgacaaag ccattgaaag tcgaaccgtc     5280

gtagctgatg tcttagccaa gtttgaaaag ctggctgcca catccgaggt tggggacctg     5340

ccatggaaat tctacttcaa actttactgc ttcctggaca cagacaacgt gccaaaagac     5400

agtgtggagt ttgcatttat gtttgaacag gcccacgaag cggttatcca tggccaccat     5460

ccagccccgg aagaaaacct ccaggttctt gctgccctgc gactccagta tctgcagggg     5520

gattatactc tgcacgctgc catcccacct ctcgaagagg tttattccct gcagagactc     5580

aaggcccgca tcagccagtc aaccaaaacc ttcacccctt gtgaacggct ggagaagagg     5640

cggacgagct tcctagaggg gaccctgagg cggagcttcc ggacaggatc cgtggtccgg     5700

cagaaggtcg aggaggagca gatgctggac atgtggatta aggaagaagt ctcctctgct     5760

cgagccagta tcattgacaa gtggaggaaa tttcagggaa tgaaccagga acaggccatg     5820

gccaagtaca tggccttgat caaggagtgg cctggctatg gctcgacgct gtttgatgtg     5880

gagtgcaagg aaggtggctt ccctcaggaa ctctggttgg gtgtcagcgc ggacgccgtc     5940

tccgtctaca agcgtggaga gggaagacca ctggaagtct tccagtatga acacatcctc     6000

tcttttgggg cacccctggc gaatacgtat aagatcgtgg tcgatgagag ggagctgctc     6060

tttgaaacca gtgaggtggt ggatgtggcc aagctcatga aagcctacat cagcatgatc     6120

gtgaagaagc gctacagcac gacacgctcc gccagcagcc agggcagctc caggtga        6177


<210> 36
<211> 2058
<212> PRT
<213> Homo sapiens


<400> 36
Met Asp Asn Phe Phe Thr Glu Gly Thr Arg Val Trp Leu Arg Glu Asn 
1               5                   10                  15      
Gly Gln His Phe Pro Ser Thr Val Asn Ser Cys Ala Glu Gly Ile Val 
            20                  25                  30          
Val Phe Arg Thr Asp Tyr Gly Gln Val Phe Thr Tyr Lys Gln Ser Thr 
        35                  40                  45              
Ile Thr His Gln Lys Val Thr Ala Met His Pro Thr Asn Glu Glu Gly 
    50                  55                  60                  
Val Asp Asp Met Ala Ser Leu Thr Glu Leu His Gly Gly Ser Ile Met 
65                  70                  75                  80  
Tyr Asn Leu Phe Gln Arg Tyr Lys Arg Asn Gln Ile Tyr Thr Tyr Ile 
                85                  90                  95      
Gly Ser Ile Leu Ala Ser Val Asn Pro Tyr Gln Pro Ile Ala Gly Leu 
            100                 105                 110         
Tyr Glu Pro Ala Thr Met Glu Gln Tyr Ser Arg Arg His Leu Gly Glu 
        115                 120                 125             
Leu Pro Pro His Ile Phe Ala Ile Ala Asn Glu Cys Tyr Arg Cys Leu 
    130                 135                 140                 
Trp Lys Arg His Asp Asn Gln Cys Ile Leu Ile Ser Gly Glu Ser Gly 
145                 150                 155                 160 
Ala Gly Lys Thr Glu Ser Thr Lys Leu Ile Leu Lys Phe Leu Ser Val 
                165                 170                 175     
Ile Ser Gln Gln Ser Leu Glu Leu Ser Leu Lys Glu Lys Thr Ser Cys 
            180                 185                 190         
Val Glu Arg Ala Ile Leu Glu Ser Ser Pro Ile Met Glu Ala Phe Gly 
        195                 200                 205             
Asn Ala Lys Thr Val Tyr Asn Asn Asn Ser Ser Arg Phe Gly Lys Phe 
    210                 215                 220                 
Val Gln Leu Asn Ile Cys Gln Lys Gly Asn Ile Gln Gly Gly Arg Ile 
225                 230                 235                 240 
Val Asp Tyr Leu Leu Glu Lys Asn Arg Val Val Arg Gln Asn Pro Gly 
                245                 250                 255     
Glu Arg Asn Tyr His Ile Phe Tyr Ala Leu Leu Ala Gly Leu Glu His 
            260                 265                 270         
Glu Glu Arg Glu Glu Phe Tyr Leu Ser Thr Pro Glu Asn Tyr His Tyr 
        275                 280                 285             
Leu Asn Gln Ser Gly Cys Val Glu Asp Lys Thr Ile Ser Asp Gln Glu 
    290                 295                 300                 
Ser Phe Arg Glu Val Ile Thr Ala Met Asp Val Met Gln Phe Ser Lys 
305                 310                 315                 320 
Glu Glu Val Arg Glu Val Ser Arg Leu Leu Ala Gly Ile Leu His Leu 
                325                 330                 335     
Gly Asn Ile Glu Phe Ile Thr Ala Gly Gly Ala Gln Val Ser Phe Lys 
            340                 345                 350         
Thr Ala Leu Gly Arg Ser Ala Glu Leu Leu Gly Leu Asp Pro Thr Gln 
        355                 360                 365             
Leu Thr Asp Ala Leu Thr Gln Arg Ser Met Phe Leu Arg Gly Glu Glu 
    370                 375                 380                 
Ile Leu Thr Pro Leu Asn Val Gln Gln Ala Val Asp Ser Arg Asp Ser 
385                 390                 395                 400 
Leu Ala Met Ala Leu Tyr Ala Cys Cys Phe Glu Trp Val Ile Lys Lys 
                405                 410                 415     
Ile Asn Ser Arg Ile Lys Gly Asn Glu Asp Phe Lys Ser Ile Gly Ile 
            420                 425                 430         
Leu Asp Ile Phe Gly Phe Glu Asn Phe Glu Val Asn His Phe Glu Gln 
        435                 440                 445             
Phe Asn Ile Asn Tyr Ala Asn Glu Lys Leu Gln Glu Tyr Phe Asn Lys 
    450                 455                 460                 
His Ile Phe Ser Leu Glu Gln Leu Glu Tyr Ser Arg Glu Gly Leu Val 
465                 470                 475                 480 
Trp Glu Asp Ile Asp Trp Ile Asp Asn Gly Glu Cys Leu Asp Leu Ile 
                485                 490                 495     
Glu Lys Lys Leu Gly Leu Leu Ala Leu Ile Asn Glu Glu Ser His Phe 
            500                 505                 510         
Pro Gln Ala Thr Asp Ser Thr Leu Leu Glu Lys Leu His Ser Gln His 
        515                 520                 525             
Ala Asn Asn His Phe Tyr Val Lys Pro Arg Val Ala Val Asn Asn Phe 
    530                 535                 540                 
Gly Val Lys His Tyr Ala Gly Glu Val Gln Tyr Asp Val Arg Gly Ile 
545                 550                 555                 560 
Leu Glu Lys Asn Arg Asp Thr Phe Arg Asp Asp Leu Leu Asn Leu Leu 
                565                 570                 575     
Arg Glu Ser Arg Phe Asp Phe Ile Tyr Asp Leu Phe Glu His Val Ser 
            580                 585                 590         
Ser Arg Asn Asn Gln Asp Thr Leu Lys Cys Gly Ser Lys His Arg Arg 
        595                 600                 605             
Pro Thr Val Ser Ser Gln Phe Lys Asp Ser Leu His Ser Leu Met Ala 
    610                 615                 620                 
Thr Leu Ser Ser Ser Asn Pro Phe Phe Val Arg Cys Ile Lys Pro Asn 
625                 630                 635                 640 
Met Gln Lys Met Pro Asp Gln Phe Asp Gln Ala Val Val Leu Asn Gln 
                645                 650                 655     
Leu Arg Tyr Ser Gly Met Leu Glu Thr Val Arg Ile Arg Lys Ala Gly 
            660                 665                 670         
Tyr Ala Val Arg Arg Pro Phe Gln Asp Phe Tyr Lys Arg Tyr Lys Val 
        675                 680                 685             
Leu Met Arg Asn Leu Ala Leu Pro Glu Asp Val Arg Gly Lys Cys Thr 
    690                 695                 700                 
Ser Leu Leu Gln Leu Tyr Asp Ala Ser Asn Ser Glu Trp Gln Leu Gly 
705                 710                 715                 720 
Lys Thr Lys Val Phe Leu Arg Glu Ser Leu Glu Gln Lys Leu Glu Lys 
                725                 730                 735     
Arg Arg Glu Glu Glu Val Ser His Ala Ala Met Val Ile Arg Ala His 
            740                 745                 750         
Val Leu Gly Phe Leu Ala Arg Lys Gln Tyr Arg Lys Val Leu Tyr Cys 
        755                 760                 765             
Val Val Ile Ile Gln Lys Asn Tyr Arg Ala Phe Leu Leu Arg Arg Arg 
    770                 775                 780                 
Phe Leu His Leu Lys Lys Ala Ala Ile Val Phe Gln Lys Gln Leu Arg 
785                 790                 795                 800 
Gly Gln Ile Ala Arg Arg Val Tyr Arg Gln Leu Leu Ala Glu Lys Arg 
                805                 810                 815     
Glu Gln Glu Glu Lys Lys Lys Gln Glu Glu Glu Glu Lys Lys Lys Arg 
            820                 825                 830         
Glu Glu Glu Glu Arg Glu Arg Glu Arg Glu Arg Arg Glu Ala Glu Leu 
        835                 840                 845             
Arg Ala Gln Gln Glu Glu Glu Thr Arg Lys Gln Gln Glu Leu Glu Ala 
    850                 855                 860                 
Leu Gln Lys Ser Gln Lys Glu Ala Glu Leu Thr Arg Glu Leu Glu Lys 
865                 870                 875                 880 
Gln Lys Glu Asn Lys Gln Val Glu Glu Ile Leu Arg Leu Glu Lys Glu 
                885                 890                 895     
Ile Glu Asp Leu Gln Arg Met Lys Glu Gln Gln Glu Leu Ser Leu Thr 
            900                 905                 910         
Glu Ala Ser Leu Gln Lys Leu Gln Glu Arg Arg Asp Gln Glu Leu Arg 
        915                 920                 925             
Arg Leu Glu Glu Glu Ala Cys Arg Ala Ala Gln Glu Phe Leu Glu Ser 
    930                 935                 940                 
Leu Asn Phe Asp Glu Ile Asp Glu Cys Val Arg Asn Ile Glu Arg Ser 
945                 950                 955                 960 
Leu Ser Val Gly Ser Glu Phe Ser Ser Glu Leu Ala Glu Ser Ala Cys 
                965                 970                 975     
Glu Glu Lys Pro Asn Phe Asn Phe Ser Gln Pro Tyr Pro Glu Glu Glu 
            980                 985                 990         
Val Asp Glu Gly Phe Glu Ala Asp Asp Asp Ala Phe Lys Asp Ser Pro 
        995                 1000                1005            
Asn Pro Ser Glu His Gly His Ser Asp Gln Arg Thr Ser Gly Ile Arg 
    1010                1015                1020                
Thr Ser Asp Asp Ser Ser Glu Glu Asp Pro Tyr Met Asn Asp Thr Val 
1025                1030                1035                1040
Val Pro Thr Ser Pro Ser Ala Asp Ser Thr Val Leu Leu Ala Pro Ser 
                1045                1050                1055    
Val Gln Asp Ser Gly Ser Leu His Asn Ser Ser Ser Gly Glu Ser Thr 
            1060                1065                1070        
Tyr Cys Met Pro Gln Asn Ala Gly Asp Leu Pro Ser Pro Asp Gly Asp 
        1075                1080                1085            
Tyr Asp Tyr Asp Gln Asp Asp Tyr Glu Asp Gly Ala Ile Thr Ser Gly 
    1090                1095                1100                
Ser Ser Val Thr Phe Ser Asn Ser Tyr Gly Ser Gln Trp Ser Pro Asp 
1105                1110                1115                1120
Tyr Arg Cys Ser Val Gly Thr Tyr Asn Ser Ser Gly Ala Tyr Arg Phe 
                1125                1130                1135    
Ser Ser Glu Gly Ala Gln Ser Ser Phe Glu Asp Ser Glu Glu Asp Phe 
            1140                1145                1150        
Asp Ser Arg Phe Asp Thr Asp Asp Glu Leu Ser Tyr Arg Arg Asp Ser 
        1155                1160                1165            
Val Tyr Ser Cys Val Thr Leu Pro Tyr Phe His Ser Phe Leu Tyr Met 
    1170                1175                1180                
Lys Gly Gly Leu Met Asn Ser Trp Lys Arg Arg Trp Cys Val Leu Lys 
1185                1190                1195                1200
Asp Glu Thr Phe Leu Trp Phe Arg Ser Lys Gln Glu Ala Leu Lys Gln 
                1205                1210                1215    
Gly Trp Leu His Lys Lys Gly Gly Gly Ser Ser Thr Leu Ser Arg Arg 
            1220                1225                1230        
Asn Trp Lys Lys Arg Trp Phe Val Leu Arg Gln Ser Lys Leu Met Tyr 
        1235                1240                1245            
Phe Glu Asn Asp Ser Glu Glu Lys Leu Lys Gly Thr Val Glu Val Arg 
    1250                1255                1260                
Thr Ala Lys Glu Ile Ile Asp Asn Thr Thr Lys Glu Asn Gly Ile Asp 
1265                1270                1275                1280
Ile Ile Met Ala Asp Arg Thr Phe His Leu Ile Ala Glu Ser Pro Glu 
                1285                1290                1295    
Asp Ala Ser Gln Trp Phe Ser Val Leu Ser Gln Val His Ala Ser Thr 
            1300                1305                1310        
Asp Gln Glu Ile Gln Glu Met His Asp Glu Gln Ala Asn Pro Gln Asn 
        1315                1320                1325            
Ala Val Gly Thr Leu Asp Val Gly Leu Ile Asp Ser Val Cys Ala Ser 
    1330                1335                1340                
Asp Ser Pro Asp Arg Pro Asn Ser Phe Val Ile Ile Thr Ala Asn Arg 
1345                1350                1355                1360
Val Leu His Cys Asn Ala Asp Thr Pro Glu Glu Met His His Trp Ile 
                1365                1370                1375    
Thr Leu Leu Gln Arg Ser Lys Gly Asp Thr Arg Val Glu Gly Gln Glu 
            1380                1385                1390        
Phe Ile Val Arg Gly Trp Leu His Lys Glu Val Lys Asn Ser Pro Lys 
        1395                1400                1405            
Met Ser Ser Leu Lys Leu Lys Lys Arg Trp Phe Val Leu Thr His Asn 
    1410                1415                1420                
Ser Leu Asp Tyr Tyr Lys Ser Ser Glu Lys Asn Ala Leu Lys Leu Gly 
1425                1430                1435                1440
Thr Leu Val Leu Asn Ser Leu Cys Ser Val Val Pro Pro Asp Glu Lys 
                1445                1450                1455    
Ile Phe Lys Glu Thr Gly Tyr Trp Asn Val Thr Val Tyr Gly Arg Lys 
            1460                1465                1470        
His Cys Tyr Arg Leu Tyr Thr Lys Leu Leu Asn Glu Ala Thr Arg Trp 
        1475                1480                1485            
Ser Ser Ala Ile Gln Asn Val Thr Asp Thr Lys Ala Pro Ile Asp Thr 
    1490                1495                1500                
Pro Thr Gln Gln Leu Ile Gln Asp Ile Lys Glu Asn Cys Leu Asn Ser 
1505                1510                1515                1520
Asp Val Val Glu Gln Ile Tyr Lys Arg Asn Pro Ile Leu Arg Tyr Thr 
                1525                1530                1535    
His His Pro Leu His Ser Pro Leu Leu Pro Leu Pro Tyr Gly Asp Ile 
            1540                1545                1550        
Asn Leu Asn Leu Leu Lys Asp Lys Gly Tyr Thr Thr Leu Gln Asp Glu 
        1555                1560                1565            
Ala Ile Lys Ile Phe Asn Ser Leu Gln Gln Leu Glu Ser Met Ser Asp 
    1570                1575                1580                
Pro Ile Pro Ile Ile Gln Gly Ile Leu Gln Thr Gly His Asp Leu Arg 
1585                1590                1595                1600
Pro Leu Arg Asp Glu Leu Tyr Cys Gln Leu Ile Lys Gln Thr Asn Lys 
                1605                1610                1615    
Val Pro His Pro Gly Ser Val Gly Asn Leu Tyr Ser Trp Gln Ile Leu 
            1620                1625                1630        
Thr Cys Leu Ser Cys Thr Phe Leu Pro Ser Arg Gly Ile Leu Lys Tyr 
        1635                1640                1645            
Leu Lys Phe His Leu Lys Arg Ile Arg Glu Gln Phe Pro Gly Ser Glu 
    1650                1655                1660                
Met Glu Lys Tyr Ala Leu Phe Thr Tyr Glu Ser Leu Lys Lys Thr Lys 
1665                1670                1675                1680
Cys Arg Glu Phe Val Pro Ser Arg Asp Glu Ile Glu Ala Leu Ile His 
                1685                1690                1695    
Arg Gln Glu Met Thr Ser Thr Val Tyr Cys His Gly Gly Gly Ser Cys 
            1700                1705                1710        
Lys Ile Thr Ile Asn Ser His Thr Thr Ala Gly Glu Val Val Glu Lys 
        1715                1720                1725            
Leu Ile Arg Gly Leu Ala Met Glu Asp Ser Arg Asn Met Phe Ala Leu 
    1730                1735                1740                
Phe Glu Tyr Asn Gly His Val Asp Lys Ala Ile Glu Ser Arg Thr Val 
1745                1750                1755                1760
Val Ala Asp Val Leu Ala Lys Phe Glu Lys Leu Ala Ala Thr Ser Glu 
                1765                1770                1775    
Val Gly Asp Leu Pro Trp Lys Phe Tyr Phe Lys Leu Tyr Cys Phe Leu 
            1780                1785                1790        
Asp Thr Asp Asn Val Pro Lys Asp Ser Val Glu Phe Ala Phe Met Phe 
        1795                1800                1805            
Glu Gln Ala His Glu Ala Val Ile His Gly His His Pro Ala Pro Glu 
    1810                1815                1820                
Glu Asn Leu Gln Val Leu Ala Ala Leu Arg Leu Gln Tyr Leu Gln Gly 
1825                1830                1835                1840
Asp Tyr Thr Leu His Ala Ala Ile Pro Pro Leu Glu Glu Val Tyr Ser 
                1845                1850                1855    
Leu Gln Arg Leu Lys Ala Arg Ile Ser Gln Ser Thr Lys Thr Phe Thr 
            1860                1865                1870        
Pro Cys Glu Arg Leu Glu Lys Arg Arg Thr Ser Phe Leu Glu Gly Thr 
        1875                1880                1885            
Leu Arg Arg Ser Phe Arg Thr Gly Ser Val Val Arg Gln Lys Val Glu 
    1890                1895                1900                
Glu Glu Gln Met Leu Asp Met Trp Ile Lys Glu Glu Val Ser Ser Ala 
1905                1910                1915                1920
Arg Ala Ser Ile Ile Asp Lys Trp Arg Lys Phe Gln Gly Met Asn Gln 
                1925                1930                1935    
Glu Gln Ala Met Ala Lys Tyr Met Ala Leu Ile Lys Glu Trp Pro Gly 
            1940                1945                1950        
Tyr Gly Ser Thr Leu Phe Asp Val Glu Cys Lys Glu Gly Gly Phe Pro 
        1955                1960                1965            
Gln Glu Leu Trp Leu Gly Val Ser Ala Asp Ala Val Ser Val Tyr Lys 
    1970                1975                1980                
Arg Gly Glu Gly Arg Pro Leu Glu Val Phe Gln Tyr Glu His Ile Leu 
1985                1990                1995                2000
Ser Phe Gly Ala Pro Leu Ala Asn Thr Tyr Lys Ile Val Val Asp Glu 
                2005                2010                2015    
Arg Glu Leu Leu Phe Glu Thr Ser Glu Val Val Asp Val Ala Lys Leu 
            2020                2025                2030        
Met Lys Ala Tyr Ile Ser Met Ile Val Lys Lys Arg Tyr Ser Thr Thr 
        2035                2040                2045            
Arg Ser Ala Ser Ser Gln Gly Ser Ser Arg 
    2050                2055            

<210> 37
<211> 10593
<212> DNA
<213> Homo sapiens


<400> 37
atggcgaagg aggaagatga ggagaagaaa gccaagaaag ggaagaaggg gaagaaggca       60

ccggagccgg agaagcccaa acggagcctg aaggggacgt cgcggctgtt catgggcttc      120

cgcgaccgta cacccaagat ctccaagaag ggccagttcc gcagcgcctc ggccttcttc      180

tggggcctcc acaccggccc ccagaagacc aagcgcaaga ggaaggcccg caccgtgctc      240

aagtccacgt caaagctcat gacgcagatg cgcatgggca agaagaagcg ggcgatgaag      300

ggcaagaagc cgtccttcat ggtgatccgc ttcccaggcc gccgtggcta cggccgcctg      360

cggccgcgcg cccggtcact cagcaaagcg tccacggcca tcaactggct cacaaaaaag      420

ttcctcctca agaaggccga ggagtcgggc agcgaacagg ccacagtgga cgcctggctg      480

cagcgctcga gctcccgcat gggctcccgc aaactcccct tcccgtcggg tgccgagatc      540

ctgcggcctg ggggccggct ccggaggttc ccccgcagcc gcagcatcta cgcgtcaggc      600

gagcccctgg gcttcctgcc cttcgaggac gaggccccat tccatcactc gggctcccgc      660

aagtcgctgt acgggcttga gggcttccag gacctgggcg agtattatga ctatcaccgc      720

gacggcgacg actactacga ccggcagtca ctccaccgct acgaggagca ggaaccctac      780

ctggcgggcc tcggccccta cagcccggcc tggccaccct acggcgacca ctactacggg      840

tacccgcccg aggatcccta cgactactac caccccgact attacggtgg cccctttgat      900

ccggggtaca cctacggcta cggctacgac gattacgaac ccccatatgc gcccccgtcg      960

gggtactcgt ctccttacag ctaccacgat gggtacgagg gcgaggcgca cccttatggc     1020

tactacctgg atccctatgc gccgtacgac gcgccatacc caccctatga cctcccatac     1080

cacactccct acgatgtacc ctactttgat ccctacggag tccactacac cgtcccctat     1140

gccgaaggcg tctatggcgg tggggacgag gccatctacc cccccgaggt gccctatttt     1200

tacccggagg agtcggcttc ggcctttgtg tacccctggg taccaccgcc catcccgtcg     1260

ccccacaacc cgtatgccca cgccatggat gacatcgccg agctggagga accagaggac     1320

gcgggcgtag agcgtcaggg gacctccttc cgcctgccca gcgccgcctt cttcgagcag     1380

caaggcatgg ataagcccgc caggtccaag ctgtccctca tccgcaagtt ccgcctcttc     1440

ccgcgacccc aggtgaagct gtttgggaag gagaagctgg aggtgcccct gccaccctct     1500

ctggacattc ctctcccctt gggggatgcg gacgaagaag aggacgagga ggagctgccc     1560

ccggtttccg ctgtgcccta cggccaccct ttctggggct tcctcacgcc gcgccagcgc     1620

aacctccagc gcgcgctgtc ggccttcggc gcccaccggg gcctgggctt cggccctgag     1680

tttggccgcc ccgtgcctcg ccctgccacc tcgcttgcgc ggttcctcaa gaagacgctg     1740

tcggagaaga agcccatcgc gcggctcagg ggcagccaga aggcccgggc gggcggccct     1800

gctgtcaggg aggcggccta caaacgcttc ggctacaagc tggctggcat ggaccccgag     1860

aagcccggca cgcccatcgt gctgaggagg gcccagccac gcgctcgcag cagcaacgac     1920

gcgcgccgcc cgcccgcgcc acagcccgcg cccaggaccc tctcccactg gagcgcgctc     1980

ctgtctccgc ccgtgccccc gcggccccca agctccgggc ccccgcccgc gccgccgctc     2040

tccccggcgc tctcgggcct gccccggccg gcctcgccct acggctccct ccgccgccac     2100

ccgccgccct gggccgcccc agcgcacgtg ccaccggcgc cgcaggccag ctggtgggcc     2160

ttcgtggagc cccctgccgt gagcccggag gtgccccccg acctactagc cttcccaggg     2220

ccccgaccct cgttcagggg ctcccgccgg agaggggcgg ctttcggctt ccccggggcc     2280

tctccacggg cgtcgcggag gcgagcttgg tcaccgctgg cctcgcccca gccctcgctg     2340

aggagctcgc cgggcctcgg ctactgctca cccttggcgc ccccgtcgcc tcagctgtcc     2400

ttgcgcacgg gccccttcca gccgcccttc ctgcccccgg cccgccggcc ccgctcgctg     2460

caggagtccc cagccccacg ccgagccgct gggcgcctgg gcccacccgg ctcgccgctg     2520

ccgggctcac ccaggccgcc ctcgccgccc ctggggctct gccacagccc gcggcgcagc     2580

tccctgaatc tgccctcgcg cctcccgcac acgtggcggc gcctcagcga gccacccact     2640

cgggctgtga agccgcaagt gcgcctgccc ttccaccgac cgcccagggc cggggcctgg     2700

cgggcgcccc tggaacaccg ggagagcccg cgagaacccg aggactcaga gacgccctgg     2760

actgtgcccc cactggcccc cagctgggac gtggacatgc ctcccaccca acgcccaccc     2820

tccccctggc caggaggtgc aggcagccgc cgaggctttt ccaggccacc ccctgtgccg     2880

gaaaacccct ttctccagct cctgggccct gtgccatccc ccaccctcca gcctgaggat     2940

ccagctgctg atatgaccag ggtcttcctg ggcagacacc atgagccggg gcctggacag     3000

ctcaccaaat cagctggccc aacccctgag aagcctgaag aagaggccac cctgggggac     3060

ccccagctgc cagcagagac caagcctcca accccagcac ctcccaagga tgtcactccc     3120

cccaaggata tcactccccc caaggatgtc ctcccagagc aaaagacatt aaggcccagc     3180

ctctcatacc cactggctgc gtgtgaccag accagggcca catggccacc atggcaccgc     3240

tggggaacac tgccccaagc cgcagccccc ttggcgccca tcagggcccc agagcccctg     3300

cccaaggggg gtgaacggcg ccaggcagcc cctgggcgtt ttgctgtggt catgcctcgt     3360

gtgcagaagc tgagctcttt ccagcgagtt gggcctgcaa ccctgaagcc tcaagtccag     3420

cccattcagg accccaagcc aagagcctgt agtcttcgct ggtcctgcct ctggcttcgg     3480

gcagatgcct atggaccctg gccacgagta cacacccatc cccagtcctg ccacctgggc     3540

cctggagctg cctgcctgtc ccttaggggc tcctgggagg aggtcggccc gccaagctgg     3600

cggaacaaga tgcactccat ccgcaacctg ccatccatgc ggttccgtga gcagcacggg     3660

gaggatggtg tggaggacat gacacagctg gaagacctcc aggaaaccac tgtgctgtcc     3720

aacctcaaga ttagatttga acggaacctc atctacacat acattgggag catcctggtg     3780

tcggtgaacc cataccaaat gtttggaatc tatgggccgg agcaggtgca gcagtacaac     3840

ggacgggccc tgggagagaa tcccccgcac ctctttgctg ttgcaaatct cgccttcgcc     3900

aaaatgctcg atgccaaaca gaaccagtgc ataatcatta gtggagagag cggctctggc     3960

aaaactgagg ccaccaagct gattctgcgc tacctggccg ccatgaacca gaaacgggag     4020

gtcatgcagc agataaagat cctggaggca acacccctct tggagtcctt cggtaatgcc     4080

aaaaccgtca ggaacgacaa ctccagccgc tttgggaagt ttgtggaaat ctttctggaa     4140

gggggcgtga tctctggtgc cataacctcc cagtacctgc ttgagaaatc caggatcgtg     4200

tttcaggcca aaaacgagag gaattaccac atcttctacg agttgctggc cgggttgcct     4260

gcccagctca ggcaggcctt tagcctgcaa gaggctgaga cctactacta tctgaaccag     4320

ggtgggaact gtgagatagc aggaaagagc gatgcagatg actttcgccg gctcctggct     4380

gccatggagg tgttgggctt cagcagtgag gaccaggaca gcatcttccg catcctggcc     4440

tccatcctgc acctgggcaa cgtctacttt gagaagtatg agacggatgc acaggaggtg     4500

gcctcagtgg tgagtgcccg agagatccag gccgtggcag agctgctgca gatctcccct     4560

gagggcctgc agaaggccat caccttcaaa gtgaccgaga caatgcgaga gaagatcttc     4620

acgcccctaa ctgtggagag cgctgtggat gccagggacg ccatcgccaa ggtcttgtat     4680

gcactgctgt tcagctggct catcaccagg gtcaacgcgc tggtgtcccc aaggcaggac     4740

acactgtcca tcgccatcct ggacatctat ggtttcgagg acctgagctt caacagcttt     4800

gagcagctgt gtattaacta cgcaaacgag aaccttcagt accttttcaa caagatcgtc     4860

ttccaggagg agcaggagga gtacatccgt gagcagatag actggcagga gatcaccttt     4920

gctgacaacc agccctgcat caacctcatc tcactgaagc cttatggcat cctgcggatc     4980

cttgacgacc agtgttgctt tccccaggct acagaccaca ccttcctaca gaagtgccac     5040

taccatcatg gcgccaaccc gctctattcc aaacccaaga tgccgctgcc tgagttcacc     5100

atcaagcact atgcaggcaa ggtcacctac caggtgcaca agttcctgga caagaaccac     5160

gaccaagtgc gccaggatgt gctggacctg ttcgtacgga gccggacacg ggtggtggca     5220

cacctcttct ccagccatgc cccacaggct gcccctcagc gcctgggcaa gagcagctcc     5280

gtcactcggc tctacaaggc gcacactgtg gccgccaagt tccagcagtc actcctggat     5340

ctggtggaaa agatggagag gtgcaacccc ttgttcatgc gttgcctgaa gcccaaccac     5400

aagaaggagc caggtctctt tgagccagat gtggtaatgg cacaattacg ctattcaggg     5460

gtgctggaga ccgtgaggat ccgcaaggag ggatttccag tgcgcctgcc tttccagggg     5520

ttcatcgaca ggtactgctg tctagtggcc ctcaagcatg acctgccggc taatggggac     5580

atgtgtgtgt cagtgctgag tcgcctgtgc aaagtcatgc caaacatgta ccgtgttggg     5640

gtcagcaagc tgttccttaa ggaacaccta taccagctgc tggagagtat gcgagagcat     5700

gtcctgaatc tggcagccct cactctgcag cgctgcctcc gtggcttctt cattaagcgg     5760

cgattccgct ctctgcgcca caagatcatc ctgctgcaaa gccgggcccg tggctacctt     5820

gccaggcaac gctatcagca gatgaggagg agtctggtga agttccggtc cctggtacac     5880

gcatacgtga gccgccgacg ctatctcaag ctgagggcag agtggaggtg ccaggtggag     5940

ggggcgctgc tgtgggagca ggaggagctg agcaagcggg aggtagtcgc tgtggggcac     6000

ctggaggtac cggctgagct ggctgggctc ttgcaagcag tggcaggcct cgggctggcc     6060

caggtgcctc aggtggcccc tgtgaggact cctcgactcc aggctgagcc ccgtgtcaca     6120

ctgcccctgg acatcaacaa ctatcctatg gccaagtttg tccagtgcca cttcaaggaa     6180

cctgcctttg ggatgctgac agtgcccctg aggacacccc tcacgcagct gccagccgag     6240

caccatgcag aagccgtgag catcttcaag ctgatcctgc gcttcatggg cgacccccac     6300

ctgcatggtg cccgggagaa catcttcggg aactacatcg tgcagaaggg gctggcggtg     6360

cctgagctgc gggatgagat cctggcacag ctggccaatc aggtgtggca caatcacaat     6420

gcccacaatg ctgagcgggg ctggctgctg ctggccgcct gcctcagtgg ctttgcacct     6480

tccccgtgct tcaacaagta ccttctcaag tttgtgtctg attatgggcg gaatggcttc     6540

caggctgtgt gtcagcaccg cctcatgcag gccatgggcc gggcccaaca gcagggctcg     6600

ggggctgccc gcaccttacc cccgacccag ctcgagtgga cagcgaccta tgagaaggcc     6660

agcatggcgc tggacgtggg ctgcttcaat ggtgaccagt tctcctgccc ggtgcactcc     6720

tggagtacgg gggaagaggt ggctggagac attctgaggc acagggggct ggcagatggc     6780

tggcgcggct ggaccgtggc catgaagaat ggtgtccagt gggcagagct ggctggccac     6840

gactacgtgt tagacctggt gtcggacctg gagctgctca gggacttccc tcgacagaag     6900

tcctacttca ttgtgggcac agaggggcct gcagccagca ggggaggccc caaagtggtg     6960

tttgggaaca gctgggactc ggatgaggac atgtccacta gaccccagcc ccaggagcac     7020

atgcccaaag tacttgactc tgatgggtac agcagccaca atcaggacgg tacaaatggg     7080

gagactgagg cccaaagagg gacagcaacc caccaagagt cagacagtct tggagagcct     7140

gctgtgcccc acaaggggct ggactgctac ctggatagcc tctttgaccc tgtgctgtcc     7200

tacggggatg cggacctgga gaagccaaca gccattgcct accgcatgaa agggggaggc     7260

cagcccggtg gaggcagcag tagtggtact gaagacaccc ccaggagacc cccagagcca     7320

aagccaatcc caggcctgga tgcctccaca ttggctctgc agcaagcctt catccacaaa     7380

caggccgtgc tgctggcccg ggagatgacc ctgcaggcca cggcactcca gcagcagccc     7440

ctgagtgctg ccctgagatc cttgcccgca gagaaacccc cagcaccaga ggcacagccg     7500

acgtctgtag gcaccggtcc ccctgccaaa cccgtgctcc tgcgtgccac tccaaagccc     7560

ttggccccag cccctctggc caaggctcca aggctcccca tcaagcctgt ggctgcccct     7620

gttctagctc aggatcaggc ttctccagaa accacttcac cctccccaga gctggtccgg     7680

tactctacgc tcaactctga gcacttccca cagcccacac agcagatcaa gaatattgtc     7740

aggcagtacc agcagccgtt ccggggaggc cggcctgagg ccctcaggaa ggatggcggg     7800

aaagtgttca tgaagcggcc agaccctcat gaggaggccc tgatgatcct gaaagggcag     7860

atgacccacc tggcagctgc acctggcacc caggtgtcca gagaggccgt ggccctggtg     7920

aagccggtga ccagtgcacc aaggccatcc atggcaccca cttcagctct gccctcgcga     7980

tcgctggagc cccctgagga actcacgcag acgcggctgc accgcctcat caatcccaac     8040

ttctacggct atcaggacgc cccctggaag atcttcctgc gcaaagaggt gttttacccc     8100

aaggacagct acagccatcc tgtgcagctt gacctcctgt tccggcagat cctgcacgac     8160

acgctctccg aggcctgcct tcgcatctct gaggatgaga ggctcaggat gaaggccttg     8220

tttgcccaga accagctgga cacacagaag cctctggtaa cggaaagcgt gaagcgggcc     8280

gtggtcagca ctgcacgaga cacctgggag gtctacttct cccgcatctt ccccgccacg     8340

ggcagcgtgg gcactggtgt gcagctccta gctgtgtccc acgtgggcat caaactcctg     8400

aggatggtca agggtggcca ggaggccggc gggcagctgc gggtcctgcg tgcatacagc     8460

tttgcagata tcctgtttgt gaccatgccc tcccagaaca tgctggagtt caacctggcc     8520

agtgagaagg tcatcctctt ctcagcccga gcgcaccagg tcaagaccct ggtagatgac     8580

ttcatcttgg agctgaagaa ggactctgac tacgtggtcg ctgtgaggaa cttcctgcct     8640

gaggaccctg cgctgctggc tttccacaag ggtgacatca tacacctgca gcccctagag     8700

ccacctcgag tgggctacag tgctggctgc gtggttcgca ggaaggtggt gtacctggag     8760

gagctgcgac gtagaggccc cgactttggc tggaggttcg ggaccatcca cgggcgcgtg     8820

ggccgcttcc cttcggagct ggtgcagccc gctgctgccc ccgacttcct gcagctgcca     8880

acggagccag gccgcggccg agcagccgcc gtggccgctg ctgtggcctc tgcagccgct     8940

gcacaggagg tgggccgcag gagagagggt cccccagtca gggcccgctc tgctgaccat     9000

ggggaggacg ccctggcgct cccaccctac acaatgctcg agtttgccca gaagtatttc     9060

cgagaccctc agaggagacc ccaggatggc ctcaggctga aatccaagga gcctcgggag     9120

tccagaacct tggaggacat gctttgcttc accaagactc ccctccagga atccctcatc     9180

gaactcagcg acagcagcct cagcaagatg gccaccgaca tgttcctagc tgtaatgagg     9240

ttcatggggg atgccccact gaagggccag agtgacctgg acgtgctttg taacctcctg     9300

aagctgtgcg gggaccatga ggtcatgcgg gatgaatgtt actgccaagt tgtgaagcag     9360

atcacagaca ataccagctc caagcaggac agctgccagc gaggctggag gctgctgtat     9420

atcgtgaccg cctaccacag ctgctctgag gtcctccacc cacacctcac tcgcttcctc     9480

caagacgtga gccggacccc aggcctgccc tttcagggga tcgccaaggc ctgcgagcag     9540

aacctgcaga aaaccttgcg cttcggaggt cgtctggagc tccccagcag catagagctt     9600

cgggccatgt tggcaggccg cagttccaag aggcaactct ttcttcttcc tggaggcctt     9660

gaacgccatc tcaaaatcaa aacatgcact gtggccctgg acgtggtgga agagatatgt     9720

gctgagatgg ctctgacacg ccctgaggcc ttcaatgaat atgttatctt cgttgtcacc     9780

aaccgtggcc agcatgtgtg cccactcagt cgccgtgctt acatcctgga tgtggcctca     9840

gagatggagc aggtggacgg cggctacatg ctctggttcc ggcgtgtgct ctgggatcag     9900

ccactcaagt tcgagaatga gctatatgtg accatgcact acaaccaggt cctgcctgac     9960

tacctgaagg gactcttcag cagtgtgccg gccagccggc ccagcgagca gctgctgcag    10020

caggtgtcca agctggcttc actgcagcat cgcgccaagg accacttcta cctgccgagc    10080

gtgcgggaag tccaggagta catcccagcc cagctctacc gtacaacggc aggctcgacc    10140

tggctcaacc tggtcagcca gcaccggcag cagacacagg cgctcagccc ccaccaggcc    10200

cgtgcccagt ttctgggcct cctcagcgcc ttacctatgt tcggctcctc cttcttcttc    10260

atccagagct gcagcaacat tgctgtgcca gccccttgca tccttgccat caaccacaat    10320

ggcctcaact ttctcagcac agagactcat gaattgatgg tgaagttccc cctgaaggag    10380

atccagtcga cgcggaccca gcggcccacg gccaactcca gctaccccta tgtggagatt    10440

gcgctggggg acgtggcggc ccagcgcacc ttgcagctgc agctggagca gggactggaa    10500

ctgtgtcgtg tggtggccgt gcacgtggag aacctgctca gtgcccatga gaagcggctc    10560

acattgcccc ccagcgagat caccctgctc tga                                 10593


<210> 38
<211> 3530
<212> PRT
<213> Homo sapiens


<400> 38
Met Ala Lys Glu Glu Asp Glu Glu Lys Lys Ala Lys Lys Gly Lys Lys 
1               5                   10                  15      
Gly Lys Lys Ala Pro Glu Pro Glu Lys Pro Lys Arg Ser Leu Lys Gly 
            20                  25                  30          
Thr Ser Arg Leu Phe Met Gly Phe Arg Asp Arg Thr Pro Lys Ile Ser 
        35                  40                  45              
Lys Lys Gly Gln Phe Arg Ser Ala Ser Ala Phe Phe Trp Gly Leu His 
    50                  55                  60                  
Thr Gly Pro Gln Lys Thr Lys Arg Lys Arg Lys Ala Arg Thr Val Leu 
65                  70                  75                  80  
Lys Ser Thr Ser Lys Leu Met Thr Gln Met Arg Met Gly Lys Lys Lys 
                85                  90                  95      
Arg Ala Met Lys Gly Lys Lys Pro Ser Phe Met Val Ile Arg Phe Pro 
            100                 105                 110         
Gly Arg Arg Gly Tyr Gly Arg Leu Arg Pro Arg Ala Arg Ser Leu Ser 
        115                 120                 125             
Lys Ala Ser Thr Ala Ile Asn Trp Leu Thr Lys Lys Phe Leu Leu Lys 
    130                 135                 140                 
Lys Ala Glu Glu Ser Gly Ser Glu Gln Ala Thr Val Asp Ala Trp Leu 
145                 150                 155                 160 
Gln Arg Ser Ser Ser Arg Met Gly Ser Arg Lys Leu Pro Phe Pro Ser 
                165                 170                 175     
Gly Ala Glu Ile Leu Arg Pro Gly Gly Arg Leu Arg Arg Phe Pro Arg 
            180                 185                 190         
Ser Arg Ser Ile Tyr Ala Ser Gly Glu Pro Leu Gly Phe Leu Pro Phe 
        195                 200                 205             
Glu Asp Glu Ala Pro Phe His His Ser Gly Ser Arg Lys Ser Leu Tyr 
    210                 215                 220                 
Gly Leu Glu Gly Phe Gln Asp Leu Gly Glu Tyr Tyr Asp Tyr His Arg 
225                 230                 235                 240 
Asp Gly Asp Asp Tyr Tyr Asp Arg Gln Ser Leu His Arg Tyr Glu Glu 
                245                 250                 255     
Gln Glu Pro Tyr Leu Ala Gly Leu Gly Pro Tyr Ser Pro Ala Trp Pro 
            260                 265                 270         
Pro Tyr Gly Asp His Tyr Tyr Gly Tyr Pro Pro Glu Asp Pro Tyr Asp 
        275                 280                 285             
Tyr Tyr His Pro Asp Tyr Tyr Gly Gly Pro Phe Asp Pro Gly Tyr Thr 
    290                 295                 300                 
Tyr Gly Tyr Gly Tyr Asp Asp Tyr Glu Pro Pro Tyr Ala Pro Pro Ser 
305                 310                 315                 320 
Gly Tyr Ser Ser Pro Tyr Ser Tyr His Asp Gly Tyr Glu Gly Glu Ala 
                325                 330                 335     
His Pro Tyr Gly Tyr Tyr Leu Asp Pro Tyr Ala Pro Tyr Asp Ala Pro 
            340                 345                 350         
Tyr Pro Pro Tyr Asp Leu Pro Tyr His Thr Pro Tyr Asp Val Pro Tyr 
        355                 360                 365             
Phe Asp Pro Tyr Gly Val His Tyr Thr Val Pro Tyr Ala Glu Gly Val 
    370                 375                 380                 
Tyr Gly Gly Gly Asp Glu Ala Ile Tyr Pro Pro Glu Val Pro Tyr Phe 
385                 390                 395                 400 
Tyr Pro Glu Glu Ser Ala Ser Ala Phe Val Tyr Pro Trp Val Pro Pro 
                405                 410                 415     
Pro Ile Pro Ser Pro His Asn Pro Tyr Ala His Ala Met Asp Asp Ile 
            420                 425                 430         
Ala Glu Leu Glu Glu Pro Glu Asp Ala Gly Val Glu Arg Gln Gly Thr 
        435                 440                 445             
Ser Phe Arg Leu Pro Ser Ala Ala Phe Phe Glu Gln Gln Gly Met Asp 
    450                 455                 460                 
Lys Pro Ala Arg Ser Lys Leu Ser Leu Ile Arg Lys Phe Arg Leu Phe 
465                 470                 475                 480 
Pro Arg Pro Gln Val Lys Leu Phe Gly Lys Glu Lys Leu Glu Val Pro 
                485                 490                 495     
Leu Pro Pro Ser Leu Asp Ile Pro Leu Pro Leu Gly Asp Ala Asp Glu 
            500                 505                 510         
Glu Glu Asp Glu Glu Glu Leu Pro Pro Val Ser Ala Val Pro Tyr Gly 
        515                 520                 525             
His Pro Phe Trp Gly Phe Leu Thr Pro Arg Gln Arg Asn Leu Gln Arg 
    530                 535                 540                 
Ala Leu Ser Ala Phe Gly Ala His Arg Gly Leu Gly Phe Gly Pro Glu 
545                 550                 555                 560 
Phe Gly Arg Pro Val Pro Arg Pro Ala Thr Ser Leu Ala Arg Phe Leu 
                565                 570                 575     
Lys Lys Thr Leu Ser Glu Lys Lys Pro Ile Ala Arg Leu Arg Gly Ser 
            580                 585                 590         
Gln Lys Ala Arg Ala Gly Gly Pro Ala Val Arg Glu Ala Ala Tyr Lys 
        595                 600                 605             
Arg Phe Gly Tyr Lys Leu Ala Gly Met Asp Pro Glu Lys Pro Gly Thr 
    610                 615                 620                 
Pro Ile Val Leu Arg Arg Ala Gln Pro Arg Ala Arg Ser Ser Asn Asp 
625                 630                 635                 640 
Ala Arg Arg Pro Pro Ala Pro Gln Pro Ala Pro Arg Thr Leu Ser His 
                645                 650                 655     
Trp Ser Ala Leu Leu Ser Pro Pro Val Pro Pro Arg Pro Pro Ser Ser 
            660                 665                 670         
Gly Pro Pro Pro Ala Pro Pro Leu Ser Pro Ala Leu Ser Gly Leu Pro 
        675                 680                 685             
Arg Pro Ala Ser Pro Tyr Gly Ser Leu Arg Arg His Pro Pro Pro Trp 
    690                 695                 700                 
Ala Ala Pro Ala His Val Pro Pro Ala Pro Gln Ala Ser Trp Trp Ala 
705                 710                 715                 720 
Phe Val Glu Pro Pro Ala Val Ser Pro Glu Val Pro Pro Asp Leu Leu 
                725                 730                 735     
Ala Phe Pro Gly Pro Arg Pro Ser Phe Arg Gly Ser Arg Arg Arg Gly 
            740                 745                 750         
Ala Ala Phe Gly Phe Pro Gly Ala Ser Pro Arg Ala Ser Arg Arg Arg 
        755                 760                 765             
Ala Trp Ser Pro Leu Ala Ser Pro Gln Pro Ser Leu Arg Ser Ser Pro 
    770                 775                 780                 
Gly Leu Gly Tyr Cys Ser Pro Leu Ala Pro Pro Ser Pro Gln Leu Ser 
785                 790                 795                 800 
Leu Arg Thr Gly Pro Phe Gln Pro Pro Phe Leu Pro Pro Ala Arg Arg 
                805                 810                 815     
Pro Arg Ser Leu Gln Glu Ser Pro Ala Pro Arg Arg Ala Ala Gly Arg 
            820                 825                 830         
Leu Gly Pro Pro Gly Ser Pro Leu Pro Gly Ser Pro Arg Pro Pro Ser 
        835                 840                 845             
Pro Pro Leu Gly Leu Cys His Ser Pro Arg Arg Ser Ser Leu Asn Leu 
    850                 855                 860                 
Pro Ser Arg Leu Pro His Thr Trp Arg Arg Leu Ser Glu Pro Pro Thr 
865                 870                 875                 880 
Arg Ala Val Lys Pro Gln Val Arg Leu Pro Phe His Arg Pro Pro Arg 
                885                 890                 895     
Ala Gly Ala Trp Arg Ala Pro Leu Glu His Arg Glu Ser Pro Arg Glu 
            900                 905                 910         
Pro Glu Asp Ser Glu Thr Pro Trp Thr Val Pro Pro Leu Ala Pro Ser 
        915                 920                 925             
Trp Asp Val Asp Met Pro Pro Thr Gln Arg Pro Pro Ser Pro Trp Pro 
    930                 935                 940                 
Gly Gly Ala Gly Ser Arg Arg Gly Phe Ser Arg Pro Pro Pro Val Pro 
945                 950                 955                 960 
Glu Asn Pro Phe Leu Gln Leu Leu Gly Pro Val Pro Ser Pro Thr Leu 
                965                 970                 975     
Gln Pro Glu Asp Pro Ala Ala Asp Met Thr Arg Val Phe Leu Gly Arg 
            980                 985                 990         
His His Glu Pro Gly Pro Gly Gln Leu Thr Lys Ser Ala Gly Pro Thr 
        995                 1000                1005            
Pro Glu Lys Pro Glu Glu Glu Ala Thr Leu Gly Asp Pro Gln Leu Pro 
    1010                1015                1020                
Ala Glu Thr Lys Pro Pro Thr Pro Ala Pro Pro Lys Asp Val Thr Pro 
1025                1030                1035                1040
Pro Lys Asp Ile Thr Pro Pro Lys Asp Val Leu Pro Glu Gln Lys Thr 
                1045                1050                1055    
Leu Arg Pro Ser Leu Ser Tyr Pro Leu Ala Ala Cys Asp Gln Thr Arg 
            1060                1065                1070        
Ala Thr Trp Pro Pro Trp His Arg Trp Gly Thr Leu Pro Gln Ala Ala 
        1075                1080                1085            
Ala Pro Leu Ala Pro Ile Arg Ala Pro Glu Pro Leu Pro Lys Gly Gly 
    1090                1095                1100                
Glu Arg Arg Gln Ala Ala Pro Gly Arg Phe Ala Val Val Met Pro Arg 
1105                1110                1115                1120
Val Gln Lys Leu Ser Ser Phe Gln Arg Val Gly Pro Ala Thr Leu Lys 
                1125                1130                1135    
Pro Gln Val Gln Pro Ile Gln Asp Pro Lys Pro Arg Ala Cys Ser Leu 
            1140                1145                1150        
Arg Trp Ser Cys Leu Trp Leu Arg Ala Asp Ala Tyr Gly Pro Trp Pro 
        1155                1160                1165            
Arg Val His Thr His Pro Gln Ser Cys His Leu Gly Pro Gly Ala Ala 
    1170                1175                1180                
Cys Leu Ser Leu Arg Gly Ser Trp Glu Glu Val Gly Pro Pro Ser Trp 
1185                1190                1195                1200
Arg Asn Lys Met His Ser Ile Arg Asn Leu Pro Ser Met Arg Phe Arg 
                1205                1210                1215    
Glu Gln His Gly Glu Asp Gly Val Glu Asp Met Thr Gln Leu Glu Asp 
            1220                1225                1230        
Leu Gln Glu Thr Thr Val Leu Ser Asn Leu Lys Ile Arg Phe Glu Arg 
        1235                1240                1245            
Asn Leu Ile Tyr Thr Tyr Ile Gly Ser Ile Leu Val Ser Val Asn Pro 
    1250                1255                1260                
Tyr Gln Met Phe Gly Ile Tyr Gly Pro Glu Gln Val Gln Gln Tyr Asn 
1265                1270                1275                1280
Gly Arg Ala Leu Gly Glu Asn Pro Pro His Leu Phe Ala Val Ala Asn 
                1285                1290                1295    
Leu Ala Phe Ala Lys Met Leu Asp Ala Lys Gln Asn Gln Cys Ile Ile 
            1300                1305                1310        
Ile Ser Gly Glu Ser Gly Ser Gly Lys Thr Glu Ala Thr Lys Leu Ile 
        1315                1320                1325            
Leu Arg Tyr Leu Ala Ala Met Asn Gln Lys Arg Glu Val Met Gln Gln 
    1330                1335                1340                
Ile Lys Ile Leu Glu Ala Thr Pro Leu Leu Glu Ser Phe Gly Asn Ala 
1345                1350                1355                1360
Lys Thr Val Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Phe Val Glu 
                1365                1370                1375    
Ile Phe Leu Glu Gly Gly Val Ile Ser Gly Ala Ile Thr Ser Gln Tyr 
            1380                1385                1390        
Leu Leu Glu Lys Ser Arg Ile Val Phe Gln Ala Lys Asn Glu Arg Asn 
        1395                1400                1405            
Tyr His Ile Phe Tyr Glu Leu Leu Ala Gly Leu Pro Ala Gln Leu Arg 
    1410                1415                1420                
Gln Ala Phe Ser Leu Gln Glu Ala Glu Thr Tyr Tyr Tyr Leu Asn Gln 
1425                1430                1435                1440
Gly Gly Asn Cys Glu Ile Ala Gly Lys Ser Asp Ala Asp Asp Phe Arg 
                1445                1450                1455    
Arg Leu Leu Ala Ala Met Glu Val Leu Gly Phe Ser Ser Glu Asp Gln 
            1460                1465                1470        
Asp Ser Ile Phe Arg Ile Leu Ala Ser Ile Leu His Leu Gly Asn Val 
        1475                1480                1485            
Tyr Phe Glu Lys Tyr Glu Thr Asp Ala Gln Glu Val Ala Ser Val Val 
    1490                1495                1500                
Ser Ala Arg Glu Ile Gln Ala Val Ala Glu Leu Leu Gln Ile Ser Pro 
1505                1510                1515                1520
Glu Gly Leu Gln Lys Ala Ile Thr Phe Lys Val Thr Glu Thr Met Arg 
                1525                1530                1535    
Glu Lys Ile Phe Thr Pro Leu Thr Val Glu Ser Ala Val Asp Ala Arg 
            1540                1545                1550        
Asp Ala Ile Ala Lys Val Leu Tyr Ala Leu Leu Phe Ser Trp Leu Ile 
        1555                1560                1565            
Thr Arg Val Asn Ala Leu Val Ser Pro Arg Gln Asp Thr Leu Ser Ile 
    1570                1575                1580                
Ala Ile Leu Asp Ile Tyr Gly Phe Glu Asp Leu Ser Phe Asn Ser Phe 
1585                1590                1595                1600
Glu Gln Leu Cys Ile Asn Tyr Ala Asn Glu Asn Leu Gln Tyr Leu Phe 
                1605                1610                1615    
Asn Lys Ile Val Phe Gln Glu Glu Gln Glu Glu Tyr Ile Arg Glu Gln 
            1620                1625                1630        
Ile Asp Trp Gln Glu Ile Thr Phe Ala Asp Asn Gln Pro Cys Ile Asn 
        1635                1640                1645            
Leu Ile Ser Leu Lys Pro Tyr Gly Ile Leu Arg Ile Leu Asp Asp Gln 
    1650                1655                1660                
Cys Cys Phe Pro Gln Ala Thr Asp His Thr Phe Leu Gln Lys Cys His 
1665                1670                1675                1680
Tyr His His Gly Ala Asn Pro Leu Tyr Ser Lys Pro Lys Met Pro Leu 
                1685                1690                1695    
Pro Glu Phe Thr Ile Lys His Tyr Ala Gly Lys Val Thr Tyr Gln Val 
            1700                1705                1710        
His Lys Phe Leu Asp Lys Asn His Asp Gln Val Arg Gln Asp Val Leu 
        1715                1720                1725            
Asp Leu Phe Val Arg Ser Arg Thr Arg Val Val Ala His Leu Phe Ser 
    1730                1735                1740                
Ser His Ala Pro Gln Ala Ala Pro Gln Arg Leu Gly Lys Ser Ser Ser 
1745                1750                1755                1760
Val Thr Arg Leu Tyr Lys Ala His Thr Val Ala Ala Lys Phe Gln Gln 
                1765                1770                1775    
Ser Leu Leu Asp Leu Val Glu Lys Met Glu Arg Cys Asn Pro Leu Phe 
            1780                1785                1790        
Met Arg Cys Leu Lys Pro Asn His Lys Lys Glu Pro Gly Leu Phe Glu 
        1795                1800                1805            
Pro Asp Val Val Met Ala Gln Leu Arg Tyr Ser Gly Val Leu Glu Thr 
    1810                1815                1820                
Val Arg Ile Arg Lys Glu Gly Phe Pro Val Arg Leu Pro Phe Gln Gly 
1825                1830                1835                1840
Phe Ile Asp Arg Tyr Cys Cys Leu Val Ala Leu Lys His Asp Leu Pro 
                1845                1850                1855    
Ala Asn Gly Asp Met Cys Val Ser Val Leu Ser Arg Leu Cys Lys Val 
            1860                1865                1870        
Met Pro Asn Met Tyr Arg Val Gly Val Ser Lys Leu Phe Leu Lys Glu 
        1875                1880                1885            
His Leu Tyr Gln Leu Leu Glu Ser Met Arg Glu His Val Leu Asn Leu 
    1890                1895                1900                
Ala Ala Leu Thr Leu Gln Arg Cys Leu Arg Gly Phe Phe Ile Lys Arg 
1905                1910                1915                1920
Arg Phe Arg Ser Leu Arg His Lys Ile Ile Leu Leu Gln Ser Arg Ala 
                1925                1930                1935    
Arg Gly Tyr Leu Ala Arg Gln Arg Tyr Gln Gln Met Arg Arg Ser Leu 
            1940                1945                1950        
Val Lys Phe Arg Ser Leu Val His Ala Tyr Val Ser Arg Arg Arg Tyr 
        1955                1960                1965            
Leu Lys Leu Arg Ala Glu Trp Arg Cys Gln Val Glu Gly Ala Leu Leu 
    1970                1975                1980                
Trp Glu Gln Glu Glu Leu Ser Lys Arg Glu Val Val Ala Val Gly His 
1985                1990                1995                2000
Leu Glu Val Pro Ala Glu Leu Ala Gly Leu Leu Gln Ala Val Ala Gly 
                2005                2010                2015    
Leu Gly Leu Ala Gln Val Pro Gln Val Ala Pro Val Arg Thr Pro Arg 
            2020                2025                2030        
Leu Gln Ala Glu Pro Arg Val Thr Leu Pro Leu Asp Ile Asn Asn Tyr 
        2035                2040                2045            
Pro Met Ala Lys Phe Val Gln Cys His Phe Lys Glu Pro Ala Phe Gly 
    2050                2055                2060                
Met Leu Thr Val Pro Leu Arg Thr Pro Leu Thr Gln Leu Pro Ala Glu 
2065                2070                2075                2080
His His Ala Glu Ala Val Ser Ile Phe Lys Leu Ile Leu Arg Phe Met 
                2085                2090                2095    
Gly Asp Pro His Leu His Gly Ala Arg Glu Asn Ile Phe Gly Asn Tyr 
            2100                2105                2110        
Ile Val Gln Lys Gly Leu Ala Val Pro Glu Leu Arg Asp Glu Ile Leu 
        2115                2120                2125            
Ala Gln Leu Ala Asn Gln Val Trp His Asn His Asn Ala His Asn Ala 
    2130                2135                2140                
Glu Arg Gly Trp Leu Leu Leu Ala Ala Cys Leu Ser Gly Phe Ala Pro 
2145                2150                2155                2160
Ser Pro Cys Phe Asn Lys Tyr Leu Leu Lys Phe Val Ser Asp Tyr Gly 
                2165                2170                2175    
Arg Asn Gly Phe Gln Ala Val Cys Gln His Arg Leu Met Gln Ala Met 
            2180                2185                2190        
Gly Arg Ala Gln Gln Gln Gly Ser Gly Ala Ala Arg Thr Leu Pro Pro 
        2195                2200                2205            
Thr Gln Leu Glu Trp Thr Ala Thr Tyr Glu Lys Ala Ser Met Ala Leu 
    2210                2215                2220                
Asp Val Gly Cys Phe Asn Gly Asp Gln Phe Ser Cys Pro Val His Ser 
2225                2230                2235                2240
Trp Ser Thr Gly Glu Glu Val Ala Gly Asp Ile Leu Arg His Arg Gly 
                2245                2250                2255    
Leu Ala Asp Gly Trp Arg Gly Trp Thr Val Ala Met Lys Asn Gly Val 
            2260                2265                2270        
Gln Trp Ala Glu Leu Ala Gly His Asp Tyr Val Leu Asp Leu Val Ser 
        2275                2280                2285            
Asp Leu Glu Leu Leu Arg Asp Phe Pro Arg Gln Lys Ser Tyr Phe Ile 
    2290                2295                2300                
Val Gly Thr Glu Gly Pro Ala Ala Ser Arg Gly Gly Pro Lys Val Val 
2305                2310                2315                2320
Phe Gly Asn Ser Trp Asp Ser Asp Glu Asp Met Ser Thr Arg Pro Gln 
                2325                2330                2335    
Pro Gln Glu His Met Pro Lys Val Leu Asp Ser Asp Gly Tyr Ser Ser 
            2340                2345                2350        
His Asn Gln Asp Gly Thr Asn Gly Glu Thr Glu Ala Gln Arg Gly Thr 
        2355                2360                2365            
Ala Thr His Gln Glu Ser Asp Ser Leu Gly Glu Pro Ala Val Pro His 
    2370                2375                2380                
Lys Gly Leu Asp Cys Tyr Leu Asp Ser Leu Phe Asp Pro Val Leu Ser 
2385                2390                2395                2400
Tyr Gly Asp Ala Asp Leu Glu Lys Pro Thr Ala Ile Ala Tyr Arg Met 
                2405                2410                2415    
Lys Gly Gly Gly Gln Pro Gly Gly Gly Ser Ser Ser Gly Thr Glu Asp 
            2420                2425                2430        
Thr Pro Arg Arg Pro Pro Glu Pro Lys Pro Ile Pro Gly Leu Asp Ala 
        2435                2440                2445            
Ser Thr Leu Ala Leu Gln Gln Ala Phe Ile His Lys Gln Ala Val Leu 
    2450                2455                2460                
Leu Ala Arg Glu Met Thr Leu Gln Ala Thr Ala Leu Gln Gln Gln Pro 
2465                2470                2475                2480
Leu Ser Ala Ala Leu Arg Ser Leu Pro Ala Glu Lys Pro Pro Ala Pro 
                2485                2490                2495    
Glu Ala Gln Pro Thr Ser Val Gly Thr Gly Pro Pro Ala Lys Pro Val 
            2500                2505                2510        
Leu Leu Arg Ala Thr Pro Lys Pro Leu Ala Pro Ala Pro Leu Ala Lys 
        2515                2520                2525            
Ala Pro Arg Leu Pro Ile Lys Pro Val Ala Ala Pro Val Leu Ala Gln 
    2530                2535                2540                
Asp Gln Ala Ser Pro Glu Thr Thr Ser Pro Ser Pro Glu Leu Val Arg 
2545                2550                2555                2560
Tyr Ser Thr Leu Asn Ser Glu His Phe Pro Gln Pro Thr Gln Gln Ile 
                2565                2570                2575    
Lys Asn Ile Val Arg Gln Tyr Gln Gln Pro Phe Arg Gly Gly Arg Pro 
            2580                2585                2590        
Glu Ala Leu Arg Lys Asp Gly Gly Lys Val Phe Met Lys Arg Pro Asp 
        2595                2600                2605            
Pro His Glu Glu Ala Leu Met Ile Leu Lys Gly Gln Met Thr His Leu 
    2610                2615                2620                
Ala Ala Ala Pro Gly Thr Gln Val Ser Arg Glu Ala Val Ala Leu Val 
2625                2630                2635                2640
Lys Pro Val Thr Ser Ala Pro Arg Pro Ser Met Ala Pro Thr Ser Ala 
                2645                2650                2655    
Leu Pro Ser Arg Ser Leu Glu Pro Pro Glu Glu Leu Thr Gln Thr Arg 
            2660                2665                2670        
Leu His Arg Leu Ile Asn Pro Asn Phe Tyr Gly Tyr Gln Asp Ala Pro 
        2675                2680                2685            
Trp Lys Ile Phe Leu Arg Lys Glu Val Phe Tyr Pro Lys Asp Ser Tyr 
    2690                2695                2700                
Ser His Pro Val Gln Leu Asp Leu Leu Phe Arg Gln Ile Leu His Asp 
2705                2710                2715                2720
Thr Leu Ser Glu Ala Cys Leu Arg Ile Ser Glu Asp Glu Arg Leu Arg 
                2725                2730                2735    
Met Lys Ala Leu Phe Ala Gln Asn Gln Leu Asp Thr Gln Lys Pro Leu 
            2740                2745                2750        
Val Thr Glu Ser Val Lys Arg Ala Val Val Ser Thr Ala Arg Asp Thr 
        2755                2760                2765            
Trp Glu Val Tyr Phe Ser Arg Ile Phe Pro Ala Thr Gly Ser Val Gly 
    2770                2775                2780                
Thr Gly Val Gln Leu Leu Ala Val Ser His Val Gly Ile Lys Leu Leu 
2785                2790                2795                2800
Arg Met Val Lys Gly Gly Gln Glu Ala Gly Gly Gln Leu Arg Val Leu 
                2805                2810                2815    
Arg Ala Tyr Ser Phe Ala Asp Ile Leu Phe Val Thr Met Pro Ser Gln 
            2820                2825                2830        
Asn Met Leu Glu Phe Asn Leu Ala Ser Glu Lys Val Ile Leu Phe Ser 
        2835                2840                2845            
Ala Arg Ala His Gln Val Lys Thr Leu Val Asp Asp Phe Ile Leu Glu 
    2850                2855                2860                
Leu Lys Lys Asp Ser Asp Tyr Val Val Ala Val Arg Asn Phe Leu Pro 
2865                2870                2875                2880
Glu Asp Pro Ala Leu Leu Ala Phe His Lys Gly Asp Ile Ile His Leu 
                2885                2890                2895    
Gln Pro Leu Glu Pro Pro Arg Val Gly Tyr Ser Ala Gly Cys Val Val 
            2900                2905                2910        
Arg Arg Lys Val Val Tyr Leu Glu Glu Leu Arg Arg Arg Gly Pro Asp 
        2915                2920                2925            
Phe Gly Trp Arg Phe Gly Thr Ile His Gly Arg Val Gly Arg Phe Pro 
    2930                2935                2940                
Ser Glu Leu Val Gln Pro Ala Ala Ala Pro Asp Phe Leu Gln Leu Pro 
2945                2950                2955                2960
Thr Glu Pro Gly Arg Gly Arg Ala Ala Ala Val Ala Ala Ala Val Ala 
                2965                2970                2975    
Ser Ala Ala Ala Ala Gln Glu Val Gly Arg Arg Arg Glu Gly Pro Pro 
            2980                2985                2990        
Val Arg Ala Arg Ser Ala Asp His Gly Glu Asp Ala Leu Ala Leu Pro 
        2995                3000                3005            
Pro Tyr Thr Met Leu Glu Phe Ala Gln Lys Tyr Phe Arg Asp Pro Gln 
    3010                3015                3020                
Arg Arg Pro Gln Asp Gly Leu Arg Leu Lys Ser Lys Glu Pro Arg Glu 
3025                3030                3035                3040
Ser Arg Thr Leu Glu Asp Met Leu Cys Phe Thr Lys Thr Pro Leu Gln 
                3045                3050                3055    
Glu Ser Leu Ile Glu Leu Ser Asp Ser Ser Leu Ser Lys Met Ala Thr 
            3060                3065                3070        
Asp Met Phe Leu Ala Val Met Arg Phe Met Gly Asp Ala Pro Leu Lys 
        3075                3080                3085            
Gly Gln Ser Asp Leu Asp Val Leu Cys Asn Leu Leu Lys Leu Cys Gly 
    3090                3095                3100                
Asp His Glu Val Met Arg Asp Glu Cys Tyr Cys Gln Val Val Lys Gln 
3105                3110                3115                3120
Ile Thr Asp Asn Thr Ser Ser Lys Gln Asp Ser Cys Gln Arg Gly Trp 
                3125                3130                3135    
Arg Leu Leu Tyr Ile Val Thr Ala Tyr His Ser Cys Ser Glu Val Leu 
            3140                3145                3150        
His Pro His Leu Thr Arg Phe Leu Gln Asp Val Ser Arg Thr Pro Gly 
        3155                3160                3165            
Leu Pro Phe Gln Gly Ile Ala Lys Ala Cys Glu Gln Asn Leu Gln Lys 
    3170                3175                3180                
Thr Leu Arg Phe Gly Gly Arg Leu Glu Leu Pro Ser Ser Ile Glu Leu 
3185                3190                3195                3200
Arg Ala Met Leu Ala Gly Arg Ser Ser Lys Arg Gln Leu Phe Leu Leu 
                3205                3210                3215    
Pro Gly Gly Leu Glu Arg His Leu Lys Ile Lys Thr Cys Thr Val Ala 
            3220                3225                3230        
Leu Asp Val Val Glu Glu Ile Cys Ala Glu Met Ala Leu Thr Arg Pro 
        3235                3240                3245            
Glu Ala Phe Asn Glu Tyr Val Ile Phe Val Val Thr Asn Arg Gly Gln 
    3250                3255                3260                
His Val Cys Pro Leu Ser Arg Arg Ala Tyr Ile Leu Asp Val Ala Ser 
3265                3270                3275                3280
Glu Met Glu Gln Val Asp Gly Gly Tyr Met Leu Trp Phe Arg Arg Val 
                3285                3290                3295    
Leu Trp Asp Gln Pro Leu Lys Phe Glu Asn Glu Leu Tyr Val Thr Met 
            3300                3305                3310        
His Tyr Asn Gln Val Leu Pro Asp Tyr Leu Lys Gly Leu Phe Ser Ser 
        3315                3320                3325            
Val Pro Ala Ser Arg Pro Ser Glu Gln Leu Leu Gln Gln Val Ser Lys 
    3330                3335                3340                
Leu Ala Ser Leu Gln His Arg Ala Lys Asp His Phe Tyr Leu Pro Ser 
3345                3350                3355                3360
Val Arg Glu Val Gln Glu Tyr Ile Pro Ala Gln Leu Tyr Arg Thr Thr 
                3365                3370                3375    
Ala Gly Ser Thr Trp Leu Asn Leu Val Ser Gln His Arg Gln Gln Thr 
            3380                3385                3390        
Gln Ala Leu Ser Pro His Gln Ala Arg Ala Gln Phe Leu Gly Leu Leu 
        3395                3400                3405            
Ser Ala Leu Pro Met Phe Gly Ser Ser Phe Phe Phe Ile Gln Ser Cys 
    3410                3415                3420                
Ser Asn Ile Ala Val Pro Ala Pro Cys Ile Leu Ala Ile Asn His Asn 
3425                3430                3435                3440
Gly Leu Asn Phe Leu Ser Thr Glu Thr His Glu Leu Met Val Lys Phe 
                3445                3450                3455    
Pro Leu Lys Glu Ile Gln Ser Thr Arg Thr Gln Arg Pro Thr Ala Asn 
            3460                3465                3470        
Ser Ser Tyr Pro Tyr Val Glu Ile Ala Leu Gly Asp Val Ala Ala Gln 
        3475                3480                3485            
Arg Thr Leu Gln Leu Gln Leu Glu Gln Gly Leu Glu Leu Cys Arg Val 
    3490                3495                3500                
Val Ala Val His Val Glu Asn Leu Leu Ser Ala His Glu Lys Arg Leu 
3505                3510                3515                3520
Thr Leu Pro Pro Ser Glu Ile Thr Leu Leu 
                3525                3530

<210> 39
<211> 9177
<212> DNA
<213> Homo sapiens


<400> 39
atgggcagga accagcgcaa agcgccccag cgcctggaga ggcccgggag gccggcctca       60

ggggagcagg agtcggggtc ggccagcgcg gatggcgcgc ccagccggga acgccgttcc      120

gaccgcgggc aggcggacag ggcgaaaccg gcggccgagc ctgccaccgc cgggggccag      180

ggaacccctg gtggccgcag gaagcccact gcagagggga acggcggctg cagacgccca      240

ggggctgggc tgtccccgaa agcccaggag aggcaaagca acgcgcagcg tcagggacgc      300

gggcccaggg gcggccgcgg ggggcgcctg gaggagggaa gcctctccgg aggagaagag      360

ctgggcggcc gccgtaggag gaagcggaaa gataaggggc cctcggctcg gcggggccgc      420

cggacgccca ggagcctcaa tggggacacg tcgggtgggg acggaggcag ctcctgtccg      480

gacagcgaaa cccgcgaggc ccaggagagc ggcagccagc gcggcacagc ccgggagctg      540

cggcccacgc cggagcctac ggacatgggc tcggaaggga caaaaaccgg gccggagtca      600

gcgctggagc caagcagcga cggcctggac agcgactggc cccacgcaga tacccggggc      660

cgggaagggt cgtcggggac ggggcccctg ggagccagcg agcattccgg cggggactcc      720

gactcgagtc cgctggggac cggacctgga cggggctctc gggcagctat ggcctccagg      780

accttcgagg acagctcgcg ggctcctcgg gacactgggc cggccaagga cgcgagcgac      840

aaccgggcgc agcggggcgc cgagccagaa acaatgcagg cctcgacggc ccgggctccg      900

cgccaccagg tcggaaaggc ggtggggcag gtgccagcgg cggcaggcga gggcgaagcg      960

ggagccgcag caggagcggg gccggaggac ccagccccgc tggcggccct cctggtggtc     1020

cgcaggctcc tcgcgaggcc cccgccaggc gccgcttccc aggccgtggg cccccgccgc     1080

gctggcctca aggagcggct cctgagtgta gcgcgagccc tgggcctcct gcgctggctg     1140

cggcggcggc tgcggctgcg gcggcggccg ccagagggcg aggggcaggg taccgggcca     1200

cgggcgagcg aggggtgggg ccgccggaaa ccggacgagg ggcggggtca tgggagagga     1260

agcaaggggc ggggccgcgg gaaagcggat gaagggcggg gccacgagcg aggggacgag     1320

ggtcggggcc gcgggaaagc ggacgaaggg cggggccacg agcgagggta cgaggggcgg     1380

ggctgcggga aagcggacga ggggcggggt cacgagagag gtgacgaggg ccgggaccac     1440

cagagagggt acgaggggtg gggccgtgag cccgggctgc ggcaccgtct agcgttgcgc     1500

ctggctggct tagcagggct ggggggtatg ccgagggctt cccctggtgg ccgctccccg     1560

caggtcccga caagcccagt ccccggcgac ccttttgatc aggaggacga gactccagat     1620

cccaagttcg cggtcgtgtt ccccaggatc cacagggcag ggcgggcgtc gagcagccgc     1680

agctctgaag aagcgtccgc agatgccccc acgggggaag gccgaggttg gcctcgtgca     1740

ggggtggggg ggcacagtga ggggtgcagg acgagtgggg aaggggtgtc cgggcttcgt     1800

cgcggctccc tccttgcccc gactgcaccc gacgggcctt ccctcgacga gagcggctcc     1860

agcagtgagg cggagttgga gaccctcaat gacgagcccc cggtgcgctg ggcgcagggc     1920

tcaggccccc acgagggtcc taggcttggc gccgccgtgc tgctaccccg actctccttg     1980

gagacccgcc tgcagcagga gggagacccg ggcctccgtg ggtccctgag ggagctgtgg     2040

gaacccgagg atgaggacga ggcggtgctg gagagggacc tggagctgag cctccggccg     2100

ggcctggagg cgccaccctt ccccggtgcc aagggcagga gcctcggaga cggcctggaa     2160

gacatggagg acctggcgcg gttgcggctg gtgtgtgaca gctctgtgct gctgtgcctc     2220

aagaagagat ttcacctggg ccgtatctat acctttgggg ggcctgtctt gcttgttctg     2280

aacccccacc ggtccttgcc tcttttttca cctgaggtcc aggcaagcta ccaccccagg     2340

aaggccctca gcaccactcc acacatcttt gccatcgtgg catcagccta tgacctggct     2400

cagaatactg ggcaggaccc atgcatcctc ctgtgctcct cccactgcag tgggcacagt     2460

ggctcaggga agacggaagc cgccaaaaag atcatgcagt tcctaagcag cctggagcag     2520

gatcagacgg ggaaccgaga gtgtcaggtg gaggatatgc tgcctatact cagcagcttt     2580

ggccatgcca agaccatcct caatgccaat gccagccgct tcggccaggt cttctgcctc     2640

tacctacagc aaggggtcat cgtgggagcc tctgtgtctc attatctact tgagacctcc     2700

agggtggtgt ttcagggcca ggcctgcagg ctgcaaggca aggaggatgc ccaggacttt     2760

gaggggctgc tgaaggcact gcaggggctc ggcttgtgcc cagaggagtt gaatgccgtc     2820

tgggctgtgc tggccgccat cctgcagctg ggcaacatct gcttctcctc ctcagagcga     2880

gagtcccagg aggtggctgc tgtgtctagc tgggctgaga tccacacagc agcccgactg     2940

ctgcgggtac caccagagtg cctggagggg gctgtcacca ggagggtcac ggagacgccc     3000

tatggccagg tctcgcgatc cctgcccgtg gaaagtgcct ttgatgccag ggacgccctg     3060

gccaaggcac tgtattcccg cctcttccac cggcttctga ggagaaccaa tgcacggctg     3120

gcaccaccag gggagggagg cagcattggc accgtcactg tcgtggatgc ctacggcttt     3180

gaggccctgc gggtgaatgg cctggagcaa ctgtgcaaca acctcgccag cgagcgccta     3240

cagctcttct ccagccagat gctgctggcc caggaggagg aggagtgtcg gcgggagttg     3300

ctgtcctggg tgcctgtccc tcagcctccg agggagtcct gcctagacct cctggtagat     3360

cagccccaca gcctcctgag tatcctggac gcccagacat ggctgtccca ggccacggac     3420

cacaccttcc tccagaagag ccactatcac catggtgacc accccagcta tgccaagccc     3480

cggctgcccc tgcccgtgtt caccgtgcga cattatgcag ggactgtcac ctaccaggtt     3540

cacaagtttt taaacagaaa ccgggatcag ctggaccctg ctgtggtgga gatgcttggc     3600

cagagccagc tccagctggt gggcagcctg ttccaggagg cagagcccca gtccagggga     3660

gggcgaggca gacccacgct ggcctctcgc ttccagcagg ccctggagga cctcatagcc     3720

cggctgggca ggagccatgt ctatttcatc cagtgcctca cccctaaccc tggaaagctt     3780

ccaggcctct ttgacgtggg acatgtgaca gagcaactgc accaggcagc catactggag     3840

gccgtgggca cccgcagtgc caacttcccc gtgcgtgtgc cctttgaggc cttcctggcc     3900

agcttccagg ccctggggtc agaagggcag gaagacctct ctgaccggga gaagtgtggt     3960

gccgtcctga gccaggtgct gggggccgaa tcacctctct atcaccttgg agccaccaag     4020

gtcctgctgc aggagcaggg ctggcagcgg ctggaggagc tccgggacca gcagcgctcc     4080

caggccctgg tcgacctgca ccgcagcttc cacacctgca tctcccgcca gcgcgtcctg     4140

ccccggatgc aggctcgcat gcgtgggttc caggccagga agcggtacct ccggcggcgg     4200

gcagctttgg gacagctgaa caccatcctg ctggtggccc agcccctgct ccagaggcgg     4260

cagagactgc agcttgggcg ttggcagggc tggcatagca gcgaaagggc cttggagaga     4320

gtgccaagca tggagctggg gcgcttggag atcccggctg agctggccgt catgctgaag     4380

acggcggaaa gccatcggga cgccctggct gggagcatca ccgagtgcct gccgcctgag     4440

gttcctgccc ggcccagcct gactctccca gcagacattg acctgttccc tttctccagc     4500

ttcgtcgcca tcggctttca ggaaccgtcc ctgcccaggc cagggcagcc actggcgaag     4560

cccctaaccc agctggatgg agacaaccct cagcgtgccc tggacatcaa caaagtgatg     4620

ctgcggctcc tgggggacgg atccctggag tcctggcaga ggcagatcat gggcgcatac     4680

ctggtgcggc aggggcagtg ccggccaggg ctgcggaatg agctctttag ccagctggtg     4740

gcccagctat ggcagaaccc agatgaacag cagagccagc gtggctgggc cctcatggct     4800

gttttgctca gcgcctttcc cccactgcct gtcctacaga agccactgct caagttcgtg     4860

tctgaccagg cccccagggg catggcagcg ctgtgccagc acaagctgct gggggccttg     4920

gagcagtcgc agctggcctc gggggccact cgggcccacc ccccgaccca gctggagtgg     4980

ctggccggat ggcggcgggg ccgcatggcg ctggatgtgt tcaccttcag cgaggagtgc     5040

tactcggccg aggtggagtc ttggaccacc ggggagcagc tggctgggtg gatcctgcag     5100

agcagaggcc tggaggcgcc tccccggggc tggtctgtgt cactgcactc cagggacgca     5160

tggcaggact tggctggctg cgactttgtg ctggacctga tcagccagac tgaggacctg     5220

ggggacccag ctcgcccccg cagctacccc atcactcctc ttggctcagc cgaggccatt     5280

ccccttgccc ctggcattca ggccccctca ctgcccccag gaccccctcc aggtccagcc     5340

ccaacgctgc ccagcaggga ccacacaggg gaggtccaga ggtcagggag cctggacggc     5400

ttcctggacc agatcttcca gccagtgata tcctccggcc tcagcgatct ggaacaaagc     5460

tgggctctga gcagccgcat gaagggaggg ggcgccattg ggcccacaca gcagggctac     5520

cccatggtgt acccaggaat gattcagatg cctgcatacc agccaggcat ggtccctgca     5580

cccatgccca tgatgccagc aatgggcaca gtccctgcca tgccagccat ggtggtgccg     5640

ccgcagccac cgcttcccag cctggatgca gggcagctgg ccgtccagca gcagaacttt     5700

atccagcagc aggcgctaat cctggcccag cagatgacag cccaggccat gtccctgtcc     5760

ctggagcagc agatgcagca gcggcagcag caggctcggg cctccgaggc tgcgtcccag     5820

gcctcaccct cagccgtcac ctccaagccc aggaagcccc ccacaccccc ggagaagcca     5880

cagcgtgacc tgggatcaga gggtggctgc ctgagggaga cctccgagga ggctgaagac     5940

aggccctatc agcccaagag cttccagcag aaacggaact atttccagag gatggggcag     6000

ccacagatca cagtgaggac gatgaagccc ccggccaagg tccacatccc ccagggggaa     6060

gcgcaggagg aggaggagga ggaggaggag gaggaggagc aggaggagca agaagtggaa     6120

acaagagcag tgccgtcccc tcctcctccc cccatcgtga agaagccatt gaagcaaggt     6180

ggggccaaag ctccaaaaga ggctgaggct gagccagcca aggagacagc ggccaagggc     6240

catggccaag ggccagccca aggcaggggg actgtggtgc gcagctcaga ctccaagccc     6300

aagcggccac aacccagcag ggaaattggc aacatcatcc gcatgtacca gagccgcccg     6360

ggccccgtgc ctgtgcccgt gcagccatcc aggcctccca aagctttcct gaggaaaatc     6420

gaccccaagg acgaggctct ggccaagctg ggtatcaacg gtgcccactc gtccccgccg     6480

atgctgtccc ccagcccagg aaagggcccc ccgccagctg tggctcctcg acccaaggcc     6540

ccgctacagc ttgggccctc tagctccatc aaggaaaagc aggggcccct tctggacctg     6600

tttggccaga agctgcctat tgcccacaca cccccacctc caccagcgcc accactgcct     6660

ctgcccgagg acccagggac cctttcagca gagcgtcgtt gcttgacaca gcccgtggag     6720

gaccaggggg tctccaccca gctactcgcg ccctctggca gcgtgtgctt ctcctacacc     6780

ggcacgccct ggaagttgtt cctacgcaag gaggtgttct acccacggga gaacttcagc     6840

catccctact acctgaggct cctctgtgag cagatcctac gggacacctt ctccgagtcc     6900

tgtatccgga tttcccagaa tgagcggcgg aaaatgaaag acctgctggg aggcttggag     6960

gtggacctgg attctctcac caccaccgaa gacagcgtca agaagcgcat cgtggtggcc     7020

gctcgggaca actgggccaa ttacttctcc cgcttctttc ctgtctcggg cgagagtggc     7080

agcgacgtgc agctgttagc cgtgtcccac cgtgggctgc gactgctcaa ggtgacccaa     7140

ggccccggcc tccgccccga ccagctgaag attctctgct catacagctt tgcggaggtg     7200

ctgggtgtgg agtgccgggg cggctccacc ctggagctgt cactgaagag cgagcagctg     7260

gtgctgcaca cagcccgggc aagggccatc gaggcgctgg ttgagctatt cctgaatgag     7320

cttaagaagg actccggcta tgtcatcgcc ctgcgcagct acatcactga caactgcagc     7380

ctcctcagct tccaccgtgg ggacctcatc aagctgctgc cggtggccac cctggagcca     7440

ggctggcagt ttggctctgc cgggggccgt tccggactct ttcctgccga catagtgcag     7500

ccggctgccg ctcccgactt ttccttctcc aaggagcaga ggagtggctg gcacaagggt     7560

cagctgtcca acggggaacc agggctggct cggtgggaca gggcctcaga gcgccctgcc     7620

cacccttgga gccaggcaca cagtgacgac tcggaggcca ccagcctgtc ctctgtggcc     7680

tatgcctttc tgcccgactc ccacagctac accatgcagg aattcgcccg gcgttacttc     7740

cggaggtccc aggccttgct gggccagact gatggaggtg ccgcaggaaa ggacacggac     7800

agcctggtgc agtacaccaa ggctcccatc caggagtcgc tcctcagcct cagtgatgat     7860

gtgagcaagc tggctgtagc cagcttcctg gccctgatgc ggtttatggg tgaccagtcc     7920

aagccccggg gcaaggatga gatggatctg ctctatgaac tgctgaagct gtgccagcag     7980

gagaagctga gggatgagat ttactgccag gttatcaagc aggtcacggg acacccccgg     8040

ccggaacact gcactcgagg ctggagcttc ctcagccttc tcacaggctt cttccccccg     8100

tcgaccaggc tgatgcccta cctgaccaag tttctgcagg attcaggccc cagccaagag     8160

ctggcccgga gcagccagga gcacctccag cgcacagtca aatatggggg gcgccggcgg     8220

atgcccccac cgggtgaaat gaaggctttc ctgaaaggac aagcgattcg cctgcttctt     8280

attcacctgc cggggggtgt ggattatagg acgaatatcc agactttcac agtagcagca     8340

gaagtgcagg aggagctgtg ccggcaaatg ggtatcacgg agcctcagga agtgcaggaa     8400

ttcgccctct tcctcatcaa agagaagagc cagctggtgc ggcccctgca gcccgccgaa     8460

tacctcaaca gcgtggtagt ggaccaggac gtgagcctgc acagccggcg gctccactgg     8520

gagaccccac tgcacttcga taactccacc tacatcagca cccactacag ccaggtgctg     8580

tgggactacc ttcaggggaa gctgccagtc agcgccaagg cagacgcgca gctcgccagg     8640

ctggccgccc tgcagcacct cagcaaggcc aacaggaata ccccctcagg gcaggacctg     8700

ctagcttacg tgccaaagca gctgcaacgg caggtgaaca cggcctccat caagaacctg     8760

atgggtcagg agctgagacg gctggaagga cacagccccc aggaagcaca gatcagcttc     8820

attgaggcca tgagccagct gcccctcttc ggctacaccg tctatggggt gctgcgagtg     8880

agcatgcagg ccctgtccgg acccactctc ctggggctca accgccagca tctcatcctc     8940

atggacccca gctcccagag cctgtactgc cgcattgccc tgaagagcct gcagcggctc     9000

cacctgctaa gccctctgga ggagaagggg ccccctggcc tggaagtcaa ctatggctca     9060

gctgacaacc cccagaccat ctggtttgag ctgccacagg cccaggagct gctatacacc     9120

actgtcttcc tgatagacag cagtgcctct tgcactgagt ggcccagcat caactga        9177


<210> 40
<211> 3058
<212> PRT
<213> Homo sapiens


<400> 40
Met Gly Arg Asn Gln Arg Lys Ala Pro Gln Arg Leu Glu Arg Pro Gly 
1               5                   10                  15      
Arg Pro Ala Ser Gly Glu Gln Glu Ser Gly Ser Ala Ser Ala Asp Gly 
            20                  25                  30          
Ala Pro Ser Arg Glu Arg Arg Ser Asp Arg Gly Gln Ala Asp Arg Ala 
        35                  40                  45              
Lys Pro Ala Ala Glu Pro Ala Thr Ala Gly Gly Gln Gly Thr Pro Gly 
    50                  55                  60                  
Gly Arg Arg Lys Pro Thr Ala Glu Gly Asn Gly Gly Cys Arg Arg Pro 
65                  70                  75                  80  
Gly Ala Gly Leu Ser Pro Lys Ala Gln Glu Arg Gln Ser Asn Ala Gln 
                85                  90                  95      
Arg Gln Gly Arg Gly Pro Arg Gly Gly Arg Gly Gly Arg Leu Glu Glu 
            100                 105                 110         
Gly Ser Leu Ser Gly Gly Glu Glu Leu Gly Gly Arg Arg Arg Arg Lys 
        115                 120                 125             
Arg Lys Asp Lys Gly Pro Ser Ala Arg Arg Gly Arg Arg Thr Pro Arg 
    130                 135                 140                 
Ser Leu Asn Gly Asp Thr Ser Gly Gly Asp Gly Gly Ser Ser Cys Pro 
145                 150                 155                 160 
Asp Ser Glu Thr Arg Glu Ala Gln Glu Ser Gly Ser Gln Arg Gly Thr 
                165                 170                 175     
Ala Arg Glu Leu Arg Pro Thr Pro Glu Pro Thr Asp Met Gly Ser Glu 
            180                 185                 190         
Gly Thr Lys Thr Gly Pro Glu Ser Ala Leu Glu Pro Ser Ser Asp Gly 
        195                 200                 205             
Leu Asp Ser Asp Trp Pro His Ala Asp Thr Arg Gly Arg Glu Gly Ser 
    210                 215                 220                 
Ser Gly Thr Gly Pro Leu Gly Ala Ser Glu His Ser Gly Gly Asp Ser 
225                 230                 235                 240 
Asp Ser Ser Pro Leu Gly Thr Gly Pro Gly Arg Gly Ser Arg Ala Ala 
                245                 250                 255     
Met Ala Ser Arg Thr Phe Glu Asp Ser Ser Arg Ala Pro Arg Asp Thr 
            260                 265                 270         
Gly Pro Ala Lys Asp Ala Ser Asp Asn Arg Ala Gln Arg Gly Ala Glu 
        275                 280                 285             
Pro Glu Thr Met Gln Ala Ser Thr Ala Arg Ala Pro Arg His Gln Val 
    290                 295                 300                 
Gly Lys Ala Val Gly Gln Val Pro Ala Ala Ala Gly Glu Gly Glu Ala 
305                 310                 315                 320 
Gly Ala Ala Ala Gly Ala Gly Pro Glu Asp Pro Ala Pro Leu Ala Ala 
                325                 330                 335     
Leu Leu Val Val Arg Arg Leu Leu Ala Arg Pro Pro Pro Gly Ala Ala 
            340                 345                 350         
Ser Gln Ala Val Gly Pro Arg Arg Ala Gly Leu Lys Glu Arg Leu Leu 
        355                 360                 365             
Ser Val Ala Arg Ala Leu Gly Leu Leu Arg Trp Leu Arg Arg Arg Leu 
    370                 375                 380                 
Arg Leu Arg Arg Arg Pro Pro Glu Gly Glu Gly Gln Gly Thr Gly Pro 
385                 390                 395                 400 
Arg Ala Ser Glu Gly Trp Gly Arg Arg Lys Pro Asp Glu Gly Arg Gly 
                405                 410                 415     
His Gly Arg Gly Ser Lys Gly Arg Gly Arg Gly Lys Ala Asp Glu Gly 
            420                 425                 430         
Arg Gly His Glu Arg Gly Asp Glu Gly Arg Gly Arg Gly Lys Ala Asp 
        435                 440                 445             
Glu Gly Arg Gly His Glu Arg Gly Tyr Glu Gly Arg Gly Cys Gly Lys 
    450                 455                 460                 
Ala Asp Glu Gly Arg Gly His Glu Arg Gly Asp Glu Gly Arg Asp His 
465                 470                 475                 480 
Gln Arg Gly Tyr Glu Gly Trp Gly Arg Glu Pro Gly Leu Arg His Arg 
                485                 490                 495     
Leu Ala Leu Arg Leu Ala Gly Leu Ala Gly Leu Gly Gly Met Pro Arg 
            500                 505                 510         
Ala Ser Pro Gly Gly Arg Ser Pro Gln Val Pro Thr Ser Pro Val Pro 
        515                 520                 525             
Gly Asp Pro Phe Asp Gln Glu Asp Glu Thr Pro Asp Pro Lys Phe Ala 
    530                 535                 540                 
Val Val Phe Pro Arg Ile His Arg Ala Gly Arg Ala Ser Ser Ser Arg 
545                 550                 555                 560 
Ser Ser Glu Glu Ala Ser Ala Asp Ala Pro Thr Gly Glu Gly Arg Gly 
                565                 570                 575     
Trp Pro Arg Ala Gly Val Gly Gly His Ser Glu Gly Cys Arg Thr Ser 
            580                 585                 590         
Gly Glu Gly Val Ser Gly Leu Arg Arg Gly Ser Leu Leu Ala Pro Thr 
        595                 600                 605             
Ala Pro Asp Gly Pro Ser Leu Asp Glu Ser Gly Ser Ser Ser Glu Ala 
    610                 615                 620                 
Glu Leu Glu Thr Leu Asn Asp Glu Pro Pro Val Arg Trp Ala Gln Gly 
625                 630                 635                 640 
Ser Gly Pro His Glu Gly Pro Arg Leu Gly Ala Ala Val Leu Leu Pro 
                645                 650                 655     
Arg Leu Ser Leu Glu Thr Arg Leu Gln Gln Glu Gly Asp Pro Gly Leu 
            660                 665                 670         
Arg Gly Ser Leu Arg Glu Leu Trp Glu Pro Glu Asp Glu Asp Glu Ala 
        675                 680                 685             
Val Leu Glu Arg Asp Leu Glu Leu Ser Leu Arg Pro Gly Leu Glu Ala 
    690                 695                 700                 
Pro Pro Phe Pro Gly Ala Lys Gly Arg Ser Leu Gly Asp Gly Leu Glu 
705                 710                 715                 720 
Asp Met Glu Asp Leu Ala Arg Leu Arg Leu Val Cys Asp Ser Ser Val 
                725                 730                 735     
Leu Leu Cys Leu Lys Lys Arg Phe His Leu Gly Arg Ile Tyr Thr Phe 
            740                 745                 750         
Gly Gly Pro Val Leu Leu Val Leu Asn Pro His Arg Ser Leu Pro Leu 
        755                 760                 765             
Phe Ser Pro Glu Val Gln Ala Ser Tyr His Pro Arg Lys Ala Leu Ser 
    770                 775                 780                 
Thr Thr Pro His Ile Phe Ala Ile Val Ala Ser Ala Tyr Asp Leu Ala 
785                 790                 795                 800 
Gln Asn Thr Gly Gln Asp Pro Cys Ile Leu Leu Cys Ser Ser His Cys 
                805                 810                 815     
Ser Gly His Ser Gly Ser Gly Lys Thr Glu Ala Ala Lys Lys Ile Met 
            820                 825                 830         
Gln Phe Leu Ser Ser Leu Glu Gln Asp Gln Thr Gly Asn Arg Glu Cys 
        835                 840                 845             
Gln Val Glu Asp Met Leu Pro Ile Leu Ser Ser Phe Gly His Ala Lys 
    850                 855                 860                 
Thr Ile Leu Asn Ala Asn Ala Ser Arg Phe Gly Gln Val Phe Cys Leu 
865                 870                 875                 880 
Tyr Leu Gln Gln Gly Val Ile Val Gly Ala Ser Val Ser His Tyr Leu 
                885                 890                 895     
Leu Glu Thr Ser Arg Val Val Phe Gln Gly Gln Ala Cys Arg Leu Gln 
            900                 905                 910         
Gly Lys Glu Asp Ala Gln Asp Phe Glu Gly Leu Leu Lys Ala Leu Gln 
        915                 920                 925             
Gly Leu Gly Leu Cys Pro Glu Glu Leu Asn Ala Val Trp Ala Val Leu 
    930                 935                 940                 
Ala Ala Ile Leu Gln Leu Gly Asn Ile Cys Phe Ser Ser Ser Glu Arg 
945                 950                 955                 960 
Glu Ser Gln Glu Val Ala Ala Val Ser Ser Trp Ala Glu Ile His Thr 
                965                 970                 975     
Ala Ala Arg Leu Leu Arg Val Pro Pro Glu Cys Leu Glu Gly Ala Val 
            980                 985                 990         
Thr Arg Arg Val Thr Glu Thr Pro Tyr Gly Gln Val Ser Arg Ser Leu 
        995                 1000                1005            
Pro Val Glu Ser Ala Phe Asp Ala Arg Asp Ala Leu Ala Lys Ala Leu 
    1010                1015                1020                
Tyr Ser Arg Leu Phe His Arg Leu Leu Arg Arg Thr Asn Ala Arg Leu 
1025                1030                1035                1040
Ala Pro Pro Gly Glu Gly Gly Ser Ile Gly Thr Val Thr Val Val Asp 
                1045                1050                1055    
Ala Tyr Gly Phe Glu Ala Leu Arg Val Asn Gly Leu Glu Gln Leu Cys 
            1060                1065                1070        
Asn Asn Leu Ala Ser Glu Arg Leu Gln Leu Phe Ser Ser Gln Met Leu 
        1075                1080                1085            
Leu Ala Gln Glu Glu Glu Glu Cys Arg Arg Glu Leu Leu Ser Trp Val 
    1090                1095                1100                
Pro Val Pro Gln Pro Pro Arg Glu Ser Cys Leu Asp Leu Leu Val Asp 
1105                1110                1115                1120
Gln Pro His Ser Leu Leu Ser Ile Leu Asp Ala Gln Thr Trp Leu Ser 
                1125                1130                1135    
Gln Ala Thr Asp His Thr Phe Leu Gln Lys Ser His Tyr His His Gly 
            1140                1145                1150        
Asp His Pro Ser Tyr Ala Lys Pro Arg Leu Pro Leu Pro Val Phe Thr 
        1155                1160                1165            
Val Arg His Tyr Ala Gly Thr Val Thr Tyr Gln Val His Lys Phe Leu 
    1170                1175                1180                
Asn Arg Asn Arg Asp Gln Leu Asp Pro Ala Val Val Glu Met Leu Gly 
1185                1190                1195                1200
Gln Ser Gln Leu Gln Leu Val Gly Ser Leu Phe Gln Glu Ala Glu Pro 
                1205                1210                1215    
Gln Ser Arg Gly Gly Arg Gly Arg Pro Thr Leu Ala Ser Arg Phe Gln 
            1220                1225                1230        
Gln Ala Leu Glu Asp Leu Ile Ala Arg Leu Gly Arg Ser His Val Tyr 
        1235                1240                1245            
Phe Ile Gln Cys Leu Thr Pro Asn Pro Gly Lys Leu Pro Gly Leu Phe 
    1250                1255                1260                
Asp Val Gly His Val Thr Glu Gln Leu His Gln Ala Ala Ile Leu Glu 
1265                1270                1275                1280
Ala Val Gly Thr Arg Ser Ala Asn Phe Pro Val Arg Val Pro Phe Glu 
                1285                1290                1295    
Ala Phe Leu Ala Ser Phe Gln Ala Leu Gly Ser Glu Gly Gln Glu Asp 
            1300                1305                1310        
Leu Ser Asp Arg Glu Lys Cys Gly Ala Val Leu Ser Gln Val Leu Gly 
        1315                1320                1325            
Ala Glu Ser Pro Leu Tyr His Leu Gly Ala Thr Lys Val Leu Leu Gln 
    1330                1335                1340                
Glu Gln Gly Trp Gln Arg Leu Glu Glu Leu Arg Asp Gln Gln Arg Ser 
1345                1350                1355                1360
Gln Ala Leu Val Asp Leu His Arg Ser Phe His Thr Cys Ile Ser Arg 
                1365                1370                1375    
Gln Arg Val Leu Pro Arg Met Gln Ala Arg Met Arg Gly Phe Gln Ala 
            1380                1385                1390        
Arg Lys Arg Tyr Leu Arg Arg Arg Ala Ala Leu Gly Gln Leu Asn Thr 
        1395                1400                1405            
Ile Leu Leu Val Ala Gln Pro Leu Leu Gln Arg Arg Gln Arg Leu Gln 
    1410                1415                1420                
Leu Gly Arg Trp Gln Gly Trp His Ser Ser Glu Arg Ala Leu Glu Arg 
1425                1430                1435                1440
Val Pro Ser Met Glu Leu Gly Arg Leu Glu Ile Pro Ala Glu Leu Ala 
                1445                1450                1455    
Val Met Leu Lys Thr Ala Glu Ser His Arg Asp Ala Leu Ala Gly Ser 
            1460                1465                1470        
Ile Thr Glu Cys Leu Pro Pro Glu Val Pro Ala Arg Pro Ser Leu Thr 
        1475                1480                1485            
Leu Pro Ala Asp Ile Asp Leu Phe Pro Phe Ser Ser Phe Val Ala Ile 
    1490                1495                1500                
Gly Phe Gln Glu Pro Ser Leu Pro Arg Pro Gly Gln Pro Leu Ala Lys 
1505                1510                1515                1520
Pro Leu Thr Gln Leu Asp Gly Asp Asn Pro Gln Arg Ala Leu Asp Ile 
                1525                1530                1535    
Asn Lys Val Met Leu Arg Leu Leu Gly Asp Gly Ser Leu Glu Ser Trp 
            1540                1545                1550        
Gln Arg Gln Ile Met Gly Ala Tyr Leu Val Arg Gln Gly Gln Cys Arg 
        1555                1560                1565            
Pro Gly Leu Arg Asn Glu Leu Phe Ser Gln Leu Val Ala Gln Leu Trp 
    1570                1575                1580                
Gln Asn Pro Asp Glu Gln Gln Ser Gln Arg Gly Trp Ala Leu Met Ala 
1585                1590                1595                1600
Val Leu Leu Ser Ala Phe Pro Pro Leu Pro Val Leu Gln Lys Pro Leu 
                1605                1610                1615    
Leu Lys Phe Val Ser Asp Gln Ala Pro Arg Gly Met Ala Ala Leu Cys 
            1620                1625                1630        
Gln His Lys Leu Leu Gly Ala Leu Glu Gln Ser Gln Leu Ala Ser Gly 
        1635                1640                1645            
Ala Thr Arg Ala His Pro Pro Thr Gln Leu Glu Trp Leu Ala Gly Trp 
    1650                1655                1660                
Arg Arg Gly Arg Met Ala Leu Asp Val Phe Thr Phe Ser Glu Glu Cys 
1665                1670                1675                1680
Tyr Ser Ala Glu Val Glu Ser Trp Thr Thr Gly Glu Gln Leu Ala Gly 
                1685                1690                1695    
Trp Ile Leu Gln Ser Arg Gly Leu Glu Ala Pro Pro Arg Gly Trp Ser 
            1700                1705                1710        
Val Ser Leu His Ser Arg Asp Ala Trp Gln Asp Leu Ala Gly Cys Asp 
        1715                1720                1725            
Phe Val Leu Asp Leu Ile Ser Gln Thr Glu Asp Leu Gly Asp Pro Ala 
    1730                1735                1740                
Arg Pro Arg Ser Tyr Pro Ile Thr Pro Leu Gly Ser Ala Glu Ala Ile 
1745                1750                1755                1760
Pro Leu Ala Pro Gly Ile Gln Ala Pro Ser Leu Pro Pro Gly Pro Pro 
                1765                1770                1775    
Pro Gly Pro Ala Pro Thr Leu Pro Ser Arg Asp His Thr Gly Glu Val 
            1780                1785                1790        
Gln Arg Ser Gly Ser Leu Asp Gly Phe Leu Asp Gln Ile Phe Gln Pro 
        1795                1800                1805            
Val Ile Ser Ser Gly Leu Ser Asp Leu Glu Gln Ser Trp Ala Leu Ser 
    1810                1815                1820                
Ser Arg Met Lys Gly Gly Gly Ala Ile Gly Pro Thr Gln Gln Gly Tyr 
1825                1830                1835                1840
Pro Met Val Tyr Pro Gly Met Ile Gln Met Pro Ala Tyr Gln Pro Gly 
                1845                1850                1855    
Met Val Pro Ala Pro Met Pro Met Met Pro Ala Met Gly Thr Val Pro 
            1860                1865                1870        
Ala Met Pro Ala Met Val Val Pro Pro Gln Pro Pro Leu Pro Ser Leu 
        1875                1880                1885            
Asp Ala Gly Gln Leu Ala Val Gln Gln Gln Asn Phe Ile Gln Gln Gln 
    1890                1895                1900                
Ala Leu Ile Leu Ala Gln Gln Met Thr Ala Gln Ala Met Ser Leu Ser 
1905                1910                1915                1920
Leu Glu Gln Gln Met Gln Gln Arg Gln Gln Gln Ala Arg Ala Ser Glu 
                1925                1930                1935    
Ala Ala Ser Gln Ala Ser Pro Ser Ala Val Thr Ser Lys Pro Arg Lys 
            1940                1945                1950        
Pro Pro Thr Pro Pro Glu Lys Pro Gln Arg Asp Leu Gly Ser Glu Gly 
        1955                1960                1965            
Gly Cys Leu Arg Glu Thr Ser Glu Glu Ala Glu Asp Arg Pro Tyr Gln 
    1970                1975                1980                
Pro Lys Ser Phe Gln Gln Lys Arg Asn Tyr Phe Gln Arg Met Gly Gln 
1985                1990                1995                2000
Pro Gln Ile Thr Val Arg Thr Met Lys Pro Pro Ala Lys Val His Ile 
                2005                2010                2015    
Pro Gln Gly Glu Ala Gln Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            2020                2025                2030        
Glu Gln Glu Glu Gln Glu Val Glu Thr Arg Ala Val Pro Ser Pro Pro 
        2035                2040                2045            
Pro Pro Pro Ile Val Lys Lys Pro Leu Lys Gln Gly Gly Ala Lys Ala 
    2050                2055                2060                
Pro Lys Glu Ala Glu Ala Glu Pro Ala Lys Glu Thr Ala Ala Lys Gly 
2065                2070                2075                2080
His Gly Gln Gly Pro Ala Gln Gly Arg Gly Thr Val Val Arg Ser Ser 
                2085                2090                2095    
Asp Ser Lys Pro Lys Arg Pro Gln Pro Ser Arg Glu Ile Gly Asn Ile 
            2100                2105                2110        
Ile Arg Met Tyr Gln Ser Arg Pro Gly Pro Val Pro Val Pro Val Gln 
        2115                2120                2125            
Pro Ser Arg Pro Pro Lys Ala Phe Leu Arg Lys Ile Asp Pro Lys Asp 
    2130                2135                2140                
Glu Ala Leu Ala Lys Leu Gly Ile Asn Gly Ala His Ser Ser Pro Pro 
2145                2150                2155                2160
Met Leu Ser Pro Ser Pro Gly Lys Gly Pro Pro Pro Ala Val Ala Pro 
                2165                2170                2175    
Arg Pro Lys Ala Pro Leu Gln Leu Gly Pro Ser Ser Ser Ile Lys Glu 
            2180                2185                2190        
Lys Gln Gly Pro Leu Leu Asp Leu Phe Gly Gln Lys Leu Pro Ile Ala 
        2195                2200                2205            
His Thr Pro Pro Pro Pro Pro Ala Pro Pro Leu Pro Leu Pro Glu Asp 
    2210                2215                2220                
Pro Gly Thr Leu Ser Ala Glu Arg Arg Cys Leu Thr Gln Pro Val Glu 
2225                2230                2235                2240
Asp Gln Gly Val Ser Thr Gln Leu Leu Ala Pro Ser Gly Ser Val Cys 
                2245                2250                2255    
Phe Ser Tyr Thr Gly Thr Pro Trp Lys Leu Phe Leu Arg Lys Glu Val 
            2260                2265                2270        
Phe Tyr Pro Arg Glu Asn Phe Ser His Pro Tyr Tyr Leu Arg Leu Leu 
        2275                2280                2285            
Cys Glu Gln Ile Leu Arg Asp Thr Phe Ser Glu Ser Cys Ile Arg Ile 
    2290                2295                2300                
Ser Gln Asn Glu Arg Arg Lys Met Lys Asp Leu Leu Gly Gly Leu Glu 
2305                2310                2315                2320
Val Asp Leu Asp Ser Leu Thr Thr Thr Glu Asp Ser Val Lys Lys Arg 
                2325                2330                2335    
Ile Val Val Ala Ala Arg Asp Asn Trp Ala Asn Tyr Phe Ser Arg Phe 
            2340                2345                2350        
Phe Pro Val Ser Gly Glu Ser Gly Ser Asp Val Gln Leu Leu Ala Val 
        2355                2360                2365            
Ser His Arg Gly Leu Arg Leu Leu Lys Val Thr Gln Gly Pro Gly Leu 
    2370                2375                2380                
Arg Pro Asp Gln Leu Lys Ile Leu Cys Ser Tyr Ser Phe Ala Glu Val 
2385                2390                2395                2400
Leu Gly Val Glu Cys Arg Gly Gly Ser Thr Leu Glu Leu Ser Leu Lys 
                2405                2410                2415    
Ser Glu Gln Leu Val Leu His Thr Ala Arg Ala Arg Ala Ile Glu Ala 
            2420                2425                2430        
Leu Val Glu Leu Phe Leu Asn Glu Leu Lys Lys Asp Ser Gly Tyr Val 
        2435                2440                2445            
Ile Ala Leu Arg Ser Tyr Ile Thr Asp Asn Cys Ser Leu Leu Ser Phe 
    2450                2455                2460                
His Arg Gly Asp Leu Ile Lys Leu Leu Pro Val Ala Thr Leu Glu Pro 
2465                2470                2475                2480
Gly Trp Gln Phe Gly Ser Ala Gly Gly Arg Ser Gly Leu Phe Pro Ala 
                2485                2490                2495    
Asp Ile Val Gln Pro Ala Ala Ala Pro Asp Phe Ser Phe Ser Lys Glu 
            2500                2505                2510        
Gln Arg Ser Gly Trp His Lys Gly Gln Leu Ser Asn Gly Glu Pro Gly 
        2515                2520                2525            
Leu Ala Arg Trp Asp Arg Ala Ser Glu Arg Pro Ala His Pro Trp Ser 
    2530                2535                2540                
Gln Ala His Ser Asp Asp Ser Glu Ala Thr Ser Leu Ser Ser Val Ala 
2545                2550                2555                2560
Tyr Ala Phe Leu Pro Asp Ser His Ser Tyr Thr Met Gln Glu Phe Ala 
                2565                2570                2575    
Arg Arg Tyr Phe Arg Arg Ser Gln Ala Leu Leu Gly Gln Thr Asp Gly 
            2580                2585                2590        
Gly Ala Ala Gly Lys Asp Thr Asp Ser Leu Val Gln Tyr Thr Lys Ala 
        2595                2600                2605            
Pro Ile Gln Glu Ser Leu Leu Ser Leu Ser Asp Asp Val Ser Lys Leu 
    2610                2615                2620                
Ala Val Ala Ser Phe Leu Ala Leu Met Arg Phe Met Gly Asp Gln Ser 
2625                2630                2635                2640
Lys Pro Arg Gly Lys Asp Glu Met Asp Leu Leu Tyr Glu Leu Leu Lys 
                2645                2650                2655    
Leu Cys Gln Gln Glu Lys Leu Arg Asp Glu Ile Tyr Cys Gln Val Ile 
            2660                2665                2670        
Lys Gln Val Thr Gly His Pro Arg Pro Glu His Cys Thr Arg Gly Trp 
        2675                2680                2685            
Ser Phe Leu Ser Leu Leu Thr Gly Phe Phe Pro Pro Ser Thr Arg Leu 
    2690                2695                2700                
Met Pro Tyr Leu Thr Lys Phe Leu Gln Asp Ser Gly Pro Ser Gln Glu 
2705                2710                2715                2720
Leu Ala Arg Ser Ser Gln Glu His Leu Gln Arg Thr Val Lys Tyr Gly 
                2725                2730                2735    
Gly Arg Arg Arg Met Pro Pro Pro Gly Glu Met Lys Ala Phe Leu Lys 
            2740                2745                2750        
Gly Gln Ala Ile Arg Leu Leu Leu Ile His Leu Pro Gly Gly Val Asp 
        2755                2760                2765            
Tyr Arg Thr Asn Ile Gln Thr Phe Thr Val Ala Ala Glu Val Gln Glu 
    2770                2775                2780                
Glu Leu Cys Arg Gln Met Gly Ile Thr Glu Pro Gln Glu Val Gln Glu 
2785                2790                2795                2800
Phe Ala Leu Phe Leu Ile Lys Glu Lys Ser Gln Leu Val Arg Pro Leu 
                2805                2810                2815    
Gln Pro Ala Glu Tyr Leu Asn Ser Val Val Val Asp Gln Asp Val Ser 
            2820                2825                2830        
Leu His Ser Arg Arg Leu His Trp Glu Thr Pro Leu His Phe Asp Asn 
        2835                2840                2845            
Ser Thr Tyr Ile Ser Thr His Tyr Ser Gln Val Leu Trp Asp Tyr Leu 
    2850                2855                2860                
Gln Gly Lys Leu Pro Val Ser Ala Lys Ala Asp Ala Gln Leu Ala Arg 
2865                2870                2875                2880
Leu Ala Ala Leu Gln His Leu Ser Lys Ala Asn Arg Asn Thr Pro Ser 
                2885                2890                2895    
Gly Gln Asp Leu Leu Ala Tyr Val Pro Lys Gln Leu Gln Arg Gln Val 
            2900                2905                2910        
Asn Thr Ala Ser Ile Lys Asn Leu Met Gly Gln Glu Leu Arg Arg Leu 
        2915                2920                2925            
Glu Gly His Ser Pro Gln Glu Ala Gln Ile Ser Phe Ile Glu Ala Met 
    2930                2935                2940                
Ser Gln Leu Pro Leu Phe Gly Tyr Thr Val Tyr Gly Val Leu Arg Val 
2945                2950                2955                2960
Ser Met Gln Ala Leu Ser Gly Pro Thr Leu Leu Gly Leu Asn Arg Gln 
                2965                2970                2975    
His Leu Ile Leu Met Asp Pro Ser Ser Gln Ser Leu Tyr Cys Arg Ile 
            2980                2985                2990        
Ala Leu Lys Ser Leu Gln Arg Leu His Leu Leu Ser Pro Leu Glu Glu 
        2995                3000                3005            
Lys Gly Pro Pro Gly Leu Glu Val Asn Tyr Gly Ser Ala Asp Asn Pro 
    3010                3015                3020                
Gln Thr Ile Trp Phe Glu Leu Pro Gln Ala Gln Glu Leu Leu Tyr Thr 
3025                3030                3035                3040
Thr Val Phe Leu Ile Asp Ser Ser Ala Ser Cys Thr Glu Trp Pro Ser 
                3045                3050                3055    
Ile Asn 
        

<210> 41
<211> 1095
<212> DNA
<213> Homo sapiens


<400> 41
atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag      60

gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc     120

gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg     180

atctttgtgg tcactgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag     240

ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgaccta     300

gcagagaccg tcatcgccag cactatcagc attgtgaacc aggtctctgg ctacttcgtg     360

ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt     420

ctctggtctc tggccatcat ttcctgggag agatggatgg tggtctgcaa gccctttggc     480

aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctgggct     540

gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccca cggcctgaag     600

acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg     660

attgtcctca tggtcacctg ctgcatcatc ccactcgcta tcatcatgct ctgctacctc     720

caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag     780

aaggcagaga aggaagtgac gcgcatggtg gtggtgatga tctttgcgta ctgcgtctgc     840

tggggaccct acaccttctt cgcatgcttt gctgctgcca accctggtta cgccttccac     900

cctttgatgg ctgccctgcc ggcctacttt gccaaaagtg ccactatcta caaccccgtt     960

atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag    1020

gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg    1080

gtatcgcctg catga                                                     1095


<210> 42
<211> 364
<212> PRT
<213> Homo sapiens


<400> 42
Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      
Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          
Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              
Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  
Thr Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  
Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      
Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Ile Val 
            100                 105                 110         
Asn Gln Val Ser Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             
Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 
Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 
Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     
Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         
Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             
Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 
Val Thr Cys Cys Ile Ile Pro Leu Ala Ile Ile Met Leu Cys Tyr Leu 
225                 230                 235                 240 
Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     
Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         
Met Ile Phe Ala Tyr Cys Val Cys Trp Gly Pro Tyr Thr Phe Phe Ala 
        275                 280                 285             
Cys Phe Ala Ala Ala Asn Pro Gly Tyr Ala Phe His Pro Leu Met Ala 
    290                 295                 300                 
Ala Leu Pro Ala Tyr Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 
Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     
Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         
Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 

<210> 43
<211> 1095
<212> DNA
<213> Homo sapiens


<400> 43
atggcccagc agtggagcct ccaaaggctc gcaggccgcc atccgcagga cagctatgag      60

gacagcaccc agtccagcat cttcacctac accaacagca actccaccag aggccccttc     120

gaaggcccga attaccacat cgctcccaga tgggtgtacc acctcaccag tgtctggatg     180

atctttgtgg tcattgcatc cgtcttcaca aatgggcttg tgctggcggc caccatgaag     240

ttcaagaagc tgcgccaccc gctgaactgg atcctggtga acctggcggt cgctgacctg     300

gcagagaccg tcatcgccag cactatcagc gttgtgaacc aggtctatgg ctacttcgtg     360

ctgggccacc ctatgtgtgt cctggagggc tacaccgtct ccctgtgtgg gatcacaggt     420

ctctggtctc tggccatcat ttcctgggag agatggatgg tggtctgcaa gccctttggc     480

aatgtgagat ttgatgccaa gctggccatc gtgggcattg ccttctcctg gatctgggct     540

gctgtgtgga cagccccgcc catctttggt tggagcaggt actggcccca cggcctgaag     600

acttcatgcg gcccagacgt gttcagcggc agctcgtacc ccggggtgca gtcttacatg     660

attgtcctca tggtcacctg ctgcatcacc ccactcagca tcatcgtgct ctgctacctc     720

caagtgtggc tggccatccg agcggtggca aagcagcaga aagagtctga atccacccag     780

aaggcagaga aggaagtgac gcgcatggtg gtggtgatgg tcctggcatt ctgcttctgc     840

tggggaccat acgccttctt cgcatgcttt gctgctgcca accctggcta ccccttccac     900

cctttgatgg ctgccctgcc ggccttcttt gccaaaagtg ccactatcta caaccccgtt     960

atctatgtct ttatgaaccg gcagtttcga aactgcatct tgcagctttt cgggaagaag    1020

gttgacgatg gctctgaact ctccagcgcc tccaaaacgg aggtctcatc tgtgtcctcg    1080

gtatcgcctg catga                                                     1095


<210> 44
<211> 364
<212> PRT
<213> Homo sapiens


<400> 44
Met Ala Gln Gln Trp Ser Leu Gln Arg Leu Ala Gly Arg His Pro Gln 
1               5                   10                  15      
Asp Ser Tyr Glu Asp Ser Thr Gln Ser Ser Ile Phe Thr Tyr Thr Asn 
            20                  25                  30          
Ser Asn Ser Thr Arg Gly Pro Phe Glu Gly Pro Asn Tyr His Ile Ala 
        35                  40                  45              
Pro Arg Trp Val Tyr His Leu Thr Ser Val Trp Met Ile Phe Val Val 
    50                  55                  60                  
Ile Ala Ser Val Phe Thr Asn Gly Leu Val Leu Ala Ala Thr Met Lys 
65                  70                  75                  80  
Phe Lys Lys Leu Arg His Pro Leu Asn Trp Ile Leu Val Asn Leu Ala 
                85                  90                  95      
Val Ala Asp Leu Ala Glu Thr Val Ile Ala Ser Thr Ile Ser Val Val 
            100                 105                 110         
Asn Gln Val Tyr Gly Tyr Phe Val Leu Gly His Pro Met Cys Val Leu 
        115                 120                 125             
Glu Gly Tyr Thr Val Ser Leu Cys Gly Ile Thr Gly Leu Trp Ser Leu 
    130                 135                 140                 
Ala Ile Ile Ser Trp Glu Arg Trp Met Val Val Cys Lys Pro Phe Gly 
145                 150                 155                 160 
Asn Val Arg Phe Asp Ala Lys Leu Ala Ile Val Gly Ile Ala Phe Ser 
                165                 170                 175     
Trp Ile Trp Ala Ala Val Trp Thr Ala Pro Pro Ile Phe Gly Trp Ser 
            180                 185                 190         
Arg Tyr Trp Pro His Gly Leu Lys Thr Ser Cys Gly Pro Asp Val Phe 
        195                 200                 205             
Ser Gly Ser Ser Tyr Pro Gly Val Gln Ser Tyr Met Ile Val Leu Met 
    210                 215                 220                 
Val Thr Cys Cys Ile Thr Pro Leu Ser Ile Ile Val Leu Cys Tyr Leu 
225                 230                 235                 240 
Gln Val Trp Leu Ala Ile Arg Ala Val Ala Lys Gln Gln Lys Glu Ser 
                245                 250                 255     
Glu Ser Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Val Val 
            260                 265                 270         
Met Val Leu Ala Phe Cys Phe Cys Trp Gly Pro Tyr Ala Phe Phe Ala 
        275                 280                 285             
Cys Phe Ala Ala Ala Asn Pro Gly Tyr Pro Phe His Pro Leu Met Ala 
    290                 295                 300                 
Ala Leu Pro Ala Phe Phe Ala Lys Ser Ala Thr Ile Tyr Asn Pro Val 
305                 310                 315                 320 
Ile Tyr Val Phe Met Asn Arg Gln Phe Arg Asn Cys Ile Leu Gln Leu 
                325                 330                 335     
Phe Gly Lys Lys Val Asp Asp Gly Ser Glu Leu Ser Ser Ala Ser Lys 
            340                 345                 350         
Thr Glu Val Ser Ser Val Ser Ser Val Ser Pro Ala 
        355                 360                 

<210> 45
<211> 1047
<212> DNA
<213> Homo sapiens


<400> 45
atgagaaaaa tgtcggagga agagttttat ctgttcaaaa atatctcttc agtggggccg      60

tgggatgggc ctcagtacca cattgcccct gtctgggcct tctacctcca ggcagctttc     120

atgggcactg tcttccttat agggttccca ctcaatgcca tggtgctggt ggccacactg     180

cgctacaaaa agttgcggca gcccctcaac tacattctgg tcaacgtgtc cttcggaggc     240

ttcctcctct gcatcttctc tgtcttccct gtcttcgtcg ccagctgtaa cggatacttc     300

gtcttcggtc gccatgtttg tgctttggag ggcttcctgg gcactgtagc aggtctggtt     360

acaggatggt cactggcctt cctggccttt gagcgctaca ttgtcatctg taagcccttc     420

ggcaacttcc gcttcagctc caagcatgca ctgacggtgg tcctggctac ctggaccatt     480

ggtattggcg tctccatccc acccttcttt ggctggagcc ggttcatccc tgagggcctg     540

cagtgttcct gtggccctga ctggtacacc gtgggcacca aataccgcag cgagtcctat     600

acgtggttcc tcttcatctt ctgcttcatt gtgcctctct ccctcatctg cttctcctac     660

actcagctgc tgagggccct gaaagctgtt gcagctcagc agcaggagtc agctacgacc     720

cagaaggctg aacgggaggt gagccgcatg gtggttgtga tggtaggatc cttctgtgtc     780

tgctacgtgc cctacgcggc cttcgccatg tacatggtca acaaccgtaa ccatgggctg     840

gacttacggc ttgtcaccat tccttcattc ttctccaaga gtgcttgcat ctacaatccc     900

atcatctact gcttcatgaa taagcagttc caagcttgca tcatgaagat ggtgtgtggg     960

aaggccatga cagatgaatc cgacacatgc agctcccaga aaacagaagt ttctactgtc    1020

tcgtctaccc aagttggccc caactga                                        1047


<210> 46
<211> 348
<212> PRT
<213> Homo sapiens


<400> 46
Met Arg Lys Met Ser Glu Glu Glu Phe Tyr Leu Phe Lys Asn Ile Ser 
1               5                   10                  15      
Ser Val Gly Pro Trp Asp Gly Pro Gln Tyr His Ile Ala Pro Val Trp 
            20                  25                  30          
Ala Phe Tyr Leu Gln Ala Ala Phe Met Gly Thr Val Phe Leu Ile Gly 
        35                  40                  45              
Phe Pro Leu Asn Ala Met Val Leu Val Ala Thr Leu Arg Tyr Lys Lys 
    50                  55                  60                  
Leu Arg Gln Pro Leu Asn Tyr Ile Leu Val Asn Val Ser Phe Gly Gly 
65                  70                  75                  80  
Phe Leu Leu Cys Ile Phe Ser Val Phe Pro Val Phe Val Ala Ser Cys 
                85                  90                  95      
Asn Gly Tyr Phe Val Phe Gly Arg His Val Cys Ala Leu Glu Gly Phe 
            100                 105                 110         
Leu Gly Thr Val Ala Gly Leu Val Thr Gly Trp Ser Leu Ala Phe Leu 
        115                 120                 125             
Ala Phe Glu Arg Tyr Ile Val Ile Cys Lys Pro Phe Gly Asn Phe Arg 
    130                 135                 140                 
Phe Ser Ser Lys His Ala Leu Thr Val Val Leu Ala Thr Trp Thr Ile 
145                 150                 155                 160 
Gly Ile Gly Val Ser Ile Pro Pro Phe Phe Gly Trp Ser Arg Phe Ile 
                165                 170                 175     
Pro Glu Gly Leu Gln Cys Ser Cys Gly Pro Asp Trp Tyr Thr Val Gly 
            180                 185                 190         
Thr Lys Tyr Arg Ser Glu Ser Tyr Thr Trp Phe Leu Phe Ile Phe Cys 
        195                 200                 205             
Phe Ile Val Pro Leu Ser Leu Ile Cys Phe Ser Tyr Thr Gln Leu Leu 
    210                 215                 220                 
Arg Ala Leu Lys Ala Val Ala Ala Gln Gln Gln Glu Ser Ala Thr Thr 
225                 230                 235                 240 
Gln Lys Ala Glu Arg Glu Val Ser Arg Met Val Val Val Met Val Gly 
                245                 250                 255     
Ser Phe Cys Val Cys Tyr Val Pro Tyr Ala Ala Phe Ala Met Tyr Met 
            260                 265                 270         
Val Asn Asn Arg Asn His Gly Leu Asp Leu Arg Leu Val Thr Ile Pro 
        275                 280                 285             
Ser Phe Phe Ser Lys Ser Ala Cys Ile Tyr Asn Pro Ile Ile Tyr Cys 
    290                 295                 300                 
Phe Met Asn Lys Gln Phe Gln Ala Cys Ile Met Lys Met Val Cys Gly 
305                 310                 315                 320 
Lys Ala Met Thr Asp Glu Ser Asp Thr Cys Ser Ser Gln Lys Thr Glu 
                325                 330                 335     
Val Ser Thr Val Ser Ser Thr Gln Val Gly Pro Asn 
            340                 345             

<210> 47
<211> 1047
<212> DNA
<213> Homo sapiens


<400> 47
atgaatggca cagaaggccc taacttctac gtgcccttct ccaatgcgac gggtgtggta      60

cgcagcccct tcgagtaccc acagtactac ctggctgagc catggcagtt ctccatgctg     120

gccgcctaca tgtttctgct gatcgtgctg ggcttcccca tcaacttcct cacgctctac     180

gtcaccgtcc agcacaagaa gctgcgcacg cctctcaact acatcctgct caacctagcc     240

gtggctgacc tcttcatggt cctaggtggc ttcaccagca ccctctacac ctctctgcat     300

ggatacttcg tcttcgggcc cacaggatgc aatttggagg gcttctttgc caccctgggc     360

ggtgaaattg ccctgtggtc cttggtggtc ctggccatcg agcggtacgt ggtggtgtgt     420

aagcccatga gcaacttccg cttcggggag aaccatgcca tcatgggcgt tgccttcacc     480

tgggtcatgg cgctggcctg cgccgcaccc ccactcgccg gctggtccag gtacatcccc     540

gagggcctgc agtgctcgtg tggaatcgac tactacacgc tcaagccgga ggtcaacaac     600

gagtcttttg tcatctacat gttcgtggtc cacttcacca tccccatgat tatcatcttt     660

ttctgctatg ggcagctcgt cttcaccgtc aaggaggccg ctgcccagca gcaggagtca     720

gccaccacac agaaggcaga gaaggaggtc acccgcatgg tcatcatcat ggtcatcgct     780

ttcctgatct gctgggtgcc ctacgccagc gtggcattct acatcttcac ccaccagggc     840

tccaacttcg gtcccatctt catgaccatc ccagcgttct ttgccaagag cgccgccatc     900

tacaaccctg tcatctatat catgatgaac aagcagttcc ggaactgcat gctcaccacc     960

atctgctgcg gcaagaaccc actgggtgac gatgaggcct ctgctaccgt gtccaagacg    1020

gagacgagcc aggtggcccc ggcctaa                                        1047


<210> 48
<211> 348
<212> PRT
<213> Homo sapiens


<400> 48
Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      
Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          
Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              
Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  
His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  
Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      
Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         
Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             
Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 
Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 
Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     
Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         
Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             
Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 
Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 
Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     
Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         
Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             
Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 
Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 
Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     
Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             

<210> 49
<211> 15609
<212> DNA
<213> Homo sapiens


<400> 49
atgaattgcc cagttctttc attgggctct ggcttcttgt ttcaggtcat tgaaatgttg       60

atctttgcct attttgcttc aatatccttg actgagtcac gaggtctttt cccaaggctg      120

gagaacgtgg gagctttcaa gaaagtttcc atcgtgccaa cccaagcagt atgtggactc      180

ccagaccgaa gcactttttg tcacagctct gctgctgctg aaagtattca gttctgtacc      240

cagcggtttt gtattcagga ttgcccatac agatcttcac accctaccta cactgccctt      300

ttctcagcag gcctcagtag ctgcatcaca ccagacaaga atgatctgca tcctaacgcc      360

catagcaatt ctgcaagttt tatttttgga aatcacaaga gctgcttttc ttctcctcct      420

tctccaaagc tgatggcatc atttacctta gctgtatggc tgaaacctga gcaacaaggt      480

gtaatgtgtg ttatagaaaa gacagtagat gggcagattg tgttcaaact tacaatatct      540

gagaaagaga ccatgtttta ttatcgcaca gtaaatggtt tgcaacctcc aataaaagta      600

atgacactgg ggagaattct tgtgaagaaa tggattcatc ttagtgtgca ggtgcatcag      660

acaaaaatca gcttctttat caatggcgtg gagaaggatc atacaccttt caatgcaaga      720

actctaagtg gttcaattac agattttgca tctggtactg tgcaaatagg acagagttta      780

aatggtttag agcagtttgt cggaagaatg caagattttc gattatacca agtggcactt      840

acaaacagag agattctgga agtcttctct ggagatcttc tcagattgca tgcccaatca      900

cattgccgtt gccctggcag ccacccgcgg gtccaccctt tggcacagcg gtactgcatt      960

cctaatgatg caggagacac agctgataat agagtgtcac ggttgaatcc tgaagcccat     1020

cctctctctt ttgtcaatga taatgatgtt ggtacttcat gggtttcaaa tgtgtttaca     1080

aacattacac agcttaatca aggagtgact atttcagttg atttggaaaa tggacagtat     1140

caggtgtttt atattatcat tcagttcttt agtccacaac caacggaaat aaggattcaa     1200

aggaagaagg aaaatagttt agattgggag gactggcaat attttgccag gaattgtggt     1260

gcttttggaa tgaaaaacaa tggagatttg gaaaaacctg attctgtcaa ctgtcttcag     1320

ctttccaatt ttactccata ttcccgtggc aatgtcacat ttagcatcct gacacctgga     1380

ccaaattatc gtcctggata caataacttc tataataccc catctcttca agagttcgta     1440

aaagccacgc aaataaggtt tcattttcat gggcagtact atacaactga gactgctgtt     1500

aacctcagac acagatatta tgcagtggac gaaatcacca ttagtgggag atgtcagtgc     1560

catggtcatg ccgataactg cgacacaaca agccagccat atagatgcct ctgctcccag     1620

gagagcttca ctgaaggact tcattgtgat cgctgcttgc ctctttataa tgacaagcct     1680

ttccgccaag gtgatcaagt ttacgctttc aattgtaaac cttgtcaatg caacagccat     1740

tccaaaagct gccattacaa catctctgta gacccatttc cttttgagca cttcagaggg     1800

ggaggaggag tttgtgatga ttgtgagcat aacactacag gaaggaactg tgagctgtgc     1860

aaggattact ttttccgaca agttggtgca gatccttcgg ccatagatgt ttgcaaaccc     1920

tgtgactgtg atacagttgg cactagaaat ggtagcattc tttgtgatca gattggagga     1980

cagtgtaatt gtaagagaca cgtgtctggc aggcagtgca atcagtgcca gaatggattc     2040

tacaatctac aagagttgga tcctgatggc tgcagtccct gtaactgcaa tacctctggg     2100

acagtggatg gagatattac ctgtcaccaa aattcaggcc agtgcaagtg caaagcaaac     2160

gttattgggc ttaggtgtga tcattgcaat tttggattta aatttctccg aagctttaat     2220

gatgttggat gtgagccctg ccagtgtaac ctccatggct cagtgaacaa attctgcaat     2280

cctcactctg ggcagtgtga gtgcaaaaaa gaagccaaag gacttcagtg tgacacctgc     2340

agagaaaact tttatgggtt agatgtcacc aattgtaagg cctgtgactg tgacacagct     2400

ggatccctcc ctgggactgt ctgtaatgct aagacagggc agtgcatctg caagcccaat     2460

gttgaaggga gacagtgcaa taaatgtttg gagggaaact tctacctacg gcaaaataat     2520

tctttcctct gtctgccttg caactgtgat aagactggga caataaatgg ctctctgctg     2580

tgtaacaaat caacaggaca atgtccttgc aaattagggg taacaggtct tcgctgtaat     2640

cagtgtgagc ctcacaggta caatttgacc attgacaatt ttcaacactg ccagatgtgt     2700

gagtgtgatt ccttggggac attacctggg accatttgtg acccaatcag tggccagtgc     2760

ctgtgtgtgc ctaatcgtca aggaagaagg tgtaatcagt gtcaaccagg tttttatatt     2820

tctccaggca atgccactgg ctgcctgcca tgctcatgcc atacaactgg tgcagttaat     2880

cacatctgta atagcctgac tggtcagtgt gtttgccaag atgcttccat tgctgggcaa     2940

cgttgtgacc aatgcaaaga ccattacttt ggatttgatc ctcagactgg aagatgtcag     3000

ccttgtaatt gtcatctctc aggagccttg aatgaaacct gtcacttggt cacaggccag     3060

tgtttctgta aacaatttgt cactggctca aagtgtgatg cttgtgttcc cagtgcaagc     3120

cacttggatg tcaacaatct attgggttgc agcaaaactc cattccagca acctccgccc     3180

agaggacaag ttcaaagttc ttctgctatc aatctctcct ggagtccacc tgattctcca     3240

aatgcccact ggcttactta cagtttactc agggatggtt ttgaaatcta cacaacagag     3300

gatcaatacc catacagtat tcaatacttc ttagacacag acctgttacc atataccaaa     3360

tattcctatt acattgagac caccaatgtg catggttcaa caaggagtgt agctgtcact     3420

tacaagacaa aaccaggggt cccagaggga aacttgactt taagttatat cattcctatt     3480

ggctcagact ctgtgacact tacctggaca acactctcaa atcaatctgg tcccatagag     3540

aaatatattt tgtcctgtgc ccctttggct ggtggtcagc catgtgtttc ctacgaaggt     3600

catgaaacct cagctaccat ctggaatctg gttccatttg ccaagtacga tttttctgta     3660

caggcgtgta ctagcggggg ctgtttacac agcttgccca ttacagtgac cacagcccag     3720

gcccctcccc aaagactaag tccacctaag atgcagaaaa tcagttctac agaacttcat     3780

gtagaatggt ctccaccagc ggaactaaat ggaataatta taagatatga actatacatg     3840

agaagactga gatctactaa agaaaccaca tctgaggaaa gtcgagtttt tcagagcagt     3900

ggttggctca gtcctcattc atttgtagaa tcggccaatg aaaatgcatt aaaacctcct     3960

caaacaatga caaccatcac tggcttggag ccatacacca agtatgagtt cagagtctta     4020

gctgtgaata tggctggaag tgtgtcttct gcctgggtct cagaaagaac gggagaatca     4080

gcacctgtat tcatgatccc tccttcagtc tttcccctct cttcgtactc tctcaatatc     4140

tcctgggaga agccagcaga taatgttaca agaggaaaag ttgtggggta tgacatcaat     4200

atgctttctg aacaatcacc tcaacagtct attcccatgg cgttttcaca gctgttgcac     4260

actgctaaat cccaagaact atcttacact gtagaaggac tgaaacctta taggatatat     4320

gagtttacta ttactctctg caattcagtt ggttgtgtga ccagtgcttc gggagcagga     4380

caaactttag cagcagcacc agcacaactg aggccacctc tggttaaagg aatcaacagc     4440

acaacaatcc atcttaggtg gtttccacct gaagaactga atggaccctc tcctatatat     4500

cagctggaaa ggagagagtc atctctacca gctctgatga ccacgatgat gaaaggaatc     4560

cgtttcatag gaaatgggta ttgtaaattt cccagctcca ctcacccagt caatacagac     4620

ttcactggca ttaaggccag ctttcgaaca aaagtgcctg aaggtttgat tgtctttgca     4680

gcatcacctg gcaatcagga agagtatttt gcacttcagt tgaagaaggg acgtctttat     4740

tttctttttg atcctcaggg gtcaccagtg gaagtaacta caactaatga tcatggcaaa     4800

caatatagtg atggaaaatg gcatgaaata attgctatta ggcatcaggc ttttggccaa     4860

atcactctgg atgggatata tacaggttcc tctgccatcc tgaatggtag tactgttatt     4920

ggagataaca caggagtctt tctgggaggg ctcccgcgaa gttataccat cctcaggaag     4980

gatcctgaga taatccaaaa aggttttgtg ggctgtctca aggatgtaca ttttatgaag     5040

aattacaatc cgtcagctat ttgggaacct ctggattggc agagttctga agaacaaatc     5100

aacgtgtata acagctggga gggatgtccc gcttcattaa atgagggagc tcagttccta     5160

ggagcagggt tcctggaact tcatccatat atgtttcatg gtggaatgaa ctttgagatt     5220

tcctttaagt tcagaactga ccaattaaat ggattgcttc ttttcgttta taacaaagat     5280

ggacctgatt ttcttgctat ggagctgaaa agtggaatat tgaccttccg gttaaatacc     5340

agtcttgcct ttacacaagt ggatctattg ctggggctat cctattgtaa tggaaagtgg     5400

aataaagtca ttattaaaaa ggaaggctct ttcatatcag caagtgtgaa tggactgatg     5460

aagcatgcat cggagtccgg agaccagcca ctggtggtga attcaccagt ttatgtggga     5520

ggaatcccac aggaactgct gaactcttat caacatttgt gtttggaaca aggtttcggt     5580

ggttgcatga aggatgttaa atttacacgg ggtgctgtcg ttaacttggc atctgtgtcc     5640

agcggtgctg tcagagtcaa tctggatgga tgcctatcaa ctgacagtgc tgttaactgc     5700

aggggaaatg actccatcct ggtttaccag ggaaaagagc agagtgttta cgagggtggt     5760

ctccagcctt ttacagaata cctgtatcga gtgatagcct cgcatgaagg aggttcagta     5820

tatagtgatt ggagtcgagg acgtacaaca ggagcagctc cacaaagtgt gccaactccc     5880

tcaagagtcc gcagcttaaa tggatacagc attgaggtga cctgggatga acctgttgtc     5940

agaggtgtaa ttgagaagta cattctgaaa gcctatagtg aggacagcac ccgtccaccc     6000

cgcatgccct ctgccagtgc tgaatttgtc aatacaagca acctcacagg catattgaca     6060

ggcttgctac ccttcaaaaa ctatgcagta accctaactg cttgcacttt ggctggctgt     6120

actgagagct cacatgcatt gaacatctct actccacaag aagccccaca agaggttcag     6180

ccaccagtag ccaaatccct tcccagttct ttgctgctct cctggaaccc acccaaaaag     6240

gcaaatggta ttataactca gtactgttta tacatggatg ggaggctgat ctattcaggc     6300

agtgaggaga actacatagt cacagattta gcagtattta caccccacca gtttctacta     6360

agtgcatgca cacatgtggg ctgtacaaac agttcctggg tcctactgta cacagcacag     6420

ctgccaccag aacacgtgga ttccccagtt ctgactgtcc tggattctag aactatacac     6480

atacagtgga aacaaccaag aaaaataagt gggattctgg aacgctatgt attatatatg     6540

tcaaaccata cacatgattt tacaatttgg agtgtcatct ataacagtac agaacttttc     6600

caggatcata tgctacaata cgttttacct ggtaataaat atctcatcaa gctgggagct     6660

tgcacaggtg gtgggtgcac agtgagtgag gccagtgagg ccctaactga cgaggacata     6720

cccgaaggcg tgccagcccc caaagcccac tcatattcac ctgactcctt taatgtctcc     6780

tggactgagc ctgaatatcc gaatggtgtt atcacgagtt atggattata tctagatggt     6840

atattaatcc acaattcctc agaactcagc tatcgtgctt acggatttgc tccttggagt     6900

ttacattcct tcagagtcca agcatgcacg gccaaaggtt gtgctctggg cccactggtg     6960

gaaaatcgaa ctctagaagc tcctcctgaa ggaacagtaa atgtgtttgt caaaacacag     7020

ggatcccgga aagcccacgt gaggtgggaa gcaccttttc gccctaatgg actcttaaca     7080

cactcagtcc ttttcactgg gatattctat gtagacccag taggtaataa ctacaccctt     7140

ctgaatgtca caaaagtcat gtacagcgga gaagagacaa acctttgggt gctcatcgat     7200

gggctggttc cttttaccaa ctatactgta caagtgaata tttcaaatag ccaaggcagc     7260

ttgataactg atcctataac aattgcaatg cctccaggag ctccagatgg cgtgctgcct     7320

cccaggcttt catctgccac tccaaccagt cttcaggttg tctggtctac accagctcgt     7380

aataacgctc ctggctctcc cagataccaa ctccagatga ggtctggcga ctccacccat     7440

ggatttctag agttattttc caatccttct gcatcgttaa gctatgaagt gagtgatctc     7500

caaccgtaca cagagtatat gtttcggttg gttgcctcca atggatttgg cagtgcacat     7560

agttcttgga ttccattcat gaccgcagag gacaaacctg gacctgtagt tcctccgatt     7620

cttctggatg tgaagtcaag aatgatgttg gtcacctggc agcatcctag aaaatccaat     7680

ggggttatta cccattataa catttatcta catggccgtc tatacttgag aactcctgga     7740

aatgtcacta attgcacagt gatgcattta cacccataca ctgcctataa gtttcaggta     7800

gaagcctgca cttcaaaagg atgttccctt tcaccagagt cccagactgt atggacactc     7860

ccaggggcac cggaagggat cccaagtcca gagctgttct ctgatactcc aacatctgtg     7920

attatatctt ggcaaccccc tacccacccc aatggcttgg tggagaattt cacaattgag     7980

agaagagtca aaggaaagga agaagttact accctggtga ctctcccgag gagtcattcc     8040

atgaggttta ttgacaagac ttctgctctt agcccatgga caaaatatga atatcgggta     8100

ctgatgagca ctcttcatgg aggcacaaac agcagtgctt gggtagaagt taccacaaga     8160

ccctcacgac ctgctggggt gcagccacct gtggtgacag tgctggaacc cgatgcagtc     8220

caggtcactt ggaaaccccc actcatccag aacggagaca tacttagcta tgagattcac     8280

atgcctgacc ctcacatcac tttaaccaat gtgacttccg cagtgttaag tcaaaaagtt     8340

actcatctga ttcctttcac taattattct gtcaccattg ttgcttgctc agggggtaat     8400

gggtaccttg gagggtgcac agagagttta cctacctatg ttaccactca ccccaccgta     8460

cctcagaatg ttggcccatt gtctgtgatt ccactaagtg aatcatatgt tgtgatttct     8520

tggcaaccac catccaagcc aaatggacct aatttgagat atgagcttct gagacgtaaa     8580

atccagcagc cacttgcatc aaatccccca gaagatttaa atcggtggca caatatttat     8640

tcaggaactc agtggcttta tgaagataag ggtcttagca ggtttacaac ctatgaatat     8700

atgctcttcg tacacaacag tgtgggtttt acaccgagcc gagaagtgac tgtgacaacg     8760

ttagctggtc ttccagagag aggagccaat ctcactgcga gtgtccttaa ccacacagcc     8820

atcgacgtga ggtgggctaa accaactgtt caagacctac aaggtgaagt tgaatattac     8880

acactttttt ggagttctgc tacctcaaac gactctctaa aaatcttgcc agatgtaaac     8940

tctcatgtca ttggccacct aaagccaaac acagagtatt ggatctttat ctctgtcttc     9000

aatggagtcc acagcatcaa cagtgcagga cttcatgcaa ccacttgcga tggggagcct     9060

cagggcatgc ttcctccaga ggttgtcatc atcaacagta cagctgtacg tgtcatctgg     9120

acatctcctt caaacccaaa tggtgttgtc actgagtatt ctatctatgt aaataataag     9180

ctctacaaga ctggaatgaa tgtgcctggg tcgtttattc tgagagacct gtctcccttc     9240

actatctatg acattcaggt tgaagtctgc acaatatatg cctgcgtgaa aagcaatgga     9300

acccaaatta ccactgtgga agacactcca agtgatatac caacacccac aattcgtggc     9360

atcacttcaa gatctcttca aattgattgg gtgtctccac ggaagccaaa tggcatcatt     9420

cttggatatg atctcctatg gaaaacatgg tatccatgcg ctaaaactca aaagttagtg     9480

caggatcaga gtgatgagct ctgcaaggca gtgaggtgtc aaaaacctga atctatctgt     9540

ggacacattt gctattcttc tgaagctaag gtttgttgta acggagtgct ctataacccc     9600

aagcctggac atcgctgttg tgaagaaaag tatatcccgt ttgttctgaa ttctactgga     9660

gtttgttgtg gtggccgaat acaggaggca caaccaaatc atcagtgctg ctctgggtat     9720

tacgctagaa ttctaccagg tgaagtatgc tgtccagatg aacagcacaa tcgggtttct     9780

gttggcattg gtgattcctg ctgtggcaga atgccgtact ccacctcagg aaaccagatt     9840

tgctgtgctg ggaggcttca tgatggccat ggccagaagt gctgtggcag acagattgtg     9900

agcaacgatt tagagtgttg tggtggagaa gaaggagtgg tgtacaatcg ccttccaggt     9960

atgttctgtt gtgggcagga ttatgtgaat atgtcagata ccatatgctg ctcagcttcc    10020

agtggagagt ctaaagcaca tattaaaaag aatgacccgg tgccagtaaa atgctgtgag    10080

actgaactta ttccaaagag ccagaaatgc tgtaatggag ttggatataa tcctttgaaa    10140

tatgtttgct ctgacaagat ttcaactgga atgatgatga aggaaaccaa agagtgcagg    10200

atcctctgcc cagcatctat ggaagccaca gaacattgtg gcaggtgtga cttcaacttt    10260

accagccaca tttgcactgt gataagaggg tctcacaatt ccacagggaa ggcatcaatt    10320

gaagaaatgt gttcatctgc cgaagaaacc attcatacag ggagtgtaaa cacgtactct    10380

tacacagatg tgaacctcaa gccctacatg acatatgagt acaggatttc tgcctggaac    10440

agctatgggc gaggactcag caaagctgtg agagccagaa caaaagaaga tgtgcctcaa    10500

ggagtgagtc cccctacgtg gaccaaaata gacaatcttg aagatacaat tgtcttaaac    10560

tggagaaaac ctatacaatc aaatggtcct attatttact acatccttct tcgaaatgga    10620

attgaacgtt ttcggggaac atcactgagc ttctctgata aagagggaat tcaaccattt    10680

caggaatatt catatcagct gaaagcttgc acggttgctg gctgtgccac cagtagcaag    10740

gtagttgcag ctactaccca aggagttccg gagagcatcc tgccaccaag catcacagcc    10800

ctaagtgcag tggctctgca tctgagctgg agtgtccctg agaaatcaaa cggcgtcatt    10860

aaagagtacc agatcaggca ggttgggaaa ggtctcatcc acactgacac cactgacagg    10920

agacagcata cggtcacagg tctccagcca tacaccaact acagcttcac tcttacagct    10980

tgtacatctg ctgggtgcac ttcaagcgag ccttttctag gtcagacact gcaggcagct    11040

cctgaaggag tttgggtgac acctcgacac attatcatca attctacaac agtggaatta    11100

tattggagtc tgccagaaaa gcccaatggc ctcgtttctc aatatcaatt gagtcgtaat    11160

ggaaacttgc ttttcctggg tggcagtgag gagcagaatt tcactgataa aaacctggag    11220

cccaatagca gatacactta caagttagaa gtcaaaactg gaggtggcag cagtgctagt    11280

gatgattaca ttgttcaaac acctatgtca acaccagaag aaatctatcc tccatataat    11340

atcacagtaa ttgggcctta ttctatattt gtagcttgga taccaccagg gatcctcatc    11400

cccgaaattc ctgtggagta caatgtctta ctcaatgatg gaagtgtaac acctctggcc    11460

ttctccgttg gtcatcatca atccaccctt ctggaaaatt tgactccatt cacacagtat    11520

gagataagga tacaagcatg tcaaaatgga agttgtggag ttagcagtag gatgtttgtc    11580

aaaacacctg aagcagcccc aatggatctt aattctcctg ttcttaaggc actggggtca    11640

gcttgcatag agattaagtg gatgccacct gaaaaaccaa atggaatcat catcaactac    11700

tttatttaca gacgccctgc tggcattgaa gaggagtctg ttttatttgt ctggtcagaa    11760

ggagcccttg aatttatgga tgaaggagac accctgaggc ctttcacact ctacgaatat    11820

cgggtcagag cctgtaactc caagggttca gtggagagtc tgtggtcatt aacacaaact    11880

ctggaagctc cacctcaaga ttttccagct ccttgggctc aagccacgag tgctcattca    11940

gttctgttga attggacaaa gccagaatct cccaatggca ttatctccca ttaccgtgtg    12000

gtctaccagg agagacccga cgatcctaca tttaacagcc ctaccgtgca tgctttcaca    12060

gtgaagggaa caagccatca agcccacctg tacgggttag aaccattcac aacatatcgc    12120

attggtgttg tggctgcaaa ccatgcagga gaaattttaa gcccttggac tctgattcaa    12180

accttagaat cttccccaag tggactgaga aactttatag tagaacagaa agagaatggc    12240

cgggcattgc tactacagtg gtcagaacct atgagaacca atggtgtgat taagacatac    12300

aacatcttca gtgacgggtt cctggagtac tctggtttga atcgtcagtt tctcttccgc    12360

cgcctggatc ctttcactct ctacacactg accctggagg cctgcaccag agcaggttgt    12420

gcacactcgg cgcctcagcc tctgtggaca gatgaagccc ctccagactc tcagctggct    12480

cctactgtcc actctgtgaa gtccaccagt gttgagctga gctggtctga gcctgttaac    12540

ccaaatggaa aaataattcg ctatgaagtg attcgcagat gcttcgaggg aaaagcttgg    12600

ggaaatcaga caatccaggc cgacgagaaa attgttttca cagaatataa cactgaaagg    12660

aatacattta tgtataatga cacaggtttg caaccatgga cgcagtgtga atataaaatc    12720

tacacttgga attcagctgg gcatacctgt agctcttgga atgtggtgag gacattgcaa    12780

gcacctccag aaggtctctc tccacctgtg atatcctatg tttctatgaa tccccaaaaa    12840

ctgctgattt cctggatccc accagaacag tctaatggta ttatccagtc ctataggctt    12900

caaaggaatg aaatgctcta tccttttagc tttgatcctg tgactttcaa ttacactgat    12960

gaagagcttc ttcctttttc cacctatagc tatgcactcc aagcctgcac gagtggagga    13020

tgctccacca gcaaacccac cagcatcaca actctggagg ctgctccatc agaagtcagc    13080

cctccagatc tttgggccgt cagtgccact caaatgaatg tatgttggtc accgcccaca    13140

gtgcaaaatg gaaagattac taaatattta gttagatatg ataataaaga gtcccttgct    13200

ggccagggcc tgtgcctgct ggtttcccac ctgcagcctt actctcagta taacttctcc    13260

cttgtagcct gcacgaatgg aggttgcaca gctagtgtgt caaaatctgc ctggacaatg    13320

gaggccctgc cagagaacat ggactctcca acattgcaag tcacaggctc agaatcaata    13380

gaaatcacct ggaaacctcc aagaaaccca aatggccaga tcagaagtta tgaacttagg    13440

agggatggaa ccattgtata tacaggcttg gaaacacgct atcgtgattt tactctcacc    13500

ccaggtgtgg agtatagcta cacagtaact gccagcaaca gccaaggggg tattttgagt    13560

cctcttgtca aagatcgaac cagcccctca gcaccctcag ggatggaacc tccaaaattg    13620

caggccaggg gtcctcagga gatcttagtg aactgggacc ctccagtgag aacaaatggt    13680

gatatcatca attataccct cttcatccgt gaactatttg aaagagaaac taaaatcata    13740

cacataaaca caactcataa ttcttttggt atgcagtcat atatagtaaa ccagctgaag    13800

ccatttcaca ggtatgaaat acgaattcaa gcgtgcacca ccctgggatg tgcatcaagt    13860

gactggacat tcatacagac ccctgagatt gcacctttga tgcaaccccc tccacatctg    13920

gaggtacaaa tggctccagg aggattccag ccaactgttt ctcttttgtg gacaggaccg    13980

ctgcagccaa atggaaaagt tttgtattac gaattataca gaagacaaat agcaactcag    14040

cctagaaaat ccaatccagt cctaatctat aacggaagct caacatcttt tatagattcc    14100

gaactattgc ctttcacaga gtatgagtat caggtctggg cagtgaattc tgcaggaaaa    14160

gcccccagta gctggacatg gtgcagaacc gggccagccc caccagaagg tctcagagcc    14220

cccacgttcc atgtgatctc ttctacccaa gcagtggtca acatcagtgc ccctgggaag    14280

cccaacggga tcgtcagtct ctacaggctg ttctccagca gcgcccatgg ggctgagaca    14340

gtgctatccg aaggcatggc cacccagcag actctccatg gccttcaagc cttcactaac    14400

tactctattg gagtagaggc ctgcacctgc ttcaactgtt gcagcaaagg accgacagct    14460

gaactgagaa cccatcctgc cccaccctca ggactgtcct ctccacaaat cgggacgctg    14520

gcctcaagga cggcctcctt ccggtggagt ccccccatgt tccccaatgg tgtcattcac    14580

agctatgaac tccaattcca cgtggcttgc cctcctgact cagccctccc ctgtactccc    14640

agccaaatag aaacaaagta cacggggctg gggcagaaag ccagccttgg gggtctccag    14700

ccctacacca catacaagct gagagtggtg gcacacaacg aggtgggcag tacggcttcc    14760

gagtggatca gtttcaccac ccaaaaagaa ttgcctcagt accgagcccc attttcggtg    14820

gacagcaatt tgtctgtggt gtgtgtgaac tggagtgaca ccttcctcct gaacggccaa    14880

ctgaaggagt acgtgttaac cgacggaggg cgacgcgtgt acagcggctt ggacaccacc    14940

ctctacatac cgagaacggc ggacaaaacc ttctttttcc aggtcatctg cacgactgac    15000

gaaggaagtg ttaagacgcc gttgatccaa tatgatacct ctactggact tggcttggtc    15060

ctaacaactc ctgggaaaaa gaagggatcg cggagcaaaa gcacagagtt ctacagcgag    15120

ctgtggttca tagtgttaat ggcgatgctg ggcttgatct tgttggccat ttttctgtcc    15180

ctgatactac aaagaaaaat ccacaaagag ccatatatca gagaaagacc tcccttggta    15240

cctcttcaga agaggatgtc tccattgaat gtttacccac cgggggaaaa ccatatgggg    15300

ttagccgata ccaaaattcc ccggtctggg acacctgtga gtatccgcag caaccggagt    15360

gcatgtgtcc tgcgcatccc gagtcaaaac caaaccagcc taacctactc ccagggttct    15420

cttcaccgca gcgtcagcca gctcatggac attcaagaca agaaagtctt gatggacaac    15480

tcactgtggg aagccatcat gggccacaac agtggactgt atgtggatga agaggacctg    15540

atgaacgcca tcaaggattt cagctcagtg actaaggaac gcaccacatt cacagacacc    15600

cacctgtaa                                                            15609


<210> 50
<211> 5202
<212> PRT
<213> Homo sapiens


<400> 50
Met Asn Cys Pro Val Leu Ser Leu Gly Ser Gly Phe Leu Phe Gln Val 
1               5                   10                  15      
Ile Glu Met Leu Ile Phe Ala Tyr Phe Ala Ser Ile Ser Leu Thr Glu 
            20                  25                  30          
Ser Arg Gly Leu Phe Pro Arg Leu Glu Asn Val Gly Ala Phe Lys Lys 
        35                  40                  45              
Val Ser Ile Val Pro Thr Gln Ala Val Cys Gly Leu Pro Asp Arg Ser 
    50                  55                  60                  
Thr Phe Cys His Ser Ser Ala Ala Ala Glu Ser Ile Gln Phe Cys Thr 
65                  70                  75                  80  
Gln Arg Phe Cys Ile Gln Asp Cys Pro Tyr Arg Ser Ser His Pro Thr 
                85                  90                  95      
Tyr Thr Ala Leu Phe Ser Ala Gly Leu Ser Ser Cys Ile Thr Pro Asp 
            100                 105                 110         
Lys Asn Asp Leu His Pro Asn Ala His Ser Asn Ser Ala Ser Phe Ile 
        115                 120                 125             
Phe Gly Asn His Lys Ser Cys Phe Ser Ser Pro Pro Ser Pro Lys Leu 
    130                 135                 140                 
Met Ala Ser Phe Thr Leu Ala Val Trp Leu Lys Pro Glu Gln Gln Gly 
145                 150                 155                 160 
Val Met Cys Val Ile Glu Lys Thr Val Asp Gly Gln Ile Val Phe Lys 
                165                 170                 175     
Leu Thr Ile Ser Glu Lys Glu Thr Met Phe Tyr Tyr Arg Thr Val Asn 
            180                 185                 190         
Gly Leu Gln Pro Pro Ile Lys Val Met Thr Leu Gly Arg Ile Leu Val 
        195                 200                 205             
Lys Lys Trp Ile His Leu Ser Val Gln Val His Gln Thr Lys Ile Ser 
    210                 215                 220                 
Phe Phe Ile Asn Gly Val Glu Lys Asp His Thr Pro Phe Asn Ala Arg 
225                 230                 235                 240 
Thr Leu Ser Gly Ser Ile Thr Asp Phe Ala Ser Gly Thr Val Gln Ile 
                245                 250                 255     
Gly Gln Ser Leu Asn Gly Leu Glu Gln Phe Val Gly Arg Met Gln Asp 
            260                 265                 270         
Phe Arg Leu Tyr Gln Val Ala Leu Thr Asn Arg Glu Ile Leu Glu Val 
        275                 280                 285             
Phe Ser Gly Asp Leu Leu Arg Leu His Ala Gln Ser His Cys Arg Cys 
    290                 295                 300                 
Pro Gly Ser His Pro Arg Val His Pro Leu Ala Gln Arg Tyr Cys Ile 
305                 310                 315                 320 
Pro Asn Asp Ala Gly Asp Thr Ala Asp Asn Arg Val Ser Arg Leu Asn 
                325                 330                 335     
Pro Glu Ala His Pro Leu Ser Phe Val Asn Asp Asn Asp Val Gly Thr 
            340                 345                 350         
Ser Trp Val Ser Asn Val Phe Thr Asn Ile Thr Gln Leu Asn Gln Gly 
        355                 360                 365             
Val Thr Ile Ser Val Asp Leu Glu Asn Gly Gln Tyr Gln Val Phe Tyr 
    370                 375                 380                 
Ile Ile Ile Gln Phe Phe Ser Pro Gln Pro Thr Glu Ile Arg Ile Gln 
385                 390                 395                 400 
Arg Lys Lys Glu Asn Ser Leu Asp Trp Glu Asp Trp Gln Tyr Phe Ala 
                405                 410                 415     
Arg Asn Cys Gly Ala Phe Gly Met Lys Asn Asn Gly Asp Leu Glu Lys 
            420                 425                 430         
Pro Asp Ser Val Asn Cys Leu Gln Leu Ser Asn Phe Thr Pro Tyr Ser 
        435                 440                 445             
Arg Gly Asn Val Thr Phe Ser Ile Leu Thr Pro Gly Pro Asn Tyr Arg 
    450                 455                 460                 
Pro Gly Tyr Asn Asn Phe Tyr Asn Thr Pro Ser Leu Gln Glu Phe Val 
465                 470                 475                 480 
Lys Ala Thr Gln Ile Arg Phe His Phe His Gly Gln Tyr Tyr Thr Thr 
                485                 490                 495     
Glu Thr Ala Val Asn Leu Arg His Arg Tyr Tyr Ala Val Asp Glu Ile 
            500                 505                 510         
Thr Ile Ser Gly Arg Cys Gln Cys His Gly His Ala Asp Asn Cys Asp 
        515                 520                 525             
Thr Thr Ser Gln Pro Tyr Arg Cys Leu Cys Ser Gln Glu Ser Phe Thr 
    530                 535                 540                 
Glu Gly Leu His Cys Asp Arg Cys Leu Pro Leu Tyr Asn Asp Lys Pro 
545                 550                 555                 560 
Phe Arg Gln Gly Asp Gln Val Tyr Ala Phe Asn Cys Lys Pro Cys Gln 
                565                 570                 575     
Cys Asn Ser His Ser Lys Ser Cys His Tyr Asn Ile Ser Val Asp Pro 
            580                 585                 590         
Phe Pro Phe Glu His Phe Arg Gly Gly Gly Gly Val Cys Asp Asp Cys 
        595                 600                 605             
Glu His Asn Thr Thr Gly Arg Asn Cys Glu Leu Cys Lys Asp Tyr Phe 
    610                 615                 620                 
Phe Arg Gln Val Gly Ala Asp Pro Ser Ala Ile Asp Val Cys Lys Pro 
625                 630                 635                 640 
Cys Asp Cys Asp Thr Val Gly Thr Arg Asn Gly Ser Ile Leu Cys Asp 
                645                 650                 655     
Gln Ile Gly Gly Gln Cys Asn Cys Lys Arg His Val Ser Gly Arg Gln 
            660                 665                 670         
Cys Asn Gln Cys Gln Asn Gly Phe Tyr Asn Leu Gln Glu Leu Asp Pro 
        675                 680                 685             
Asp Gly Cys Ser Pro Cys Asn Cys Asn Thr Ser Gly Thr Val Asp Gly 
    690                 695                 700                 
Asp Ile Thr Cys His Gln Asn Ser Gly Gln Cys Lys Cys Lys Ala Asn 
705                 710                 715                 720 
Val Ile Gly Leu Arg Cys Asp His Cys Asn Phe Gly Phe Lys Phe Leu 
                725                 730                 735     
Arg Ser Phe Asn Asp Val Gly Cys Glu Pro Cys Gln Cys Asn Leu His 
            740                 745                 750         
Gly Ser Val Asn Lys Phe Cys Asn Pro His Ser Gly Gln Cys Glu Cys 
        755                 760                 765             
Lys Lys Glu Ala Lys Gly Leu Gln Cys Asp Thr Cys Arg Glu Asn Phe 
    770                 775                 780                 
Tyr Gly Leu Asp Val Thr Asn Cys Lys Ala Cys Asp Cys Asp Thr Ala 
785                 790                 795                 800 
Gly Ser Leu Pro Gly Thr Val Cys Asn Ala Lys Thr Gly Gln Cys Ile 
                805                 810                 815     
Cys Lys Pro Asn Val Glu Gly Arg Gln Cys Asn Lys Cys Leu Glu Gly 
            820                 825                 830         
Asn Phe Tyr Leu Arg Gln Asn Asn Ser Phe Leu Cys Leu Pro Cys Asn 
        835                 840                 845             
Cys Asp Lys Thr Gly Thr Ile Asn Gly Ser Leu Leu Cys Asn Lys Ser 
    850                 855                 860                 
Thr Gly Gln Cys Pro Cys Lys Leu Gly Val Thr Gly Leu Arg Cys Asn 
865                 870                 875                 880 
Gln Cys Glu Pro His Arg Tyr Asn Leu Thr Ile Asp Asn Phe Gln His 
                885                 890                 895     
Cys Gln Met Cys Glu Cys Asp Ser Leu Gly Thr Leu Pro Gly Thr Ile 
            900                 905                 910         
Cys Asp Pro Ile Ser Gly Gln Cys Leu Cys Val Pro Asn Arg Gln Gly 
        915                 920                 925             
Arg Arg Cys Asn Gln Cys Gln Pro Gly Phe Tyr Ile Ser Pro Gly Asn 
    930                 935                 940                 
Ala Thr Gly Cys Leu Pro Cys Ser Cys His Thr Thr Gly Ala Val Asn 
945                 950                 955                 960 
His Ile Cys Asn Ser Leu Thr Gly Gln Cys Val Cys Gln Asp Ala Ser 
                965                 970                 975     
Ile Ala Gly Gln Arg Cys Asp Gln Cys Lys Asp His Tyr Phe Gly Phe 
            980                 985                 990         
Asp Pro Gln Thr Gly Arg Cys Gln Pro Cys Asn Cys His Leu Ser Gly 
        995                 1000                1005            
Ala Leu Asn Glu Thr Cys His Leu Val Thr Gly Gln Cys Phe Cys Lys 
    1010                1015                1020                
Gln Phe Val Thr Gly Ser Lys Cys Asp Ala Cys Val Pro Ser Ala Ser 
1025                1030                1035                1040
His Leu Asp Val Asn Asn Leu Leu Gly Cys Ser Lys Thr Pro Phe Gln 
                1045                1050                1055    
Gln Pro Pro Pro Arg Gly Gln Val Gln Ser Ser Ser Ala Ile Asn Leu 
            1060                1065                1070        
Ser Trp Ser Pro Pro Asp Ser Pro Asn Ala His Trp Leu Thr Tyr Ser 
        1075                1080                1085            
Leu Leu Arg Asp Gly Phe Glu Ile Tyr Thr Thr Glu Asp Gln Tyr Pro 
    1090                1095                1100                
Tyr Ser Ile Gln Tyr Phe Leu Asp Thr Asp Leu Leu Pro Tyr Thr Lys 
1105                1110                1115                1120
Tyr Ser Tyr Tyr Ile Glu Thr Thr Asn Val His Gly Ser Thr Arg Ser 
                1125                1130                1135    
Val Ala Val Thr Tyr Lys Thr Lys Pro Gly Val Pro Glu Gly Asn Leu 
            1140                1145                1150        
Thr Leu Ser Tyr Ile Ile Pro Ile Gly Ser Asp Ser Val Thr Leu Thr 
        1155                1160                1165            
Trp Thr Thr Leu Ser Asn Gln Ser Gly Pro Ile Glu Lys Tyr Ile Leu 
    1170                1175                1180                
Ser Cys Ala Pro Leu Ala Gly Gly Gln Pro Cys Val Ser Tyr Glu Gly 
1185                1190                1195                1200
His Glu Thr Ser Ala Thr Ile Trp Asn Leu Val Pro Phe Ala Lys Tyr 
                1205                1210                1215    
Asp Phe Ser Val Gln Ala Cys Thr Ser Gly Gly Cys Leu His Ser Leu 
            1220                1225                1230        
Pro Ile Thr Val Thr Thr Ala Gln Ala Pro Pro Gln Arg Leu Ser Pro 
        1235                1240                1245            
Pro Lys Met Gln Lys Ile Ser Ser Thr Glu Leu His Val Glu Trp Ser 
    1250                1255                1260                
Pro Pro Ala Glu Leu Asn Gly Ile Ile Ile Arg Tyr Glu Leu Tyr Met 
1265                1270                1275                1280
Arg Arg Leu Arg Ser Thr Lys Glu Thr Thr Ser Glu Glu Ser Arg Val 
                1285                1290                1295    
Phe Gln Ser Ser Gly Trp Leu Ser Pro His Ser Phe Val Glu Ser Ala 
            1300                1305                1310        
Asn Glu Asn Ala Leu Lys Pro Pro Gln Thr Met Thr Thr Ile Thr Gly 
        1315                1320                1325            
Leu Glu Pro Tyr Thr Lys Tyr Glu Phe Arg Val Leu Ala Val Asn Met 
    1330                1335                1340                
Ala Gly Ser Val Ser Ser Ala Trp Val Ser Glu Arg Thr Gly Glu Ser 
1345                1350                1355                1360
Ala Pro Val Phe Met Ile Pro Pro Ser Val Phe Pro Leu Ser Ser Tyr 
                1365                1370                1375    
Ser Leu Asn Ile Ser Trp Glu Lys Pro Ala Asp Asn Val Thr Arg Gly 
            1380                1385                1390        
Lys Val Val Gly Tyr Asp Ile Asn Met Leu Ser Glu Gln Ser Pro Gln 
        1395                1400                1405            
Gln Ser Ile Pro Met Ala Phe Ser Gln Leu Leu His Thr Ala Lys Ser 
    1410                1415                1420                
Gln Glu Leu Ser Tyr Thr Val Glu Gly Leu Lys Pro Tyr Arg Ile Tyr 
1425                1430                1435                1440
Glu Phe Thr Ile Thr Leu Cys Asn Ser Val Gly Cys Val Thr Ser Ala 
                1445                1450                1455    
Ser Gly Ala Gly Gln Thr Leu Ala Ala Ala Pro Ala Gln Leu Arg Pro 
            1460                1465                1470        
Pro Leu Val Lys Gly Ile Asn Ser Thr Thr Ile His Leu Arg Trp Phe 
        1475                1480                1485            
Pro Pro Glu Glu Leu Asn Gly Pro Ser Pro Ile Tyr Gln Leu Glu Arg 
    1490                1495                1500                
Arg Glu Ser Ser Leu Pro Ala Leu Met Thr Thr Met Met Lys Gly Ile 
1505                1510                1515                1520
Arg Phe Ile Gly Asn Gly Tyr Cys Lys Phe Pro Ser Ser Thr His Pro 
                1525                1530                1535    
Val Asn Thr Asp Phe Thr Gly Ile Lys Ala Ser Phe Arg Thr Lys Val 
            1540                1545                1550        
Pro Glu Gly Leu Ile Val Phe Ala Ala Ser Pro Gly Asn Gln Glu Glu 
        1555                1560                1565            
Tyr Phe Ala Leu Gln Leu Lys Lys Gly Arg Leu Tyr Phe Leu Phe Asp 
    1570                1575                1580                
Pro Gln Gly Ser Pro Val Glu Val Thr Thr Thr Asn Asp His Gly Lys 
1585                1590                1595                1600
Gln Tyr Ser Asp Gly Lys Trp His Glu Ile Ile Ala Ile Arg His Gln 
                1605                1610                1615    
Ala Phe Gly Gln Ile Thr Leu Asp Gly Ile Tyr Thr Gly Ser Ser Ala 
            1620                1625                1630        
Ile Leu Asn Gly Ser Thr Val Ile Gly Asp Asn Thr Gly Val Phe Leu 
        1635                1640                1645            
Gly Gly Leu Pro Arg Ser Tyr Thr Ile Leu Arg Lys Asp Pro Glu Ile 
    1650                1655                1660                
Ile Gln Lys Gly Phe Val Gly Cys Leu Lys Asp Val His Phe Met Lys 
1665                1670                1675                1680
Asn Tyr Asn Pro Ser Ala Ile Trp Glu Pro Leu Asp Trp Gln Ser Ser 
                1685                1690                1695    
Glu Glu Gln Ile Asn Val Tyr Asn Ser Trp Glu Gly Cys Pro Ala Ser 
            1700                1705                1710        
Leu Asn Glu Gly Ala Gln Phe Leu Gly Ala Gly Phe Leu Glu Leu His 
        1715                1720                1725            
Pro Tyr Met Phe His Gly Gly Met Asn Phe Glu Ile Ser Phe Lys Phe 
    1730                1735                1740                
Arg Thr Asp Gln Leu Asn Gly Leu Leu Leu Phe Val Tyr Asn Lys Asp 
1745                1750                1755                1760
Gly Pro Asp Phe Leu Ala Met Glu Leu Lys Ser Gly Ile Leu Thr Phe 
                1765                1770                1775    
Arg Leu Asn Thr Ser Leu Ala Phe Thr Gln Val Asp Leu Leu Leu Gly 
            1780                1785                1790        
Leu Ser Tyr Cys Asn Gly Lys Trp Asn Lys Val Ile Ile Lys Lys Glu 
        1795                1800                1805            
Gly Ser Phe Ile Ser Ala Ser Val Asn Gly Leu Met Lys His Ala Ser 
    1810                1815                1820                
Glu Ser Gly Asp Gln Pro Leu Val Val Asn Ser Pro Val Tyr Val Gly 
1825                1830                1835                1840
Gly Ile Pro Gln Glu Leu Leu Asn Ser Tyr Gln His Leu Cys Leu Glu 
                1845                1850                1855    
Gln Gly Phe Gly Gly Cys Met Lys Asp Val Lys Phe Thr Arg Gly Ala 
            1860                1865                1870        
Val Val Asn Leu Ala Ser Val Ser Ser Gly Ala Val Arg Val Asn Leu 
        1875                1880                1885            
Asp Gly Cys Leu Ser Thr Asp Ser Ala Val Asn Cys Arg Gly Asn Asp 
    1890                1895                1900                
Ser Ile Leu Val Tyr Gln Gly Lys Glu Gln Ser Val Tyr Glu Gly Gly 
1905                1910                1915                1920
Leu Gln Pro Phe Thr Glu Tyr Leu Tyr Arg Val Ile Ala Ser His Glu 
                1925                1930                1935    
Gly Gly Ser Val Tyr Ser Asp Trp Ser Arg Gly Arg Thr Thr Gly Ala 
            1940                1945                1950        
Ala Pro Gln Ser Val Pro Thr Pro Ser Arg Val Arg Ser Leu Asn Gly 
        1955                1960                1965            
Tyr Ser Ile Glu Val Thr Trp Asp Glu Pro Val Val Arg Gly Val Ile 
    1970                1975                1980                
Glu Lys Tyr Ile Leu Lys Ala Tyr Ser Glu Asp Ser Thr Arg Pro Pro 
1985                1990                1995                2000
Arg Met Pro Ser Ala Ser Ala Glu Phe Val Asn Thr Ser Asn Leu Thr 
                2005                2010                2015    
Gly Ile Leu Thr Gly Leu Leu Pro Phe Lys Asn Tyr Ala Val Thr Leu 
            2020                2025                2030        
Thr Ala Cys Thr Leu Ala Gly Cys Thr Glu Ser Ser His Ala Leu Asn 
        2035                2040                2045            
Ile Ser Thr Pro Gln Glu Ala Pro Gln Glu Val Gln Pro Pro Val Ala 
    2050                2055                2060                
Lys Ser Leu Pro Ser Ser Leu Leu Leu Ser Trp Asn Pro Pro Lys Lys 
2065                2070                2075                2080
Ala Asn Gly Ile Ile Thr Gln Tyr Cys Leu Tyr Met Asp Gly Arg Leu 
                2085                2090                2095    
Ile Tyr Ser Gly Ser Glu Glu Asn Tyr Ile Val Thr Asp Leu Ala Val 
            2100                2105                2110        
Phe Thr Pro His Gln Phe Leu Leu Ser Ala Cys Thr His Val Gly Cys 
        2115                2120                2125            
Thr Asn Ser Ser Trp Val Leu Leu Tyr Thr Ala Gln Leu Pro Pro Glu 
    2130                2135                2140                
His Val Asp Ser Pro Val Leu Thr Val Leu Asp Ser Arg Thr Ile His 
2145                2150                2155                2160
Ile Gln Trp Lys Gln Pro Arg Lys Ile Ser Gly Ile Leu Glu Arg Tyr 
                2165                2170                2175    
Val Leu Tyr Met Ser Asn His Thr His Asp Phe Thr Ile Trp Ser Val 
            2180                2185                2190        
Ile Tyr Asn Ser Thr Glu Leu Phe Gln Asp His Met Leu Gln Tyr Val 
        2195                2200                2205            
Leu Pro Gly Asn Lys Tyr Leu Ile Lys Leu Gly Ala Cys Thr Gly Gly 
    2210                2215                2220                
Gly Cys Thr Val Ser Glu Ala Ser Glu Ala Leu Thr Asp Glu Asp Ile 
2225                2230                2235                2240
Pro Glu Gly Val Pro Ala Pro Lys Ala His Ser Tyr Ser Pro Asp Ser 
                2245                2250                2255    
Phe Asn Val Ser Trp Thr Glu Pro Glu Tyr Pro Asn Gly Val Ile Thr 
            2260                2265                2270        
Ser Tyr Gly Leu Tyr Leu Asp Gly Ile Leu Ile His Asn Ser Ser Glu 
        2275                2280                2285            
Leu Ser Tyr Arg Ala Tyr Gly Phe Ala Pro Trp Ser Leu His Ser Phe 
    2290                2295                2300                
Arg Val Gln Ala Cys Thr Ala Lys Gly Cys Ala Leu Gly Pro Leu Val 
2305                2310                2315                2320
Glu Asn Arg Thr Leu Glu Ala Pro Pro Glu Gly Thr Val Asn Val Phe 
                2325                2330                2335    
Val Lys Thr Gln Gly Ser Arg Lys Ala His Val Arg Trp Glu Ala Pro 
            2340                2345                2350        
Phe Arg Pro Asn Gly Leu Leu Thr His Ser Val Leu Phe Thr Gly Ile 
        2355                2360                2365            
Phe Tyr Val Asp Pro Val Gly Asn Asn Tyr Thr Leu Leu Asn Val Thr 
    2370                2375                2380                
Lys Val Met Tyr Ser Gly Glu Glu Thr Asn Leu Trp Val Leu Ile Asp 
2385                2390                2395                2400
Gly Leu Val Pro Phe Thr Asn Tyr Thr Val Gln Val Asn Ile Ser Asn 
                2405                2410                2415    
Ser Gln Gly Ser Leu Ile Thr Asp Pro Ile Thr Ile Ala Met Pro Pro 
            2420                2425                2430        
Gly Ala Pro Asp Gly Val Leu Pro Pro Arg Leu Ser Ser Ala Thr Pro 
        2435                2440                2445            
Thr Ser Leu Gln Val Val Trp Ser Thr Pro Ala Arg Asn Asn Ala Pro 
    2450                2455                2460                
Gly Ser Pro Arg Tyr Gln Leu Gln Met Arg Ser Gly Asp Ser Thr His 
2465                2470                2475                2480
Gly Phe Leu Glu Leu Phe Ser Asn Pro Ser Ala Ser Leu Ser Tyr Glu 
                2485                2490                2495    
Val Ser Asp Leu Gln Pro Tyr Thr Glu Tyr Met Phe Arg Leu Val Ala 
            2500                2505                2510        
Ser Asn Gly Phe Gly Ser Ala His Ser Ser Trp Ile Pro Phe Met Thr 
        2515                2520                2525            
Ala Glu Asp Lys Pro Gly Pro Val Val Pro Pro Ile Leu Leu Asp Val 
    2530                2535                2540                
Lys Ser Arg Met Met Leu Val Thr Trp Gln His Pro Arg Lys Ser Asn 
2545                2550                2555                2560
Gly Val Ile Thr His Tyr Asn Ile Tyr Leu His Gly Arg Leu Tyr Leu 
                2565                2570                2575    
Arg Thr Pro Gly Asn Val Thr Asn Cys Thr Val Met His Leu His Pro 
            2580                2585                2590        
Tyr Thr Ala Tyr Lys Phe Gln Val Glu Ala Cys Thr Ser Lys Gly Cys 
        2595                2600                2605            
Ser Leu Ser Pro Glu Ser Gln Thr Val Trp Thr Leu Pro Gly Ala Pro 
    2610                2615                2620                
Glu Gly Ile Pro Ser Pro Glu Leu Phe Ser Asp Thr Pro Thr Ser Val 
2625                2630                2635                2640
Ile Ile Ser Trp Gln Pro Pro Thr His Pro Asn Gly Leu Val Glu Asn 
                2645                2650                2655    
Phe Thr Ile Glu Arg Arg Val Lys Gly Lys Glu Glu Val Thr Thr Leu 
            2660                2665                2670        
Val Thr Leu Pro Arg Ser His Ser Met Arg Phe Ile Asp Lys Thr Ser 
        2675                2680                2685            
Ala Leu Ser Pro Trp Thr Lys Tyr Glu Tyr Arg Val Leu Met Ser Thr 
    2690                2695                2700                
Leu His Gly Gly Thr Asn Ser Ser Ala Trp Val Glu Val Thr Thr Arg 
2705                2710                2715                2720
Pro Ser Arg Pro Ala Gly Val Gln Pro Pro Val Val Thr Val Leu Glu 
                2725                2730                2735    
Pro Asp Ala Val Gln Val Thr Trp Lys Pro Pro Leu Ile Gln Asn Gly 
            2740                2745                2750        
Asp Ile Leu Ser Tyr Glu Ile His Met Pro Asp Pro His Ile Thr Leu 
        2755                2760                2765            
Thr Asn Val Thr Ser Ala Val Leu Ser Gln Lys Val Thr His Leu Ile 
    2770                2775                2780                
Pro Phe Thr Asn Tyr Ser Val Thr Ile Val Ala Cys Ser Gly Gly Asn 
2785                2790                2795                2800
Gly Tyr Leu Gly Gly Cys Thr Glu Ser Leu Pro Thr Tyr Val Thr Thr 
                2805                2810                2815    
His Pro Thr Val Pro Gln Asn Val Gly Pro Leu Ser Val Ile Pro Leu 
            2820                2825                2830        
Ser Glu Ser Tyr Val Val Ile Ser Trp Gln Pro Pro Ser Lys Pro Asn 
        2835                2840                2845            
Gly Pro Asn Leu Arg Tyr Glu Leu Leu Arg Arg Lys Ile Gln Gln Pro 
    2850                2855                2860                
Leu Ala Ser Asn Pro Pro Glu Asp Leu Asn Arg Trp His Asn Ile Tyr 
2865                2870                2875                2880
Ser Gly Thr Gln Trp Leu Tyr Glu Asp Lys Gly Leu Ser Arg Phe Thr 
                2885                2890                2895    
Thr Tyr Glu Tyr Met Leu Phe Val His Asn Ser Val Gly Phe Thr Pro 
            2900                2905                2910        
Ser Arg Glu Val Thr Val Thr Thr Leu Ala Gly Leu Pro Glu Arg Gly 
        2915                2920                2925            
Ala Asn Leu Thr Ala Ser Val Leu Asn His Thr Ala Ile Asp Val Arg 
    2930                2935                2940                
Trp Ala Lys Pro Thr Val Gln Asp Leu Gln Gly Glu Val Glu Tyr Tyr 
2945                2950                2955                2960
Thr Leu Phe Trp Ser Ser Ala Thr Ser Asn Asp Ser Leu Lys Ile Leu 
                2965                2970                2975    
Pro Asp Val Asn Ser His Val Ile Gly His Leu Lys Pro Asn Thr Glu 
            2980                2985                2990        
Tyr Trp Ile Phe Ile Ser Val Phe Asn Gly Val His Ser Ile Asn Ser 
        2995                3000                3005            
Ala Gly Leu His Ala Thr Thr Cys Asp Gly Glu Pro Gln Gly Met Leu 
    3010                3015                3020                
Pro Pro Glu Val Val Ile Ile Asn Ser Thr Ala Val Arg Val Ile Trp 
3025                3030                3035                3040
Thr Ser Pro Ser Asn Pro Asn Gly Val Val Thr Glu Tyr Ser Ile Tyr 
                3045                3050                3055    
Val Asn Asn Lys Leu Tyr Lys Thr Gly Met Asn Val Pro Gly Ser Phe 
            3060                3065                3070        
Ile Leu Arg Asp Leu Ser Pro Phe Thr Ile Tyr Asp Ile Gln Val Glu 
        3075                3080                3085            
Val Cys Thr Ile Tyr Ala Cys Val Lys Ser Asn Gly Thr Gln Ile Thr 
    3090                3095                3100                
Thr Val Glu Asp Thr Pro Ser Asp Ile Pro Thr Pro Thr Ile Arg Gly 
3105                3110                3115                3120
Ile Thr Ser Arg Ser Leu Gln Ile Asp Trp Val Ser Pro Arg Lys Pro 
                3125                3130                3135    
Asn Gly Ile Ile Leu Gly Tyr Asp Leu Leu Trp Lys Thr Trp Tyr Pro 
            3140                3145                3150        
Cys Ala Lys Thr Gln Lys Leu Val Gln Asp Gln Ser Asp Glu Leu Cys 
        3155                3160                3165            
Lys Ala Val Arg Cys Gln Lys Pro Glu Ser Ile Cys Gly His Ile Cys 
    3170                3175                3180                
Tyr Ser Ser Glu Ala Lys Val Cys Cys Asn Gly Val Leu Tyr Asn Pro 
3185                3190                3195                3200
Lys Pro Gly His Arg Cys Cys Glu Glu Lys Tyr Ile Pro Phe Val Leu 
                3205                3210                3215    
Asn Ser Thr Gly Val Cys Cys Gly Gly Arg Ile Gln Glu Ala Gln Pro 
            3220                3225                3230        
Asn His Gln Cys Cys Ser Gly Tyr Tyr Ala Arg Ile Leu Pro Gly Glu 
        3235                3240                3245            
Val Cys Cys Pro Asp Glu Gln His Asn Arg Val Ser Val Gly Ile Gly 
    3250                3255                3260                
Asp Ser Cys Cys Gly Arg Met Pro Tyr Ser Thr Ser Gly Asn Gln Ile 
3265                3270                3275                3280
Cys Cys Ala Gly Arg Leu His Asp Gly His Gly Gln Lys Cys Cys Gly 
                3285                3290                3295    
Arg Gln Ile Val Ser Asn Asp Leu Glu Cys Cys Gly Gly Glu Glu Gly 
            3300                3305                3310        
Val Val Tyr Asn Arg Leu Pro Gly Met Phe Cys Cys Gly Gln Asp Tyr 
        3315                3320                3325            
Val Asn Met Ser Asp Thr Ile Cys Cys Ser Ala Ser Ser Gly Glu Ser 
    3330                3335                3340                
Lys Ala His Ile Lys Lys Asn Asp Pro Val Pro Val Lys Cys Cys Glu 
3345                3350                3355                3360
Thr Glu Leu Ile Pro Lys Ser Gln Lys Cys Cys Asn Gly Val Gly Tyr 
                3365                3370                3375    
Asn Pro Leu Lys Tyr Val Cys Ser Asp Lys Ile Ser Thr Gly Met Met 
            3380                3385                3390        
Met Lys Glu Thr Lys Glu Cys Arg Ile Leu Cys Pro Ala Ser Met Glu 
        3395                3400                3405            
Ala Thr Glu His Cys Gly Arg Cys Asp Phe Asn Phe Thr Ser His Ile 
    3410                3415                3420                
Cys Thr Val Ile Arg Gly Ser His Asn Ser Thr Gly Lys Ala Ser Ile 
3425                3430                3435                3440
Glu Glu Met Cys Ser Ser Ala Glu Glu Thr Ile His Thr Gly Ser Val 
                3445                3450                3455    
Asn Thr Tyr Ser Tyr Thr Asp Val Asn Leu Lys Pro Tyr Met Thr Tyr 
            3460                3465                3470        
Glu Tyr Arg Ile Ser Ala Trp Asn Ser Tyr Gly Arg Gly Leu Ser Lys 
        3475                3480                3485            
Ala Val Arg Ala Arg Thr Lys Glu Asp Val Pro Gln Gly Val Ser Pro 
    3490                3495                3500                
Pro Thr Trp Thr Lys Ile Asp Asn Leu Glu Asp Thr Ile Val Leu Asn 
3505                3510                3515                3520
Trp Arg Lys Pro Ile Gln Ser Asn Gly Pro Ile Ile Tyr Tyr Ile Leu 
                3525                3530                3535    
Leu Arg Asn Gly Ile Glu Arg Phe Arg Gly Thr Ser Leu Ser Phe Ser 
            3540                3545                3550        
Asp Lys Glu Gly Ile Gln Pro Phe Gln Glu Tyr Ser Tyr Gln Leu Lys 
        3555                3560                3565            
Ala Cys Thr Val Ala Gly Cys Ala Thr Ser Ser Lys Val Val Ala Ala 
    3570                3575                3580                
Thr Thr Gln Gly Val Pro Glu Ser Ile Leu Pro Pro Ser Ile Thr Ala 
3585                3590                3595                3600
Leu Ser Ala Val Ala Leu His Leu Ser Trp Ser Val Pro Glu Lys Ser 
                3605                3610                3615    
Asn Gly Val Ile Lys Glu Tyr Gln Ile Arg Gln Val Gly Lys Gly Leu 
            3620                3625                3630        
Ile His Thr Asp Thr Thr Asp Arg Arg Gln His Thr Val Thr Gly Leu 
        3635                3640                3645            
Gln Pro Tyr Thr Asn Tyr Ser Phe Thr Leu Thr Ala Cys Thr Ser Ala 
    3650                3655                3660                
Gly Cys Thr Ser Ser Glu Pro Phe Leu Gly Gln Thr Leu Gln Ala Ala 
3665                3670                3675                3680
Pro Glu Gly Val Trp Val Thr Pro Arg His Ile Ile Ile Asn Ser Thr 
                3685                3690                3695    
Thr Val Glu Leu Tyr Trp Ser Leu Pro Glu Lys Pro Asn Gly Leu Val 
            3700                3705                3710        
Ser Gln Tyr Gln Leu Ser Arg Asn Gly Asn Leu Leu Phe Leu Gly Gly 
        3715                3720                3725            
Ser Glu Glu Gln Asn Phe Thr Asp Lys Asn Leu Glu Pro Asn Ser Arg 
    3730                3735                3740                
Tyr Thr Tyr Lys Leu Glu Val Lys Thr Gly Gly Gly Ser Ser Ala Ser 
3745                3750                3755                3760
Asp Asp Tyr Ile Val Gln Thr Pro Met Ser Thr Pro Glu Glu Ile Tyr 
                3765                3770                3775    
Pro Pro Tyr Asn Ile Thr Val Ile Gly Pro Tyr Ser Ile Phe Val Ala 
            3780                3785                3790        
Trp Ile Pro Pro Gly Ile Leu Ile Pro Glu Ile Pro Val Glu Tyr Asn 
        3795                3800                3805            
Val Leu Leu Asn Asp Gly Ser Val Thr Pro Leu Ala Phe Ser Val Gly 
    3810                3815                3820                
His His Gln Ser Thr Leu Leu Glu Asn Leu Thr Pro Phe Thr Gln Tyr 
3825                3830                3835                3840
Glu Ile Arg Ile Gln Ala Cys Gln Asn Gly Ser Cys Gly Val Ser Ser 
                3845                3850                3855    
Arg Met Phe Val Lys Thr Pro Glu Ala Ala Pro Met Asp Leu Asn Ser 
            3860                3865                3870        
Pro Val Leu Lys Ala Leu Gly Ser Ala Cys Ile Glu Ile Lys Trp Met 
        3875                3880                3885            
Pro Pro Glu Lys Pro Asn Gly Ile Ile Ile Asn Tyr Phe Ile Tyr Arg 
    3890                3895                3900                
Arg Pro Ala Gly Ile Glu Glu Glu Ser Val Leu Phe Val Trp Ser Glu 
3905                3910                3915                3920
Gly Ala Leu Glu Phe Met Asp Glu Gly Asp Thr Leu Arg Pro Phe Thr 
                3925                3930                3935    
Leu Tyr Glu Tyr Arg Val Arg Ala Cys Asn Ser Lys Gly Ser Val Glu 
            3940                3945                3950        
Ser Leu Trp Ser Leu Thr Gln Thr Leu Glu Ala Pro Pro Gln Asp Phe 
        3955                3960                3965            
Pro Ala Pro Trp Ala Gln Ala Thr Ser Ala His Ser Val Leu Leu Asn 
    3970                3975                3980                
Trp Thr Lys Pro Glu Ser Pro Asn Gly Ile Ile Ser His Tyr Arg Val 
3985                3990                3995                4000
Val Tyr Gln Glu Arg Pro Asp Asp Pro Thr Phe Asn Ser Pro Thr Val 
                4005                4010                4015    
His Ala Phe Thr Val Lys Gly Thr Ser His Gln Ala His Leu Tyr Gly 
            4020                4025                4030        
Leu Glu Pro Phe Thr Thr Tyr Arg Ile Gly Val Val Ala Ala Asn His 
        4035                4040                4045            
Ala Gly Glu Ile Leu Ser Pro Trp Thr Leu Ile Gln Thr Leu Glu Ser 
    4050                4055                4060                
Ser Pro Ser Gly Leu Arg Asn Phe Ile Val Glu Gln Lys Glu Asn Gly 
4065                4070                4075                4080
Arg Ala Leu Leu Leu Gln Trp Ser Glu Pro Met Arg Thr Asn Gly Val 
                4085                4090                4095    
Ile Lys Thr Tyr Asn Ile Phe Ser Asp Gly Phe Leu Glu Tyr Ser Gly 
            4100                4105                4110        
Leu Asn Arg Gln Phe Leu Phe Arg Arg Leu Asp Pro Phe Thr Leu Tyr 
        4115                4120                4125            
Thr Leu Thr Leu Glu Ala Cys Thr Arg Ala Gly Cys Ala His Ser Ala 
    4130                4135                4140                
Pro Gln Pro Leu Trp Thr Asp Glu Ala Pro Pro Asp Ser Gln Leu Ala 
4145                4150                4155                4160
Pro Thr Val His Ser Val Lys Ser Thr Ser Val Glu Leu Ser Trp Ser 
                4165                4170                4175    
Glu Pro Val Asn Pro Asn Gly Lys Ile Ile Arg Tyr Glu Val Ile Arg 
            4180                4185                4190        
Arg Cys Phe Glu Gly Lys Ala Trp Gly Asn Gln Thr Ile Gln Ala Asp 
        4195                4200                4205            
Glu Lys Ile Val Phe Thr Glu Tyr Asn Thr Glu Arg Asn Thr Phe Met 
    4210                4215                4220                
Tyr Asn Asp Thr Gly Leu Gln Pro Trp Thr Gln Cys Glu Tyr Lys Ile 
4225                4230                4235                4240
Tyr Thr Trp Asn Ser Ala Gly His Thr Cys Ser Ser Trp Asn Val Val 
                4245                4250                4255    
Arg Thr Leu Gln Ala Pro Pro Glu Gly Leu Ser Pro Pro Val Ile Ser 
            4260                4265                4270        
Tyr Val Ser Met Asn Pro Gln Lys Leu Leu Ile Ser Trp Ile Pro Pro 
        4275                4280                4285            
Glu Gln Ser Asn Gly Ile Ile Gln Ser Tyr Arg Leu Gln Arg Asn Glu 
    4290                4295                4300                
Met Leu Tyr Pro Phe Ser Phe Asp Pro Val Thr Phe Asn Tyr Thr Asp 
4305                4310                4315                4320
Glu Glu Leu Leu Pro Phe Ser Thr Tyr Ser Tyr Ala Leu Gln Ala Cys 
                4325                4330                4335    
Thr Ser Gly Gly Cys Ser Thr Ser Lys Pro Thr Ser Ile Thr Thr Leu 
            4340                4345                4350        
Glu Ala Ala Pro Ser Glu Val Ser Pro Pro Asp Leu Trp Ala Val Ser 
        4355                4360                4365            
Ala Thr Gln Met Asn Val Cys Trp Ser Pro Pro Thr Val Gln Asn Gly 
    4370                4375                4380                
Lys Ile Thr Lys Tyr Leu Val Arg Tyr Asp Asn Lys Glu Ser Leu Ala 
4385                4390                4395                4400
Gly Gln Gly Leu Cys Leu Leu Val Ser His Leu Gln Pro Tyr Ser Gln 
                4405                4410                4415    
Tyr Asn Phe Ser Leu Val Ala Cys Thr Asn Gly Gly Cys Thr Ala Ser 
            4420                4425                4430        
Val Ser Lys Ser Ala Trp Thr Met Glu Ala Leu Pro Glu Asn Met Asp 
        4435                4440                4445            
Ser Pro Thr Leu Gln Val Thr Gly Ser Glu Ser Ile Glu Ile Thr Trp 
    4450                4455                4460                
Lys Pro Pro Arg Asn Pro Asn Gly Gln Ile Arg Ser Tyr Glu Leu Arg 
4465                4470                4475                4480
Arg Asp Gly Thr Ile Val Tyr Thr Gly Leu Glu Thr Arg Tyr Arg Asp 
                4485                4490                4495    
Phe Thr Leu Thr Pro Gly Val Glu Tyr Ser Tyr Thr Val Thr Ala Ser 
            4500                4505                4510        
Asn Ser Gln Gly Gly Ile Leu Ser Pro Leu Val Lys Asp Arg Thr Ser 
        4515                4520                4525            
Pro Ser Ala Pro Ser Gly Met Glu Pro Pro Lys Leu Gln Ala Arg Gly 
    4530                4535                4540                
Pro Gln Glu Ile Leu Val Asn Trp Asp Pro Pro Val Arg Thr Asn Gly 
4545                4550                4555                4560
Asp Ile Ile Asn Tyr Thr Leu Phe Ile Arg Glu Leu Phe Glu Arg Glu 
                4565                4570                4575    
Thr Lys Ile Ile His Ile Asn Thr Thr His Asn Ser Phe Gly Met Gln 
            4580                4585                4590        
Ser Tyr Ile Val Asn Gln Leu Lys Pro Phe His Arg Tyr Glu Ile Arg 
        4595                4600                4605            
Ile Gln Ala Cys Thr Thr Leu Gly Cys Ala Ser Ser Asp Trp Thr Phe 
    4610                4615                4620                
Ile Gln Thr Pro Glu Ile Ala Pro Leu Met Gln Pro Pro Pro His Leu 
4625                4630                4635                4640
Glu Val Gln Met Ala Pro Gly Gly Phe Gln Pro Thr Val Ser Leu Leu 
                4645                4650                4655    
Trp Thr Gly Pro Leu Gln Pro Asn Gly Lys Val Leu Tyr Tyr Glu Leu 
            4660                4665                4670        
Tyr Arg Arg Gln Ile Ala Thr Gln Pro Arg Lys Ser Asn Pro Val Leu 
        4675                4680                4685            
Ile Tyr Asn Gly Ser Ser Thr Ser Phe Ile Asp Ser Glu Leu Leu Pro 
    4690                4695                4700                
Phe Thr Glu Tyr Glu Tyr Gln Val Trp Ala Val Asn Ser Ala Gly Lys 
4705                4710                4715                4720
Ala Pro Ser Ser Trp Thr Trp Cys Arg Thr Gly Pro Ala Pro Pro Glu 
                4725                4730                4735    
Gly Leu Arg Ala Pro Thr Phe His Val Ile Ser Ser Thr Gln Ala Val 
            4740                4745                4750        
Val Asn Ile Ser Ala Pro Gly Lys Pro Asn Gly Ile Val Ser Leu Tyr 
        4755                4760                4765            
Arg Leu Phe Ser Ser Ser Ala His Gly Ala Glu Thr Val Leu Ser Glu 
    4770                4775                4780                
Gly Met Ala Thr Gln Gln Thr Leu His Gly Leu Gln Ala Phe Thr Asn 
4785                4790                4795                4800
Tyr Ser Ile Gly Val Glu Ala Cys Thr Cys Phe Asn Cys Cys Ser Lys 
                4805                4810                4815    
Gly Pro Thr Ala Glu Leu Arg Thr His Pro Ala Pro Pro Ser Gly Leu 
            4820                4825                4830        
Ser Ser Pro Gln Ile Gly Thr Leu Ala Ser Arg Thr Ala Ser Phe Arg 
        4835                4840                4845            
Trp Ser Pro Pro Met Phe Pro Asn Gly Val Ile His Ser Tyr Glu Leu 
    4850                4855                4860                
Gln Phe His Val Ala Cys Pro Pro Asp Ser Ala Leu Pro Cys Thr Pro 
4865                4870                4875                4880
Ser Gln Ile Glu Thr Lys Tyr Thr Gly Leu Gly Gln Lys Ala Ser Leu 
                4885                4890                4895    
Gly Gly Leu Gln Pro Tyr Thr Thr Tyr Lys Leu Arg Val Val Ala His 
            4900                4905                4910        
Asn Glu Val Gly Ser Thr Ala Ser Glu Trp Ile Ser Phe Thr Thr Gln 
        4915                4920                4925            
Lys Glu Leu Pro Gln Tyr Arg Ala Pro Phe Ser Val Asp Ser Asn Leu 
    4930                4935                4940                
Ser Val Val Cys Val Asn Trp Ser Asp Thr Phe Leu Leu Asn Gly Gln 
4945                4950                4955                4960
Leu Lys Glu Tyr Val Leu Thr Asp Gly Gly Arg Arg Val Tyr Ser Gly 
                4965                4970                4975    
Leu Asp Thr Thr Leu Tyr Ile Pro Arg Thr Ala Asp Lys Thr Phe Phe 
            4980                4985                4990        
Phe Gln Val Ile Cys Thr Thr Asp Glu Gly Ser Val Lys Thr Pro Leu 
        4995                5000                5005            
Ile Gln Tyr Asp Thr Ser Thr Gly Leu Gly Leu Val Leu Thr Thr Pro 
    5010                5015                5020                
Gly Lys Lys Lys Gly Ser Arg Ser Lys Ser Thr Glu Phe Tyr Ser Glu 
5025                5030                5035                5040
Leu Trp Phe Ile Val Leu Met Ala Met Leu Gly Leu Ile Leu Leu Ala 
                5045                5050                5055    
Ile Phe Leu Ser Leu Ile Leu Gln Arg Lys Ile His Lys Glu Pro Tyr 
            5060                5065                5070        
Ile Arg Glu Arg Pro Pro Leu Val Pro Leu Gln Lys Arg Met Ser Pro 
        5075                5080                5085            
Leu Asn Val Tyr Pro Pro Gly Glu Asn His Met Gly Leu Ala Asp Thr 
    5090                5095                5100                
Lys Ile Pro Arg Ser Gly Thr Pro Val Ser Ile Arg Ser Asn Arg Ser 
5105                5110                5115                5120
Ala Cys Val Leu Arg Ile Pro Ser Gln Asn Gln Thr Ser Leu Thr Tyr 
                5125                5130                5135    
Ser Gln Gly Ser Leu His Arg Ser Val Ser Gln Leu Met Asp Ile Gln 
            5140                5145                5150        
Asp Lys Lys Val Leu Met Asp Asn Ser Leu Trp Glu Ala Ile Met Gly 
        5155                5160                5165            
His Asn Ser Gly Leu Tyr Val Asp Glu Glu Asp Leu Met Asn Ala Ile 
    5170                5175                5180                
Lys Asp Phe Ser Ser Val Thr Lys Glu Arg Thr Thr Phe Thr Asp Thr 
5185                5190                5195                5200
His Leu 
        

<210> 51
<211> 4386
<212> DNA
<213> Artificial Sequence


<220> 
<223> SV40 NLS_dCas9_SV40 NLS_VP64

<400> 51
atgagcccca agaagaagag aaaggtggag gccagcgaca agaagtacag catcggcctg       60

gccatcggca ccaactctgt gggctgggcc gtgatcaccg acgagtacaa ggtgcccagc      120

aagaaattca aggtgctggg caacaccgac cggcacagca tcaagaagaa cctgatcgga      180

gccctgctgt tcgacagcgg cgaaacagcc gaggccaccc ggctgaagag aaccgccaga      240

agaagataca ccagacggaa gaaccggatc tgctatctgc aagagatctt cagcaacgag      300

atggccaagg tggacgacag cttcttccac agactggaag agtccttcct ggtggaagag      360

gataagaagc acgagcggca ccccatcttc ggcaacatcg tggacgaggt ggcctaccac      420

gagaagtacc ccaccatcta ccacctgaga aagaaactgg tggacagcac cgacaaggcc      480

gacctgcggc tgatctatct ggccctggcc cacatgatca agttccgggg ccacttcctg      540

atcgagggcg acctgaaccc cgacaacagc gacgtggaca agctgttcat ccagctggtg      600

cagacctaca accagctgtt cgaggaaaac cccatcaacg ccagcggcgt ggacgccaag      660

gccatcctgt ctgccagact gagcaagagc agacggctgg aaaatctgat cgcccagctg      720

cccggcgaga agaagaatgg cctgttcggc aacctgattg ccctgagcct gggcctgacc      780

cccaacttca agagcaactt cgacctggcc gaggatgcca aactgcagct gagcaaggac      840

acctacgacg acgacctgga caacctgctg gcccagatcg gcgaccagta cgccgacctg      900

tttctggccg ccaagaacct gtccgacgcc atcctgctga gcgacatcct gagagtgaac      960

accgagatca ccaaggcccc cctgagcgcc tctatgatca agagatacga cgagcaccac     1020

caggacctga ccctgctgaa agctctcgtg cggcagcagc tgcctgagaa gtacaaagag     1080

attttcttcg accagagcaa gaacggctac gccggctaca ttgacggcgg agccagccag     1140

gaagagttct acaagttcat caagcccatc ctggaaaaga tggacggcac cgaggaactg     1200

ctcgtgaagc tgaacagaga ggacctgctg cggaagcagc ggaccttcga caacggcagc     1260

atcccccacc agatccacct gggagagctg cacgccattc tgcggcggca ggaagatttt     1320

tacccattcc tgaaggacaa ccgggaaaag atcgagaaga tcctgacctt ccgcatcccc     1380

tactacgtgg gccctctggc caggggaaac agcagattcg cctggatgac cagaaagagc     1440

gaggaaacca tcaccccctg gaacttcgag gaagtggtgg acaagggcgc ttccgcccag     1500

agcttcatcg agcggatgac caacttcgat aagaacctgc ccaacgagaa ggtgctgccc     1560

aagcacagcc tgctgtacga gtacttcacc gtgtataacg agctgaccaa agtgaaatac     1620

gtgaccgagg gaatgagaaa gcccgccttc ctgagcggcg agcagaaaaa ggccatcgtg     1680

gacctgctgt tcaagaccaa ccggaaagtg accgtgaagc agctgaaaga ggactacttc     1740

aagaaaatcg agtgcttcga ctccgtggaa atctccggcg tggaagatcg gttcaacgcc     1800

tccctgggca cataccacga tctgctgaaa attatcaagg acaaggactt cctggacaat     1860

gaggaaaacg aggacattct ggaagatatc gtgctgaccc tgacactgtt tgaggacaga     1920

gagatgatcg aggaacggct gaaaacctat gcccacctgt tcgacgacaa agtgatgaag     1980

cagctgaagc ggcggagata caccggctgg ggcaggctga gccggaagct gatcaacggc     2040

atccgggaca agcagtccgg caagacaatc ctggatttcc tgaagtccga cggcttcgcc     2100

aacagaaact tcatgcagct gatccacgac gacagcctga cctttaaaga ggacatccag     2160

aaagcccagg tgtccggcca gggcgatagc ctgcacgagc acattgccaa tctggccggc     2220

agccccgcca ttaagaaggg catcctgcag acagtgaagg tggtggacga gctcgtgaaa     2280

gtgatgggcc ggcacaagcc cgagaacatc gtgatcgaaa tggccagaga gaaccagacc     2340

acccagaagg gacagaagaa cagccgcgag agaatgaagc ggatcgaaga gggcatcaaa     2400

gagctgggca gccagatcct gaaagaacac cccgtggaaa acacccagct gcagaacgag     2460

aagctgtacc tgtactacct gcagaatggg cgggatatgt acgtggacca ggaactggac     2520

atcaaccggc tgtccgacta cgatgtggac gctatcgtgc ctcagagctt tctgaaggac     2580

gactccatcg acaacaaggt gctgaccaga agcgacaaga accggggcaa gagcgacaac     2640

gtgccctccg aagaggtcgt gaagaagatg aagaactact ggcggcagct gctgaacgcc     2700

aagctgatta cccagagaaa gttcgacaat ctgaccaagg ccgagagagg cggcctgagc     2760

gaactggata aggccggctt catcaagaga cagctggtgg aaacccggca gatcacaaag     2820

cacgtggcac agatcctgga ctcccggatg aacactaagt acgacgagaa tgacaagctg     2880

atccgggaag tgaaagtgat caccctgaag tccaagctgg tgtccgattt ccggaaggat     2940

ttccagtttt acaaagtgcg cgagatcaac aactaccacc acgcccacga cgcctacctg     3000

aacgccgtcg tgggaaccgc cctgatcaaa aagtacccta agctggaaag cgagttcgtg     3060

tacggcgact acaaggtgta cgacgtgcgg aagatgatcg ccaagagcga gcaggaaatc     3120

ggcaaggcta ccgccaagta cttcttctac agcaacatca tgaacttttt caagaccgag     3180

attaccctgg ccaacggcga gatccggaag cggcctctga tcgagacaaa cggcgaaacc     3240

ggggagatcg tgtgggataa gggccgggat tttgccaccg tgcggaaagt gctgagcatg     3300

ccccaagtga atatcgtgaa aaagaccgag gtgcagacag gcggcttcag caaagagtct     3360

atcctgccca agaggaacag cgataagctg atcgccagaa agaaggactg ggaccctaag     3420

aagtacggcg gcttcgacag ccccaccgtg gcctattctg tgctggtggt ggccaaagtg     3480

gaaaagggca agtccaagaa actgaagagt gtgaaagagc tgctggggat caccatcatg     3540

gaaagaagca gcttcgagaa gaatcccatc gactttctgg aagccaaggg ctacaaagaa     3600

gtgaaaaagg acctgatcat caagctgcct aagtactccc tgttcgagct ggaaaacggc     3660

cggaagagaa tgctggcctc tgccggcgaa ctgcagaagg gaaacgaact ggccctgccc     3720

tccaaatatg tgaacttcct gtacctggcc agccactatg agaagctgaa gggctccccc     3780

gaggataatg agcagaaaca gctgtttgtg gaacagcaca agcactacct ggacgagatc     3840

atcgagcaga tcagcgagtt ctccaagaga gtgatcctgg ccgacgctaa tctggacaaa     3900

gtgctgtccg cctacaacaa gcaccgggat aagcccatca gagagcaggc cgagaatatc     3960

atccacctgt ttaccctgac caatctggga gcccctgccg ccttcaagta ctttgacacc     4020

accatcgacc ggaagaggta caccagcacc aaagaggtgc tggacgccac cctgatccac     4080

cagagcatca ccggcctgta cgagacacgg atcgacctgt ctcagctggg aggcgacagc     4140

gctggaggag gtggaagcgg aggaggagga agcggaggag gaggtagcgg acctaagaaa     4200

aagaggaagg tggcggccgc tggatccgga cgggctgacg cattggacga ttttgatctg     4260

gatatgctgg gaagtgacgc cctcgatgat tttgaccttg acatgcttgg ttcggatgcc     4320

cttgatgact ttgacctcga catgctcggc agtgacgccc ttgatgattt cgacctggac     4380

atgctg                                                                4386


<210> 52
<211> 1419
<212> DNA
<213> Artificial Sequence


<220> 
<223> MS2-N55K_SV40 NLS_P65_HSF1

<400> 52
atggcttcaa actttactca gttcgtgctc gtggacaatg gtgggacagg ggatgtgaca      60

gtggctcctt ctaatttcgc taatggggtg gcagagtgga tcagctccaa ctcacggagc     120

caggcctaca aggtgacatg cagcgtcagg cagtctagtg cccagaagag aaagtatacc     180

atcaaggtgg aggtccccaa agtggctacc cagacagtgg gcggagtcga actgcctgtc     240

gccgcttgga ggtcctacct gaacatggag ctcactatcc caattttcgc taccaattct     300

gactgtgaac tcatcgtgaa ggcaatgcag gggctcctca aagacggtaa tcctatccct     360

tccgccatcg ccgctaactc aggtatctac agcgctggag gaggtggaag cggaggagga     420

ggaagcggag gaggaggtag cggacctaag aaaaagagga aggtggcggc cgctggatcc     480

ccttcagggc agatcagcaa ccaggccctg gctctggccc ctagctccgc tccagtgctg     540

gcccagacta tggtgccctc tagtgctatg gtgcctctgg cccagccacc tgctccagcc     600

cctgtgctga ccccaggacc accccagtca ctgagcgctc cagtgcccaa gtctacacag     660

gccggcgagg ggactctgag tgaagctctg ctgcacctgc agttcgacgc tgatgaggac     720

ctgggagctc tgctggggaa cagcaccgat cccggagtgt tcacagatct ggcctccgtg     780

gacaactctg agtttcagca gctgctgaat cagggcgtgt ccatgtctca tagtacagcc     840

gaaccaatgc tgatggagta ccccgaagcc attacccggc tggtgaccgg cagccagcgg     900

ccccccgacc ccgctccaac tcccctggga accagcggcc tgcctaatgg gctgtccgga     960

gatgaagact tctcaagcat cgctgatatg gactttagtg ccctgctgtc acagatttcc    1020

tctagtgggc agggaggagg tggaagcggc ttcagcgtgg acaccagtgc cctgctggac    1080

ctgttcagcc cctcggtgac cgtgcccgac atgagcctgc ctgaccttga cagcagcctg    1140

gccagtatcc aagagctcct gtctccccag gagcccccca ggcctcccga ggcagagaac    1200

agcagcccgg attcagggaa gcagctggtg cactacacag cgcagccgct gttcctgctg    1260

gaccccggct ccgtggacac cgggagcaac gacctgccgg tgctgtttga gctgggagag    1320

ggctcctact tctccgaagg ggacggcttc gccgaggacc ccaccatctc cctgctgaca    1380

ggctcggagc ctcccaaagc caaggacccc actgtctcc                           1419


<210> 53
<211> 410
<212> DNA
<213> Artificial Sequence


<220> 
<223> U6-sgRNA MS2 stem loop

<400> 53
gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc tgttagagag      60

ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac gtgacgtaga     120

aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat ggactatcat     180

atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt gtggaaagga     240

cgaaacaccg ggtcttcgag aagacctgtt ttagagctag gccaacatga ggatcaccca     300

tgtctgcagg gcctagcaag ttaaaataag gctagtccgt tatcaacttg gccaacatga     360

ggatcaccca tgtctgcagg gccaagtggc accgagtcgg tgcttttttt                410


<210> 54
<211> 5145
<212> DNA
<213> Artificial Sequence


<220> 
<223> SV40NLS-dCas9-HA-2xSV40NLS-10xGCN4_v4-SV40 NLS

<400> 54
cccaagaaga agcgcaaggt gggacgcgtc tgcaggatat caagcttgcg gtaccgcggg       60

cccgggatcg ccaccatgga caagaagtac agcatcggcc tggccatcgg caccaactct      120

gtgggctggg ccgtgatcac cgacgagtac aaggtgccca gcaagaaatt caaggtgctg      180

ggcaacaccg accggcacag catcaagaag aacctgatcg gcgccctgct gttcgacagc      240

ggagaaacag ccgaggccac ccggctgaag agaaccgcca gaagaagata caccagacgg      300

aagaaccgga tctgctatct gcaagagatc ttcagcaacg agatggccaa ggtggacgac      360

agcttcttcc acagactgga agagtccttc ctggtggaag aggataagaa gcacgagcgg      420

caccccatct tcggcaacat cgtggacgag gtggcctacc acgagaagta ccccaccatc      480

taccacctga gaaagaaact ggtggacagc accgacaagg ccgacctgcg gctgatctat      540

ctggccctgg cccacatgat caagttccgg ggccacttcc tgatcgaggg cgacctgaac      600

cccgacaaca gcgacgtgga caagctgttc atccagctgg tgcagaccta caaccagctg      660

ttcgaggaaa accccatcaa cgccagcggc gtggacgcca aggccatcct gtctgccaga      720

ctgagcaaga gcagacggct ggaaaatctg atcgcccagc tgcccggcga gaagaagaat      780

ggcctgttcg gcaacctgat tgccctgagc ctgggcctga cccccaactt caagagcaac      840

ttcgacctgg ccgaggatgc caaactgcag ctgagcaagg acacctacga cgacgacctg      900

gacaacctgc tggcccagat cggcgaccag tacgccgacc tgtttctggc cgccaagaac      960

ctgtccgacg ccatcctgct gagcgacatc ctgagagtga acaccgagat caccaaggcc     1020

cccctgagcg cctctatgat caagagatac gacgagcacc accaggacct gaccctgctg     1080

aaagctctcg tgcggcagca gctgcctgag aagtacaaag agattttctt cgaccagagc     1140

aagaacggct acgccggcta catcgatggc ggagccagcc aggaagagtt ctacaagttc     1200

atcaagccca tcctggaaaa gatggacggc accgaggaac tgctcgtgaa gctgaacaga     1260

gaggacctgc tgcggaagca gcggaccttc gacaacggca gcatccccca ccagatccac     1320

ctgggagagc tgcacgccat tctgcggcgg caggaagatt tttacccatt cctgaaggac     1380

aaccgggaaa agatcgagaa gatcctgacc ttccgcatcc cctactacgt gggccctctg     1440

gccaggggaa acagcagatt cgcctggatg accagaaaga gcgaggaaac catcaccccc     1500

tggaacttcg aggaagtggt ggacaagggc gccagcgccc agagcttcat cgagcggatg     1560

accaacttcg ataagaacct gcccaacgag aaggtgctgc ccaagcacag cctgctgtac     1620

gagtacttca ccgtgtacaa cgagctgacc aaagtgaaat acgtgaccga gggaatgaga     1680

aagcccgcct tcctgagcgg cgagcagaaa aaagccatcg tggacctgct gttcaagacc     1740

aaccggaaag tgaccgtgaa gcagctgaaa gaggactact tcaagaaaat cgagtgcttc     1800

gactccgtgg aaatctccgg cgtggaagat cggttcaacg cctccctggg cacataccac     1860

gatctgctga aaattatcaa ggacaaggac ttcctggaca atgaggaaaa cgaggacatt     1920

ctggaagata tcgtgctgac cctgacactg tttgaggaca gagagatgat cgaggaacgg     1980

ctgaaaacct atgcccacct gttcgacgac aaagtgatga agcagctgaa gcggcggaga     2040

tacaccggct ggggcaggct gagccggaag ctgatcaacg gcatccggga caagcagtcc     2100

ggcaagacaa tcctggattt cctgaagtcc gacggcttcg ccaacagaaa cttcatgcag     2160

ctgatccacg acgacagcct gacctttaaa gaggacatcc agaaagccca ggtgtccggc     2220

cagggcgata gcctgcacga gcacattgcc aatctggccg gcagccccgc cattaagaag     2280

ggcatcctgc agacagtgaa ggtggtggac gagctcgtga aagtgatggg ccggcacaag     2340

cccgagaaca tcgtgatcga aatggccaga gagaaccaga ccacccagaa gggacagaag     2400

aacagccgcg agagaatgaa gcggatcgaa gagggcatca aagagctggg cagccagatc     2460

ctgaaagaac accccgtgga aaacacccag ctgcagaacg agaagctgta cctgtactac     2520

ctgcagaatg ggcgggatat gtacgtggac caggaactgg acatcaaccg gctgtccgac     2580

tacgatgtgg acgctatcgt gcctcagagc tttctgaagg acgactccat cgataacaaa     2640

gtgctgactc ggagcgacaa gaaccggggc aagagcgaca acgtgccctc cgaagaggtc     2700

gtgaagaaga tgaagaacta ctggcgccag ctgctgaatg ccaagctgat tacccagagg     2760

aagttcgaca atctgaccaa ggccgagaga ggcggcctga gcgaactgga taaggccggc     2820

ttcatcaaga gacagctggt ggaaacccgg cagatcacaa agcacgtggc acagatcctg     2880

gactcccgga tgaacactaa gtacgacgag aacgacaaac tgatccggga agtgaaagtg     2940

atcaccctga agtccaagct ggtgtccgat ttccggaagg atttccagtt ttacaaagtg     3000

cgcgagatca acaactacca ccacgcccac gacgcctacc tgaacgccgt cgtgggaacc     3060

gccctgatca aaaagtaccc taagctggaa agcgagttcg tgtacggcga ctacaaggtg     3120

tacgacgtgc ggaagatgat cgccaagagc gagcaggaaa tcggcaaggc taccgccaag     3180

tacttcttct acagcaacat catgaacttt ttcaagaccg agattaccct ggccaacggc     3240

gagatccgga agcggcctct gatcgagaca aacggcgaaa caggcgagat cgtgtgggat     3300

aagggccggg actttgccac cgtgcggaaa gtgctgtcta tgccccaagt gaatatcgtg     3360

aaaaagaccg aggtgcagac aggcggcttc agcaaagagt ctatcctgcc caagaggaac     3420

agcgacaagc tgatcgccag aaagaaggac tgggacccta agaagtacgg cggcttcgac     3480

agccccaccg tggcctattc tgtgctggtg gtggccaaag tggaaaaggg caagtccaag     3540

aaactgaaga gtgtgaaaga gctgctgggg atcaccatca tggaaagaag cagcttcgag     3600

aagaatccca tcgactttct ggaagccaag ggctacaaag aagtgaaaaa ggacctgatc     3660

atcaagctgc ctaagtactc cctgttcgag ctggaaaacg gccggaagag aatgctggcc     3720

tctgccggcg aactgcagaa gggaaacgaa ctggccctgc cctccaaata tgtgaacttc     3780

ctgtacctgg ccagccacta tgagaagctg aagggctccc ccgaggataa tgagcagaaa     3840

cagctgtttg tggaacagca caaacactac ctggacgaga tcatcgagca gatcagcgag     3900

ttctccaaga gagtgatcct ggccgacgct aatctggaca aggtgctgag cgcctacaac     3960

aagcacagag acaagcctat cagagagcag gccgagaata tcatccacct gtttaccctg     4020

accaatctgg gagcccctgc cgccttcaag tactttgaca ccaccatcga ccggaagagg     4080

tacaccagca ccaaagaggt gctggacgcc accctgatcc accagagcat caccggcctg     4140

tacgagacac ggatcgacct gtctcagctg ggaggcgacg cctatcccta tgacgtgccc     4200

gattatgcca gcctgggcag cggctccccc aagaaaaaac gcaaggtgga agatcctaag     4260

aaaaagcgga aagtggacgg cattggtagt gggagcaacg gcagcagcgg atccaacggt     4320

ccgactgacg ccgcggaaga agaacttttg agcaagaatt atcatcttga gaacgaagtg     4380

gctcgtctta agaaaggttc tggcagtgga gaagaactgc tttcaaagaa ttaccacctg     4440

gaaaatgagg tagctagact gaaaaagggg agcggaagtg gggaggagtt gctgagcaaa     4500

aattatcatt tggagaacga agtagcacga ctaaagaaag ggtccggatc gggtgaggag     4560

ttactctcga aaaattatca tctcgaaaac gaagtggctc ggctaaaaaa gggcagtggt     4620

tctggagaag agctattatc taaaaactac cacctcgaaa atgaggtggc acgcttaaaa     4680

aagggaagtg gcagtggtga agagctacta tccaagaatt atcatcttga gaacgaggta     4740

gcgcgtttga agaagggttc cggctcagga gaggaactgc tctcgaagaa ctatcatctt     4800

gaaaatgagg tcgctcgatt aaaaaaggga tcgggcagtg gtgaggaact actttcaaag     4860

aattaccacc tcgaaaacga agtagctcga ttaaagaaag gttcagggtc gggtgaagaa     4920

ttactgagta aaaattatca tctggaaaat gaggtagcga gactaaaaaa ggggagtggt     4980

tctggcgagg aattgctatc gaaaaattat catcttgaga acgaagttgc taggctcaaa     5040

aagggctcag gctcaggcac cgcggtaaac ataggtggtg gaaccggtcc gatggatcta     5100

cagcggccgc aaggtggagg tggacccaag aagaagcgca aggtg                     5145


<210> 55
<211> 2034
<212> DNA
<213> Artificial Sequence


<220> 
<223> scFv-GCN4-sfGFP-VP64-GB1-RexNLS

<400> 55
atgggccccg acatcgtgat gacccagagc cccagcagcc tgagcgccag cgtgggcgac      60

cgcgtgacca tcacctgccg cagcagcacc ggcgccgtga ccaccagcaa ctacgccagc     120

tgggtgcagg agaagcccgg caagctgttc aagggcctga tcggcggcac caacaaccgc     180

gcccccggcg tgcccagccg cttcagcggc agcctgatcg gcgacaaggc caccctgacc     240

atcagcagcc tgcagcccga ggacttcgcc acctacttct gcgccctgtg gtacagcaac     300

cactgggtgt tcggccaggg caccaaggtg gagctgaagc gcggcggcgg cggcagcggc     360

ggcggcggca gcggcggcgg cggcagcagc ggcggcggca gcgaggtgaa gctgctggag     420

agcggcggcg gcctggtgca gcccggcggc agcctgaagc tgagctgcgc cgtgagcggc     480

ttcagcctga ccgactacgg cgtgaactgg gtgcgccagg cccccggccg cggcctggag     540

tggatcggcg tgatctgggg cgacggcatc accgactaca acagcgccct gaaggaccgc     600

ttcatcatca gcaaggacaa cggcaagaac accgtgtacc tgcagatgag caaggtgcgc     660

agcgacgaca ccgccctgta ctactgcgtg accggcctgt tcgactactg gggccagggc     720

accctggtga ccgtgagcag ctacccatac gatgttccag attacgctgg tggaggcgga     780

ggttctgggg gaggaggtag tggcggtggt ggttcaggag gcggcggaag cttggatcca     840

ggtggaggtg gaagcggtag caaaggagaa gaacttttca ctggagttgt cccaattctt     900

gttgaattag atggtgatgt taatgggcac aaattttctg tccgtggaga gggtgaaggt     960

gatgctacaa acggaaaact cacccttaaa tttatttgca ctactggaaa actacctgtt    1020

ccgtggccaa cacttgtcac tactctgacc tatggtgttc aatgcttttc ccgttatccg    1080

gatcacatga aacggcatga ctttttcaag agtgccatgc ccgaaggtta tgtacaggaa    1140

cgcactatat ctttcaaaga tgacgggacc tacaagacgc gtgctgaagt caagtttgaa    1200

ggtgataccc ttgttaatcg tatcgagtta aagggtattg attttaaaga agatggaaac    1260

attcttggac acaaactcga gtacaacttt aactcacaca atgtatacat cacggcagac    1320

aaacaaaaga atggaatcaa agctaacttc aaaattcgcc acaacgttga agatggttcc    1380

gttcaactag cagaccatta tcaacaaaat actccaattg gcgatggccc tgtcctttta    1440

ccagacaacc attacctgtc gacacaatct gtcctttcga aagatcccaa cgaaaagcgt    1500

gaccacatgg tccttcttga gtttgtaact gctgctggga ttacacatgg catggatgag    1560

ctctacaaag gtggaggtcg gaccggtggc ggtggcggag gggatgcttt agacgatttt    1620

gacttagata tgcttggttc agacgcgtta gacgacttcg acctagacat gttaggctca    1680

gatgcattgg acgacttcga tttagatatg ttgggctccg atgccctaga tgactttgat    1740

ctagatatgc taggtagtgg aggaggatct cggaccgaag agtacaagct tatcctgaac    1800

ggtaaaaccc tgaaaggtga aaccaccacc gaagctgttg acgctgctac cgcggaaaaa    1860

gttttcaaac agtacgctaa cgacaacggt gttgacggtg aatggaccta cgacgacgct    1920

accaaaacct tcacggtaac cgaaggtggt ggtagcggtg gtggtactag tccaaaaaca    1980

aggaggagac cgcgaagatc acaacggaaa aggccgccta cgccatggcc gtaa          2034


<210> 56
<211> 5796
<212> DNA
<213> Artificial Sequence


<220> 
<223> dCas9m4-SV40NLS-VP64- SV40NLS-p65-Rta (VPR)

<400> 56
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtgtcg     4140

ccagggatcc gtcgacttga cgcgttgata tcaacaagtt tgtacaaaaa agcaggctac     4200

aaagaggcca gcggttccgg acgggctgac gcattggacg attttgatct ggatatgctg     4260

ggaagtgacg ccctcgatga ttttgacctt gacatgcttg gttcggatgc ccttgatgac     4320

tttgacctcg acatgctcgg cagtgacgcc cttgatgatt tcgacctgga catgctgatt     4380

aactctagaa gttccggatc tccgaaaaag aaacgcaaag ttggtagcca gtacctgccc     4440

gacaccgacg accggcaccg gatcgaggaa aagcggaagc ggacctacga gacattcaag     4500

agcatcatga agaagtcccc cttcagcggc cccaccgacc ctagacctcc acctagaaga     4560

atcgccgtgc ccagcagatc cagcgccagc gtgccaaaac ctgcccccca gccttacccc     4620

ttcaccagca gcctgagcac catcaactac gacgagttcc ctaccatggt gttccccagc     4680

ggccagatct ctcaggcctc tgctctggct ccagcccctc ctcaggtgct gcctcaggct     4740

cctgctcctg caccagctcc agccatggtg tctgcactgg ctcaggcacc agcacccgtg     4800

cctgtgctgg ctcctggacc tccacaggct gtggctccac cagcccctaa acctacacag     4860

gccggcgagg gcacactgtc tgaagctctg ctgcagctgc agttcgacga cgaggatctg     4920

ggagccctgc tgggaaacag caccgatcct gccgtgttca ccgacctggc cagcgtggac     4980

aacagcgagt tccagcagct gctgaaccag ggcatccctg tggcccctca caccaccgag     5040

cccatgctga tggaataccc cgaggccatc acccggctcg tgacaggcgc tcagaggcct     5100

cctgatccag ctcctgcccc tctgggagca ccaggcctgc ctaatggact gctgtctggc     5160

gacgaggact tcagctctat cgccgatatg gatttctcag ccttgctggg ctctggcagc     5220

ggcagccggg attccaggga agggatgttt ttgccgaagc ctgaggccgg ctccgctatt     5280

agtgacgtgt ttgagggccg cgaggtgtgc cagccaaaac gaatccggcc atttcatcct     5340

ccaggaagtc catgggccaa ccgcccactc cccgccagcc tcgcaccaac accaaccggt     5400

ccagtacatg agccagtcgg gtcactgacc ccggcaccag tccctcagcc actggatcca     5460

gcgcccgcag tgactcccga ggccagtcac ctgttggagg atcccgatga agagacgagc     5520

caggctgtca aagcccttcg ggagatggcc gatactgtga ttccccagaa ggaagaggct     5580

gcaatctgtg gccaaatgga cctttcccat ccgcccccaa ggggccatct ggatgagctg     5640

acaaccacac ttgagtccat gaccgaggat ctgaacctgg actcacccct gaccccggaa     5700

ttgaacgaga ttctggatac cttcctgaac gacgagtgcc tcttgcatgc catgcatatc     5760

agcacaggac tgtccatctt cgacacatct ctgttt                               5796


<210> 57
<211> 5796
<212> DNA
<213> Artificial Sequence


<220> 
<223> Cas9-SV40NLS-VP64-SV40NLS-p65-Rta

<400> 57
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtgtcg     4140

ccagggatcc gtcgacttga cgcgttgata tcaacaagtt tgtacaaaaa agcaggctac     4200

aaagaggcca gcggttccgg acgggctgac gcattggacg attttgatct ggatatgctg     4260

ggaagtgacg ccctcgatga ttttgacctt gacatgcttg gttcggatgc ccttgatgac     4320

tttgacctcg acatgctcgg cagtgacgcc cttgatgatt tcgacctgga catgctgatt     4380

aactctagaa gttccggatc tccgaaaaag aaacgcaaag ttggtagcca gtacctgccc     4440

gacaccgacg accggcaccg gatcgaggaa aagcggaagc ggacctacga gacattcaag     4500

agcatcatga agaagtcccc cttcagcggc cccaccgacc ctagacctcc acctagaaga     4560

atcgccgtgc ccagcagatc cagcgccagc gtgccaaaac ctgcccccca gccttacccc     4620

ttcaccagca gcctgagcac catcaactac gacgagttcc ctaccatggt gttccccagc     4680

ggccagatct ctcaggcctc tgctctggct ccagcccctc ctcaggtgct gcctcaggct     4740

cctgctcctg caccagctcc agccatggtg tctgcactgg ctcaggcacc agcacccgtg     4800

cctgtgctgg ctcctggacc tccacaggct gtggctccac cagcccctaa acctacacag     4860

gccggcgagg gcacactgtc tgaagctctg ctgcagctgc agttcgacga cgaggatctg     4920

ggagccctgc tgggaaacag caccgatcct gccgtgttca ccgacctggc cagcgtggac     4980

aacagcgagt tccagcagct gctgaaccag ggcatccctg tggcccctca caccaccgag     5040

cccatgctga tggaataccc cgaggccatc acccggctcg tgacaggcgc tcagaggcct     5100

cctgatccag ctcctgcccc tctgggagca ccaggcctgc ctaatggact gctgtctggc     5160

gacgaggact tcagctctat cgccgatatg gatttctcag ccttgctggg ctctggcagc     5220

ggcagccggg attccaggga agggatgttt ttgccgaagc ctgaggccgg ctccgctatt     5280

agtgacgtgt ttgagggccg cgaggtgtgc cagccaaaac gaatccggcc atttcatcct     5340

ccaggaagtc catgggccaa ccgcccactc cccgccagcc tcgcaccaac accaaccggt     5400

ccagtacatg agccagtcgg gtcactgacc ccggcaccag tccctcagcc actggatcca     5460

gcgcccgcag tgactcccga ggccagtcac ctgttggagg atcccgatga agagacgagc     5520

caggctgtca aagcccttcg ggagatggcc gatactgtga ttccccagaa ggaagaggct     5580

gcaatctgtg gccaaatgga cctttcccat ccgcccccaa ggggccatct ggatgagctg     5640

acaaccacac ttgagtccat gaccgaggat ctgaacctgg actcacccct gaccccggaa     5700

ttgaacgaga ttctggatac cttcctgaac gacgagtgcc tcttgcatgc catgcatatc     5760

agcacaggac tgtccatctt cgacacatct ctgttt                               5796


<210> 58
<211> 2493
<212> DNA
<213> Artificial Sequence


<220> 
<223> SV40NLS- dCas9m2-RmaIntN_coding sequence (D10A)

<400> 58
atggccccaa agaagaagcg gaaggtcggt atccacggag tcccagcagc cgacaagaag      60

tactccattg ggctcgctat cggcacaaac agcgtcggct gggccgtcat tacggacgag     120

tacaaggtgc cgagcaaaaa attcaaagtt ctgggcaata ccgatcgcca cagcataaag     180

aagaacctca ttggcgccct cctgttcgac tccggggaaa cggccgaagc cacgcggctc     240

aaaagaacag cacggcgcag atatacccgc agaaagaatc ggatctgcta cctgcaggag     300

atctttagta atgagatggc taaggtggat gactctttct tccataggct ggaggagtcc     360

tttttggtgg aggaggataa aaagcacgag cgccacccaa tctttggcaa tatcgtggac     420

gaggtggcgt accatgaaaa gtacccaacc atatatcatc tgaggaagaa gcttgtagac     480

agtactgata aggctgactt gcggttgatc tatctcgcgc tggcgcatat gatcaaattt     540

cggggacact tcctcatcga gggggacctg aacccagaca acagcgatgt cgacaaactc     600

tttatccaac tggttcagac ttacaatcag cttttcgaag agaacccgat caacgcatcc     660

ggagttgacg ccaaagcaat cctgagcgct aggctgtcca aatcccggcg gctcgaaaac     720

ctcatcgcac agctccctgg ggagaagaag aacggcctgt ttggtaatct tatcgccctg     780

tcactcgggc tgacccccaa ctttaaatct aacttcgacc tggccgaaga tgccaagctt     840

caactgagca aagacaccta cgatgatgat ctcgacaatc tgctggccca gatcggcgac     900

cagtacgcag accttttttt ggcggcaaag aacctgtcag acgccattct gctgagtgat     960

attctgcgag tgaacacgga gatcaccaaa gctccgctga gcgctagtat gatcaagcgc    1020

tatgatgagc accaccaaga cttgactttg ctgaaggccc ttgtcagaca gcaactgcct    1080

gagaagtaca aggaaatttt cttcgatcag tctaaaaatg gctacgccgg atacattgac    1140

ggcggagcaa gccaggagga attttacaaa tttattaagc ccatcttgga aaaaatggac    1200

ggcaccgagg agctgctggt aaagcttaac agagaagatc tgttgcgcaa acagcgcact    1260

ttcgacaatg gaagcatccc ccaccagatt cacctgggcg aactgcacgc tatcctcagg    1320

cggcaagagg atttctaccc ctttttgaaa gataacaggg aaaagattga gaaaatcctc    1380

acatttcgga taccctacta tgtaggcccc ctcgcccggg gaaattccag attcgcgtgg    1440

atgactcgca aatcagaaga gaccatcact ccctggaact tcgaggaagt cgtggataag    1500

ggggcctctg cccagtcctt catcgaaagg atgactaact ttgataaaaa tctgcctaac    1560

gaaaaggtgc ttcctaaaca ctctctgctg tacgagtact tcacagttta taacgagctc    1620

accaaggtca aatacgtcac agaagggatg agaaagccag cattcctgtc tggagagcag    1680

aagaaagcta tcgtggacct cctcttcaag acgaaccgga aagttaccgt gaaacagctc    1740

aaagaagact atttcaaaaa gattgaatgt ttcgactctg ttgaaatcag cggagtggag    1800

gatcgcttca acgcatccct gggaacgtat cacgatctcc tgaaaatcat taaagacaag    1860

gacttcctgg acaatgagga gaacgaggac attcttgagg acattgtcct cacccttacg    1920

ttgtttgaag atagggagat gattgaagaa cgcttgaaaa cttacgctca tctcttcgac    1980

gacaaagtca tgaaacagct caagaggcgc cgatatacag gatgggggcg gctgtcaaga    2040

aaactgatca atgggatccg agacaagcag agtggaaaga caatcctgga ttttcttaag    2100

tccgatggat ttgccaaccg gaacttcatg cagttgatcc atgatgactc tctcaccttt    2160

aaggaggaca tccagaaagc acaagtttgt ctggctggcg atactctcat taccctggcc    2220

gatggacgac gagtgcctat tagagaactg gtgtcacagc agaatttttc cgtgtgggct    2280

ctgaatcctc agacttaccg cctggagagg gctagagtga gtagagcttt ctgtaccggc    2340

atcaaacctg tgtaccgcct caccactaga ctggggagat ccattagggc cactgccaac    2400

caccgatttc tcacacctca gggctggaaa cgagtcgatg aactccagcc tggagattac    2460

ctggctctgc ctaggagaat ccctactgcc tcc                                 2493


<210> 59
<211> 3813
<212> DNA
<213> Artificial Sequence


<220> 
<223> RmaIntC-dCas9m2-VP64-p65-Rta (D839A: GAT>GCT, H840A, N863A:
      AAT>GCT)

<400> 59
atggcggcgg cgtgcccgga actgcgtcag ctggcgcaga gcgatgtgta ttgggatccg       60

attgtgagca ttgaaccgga tggcgtggaa gaagtgtttg atctgaccgt gccgggcccg      120

cataactttg tggcgaacga tattattgcg cataactctg gccaggggga cagtcttcac      180

gagcacatcg ctaatcttgc aggtagccca gctatcaaaa agggaatact gcagaccgtt      240

aaggtcgtgg atgaactcgt caaagtaatg ggaaggcata agcccgagaa tatcgttatc      300

gagatggccc gagagaacca aactacccag aagggacaga agaacagtag ggaaaggatg      360

aagaggattg aagagggtat aaaagaactg gggtcccaaa tccttaagga acacccagtt      420

gaaaacaccc agcttcagaa tgagaagctc tacctgtact acctgcagaa cggcagggac      480

atgtacgtgg atcaggaact ggacatcaat cggctctccg actacgacgt ggatgctatc      540

gtgccccagt cttttctcaa agatgattct attgataata aagtgttgac aagatccgat      600

aaaaatagag ggaagagtga taacgtcccc tcagaagaag ttgtcaagaa aatgaaaaat      660

tattggcggc agctgctgaa cgccaaactg atcacacaac ggaagttcga taatctgact      720

aaggctgaac gaggtggcct gtctgagttg gataaagccg gcttcatcaa aaggcagctt      780

gttgagacac gccagatcac caagcacgtg gcccaaattc tcgattcacg catgaacacc      840

aagtacgatg aaaatgacaa actgattcga gaggtgaaag ttattactct gaagtctaag      900

ctggtctcag atttcagaaa ggactttcag ttttataagg tgagagagat caacaattac      960

caccatgcgc atgatgccta cctgaatgca gtggtaggca ctgcacttat caaaaaatat     1020

cccaagcttg aatctgaatt tgtttacgga gactataaag tgtacgatgt taggaaaatg     1080

atcgcaaagt ctgagcagga aataggcaag gccaccgcta agtacttctt ttacagcaat     1140

attatgaatt ttttcaagac cgagattaca ctggccaatg gagagattcg gaagcgacca     1200

cttatcgaaa caaacggaga aacaggagaa atcgtgtggg acaagggtag ggatttcgcg     1260

acagtccgga aggtcctgtc catgccgcag gtgaacatcg ttaaaaagac cgaagtacag     1320

accggaggct tctccaagga aagtatcctc ccgaaaagga acagcgacaa gctgatcgca     1380

cgcaaaaaag attgggaccc caagaaatac ggcggattcg attctcctac agtcgcttac     1440

agtgtactgg ttgtggccaa agtggagaaa gggaagtcta aaaaactcaa aagcgtcaag     1500

gaactgctgg gcatcacaat catggagcga tcaagcttcg aaaaaaaccc catcgacttt     1560

ctcgaggcga aaggatataa agaggtcaaa aaagacctca tcattaagct tcccaagtac     1620

tctctctttg agcttgaaaa cggccggaaa cgaatgctcg ctagtgcggg cgagctgcag     1680

aaaggtaacg agctggcact gccctctaaa tacgttaatt tcttgtatct ggccagccac     1740

tatgaaaagc tcaaagggtc tcccgaagat aatgagcaga agcagctgtt cgtggaacaa     1800

cacaaacact accttgatga gatcatcgag caaataagcg aattctccaa aagagtgatc     1860

ctcgccgacg ctaacctcga taaggtgctt tctgcttaca ataagcacag ggataagccc     1920

atcagggagc aggcagaaaa cattatccac ttgtttactc tgaccaactt gggcgcgcct     1980

gcagccttca agtacttcga caccaccata gacagaaagc ggtacacctc tacaaaggag     2040

gtcctggacg ccacactgat tcatcagtca attacggggc tctatgaaac aagaatcgac     2100

ctctctcagc tcggtggaga cagcagggct gaccccaaga agaagaggaa ggtgtcgcca     2160

gggatccgtc gacttgacgc gttgatatca acaagtttgt acaaaaaagc aggctacaaa     2220

gaggccagcg gttccggacg ggctgacgca ttggacgatt ttgatctgga tatgctggga     2280

agtgacgccc tcgatgattt tgaccttgac atgcttggtt cggatgccct tgatgacttt     2340

gacctcgaca tgctcggcag tgacgccctt gatgatttcg acctggacat gctgattaac     2400

tctagaagtt ccggatctcc gaaaaagaaa cgcaaagttg gtagccagta cctgcccgac     2460

accgacgacc ggcaccggat cgaggaaaag cggaagcgga cctacgagac attcaagagc     2520

atcatgaaga agtccccctt cagcggcccc accgacccta gacctccacc tagaagaatc     2580

gccgtgccca gcagatccag cgccagcgtg ccaaaacctg ccccccagcc ttaccccttc     2640

accagcagcc tgagcaccat caactacgac gagttcccta ccatggtgtt ccccagcggc     2700

cagatctctc aggcctctgc tctggctcca gcccctcctc aggtgctgcc tcaggctcct     2760

gctcctgcac cagctccagc catggtgtct gcactggctc aggcaccagc acccgtgcct     2820

gtgctggctc ctggacctcc acaggctgtg gctccaccag cccctaaacc tacacaggcc     2880

ggcgagggca cactgtctga agctctgctg cagctgcagt tcgacgacga ggatctggga     2940

gccctgctgg gaaacagcac cgatcctgcc gtgttcaccg acctggccag cgtggacaac     3000

agcgagttcc agcagctgct gaaccagggc atccctgtgg cccctcacac caccgagccc     3060

atgctgatgg aataccccga ggccatcacc cggctcgtga caggcgctca gaggcctcct     3120

gatccagctc ctgcccctct gggagcacca ggcctgccta atggactgct gtctggcgac     3180

gaggacttca gctctatcgc cgatatggat ttctcagcct tgctgggctc tggcagcggc     3240

agccgggatt ccagggaagg gatgtttttg ccgaagcctg aggccggctc cgctattagt     3300

gacgtgtttg agggccgcga ggtgtgccag ccaaaacgaa tccggccatt tcatcctcca     3360

ggaagtccat gggccaaccg cccactcccc gccagcctcg caccaacacc aaccggtcca     3420

gtacatgagc cagtcgggtc actgaccccg gcaccagtcc ctcagccact ggatccagcg     3480

cccgcagtga ctcccgaggc cagtcacctg ttggaggatc ccgatgaaga gacgagccag     3540

gctgtcaaag cccttcggga gatggccgat actgtgattc cccagaagga agaggctgca     3600

atctgtggcc aaatggacct ttcccatccg cccccaaggg gccatctgga tgagctgaca     3660

accacacttg agtccatgac cgaggatctg aacctggact cacccctgac cccggaattg     3720

aacgagattc tggatacctt cctgaacgac gagtgcctct tgcatgccat gcatatcagc     3780

acaggactgt ccatcttcga cacatctctg ttt                                  3813


<210> 60
<211> 4532
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hRHO-RmaIntC-dCas9C(m2)-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 60
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagccc tctcctccct      240

gacctcaggc ttcctcctag tgtcaccttg gcccctctta gaagccaatt aggccctcag      300

tttctgcagc ggggattaat atgattatga acacccccaa tctcccagat gctgattcag      360

ccaggagctt aggaggggga ggtcacttta taagggtctg ggggggtcag aacccagagt      420

catcggtacc accggtcgac tagaggatcc atggcggcgg cgtgcccgga actgcgtcag      480

ctggcgcaga gcgatgtgta ttgggatccg attgtgagca ttgaaccgga tggcgtggaa      540

gaagtgtttg atctgaccgt gccgggcccg cataactttg tggcgaacga tattattgcg      600

cataactctg gccaggggga cagtcttcac gagcacatcg ctaatcttgc aggtagccca      660

gctatcaaaa agggaatact gcagaccgtt aaggtcgtgg atgaactcgt caaagtaatg      720

ggaaggcata agcccgagaa tatcgttatc gagatggccc gagagaacca aactacccag      780

aagggacaga agaacagtag ggaaaggatg aagaggattg aagagggtat aaaagaactg      840

gggtcccaaa tccttaagga acacccagtt gaaaacaccc agcttcagaa tgagaagctc      900

tacctgtact acctgcagaa cggcagggac atgtacgtgg atcaggaact ggacatcaat      960

cggctctccg actacgacgt ggatgctatc gtgccccagt cttttctcaa agatgattct     1020

attgataata aagtgttgac aagatccgat aaaaatagag ggaagagtga taacgtcccc     1080

tcagaagaag ttgtcaagaa aatgaaaaat tattggcggc agctgctgaa cgccaaactg     1140

atcacacaac ggaagttcga taatctgact aaggctgaac gaggtggcct gtctgagttg     1200

gataaagccg gcttcatcaa aaggcagctt gttgagacac gccagatcac caagcacgtg     1260

gcccaaattc tcgattcacg catgaacacc aagtacgatg aaaatgacaa actgattcga     1320

gaggtgaaag ttattactct gaagtctaag ctggtctcag atttcagaaa ggactttcag     1380

ttttataagg tgagagagat caacaattac caccatgcgc atgatgccta cctgaatgca     1440

gtggtaggca ctgcacttat caaaaaatat cccaagcttg aatctgaatt tgtttacgga     1500

gactataaag tgtacgatgt taggaaaatg atcgcaaagt ctgagcagga aataggcaag     1560

gccaccgcta agtacttctt ttacagcaat attatgaatt ttttcaagac cgagattaca     1620

ctggccaatg gagagattcg gaagcgacca cttatcgaaa caaacggaga aacaggagaa     1680

atcgtgtggg acaagggtag ggatttcgcg acagtccgga aggtcctgtc catgccgcag     1740

gtgaacatcg ttaaaaagac cgaagtacag accggaggct tctccaagga aagtatcctc     1800

ccgaaaagga acagcgacaa gctgatcgca cgcaaaaaag attgggaccc caagaaatac     1860

ggcggattcg attctcctac agtcgcttac agtgtactgg ttgtggccaa agtggagaaa     1920

gggaagtcta aaaaactcaa aagcgtcaag gaactgctgg gcatcacaat catggagcga     1980

tcaagcttcg aaaaaaaccc catcgacttt ctcgaggcga aaggatataa agaggtcaaa     2040

aaagacctca tcattaagct tcccaagtac tctctctttg agcttgaaaa cggccggaaa     2100

cgaatgctcg ctagtgcggg cgagctgcag aaaggtaacg agctggcact gccctctaaa     2160

tacgttaatt tcttgtatct ggccagccac tatgaaaagc tcaaagggtc tcccgaagat     2220

aatgagcaga agcagctgtt cgtggaacaa cacaaacact accttgatga gatcatcgag     2280

caaataagcg aattctccaa aagagtgatc ctcgccgacg ctaacctcga taaggtgctt     2340

tctgcttaca ataagcacag ggataagccc atcagggagc aggcagaaaa cattatccac     2400

ttgtttactc tgaccaactt gggcgcgcct gcagccttca agtacttcga caccaccata     2460

gacagaaagc ggtacacctc tacaaaggag gtcctggacg ccacactgat tcatcagtca     2520

attacggggc tctatgaaac aagaatcgac ctctctcagc tcggtggaga cagcagggct     2580

gaccccaaga agaagaggaa ggtgtcgcca gggatccgtc gacttgacgc gttgatatca     2640

acaagtttgt acaaaaaagc aggctacaaa gaggccagcg gttccggacg ggctgacgca     2700

ttggacgatt ttgatctgga tatgctggga agtgacgccc tcgatgattt tgaccttgac     2760

atgcttggtt cggatgccct tgatgacttt gacctcgaca tgctcggcag tgacgccctt     2820

gatgatttcg acctggacat gctgattaac tctagaagtt ccggatctcc gaaaaagaaa     2880

cgcaaagttg gtagccagta cctgcccgac accgacgacc ggcaccggat cgaggaaaag     2940

cggaagcgga cctacgagac attcaagagc atcatgaaga agtccccctt cagcggcccc     3000

accgacccta gacctccacc tagaagaatc gccgtgccca gcagatccag cgccagcgtg     3060

ccaaaacctg ccccccagcc ttaccccttc accagcagcc tgagcaccat caactacgac     3120

gagttcccta ccatggtgtt ccccagcggc cagatctctc aggcctctgc tctggctcca     3180

gcccctcctc aggtgctgcc tcaggctcct gctcctgcac cagctccagc catggtgtct     3240

gcactggctc aggcaccagc acccgtgcct gtgctggctc ctggacctcc acaggctgtg     3300

gctccaccag cccctaaacc tacacaggcc ggcgagggca cactgtctga agctctgctg     3360

cagctgcagt tcgacgacga ggatctggga gccctgctgg gaaacagcac cgatcctgcc     3420

gtgttcaccg acctggccag cgtggacaac agcgagttcc agcagctgct gaaccagggc     3480

atccctgtgg cccctcacac caccgagccc atgctgatgg aataccccga ggccatcacc     3540

cggctcgtga caggcgctca gaggcctcct gatccagctc ctgcccctct gggagcacca     3600

ggcctgccta atggactgct gtctggcgac gaggacttca gctctatcgc cgatatggat     3660

ttctcagcct tgctgggctc tggcagcggc agccgggatt ccagggaagg gatgtttttg     3720

ccgaagcctg aggccggctc cgctattagt gacgtgtttg agggccgcga ggtgtgccag     3780

ccaaaacgaa tccggccatt tcatcctcca ggaagtccat gggccaaccg cccactcccc     3840

gccagcctcg caccaacacc aaccggtcca gtacatgagc cagtcgggtc actgaccccg     3900

gcaccagtcc ctcagccact ggatccagcg cccgcagtga ctcccgaggc cagtcacctg     3960

ttggaggatc ccgatgaaga gacgagccag gctgtcaaag cccttcggga gatggccgat     4020

actgtgattc cccagaagga agaggctgca atctgtggcc aaatggacct ttcccatccg     4080

cccccaaggg gccatctgga tgagctgaca accacacttg agtccatgac cgaggatctg     4140

aacctggact cacccctgac cccggaattg aacgagattc tggatacctt cctgaacgac     4200

gagtgcctct tgcatgccat gcatatcagc acaggactgt ccatcttcga cacatctctg     4260

ttttgacaat aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtctcga     4320

gttaagggcg aattcccgat taggatcttc ctagagcatg gctacgtaga taagtagcat     4380

ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg     4440

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4500

cgggcggcct cagtgagcga gcgagcgcgc ag                                   4532


<210> 61
<211> 4848
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-mSWS-RmaIntC-dCas9C(m2)-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 61
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcag gatgcagttg      240

tttctgcact gtcccgcagt ggctatttaa aatgctccca agggggcctc cccactcatc      300

ctcttcctgt ttccccaagc ggattcccag gtctctggat agggacactc aggtgagcat      360

ctttcacaaa gggccaggtg agatgcagag gagcctgaag ccaaaggcag aggtgggaat      420

gaggtatggc agcatctcca aagaatatag gtcagcatcc tccaggccac agaaaccaat      480

actgacccca aagcacccag ccttgttatc caggtttctg acctcaatct cttatcctct      540

gaagaacaca atcaatcagc tttgggctca tgaaaggttt aggtgagaac taagagatct      600

ctaatctggg actttgtctt tgggaggctt aggatagttc agagtctcaa ctgtatcttt      660

aaaggagggt gctgtaggga agggtgatag cagaagaatc gtctataaga gggaccggag      720

gtggtagtga gggcatccca agcgggaccg gtcgactaga ggatccatgg cggcggcgtg      780

cccggaactg cgtcagctgg cgcagagcga tgtgtattgg gatccgattg tgagcattga      840

accggatggc gtggaagaag tgtttgatct gaccgtgccg ggcccgcata actttgtggc      900

gaacgatatt attgcgcata actctggcca gggggacagt cttcacgagc acatcgctaa      960

tcttgcaggt agcccagcta tcaaaaaggg aatactgcag accgttaagg tcgtggatga     1020

actcgtcaaa gtaatgggaa ggcataagcc cgagaatatc gttatcgaga tggcccgaga     1080

gaaccaaact acccagaagg gacagaagaa cagtagggaa aggatgaaga ggattgaaga     1140

gggtataaaa gaactggggt cccaaatcct taaggaacac ccagttgaaa acacccagct     1200

tcagaatgag aagctctacc tgtactacct gcagaacggc agggacatgt acgtggatca     1260

ggaactggac atcaatcggc tctccgacta cgacgtggat gctatcgtgc cccagtcttt     1320

tctcaaagat gattctattg ataataaagt gttgacaaga tccgataaaa atagagggaa     1380

gagtgataac gtcccctcag aagaagttgt caagaaaatg aaaaattatt ggcggcagct     1440

gctgaacgcc aaactgatca cacaacggaa gttcgataat ctgactaagg ctgaacgagg     1500

tggcctgtct gagttggata aagccggctt catcaaaagg cagcttgttg agacacgcca     1560

gatcaccaag cacgtggccc aaattctcga ttcacgcatg aacaccaagt acgatgaaaa     1620

tgacaaactg attcgagagg tgaaagttat tactctgaag tctaagctgg tctcagattt     1680

cagaaaggac tttcagtttt ataaggtgag agagatcaac aattaccacc atgcgcatga     1740

tgcctacctg aatgcagtgg taggcactgc acttatcaaa aaatatccca agcttgaatc     1800

tgaatttgtt tacggagact ataaagtgta cgatgttagg aaaatgatcg caaagtctga     1860

gcaggaaata ggcaaggcca ccgctaagta cttcttttac agcaatatta tgaatttttt     1920

caagaccgag attacactgg ccaatggaga gattcggaag cgaccactta tcgaaacaaa     1980

cggagaaaca ggagaaatcg tgtgggacaa gggtagggat ttcgcgacag tccggaaggt     2040

cctgtccatg ccgcaggtga acatcgttaa aaagaccgaa gtacagaccg gaggcttctc     2100

caaggaaagt atcctcccga aaaggaacag cgacaagctg atcgcacgca aaaaagattg     2160

ggaccccaag aaatacggcg gattcgattc tcctacagtc gcttacagtg tactggttgt     2220

ggccaaagtg gagaaaggga agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat     2280

cacaatcatg gagcgatcaa gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg     2340

atataaagag gtcaaaaaag acctcatcat taagcttccc aagtactctc tctttgagct     2400

tgaaaacggc cggaaacgaa tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct     2460

ggcactgccc tctaaatacg ttaatttctt gtatctggcc agccactatg aaaagctcaa     2520

agggtctccc gaagataatg agcagaagca gctgttcgtg gaacaacaca aacactacct     2580

tgatgagatc atcgagcaaa taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa     2640

cctcgataag gtgctttctg cttacaataa gcacagggat aagcccatca gggagcaggc     2700

agaaaacatt atccacttgt ttactctgac caacttgggc gcgcctgcag ccttcaagta     2760

cttcgacacc accatagaca gaaagcggta cacctctaca aaggaggtcc tggacgccac     2820

actgattcat cagtcaatta cggggctcta tgaaacaaga atcgacctct ctcagctcgg     2880

tggagacagc agggctgacc ccaagaagaa gaggaaggtg tcgccaggga tccgtcgact     2940

tgacgcgttg atatcaacaa gtttgtacaa aaaagcaggc tacaaagagg ccagcggttc     3000

cggacgggct gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga     3060

tgattttgac cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct     3120

cggcagtgac gcccttgatg atttcgacct ggacatgctg attaactcta gaagttccgg     3180

atctccgaaa aagaaacgca aagttggtag ccagtacctg cccgacaccg acgaccggca     3240

ccggatcgag gaaaagcgga agcggaccta cgagacattc aagagcatca tgaagaagtc     3300

ccccttcagc ggccccaccg accctagacc tccacctaga agaatcgccg tgcccagcag     3360

atccagcgcc agcgtgccaa aacctgcccc ccagccttac cccttcacca gcagcctgag     3420

caccatcaac tacgacgagt tccctaccat ggtgttcccc agcggccaga tctctcaggc     3480

ctctgctctg gctccagccc ctcctcaggt gctgcctcag gctcctgctc ctgcaccagc     3540

tccagccatg gtgtctgcac tggctcaggc accagcaccc gtgcctgtgc tggctcctgg     3600

acctccacag gctgtggctc caccagcccc taaacctaca caggccggcg agggcacact     3660

gtctgaagct ctgctgcagc tgcagttcga cgacgaggat ctgggagccc tgctgggaaa     3720

cagcaccgat cctgccgtgt tcaccgacct ggccagcgtg gacaacagcg agttccagca     3780

gctgctgaac cagggcatcc ctgtggcccc tcacaccacc gagcccatgc tgatggaata     3840

ccccgaggcc atcacccggc tcgtgacagg cgctcagagg cctcctgatc cagctcctgc     3900

ccctctggga gcaccaggcc tgcctaatgg actgctgtct ggcgacgagg acttcagctc     3960

tatcgccgat atggatttct cagccttgct gggctctggc agcggcagcc gggattccag     4020

ggaagggatg tttttgccga agcctgaggc cggctccgct attagtgacg tgtttgaggg     4080

ccgcgaggtg tgccagccaa aacgaatccg gccatttcat cctccaggaa gtccatgggc     4140

caaccgccca ctccccgcca gcctcgcacc aacaccaacc ggtccagtac atgagccagt     4200

cgggtcactg accccggcac cagtccctca gccactggat ccagcgcccg cagtgactcc     4260

cgaggccagt cacctgttgg aggatcccga tgaagagacg agccaggctg tcaaagccct     4320

tcgggagatg gccgatactg tgattcccca gaaggaagag gctgcaatct gtggccaaat     4380

ggacctttcc catccgcccc caaggggcca tctggatgag ctgacaacca cacttgagtc     4440

catgaccgag gatctgaacc tggactcacc cctgaccccg gaattgaacg agattctgga     4500

taccttcctg aacgacgagt gcctcttgca tgccatgcat atcagcacag gactgtccat     4560

cttcgacaca tctctgtttt gacaataaaa tatctttatt ttcattacat ctgtgtgttg     4620

gttttttgtg tctcgagtta agggcgaatt cccgattagg atcttcctag agcatggcta     4680

cgtagataag tagcatggcg ggttaatcat taactacaag gaacccctag tgatggagtt     4740

ggccactccc tctctgcgcg ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg     4800

acgcccgggc tttgcccggg cggcctcagt gagcgagcga gcgcgcag                  4848


<210> 62
<211> 4679
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Cnga1.sgRNA#1-sgRNAscaffold-hU6-Cnga1.sgRNA#2-sgRNAscaffo
      ld-hU6-Cnga1.sgRNA#3-sgRNAscaffold-mSWS-NLS-dCas9N(m2)-RmaIntN-pA
      -ITR

<400> 62
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtaggcgacc      480

ggctttgaga agttttagag ctagaaatag caagttaaaa taaggctagt ccgttatcaa      540

cttgaaaaag tggcaccgag tcggtgcttt ttttgtatac gagggcctat ttcccatgat      600

tccttcatat ttgcatatac gatacaaggc tgttagagag ataattggaa ttaatttgac      660

tgtaaacaca aagatattag tacaaaatac gtgacgtaga aagtaataat ttcttgggta      720

gtttgcagtt ttaaaattat gttttaaaat ggactatcat atgcttaccg taacttgaaa      780

gtatttcgat ttcttggctt tatatatctt gtggaaagga cgaaacaccg ctgtggaagt      840

ctccaaacgc gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      900

ttgaaaaagt ggcaccgagt cggtgctttt tttgttaacg agggcctatt tcccatgatt      960

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact     1020

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag     1080

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag     1140

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgt cttctctctc     1200

ggcgctatgg ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact     1260

tgaaaaagtg gcaccgagtc ggtgcttttt ttatttaaat agctagcagg atgcagttgt     1320

ttctgcactg tcccgcagtg gctatttaaa atgctcccaa gggggcctcc ccactcatcc     1380

tcttcctgtt tccccaagcg gattcccagg tctctggata gggacactca ggtgagcatc     1440

tttcacaaag ggccaggtga gatgcagagg agcctgaagc caaaggcaga ggtgggaatg     1500

aggtatggca gcatctccaa agaatatagg tcagcatcct ccaggccaca gaaaccaata     1560

ctgaccccaa agcacccagc cttgttatcc aggtttctga cctcaatctc ttatcctctg     1620

aagaacacaa tcaatcagct ttgggctcat gaaaggttta ggtgagaact aagagatctc     1680

taatctggga ctttgtcttt gggaggctta ggatagttca gagtctcaac tgtatcttta     1740

aaggagggtg ctgtagggaa gggtgatagc agaagaatcg tctataagag ggaccggagg     1800

tggtagtgag ggcatcccaa gcgggaccgg tcgactagag gatccatggc cccaaagaag     1860

aagcggaagg tcggtatcca cggagtccca gcagccgaca agaagtactc cattgggctc     1920

gctatcggca caaacagcgt cggctgggcc gtcattacgg acgagtacaa ggtgccgagc     1980

aaaaaattca aagttctggg caataccgat cgccacagca taaagaagaa cctcattggc     2040

gccctcctgt tcgactccgg ggaaacggcc gaagccacgc ggctcaaaag aacagcacgg     2100

cgcagatata cccgcagaaa gaatcggatc tgctacctgc aggagatctt tagtaatgag     2160

atggctaagg tggatgactc tttcttccat aggctggagg agtccttttt ggtggaggag     2220

gataaaaagc acgagcgcca cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat     2280

gaaaagtacc caaccatata tcatctgagg aagaagcttg tagacagtac tgataaggct     2340

gacttgcggt tgatctatct cgcgctggcg catatgatca aatttcgggg acacttcctc     2400

atcgaggggg acctgaaccc agacaacagc gatgtcgaca aactctttat ccaactggtt     2460

cagacttaca atcagctttt cgaagagaac ccgatcaacg catccggagt tgacgccaaa     2520

gcaatcctga gcgctaggct gtccaaatcc cggcggctcg aaaacctcat cgcacagctc     2580

cctggggaga agaagaacgg cctgtttggt aatcttatcg ccctgtcact cgggctgacc     2640

cccaacttta aatctaactt cgacctggcc gaagatgcca agcttcaact gagcaaagac     2700

acctacgatg atgatctcga caatctgctg gcccagatcg gcgaccagta cgcagacctt     2760

tttttggcgg caaagaacct gtcagacgcc attctgctga gtgatattct gcgagtgaac     2820

acggagatca ccaaagctcc gctgagcgct agtatgatca agcgctatga tgagcaccac     2880

caagacttga ctttgctgaa ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa     2940

attttcttcg atcagtctaa aaatggctac gccggataca ttgacggcgg agcaagccag     3000

gaggaatttt acaaatttat taagcccatc ttggaaaaaa tggacggcac cgaggagctg     3060

ctggtaaagc ttaacagaga agatctgttg cgcaaacagc gcactttcga caatggaagc     3120

atcccccacc agattcacct gggcgaactg cacgctatcc tcaggcggca agaggatttc     3180

tacccctttt tgaaagataa cagggaaaag attgagaaaa tcctcacatt tcggataccc     3240

tactatgtag gccccctcgc ccggggaaat tccagattcg cgtggatgac tcgcaaatca     3300

gaagagacca tcactccctg gaacttcgag gaagtcgtgg ataagggggc ctctgcccag     3360

tccttcatcg aaaggatgac taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct     3420

aaacactctc tgctgtacga gtacttcaca gtttataacg agctcaccaa ggtcaaatac     3480

gtcacagaag ggatgagaaa gccagcattc ctgtctggag agcagaagaa agctatcgtg     3540

gacctcctct tcaagacgaa ccggaaagtt accgtgaaac agctcaaaga agactatttc     3600

aaaaagattg aatgtttcga ctctgttgaa atcagcggag tggaggatcg cttcaacgca     3660

tccctgggaa cgtatcacga tctcctgaaa atcattaaag acaaggactt cctggacaat     3720

gaggagaacg aggacattct tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg     3780

gagatgattg aagaacgctt gaaaacttac gctcatctct tcgacgacaa agtcatgaaa     3840

cagctcaaga ggcgccgata tacaggatgg gggcggctgt caagaaaact gatcaatggg     3900

atccgagaca agcagagtgg aaagacaatc ctggattttc ttaagtccga tggatttgcc     3960

aaccggaact tcatgcagtt gatccatgat gactctctca cctttaagga ggacatccag     4020

aaagcacaag tttgtctggc tggcgatact ctcattaccc tggccgatgg acgacgagtg     4080

cctattagag aactggtgtc acagcagaat ttttccgtgt gggctctgaa tcctcagact     4140

taccgcctgg agagggctag agtgagtaga gctttctgta ccggcatcaa acctgtgtac     4200

cgcctcacca ctagactggg gagatccatt agggccactg ccaaccaccg atttctcaca     4260

cctcagggct ggaaacgagt cgatgaactc cagcctggag attacctggc tctgcctagg     4320

agaatcccta ctgcctcctg atctcgagct cgatgagttt ggacaaacca caactagaat     4380

gcagtgaaaa aaatgcttta tttgtgaaat ttgtgatgct attgctttat ttgtaaccat     4440

tataagctgc aataaacaag ttctcgagtt aagggcgaat tcccgattag gatcttccta     4500

gagcatggct acgtagataa gtagcatggc gggttaatca ttaactacaa ggaaccccta     4560

gtgatggagt tggccactcc ctctctgcgc gctcgctcgc tcactgaggc cgggcgacca     4620

aaggtcgccc gacgcccggg ctttgcccgg gcggcctcag tgagcgagcg agcgcgcag      4679


<210> 63
<211> 4356
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Opn1mw.sgRNA#1-sgRNAscaffold-hU6-Opn1mw.sgRNA#2-sgRNAscaf
      fold-hU6-Opn1mw.sgRNA#3-sgRNAscaffold-hRHO-NLS-dCas9N(m2)-RmaIntN
      -pA-ITR

<400> 63
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtttgggggc      480

ctttaaggta gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgc ctgagccacc      840

cctgtggatg ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact      900

tgaaaaagtg gcaccgagtc ggtgcttttt ttgttaacga gggcctattt cccatgattc      960

cttcatattt gcatatacga tacaaggctg ttagagagat aattggaatt aatttgactg     1020

taaacacaaa gatattagta caaaatacgt gacgtagaaa gtaataattt cttgggtagt     1080

ttgcagtttt aaaattatgt tttaaaatgg actatcatat gcttaccgta acttgaaagt     1140

atttcgattt cttggcttta tatatcttgt ggaaaggacg aaacaccgta gctcttgctt     1200

gtttacaagt tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt     1260

gaaaaagtgg caccgagtcg gtgctttttt tatttaaata gctagccctc tcctccctga     1320

cctcaggctt cctcctagtg tcaccttggc ccctcttaga agccaattag gccctcagtt     1380

tctgcagcgg ggattaatat gattatgaac acccccaatc tcccagatgc tgattcagcc     1440

aggagcttag gagggggagg tcactttata agggtctggg ggggtcagaa cccagagtca     1500

tcaccggtcg actagaggat ccatggcccc aaagaagaag cggaaggtcg gtatccacgg     1560

agtcccagca gccgacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg     1620

ctgggccgtc attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa     1680

taccgatcgc cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga     1740

aacggccgaa gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa     1800

tcggatctgc tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt     1860

cttccatagg ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc     1920

aatctttggc aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca     1980

tctgaggaag aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc     2040

gctggcgcat atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga     2100

caacagcgat gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga     2160

agagaacccg atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc     2220

caaatcccgg cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct     2280

gtttggtaat cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga     2340

cctggccgaa gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa     2400

tctgctggcc cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc     2460

agacgccatt ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct     2520

gagcgctagt atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc     2580

ccttgtcaga cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa     2640

tggctacgcc ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa     2700

gcccatcttg gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga     2760

tctgttgcgc aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg     2820

cgaactgcac gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag     2880

ggaaaagatt gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg     2940

gggaaattcc agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa     3000

cttcgaggaa gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa     3060

ctttgataaa aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta     3120

cttcacagtt tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc     3180

agcattcctg tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg     3240

gaaagttacc gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc     3300

tgttgaaatc agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct     3360

cctgaaaatc attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga     3420

ggacattgtc ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa     3480

aacttacgct catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac     3540

aggatggggg cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa     3600

gacaatcctg gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat     3660

ccatgatgac tctctcacct ttaaggagga catccagaaa gcacaagttt gtctggctgg     3720

cgatactctc attaccctgg ccgatggacg acgagtgcct attagagaac tggtgtcaca     3780

gcagaatttt tccgtgtggg ctctgaatcc tcagacttac cgcctggaga gggctagagt     3840

gagtagagct ttctgtaccg gcatcaaacc tgtgtaccgc ctcaccacta gactggggag     3900

atccattagg gccactgcca accaccgatt tctcacacct cagggctgga aacgagtcga     3960

tgaactccag cctggagatt acctggctct gcctaggaga atccctactg cctcctgatc     4020

tcgagctcga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt     4080

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagttc     4140

tcgagttaag ggcgaattcc cgattaggat cttcctagag catggctacg tagataagta     4200

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4260

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4320

tgcccgggcg gcctcagtga gcgagcgagc gcgcag                               4356


<210> 64
<211> 4356
<212> DNA
<213> Artificial Sequence


<220> 
<223> pAAV-3xsgRNA.Opn1sw-hRHO_dCas9N-IntN-SV40polyA
      ITR-hU6-Opn1sw.sgRNA#1-sgRNAscaffold-hU6-Opn1sw.sgRNA#2-sgRNAscaf
      fold-hU6-Opn1sw.sgRNA#3-sgRNAscaffold-hRHO-NLS-dCas9N(m2)-RmaIntN
      -SV40pA-ITR

<400> 64
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gaacacaatc      480

aatcagcttt gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccga gcacccagcc      840

ttgttatccg ttttagagct agaaatagca agttaaaata aggctagtcc gttatcaact      900

tgaaaaagtg gcaccgagtc ggtgcttttt ttgttaacga gggcctattt cccatgattc      960

cttcatattt gcatatacga tacaaggctg ttagagagat aattggaatt aatttgactg     1020

taaacacaaa gatattagta caaaatacgt gacgtagaaa gtaataattt cttgggtagt     1080

ttgcagtttt aaaattatgt tttaaaatgg actatcatat gcttaccgta acttgaaagt     1140

atttcgattt cttggcttta tatatcttgt ggaaaggacg aaacaccgag catctttcac     1200

aaagggccgt tttagagcta gaaatagcaa gttaaaataa ggctagtccg ttatcaactt     1260

gaaaaagtgg caccgagtcg gtgctttttt tatttaaata gctagccctc tcctccctga     1320

cctcaggctt cctcctagtg tcaccttggc ccctcttaga agccaattag gccctcagtt     1380

tctgcagcgg ggattaatat gattatgaac acccccaatc tcccagatgc tgattcagcc     1440

aggagcttag gagggggagg tcactttata agggtctggg ggggtcagaa cccagagtca     1500

tcaccggtcg actagaggat ccatggcccc aaagaagaag cggaaggtcg gtatccacgg     1560

agtcccagca gccgacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg     1620

ctgggccgtc attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa     1680

taccgatcgc cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga     1740

aacggccgaa gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa     1800

tcggatctgc tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt     1860

cttccatagg ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc     1920

aatctttggc aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca     1980

tctgaggaag aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc     2040

gctggcgcat atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga     2100

caacagcgat gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga     2160

agagaacccg atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc     2220

caaatcccgg cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct     2280

gtttggtaat cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga     2340

cctggccgaa gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa     2400

tctgctggcc cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc     2460

agacgccatt ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct     2520

gagcgctagt atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc     2580

ccttgtcaga cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa     2640

tggctacgcc ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa     2700

gcccatcttg gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga     2760

tctgttgcgc aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg     2820

cgaactgcac gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag     2880

ggaaaagatt gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg     2940

gggaaattcc agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa     3000

cttcgaggaa gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa     3060

ctttgataaa aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta     3120

cttcacagtt tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc     3180

agcattcctg tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg     3240

gaaagttacc gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc     3300

tgttgaaatc agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct     3360

cctgaaaatc attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga     3420

ggacattgtc ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa     3480

aacttacgct catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac     3540

aggatggggg cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa     3600

gacaatcctg gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat     3660

ccatgatgac tctctcacct ttaaggagga catccagaaa gcacaagttt gtctggctgg     3720

cgatactctc attaccctgg ccgatggacg acgagtgcct attagagaac tggtgtcaca     3780

gcagaatttt tccgtgtggg ctctgaatcc tcagacttac cgcctggaga gggctagagt     3840

gagtagagct ttctgtaccg gcatcaaacc tgtgtaccgc ctcaccacta gactggggag     3900

atccattagg gccactgcca accaccgatt tctcacacct cagggctgga aacgagtcga     3960

tgaactccag cctggagatt acctggctct gcctaggaga atccctactg cctcctgatc     4020

tcgagctcga tgagtttgga caaaccacaa ctagaatgca gtgaaaaaaa tgctttattt     4080

gtgaaatttg tgatgctatt gctttatttg taaccattat aagctgcaat aaacaagttc     4140

tcgagttaag ggcgaattcc cgattaggat cttcctagag catggctacg tagataagta     4200

gcatggcggg ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc     4260

tctgcgcgct cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt     4320

tgcccgggcg gcctcagtga gcgagcgagc gcgcag                               4356


<210> 65
<211> 4758
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Rho.sgRNA-sgRNAscaffold-hU6-Opn1mw.sgRNA#1truncated-sgRNA
      scaffold-hU6-Opn1mw.sgRNA#2truncated-sgRNAscaffold-CMV-NLS-Cas9N-
      RmaIntN-SV40pA-ITR

<400> 65
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtacggtgac      480

gtagagcgtg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgg ggcctttaag      840

gtagttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      900

agtggcaccg agtcggtgct ttttttgtta acgagggcct atttcccatg attccttcat      960

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     1020

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     1080

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     1140

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgccacccct gtggatgttt     1200

tagagctaga aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca     1260

ccgagtcggt gcttttttta tttaaatagc tagcacgcgt tgacattgat tattgactag     1320

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt     1380

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac     1440

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg     1500

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag     1560

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat     1620

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat     1680

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt     1740

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga     1800

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg     1860

gtgggaggtc tatataagca gagctcgttt agtgaaccgt cagaaccggt cgactagagg     1920

atccatggcc ccaaagaaga agcggaaggt cggtatccac ggagtcccag cagccgacaa     1980

gaagtactcc attgggctcg atatcggcac aaacagcgtc ggctgggccg tcattacgga     2040

cgagtacaag gtgccgagca aaaaattcaa agttctgggc aataccgatc gccacagcat     2100

aaagaagaac ctcattggcg ccctcctgtt cgactccggg gaaacggccg aagccacgcg     2160

gctcaaaaga acagcacggc gcagatatac ccgcagaaag aatcggatct gctacctgca     2220

ggagatcttt agtaatgaga tggctaaggt ggatgactct ttcttccata ggctggagga     2280

gtcctttttg gtggaggagg ataaaaagca cgagcgccac ccaatctttg gcaatatcgt     2340

ggacgaggtg gcgtaccatg aaaagtaccc aaccatatat catctgagga agaagcttgt     2400

agacagtact gataaggctg acttgcggtt gatctatctc gcgctggcgc atatgatcaa     2460

atttcgggga cacttcctca tcgaggggga cctgaaccca gacaacagcg atgtcgacaa     2520

actctttatc caactggttc agacttacaa tcagcttttc gaagagaacc cgatcaacgc     2580

atccggagtt gacgccaaag caatcctgag cgctaggctg tccaaatccc ggcggctcga     2640

aaacctcatc gcacagctcc ctggggagaa gaagaacggc ctgtttggta atcttatcgc     2700

cctgtcactc gggctgaccc ccaactttaa atctaacttc gacctggccg aagatgccaa     2760

gcttcaactg agcaaagaca cctacgatga tgatctcgac aatctgctgg cccagatcgg     2820

cgaccagtac gcagaccttt ttttggcggc aaagaacctg tcagacgcca ttctgctgag     2880

tgatattctg cgagtgaaca cggagatcac caaagctccg ctgagcgcta gtatgatcaa     2940

gcgctatgat gagcaccacc aagacttgac tttgctgaag gcccttgtca gacagcaact     3000

gcctgagaag tacaaggaaa ttttcttcga tcagtctaaa aatggctacg ccggatacat     3060

tgacggcgga gcaagccagg aggaatttta caaatttatt aagcccatct tggaaaaaat     3120

ggacggcacc gaggagctgc tggtaaagct taacagagaa gatctgttgc gcaaacagcg     3180

cactttcgac aatggaagca tcccccacca gattcacctg ggcgaactgc acgctatcct     3240

caggcggcaa gaggatttct accccttttt gaaagataac agggaaaaga ttgagaaaat     3300

cctcacattt cggataccct actatgtagg ccccctcgcc cggggaaatt ccagattcgc     3360

gtggatgact cgcaaatcag aagagaccat cactccctgg aacttcgagg aagtcgtgga     3420

taagggggcc tctgcccagt ccttcatcga aaggatgact aactttgata aaaatctgcc     3480

taacgaaaag gtgcttccta aacactctct gctgtacgag tacttcacag tttataacga     3540

gctcaccaag gtcaaatacg tcacagaagg gatgagaaag ccagcattcc tgtctggaga     3600

gcagaagaaa gctatcgtgg acctcctctt caagacgaac cggaaagtta ccgtgaaaca     3660

gctcaaagaa gactatttca aaaagattga atgtttcgac tctgttgaaa tcagcggagt     3720

ggaggatcgc ttcaacgcat ccctgggaac gtatcacgat ctcctgaaaa tcattaaaga     3780

caaggacttc ctggacaatg aggagaacga ggacattctt gaggacattg tcctcaccct     3840

tacgttgttt gaagataggg agatgattga agaacgcttg aaaacttacg ctcatctctt     3900

cgacgacaaa gtcatgaaac agctcaagag gcgccgatat acaggatggg ggcggctgtc     3960

aagaaaactg atcaatggga tccgagacaa gcagagtgga aagacaatcc tggattttct     4020

taagtccgat ggatttgcca accggaactt catgcagttg atccatgatg actctctcac     4080

ctttaaggag gacatccaga aagcacaagt ttgtctggct ggcgatactc tcattaccct     4140

ggccgatgga cgacgagtgc ctattagaga actggtgtca cagcagaatt tttccgtgtg     4200

ggctctgaat cctcagactt accgcctgga gagggctaga gtgagtagag ctttctgtac     4260

cggcatcaaa cctgtgtacc gcctcaccac tagactgggg agatccatta gggccactgc     4320

caaccaccga tttctcacac ctcagggctg gaaacgagtc gatgaactcc agcctggaga     4380

ttacctggct ctgcctagga gaatccctac tgcctcctga tctcgagctc gatgagtttg     4440

gacaaaccac aactagaatg cagtgaaaaa aatgctttat ttgtgaaatt tgtgatgcta     4500

ttgctttatt tgtaaccatt ataagctgca ataaacaagt tctcgagtta agggcgaatt     4560

cccgattagg atcttcctag agcatggcta cgtagataag tagcatggcg ggttaatcat     4620

taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg ctcgctcgct     4680

cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg cggcctcagt     4740

gagcgagcga gcgcgcag                                                   4758


<210> 66
<211> 4350
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Rho.sgRNA-sgRNAscaffold-hU6-Opn1mw.sgRNA#1truncated-sgRNA
      scaffold-hU6-Opn1mw.sgRNA#2truncated-sgRNAscaffold-hRHO-NLS-Cas9N
      -RmaIntN-pA-ITR

<400> 66
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtacggtgac      480

gtagagcgtg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgg ggcctttaag      840

gtagttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      900

agtggcaccg agtcggtgct ttttttgtta acgagggcct atttcccatg attccttcat      960

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     1020

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     1080

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     1140

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgccacccct gtggatgttt     1200

tagagctaga aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca     1260

ccgagtcggt gcttttttta tttaaatagc tagccctctc ctccctgacc tcaggcttcc     1320

tcctagtgtc accttggccc ctcttagaag ccaattaggc cctcagtttc tgcagcgggg     1380

attaatatga ttatgaacac ccccaatctc ccagatgctg attcagccag gagcttagga     1440

gggggaggtc actttataag ggtctggggg ggtcagaacc cagagtcatc ggtaccaccg     1500

gtcgactaga ggatccatgg ccccaaagaa gaagcggaag gtcggtatcc acggagtccc     1560

agcagccgac aagaagtact ccattgggct cgatatcggc acaaacagcg tcggctgggc     1620

cgtcattacg gacgagtaca aggtgccgag caaaaaattc aaagttctgg gcaataccga     1680

tcgccacagc ataaagaaga acctcattgg cgccctcctg ttcgactccg gggaaacggc     1740

cgaagccacg cggctcaaaa gaacagcacg gcgcagatat acccgcagaa agaatcggat     1800

ctgctacctg caggagatct ttagtaatga gatggctaag gtggatgact ctttcttcca     1860

taggctggag gagtcctttt tggtggagga ggataaaaag cacgagcgcc acccaatctt     1920

tggcaatatc gtggacgagg tggcgtacca tgaaaagtac ccaaccatat atcatctgag     1980

gaagaagctt gtagacagta ctgataaggc tgacttgcgg ttgatctatc tcgcgctggc     2040

gcatatgatc aaatttcggg gacacttcct catcgagggg gacctgaacc cagacaacag     2100

cgatgtcgac aaactcttta tccaactggt tcagacttac aatcagcttt tcgaagagaa     2160

cccgatcaac gcatccggag ttgacgccaa agcaatcctg agcgctaggc tgtccaaatc     2220

ccggcggctc gaaaacctca tcgcacagct ccctggggag aagaagaacg gcctgtttgg     2280

taatcttatc gccctgtcac tcgggctgac ccccaacttt aaatctaact tcgacctggc     2340

cgaagatgcc aagcttcaac tgagcaaaga cacctacgat gatgatctcg acaatctgct     2400

ggcccagatc ggcgaccagt acgcagacct ttttttggcg gcaaagaacc tgtcagacgc     2460

cattctgctg agtgatattc tgcgagtgaa cacggagatc accaaagctc cgctgagcgc     2520

tagtatgatc aagcgctatg atgagcacca ccaagacttg actttgctga aggcccttgt     2580

cagacagcaa ctgcctgaga agtacaagga aattttcttc gatcagtcta aaaatggcta     2640

cgccggatac attgacggcg gagcaagcca ggaggaattt tacaaattta ttaagcccat     2700

cttggaaaaa atggacggca ccgaggagct gctggtaaag cttaacagag aagatctgtt     2760

gcgcaaacag cgcactttcg acaatggaag catcccccac cagattcacc tgggcgaact     2820

gcacgctatc ctcaggcggc aagaggattt ctaccccttt ttgaaagata acagggaaaa     2880

gattgagaaa atcctcacat ttcggatacc ctactatgta ggccccctcg cccggggaaa     2940

ttccagattc gcgtggatga ctcgcaaatc agaagagacc atcactccct ggaacttcga     3000

ggaagtcgtg gataaggggg cctctgccca gtccttcatc gaaaggatga ctaactttga     3060

taaaaatctg cctaacgaaa aggtgcttcc taaacactct ctgctgtacg agtacttcac     3120

agtttataac gagctcacca aggtcaaata cgtcacagaa gggatgagaa agccagcatt     3180

cctgtctgga gagcagaaga aagctatcgt ggacctcctc ttcaagacga accggaaagt     3240

taccgtgaaa cagctcaaag aagactattt caaaaagatt gaatgtttcg actctgttga     3300

aatcagcgga gtggaggatc gcttcaacgc atccctggga acgtatcacg atctcctgaa     3360

aatcattaaa gacaaggact tcctggacaa tgaggagaac gaggacattc ttgaggacat     3420

tgtcctcacc cttacgttgt ttgaagatag ggagatgatt gaagaacgct tgaaaactta     3480

cgctcatctc ttcgacgaca aagtcatgaa acagctcaag aggcgccgat atacaggatg     3540

ggggcggctg tcaagaaaac tgatcaatgg gatccgagac aagcagagtg gaaagacaat     3600

cctggatttt cttaagtccg atggatttgc caaccggaac ttcatgcagt tgatccatga     3660

tgactctctc acctttaagg aggacatcca gaaagcacaa gtttgtctgg ctggcgatac     3720

tctcattacc ctggccgatg gacgacgagt gcctattaga gaactggtgt cacagcagaa     3780

tttttccgtg tgggctctga atcctcagac ttaccgcctg gagagggcta gagtgagtag     3840

agctttctgt accggcatca aacctgtgta ccgcctcacc actagactgg ggagatccat     3900

tagggccact gccaaccacc gatttctcac acctcagggc tggaaacgag tcgatgaact     3960

ccagcctgga gattacctgg ctctgcctag gagaatccct actgcctcct gatctcgagc     4020

tcgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt atttgtgaaa     4080

tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa gttctcgagt     4140

taagggcgaa ttcccgatta ggatcttcct agagcatggc tacgtagata agtagcatgg     4200

cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc cctctctgcg     4260

cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg gctttgcccg     4320

ggcggcctca gtgagcgagc gagcgcgcag                                      4350


<210> 67
<211> 4946
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-CMV-RmaIntC-Cas9C-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 67
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcac gcgttgacat      240

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat      300

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac      360

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc      420

cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg      480

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat      540

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc      600

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt      660

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac      720

caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc      780

ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagagg      840

taccaccggt cgactagagg atccatggcg gcggcgtgcc cggaactgcg tcagctggcg      900

cagagcgatg tgtattggga tccgattgtg agcattgaac cggatggcgt ggaagaagtg      960

tttgatctga ccgtgccggg cccgcataac tttgtggcga acgatattat tgcgcataac     1020

tctggccagg gggacagtct tcacgagcac atcgctaatc ttgcaggtag cccagctatc     1080

aaaaagggaa tactgcagac cgttaaggtc gtggatgaac tcgtcaaagt aatgggaagg     1140

cataagcccg agaatatcgt tatcgagatg gcccgagaga accaaactac ccagaaggga     1200

cagaagaaca gtagggaaag gatgaagagg attgaagagg gtataaaaga actggggtcc     1260

caaatcctta aggaacaccc agttgaaaac acccagcttc agaatgagaa gctctacctg     1320

tactacctgc agaacggcag ggacatgtac gtggatcagg aactggacat caatcggctc     1380

tccgactacg acgtggatca tatcgtgccc cagtcttttc tcaaagatga ttctattgat     1440

aataaagtgt tgacaagatc cgataaaaat agagggaaga gtgataacgt cccctcagaa     1500

gaagttgtca agaaaatgaa aaattattgg cggcagctgc tgaacgccaa actgatcaca     1560

caacggaagt tcgataatct gactaaggct gaacgaggtg gcctgtctga gttggataaa     1620

gccggcttca tcaaaaggca gcttgttgag acacgccaga tcaccaagca cgtggcccaa     1680

attctcgatt cacgcatgaa caccaagtac gatgaaaatg acaaactgat tcgagaggtg     1740

aaagttatta ctctgaagtc taagctggtc tcagatttca gaaaggactt tcagttttat     1800

aaggtgagag agatcaacaa ttaccaccat gcgcatgatg cctacctgaa tgcagtggta     1860

ggcactgcac ttatcaaaaa atatcccaag cttgaatctg aatttgttta cggagactat     1920

aaagtgtacg atgttaggaa aatgatcgca aagtctgagc aggaaatagg caaggccacc     1980

gctaagtact tcttttacag caatattatg aattttttca agaccgagat tacactggcc     2040

aatggagaga ttcggaagcg accacttatc gaaacaaacg gagaaacagg agaaatcgtg     2100

tgggacaagg gtagggattt cgcgacagtc cggaaggtcc tgtccatgcc gcaggtgaac     2160

atcgttaaaa agaccgaagt acagaccgga ggcttctcca aggaaagtat cctcccgaaa     2220

aggaacagcg acaagctgat cgcacgcaaa aaagattggg accccaagaa atacggcgga     2280

ttcgattctc ctacagtcgc ttacagtgta ctggttgtgg ccaaagtgga gaaagggaag     2340

tctaaaaaac tcaaaagcgt caaggaactg ctgggcatca caatcatgga gcgatcaagc     2400

ttcgaaaaaa accccatcga ctttctcgag gcgaaaggat ataaagaggt caaaaaagac     2460

ctcatcatta agcttcccaa gtactctctc tttgagcttg aaaacggccg gaaacgaatg     2520

ctcgctagtg cgggcgagct gcagaaaggt aacgagctgg cactgccctc taaatacgtt     2580

aatttcttgt atctggccag ccactatgaa aagctcaaag ggtctcccga agataatgag     2640

cagaagcagc tgttcgtgga acaacacaaa cactaccttg atgagatcat cgagcaaata     2700

agcgaattct ccaaaagagt gatcctcgcc gacgctaacc tcgataaggt gctttctgct     2760

tacaataagc acagggataa gcccatcagg gagcaggcag aaaacattat ccacttgttt     2820

actctgacca acttgggcgc gcctgcagcc ttcaagtact tcgacaccac catagacaga     2880

aagcggtaca cctctacaaa ggaggtcctg gacgccacac tgattcatca gtcaattacg     2940

gggctctatg aaacaagaat cgacctctct cagctcggtg gagacagcag ggctgacccc     3000

aagaagaaga ggaaggtgtc gccagggatc cgtcgacttg acgcgttgat atcaacaagt     3060

ttgtacaaaa aagcaggcta caaagaggcc agcggttccg gacgggctga cgcattggac     3120

gattttgatc tggatatgct gggaagtgac gccctcgatg attttgacct tgacatgctt     3180

ggttcggatg cccttgatga ctttgacctc gacatgctcg gcagtgacgc ccttgatgat     3240

ttcgacctgg acatgctgat taactctaga agttccggat ctccgaaaaa gaaacgcaaa     3300

gttggtagcc agtacctgcc cgacaccgac gaccggcacc ggatcgagga aaagcggaag     3360

cggacctacg agacattcaa gagcatcatg aagaagtccc ccttcagcgg ccccaccgac     3420

cctagacctc cacctagaag aatcgccgtg cccagcagat ccagcgccag cgtgccaaaa     3480

cctgcccccc agccttaccc cttcaccagc agcctgagca ccatcaacta cgacgagttc     3540

cctaccatgg tgttccccag cggccagatc tctcaggcct ctgctctggc tccagcccct     3600

cctcaggtgc tgcctcaggc tcctgctcct gcaccagctc cagccatggt gtctgcactg     3660

gctcaggcac cagcacccgt gcctgtgctg gctcctggac ctccacaggc tgtggctcca     3720

ccagccccta aacctacaca ggccggcgag ggcacactgt ctgaagctct gctgcagctg     3780

cagttcgacg acgaggatct gggagccctg ctgggaaaca gcaccgatcc tgccgtgttc     3840

accgacctgg ccagcgtgga caacagcgag ttccagcagc tgctgaacca gggcatccct     3900

gtggcccctc acaccaccga gcccatgctg atggaatacc ccgaggccat cacccggctc     3960

gtgacaggcg ctcagaggcc tcctgatcca gctcctgccc ctctgggagc accaggcctg     4020

cctaatggac tgctgtctgg cgacgaggac ttcagctcta tcgccgatat ggatttctca     4080

gccttgctgg gctctggcag cggcagccgg gattccaggg aagggatgtt tttgccgaag     4140

cctgaggccg gctccgctat tagtgacgtg tttgagggcc gcgaggtgtg ccagccaaaa     4200

cgaatccggc catttcatcc tccaggaagt ccatgggcca accgcccact ccccgccagc     4260

ctcgcaccaa caccaaccgg tccagtacat gagccagtcg ggtcactgac cccggcacca     4320

gtccctcagc cactggatcc agcgcccgca gtgactcccg aggccagtca cctgttggag     4380

gatcccgatg aagagacgag ccaggctgtc aaagcccttc gggagatggc cgatactgtg     4440

attccccaga aggaagaggc tgcaatctgt ggccaaatgg acctttccca tccgccccca     4500

aggggccatc tggatgagct gacaaccaca cttgagtcca tgaccgagga tctgaacctg     4560

gactcacccc tgaccccgga attgaacgag attctggata ccttcctgaa cgacgagtgc     4620

ctcttgcatg ccatgcatat cagcacagga ctgtccatct tcgacacatc tctgttttga     4680

caataaaata tctttatttt cattacatct gtgtgttggt tttttgtgtc tcgagttaag     4740

ggcgaattcc cgattaggat cttcctagag catggctacg tagataagta gcatggcggg     4800

ttaatcatta actacaagga acccctagtg atggagttgg ccactccctc tctgcgcgct     4860

cgctcgctca ctgaggccgg gcgaccaaag gtcgcccgac gcccgggctt tgcccgggcg     4920

gcctcagtga gcgagcgagc gcgcag                                          4946


<210> 68
<211> 4532
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hRHO-RmaIntC-Cas9C-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 68
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagccc tctcctccct      240

gacctcaggc ttcctcctag tgtcaccttg gcccctctta gaagccaatt aggccctcag      300

tttctgcagc ggggattaat atgattatga acacccccaa tctcccagat gctgattcag      360

ccaggagctt aggaggggga ggtcacttta taagggtctg ggggggtcag aacccagagt      420

catcggtacc accggtcgac tagaggatcc atggcggcgg cgtgcccgga actgcgtcag      480

ctggcgcaga gcgatgtgta ttgggatccg attgtgagca ttgaaccgga tggcgtggaa      540

gaagtgtttg atctgaccgt gccgggcccg cataactttg tggcgaacga tattattgcg      600

cataactctg gccaggggga cagtcttcac gagcacatcg ctaatcttgc aggtagccca      660

gctatcaaaa agggaatact gcagaccgtt aaggtcgtgg atgaactcgt caaagtaatg      720

ggaaggcata agcccgagaa tatcgttatc gagatggccc gagagaacca aactacccag      780

aagggacaga agaacagtag ggaaaggatg aagaggattg aagagggtat aaaagaactg      840

gggtcccaaa tccttaagga acacccagtt gaaaacaccc agcttcagaa tgagaagctc      900

tacctgtact acctgcagaa cggcagggac atgtacgtgg atcaggaact ggacatcaat      960

cggctctccg actacgacgt ggatcatatc gtgccccagt cttttctcaa agatgattct     1020

attgataata aagtgttgac aagatccgat aaaaatagag ggaagagtga taacgtcccc     1080

tcagaagaag ttgtcaagaa aatgaaaaat tattggcggc agctgctgaa cgccaaactg     1140

atcacacaac ggaagttcga taatctgact aaggctgaac gaggtggcct gtctgagttg     1200

gataaagccg gcttcatcaa aaggcagctt gttgagacac gccagatcac caagcacgtg     1260

gcccaaattc tcgattcacg catgaacacc aagtacgatg aaaatgacaa actgattcga     1320

gaggtgaaag ttattactct gaagtctaag ctggtctcag atttcagaaa ggactttcag     1380

ttttataagg tgagagagat caacaattac caccatgcgc atgatgccta cctgaatgca     1440

gtggtaggca ctgcacttat caaaaaatat cccaagcttg aatctgaatt tgtttacgga     1500

gactataaag tgtacgatgt taggaaaatg atcgcaaagt ctgagcagga aataggcaag     1560

gccaccgcta agtacttctt ttacagcaat attatgaatt ttttcaagac cgagattaca     1620

ctggccaatg gagagattcg gaagcgacca cttatcgaaa caaacggaga aacaggagaa     1680

atcgtgtggg acaagggtag ggatttcgcg acagtccgga aggtcctgtc catgccgcag     1740

gtgaacatcg ttaaaaagac cgaagtacag accggaggct tctccaagga aagtatcctc     1800

ccgaaaagga acagcgacaa gctgatcgca cgcaaaaaag attgggaccc caagaaatac     1860

ggcggattcg attctcctac agtcgcttac agtgtactgg ttgtggccaa agtggagaaa     1920

gggaagtcta aaaaactcaa aagcgtcaag gaactgctgg gcatcacaat catggagcga     1980

tcaagcttcg aaaaaaaccc catcgacttt ctcgaggcga aaggatataa agaggtcaaa     2040

aaagacctca tcattaagct tcccaagtac tctctctttg agcttgaaaa cggccggaaa     2100

cgaatgctcg ctagtgcggg cgagctgcag aaaggtaacg agctggcact gccctctaaa     2160

tacgttaatt tcttgtatct ggccagccac tatgaaaagc tcaaagggtc tcccgaagat     2220

aatgagcaga agcagctgtt cgtggaacaa cacaaacact accttgatga gatcatcgag     2280

caaataagcg aattctccaa aagagtgatc ctcgccgacg ctaacctcga taaggtgctt     2340

tctgcttaca ataagcacag ggataagccc atcagggagc aggcagaaaa cattatccac     2400

ttgtttactc tgaccaactt gggcgcgcct gcagccttca agtacttcga caccaccata     2460

gacagaaagc ggtacacctc tacaaaggag gtcctggacg ccacactgat tcatcagtca     2520

attacggggc tctatgaaac aagaatcgac ctctctcagc tcggtggaga cagcagggct     2580

gaccccaaga agaagaggaa ggtgtcgcca gggatccgtc gacttgacgc gttgatatca     2640

acaagtttgt acaaaaaagc aggctacaaa gaggccagcg gttccggacg ggctgacgca     2700

ttggacgatt ttgatctgga tatgctggga agtgacgccc tcgatgattt tgaccttgac     2760

atgcttggtt cggatgccct tgatgacttt gacctcgaca tgctcggcag tgacgccctt     2820

gatgatttcg acctggacat gctgattaac tctagaagtt ccggatctcc gaaaaagaaa     2880

cgcaaagttg gtagccagta cctgcccgac accgacgacc ggcaccggat cgaggaaaag     2940

cggaagcgga cctacgagac attcaagagc atcatgaaga agtccccctt cagcggcccc     3000

accgacccta gacctccacc tagaagaatc gccgtgccca gcagatccag cgccagcgtg     3060

ccaaaacctg ccccccagcc ttaccccttc accagcagcc tgagcaccat caactacgac     3120

gagttcccta ccatggtgtt ccccagcggc cagatctctc aggcctctgc tctggctcca     3180

gcccctcctc aggtgctgcc tcaggctcct gctcctgcac cagctccagc catggtgtct     3240

gcactggctc aggcaccagc acccgtgcct gtgctggctc ctggacctcc acaggctgtg     3300

gctccaccag cccctaaacc tacacaggcc ggcgagggca cactgtctga agctctgctg     3360

cagctgcagt tcgacgacga ggatctggga gccctgctgg gaaacagcac cgatcctgcc     3420

gtgttcaccg acctggccag cgtggacaac agcgagttcc agcagctgct gaaccagggc     3480

atccctgtgg cccctcacac caccgagccc atgctgatgg aataccccga ggccatcacc     3540

cggctcgtga caggcgctca gaggcctcct gatccagctc ctgcccctct gggagcacca     3600

ggcctgccta atggactgct gtctggcgac gaggacttca gctctatcgc cgatatggat     3660

ttctcagcct tgctgggctc tggcagcggc agccgggatt ccagggaagg gatgtttttg     3720

ccgaagcctg aggccggctc cgctattagt gacgtgtttg agggccgcga ggtgtgccag     3780

ccaaaacgaa tccggccatt tcatcctcca ggaagtccat gggccaaccg cccactcccc     3840

gccagcctcg caccaacacc aaccggtcca gtacatgagc cagtcgggtc actgaccccg     3900

gcaccagtcc ctcagccact ggatccagcg cccgcagtga ctcccgaggc cagtcacctg     3960

ttggaggatc ccgatgaaga gacgagccag gctgtcaaag cccttcggga gatggccgat     4020

actgtgattc cccagaagga agaggctgca atctgtggcc aaatggacct ttcccatccg     4080

cccccaaggg gccatctgga tgagctgaca accacacttg agtccatgac cgaggatctg     4140

aacctggact cacccctgac cccggaattg aacgagattc tggatacctt cctgaacgac     4200

gagtgcctct tgcatgccat gcatatcagc acaggactgt ccatcttcga cacatctctg     4260

ttttgacaat aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtctcga     4320

gttaagggcg aattcccgat taggatcttc ctagagcatg gctacgtaga taagtagcat     4380

ggcgggttaa tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg     4440

cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc     4500

cgggcggcct cagtgagcga gcgagcgcgc ag                                   4532


<210> 69
<211> 4660
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Rho.sgRNA-sgRNAscaffold-hU6-Opn1mw.sgRNA#1truncated-sgRNA
      scaffold-hU6-Opn1mw.sgRNA#2truncated-sgRNAscaffold-CMV-NLS-Cas9N-
      DSS-BDlacZ-pA-ITR

<400> 69
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtacggtgac      480

gtagagcgtg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgg ggcctttaag      840

gtagttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      900

agtggcaccg agtcggtgct ttttttgtta acgagggcct atttcccatg attccttcat      960

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     1020

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     1080

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     1140

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgccacccct gtggatgttt     1200

tagagctaga aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca     1260

ccgagtcggt gcttttttta tttaaatagc tagcacgcgt tgacattgat tattgactag     1320

ttattaatag taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt     1380

tacataactt acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac     1440

gtcaataatg acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg     1500

ggtggagtat ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag     1560

tacgccccct attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat     1620

gaccttatgg gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat     1680

ggtgatgcgg ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt     1740

tccaagtctc caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga     1800

ctttccaaaa tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg     1860

gtgggaggtc tatataagca gagctcgttt agtgaaccgt cagaaccggt cgactagagg     1920

atccatggcc ccaaagaaga agcggaaggt cggtatccac ggagtcccag cagccgacaa     1980

gaagtactcc attgggctcg atatcggcac aaacagcgtc ggctgggccg tcattacgga     2040

cgagtacaag gtgccgagca aaaaattcaa agttctgggc aataccgatc gccacagcat     2100

aaagaagaac ctcattggcg ccctcctgtt cgactccggg gaaacggccg aagccacgcg     2160

gctcaaaaga acagcacggc gcagatatac ccgcagaaag aatcggatct gctacctgca     2220

ggagatcttt agtaatgaga tggctaaggt ggatgactct ttcttccata ggctggagga     2280

gtcctttttg gtggaggagg ataaaaagca cgagcgccac ccaatctttg gcaatatcgt     2340

ggacgaggtg gcgtaccatg aaaagtaccc aaccatatat catctgagga agaagcttgt     2400

agacagtact gataaggctg acttgcggtt gatctatctc gcgctggcgc atatgatcaa     2460

atttcgggga cacttcctca tcgaggggga cctgaaccca gacaacagcg atgtcgacaa     2520

actctttatc caactggttc agacttacaa tcagcttttc gaagagaacc cgatcaacgc     2580

atccggagtt gacgccaaag caatcctgag cgctaggctg tccaaatccc ggcggctcga     2640

aaacctcatc gcacagctcc ctggggagaa gaagaacggc ctgtttggta atcttatcgc     2700

cctgtcactc gggctgaccc ccaactttaa atctaacttc gacctggccg aagatgccaa     2760

gcttcaactg agcaaagaca cctacgatga tgatctcgac aatctgctgg cccagatcgg     2820

cgaccagtac gcagaccttt ttttggcggc aaagaacctg tcagacgcca ttctgctgag     2880

tgatattctg cgagtgaaca cggagatcac caaagctccg ctgagcgcta gtatgatcaa     2940

gcgctatgat gagcaccacc aagacttgac tttgctgaag gcccttgtca gacagcaact     3000

gcctgagaag tacaaggaaa ttttcttcga tcagtctaaa aatggctacg ccggatacat     3060

tgacggcgga gcaagccagg aggaatttta caaatttatt aagcccatct tggaaaaaat     3120

ggacggcacc gaggagctgc tggtaaagct taacagagaa gatctgttgc gcaaacagcg     3180

cactttcgac aatggaagca tcccccacca gattcacctg ggcgaactgc acgctatcct     3240

caggcggcaa gaggatttct accccttttt gaaagataac agggaaaaga ttgagaaaat     3300

cctcacattt cggataccct actatgtagg ccccctcgcc cggggaaatt ccagattcgc     3360

gtggatgact cgcaaatcag aagagaccat cactccctgg aacttcgagg aagtcgtgga     3420

taagggggcc tctgcccagt ccttcatcga aaggatgact aactttgata aaaatctgcc     3480

taacgaaaag gtgcttccta aacactctct gctgtacgag tacttcacag tttataacga     3540

gctcaccaag gtcaaatacg tcacagaagg gatgagaaag ccagcattcc tgtctggaga     3600

gcagaagaaa gctatcgtgg acctcctctt caagacgaac cggaaagtta ccgtgaaaca     3660

gctcaaagaa gactatttca aaaagattga atgtttcgac tctgttgaaa tcagcggagt     3720

ggaggatcgc ttcaacgcat ccctgggaac gtatcacgat ctcctgaaaa tcattaaaga     3780

caaggacttc ctggacaatg aggagaacga ggacattctt gaggacattg tcctcaccct     3840

tacgttgttt gaagataggg agatgattga agaacgcttg aaaacttacg ctcatctctt     3900

cgacgacaaa gtcatgaaac agctcaagag gcgccgatat acaggatggg ggcggctgtc     3960

aagaaaactg atcaatggga tccgagacaa gcagagtgga aagacaatcc tggattttct     4020

taagtccgat ggatttgcca accggaactt catgcagttg atccatgatg actctctcac     4080

ctttaaggag gacatccaga aagcacaagt ttctggccag ggggacagtc ttcacgagca     4140

catcgctaat cttgcaggta agggcactga gcagaaggga agaagctccg ggggctcttt     4200

gtagggtgcg gccgcagtgc atcaaggcga tcacatcagt gaaaaaaagc cagacaggcg     4260

gttaaaccaa cgcagattaa acagcaggat gcaaaaattc gcaggtggtc agatggcggc     4320

cgctctagac tcgatgagtt tggacaaacc acaactagaa tgcagtgaaa aaaatgcttt     4380

atttgtgaaa tttgtgatgc tattgcttta tttgtaacca ttataagctg caataaacaa     4440

gttctcgagt taagggcgaa ttcccgatta ggatcttcct agagcatggc tacgtagata     4500

agtagcatgg cgggttaatc attaactaca aggaacccct agtgatggag ttggccactc     4560

cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc cgacgcccgg     4620

gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag                           4660


<210> 70
<211> 4252
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hU6-Rho.sgRNA-sgRNAscaffold-hU6-Opn1mw.sgRNA#1truncated-sgRNA
      scaffold-hU6-Opn1mw.sgRNA#2truncated-sgRNAscaffold-hRHO-NLS-Cas9N
      -DSS-BDlacZ-pA-ITR

<400> 70
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa cgagggccta tttcccatga      240

ttccttcata tttgcatata cgatacaagg ctgttagaga gataattgga attaatttga      300

ctgtaaacac aaagatatta gtacaaaata cgtgacgtag aaagtaataa tttcttgggt      360

agtttgcagt tttaaaatta tgttttaaaa tggactatca tatgcttacc gtaacttgaa      420

agtatttcga tttcttggct ttatatatct tgtggaaagg acgaaacacc gtacggtgac      480

gtagagcgtg gttttagagc tagaaatagc aagttaaaat aaggctagtc cgttatcaac      540

ttgaaaaagt ggcaccgagt cggtgctttt tttgtatacg agggcctatt tcccatgatt      600

ccttcatatt tgcatatacg atacaaggct gttagagaga taattggaat taatttgact      660

gtaaacacaa agatattagt acaaaatacg tgacgtagaa agtaataatt tcttgggtag      720

tttgcagttt taaaattatg ttttaaaatg gactatcata tgcttaccgt aacttgaaag      780

tatttcgatt tcttggcttt atatatcttg tggaaaggac gaaacaccgg ggcctttaag      840

gtagttttag agctagaaat agcaagttaa aataaggcta gtccgttatc aacttgaaaa      900

agtggcaccg agtcggtgct ttttttgtta acgagggcct atttcccatg attccttcat      960

atttgcatat acgatacaag gctgttagag agataattgg aattaatttg actgtaaaca     1020

caaagatatt agtacaaaat acgtgacgta gaaagtaata atttcttggg tagtttgcag     1080

ttttaaaatt atgttttaaa atggactatc atatgcttac cgtaacttga aagtatttcg     1140

atttcttggc tttatatatc ttgtggaaag gacgaaacac cgccacccct gtggatgttt     1200

tagagctaga aatagcaagt taaaataagg ctagtccgtt atcaacttga aaaagtggca     1260

ccgagtcggt gcttttttta tttaaatagc tagccctctc ctccctgacc tcaggcttcc     1320

tcctagtgtc accttggccc ctcttagaag ccaattaggc cctcagtttc tgcagcgggg     1380

attaatatga ttatgaacac ccccaatctc ccagatgctg attcagccag gagcttagga     1440

gggggaggtc actttataag ggtctggggg ggtcagaacc cagagtcatc ggtaccaccg     1500

gtcgactaga ggatccatgg ccccaaagaa gaagcggaag gtcggtatcc acggagtccc     1560

agcagccgac aagaagtact ccattgggct cgatatcggc acaaacagcg tcggctgggc     1620

cgtcattacg gacgagtaca aggtgccgag caaaaaattc aaagttctgg gcaataccga     1680

tcgccacagc ataaagaaga acctcattgg cgccctcctg ttcgactccg gggaaacggc     1740

cgaagccacg cggctcaaaa gaacagcacg gcgcagatat acccgcagaa agaatcggat     1800

ctgctacctg caggagatct ttagtaatga gatggctaag gtggatgact ctttcttcca     1860

taggctggag gagtcctttt tggtggagga ggataaaaag cacgagcgcc acccaatctt     1920

tggcaatatc gtggacgagg tggcgtacca tgaaaagtac ccaaccatat atcatctgag     1980

gaagaagctt gtagacagta ctgataaggc tgacttgcgg ttgatctatc tcgcgctggc     2040

gcatatgatc aaatttcggg gacacttcct catcgagggg gacctgaacc cagacaacag     2100

cgatgtcgac aaactcttta tccaactggt tcagacttac aatcagcttt tcgaagagaa     2160

cccgatcaac gcatccggag ttgacgccaa agcaatcctg agcgctaggc tgtccaaatc     2220

ccggcggctc gaaaacctca tcgcacagct ccctggggag aagaagaacg gcctgtttgg     2280

taatcttatc gccctgtcac tcgggctgac ccccaacttt aaatctaact tcgacctggc     2340

cgaagatgcc aagcttcaac tgagcaaaga cacctacgat gatgatctcg acaatctgct     2400

ggcccagatc ggcgaccagt acgcagacct ttttttggcg gcaaagaacc tgtcagacgc     2460

cattctgctg agtgatattc tgcgagtgaa cacggagatc accaaagctc cgctgagcgc     2520

tagtatgatc aagcgctatg atgagcacca ccaagacttg actttgctga aggcccttgt     2580

cagacagcaa ctgcctgaga agtacaagga aattttcttc gatcagtcta aaaatggcta     2640

cgccggatac attgacggcg gagcaagcca ggaggaattt tacaaattta ttaagcccat     2700

cttggaaaaa atggacggca ccgaggagct gctggtaaag cttaacagag aagatctgtt     2760

gcgcaaacag cgcactttcg acaatggaag catcccccac cagattcacc tgggcgaact     2820

gcacgctatc ctcaggcggc aagaggattt ctaccccttt ttgaaagata acagggaaaa     2880

gattgagaaa atcctcacat ttcggatacc ctactatgta ggccccctcg cccggggaaa     2940

ttccagattc gcgtggatga ctcgcaaatc agaagagacc atcactccct ggaacttcga     3000

ggaagtcgtg gataaggggg cctctgccca gtccttcatc gaaaggatga ctaactttga     3060

taaaaatctg cctaacgaaa aggtgcttcc taaacactct ctgctgtacg agtacttcac     3120

agtttataac gagctcacca aggtcaaata cgtcacagaa gggatgagaa agccagcatt     3180

cctgtctgga gagcagaaga aagctatcgt ggacctcctc ttcaagacga accggaaagt     3240

taccgtgaaa cagctcaaag aagactattt caaaaagatt gaatgtttcg actctgttga     3300

aatcagcgga gtggaggatc gcttcaacgc atccctggga acgtatcacg atctcctgaa     3360

aatcattaaa gacaaggact tcctggacaa tgaggagaac gaggacattc ttgaggacat     3420

tgtcctcacc cttacgttgt ttgaagatag ggagatgatt gaagaacgct tgaaaactta     3480

cgctcatctc ttcgacgaca aagtcatgaa acagctcaag aggcgccgat atacaggatg     3540

ggggcggctg tcaagaaaac tgatcaatgg gatccgagac aagcagagtg gaaagacaat     3600

cctggatttt cttaagtccg atggatttgc caaccggaac ttcatgcagt tgatccatga     3660

tgactctctc acctttaagg aggacatcca gaaagcacaa gtttctggcc agggggacag     3720

tcttcacgag cacatcgcta atcttgcagg taagggcact gagcagaagg gaagaagctc     3780

cgggggctct ttgtagggtg cggccgcagt gcatcaaggc gatcacatca gtgaaaaaaa     3840

gccagacagg cggttaaacc aacgcagatt aaacagcagg atgcaaaaat tcgcaggtgg     3900

tcagatggcg gccgctctag actcgatgag tttggacaaa ccacaactag aatgcagtga     3960

aaaaaatgct ttatttgtga aatttgtgat gctattgctt tatttgtaac cattataagc     4020

tgcaataaac aagttctcga gttaagggcg aattcccgat taggatcttc ctagagcatg     4080

gctacgtaga taagtagcat ggcgggttaa tcattaacta caaggaaccc ctagtgatgg     4140

agttggccac tccctctctg cgcgctcgct cgctcactga ggccgggcga ccaaaggtcg     4200

cccgacgccc gggctttgcc cgggcggcct cagtgagcga gcgagcgcgc ag             4252


<210> 71
<211> 4882
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-CMV-BDlacZ-ASS-Cas9C-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 71
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagcac gcgttgacat      240

tgattattga ctagttatta atagtaatca attacggggt cattagttca tagcccatat      300

atggagttcc gcgttacata acttacggta aatggcccgc ctggctgacc gcccaacgac      360

ccccgcccat tgacgtcaat aatgacgtat gttcccatag taacgccaat agggactttc      420

cattgacgtc aatgggtgga gtatttacgg taaactgccc acttggcagt acatcaagtg      480

tatcatatgc caagtacgcc ccctattgac gtcaatgacg gtaaatggcc cgcctggcat      540

tatgcccagt acatgacctt atgggacttt cctacttggc agtacatcta cgtattagtc      600

atcgctatta ccatggtgat gcggttttgg cagtacatca atgggcgtgg atagcggttt      660

gactcacggg gatttccaag tctccacccc attgacgtca atgggagttt gttttggcac      720

caaaatcaac gggactttcc aaaatgtcgt aacaactccg ccccattgac gcaaatgggc      780

ggtaggcgtg tacggtggga ggtctatata agcagagctc gtttagtgaa ccgtcagagg      840

taccaccggt cgactagagg atcccggccg ccatctgacc acctgcgaat ttttgcatcc      900

tgctgtttaa tctgcgttgg tttaaccgcc tgtctggctt tttttcactg atgtgatcgc      960

cttgatgcac tcggccgcca acgagtcttt tgtcatctac aggtagccca gctatcaaaa     1020

agggaatact gcagaccgtt aaggtcgtgg atgaactcgt caaagtaatg ggaaggcata     1080

agcccgagaa tatcgttatc gagatggccc gagagaacca aactacccag aagggacaga     1140

agaacagtag ggaaaggatg aagaggattg aagagggtat aaaagaactg gggtcccaaa     1200

tccttaagga acacccagtt gaaaacaccc agcttcagaa tgagaagctc tacctgtact     1260

acctgcagaa cggcagggac atgtacgtgg atcaggaact ggacatcaat cggctctccg     1320

actacgacgt ggatcatatc gtgccccagt cttttctcaa agatgattct attgataata     1380

aagtgttgac aagatccgat aaaaatagag ggaagagtga taacgtcccc tcagaagaag     1440

ttgtcaagaa aatgaaaaat tattggcggc agctgctgaa cgccaaactg atcacacaac     1500

ggaagttcga taatctgact aaggctgaac gaggtggcct gtctgagttg gataaagccg     1560

gcttcatcaa aaggcagctt gttgagacac gccagatcac caagcacgtg gcccaaattc     1620

tcgattcacg catgaacacc aagtacgatg aaaatgacaa actgattcga gaggtgaaag     1680

ttattactct gaagtctaag ctggtctcag atttcagaaa ggactttcag ttttataagg     1740

tgagagagat caacaattac caccatgcgc atgatgccta cctgaatgca gtggtaggca     1800

ctgcacttat caaaaaatat cccaagcttg aatctgaatt tgtttacgga gactataaag     1860

tgtacgatgt taggaaaatg atcgcaaagt ctgagcagga aataggcaag gccaccgcta     1920

agtacttctt ttacagcaat attatgaatt ttttcaagac cgagattaca ctggccaatg     1980

gagagattcg gaagcgacca cttatcgaaa caaacggaga aacaggagaa atcgtgtggg     2040

acaagggtag ggatttcgcg acagtccgga aggtcctgtc catgccgcag gtgaacatcg     2100

ttaaaaagac cgaagtacag accggaggct tctccaagga aagtatcctc ccgaaaagga     2160

acagcgacaa gctgatcgca cgcaaaaaag attgggaccc caagaaatac ggcggattcg     2220

attctcctac agtcgcttac agtgtactgg ttgtggccaa agtggagaaa gggaagtcta     2280

aaaaactcaa aagcgtcaag gaactgctgg gcatcacaat catggagcga tcaagcttcg     2340

aaaaaaaccc catcgacttt ctcgaggcga aaggatataa agaggtcaaa aaagacctca     2400

tcattaagct tcccaagtac tctctctttg agcttgaaaa cggccggaaa cgaatgctcg     2460

ctagtgcggg cgagctgcag aaaggtaacg agctggcact gccctctaaa tacgttaatt     2520

tcttgtatct ggccagccac tatgaaaagc tcaaagggtc tcccgaagat aatgagcaga     2580

agcagctgtt cgtggaacaa cacaaacact accttgatga gatcatcgag caaataagcg     2640

aattctccaa aagagtgatc ctcgccgacg ctaacctcga taaggtgctt tctgcttaca     2700

ataagcacag ggataagccc atcagggagc aggcagaaaa cattatccac ttgtttactc     2760

tgaccaactt gggcgcgcct gcagccttca agtacttcga caccaccata gacagaaagc     2820

ggtacacctc tacaaaggag gtcctggacg ccacactgat tcatcagtca attacggggc     2880

tctatgaaac aagaatcgac ctctctcagc tcggtggaga cagcagggct gaccccaaga     2940

agaagaggaa ggtgtcgcca gggatccgtc gacttgacgc gttgatatca acaagtttgt     3000

acaaaaaagc aggctacaaa gaggccagcg gttccggacg ggctgacgca ttggacgatt     3060

ttgatctgga tatgctggga agtgacgccc tcgatgattt tgaccttgac atgcttggtt     3120

cggatgccct tgatgacttt gacctcgaca tgctcggcag tgacgccctt gatgatttcg     3180

acctggacat gctgattaac tctagaagtt ccggatctcc gaaaaagaaa cgcaaagttg     3240

gtagccagta cctgcccgac accgacgacc ggcaccggat cgaggaaaag cggaagcgga     3300

cctacgagac attcaagagc atcatgaaga agtccccctt cagcggcccc accgacccta     3360

gacctccacc tagaagaatc gccgtgccca gcagatccag cgccagcgtg ccaaaacctg     3420

ccccccagcc ttaccccttc accagcagcc tgagcaccat caactacgac gagttcccta     3480

ccatggtgtt ccccagcggc cagatctctc aggcctctgc tctggctcca gcccctcctc     3540

aggtgctgcc tcaggctcct gctcctgcac cagctccagc catggtgtct gcactggctc     3600

aggcaccagc acccgtgcct gtgctggctc ctggacctcc acaggctgtg gctccaccag     3660

cccctaaacc tacacaggcc ggcgagggca cactgtctga agctctgctg cagctgcagt     3720

tcgacgacga ggatctggga gccctgctgg gaaacagcac cgatcctgcc gtgttcaccg     3780

acctggccag cgtggacaac agcgagttcc agcagctgct gaaccagggc atccctgtgg     3840

cccctcacac caccgagccc atgctgatgg aataccccga ggccatcacc cggctcgtga     3900

caggcgctca gaggcctcct gatccagctc ctgcccctct gggagcacca ggcctgccta     3960

atggactgct gtctggcgac gaggacttca gctctatcgc cgatatggat ttctcagcct     4020

tgctgggctc tggcagcggc agccgggatt ccagggaagg gatgtttttg ccgaagcctg     4080

aggccggctc cgctattagt gacgtgtttg agggccgcga ggtgtgccag ccaaaacgaa     4140

tccggccatt tcatcctcca ggaagtccat gggccaaccg cccactcccc gccagcctcg     4200

caccaacacc aaccggtcca gtacatgagc cagtcgggtc actgaccccg gcaccagtcc     4260

ctcagccact ggatccagcg cccgcagtga ctcccgaggc cagtcacctg ttggaggatc     4320

ccgatgaaga gacgagccag gctgtcaaag cccttcggga gatggccgat actgtgattc     4380

cccagaagga agaggctgca atctgtggcc aaatggacct ttcccatccg cccccaaggg     4440

gccatctgga tgagctgaca accacacttg agtccatgac cgaggatctg aacctggact     4500

cacccctgac cccggaattg aacgagattc tggatacctt cctgaacgac gagtgcctct     4560

tgcatgccat gcatatcagc acaggactgt ccatcttcga cacatctctg ttttgacaat     4620

aaaatatctt tattttcatt acatctgtgt gttggttttt tgtgtctcga gttaagggcg     4680

aattcccgat taggatcttc ctagagcatg gctacgtaga taagtagcat ggcgggttaa     4740

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     4800

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     4860

cagtgagcga gcgagcgcgc ag                                              4882


<210> 72
<211> 4468
<212> DNA
<213> Artificial Sequence


<220> 
<223> ITR-hRHO-BDlacZ-ASS-Cas9C-NLS-VP64-NLS-p65-Rta-pA-ITR

<400> 72
ctgcgcgctc gctcgctcac tgaggccgcc cgggcaaagc ccgggcgtcg ggcgaccttt       60

ggtcgcccgg cctcagtgag cgagcgagcg cgcagagagg gagtggccaa ctccatcact      120

aggggttcct tgtagttaat gattaacccg ccatgctact tatctacgta gccatgctct      180

aggaagatcg gaattcgccc ttaagggcgc gccgtttaaa tagctagccc tctcctccct      240

gacctcaggc ttcctcctag tgtcaccttg gcccctctta gaagccaatt aggccctcag      300

tttctgcagc ggggattaat atgattatga acacccccaa tctcccagat gctgattcag      360

ccaggagctt aggaggggga ggtcacttta taagggtctg ggggggtcag aacccagagt      420

catcggtacc accggtcgac tagaggatcc cggccgccat ctgaccacct gcgaattttt      480

gcatcctgct gtttaatctg cgttggttta accgcctgtc tggctttttt tcactgatgt      540

gatcgccttg atgcactcgg ccgccaacga gtcttttgtc atctacaggt agcccagcta      600

tcaaaaaggg aatactgcag accgttaagg tcgtggatga actcgtcaaa gtaatgggaa      660

ggcataagcc cgagaatatc gttatcgaga tggcccgaga gaaccaaact acccagaagg      720

gacagaagaa cagtagggaa aggatgaaga ggattgaaga gggtataaaa gaactggggt      780

cccaaatcct taaggaacac ccagttgaaa acacccagct tcagaatgag aagctctacc      840

tgtactacct gcagaacggc agggacatgt acgtggatca ggaactggac atcaatcggc      900

tctccgacta cgacgtggat catatcgtgc cccagtcttt tctcaaagat gattctattg      960

ataataaagt gttgacaaga tccgataaaa atagagggaa gagtgataac gtcccctcag     1020

aagaagttgt caagaaaatg aaaaattatt ggcggcagct gctgaacgcc aaactgatca     1080

cacaacggaa gttcgataat ctgactaagg ctgaacgagg tggcctgtct gagttggata     1140

aagccggctt catcaaaagg cagcttgttg agacacgcca gatcaccaag cacgtggccc     1200

aaattctcga ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg attcgagagg     1260

tgaaagttat tactctgaag tctaagctgg tctcagattt cagaaaggac tttcagtttt     1320

ataaggtgag agagatcaac aattaccacc atgcgcatga tgcctacctg aatgcagtgg     1380

taggcactgc acttatcaaa aaatatccca agcttgaatc tgaatttgtt tacggagact     1440

ataaagtgta cgatgttagg aaaatgatcg caaagtctga gcaggaaata ggcaaggcca     1500

ccgctaagta cttcttttac agcaatatta tgaatttttt caagaccgag attacactgg     1560

ccaatggaga gattcggaag cgaccactta tcgaaacaaa cggagaaaca ggagaaatcg     1620

tgtgggacaa gggtagggat ttcgcgacag tccggaaggt cctgtccatg ccgcaggtga     1680

acatcgttaa aaagaccgaa gtacagaccg gaggcttctc caaggaaagt atcctcccga     1740

aaaggaacag cgacaagctg atcgcacgca aaaaagattg ggaccccaag aaatacggcg     1800

gattcgattc tcctacagtc gcttacagtg tactggttgt ggccaaagtg gagaaaggga     1860

agtctaaaaa actcaaaagc gtcaaggaac tgctgggcat cacaatcatg gagcgatcaa     1920

gcttcgaaaa aaaccccatc gactttctcg aggcgaaagg atataaagag gtcaaaaaag     1980

acctcatcat taagcttccc aagtactctc tctttgagct tgaaaacggc cggaaacgaa     2040

tgctcgctag tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc tctaaatacg     2100

ttaatttctt gtatctggcc agccactatg aaaagctcaa agggtctccc gaagataatg     2160

agcagaagca gctgttcgtg gaacaacaca aacactacct tgatgagatc atcgagcaaa     2220

taagcgaatt ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag gtgctttctg     2280

cttacaataa gcacagggat aagcccatca gggagcaggc agaaaacatt atccacttgt     2340

ttactctgac caacttgggc gcgcctgcag ccttcaagta cttcgacacc accatagaca     2400

gaaagcggta cacctctaca aaggaggtcc tggacgccac actgattcat cagtcaatta     2460

cggggctcta tgaaacaaga atcgacctct ctcagctcgg tggagacagc agggctgacc     2520

ccaagaagaa gaggaaggtg tcgccaggga tccgtcgact tgacgcgttg atatcaacaa     2580

gtttgtacaa aaaagcaggc tacaaagagg ccagcggttc cggacgggct gacgcattgg     2640

acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac cttgacatgc     2700

ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac gcccttgatg     2760

atttcgacct ggacatgctg attaactcta gaagttccgg atctccgaaa aagaaacgca     2820

aagttggtag ccagtacctg cccgacaccg acgaccggca ccggatcgag gaaaagcgga     2880

agcggaccta cgagacattc aagagcatca tgaagaagtc ccccttcagc ggccccaccg     2940

accctagacc tccacctaga agaatcgccg tgcccagcag atccagcgcc agcgtgccaa     3000

aacctgcccc ccagccttac cccttcacca gcagcctgag caccatcaac tacgacgagt     3060

tccctaccat ggtgttcccc agcggccaga tctctcaggc ctctgctctg gctccagccc     3120

ctcctcaggt gctgcctcag gctcctgctc ctgcaccagc tccagccatg gtgtctgcac     3180

tggctcaggc accagcaccc gtgcctgtgc tggctcctgg acctccacag gctgtggctc     3240

caccagcccc taaacctaca caggccggcg agggcacact gtctgaagct ctgctgcagc     3300

tgcagttcga cgacgaggat ctgggagccc tgctgggaaa cagcaccgat cctgccgtgt     3360

tcaccgacct ggccagcgtg gacaacagcg agttccagca gctgctgaac cagggcatcc     3420

ctgtggcccc tcacaccacc gagcccatgc tgatggaata ccccgaggcc atcacccggc     3480

tcgtgacagg cgctcagagg cctcctgatc cagctcctgc ccctctggga gcaccaggcc     3540

tgcctaatgg actgctgtct ggcgacgagg acttcagctc tatcgccgat atggatttct     3600

cagccttgct gggctctggc agcggcagcc gggattccag ggaagggatg tttttgccga     3660

agcctgaggc cggctccgct attagtgacg tgtttgaggg ccgcgaggtg tgccagccaa     3720

aacgaatccg gccatttcat cctccaggaa gtccatgggc caaccgccca ctccccgcca     3780

gcctcgcacc aacaccaacc ggtccagtac atgagccagt cgggtcactg accccggcac     3840

cagtccctca gccactggat ccagcgcccg cagtgactcc cgaggccagt cacctgttgg     3900

aggatcccga tgaagagacg agccaggctg tcaaagccct tcgggagatg gccgatactg     3960

tgattcccca gaaggaagag gctgcaatct gtggccaaat ggacctttcc catccgcccc     4020

caaggggcca tctggatgag ctgacaacca cacttgagtc catgaccgag gatctgaacc     4080

tggactcacc cctgaccccg gaattgaacg agattctgga taccttcctg aacgacgagt     4140

gcctcttgca tgccatgcat atcagcacag gactgtccat cttcgacaca tctctgtttt     4200

gacaataaaa tatctttatt ttcattacat ctgtgtgttg gttttttgtg tctcgagtta     4260

agggcgaatt cccgattagg atcttcctag agcatggcta cgtagataag tagcatggcg     4320

ggttaatcat taactacaag gaacccctag tgatggagtt ggccactccc tctctgcgcg     4380

ctcgctcgct cactgaggcc gggcgaccaa aggtcgcccg acgcccgggc tttgcccggg     4440

cggcctcagt gagcgagcga gcgcgcag                                        4468


<210> 73
<211> 150
<212> DNA
<213> Artificial Sequence


<220> 
<223> Vp64

<400> 73
gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac     60

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac    120

gcccttgatg atttcgacct ggacatgctg                                     150


<210> 74
<211> 375
<212> DNA
<213> Artificial Sequence


<220> 
<223> p65

<400> 74
cctacacagg ccggcgaggg cacactgtct gaagctctgc tgcagctgca gttcgacgac      60

gaggatctgg gagccctgct gggaaacagc accgatcctg ccgtgttcac cgacctggcc     120

agcgtggaca acagcgagtt ccagcagctg ctgaaccagg gcatccctgt ggcccctcac     180

accaccgagc ccatgctgat ggaatacccc gaggccatca cccggctcgt gacaggcgct     240

cagaggcctc ctgatccagc tcctgcccct ctgggagcac caggcctgcc taatggactg     300

ctgtctggcg acgaggactt cagctctatc gccgatatgg atttctcagc cttgctgggc     360

tctggcagcg gcagc                                                      375


<210> 75
<211> 570
<212> DNA
<213> Artificial Sequence


<220> 
<223> Rta

<400> 75
cgggattcca gggaagggat gtttttgccg aagcctgagg ccggctccgc tattagtgac      60

gtgtttgagg gccgcgaggt gtgccagcca aaacgaatcc ggccatttca tcctccagga     120

agtccatggg ccaaccgccc actccccgcc agcctcgcac caacaccaac cggtccagta     180

catgagccag tcgggtcact gaccccggca ccagtccctc agccactgga tccagcgccc     240

gcagtgactc ccgaggccag tcacctgttg gaggatcccg atgaagagac gagccaggct     300

gtcaaagccc ttcgggagat ggccgatact gtgattcccc agaaggaaga ggctgcaatc     360

tgtggccaaa tggacctttc ccatccgccc ccaaggggcc atctggatga gctgacaacc     420

acacttgagt ccatgaccga ggatctgaac ctggactcac ccctgacccc ggaattgaac     480

gagattctgg ataccttcct gaacgacgag tgcctcttgc atgccatgca tatcagcaca     540

ggactgtcca tcttcgacac atctctgttt                                      570


<210> 76
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgCnga1_1

<400> 76
taggcgaccg gctttgagaa agg                                            23


<210> 77
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgCnga1_2

<400> 77
ctgtggaagt ctccaaacgc tgg                                            23


<210> 78
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgCnga1_3

<400> 78
tcttctctct cggcgctatg cgg                                            23


<210> 79
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1mw_1

<400> 79
gtttgggggc ctttaaggta agg                                            23


<210> 80
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1mw_2

<400> 80
cctgagccac ccctgtggat tgg                                            23


<210> 81
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1mw_3

<400> 81
tagctcttgc ttgtttacaa ggg                                            23


<210> 82
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgRho

<400> 82
gtacggtgac gtagagcgtg agg                                            23


<210> 83
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1sw_1

<400> 83
gaacacaatc aatcagcttt ggg                                            23


<210> 84
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1sw_2

<400> 84
agcacccagc cttgttatcc agg                                            23


<210> 85
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1sw_3

<400> 85
agcatctttc acaaagggcc agg                                            23


<210> 86
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgUSH2A_1

<400> 86
tctatcaatg ggccaagctt tgg                                            23


<210> 87
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgUSH2A_2

<400> 87
agagggggga ttataggata agg                                            23


<210> 88
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgUSH2A_3

<400> 88
gaggtaccag cggaaagctt ggg                                            23


<210> 89
<211> 1500
<212> DNA
<213> Artificial Sequence


<220> 
<223> VP64-p65-Rta (VPR)

<400> 89
gacgcattgg acgattttga tctggatatg ctgggaagtg acgccctcga tgattttgac      60

cttgacatgc ttggttcgga tgcccttgat gactttgacc tcgacatgct cggcagtgac     120

gcccttgatg atttcgacct ggacatgctg cagtacctgc ccgacaccga cgaccggcac     180

cggatcgagg aaaagcggaa gcggacctac gagacattca agagcatcat gaagaagtcc     240

cccttcagcg gccccaccga ccctagacct ccacctagaa gaatcgccgt gcccagcaga     300

tccagcgcca gcgtgccaaa acctgccccc cagccttacc ccttcaccag cagcctgagc     360

accatcaact acgacgagtt ccctaccatg gtgttcccca gcggccagat ctctcaggcc     420

tctgctctgg ctccagcccc tcctcaggtg ctgcctcagg ctcctgctcc tgcaccagct     480

ccagccatgg tgtctgcact ggctcaggca ccagcacccg tgcctgtgct ggctcctgga     540

cctccacagg ctgtggctcc accagcccct aaacctacac aggccggcga gggcacactg     600

tctgaagctc tgctgcagct gcagttcgac gacgaggatc tgggagccct gctgggaaac     660

agcaccgatc ctgccgtgtt caccgacctg gccagcgtgg acaacagcga gttccagcag     720

ctgctgaacc agggcatccc tgtggcccct cacaccaccg agcccatgct gatggaatac     780

cccgaggcca tcacccggct cgtgacaggc gctcagaggc ctcctgatcc agctcctgcc     840

cctctgggag caccaggcct gcctaatgga ctgctgtctg gcgacgagga cttcagctct     900

atcgccgata tggatttctc agccttgctg cgggattcca gggaagggat gtttttgccg     960

aagcctgagg ccggctccgc tattagtgac gtgtttgagg gccgcgaggt gtgccagcca    1020

aaacgaatcc ggccatttca tcctccagga agtccatggg ccaaccgccc actccccgcc    1080

agcctcgcac caacaccaac cggtccagta catgagccag tcgggtcact gaccccggca    1140

ccagtccctc agccactgga tccagcgccc gcagtgactc ccgaggccag tcacctgttg    1200

gaggatcccg atgaagagac gagccaggct gtcaaagccc ttcgggagat ggccgatact    1260

gtgattcccc agaaggaaga ggctgcaatc tgtggccaaa tggacctttc ccatccgccc    1320

ccaaggggcc atctggatga gctgacaacc acacttgagt ccatgaccga ggatctgaac    1380

ctggactcac ccctgacccc ggaattgaac gagattctgg ataccttcct gaacgacgag    1440

tgcctcttgc atgccatgca tatcagcaca ggactgtcca tcttcgacac atctctgttt    1500


<210> 90
<211> 6002
<212> DNA
<213> Artificial Sequence


<220> 
<223> SAM (synergistic activation mediator)

<400> 90
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggac     4140

gcattggacg attttgatct ggatatgctg ggaagtgacg ccctcgatga ttttgacctt     4200

gacatgcttg gttcggatgc ccttgatgac tttgacctcg acatgctcgg cagtgacgcc     4260

cttgatgatt tcgacctgga catgctgatg gcttcaaact ttactcagtt cgtgctcgtg     4320

gacaatggtg ggacagggga tgtgacagtg gctccttcta atttcgctaa tggggtggca     4380

gagtggatca gctccaactc acggagccag gcctacaagg tgacatgcag cgtcaggcag     4440

tctagtgccc agaagagaaa gtataccatc aaggtggagg tccccaaagt ggctacccag     4500

acagtgggcg gagtcgaact gcctgtcgcc gcttggaggt cctacctgaa catggagctc     4560

actatcccaa ttttcgctac caattctgac tgtgaactca tcgtgaaggc aatgcagggg     4620

ctcctcaaag acggtaatcc tatcccttcc gccatcgccg ctaactcagg tatctaccct     4680

tcagggcaga tcagcaacca ggccctggct ctggccccta gctccgctcc agtgctggcc     4740

cagactatgg tgccctctag tgctatggtg cctctggccc agccacctgc tccagcccct     4800

gtgctgaccc caggaccacc ccagtcactg agcgctccag tgcccaagtc tacacaggcc     4860

ggcgagggga ctctgagtga agctctgctg cacctgcagt tcgacgctga tgaggacctg     4920

ggagctctgc tggggaacag caccgatccc ggagtgttca cagatctggc ctccgtggac     4980

aactctgagt ttcagcagct gctgaatcag ggcgtgtcca tgtctcatag tacagccgaa     5040

ccaatgctga tggagtaccc cgaagccatt acccggctgg tgaccggcag ccagcggccc     5100

cccgaccccg ctccaactcc cctgggaacc agcggcctgc ctaatgggct gtccggagat     5160

gaagacttct caagcatcgc tgatatggac tttagtgccc tgctgtcaca gatttcctct     5220

ggcttcagcg tggacaccag tgccctgctg gacctgttca gcccctcggt gaccgtgccc     5280

gacatgagcc tgcctgacct tgacagcagc ctggccagta tccaagagct cctgtctccc     5340

caggagcccc ccaggcctcc cgaggcagag aacagcagcc cggattcagg gaagcagctg     5400

gtgcactaca cagcgcagcc gctgttcctg ctggaccccg gctccgtgga caccgggagc     5460

aacgacctgc cggtgctgtt tgagctggga gagggctcct acttctccga aggggacggc     5520

ttcgccgagg accccaccat ctccctgctg acaggctcgg agcctcccaa agccaaggac     5580

cccactgtct ccgagggcct atttcccatg attccttcat atttgcatat acgatacaag     5640

gctgttagag agataattgg aattaatttg actgtaaaca caaagatatt agtacaaaat     5700

acgtgacgta gaaagtaata atttcttggg tagtttgcag ttttaaaatt atgttttaaa     5760

atggactatc atatgcttac cgtaacttga aagtatttcg atttcttggc tttatatatc     5820

ttgtggaaag gacgaaacac cgggtcttcg agaagacctg ttttagagct aggccaacat     5880

gaggatcacc catgtctgca gggcctagca agttaaaata aggctagtcc gttatcaact     5940

tggccaacat gaggatcacc catgtctgca gggccaagtg gcaccgagtc ggtgcttttt     6000

tt                                                                    6002


<210> 91
<211> 5823
<212> DNA
<213> Artificial Sequence


<220> 
<223> SunTag (dCas9(m2)-10xGCN4_v4-scFv-GCN4-VP64)

<400> 91
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggaa     4140

gaacttttga gcaagaatta tcatcttgag aacgaagtgg ctcgtcttaa gaaaggttct     4200

ggcagtggag aagaactgct ttcaaagaat taccacctgg aaaatgaggt agctagactg     4260

aaaaagggga gcggaagtgg ggaggagttg ctgagcaaaa attatcattt ggagaacgaa     4320

gtagcacgac taaagaaagg gtccggatcg ggtgaggagt tactctcgaa aaattatcat     4380

ctcgaaaacg aagtggctcg gctaaaaaag ggcagtggtt ctggagaaga gctattatct     4440

aaaaactacc acctcgaaaa tgaggtggca cgcttaaaaa agggaagtgg cagtggtgaa     4500

gagctactat ccaagaatta tcatcttgag aacgaggtag cgcgtttgaa gaagggttcc     4560

ggctcaggag aggaactgct ctcgaagaac tatcatcttg aaaatgaggt cgctcgatta     4620

aaaaagggat cgggcagtgg tgaggaacta ctttcaaaga attaccacct cgaaaacgaa     4680

gtagctcgat taaagaaagg ttcagggtcg ggtgaagaat tactgagtaa aaattatcat     4740

ctggaaaatg aggtagcgag actaaaaaag gggagtggtt ctggcgagga attgctatcg     4800

aaaaattatc atcttgagaa cgaagttgct aggctcaaaa agatgggccc cgacatcgtg     4860

atgacccaga gccccagcag cctgagcgcc agcgtgggcg accgcgtgac catcacctgc     4920

cgcagcagca ccggcgccgt gaccaccagc aactacgcca gctgggtgca ggagaagccc     4980

ggcaagctgt tcaagggcct gatcggcggc accaacaacc gcgcccccgg cgtgcccagc     5040

cgcttcagcg gcagcctgat cggcgacaag gccaccctga ccatcagcag cctgcagccc     5100

gaggacttcg ccacctactt ctgcgccctg tggtacagca accactgggt gttcggccag     5160

ggcaccaagg tggagctgaa gcgcggcggc ggcggcagcg gcggcggcgg cagcggcggc     5220

ggcggcagca gcggcggcgg cagcgaggtg aagctgctgg agagcggcgg cggcctggtg     5280

cagcccggcg gcagcctgaa gctgagctgc gccgtgagcg gcttcagcct gaccgactac     5340

ggcgtgaact gggtgcgcca ggcccccggc cgcggcctgg agtggatcgg cgtgatctgg     5400

ggcgacggca tcaccgacta caacagcgcc ctgaaggacc gcttcatcat cagcaaggac     5460

aacggcaaga acaccgtgta cctgcagatg agcaaggtgc gcagcgacga caccgccctg     5520

tactactgcg tgaccggcct gttcgactac tggggccagg gcaccctggt gaccgtgagc     5580

agctacccat acgatgttcc agattacgct ggtggaggcg gaggttctgg gggaggaggt     5640

agtggcggtg gtggttcagg aggcggcgga agcgatgctt tagacgattt tgacttagat     5700

atgcttggtt cagacgcgtt agacgacttc gacctagaca tgttaggctc agatgcattg     5760

gacgacttcg atttagatat gttgggctcc gatgccctag atgactttga tctagatatg     5820

cta                                                                   5823


<210> 92
<211> 4137
<212> DNA
<213> Streptococcus pyogenes


<400> 92
atggacaaga agtactccat tgggctcgat atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatcat     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtg        4137


<210> 93
<211> 3921
<212> DNA
<213> Acidaminococcus sp. BV3L6


<400> 93
atgacacagt tcgagggctt taccaacctg tatcaggtga gcaagacact gcggtttgag       60

ctgatcccac agggcaagac cctgaagcac atccaggagc agggcttcat cgaggaggac      120

aaggcccgca atgatcacta caaggagctg aagcccatca tcgatcggat ctacaagacc      180

tatgccgacc agtgcctgca gctggtgcag ctggattggg agaacctgag cgccgccatc      240

gactcctata gaaaggagaa aaccgaggag acaaggaacg ccctgatcga ggagcaggcc      300

acatatcgca atgccatcca cgactacttc atcggccgga cagacaacct gaccgatgcc      360

atcaataaga gacacgccga gatctacaag ggcctgttca aggccgagct gtttaatggc      420

aaggtgctga agcagctggg caccgtgacc acaaccgagc acgagaacgc cctgctgcgg      480

agcttcgaca agtttacaac ctacttctcc ggcttttatg agaacaggaa gaacgtgttc      540

agcgccgagg atatcagcac agccatccca caccgcatcg tgcaggacaa cttccccaag      600

tttaaggaga attgtcacat cttcacacgc ctgatcaccg ccgtgcccag cctgcgggag      660

cactttgaga acgtgaagaa ggccatcggc atcttcgtga gcacctccat cgaggaggtg      720

ttttccttcc ctttttataa ccagctgctg acacagaccc agatcgacct gtataaccag      780

ctgctgggag gaatctctcg ggaggcaggc accgagaaga tcaagggcct gaacgaggtg      840

ctgaatctgg ccatccagaa gaatgatgag acagcccaca tcatcgcctc cctgccacac      900

agattcatcc ccctgtttaa gcagatcctg tccgatagga acaccctgtc tttcatcctg      960

gaggagttta agagcgacga ggaagtgatc cagtccttct gcaagtacaa gacactgctg     1020

agaaacgaga acgtgctgga gacagccgag gccctgttta acgagctgaa cagcatcgac     1080

ctgacacaca tcttcatcag ccacaagaag ctggagacaa tcagcagcgc cctgtgcgac     1140

cactgggata cactgaggaa tgccctgtat gagcggagaa tctccgagct gacaggcaag     1200

atcaccaagt ctgccaagga gaaggtgcag cgcagcctga agcacgagga tatcaacctg     1260

caggagatca tctctgccgc aggcaaggag ctgagcgagg ccttcaagca gaaaaccagc     1320

gagatcctgt cccacgcaca cgccgccctg gatcagccac tgcctacaac cctgaagaag     1380

caggaggaga aggagatcct gaagtctcag ctggacagcc tgctgggcct gtaccacctg     1440

ctggactggt ttgccgtgga tgagtccaac gaggtggacc ccgagttctc tgcccggctg     1500

accggcatca agctggagat ggagccttct ctgagcttct acaacaaggc cagaaattat     1560

gccaccaaga agccctactc cgtggagaag ttcaagctga actttcagat gcctacactg     1620

gcctctggct gggacgtgaa taaggagaag aacaatggcg ccatcctgtt tgtgaagaac     1680

ggcctgtact atctgggcat catgccaaag cagaagggca ggtataaggc cctgagcttc     1740

gagcccacag agaaaaccag cgagggcttt gataagatgt actatgacta cttccctgat     1800

gccgccaaga tgatcccaaa gtgcagcacc cagctgaagg ccgtgacagc ccactttcag     1860

acccacacaa cccccatcct gctgtccaac aatttcatcg agcctctgga gatcacaaag     1920

gagatctacg acctgaacaa tcctgagaag gagccaaaga agtttcagac agcctacgcc     1980

aagaaaaccg gcgaccagaa gggctacaga gaggccctgt gcaagtggat cgacttcaca     2040

agggattttc tgtccaagta taccaagaca acctctatcg atctgtctag cctgcggcca     2100

tcctctcagt ataaggacct gggcgagtac tatgccgagc tgaatcccct gctgtaccac     2160

atcagcttcc agagaatcgc cgagaaggag atcatggatg ccgtggagac aggcaagctg     2220

tacctgttcc agatctataa caaggacttt gccaagggcc accacggcaa gcctaatctg     2280

cacacactgt attggaccgg cctgttttct ccagagaacc tggccaagac aagcatcaag     2340

ctgaatggcc aggccgagct gttctaccgc cctaagtcca ggatgaagag gatggcacac     2400

cggctgggag agaagatgct gaacaagaag ctgaaggatc agaaaacccc aatccccgac     2460

accctgtacc aggagctgta cgactatgtg aatcacagac tgtcccacga cctgtctgat     2520

gaggccaggg ccctgctgcc caacgtgatc accaaggagg tgtctcacga gatcatcaag     2580

gataggcgct ttaccagcga caagttcttt ttccacgtgc ctatcacact gaactatcag     2640

gccgccaatt ccccatctaa gttcaaccag agggtgaatg cctacctgaa ggagcacccc     2700

gagacaccta tcatcggcat cgatcggggc gagagaaacc tgatctatat cacagtgatc     2760

gactccaccg gcaagatcct ggagcagcgg agcctgaaca ccatccagca gtttgattac     2820

cagaagaagc tggacaacag ggagaaggag agggtggcag caaggcaggc ctggtctgtg     2880

gtgggcacaa tcaaggatct gaagcagggc tatctgagcc aggtcatcca cgagatcgtg     2940

gacctgatga tccactacca ggccgtggtg gtgctggaga acctgaattt cggctttaag     3000

agcaagagga ccggcatcgc cgagaaggcc gtgtaccagc agttcgagaa gatgctgatc     3060

gataagctga attgcctggt gctgaaggac tatccagcag agaaagtggg aggcgtgctg     3120

aacccatacc agctgacaga ccagttcacc tcctttgcca agatgggcac ccagtctggc     3180

ttcctgtttt acgtgcctgc cccatataca tctaagatcg atcccctgac cggcttcgtg     3240

gaccccttcg tgtggaaaac catcaagaat cacgagagcc gcaagcactt cctggagggc     3300

ttcgactttc tgcactacga cgtgaaaacc ggcgacttca tcctgcactt taagatgaac     3360

agaaatctgt ccttccagag gggcctgccc ggctttatgc ctgcatggga tatcgtgttc     3420

gagaagaacg agacacagtt tgacgccaag ggcacccctt tcatcgccgg caagagaatc     3480

gtgccagtga tcgagaatca cagattcacc ggcagatacc gggacctgta tcctgccaac     3540

gagctgatcg ccctgctgga ggagaagggc atcgtgttca gggatggctc caacatcctg     3600

ccaaagctgc tggagaatga cgattctcac gccatcgaca ccatggtggc cctgatccgc     3660

agcgtgctgc agatgcggaa ctccaatgcc gccacaggcg aggactatat caacagcccc     3720

gtgcgcgatc tgaatggcgt gtgcttcgac tcccggtttc agaacccaga gtggcccatg     3780

gacgccgatg ccaatggcgc ctaccacatc gccctgaagg gccagctgct gctgaatcac     3840

ctgaaggaga gcaaggatct gaagctgcag aacggcatct ccaatcagga ctggctggcc     3900

tacatccagg agctgcgcaa c                                               3921


<210> 94
<211> 3387
<212> DNA
<213> Alicyclobacillus acidiphilus


<400> 94
atggccgtga agagcatgaa ggtgaagctg cgcctggaca acatgcccga gatccgcgcc       60

ggcctgtgga agctgcacac cgaggtgaac gccggcgtgc gctactacac cgagtggctg      120

agcctgctgc gccaggagaa cctgtaccgc cgcagcccca acggcgacgg cgagcaggag      180

tgctacaaga ccgccgagga gtgcaaggcc gagctgctgg agcgcctgcg cgcccgccag      240

gtggagaacg gccactgcgg ccccgccggc agcgacgacg agctgctgca gctggcccgc      300

cagctgtacg agctgctggt gccccaggcc atcggcgcca agggcgacgc ccagcagatc      360

gcccgcaagt tcctgagccc cctggccgac aaggacgccg tgggcggcct gggcatcgcc      420

aaggccggca acaagccccg ctgggtgcgc atgcgcgagg ccggcgagcc cggctgggag      480

gaggagaagg ccaaggccga ggcccgcaag agcaccgacc gcaccgccga cgtgctgcgc      540

gccctggccg acttcggcct gaagcccctg atgcgcgtgt acaccgacag cgacatgagc      600

agcgtgcagt ggaagcccct gcgcaagggc caggccgtgc gcacctggga ccgcgacatg      660

ttccagcagg ccatcgagcg catgatgagc tgggagagct ggaaccagcg cgtgggcgag      720

gcctacgcca agctggtgga gcagaagagc cgcttcgagc agaagaactt cgtgggccag      780

gagcacctgg tgcagctggt gaaccagctg cagcaggaca tgaaggaggc cagccacggc      840

ctggagagca aggagcagac cgcccactac ctgaccggcc gcgccctgcg cggcagcgac      900

aaggtgttcg agaagtggga gaagctggac cccgacgccc ccttcgacct gtacgacacc      960

gagatcaaga acgtgcagcg ccgcaacacc cgccgcttcg gcagccacga cctgttcgcc     1020

aagctggccg agcccaagta ccaggccctg tggcgcgagg acgccagctt cctgacccgc     1080

tacgccgtgt acaacagcat cgtgcgcaag ctgaaccacg ccaagatgtt cgccaccttc     1140

accctgcccg acgccaccgc ccaccccatc tggacccgct tcgacaagct gggcggcaac     1200

ctgcaccagt acaccttcct gttcaacgag ttcggcgagg gccgccacgc catccgcttc     1260

cagaagctgc tgaccgtgga ggacggcgtg gccaaggagg tggacgacgt gaccgtgccc     1320

atcagcatga gcgcccagct ggacgacctg ctgccccgcg acccccacga gctggtggcc     1380

ctgtacttcc aggactacgg cgccgagcag cacctggccg gcgagttcgg cggcgccaag     1440

atccagtacc gccgcgacca gctgaaccac ctgcacgccc gccgcggcgc ccgcgacgtg     1500

tacctgaacc tgagcgtgcg cgtgcagagc cagagcgagg cccgcggcga gcgccgcccc     1560

ccctacgccg ccgtgttccg cctggtgggc gacaaccacc gcgccttcgt gcacttcgac     1620

aagctgagcg actacctggc cgagcacccc gacgacggca agctgggcag cgagggcctg     1680

ctgagcggcc tgcgcgtgat gagcgtggac ctgggcctgc gcaccagcgc cagcatcagc     1740

gtgttccgcg tggcccgcaa ggacgagctg aagcccaaca gcgagggccg cgtgcccttc     1800

tgcttcccca tcgagggcaa cgagaacctg gtggccgtgc acgagcgcag ccagctgctg     1860

aagctgcccg gcgagaccga gagcaaggac ctgcgcgcca tccgcgagga gcgccagcgc     1920

accctgcgcc agctgcgcac ccagctggcc tacctgcgcc tgctggtgcg ctgcggcagc     1980

gaggacgtgg gccgccgcga gcgcagctgg gccaagctga tcgagcagcc catggacgcc     2040

aaccagatga cccccgactg gcgcgaggcc ttcgaggacg agctgcagaa gctgaagagc     2100

ctgtacggca tctgcggcga ccgcgagtgg accgaggccg tgtacgagag cgtgcgccgc     2160

gtgtggcgcc acatgggcaa gcaggtgcgc gactggcgca aggacgtgcg cagcggcgag     2220

cgccccaaga tccgcggcta ccagaaggac gtggtgggcg gcaacagcat cgagcagatc     2280

gagtacctgg agcgccagta caagttcctg aagagctgga gcttcttcgg caaggtgagc     2340

ggccaggtga tccgcgccga gaagggcagc cgcttcgcca tcaccctgcg cgagcacatc     2400

gaccacgcca aggaggaccg cctgaagaag ctggccgacc gcatcatcat ggaggccctg     2460

ggctacgtgt acgccctgga cgacgagcgc ggcaagggca agtgggtggc caagtacccc     2520

ccctgccagc tgatcctgct ggaggagctg agcgagtacc agttcaacaa cgaccgcccc     2580

cccagcgaga acaaccagct gatgcagtgg agccaccgcg gcgtgttcca ggagctgctg     2640

aaccaggccc aggtgcacga cctgctggtg ggcaccatgt acgccgcctt cagcagccgc     2700

ttcgacgccc gcaccggcgc ccccggcatc cgctgccgcc gcgtgcccgc ccgctgcgcc     2760

cgcgagcaga accccgagcc cttcccctgg tggctgaaca agttcgtggc cgagcacaag     2820

ctggacggct gccccctgcg cgccgacgac ctgatcccca ccggcgaggg cgagttcttc     2880

gtgagcccct tcagcgccga ggagggcgac ttccaccaga tccacgccga cctgaacgcc     2940

gcccagaacc tgcagcgccg cctgtggagc gacttcgaca tcagccagat ccgcctgcgc     3000

tgcgactggg gcgaggtgga cggcgagccc gtgctgatcc cccgcaccac cggcaagcgc     3060

accgccgaca gctacggcaa caaggtgttc tacaccaaga ccggcgtgac ctactacgag     3120

cgcgagcgcg gcaagaagcg ccgcaaggtg ttcgcccagg aggagctgag cgaggaggag     3180

gccgagctgc tggtggaggc cgacgaggcc cgcgagaaga gcgtggtgct gatgcgcgac     3240

cccagcggca tcatcaaccg cggcgactgg acccgccaga aggagttctg gagcatggtg     3300

aaccagcgca tcgagggcta cctggtgaag cagatccgca gccgcgtgcg cctgcaggag     3360

agcgcctgcg agaacaccgg cgacatc                                         3387


<210> 95
<211> 5637
<212> DNA
<213> Artificial Sequence


<220> 
<223> dCas9(m2)-VPR

<400> 95
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtggac     4140

gcattggacg attttgatct ggatatgctg ggaagtgacg ccctcgatga ttttgacctt     4200

gacatgcttg gttcggatgc ccttgatgac tttgacctcg acatgctcgg cagtgacgcc     4260

cttgatgatt tcgacctgga catgctgcag tacctgcccg acaccgacga ccggcaccgg     4320

atcgaggaaa agcggaagcg gacctacgag acattcaaga gcatcatgaa gaagtccccc     4380

ttcagcggcc ccaccgaccc tagacctcca cctagaagaa tcgccgtgcc cagcagatcc     4440

agcgccagcg tgccaaaacc tgccccccag ccttacccct tcaccagcag cctgagcacc     4500

atcaactacg acgagttccc taccatggtg ttccccagcg gccagatctc tcaggcctct     4560

gctctggctc cagcccctcc tcaggtgctg cctcaggctc ctgctcctgc accagctcca     4620

gccatggtgt ctgcactggc tcaggcacca gcacccgtgc ctgtgctggc tcctggacct     4680

ccacaggctg tggctccacc agcccctaaa cctacacagg ccggcgaggg cacactgtct     4740

gaagctctgc tgcagctgca gttcgacgac gaggatctgg gagccctgct gggaaacagc     4800

accgatcctg ccgtgttcac cgacctggcc agcgtggaca acagcgagtt ccagcagctg     4860

ctgaaccagg gcatccctgt ggcccctcac accaccgagc ccatgctgat ggaatacccc     4920

gaggccatca cccggctcgt gacaggcgct cagaggcctc ctgatccagc tcctgcccct     4980

ctgggagcac caggcctgcc taatggactg ctgtctggcg acgaggactt cagctctatc     5040

gccgatatgg atttctcagc cttgctgcgg gattccaggg aagggatgtt tttgccgaag     5100

cctgaggccg gctccgctat tagtgacgtg tttgagggcc gcgaggtgtg ccagccaaaa     5160

cgaatccggc catttcatcc tccaggaagt ccatgggcca accgcccact ccccgccagc     5220

ctcgcaccaa caccaaccgg tccagtacat gagccagtcg ggtcactgac cccggcacca     5280

gtccctcagc cactggatcc agcgcccgca gtgactcccg aggccagtca cctgttggag     5340

gatcccgatg aagagacgag ccaggctgtc aaagcccttc gggagatggc cgatactgtg     5400

attccccaga aggaagaggc tgcaatctgt ggccaaatgg acctttccca tccgccccca     5460

aggggccatc tggatgagct gacaaccaca cttgagtcca tgaccgagga tctgaacctg     5520

gactcacccc tgaccccgga attgaacgag attctggata ccttcctgaa cgacgagtgc     5580

ctcttgcatg ccatgcatat cagcacagga ctgtccatct tcgacacatc tctgttt        5637


<210> 96
<211> 4137
<212> DNA
<213> Artificial Sequence


<220> 
<223> dCas9(m2) (D10A, H840A)

<400> 96
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggatgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaaaata gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtg        4137


<210> 97
<211> 4137
<212> DNA
<213> Artificial Sequence


<220> 
<223> dCas9(m4) (D10A, D839A, H840A, N863A)

<400> 97
atggacaaga agtactccat tgggctcgct atcggcacaa acagcgtcgg ctgggccgtc       60

attacggacg agtacaaggt gccgagcaaa aaattcaaag ttctgggcaa taccgatcgc      120

cacagcataa agaagaacct cattggcgcc ctcctgttcg actccgggga gacggccgaa      180

gccacgcggc tcaaaagaac agcacggcgc agatataccc gcagaaagaa tcggatctgc      240

tacctgcagg agatctttag taatgagatg gctaaggtgg atgactcttt cttccatagg      300

ctggaggagt cctttttggt ggaggaggat aaaaagcacg agcgccaccc aatctttggc      360

aatatcgtgg acgaggtggc gtaccatgaa aagtacccaa ccatatatca tctgaggaag      420

aagcttgtag acagtactga taaggctgac ttgcggttga tctatctcgc gctggcgcat      480

atgatcaaat ttcggggaca cttcctcatc gagggggacc tgaacccaga caacagcgat      540

gtcgacaaac tctttatcca actggttcag acttacaatc agcttttcga agagaacccg      600

atcaacgcat ccggagttga cgccaaagca atcctgagcg ctaggctgtc caaatcccgg      660

cggctcgaaa acctcatcgc acagctccct ggggagaaga agaacggcct gtttggtaat      720

cttatcgccc tgtcactcgg gctgaccccc aactttaaat ctaacttcga cctggccgaa      780

gatgccaagc ttcaactgag caaagacacc tacgatgatg atctcgacaa tctgctggcc      840

cagatcggcg accagtacgc agaccttttt ttggcggcaa agaacctgtc agacgccatt      900

ctgctgagtg atattctgcg agtgaacacg gagatcacca aagctccgct gagcgctagt      960

atgatcaagc gctatgatga gcaccaccaa gacttgactt tgctgaaggc ccttgtcaga     1020

cagcaactgc ctgagaagta caaggaaatt ttcttcgatc agtctaaaaa tggctacgcc     1080

ggatacattg acggcggagc aagccaggag gaattttaca aatttattaa gcccatcttg     1140

gaaaaaatgg acggcaccga ggagctgctg gtaaagctta acagagaaga tctgttgcgc     1200

aaacagcgca ctttcgacaa tggaagcatc ccccaccaga ttcacctggg cgaactgcac     1260

gctatcctca ggcggcaaga ggatttctac ccctttttga aagataacag ggaaaagatt     1320

gagaaaatcc tcacatttcg gataccctac tatgtaggcc ccctcgcccg gggaaattcc     1380

agattcgcgt ggatgactcg caaatcagaa gagaccatca ctccctggaa cttcgaggaa     1440

gtcgtggata agggggcctc tgcccagtcc ttcatcgaaa ggatgactaa ctttgataaa     1500

aatctgccta acgaaaaggt gcttcctaaa cactctctgc tgtacgagta cttcacagtt     1560

tataacgagc tcaccaaggt caaatacgtc acagaaggga tgagaaagcc agcattcctg     1620

tctggagagc agaagaaagc tatcgtggac ctcctcttca agacgaaccg gaaagttacc     1680

gtgaaacagc tcaaagaaga ctatttcaaa aagattgaat gtttcgactc tgttgaaatc     1740

agcggagtgg aggatcgctt caacgcatcc ctgggaacgt atcacgatct cctgaaaatc     1800

attaaagaca aggacttcct ggacaatgag gagaacgagg acattcttga ggacattgtc     1860

ctcaccctta cgttgtttga agatagggag atgattgaag aacgcttgaa aacttacgct     1920

catctcttcg acgacaaagt catgaaacag ctcaagaggc gccgatatac aggatggggg     1980

cggctgtcaa gaaaactgat caatgggatc cgagacaagc agagtggaaa gacaatcctg     2040

gattttctta agtccgatgg atttgccaac cggaacttca tgcagttgat ccatgatgac     2100

tctctcacct ttaaggagga catccagaaa gcacaagttt ctggccaggg ggacagtctt     2160

cacgagcaca tcgctaatct tgcaggtagc ccagctatca aaaagggaat actgcagacc     2220

gttaaggtcg tggatgaact cgtcaaagta atgggaaggc ataagcccga gaatatcgtt     2280

atcgagatgg cccgagagaa ccaaactacc cagaagggac agaagaacag tagggaaagg     2340

atgaagagga ttgaagaggg tataaaagaa ctggggtccc aaatccttaa ggaacaccca     2400

gttgaaaaca cccagcttca gaatgagaag ctctacctgt actacctgca gaacggcagg     2460

gacatgtacg tggatcagga actggacatc aatcggctct ccgactacga cgtggctgct     2520

atcgtgcccc agtcttttct caaagatgat tctattgata ataaagtgtt gacaagatcc     2580

gataaagcta gagggaagag tgataacgtc ccctcagaag aagttgtcaa gaaaatgaaa     2640

aattattggc ggcagctgct gaacgccaaa ctgatcacac aacggaagtt cgataatctg     2700

actaaggctg aacgaggtgg cctgtctgag ttggataaag ccggcttcat caaaaggcag     2760

cttgttgaga cacgccagat caccaagcac gtggcccaaa ttctcgattc acgcatgaac     2820

accaagtacg atgaaaatga caaactgatt cgagaggtga aagttattac tctgaagtct     2880

aagctggtct cagatttcag aaaggacttt cagttttata aggtgagaga gatcaacaat     2940

taccaccatg cgcatgatgc ctacctgaat gcagtggtag gcactgcact tatcaaaaaa     3000

tatcccaagc ttgaatctga atttgtttac ggagactata aagtgtacga tgttaggaaa     3060

atgatcgcaa agtctgagca ggaaataggc aaggccaccg ctaagtactt cttttacagc     3120

aatattatga attttttcaa gaccgagatt acactggcca atggagagat tcggaagcga     3180

ccacttatcg aaacaaacgg agaaacagga gaaatcgtgt gggacaaggg tagggatttc     3240

gcgacagtcc ggaaggtcct gtccatgccg caggtgaaca tcgttaaaaa gaccgaagta     3300

cagaccggag gcttctccaa ggaaagtatc ctcccgaaaa ggaacagcga caagctgatc     3360

gcacgcaaaa aagattggga ccccaagaaa tacggcggat tcgattctcc tacagtcgct     3420

tacagtgtac tggttgtggc caaagtggag aaagggaagt ctaaaaaact caaaagcgtc     3480

aaggaactgc tgggcatcac aatcatggag cgatcaagct tcgaaaaaaa ccccatcgac     3540

tttctcgagg cgaaaggata taaagaggtc aaaaaagacc tcatcattaa gcttcccaag     3600

tactctctct ttgagcttga aaacggccgg aaacgaatgc tcgctagtgc gggcgagctg     3660

cagaaaggta acgagctggc actgccctct aaatacgtta atttcttgta tctggccagc     3720

cactatgaaa agctcaaagg gtctcccgaa gataatgagc agaagcagct gttcgtggaa     3780

caacacaaac actaccttga tgagatcatc gagcaaataa gcgaattctc caaaagagtg     3840

atcctcgccg acgctaacct cgataaggtg ctttctgctt acaataagca cagggataag     3900

cccatcaggg agcaggcaga aaacattatc cacttgttta ctctgaccaa cttgggcgcg     3960

cctgcagcct tcaagtactt cgacaccacc atagacagaa agcggtacac ctctacaaag     4020

gaggtcctgg acgccacact gattcatcag tcaattacgg ggctctatga aacaagaatc     4080

gacctctctc agctcggtgg agacagcagg gctgacccca agaagaagag gaaggtg        4137


<210> 98
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_a_fwd primer

<400> 98
tgtttgctct gcagaatact t                                              21


<210> 99
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_a_rev

<400> 99
tttccgttgg ttgtggacta                                                20


<210> 100
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_b_for

<400> 100
gttggtactt catgggtttc a                                              21


<210> 101
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_b_rev

<400> 101
tggcattgcc tggagaaata                                                20


<210> 102
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_c_for

<400> 102
gatgtgtgag tgtgattcct t                                              21


<210> 103
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_c_rev

<400> 103
ttcctttaac cagaggtggc                                                20


<210> 104
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_d_for

<400> 104
cccaagaact atcttacact g                                              21


<210> 105
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_d_rev

<400> 105
caggtcacct caatgctgta t                                              21


<210> 106
<211> 19
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_e_for

<400> 106
agtcgaggac gtacaacag                                                 19


<210> 107
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_e_rev

<400> 107
actatgtgca ctgccaaatc c                                              21


<210> 108
<211> 17
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_f_for

<400> 108
gatgaggtct ggcgact                                                   17


<210> 109
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_f_rev

<400> 109
gagatgtcca gatgacacgt a                                              21


<210> 110
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_g_for

<400> 110
caggacttca tgcaacca                                                  18


<210> 111
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_g_rev

<400> 111
cttgggtagt agctgcaact a                                              21


<210> 112
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_h_for

<400> 112
tatcagctga aagcttgcac g                                              21


<210> 113
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_h_rev

<400> 113
ccgtcactga agatgttgta t                                              21


<210> 114
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_i_for

<400> 114
gtagaacaga aagagaatgg c                                              21


<210> 115
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_i_rev

<400> 115
catcaaaggt gcaatctcag                                                20


<210> 116
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_j_for

<400> 116
atagtaaacc agctgaagcc                                                20


<210> 117
<211> 20
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_j_rev

<400> 117
gttcatcagg tcctcttcat                                                20


<210> 118
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_k_for

<400> 118
ctcatggaca ttcaagacaa g                                              21


<210> 119
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_k_rev

<400> 119
gactatccct tactttacaa g                                              21


<210> 120
<211> 21
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_l_for

<400> 120
ctctgtctaa cacacaatag t                                              21


<210> 121
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> USH2A_l_rev

<400> 121
ggtcacattc aaatatttat taa                                            23


<210> 122
<211> 2448
<212> DNA
<213> Homo sapiens


<400> 122
atggcgggag ggcactgcgg cagcttcccc gcggcggcgg ccggcagcgg cgagatcgtc      60

caactgaacg taggggggac cagatttagt acctcaagac aaactcttat gtggattcca     120

gattcttttt tttccagttt gctgagtggg agaatttcaa cacttcgaga tgaaactggt     180

gctatattta ttgatagaga tccagcagca tttgcaccca ttttaaattt tcttcggaca     240

aaagaactag acttaagggg agtgagtatt aatgttctca ggcatgaagc agaattttac     300

gggatcactc cattagtaag aaggcttctc ttatgtgaag aattggagcg ttcctcttgt     360

ggcagtgtcc tttttcatgg ttacttgccc ccaccaggta ttcctagtcg taaaataaac     420

aacacagtca gatctgctga ttctaggaat ggtctaaatt ctacagaagg tgaagcccgg     480

ggaaatggta cacagcctgt tctctctgga acgggagaag aaactgttag gctaggattt     540

cctgtggatc cacgaaaggt gctaatagta gctggccatc acaactggat tgtagctgca     600

tatgcccatt ttgctgtgtg ttacagaatc aaagaatctt caggatggca gcaagtgttt     660

acgagcccat atttggattg gactatcgaa cgagtagctt taaatgcaaa ggtggttgga     720

gggccacatg gagacaaaga caaaatggtt gctgttgcct cagagagtag catcatcttg     780

tggagtgttc aggatggggg aagtggaagt gaaattggag tgttcagcct gggtgttcct     840

gtagatgctc tcttctttat tggtaaccag ttggtggcca cgagtcatac agggaaagtg     900

ggagtgtgga atgctgtcac tcagcactgg caggttcaag atgttgttcc tataactagt     960

tatgacactg ctggatcatt ccttctgctt ggatgtaaca atggatcaat atattacata    1020

gatatgcaga agttcccctt gcgaatgaaa gataatgatc ttcttgtaac tgaactgtat    1080

catgatcctt caaatgatgc tattactgct ctgagtgttt acctcacacc caaaacaagt    1140

gtcagtggta actggatcga gatcgcctat ggtacgagct ctggagcagt acgagtgatt    1200

gtacaacacc cagagacagt tgggtcaggt cctcagcttt ttcagacttt cacagttcac    1260

cgaagtcccg taacaaaaat catgctatca gagaagcatc ttgtatcagt ctgtgcagat    1320

aataatcatg tccggacgtg gacagtaaca cgattcagag gaatgatctc tactcagcca    1380

ggttctactc ctttagcgtc attcaagata ctatccctgg aggagacaga aagtcatggt    1440

agctattcct ctggaaatga cataggacct tttggagagc gagacgatca acaggtgttt    1500

atccagaaag ttgttcccat caccaacaaa ctatttgtaa gactctcatc gactggaaaa    1560

agaatatgtg agatccaggc tgttgactgt actacaatat cctcatttac agtgagggaa    1620

tgtgagggat ccagtaggat gggctcaaga ccaaggcgct acttgttcac aggccataca    1680

aatggcagta ttcaaatgtg ggatctgacc actgctatgg atatggttaa caaaagtgaa    1740

gataaggatg taggtggtcc aaccgaagaa gagctactca aattactcga tcaatgtgat    1800

ttgagcacat ctcgctgtgc tactcctaac atcagtccag caacttccgt agttcagcat    1860

agccacttac gagaatcaaa ttctagcctt cagcttcagc accatgatac cacccatgaa    1920

gcagctactt acggttccat gaggccttac agagaaagtc ctttattagc aagggcaaga    1980

aggactgaga gctttcacag ttatagggac ttccagacta ttaatttgaa cagaaatgta    2040

gaaagagctg tccctgaaaa tggtaacttg ggtccaatac aagctgaagt gaaaggggca    2100

acaggggaat gtaatatatc tgagagaaag tctcctggag tagaaataaa aagtttgaga    2160

gaattggata gtggattgga agtgcataaa atagctgaag gtttttcaga atccaagaaa    2220

aggtcatcag aagatgaaaa tgaaaataaa atagagttta ggaagaaagg aggatttgaa    2280

gggggaggat tccttggaag aaagaaagtt ccctatctgg cgtcatcacc aagtacttcc    2340

gatggaggaa ctgactcacc tggtactgcg tccccatctc ctacaaagac tactccatct    2400

cctcggcata aaaaaagtga ttcttcaggt caggagtaca gcttgtga                 2448


<210> 123
<211> 11178
<212> DNA
<213> Artificial Sequence


<220> 
<223> PiggyBac-TRE-dCas9-VPR-polyA-3xsgRNA.Cnga1-EF1a-rtTA-T2A-PuroR-po
      lyA

<400> 123
ttaaccctag aaagataatc atattgtgac gtacgttaaa gataatcatg cgtaaaattg       60

acgcatgtgt tttatcggtc tgtatatcga ggtttattta ttaatttgaa tagatattaa      120

gttttattat atttacactt acatactaat aataaattca acaaacaatt tatttatgtt      180

tatttattta ttaaaaaaaa acaaaaactc aaaatttctt ctataaagta acaaaacttt      240

tatgagggac agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag      300

ggggcagcag cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga      360

gccggcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct      420

gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaggcct      480

ccacggccac tagttttact ccctatcagt gatagagaac gtatgaagag tttactccct      540

atcagtgata gagaacgtat gcagacttta ctccctatca gtgatagaga acgtataagg      600

agtttactcc ctatcagtga tagagaacgt atgaccagtt tactccctat cagtgataga      660

gaacgtatct acagtttact ccctatcagt gatagagaac gtatatccag tttactccct      720

atcagtgata gagaacgtat aagctttagg cgtgtacggt gggcgcctat aaaagcagag      780

ctcgtttagt gaaccgtcag atcgcctgga gcaattccac aacacttttg tcttatacca      840

actttccgta ccacttccta ccctcgtaaa ggtctagagc tagcgaattc gaatttaaat      900

ctacgtagcc accatggaca agaagtactc cattgggctc gctatcggca caaacagcgt      960

cggctgggcc gtcattacgg acgagtacaa ggtgccgagc aaaaaattca aagttctggg     1020

caataccgat cgccacagca taaagaagaa cctcattggc gccctcctgt tcgactccgg     1080

ggagacggcc gaagccacgc ggctcaaaag aacagcacgg cgcagatata cccgcagaaa     1140

gaatcggatc tgctacctgc aggagatctt tagtaatgag atggctaagg tggatgactc     1200

tttcttccat aggctggagg agtccttttt ggtggaggag gataaaaagc acgagcgcca     1260

cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat gaaaagtacc caaccatata     1320

tcatctgagg aagaagcttg tagacagtac tgataaggct gacttgcggt tgatctatct     1380

cgcgctggcg catatgatca aatttcgggg acacttcctc atcgaggggg acctgaaccc     1440

agacaacagc gatgtcgaca aactctttat ccaactggtt cagacttaca atcagctttt     1500

cgaagagaac ccgatcaacg catccggagt tgacgccaaa gcaatcctga gcgctaggct     1560

gtccaaatcc cggcggctcg aaaacctcat cgcacagctc cctggggaga agaagaacgg     1620

cctgtttggt aatcttatcg ccctgtcact cgggctgacc cccaacttta aatctaactt     1680

cgacctggcc gaagatgcca agcttcaact gagcaaagac acctacgatg atgatctcga     1740

caatctgctg gcccagatcg gcgaccagta cgcagacctt tttttggcgg caaagaacct     1800

gtcagacgcc attctgctga gtgatattct gcgagtgaac acggagatca ccaaagctcc     1860

gctgagcgct agtatgatca agcgctatga tgagcaccac caagacttga ctttgctgaa     1920

ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa attttcttcg atcagtctaa     1980

aaatggctac gccggataca ttgacggcgg agcaagccag gaggaatttt acaaatttat     2040

taagcccatc ttggaaaaaa tggacggcac cgaggagctg ctggtaaagc ttaacagaga     2100

agatctgttg cgcaaacagc gcactttcga caatggaagc atcccccacc agattcacct     2160

gggcgaactg cacgctatcc tcaggcggca agaggatttc tacccctttt tgaaagataa     2220

cagggaaaag attgagaaaa tcctcacatt tcggataccc tactatgtag gccccctcgc     2280

ccggggaaat tccagattcg cgtggatgac tcgcaaatca gaagagacca tcactccctg     2340

gaacttcgag gaagtcgtgg ataagggggc ctctgcccag tccttcatcg aaaggatgac     2400

taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct aaacactctc tgctgtacga     2460

gtacttcaca gtttataacg agctcaccaa ggtcaaatac gtcacagaag ggatgagaaa     2520

gccagcattc ctgtctggag agcagaagaa agctatcgtg gacctcctct tcaagacgaa     2580

ccggaaagtt accgtgaaac agctcaaaga agactatttc aaaaagattg aatgtttcga     2640

ctctgttgaa atcagcggag tggaggatcg cttcaacgca tccctgggaa cgtatcacga     2700

tctcctgaaa atcattaaag acaaggactt cctggacaat gaggagaacg aggacattct     2760

tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg gagatgattg aagaacgctt     2820

gaaaacttac gctcatctct tcgacgacaa agtcatgaaa cagctcaaga ggcgccgata     2880

tacaggatgg gggcggctgt caagaaaact gatcaatggg atccgagaca agcagagtgg     2940

aaagacaatc ctggattttc ttaagtccga tggatttgcc aaccggaact tcatgcagtt     3000

gatccatgat gactctctca cctttaagga ggacatccag aaagcacaag tttctggcca     3060

gggggacagt cttcacgagc acatcgctaa tcttgcaggt agcccagcta tcaaaaaggg     3120

aatactgcag accgttaagg tcgtggatga actcgtcaaa gtaatgggaa ggcataagcc     3180

cgagaatatc gttatcgaga tggcccgaga gaaccaaact acccagaagg gacagaagaa     3240

cagtagggaa aggatgaaga ggattgaaga gggtataaaa gaactggggt cccaaatcct     3300

taaggaacac ccagttgaaa acacccagct tcagaatgag aagctctacc tgtactacct     3360

gcagaacggc agggacatgt acgtggatca ggaactggac atcaatcggc tctccgacta     3420

cgacgtggct gctatcgtgc cccagtcttt tctcaaagat gattctattg ataataaagt     3480

gttgacaaga tccgataaag ctagagggaa gagtgataac gtcccctcag aagaagttgt     3540

caagaaaatg aaaaattatt ggcggcagct gctgaacgcc aaactgatca cacaacggaa     3600

gttcgataat ctgactaagg ctgaacgagg tggcctgtct gagttggata aagccggctt     3660

catcaaaagg cagcttgttg agacacgcca gatcaccaag cacgtggccc aaattctcga     3720

ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg attcgagagg tgaaagttat     3780

tactctgaag tctaagctgg tctcagattt cagaaaggac tttcagtttt ataaggtgag     3840

agagatcaac aattaccacc atgcgcatga tgcctacctg aatgcagtgg taggcactgc     3900

acttatcaaa aaatatccca agcttgaatc tgaatttgtt tacggagact ataaagtgta     3960

cgatgttagg aaaatgatcg caaagtctga gcaggaaata ggcaaggcca ccgctaagta     4020

cttcttttac agcaatatta tgaatttttt caagaccgag attacactgg ccaatggaga     4080

gattcggaag cgaccactta tcgaaacaaa cggagaaaca ggagaaatcg tgtgggacaa     4140

gggtagggat ttcgcgacag tccggaaggt cctgtccatg ccgcaggtga acatcgttaa     4200

aaagaccgaa gtacagaccg gaggcttctc caaggaaagt atcctcccga aaaggaacag     4260

cgacaagctg atcgcacgca aaaaagattg ggaccccaag aaatacggcg gattcgattc     4320

tcctacagtc gcttacagtg tactggttgt ggccaaagtg gagaaaggga agtctaaaaa     4380

actcaaaagc gtcaaggaac tgctgggcat cacaatcatg gagcgatcaa gcttcgaaaa     4440

aaaccccatc gactttctcg aggcgaaagg atataaagag gtcaaaaaag acctcatcat     4500

taagcttccc aagtactctc tctttgagct tgaaaacggc cggaaacgaa tgctcgctag     4560

tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc tctaaatacg ttaatttctt     4620

gtatctggcc agccactatg aaaagctcaa agggtctccc gaagataatg agcagaagca     4680

gctgttcgtg gaacaacaca aacactacct tgatgagatc atcgagcaaa taagcgaatt     4740

ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag gtgctttctg cttacaataa     4800

gcacagggat aagcccatca gggagcaggc agaaaacatt atccacttgt ttactctgac     4860

caacttgggc gcgcctgcag ccttcaagta cttcgacacc accatagaca gaaagcggta     4920

cacctctaca aaggaggtcc tggacgccac actgattcat cagtcaatta cggggctcta     4980

tgaaacaaga atcgacctct ctcagctcgg tggagacagc agggctgacc ccaagaagaa     5040

gaggaaggtg tcgccaggga tccgtcgact tgacgcgttg atatcaacaa gtttgtacaa     5100

aaaagcaggc tacaaagagg ccagcggttc cggacgggct gacgcattgg acgattttga     5160

tctggatatg ctgggaagtg acgccctcga tgattttgac cttgacatgc ttggttcgga     5220

tgcccttgat gactttgacc tcgacatgct cggcagtgac gcccttgatg atttcgacct     5280

ggacatgctg attaactcta gaagttccgg atctccgaaa aagaaacgca aagttggtag     5340

ccagtacctg cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta     5400

cgagacattc aagagcatca tgaagaagtc ccccttcagc ggccccaccg accctagacc     5460

tccacctaga agaatcgccg tgcccagcag atccagcgcc agcgtgccaa aacctgcccc     5520

ccagccttac cccttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat     5580

ggtgttcccc agcggccaga tctctcaggc ctctgctctg gctccagccc ctcctcaggt     5640

gctgcctcag gctcctgctc ctgcaccagc tccagccatg gtgtctgcac tggctcaggc     5700

accagcaccc gtgcctgtgc tggctcctgg acctccacag gctgtggctc caccagcccc     5760

taaacctaca caggccggcg agggcacact gtctgaagct ctgctgcagc tgcagttcga     5820

cgacgaggat ctgggagccc tgctgggaaa cagcaccgat cctgccgtgt tcaccgacct     5880

ggccagcgtg gacaacagcg agttccagca gctgctgaac cagggcatcc ctgtggcccc     5940

tcacaccacc gagcccatgc tgatggaata ccccgaggcc atcacccggc tcgtgacagg     6000

cgctcagagg cctcctgatc cagctcctgc ccctctggga gcaccaggcc tgcctaatgg     6060

actgctgtct ggcgacgagg acttcagctc tatcgccgat atggatttct cagccttgct     6120

gggctctggc agcggcagcc gggattccag ggaagggatg tttttgccga agcctgaggc     6180

cggctccgct attagtgacg tgtttgaggg ccgcgaggtg tgccagccaa aacgaatccg     6240

gccatttcat cctccaggaa gtccatgggc caaccgccca ctccccgcca gcctcgcacc     6300

aacaccaacc ggtccagtac atgagccagt cgggtcactg accccggcac cagtccctca     6360

gccactggat ccagcgcccg cagtgactcc cgaggccagt cacctgttgg aggatcccga     6420

tgaagagacg agccaggctg tcaaagccct tcgggagatg gccgatactg tgattcccca     6480

gaaggaagag gctgcaatct gtggccaaat ggacctttcc catccgcccc caaggggcca     6540

tctggatgag ctgacaacca cacttgagtc catgaccgag gatctgaacc tggactcacc     6600

cctgaccccg gaattgaacg agattctgga taccttcctg aacgacgagt gcctcttgca     6660

tgccatgcat atcagcacag gactgtccat cttcgacaca tctctgtttt gaaacccagc     6720

tttcttgtac aaagtggttg atatcatcta gagcggccgc aggtacctga ataactaagg     6780

ccgcttccct ttagtgaggg ttaatgcttc gagcagacaa agggttcgat ccctaccggt     6840

tagtaatgag tttaaacggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg     6900

aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg     6960

ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagacccc     7020

attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg     7080

aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagcc taggggcgcg     7140

ccgtttaaac gagggcctat ttcccatgat tccttcatat ttgcatatac gatacaaggc     7200

tgttagagag ataattggaa ttaatttgac tgtaaacaca aagatattag tacaaaatac     7260

gtgacgtaga aagtaataat ttcttgggta gtttgcagtt ttaaaattat gttttaaaat     7320

ggactatcat atgcttaccg taacttgaaa gtatttcgat ttcttggctt tatatatctt     7380

gtggaaagga cgaaacaccg taggcgaccg gctttgagaa gttttagagc tagaaatagc     7440

aagttaaaat aaggctagtc cgttatcaac ttgaaaaagt ggcaccgagt cggtgctttt     7500

tttgtatacg agggcctatt tcccatgatt ccttcatatt tgcatatacg atacaaggct     7560

gttagagaga taattggaat taatttgact gtaaacacaa agatattagt acaaaatacg     7620

tgacgtagaa agtaataatt tcttgggtag tttgcagttt taaaattatg ttttaaaatg     7680

gactatcata tgcttaccgt aacttgaaag tatttcgatt tcttggcttt atatatcttg     7740

tggaaaggac gaaacaccgc tgtggaagtc tccaaacgcg ttttagagct agaaatagca     7800

agttaaaata aggctagtcc gttatcaact tgaaaaagtg gcaccgagtc ggtgcttttt     7860

ttgttaacga gggcctattt cccatgattc cttcatattt gcatatacga tacaaggctg     7920

ttagagagat aattggaatt aatttgactg taaacacaaa gatattagta caaaatacgt     7980

gacgtagaaa gtaataattt cttgggtagt ttgcagtttt aaaattatgt tttaaaatgg     8040

actatcatat gcttaccgta acttgaaagt atttcgattt cttggcttta tatatcttgt     8100

ggaaaggacg aaacaccgtc ttctctctcg gcgctatggt tttagagcta gaaatagcaa     8160

gttaaaataa ggctagtccg ttatcaactt gaaaaagtgg caccgagtcg gtgctttttt     8220

tatttaaata gctagcttaa ttaaagctga atctaagtgg atctgcgatc gctccggtgc     8280

ccgtcagtgg gcagagcgca catcgcccac agtccccgag aagttggggg gaggggtcgg     8340

caattgaacg ggtgcctaga gaaggtggcg cggggtaaac tgggaaagtg atgtcgtgta     8400

ctggctccgc ctttttcccg agggtggggg agaaccgtat ataagtgcag tagtcgccgt     8460

gaacgttctt tttcgcaacg ggtttgccgc cagaacacag ctgaagcttc gaggggctcg     8520

catctctcct tcacgcgccc gccgccctac ctgaggccgc catccacgcc ggttgagtcg     8580

cgttctgccg cctcccgcct gtggtgcctc ctgaactgcg tccgccgtct aggtaagttt     8640

aaagctcagg tcgagaccgg gcctttgtcc ggcgctccct tggagcctac ctagactcag     8700

ccggctctcc acgctttgcc tgaccctgct tgctcaactc tacgtctttg tttcgttttc     8760

tgttctgcgc cgttacagat ccaagctgtg accggcgcct actctagagc cgccatgtct     8820

agactggaca agagcaaagt cataaactct gctctggaat tactcaatgg agtcggtatc     8880

gaaggcctga cgacaaggaa actcgctcaa aagctgggag ttgagcagcc taccctgtac     8940

tggcacgtga agaacaagcg ggccctgctc gatgccctgc caatcgagat gctggacagg     9000

catcataccc actcctgccc cctggaaggc gagtcatggc aagactttct gcggaacaac     9060

gccaagtcat accgctgtgc tctcctctca catcgcgacg gggctaaagt gcatctcggc     9120

acccgcccaa cagagaaaca gtacgaaacc ctggaaaatc agctcgcgtt cctgtgtcag     9180

caaggcttct ccctggagaa cgcactgtac gctctgtccg ccgtgggcca ctttacactg     9240

ggctgcgtat tggaggaaca ggagcatcaa gtagcaaaag aggaaagaga gacacctacc     9300

accgattcta tgcccccact tctgaaacaa gcaattgagc tgttcgaccg gcagggagcc     9360

gaacctgcct tccttttcgg cctggaacta atcatatgtg gcctggagaa acagctaaag     9420

tgcgaaagcg gcgggccgac cgacgccctt gacgattttg acttagacat gctcccagcc     9480

gatgcccttg acgactttga ccttgatatg ctgcctgctg acgctcttga cgattttgac     9540

cttgacatgc tccccgggga gggcagagga agtcttctaa catgcggtga cgtggaggag     9600

aatcccggcc ctgaattcat gaccgagtac aagcccacgg tgcgcctcgc cacccgcgac     9660

gacgtcccca gggccgtacg caccctcgcc gccgcgttcg ccgactaccc cgccacgcgc     9720

cacaccgtcg atccggaccg ccacatcgag cgggtcaccg agctgcaaga actcttcctc     9780

acgcgcgtcg ggctcgacat cggcaaggtg tgggtcgcgg acgacggcgc cgcggtggcg     9840

gtctggacca cgccggagag cgtcgaagcg ggggcggtgt tcgccgagat cggcccgcgc     9900

atggccgagt tgagcggttc ccggctggcc gcgcagcaac agatggaagg cctcctggcg     9960

ccgcaccggc ccaaggagcc cgcgtggttc ctggccaccg tcggcgtctc gcccgaccac    10020

cagggcaagg gtctgggcag cgccgtcgtg ctccccggag tggaggcggc cgagcgcgcc    10080

ggggtgcccg ccttcctgga gacctccgcg ccccgcaacc tccccttcta cgagcggctc    10140

ggcttcaccg tcaccgccga cgtcgaggtg cccgaaggac cgcgcacctg gtgcatgacc    10200

cgcaagcccg gtgcctgagt cgacaatcaa cctctggatt acaaaatttg tgggttaact    10260

tgtttattgc agcttataat ggttacaaat aaagcaatag catcacaaat ttcacaaata    10320

aagcattttt ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc    10380

atgtctggaa ttgactcaaa tgatgtcaat tagtctatca gaagctatct ggtctccctt    10440

ccgggggaca agacatccct gtttaatatt taaacagcag tgttcccaaa ctgggttctt    10500

atatcccttg ctctggtcaa ccaggttgca gggtttcctg tcctcacagg aacgaagtcc    10560

ctaaagaaac agtggcagcc aggtttagcc ccggaattga ctggattcct tttttagggc    10620

ccattggtat ggctttttcc ccgtatcccc ccaggtgtct gcaggctcaa agagcagcga    10680

gaagcgttca gaggaaagcg atcccgtgcc accttccccg tgcccgggct gtccccgcac    10740

gctgccggct cggggatgcg gggggagcgc cggaccggag cggagccccg ggcggctcgc    10800

tgctgccccc tagcggggga gggacgtaat tacatccctg ggggctttgg gggggggctg    10860

tccctgatat ctataacaag aaaatatata tataataagt tatcacgtaa gtagaacatg    10920

aaataacaat ataattatcg tatgagttaa atcttaaaag tcacgtaaaa gataatcatg    10980

cgtcattttg actcacgcgg tcgttatagt tcaaaatcag tgacacttac cgcattgaca    11040

agcacgcctc acgggagctc caagcggcga ctgagatgtc ctaaatgcac agcgacggat    11100

tcgcgctatt tagaaagaga gagcaatatt tcaagaatgc atgcgtcaat tttacgcaga    11160

ctatctttct agggttaa                                                  11178


<210> 124
<211> 10428
<212> DNA
<213> Artificial Sequence


<220> 
<223> PiggyBac-TRE-dCas9-VPR-polyA-sgRNA.lacZ-EF1a-rtTA-T2A-PuroR-polyA

<400> 124
ttaaccctag aaagataatc atattgtgac gtacgttaaa gataatcatg cgtaaaattg       60

acgcatgtgt tttatcggtc tgtatatcga ggtttattta ttaatttgaa tagatattaa      120

gttttattat atttacactt acatactaat aataaattca acaaacaatt tatttatgtt      180

tatttattta ttaaaaaaaa acaaaaactc aaaatttctt ctataaagta acaaaacttt      240

tatgagggac agcccccccc caaagccccc agggatgtaa ttacgtccct cccccgctag      300

ggggcagcag cgagccgccc ggggctccgc tccggtccgg cgctcccccc gcatccccga      360

gccggcagcg tgcggggaca gcccgggcac ggggaaggtg gcacgggatc gctttcctct      420

gaacgcttct cgctgctctt tgagcctgca gacacctggg gggatacggg gaaaaggcct      480

ccacggccac tagttttact ccctatcagt gatagagaac gtatgaagag tttactccct      540

atcagtgata gagaacgtat gcagacttta ctccctatca gtgatagaga acgtataagg      600

agtttactcc ctatcagtga tagagaacgt atgaccagtt tactccctat cagtgataga      660

gaacgtatct acagtttact ccctatcagt gatagagaac gtatatccag tttactccct      720

atcagtgata gagaacgtat aagctttagg cgtgtacggt gggcgcctat aaaagcagag      780

ctcgtttagt gaaccgtcag atcgcctgga gcaattccac aacacttttg tcttatacca      840

actttccgta ccacttccta ccctcgtaaa ggtctagagc tagcgaattc gaatttaaat      900

ctacgtagcc accatggaca agaagtactc cattgggctc gctatcggca caaacagcgt      960

cggctgggcc gtcattacgg acgagtacaa ggtgccgagc aaaaaattca aagttctggg     1020

caataccgat cgccacagca taaagaagaa cctcattggc gccctcctgt tcgactccgg     1080

ggagacggcc gaagccacgc ggctcaaaag aacagcacgg cgcagatata cccgcagaaa     1140

gaatcggatc tgctacctgc aggagatctt tagtaatgag atggctaagg tggatgactc     1200

tttcttccat aggctggagg agtccttttt ggtggaggag gataaaaagc acgagcgcca     1260

cccaatcttt ggcaatatcg tggacgaggt ggcgtaccat gaaaagtacc caaccatata     1320

tcatctgagg aagaagcttg tagacagtac tgataaggct gacttgcggt tgatctatct     1380

cgcgctggcg catatgatca aatttcgggg acacttcctc atcgaggggg acctgaaccc     1440

agacaacagc gatgtcgaca aactctttat ccaactggtt cagacttaca atcagctttt     1500

cgaagagaac ccgatcaacg catccggagt tgacgccaaa gcaatcctga gcgctaggct     1560

gtccaaatcc cggcggctcg aaaacctcat cgcacagctc cctggggaga agaagaacgg     1620

cctgtttggt aatcttatcg ccctgtcact cgggctgacc cccaacttta aatctaactt     1680

cgacctggcc gaagatgcca agcttcaact gagcaaagac acctacgatg atgatctcga     1740

caatctgctg gcccagatcg gcgaccagta cgcagacctt tttttggcgg caaagaacct     1800

gtcagacgcc attctgctga gtgatattct gcgagtgaac acggagatca ccaaagctcc     1860

gctgagcgct agtatgatca agcgctatga tgagcaccac caagacttga ctttgctgaa     1920

ggcccttgtc agacagcaac tgcctgagaa gtacaaggaa attttcttcg atcagtctaa     1980

aaatggctac gccggataca ttgacggcgg agcaagccag gaggaatttt acaaatttat     2040

taagcccatc ttggaaaaaa tggacggcac cgaggagctg ctggtaaagc ttaacagaga     2100

agatctgttg cgcaaacagc gcactttcga caatggaagc atcccccacc agattcacct     2160

gggcgaactg cacgctatcc tcaggcggca agaggatttc tacccctttt tgaaagataa     2220

cagggaaaag attgagaaaa tcctcacatt tcggataccc tactatgtag gccccctcgc     2280

ccggggaaat tccagattcg cgtggatgac tcgcaaatca gaagagacca tcactccctg     2340

gaacttcgag gaagtcgtgg ataagggggc ctctgcccag tccttcatcg aaaggatgac     2400

taactttgat aaaaatctgc ctaacgaaaa ggtgcttcct aaacactctc tgctgtacga     2460

gtacttcaca gtttataacg agctcaccaa ggtcaaatac gtcacagaag ggatgagaaa     2520

gccagcattc ctgtctggag agcagaagaa agctatcgtg gacctcctct tcaagacgaa     2580

ccggaaagtt accgtgaaac agctcaaaga agactatttc aaaaagattg aatgtttcga     2640

ctctgttgaa atcagcggag tggaggatcg cttcaacgca tccctgggaa cgtatcacga     2700

tctcctgaaa atcattaaag acaaggactt cctggacaat gaggagaacg aggacattct     2760

tgaggacatt gtcctcaccc ttacgttgtt tgaagatagg gagatgattg aagaacgctt     2820

gaaaacttac gctcatctct tcgacgacaa agtcatgaaa cagctcaaga ggcgccgata     2880

tacaggatgg gggcggctgt caagaaaact gatcaatggg atccgagaca agcagagtgg     2940

aaagacaatc ctggattttc ttaagtccga tggatttgcc aaccggaact tcatgcagtt     3000

gatccatgat gactctctca cctttaagga ggacatccag aaagcacaag tttctggcca     3060

gggggacagt cttcacgagc acatcgctaa tcttgcaggt agcccagcta tcaaaaaggg     3120

aatactgcag accgttaagg tcgtggatga actcgtcaaa gtaatgggaa ggcataagcc     3180

cgagaatatc gttatcgaga tggcccgaga gaaccaaact acccagaagg gacagaagaa     3240

cagtagggaa aggatgaaga ggattgaaga gggtataaaa gaactggggt cccaaatcct     3300

taaggaacac ccagttgaaa acacccagct tcagaatgag aagctctacc tgtactacct     3360

gcagaacggc agggacatgt acgtggatca ggaactggac atcaatcggc tctccgacta     3420

cgacgtggct gctatcgtgc cccagtcttt tctcaaagat gattctattg ataataaagt     3480

gttgacaaga tccgataaag ctagagggaa gagtgataac gtcccctcag aagaagttgt     3540

caagaaaatg aaaaattatt ggcggcagct gctgaacgcc aaactgatca cacaacggaa     3600

gttcgataat ctgactaagg ctgaacgagg tggcctgtct gagttggata aagccggctt     3660

catcaaaagg cagcttgttg agacacgcca gatcaccaag cacgtggccc aaattctcga     3720

ttcacgcatg aacaccaagt acgatgaaaa tgacaaactg attcgagagg tgaaagttat     3780

tactctgaag tctaagctgg tctcagattt cagaaaggac tttcagtttt ataaggtgag     3840

agagatcaac aattaccacc atgcgcatga tgcctacctg aatgcagtgg taggcactgc     3900

acttatcaaa aaatatccca agcttgaatc tgaatttgtt tacggagact ataaagtgta     3960

cgatgttagg aaaatgatcg caaagtctga gcaggaaata ggcaaggcca ccgctaagta     4020

cttcttttac agcaatatta tgaatttttt caagaccgag attacactgg ccaatggaga     4080

gattcggaag cgaccactta tcgaaacaaa cggagaaaca ggagaaatcg tgtgggacaa     4140

gggtagggat ttcgcgacag tccggaaggt cctgtccatg ccgcaggtga acatcgttaa     4200

aaagaccgaa gtacagaccg gaggcttctc caaggaaagt atcctcccga aaaggaacag     4260

cgacaagctg atcgcacgca aaaaagattg ggaccccaag aaatacggcg gattcgattc     4320

tcctacagtc gcttacagtg tactggttgt ggccaaagtg gagaaaggga agtctaaaaa     4380

actcaaaagc gtcaaggaac tgctgggcat cacaatcatg gagcgatcaa gcttcgaaaa     4440

aaaccccatc gactttctcg aggcgaaagg atataaagag gtcaaaaaag acctcatcat     4500

taagcttccc aagtactctc tctttgagct tgaaaacggc cggaaacgaa tgctcgctag     4560

tgcgggcgag ctgcagaaag gtaacgagct ggcactgccc tctaaatacg ttaatttctt     4620

gtatctggcc agccactatg aaaagctcaa agggtctccc gaagataatg agcagaagca     4680

gctgttcgtg gaacaacaca aacactacct tgatgagatc atcgagcaaa taagcgaatt     4740

ctccaaaaga gtgatcctcg ccgacgctaa cctcgataag gtgctttctg cttacaataa     4800

gcacagggat aagcccatca gggagcaggc agaaaacatt atccacttgt ttactctgac     4860

caacttgggc gcgcctgcag ccttcaagta cttcgacacc accatagaca gaaagcggta     4920

cacctctaca aaggaggtcc tggacgccac actgattcat cagtcaatta cggggctcta     4980

tgaaacaaga atcgacctct ctcagctcgg tggagacagc agggctgacc ccaagaagaa     5040

gaggaaggtg tcgccaggga tccgtcgact tgacgcgttg atatcaacaa gtttgtacaa     5100

aaaagcaggc tacaaagagg ccagcggttc cggacgggct gacgcattgg acgattttga     5160

tctggatatg ctgggaagtg acgccctcga tgattttgac cttgacatgc ttggttcgga     5220

tgcccttgat gactttgacc tcgacatgct cggcagtgac gcccttgatg atttcgacct     5280

ggacatgctg attaactcta gaagttccgg atctccgaaa aagaaacgca aagttggtag     5340

ccagtacctg cccgacaccg acgaccggca ccggatcgag gaaaagcgga agcggaccta     5400

cgagacattc aagagcatca tgaagaagtc ccccttcagc ggccccaccg accctagacc     5460

tccacctaga agaatcgccg tgcccagcag atccagcgcc agcgtgccaa aacctgcccc     5520

ccagccttac cccttcacca gcagcctgag caccatcaac tacgacgagt tccctaccat     5580

ggtgttcccc agcggccaga tctctcaggc ctctgctctg gctccagccc ctcctcaggt     5640

gctgcctcag gctcctgctc ctgcaccagc tccagccatg gtgtctgcac tggctcaggc     5700

accagcaccc gtgcctgtgc tggctcctgg acctccacag gctgtggctc caccagcccc     5760

taaacctaca caggccggcg agggcacact gtctgaagct ctgctgcagc tgcagttcga     5820

cgacgaggat ctgggagccc tgctgggaaa cagcaccgat cctgccgtgt tcaccgacct     5880

ggccagcgtg gacaacagcg agttccagca gctgctgaac cagggcatcc ctgtggcccc     5940

tcacaccacc gagcccatgc tgatggaata ccccgaggcc atcacccggc tcgtgacagg     6000

cgctcagagg cctcctgatc cagctcctgc ccctctggga gcaccaggcc tgcctaatgg     6060

actgctgtct ggcgacgagg acttcagctc tatcgccgat atggatttct cagccttgct     6120

gggctctggc agcggcagcc gggattccag ggaagggatg tttttgccga agcctgaggc     6180

cggctccgct attagtgacg tgtttgaggg ccgcgaggtg tgccagccaa aacgaatccg     6240

gccatttcat cctccaggaa gtccatgggc caaccgccca ctccccgcca gcctcgcacc     6300

aacaccaacc ggtccagtac atgagccagt cgggtcactg accccggcac cagtccctca     6360

gccactggat ccagcgcccg cagtgactcc cgaggccagt cacctgttgg aggatcccga     6420

tgaagagacg agccaggctg tcaaagccct tcgggagatg gccgatactg tgattcccca     6480

gaaggaagag gctgcaatct gtggccaaat ggacctttcc catccgcccc caaggggcca     6540

tctggatgag ctgacaacca cacttgagtc catgaccgag gatctgaacc tggactcacc     6600

cctgaccccg gaattgaacg agattctgga taccttcctg aacgacgagt gcctcttgca     6660

tgccatgcat atcagcacag gactgtccat cttcgacaca tctctgtttt gaaacccagc     6720

tttcttgtac aaagtggttg atatcatcta gagcggccgc aggtacctga ataactaagg     6780

ccgcttccct ttagtgaggg ttaatgcttc gagcagacaa agggttcgat ccctaccggt     6840

tagtaatgag tttaaacggg ggaggctaac tgaaacacgg aaggagacaa taccggaagg     6900

aacccgcgct atgacggcaa taaaaagaca gaataaaacg cacgggtgtt gggtcgtttg     6960

ttcataaacg cggggttcgg tcccagggct ggcactctgt cgatacccca ccgagacccc     7020

attggggcca atacgcccgc gtttcttcct tttccccacc ccacccccca agttcgggtg     7080

aaggcccagg gctcgcagcc aacgtcgggg cggcaggccc tgccatagcc tagggagggc     7140

ctatttccca tgattccttc atatttgcat atacgataca aggctgttag agagataatt     7200

agaattaatt tgactgtaaa cacaaagata ttagtacaaa atacgtgacg tagaaagtaa     7260

taatttcttg ggtagtttgc agttttaaaa ttatgtttta aaatggacta tcatatgctt     7320

accgtaactt gaaagtattt cgatttcttg gctttatata tcttgtggaa aggacgaaac     7380

accgtctgac cgatgatccg cgcgttttag agctagaaat agcaagttaa aataaggcta     7440

gtccgttatc aacttgaaaa agtggcaccg agtcggtgct ttttttttaa ttaaagctga     7500

atctaagtgg atctgcgatc gctccggtgc ccgtcagtgg gcagagcgca catcgcccac     7560

agtccccgag aagttggggg gaggggtcgg caattgaacg ggtgcctaga gaaggtggcg     7620

cggggtaaac tgggaaagtg atgtcgtgta ctggctccgc ctttttcccg agggtggggg     7680

agaaccgtat ataagtgcag tagtcgccgt gaacgttctt tttcgcaacg ggtttgccgc     7740

cagaacacag ctgaagcttc gaggggctcg catctctcct tcacgcgccc gccgccctac     7800

ctgaggccgc catccacgcc ggttgagtcg cgttctgccg cctcccgcct gtggtgcctc     7860

ctgaactgcg tccgccgtct aggtaagttt aaagctcagg tcgagaccgg gcctttgtcc     7920

ggcgctccct tggagcctac ctagactcag ccggctctcc acgctttgcc tgaccctgct     7980

tgctcaactc tacgtctttg tttcgttttc tgttctgcgc cgttacagat ccaagctgtg     8040

accggcgcct actctagagc cgccatgtct agactggaca agagcaaagt cataaactct     8100

gctctggaat tactcaatgg agtcggtatc gaaggcctga cgacaaggaa actcgctcaa     8160

aagctgggag ttgagcagcc taccctgtac tggcacgtga agaacaagcg ggccctgctc     8220

gatgccctgc caatcgagat gctggacagg catcataccc actcctgccc cctggaaggc     8280

gagtcatggc aagactttct gcggaacaac gccaagtcat accgctgtgc tctcctctca     8340

catcgcgacg gggctaaagt gcatctcggc acccgcccaa cagagaaaca gtacgaaacc     8400

ctggaaaatc agctcgcgtt cctgtgtcag caaggcttct ccctggagaa cgcactgtac     8460

gctctgtccg ccgtgggcca ctttacactg ggctgcgtat tggaggaaca ggagcatcaa     8520

gtagcaaaag aggaaagaga gacacctacc accgattcta tgcccccact tctgaaacaa     8580

gcaattgagc tgttcgaccg gcagggagcc gaacctgcct tccttttcgg cctggaacta     8640

atcatatgtg gcctggagaa acagctaaag tgcgaaagcg gcgggccgac cgacgccctt     8700

gacgattttg acttagacat gctcccagcc gatgcccttg acgactttga ccttgatatg     8760

ctgcctgctg acgctcttga cgattttgac cttgacatgc tccccgggga gggcagagga     8820

agtcttctaa catgcggtga cgtggaggag aatcccggcc ctgaattcat gaccgagtac     8880

aagcccacgg tgcgcctcgc cacccgcgac gacgtcccca gggccgtacg caccctcgcc     8940

gccgcgttcg ccgactaccc cgccacgcgc cacaccgtcg atccggaccg ccacatcgag     9000

cgggtcaccg agctgcaaga actcttcctc acgcgcgtcg ggctcgacat cggcaaggtg     9060

tgggtcgcgg acgacggcgc cgcggtggcg gtctggacca cgccggagag cgtcgaagcg     9120

ggggcggtgt tcgccgagat cggcccgcgc atggccgagt tgagcggttc ccggctggcc     9180

gcgcagcaac agatggaagg cctcctggcg ccgcaccggc ccaaggagcc cgcgtggttc     9240

ctggccaccg tcggcgtctc gcccgaccac cagggcaagg gtctgggcag cgccgtcgtg     9300

ctccccggag tggaggcggc cgagcgcgcc ggggtgcccg ccttcctgga gacctccgcg     9360

ccccgcaacc tccccttcta cgagcggctc ggcttcaccg tcaccgccga cgtcgaggtg     9420

cccgaaggac cgcgcacctg gtgcatgacc cgcaagcccg gtgcctgagt cgacaatcaa     9480

cctctggatt acaaaatttg tgggttaact tgtttattgc agcttataat ggttacaaat     9540

aaagcaatag catcacaaat ttcacaaata aagcattttt ttcactgcat tctagttgtg     9600

gtttgtccaa actcatcaat gtatcttatc atgtctggaa ttgactcaaa tgatgtcaat     9660

tagtctatca gaagctatct ggtctccctt ccgggggaca agacatccct gtttaatatt     9720

taaacagcag tgttcccaaa ctgggttctt atatcccttg ctctggtcaa ccaggttgca     9780

gggtttcctg tcctcacagg aacgaagtcc ctaaagaaac agtggcagcc aggtttagcc     9840

ccggaattga ctggattcct tttttagggc ccattggtat ggctttttcc ccgtatcccc     9900

ccaggtgtct gcaggctcaa agagcagcga gaagcgttca gaggaaagcg atcccgtgcc     9960

accttccccg tgcccgggct gtccccgcac gctgccggct cggggatgcg gggggagcgc    10020

cggaccggag cggagccccg ggcggctcgc tgctgccccc tagcggggga gggacgtaat    10080

tacatccctg ggggctttgg gggggggctg tccctgatat ctataacaag aaaatatata    10140

tataataagt tatcacgtaa gtagaacatg aaataacaat ataattatcg tatgagttaa    10200

atcttaaaag tcacgtaaaa gataatcatg cgtcattttg actcacgcgg tcgttatagt    10260

tcaaaatcag tgacacttac cgcattgaca agcacgcctc acgggagctc caagcggcga    10320

ctgagatgtc ctaaatgcac agcgacggat tcgcgctatt tagaaagaga gagcaatatt    10380

tcaagaatgc atgcgtcaat tttacgcaga ctatctttct agggttaa                 10428


<210> 125
<211> 23
<212> DNA
<213> Artificial Sequence


<220> 
<223> lacZ sgRNA

<400> 125
gtctgaccga tgatccgcgc tgg                                            23


<210> 126
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1mw_1_short

<400> 126
ggggccttta aggtaagg                                                  18


<210> 127
<211> 18
<212> DNA
<213> Artificial Sequence


<220> 
<223> sgOpn1mw_2_short

<400> 127
gccacccctg tggattgg                                                  18


