                         SEQUENCE LISTING

<110>  Macquarie University
 
<120>  Treatment of Tauopathies

<130>  P111578.PCT

<150>  AU2019903530
<151>  2019-09-23

<160>  109   

<170>  PatentIn version 3.5

<210>  1
<211>  441
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  2
<211>  2280
<212>  RNA
<213>  Homo sapiens

<400>  2
caggcucugc ggggugggca gcucccgggc cugccaugag cucuccgccg cccgcccgca       60

guggcuuuua ccgccaggag gugaccaaga cggccuggga ggugcgcgcc guguaccggg      120

accugcagcc cgugggcucg ggcgccuacg gcgcggugug cucggccgug gacggccgca      180

ccggcgcuaa gguggccauc aagaagcugu aucggcccuu ccaguccgag cuguucgcca      240

agcgcgccua ccgcgagcug cgccugcuca agcacaugcg ccacgagaac gugaucgggc      300

ugcuggacgu auucacuccu gaugagaccc uggaugacuu cauggacuuu uaccugguga      360

ugccguucau gggcaccgac cugggcaagc ucaugaaaca ugagaagcua ggcgaggacc      420

ggauccaguu ccucguguac cagaugcuga aggggcugag ggaccugaag cccggcaacc      480

uggcugugaa cgaagacugu gagcugaaga uccuggacuu cggccuggcc aggcaggcag      540

acagugagau gacuggguac guggugaccc ggugguaccg ggcucccgag gucaucuuga      600

auuggaugcg cuacacgcag acgguggaca ucugguccgu gggcugcauc auggcggaga      660

ugaucacagg caagacgcug uucaagggca gcgaccaccu ggaccagcug aaggagauca      720

ugaaggugac ggggacgccu ccggcugagu uugugcagcg gcugcagagc gaugaggcca      780

agaacuacau gaagggccuc cccgaauugg agaagaagga uuuugccucu auccugacca      840

augcaagccc ucuggcugug aaccuccugg agaagaugcu ggugcuggac gcggagcagc      900

gggugacggc aggcgaggcg cuggcccauc ccuacuucga gucccugcac gacacggaag      960

augagcccca gguccagaag uaugaugacu ccuuugacga cguugaccgc acacuggaug     1020

aauggaagcg uguuacuuac aaagaggugc ucagcuucaa gccuccccgg cagcuggggg     1080

ccagggucuc caaggagacg ccucugugaa gaucucuggg cuccggggug gcagugagga     1140

caggcucugc ggggugggca gcucccgggc cugccaugag cucuccgccg cccgcccgca     1200

guggcuuuua ccgccaggag gugaccaaga cggccuggga ggugcgcgcc guguaccggg     1260

accugcagcc cgugggcucg ggcgccuacg gcgcggugug cucggccgug gacggccgca     1320

ccggcgcuaa gguggccauc aagaagcugu aucggcccuu ccaguccgag cuguucgcca     1380

agcgcgccua ccgcgagcug cgccugcuca agcacaugcg ccacgagaac gugaucgggc     1440

ugcuggacgu auucacuccu gaugagaccc uggaugacuu cauggacuuu uaccugguga     1500

ugccguucau gggcaccgac cugggcaagc ucaugaaaca ugagaagcua ggcgaggacc     1560

ggauccaguu ccucguguac cagaugcuga aggggcugag ggaccugaag cccggcaacc     1620

uggcugugaa cgaagacugu gagcugaaga uccuggacuu cggccuggcc aggcaggcag     1680

acagugagau gacuggguac guggugaccc ggugguaccg ggcucccgag gucaucuuga     1740

auuggaugcg cuacacgcag acgguggaca ucugguccgu gggcugcauc auggcggaga     1800

ugaucacagg caagacgcug uucaagggca gcgaccaccu ggaccagcug aaggagauca     1860

ugaaggugac ggggacgccu ccggcugagu uugugcagcg gcugcagagc gaugaggcca     1920

agaacuacau gaagggccuc cccgaauugg agaagaagga uuuugccucu auccugacca     1980

augcaagccc ucuggcugug aaccuccugg agaagaugcu ggugcuggac gcggagcagc     2040

gggugacggc aggcgaggcg cuggcccauc ccuacuucga gucccugcac gacacggaag     2100

augagcccca gguccagaag uaugaugacu ccuuugacga cguugaccgc acacuggaug     2160

aauggaagcg uguuacuuac aaagaggugc ucagcuucaa gccuccccgg cagcuggggg     2220

ccagggucuc caaggagacg ccucugugaa gaucucuggg cuccggggug gcagugagga     2280


<210>  3
<211>  357
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Met Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Asp Leu 
    130                 135                 140                 


Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Arg Gln Ala Asp Ser Glu Met Thr Gly Tyr Val 
                165                 170                 175     


Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg 
            180                 185                 190         


Tyr Thr Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu 
        195                 200                 205             


Met Ile Thr Gly Lys Thr Leu Phe Lys Gly Ser Asp His Leu Asp Gln 
    210                 215                 220                 


Leu Lys Glu Ile Met Lys Val Thr Gly Thr Pro Pro Ala Glu Phe Val 
225                 230                 235                 240 


Gln Arg Leu Gln Ser Asp Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro 
                245                 250                 255     


Glu Leu Glu Lys Lys Asp Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro 
            260                 265                 270         


Leu Ala Val Asn Leu Leu Glu Lys Met Leu Val Leu Asp Ala Glu Gln 
        275                 280                 285             


Arg Val Thr Ala Gly Glu Ala Leu Ala His Pro Tyr Phe Glu Ser Leu 
    290                 295                 300                 


His Asp Thr Glu Asp Glu Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe 
305                 310                 315                 320 


Asp Asp Val Asp Arg Thr Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys 
                325                 330                 335     


Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser 
            340                 345                 350         


Lys Glu Thr Pro Leu 
        355         


<210>  4
<211>  357
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  D179A mutant of human P38gamma

<400>  4

Met Ser Ser Pro Pro Pro Ala Arg Ser Gly Phe Tyr Arg Gln Glu Val 
1               5                   10                  15      


Thr Lys Thr Ala Trp Glu Val Arg Ala Val Tyr Arg Asp Leu Gln Pro 
            20                  25                  30          


Val Gly Ser Gly Ala Tyr Gly Ala Val Cys Ser Ala Val Asp Gly Arg 
        35                  40                  45              


Thr Gly Ala Lys Val Ala Ile Lys Lys Leu Tyr Arg Pro Phe Gln Ser 
    50                  55                  60                  


Glu Leu Phe Ala Lys Arg Ala Tyr Arg Glu Leu Arg Leu Leu Lys His 
65                  70                  75                  80  


Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
                85                  90                  95      


Glu Thr Leu Asp Asp Phe Met Asp Phe Tyr Leu Val Met Pro Phe Met 
            100                 105                 110         


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        115                 120                 125             


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Asp Leu 
    130                 135                 140                 


Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu 
145                 150                 155                 160 


Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val 
                165                 170                 175     


Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg 
            180                 185                 190         


Tyr Thr Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu 
        195                 200                 205             


Met Ile Thr Gly Lys Thr Leu Phe Lys Gly Ser Asp His Leu Asp Gln 
    210                 215                 220                 


Leu Lys Glu Ile Met Lys Val Thr Gly Thr Pro Pro Ala Glu Phe Val 
225                 230                 235                 240 


Gln Arg Leu Gln Ser Asp Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro 
                245                 250                 255     


Glu Leu Glu Lys Lys Asp Phe Ala Ser Ile Leu Thr Asn Ala Ser Pro 
            260                 265                 270         


Leu Ala Val Asn Leu Leu Glu Lys Met Leu Val Leu Asp Ala Glu Gln 
        275                 280                 285             


Arg Val Thr Ala Gly Glu Ala Leu Ala His Pro Tyr Phe Glu Ser Leu 
    290                 295                 300                 


His Asp Thr Glu Asp Glu Pro Gln Val Gln Lys Tyr Asp Asp Ser Phe 
305                 310                 315                 320 


Asp Asp Val Asp Arg Thr Leu Asp Glu Trp Lys Arg Val Thr Tyr Lys 
                325                 330                 335     


Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser 
            340                 345                 350         


Lys Glu Thr Pro Leu 
        355         


<210>  5
<211>  441
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant human tau T205E

<400>  5

Met Ala Glu Pro Arg Gln Glu Phe Glu Val Met Glu Asp His Ala Gly 
1               5                   10                  15      


Thr Tyr Gly Leu Gly Asp Arg Lys Asp Gln Gly Gly Tyr Thr Met His 
            20                  25                  30          


Gln Asp Gln Glu Gly Asp Thr Asp Ala Gly Leu Lys Glu Ser Pro Leu 
        35                  40                  45              


Gln Thr Pro Thr Glu Asp Gly Ser Glu Glu Pro Gly Ser Glu Thr Ser 
    50                  55                  60                  


Asp Ala Lys Ser Thr Pro Thr Ala Glu Asp Val Thr Ala Pro Leu Val 
65                  70                  75                  80  


Asp Glu Gly Ala Pro Gly Lys Gln Ala Ala Ala Gln Pro His Thr Glu 
                85                  90                  95      


Ile Pro Glu Gly Thr Thr Ala Glu Glu Ala Gly Ile Gly Asp Thr Pro 
            100                 105                 110         


Ser Leu Glu Asp Glu Ala Ala Gly His Val Thr Gln Ala Arg Met Val 
        115                 120                 125             


Ser Lys Ser Lys Asp Gly Thr Gly Ser Asp Asp Lys Lys Ala Lys Gly 
    130                 135                 140                 


Ala Asp Gly Lys Thr Lys Ile Ala Thr Pro Arg Gly Ala Ala Pro Pro 
145                 150                 155                 160 


Gly Gln Lys Gly Gln Ala Asn Ala Thr Arg Ile Pro Ala Lys Thr Pro 
                165                 170                 175     


Pro Ala Pro Lys Thr Pro Pro Ser Ser Gly Glu Pro Pro Lys Ser Gly 
            180                 185                 190         


Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Glu Pro Gly Ser 
        195                 200                 205             


Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr Arg Glu Pro Lys 
    210                 215                 220                 


Lys Val Ala Val Val Arg Thr Pro Pro Lys Ser Pro Ser Ser Ala Lys 
225                 230                 235                 240 


Ser Arg Leu Gln Thr Ala Pro Val Pro Met Pro Asp Leu Lys Asn Val 
                245                 250                 255     


Lys Ser Lys Ile Gly Ser Thr Glu Asn Leu Lys His Gln Pro Gly Gly 
            260                 265                 270         


Gly Lys Val Gln Ile Ile Asn Lys Lys Leu Asp Leu Ser Asn Val Gln 
        275                 280                 285             


Ser Lys Cys Gly Ser Lys Asp Asn Ile Lys His Val Pro Gly Gly Gly 
    290                 295                 300                 


Ser Val Gln Ile Val Tyr Lys Pro Val Asp Leu Ser Lys Val Thr Ser 
305                 310                 315                 320 


Lys Cys Gly Ser Leu Gly Asn Ile His His Lys Pro Gly Gly Gly Gln 
                325                 330                 335     


Val Glu Val Lys Ser Glu Lys Leu Asp Phe Lys Asp Arg Val Gln Ser 
            340                 345                 350         


Lys Ile Gly Ser Leu Asp Asn Ile Thr His Val Pro Gly Gly Gly Asn 
        355                 360                 365             


Lys Lys Ile Glu Thr His Lys Leu Thr Phe Arg Glu Asn Ala Lys Ala 
    370                 375                 380                 


Lys Thr Asp His Gly Ala Glu Ile Val Tyr Lys Ser Pro Val Val Ser 
385                 390                 395                 400 


Gly Asp Thr Ser Pro Arg His Leu Ser Asn Val Ser Ser Thr Gly Ser 
                405                 410                 415     


Ile Asp Met Val Asp Ser Pro Gln Leu Ala Thr Leu Ala Asp Glu Val 
            420                 425                 430         


Ser Ala Ser Leu Ala Lys Gln Gly Leu 
        435                 440     


<210>  6
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Donor sequence for mutating human tau

<400>  6
tctggtgaac ctccaaaatc aggggatcgc agcggctaca gcagccccgg ctccccaggc       60

gagcccggca gccgctcccg caccccgtcc cttccaaccc cacccacccg ggagcccaag      120


<210>  7
<211>  14
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Ser Pro Gly Ser Pro Gly Thr Pro Gly Ser Arg Ser Arg 
1               5                   10                  


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of mutated tau


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D or E

<400>  8

Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg 
1               5                   10                  


<210>  9
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Portion of p38g

<400>  9

Glu Thr Pro Leu 
1               


<210>  10
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  10

Lys Glu Thr Pro Leu 
1               5   


<210>  11
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  11

Ser Lys Glu Thr Pro Leu 
1               5       


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  12

Val Ser Lys Glu Thr Pro Leu 
1               5           


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  13

Arg Val Ser Lys Glu Thr Pro Leu 
1               5               


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ARVSKETPL

<400>  14

Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  15

Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10  


<210>  16
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p36gamma

<400>  16

Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10      


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  17

Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10          


<210>  18
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  18

Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10              


<210>  19
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion p38gamma

<400>  19

Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10                  


<210>  20
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  20

Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10                  15  


<210>  21
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion p38gamma

<400>  21

Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
1               5                   10                  15      


<210>  22
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  22

Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr Pro 
1               5                   10                  15      


Leu 
    


<210>  23
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  23

Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu Thr 
1               5                   10                  15      


Pro Leu 
        


<210>  24
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  24

Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys Glu 
1               5                   10                  15      


Thr Pro Leu 
            


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  25

Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser Lys 
1               5                   10                  15      


Glu Thr Pro Leu 
            20  


<210>  26
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  26

Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Ser 
1               5                   10                  15      


Lys Glu Thr Pro Leu 
            20      


<210>  27
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  27

Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val 
1               5                   10                  15      


Ser Lys Glu Thr Pro Leu 
            20          


<210>  28
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  28

Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg 
1               5                   10                  15      


Val Ser Lys Glu Thr Pro Leu 
            20              


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  29

Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala 
1               5                   10                  15      


Arg Val Ser Lys Glu Thr Pro Leu 
            20                  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  30

Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Ser Lys Glu Thr Pro Leu 
            20                  25  


<210>  31
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  31

Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu 
1               5                   10                  15      


Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
            20                  25      


<210>  32
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  32

Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln 
1               5                   10                  15      


Leu Gly Ala Arg Val Ser Lys Glu Thr Pro Leu 
            20                  25          


<210>  33
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  33

Glu Thr Ala Leu 
1               


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  34

Lys Glu Thr Ala Leu 
1               5   


<210>  35
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  35

Pro Lys Glu Thr Ala Leu 
1               5       


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  36

Val Pro Lys Glu Thr Ala Leu 
1               5           


<210>  37
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  37

Arg Val Pro Lys Glu Thr Ala Leu 
1               5               


<210>  38
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  38

Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  39

Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10  


<210>  40
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  40

Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10      


<210>  41
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  41

Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10          


<210>  42
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  42

Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10              


<210>  43
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  43

Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10                  


<210>  44
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  44

Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10                  15  


<210>  45
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  45

Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
1               5                   10                  15      


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  46

Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr Ala 
1               5                   10                  15      


Leu 
    


<210>  47
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  47

Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu Thr 
1               5                   10                  15      


Ala Leu 
        


<210>  48
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  48

Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys Glu 
1               5                   10                  15      


Thr Ala Leu 
            


<210>  49
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  49

Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro Lys 
1               5                   10                  15      


Glu Thr Ala Leu 
            20  


<210>  50
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  50

Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val Pro 
1               5                   10                  15      


Lys Glu Thr Ala Leu 
            20      


<210>  51
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  51

Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg Val 
1               5                   10                  15      


Pro Lys Glu Thr Ala Leu 
            20          


<210>  52
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  52

Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala Arg 
1               5                   10                  15      


Val Pro Lys Glu Thr Ala Leu 
            20              


<210>  53
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38 gamma

<400>  53

Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly Ala 
1               5                   10                  15      


Arg Val Pro Lys Glu Thr Ala Leu 
            20                  


<210>  54
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  54

Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu Gly 
1               5                   10                  15      


Ala Arg Val Pro Lys Glu Thr Ala Leu 
            20                  25  


<210>  55
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  55

Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln Leu 
1               5                   10                  15      


Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
            20                  25      


<210>  56
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of p38gamma

<400>  56

Lys Arg Val Thr Tyr Lys Glu Val Leu Ser Phe Lys Pro Pro Arg Gln 
1               5                   10                  15      


Leu Gly Ala Arg Val Pro Lys Glu Thr Ala Leu 
            20                  25          


<210>  57
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  57

Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr 
1               5                   10      


<210>  58
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  58

Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val 
1               5                   10              


<210>  59
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  59

Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val 
1               5                   10                  15      


Val Thr Arg Trp 
            20  


<210>  60
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  60

Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
1               5                   10                  15      


Gln Ala Ala Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            20                  25                  30          


Ala Pro Glu Val Ile Leu Asn Trp 
        35                  40  


<210>  61
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  61

His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu 
1               5                   10                  15      


Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser Glu Met 
            20                  25                  30          


Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu 
        35                  40                  45              


Asn Trp Met Arg Tyr Thr Gln Thr Val Asp Ile Trp 
    50                  55                  60  


<210>  62
<211>  80
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutively active mutant of p38gamma

<400>  62

Leu Arg Tyr Ile His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro 
1               5                   10                  15      


Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe 
            20                  25                  30          


Gly Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val Val Thr 
        35                  40                  45              


Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr 
    50                  55                  60                  


Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile 
65                  70                  75                  80  


<210>  63
<211>  100
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  63

Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile His Ala 
1               5                   10                  15      


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn 
            20                  25                  30          


Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala 
        35                  40                  45              


Ala Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro 
    50                  55                  60                  


Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp Ile Trp 
65                  70                  75                  80  


Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr Leu Phe 
                85                  90                  95      


Lys Gly Ser Asp 
            100 


<210>  64
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  64

Lys His Glu Lys Leu Gly Glu Asp Arg Ile Gln Phe Leu Val Tyr Gln 
1               5                   10                  15      


Met Leu Lys Gly Leu Arg Tyr Ile His Ala Ala Gly Ile Ile His Arg 
            20                  25                  30          


Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys 
        35                  40                  45              


Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly 
    50                  55                  60                  


Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp 
65                  70                  75                  80  


Met Arg Tyr Thr Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met 
                85                  90                  95      


Ala Glu Met Ile Thr Gly Lys Thr Leu Phe Lys Gly Ser Asp His Leu 
            100                 105                 110         


Asp Gln Leu Lys Glu Ile Met Lys 
        115                 120 


<210>  65
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  65

Phe Met Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly 
1               5                   10                  15      


Glu Asp Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg 
            20                  25                  30          


Tyr Ile His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn 
        35                  40                  45              


Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu 
    50                  55                  60                  


Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp 
65                  70                  75                  80  


Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr 
                85                  90                  95      


Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly 
            100                 105                 110         


Lys Thr Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile 
        115                 120                 125             


Met Lys Val Thr Gly Thr Pro Pro Ala Glu Phe Val 
    130                 135                 140 


<210>  66
<211>  160
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  66

Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met Gly Thr Asp Leu 
1               5                   10                  15      


Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp Arg Ile Gln Phe 
            20                  25                  30          


Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile His Ala Ala Gly 
        35                  40                  45              


Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala Val Asn Glu Asp 
    50                  55                  60                  


Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser 
65                  70                  75                  80  


Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg Ala Pro Glu Val 
                85                  90                  95      


Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp Ile Trp Ser Val 
            100                 105                 110         


Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr Leu Phe Lys Gly 
        115                 120                 125             


Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys Val Thr Gly Thr 
    130                 135                 140                 


Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp Glu Ala Lys Asn 
145                 150                 155                 160 


<210>  67
<211>  180
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  67

Asp Val Phe Thr Pro Asp Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr 
1               5                   10                  15      


Leu Val Met Pro Phe Met Gly Thr Asp Leu Gly Lys Leu Met Lys His 
            20                  25                  30          


Glu Lys Leu Gly Glu Asp Arg Ile Gln Phe Leu Val Tyr Gln Met Leu 
        35                  40                  45              


Lys Gly Leu Arg Tyr Ile His Ala Ala Gly Ile Ile His Arg Asp Leu 
    50                  55                  60                  


Lys Pro Gly Asn Leu Ala Val Asn Glu Asp Cys Glu Leu Lys Ile Leu 
65                  70                  75                  80  


Asp Phe Gly Leu Ala Arg Gln Ala Ala Ser Glu Met Thr Gly Tyr Val 
                85                  90                  95      


Val Thr Arg Trp Tyr Arg Ala Pro Glu Val Ile Leu Asn Trp Met Arg 
            100                 105                 110         


Tyr Thr Gln Thr Val Asp Ile Trp Ser Val Gly Cys Ile Met Ala Glu 
        115                 120                 125             


Met Ile Thr Gly Lys Thr Leu Phe Lys Gly Ser Asp His Leu Asp Gln 
    130                 135                 140                 


Leu Lys Glu Ile Met Lys Val Thr Gly Thr Pro Pro Ala Glu Phe Val 
145                 150                 155                 160 


Gln Arg Leu Gln Ser Asp Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro 
                165                 170                 175     


Glu Leu Glu Lys 
            180 


<210>  68
<211>  200
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of constitutive mutant of p38gamma

<400>  68

Met Arg His Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Asp 
1               5                   10                  15      


Glu Thr Leu Asp Asp Phe Thr Asp Phe Tyr Leu Val Met Pro Phe Met 
            20                  25                  30          


Gly Thr Asp Leu Gly Lys Leu Met Lys His Glu Lys Leu Gly Glu Asp 
        35                  40                  45              


Arg Ile Gln Phe Leu Val Tyr Gln Met Leu Lys Gly Leu Arg Tyr Ile 
    50                  55                  60                  


His Ala Ala Gly Ile Ile His Arg Asp Leu Lys Pro Gly Asn Leu Ala 
65                  70                  75                  80  


Val Asn Glu Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg 
                85                  90                  95      


Gln Ala Ala Ser Glu Met Thr Gly Tyr Val Val Thr Arg Trp Tyr Arg 
            100                 105                 110         


Ala Pro Glu Val Ile Leu Asn Trp Met Arg Tyr Thr Gln Thr Val Asp 
        115                 120                 125             


Ile Trp Ser Val Gly Cys Ile Met Ala Glu Met Ile Thr Gly Lys Thr 
    130                 135                 140                 


Leu Phe Lys Gly Ser Asp His Leu Asp Gln Leu Lys Glu Ile Met Lys 
145                 150                 155                 160 


Val Thr Gly Thr Pro Pro Ala Glu Phe Val Gln Arg Leu Gln Ser Asp 
                165                 170                 175     


Glu Ala Lys Asn Tyr Met Lys Gly Leu Pro Glu Leu Glu Lys Lys Asp 
            180                 185                 190         


Phe Ala Ser Ile Leu Thr Asn Ala 
        195                 200 


<210>  69
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide DNA

<400>  69
cgagcgactg ccaggcgttc                                                   20


<210>  70
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide DNA

<400>  70
ggagcggctg ccgggagtgc                                                   20


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide DNA

<400>  71
cccggctctc ccggaacgcc                                                   20


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide DNA

<400>  72
cccggctccc caggcactcc                                                   20


<210>  73
<211>  120
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Donor sequence for CRISPR

<400>  73
ccaggtgaac caccaaaatc cggagaacga agcggctaca gcagccccgg ctctcccgga       60

gagcctggca gtcgctcgcg caccccatcc ctaccaacac cgcccacccg ggagcccaag      120


<210>  74
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  X is Dor E

<400>  74

Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg 
1               5                   10              


<210>  75
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D or E

<400>  75

Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr 
1               5                   10                  15  


<210>  76
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  X is D or E

<400>  76

Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr 
1               5                   10                  15  


<210>  77
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  X is D or E

<400>  77

Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr 
1               5                   10                  15      


Pro 
    


<210>  78
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  X is D or E

<400>  78

Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg 
1               5                   10                  15      


Thr Pro Ser 
            


<210>  79
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  X is D or E

<400>  79

Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser 
1               5                   10                  15      


Arg Thr Pro Ser Leu 
            20      


<210>  80
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  X is D or E

<400>  80

Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser Arg 
1               5                   10                  15      


Ser Arg Thr Pro Ser Leu Pro 
            20              


<210>  81
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  X is D or E

<400>  81

Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly Ser 
1               5                   10                  15      


Arg Ser Arg Thr Pro Ser Leu Pro Thr 
            20                  25  


<210>  82
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  X is D or E

<400>  82

Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro Gly 
1               5                   10                  15      


Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
            20                  25          


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  X is D or E

<400>  83

Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa Pro 
1               5                   10                  15      


Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
            20                  25                  


<210>  84
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  X is D or E

<400>  84

Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly Xaa 
1               5                   10                  15      


Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
            20                  25                  30      


<210>  85
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  X is D or E

<400>  85

Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro Gly 
1               5                   10                  15      


Xaa Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro Thr 
            20                  25                  30          


Arg 
    


<210>  86
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  X is D or E

<400>  86

Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser Pro 
1               5                   10                  15      


Gly Xaa Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro Pro 
            20                  25                  30          


Thr Arg Glu 
        35  


<210>  87
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  X is D or E

<400>  87

Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly Ser 
1               5                   10                  15      


Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr Pro 
            20                  25                  30          


Pro Thr Arg Glu Pro 
        35          


<210>  88
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  X is D or E

<400>  88

Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro Gly 
1               5                   10                  15      


Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro Thr 
            20                  25                  30          


Pro Pro Thr Arg Glu Pro Lys 
        35                  


<210>  89
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  portion of mutant tau


<220>
<221>  MISC_FEATURE
<222>  (21)..(21)
<223>  X is D or E

<400>  89

Ser Gly Glu Pro Pro Lys Ser Gly Asp Arg Ser Gly Tyr Ser Ser Pro 
1               5                   10                  15      


Gly Ser Pro Gly Xaa Pro Gly Ser Arg Ser Arg Thr Pro Ser Leu Pro 
            20                  25                  30          


Thr Pro Pro Thr Arg Glu Pro Lys 
        35                  40  


<210>  90
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  90
gttctgctgc atcttggaca                                                   20


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  91
gaattccgac atgactcagg                                                   20


<210>  92
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  92
gggtgtctcc aatgcctgct tcttcag                                           27


<210>  93
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  93
aagtcaccca gcagggaggt gctcag                                            26


<210>  94
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  94
tgggctgcga aggtagaggt g                                                 21


<210>  95
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  95
gtgtcacgtg ctcagggcct g                                                 21


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  96
ctcagcatcc cacctgtaac                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  97
ccagttgtgt atgtccaccc                                                   20


<210>  98
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  98
aagttcatct gcaccaccg                                                    19


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  99
tgctcaggta gtggttgtcg                                                   20


<210>  100
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  100
aagtcaccca gcagggaggt g                                                 21


<210>  101
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  101
tcgtatgggt acatggccaa ag                                                22


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  102
cagccccggc tctcccgtag                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  103
cgcgagcgac tgccaggagt                                                   20


<210>  104
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  104
tgtatcaaag tgacagagca ggagtgatgc                                        30


<210>  105
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  105
tggtgcttca ggttctcagt agagccaa                                          28


<210>  106
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  106
cctgaaagaa gatcccctgc agaccccc                                          28


<210>  107
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  107
ccagcgtccg tgtcaccc                                                     18


<210>  108
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  108
caagcccagc aatgcctacc tgagtgacgt gagcaagggc gaggagg                     47


<210>  109
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer sequence

<400>  109
cgaggttgtg atgtctgggg gagcatagct cttgtacagc tcgtccatgc c                51


