                               SEQUENCE LISTING

<110> AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.
 
<120> CAR-T CELL COMPOSITIONS AND METHODS OF USE THEREOF

<130> 064466.117

<140>
<141>

<150> 62/903,776
<151> 2019-09-21

<160> 31    

<170> PatentIn version 3.5

<210> 1
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 1
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctagg       60

cccgacatcc agatgaacca gagcccttct tctctgagcg cctctctggg agacaccatc      120

accatcactt gccacgcctc ccagaacatc aacgtctggc tgtcttggta ccagcagaaa      180

cccggcaaca tccccaagct gctgatctac aaggccagca acctgcacac cggagtgcct      240

agcagattca gcggcagcgg aagcggaacc ggctttaccc tgaccatcag cagcctgcag      300

cccgaggaca tcgccaccta ctattgccag cagggccagt cttacccttg gacattcggc      360

ggaggcacca agctggagat caagagaggc ggaggaggaa gcggaggagg aggatcagga      420

ggaggaggat ctcaggtgca gctgcagcag ccaggatcag aactcgtgag acccggagct      480

agcgtgaagc tgtcttgcaa ggccagcggc tacaccttca cctcttgttg gatgcattgg      540

gtgaagcaga gaccaggaca gggcctggag tggattggca acatctaccc cggctacggc      600

aacaccaact acgacgagaa gttcaagaac aaggccaccc tgaccgtgga cacctctagc      660

agcaccgcct acatgcagct gagcggactg acaagcgagg atagcgccgt gtactattgc      720

accaggggca gctacctgta cgccatggac tattggggcc agggaaccag cgtgacagtg      780

tctagcacca ccacaccagc ccctagacct cctacaccag cccctacaat cgcctctcag      840

cctctgagcc tgagacccga agcttgtaga ccagccgcag gaggagctgt gcataccagg      900

ggcctggact tcgcttgcga cttttgggtg ctggtggtcg tgggaggagt gctggcttgt      960

tacagcctgc tggtgaccgt ggctttcatc atcttttggg tcaagagggg ccggaagaag     1020

ctgctgtaca tcttcaagca gcccttcatg aggcccgtgc agacaacaca ggaggaggac     1080

ggctgttctt gcaggttccc agaggaagaa gagggcggtt gcgagctgag agtgaagttc     1140

agcagaagcg ccgacgctcc agcttatcag cagggccaga accagctgta caacgagctg     1200

aacctgggca ggagggagga atacgacgtg ctggacaagc ggagaggcag agatccagag     1260

atgggcggca agcctcagag aaggaagaac ccccaggagg gcctgtacaa cgagctgcag     1320

aaggacaaga tggccgaggc ttacagcgag atcggcatga agggcgagag gagaagaggc     1380

aagggccacg acggactgta ccagggactg agcacagcca ccaaggatac ctacgacgcc     1440

ctgcatatgc aggctctgcc tcccaggtaa                                      1470


<210> 2
<211> 1482
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 2
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga       60

cctgacgtcg tgatgacaca gacccctctg accctgagcg tgacaatcgg acagccagct      120

agcatcagct gcaagagcag ccagtccctc ctggacagcg acggcgagac ctacctgaat      180

tggctgctgc agagaccagg acagtctcct aagcggctga tctacctggt gtccaagctg      240

gacagcggcg tgccagatag attcacaggc agcggaagcg gcaccgattt caccctgaag      300

atcagcagag tggaggccga ggatctggga gtctactact gttggcaggg cacccacttc      360

cctctgacat ttggagccgg caccaagctg gagctgaaaa gaggcggagg aggaagcgga      420

ggaggaggaa gcggaggagg aggaagcgaa gtgaagctgg tggagagcgg aggagatctg      480

gtgaagccag gcggaagcct gaagctgtct tgcgccgcca gcggcttcac cttcagcaga      540

tacggactgt cttgggtccg gcagacacca gagaagcgac tcgagtgggt ggctaccatc      600

agcggaagcg gcagctacac ctactaccca gacagcgtga agggcaggtt caccatcagc      660

cgggacaacg ccaagaacaa cctgtacctg cagatgagca gcctgagaag cgaggacacc      720

gctctgtact attgcgtgcg cagaggcacc tacggctacg acaattgggg ccagggaacc      780

accctgacag tgtctagcac caccacccca gctcctagac ctcctacacc agcccctaca      840

atcgcctctc agcctctgag cctgagacct gaagcttgta gaccagccgc aggaggagct      900

gtgcatacca ggggcctgga cttcgcttgc gacttttggg tgctggtggt cgtgggagga      960

gtgctggctt gttacagcct gctggtgacc gtggctttca tcatcttttg ggtcaagagg     1020

ggccggaaga agctgctgta catcttcaag cagcccttca tgaggcccgt gcagacaaca     1080

caggaggagg acggctgttc ttgcaggttc ccagaggaag aagagggcgg ttgcgagctg     1140

agagtgaagt tcagcagaag cgccgacgct ccagcttatc agcagggcca gaaccagctg     1200

tacaacgagc tgaacctggg caggagggag gaatacgacg tgctggacaa gcggagaggc     1260

agagatccag agatgggcgg caagcctcag agaaggaaga acccccagga gggcctgtac     1320

aacgagctgc agaaggacaa gatggccgag gcttacagcg agatcggcat gaagggcgag     1380

aggagaagag gcaagggcca cgacggactg taccagggac tgagcacagc caccaaggat     1440

acctacgacg ccctgcatat gcaggctctg cctcccaggt aa                        1482


<210> 3
<211> 1470
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 3
atggctctgc cagtgacagc tctgctgctg cctctggctc tgctgctgca cgcagctaga       60

cccgacatcg tgatgaccca gagccagaag ttcatgagca ccagcgtggg ggacagagtg      120

tccgtgactt gcaaggccag ccagaacgtg ggaaccaacg tggcttggta ccagcagaag      180

ccaggacaga gccctaaggc cctgatctac agcgccagct acagatacag cggagtgcca      240

gacagattca ccggcagcgg aagcggcaca gacttcaccc tgaccatcag caacgtgcag      300

agcgaggacc tggccgagta cttttgccag cagtacaaca gctaccccct gaccttcgga      360

gccggaacca agctggagct gaagagagga ggaggaggaa gcggaggagg aggaagcgga      420

ggaggaggat ctcaggtgca gctgcagcag ccaggatcag aactcgtgag accaggagcc      480

agcgtgaagc tgtcttgcaa ggctagcggc tacaccttca ccagctactg gatgcattgg      540

gtgaagcaga gactgggaca gggactggag tggatcggca acatctaccc aggcagcgga      600

agcaccaact acgacgagaa gttcaagagc aagggcaccc tgacagtgga cacctctagc      660

agcaccgcct acatgcacct gagctctctg accagcgagg acagcgccgt gtactattgc      720

accaggggcg actacgattg ggtgttcgct tattggggcc agggcacact ggtgacagtg      780

agcgccacaa caacaccagc ccctagacct cctacaccag cccctacaat cgcctctcag      840

cctctgagcc tgaggccaga agcttgcaga ccagccgcag gaggagctgt gcataccagg      900

ggcctggact tcgcttgcga cttttgggtg ctggtggtcg tgggaggagt gctggcttgt      960

tacagcctgc tggtgaccgt ggctttcatc atcttttggg tcaagagggg ccggaagaag     1020

ctgctgtaca tcttcaagca gcccttcatg aggcccgtgc agacaacaca ggaggaggac     1080

ggctgttctt gcaggttccc agaggaagaa gagggcggtt gcgagctgag agtgaagttc     1140

agcagaagcg ccgacgctcc agcttatcag cagggccaga accagctgta caacgagctg     1200

aacctgggca ggagggagga atacgacgtg ctggacaagc ggagaggcag agatccagag     1260

atgggcggca agcctcagag aaggaagaac ccccaggagg gcctgtacaa cgagctgcag     1320

aaggacaaga tggccgaggc ttacagcgag atcggcatga agggcgagag gagaagaggc     1380

aagggccacg acggactgta ccagggactg agcacagcca ccaaggatac ctacgacgcc     1440

ctgcatatgc aggctctgcc tcccaggtaa                                      1470


<210> 4
<211> 465
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 4
atgagggtcc ttgctgagct cctggggctg ctgctgttct gctttttagg tgtgagatgt       60

gacatccaga tgaaccagtc tccatccagt ctgtctgcat cccttggaga cacaattacc      120

atcacttgcc atgccagtca gaacattaat gtttggttaa gctggtacca gcagaaacca      180

ggaaatattc ctaaactatt gatctataag gcttccaact tgcacacagg cgtcccatca      240

agatttagtg gcagtggatc tggaacaggt ttcacattaa ccatcagcag cctgcagcct      300

gaagacattg ccacttacta ctgtcaacag ggtcaaagtt atccgtggac gttcggtgga      360

ggcaccaagc tggaaatcaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttc                      465


<210> 5
<211> 155
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 5
Met Arg Val Leu Ala Glu Leu Leu Gly Leu Leu Leu Phe Cys Phe Leu 
1               5                   10                  15      


Gly Val Arg Cys Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn 
        35                  40                  45              


Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro 
    50                  55                  60                  


Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln 
            100                 105                 110         


Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155 


<210> 6
<211> 507
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 6
atgggatgga gctctatcat cctcttcttg gtagcaacag cctcaggtgt ccactcccag       60

gtccaactgc agcaacctgg gtctgagctg gtgaggcctg gagcttcagt gaagctgtcc      120

tgcaaggctt ctggctacac tttcaccagc tgctggatgc actgggtgaa gcagaggcct      180

ggacaaggcc ttgagtggat tggaaatatt tatcctggtt atggtaatac taactacgat      240

gagaagttca agaacaaggc cacactgact gtagacacat cctccagcac tgcctacatg      300

cagctcagcg gcctgacatc tgaggactct gcggtctatt attgtacaag aggatcgtat      360

ctctatgcta tggactactg gggtcaagga acctcagtca ccgtctcctc agagagtcag      420

tccttcccaa atgtcttccc cctcgtctcc tgcgagagcc ccctgtctga taagaatctg      480

gtggccatgg gctgcctggc ccgggac                                          507


<210> 7
<211> 169
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Gly Trp Ser Ser Ile Ile Leu Phe Leu Val Ala Thr Ala Ser Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Cys Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Tyr Pro Gly Tyr Gly Asn Thr Asn Tyr Asp 
65                  70                  75                  80  


Glu Lys Phe Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Ser Tyr Leu Tyr Ala Met Asp Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Ser Val Thr Val Ser Ser Glu Ser Gln Ser Phe Pro Asn 
    130                 135                 140                 


Val Phe Pro Leu Val Ser Cys Glu Ser Pro Leu Ser Asp Lys Asn Leu 
145                 150                 155                 160 


Val Ala Met Gly Cys Leu Ala Arg Asp 
                165                 


<210> 8
<211> 450
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 8
atgagtcctg cccagttcct gtttctgtta gtgctctgga ttcgggtttc agaaaccaac       60

ggtgatgttg tgatgaccca gactccactc actttgtcgg ttaccattgg acaaccagcc      120

tccatctctt gcaagtcaag tcagagcctc ttagatagtg atggagagac atatttgaat      180

tggttgttac agaggccagg ccagtctcca aagcgcctaa tctatctggt gtctaaactg      240

gactctggag tccctgacag gttcactggc agtggatcag ggacagattt cacactgaaa      300

atcagcagag tggaggctga agatttggga gtttactatt gctggcaagg tacacatttt      360

cctctcacgt tcggtgctgg gaccaagctg gagctgaaac gggctgatgc tgcaccaact      420

gtatccatct tcccaccatc cagtgaatca                                       450


<210> 9
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 9
Met Ser Pro Ala Gln Phe Leu Phe Leu Leu Val Leu Trp Ile Arg Val 
1               5                   10                  15      


Ser Glu Thr Asn Gly Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu 
            20                  25                  30          


Ser Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu 
65                  70                  75                  80  


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe 
    130                 135                 140                 


Pro Pro Ser Ser Glu Ser 
145                 150 


<210> 10
<211> 420
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 10
atgaacttcg ggctcagctt gattttcctt gtcctaattt taaaaggtgt ccagtgtgaa       60

gtgaagctgg tggagtctgg gggagactta gtgaagcctg gagggtccct gaaactctcc      120

tgtgcagcct ctggattcac tttcagtagg tatggcctgt cttgggttcg ccagactccg      180

gagaagaggc tggagtgggt cgcaaccatt agtggtagtg gtagttacac ctactatcca      240

gacagtgtga aggggcgatt caccatctcc agagacaatg ccaagaacaa cctgtacctc      300

caaatgagca gtctgaggtc tgaggacacg gccttgtatt actgtgtaag acgagggacg      360

tatggttacg acaactgggg ccaaggcacc actctcacag tctcctcagc caaaacaaca      420


<210> 11
<211> 140
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 11
Met Asn Phe Gly Leu Ser Leu Ile Phe Leu Val Leu Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Arg Tyr Gly Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Thr Ile Ser Gly Ser Gly Ser Tyr Thr Tyr Tyr Pro 
65                  70                  75                  80  


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Asn Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu 
            100                 105                 110         


Tyr Tyr Cys Val Arg Arg Gly Thr Tyr Gly Tyr Asp Asn Trp Gly Gln 
        115                 120                 125             


Gly Thr Thr Leu Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140 


<210> 12
<211> 671
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 12
gaaggcgagt cgcatgctcc ggccgccatg gcggccgcgg gaattcgatt cactgccatc       60

aatcttccac ttgtattttg ggctgttatg ttctctctct ttttaataca tcagatcagc      120

atgggcatca agatggagtc acagactcag gtctttgtat acatgttgct gtggttgtct      180

ggtgttgatg gagacattgt gatgacccag tctcaaaaat tcatgtccac atcagtagga      240

gacagggtca gcgtcacctg caaggccagt cagaatgtgg gtactaatgt agcctggtat      300

caacagaaac cagggcaatc tcctaaagca ctgatttact cggcatccta ccggtacagt      360

ggagtccctg atcgcttcac aggcagtgga tctgggacag atttcactct caccatcagc      420

aatgtgcagt ctgaagactt ggcagagtat ttctgtcagc aatataacag ctatcctctc      480

acgttcggtg ctgggaccaa gctggagctg aaacgggctg atgctgcacc aactgtatcc      540

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      600

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaatcacta      660

gtgaattcgc g                                                           671


<210> 13
<211> 179
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Met Glu Ser Gln Thr Gln Val Phe Val Tyr Met Leu Leu Trp Leu Ser 
1               5                   10                  15      


Gly Val Asp Gly Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser 
            20                  25                  30          


Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn 
        35                  40                  45              


Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
                85                  90                  95      


Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn 
            100                 105                 110         


Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg 
        115                 120                 125             


Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln 
    130                 135                 140                 


Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Ser Leu 
                165                 170                 175     


Val Asn Ser 
            


<210> 14
<211> 510
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 14
gaccggtcct tgactaaggt cattgttctc actacagtta ctgagcacac agacctcacc       60

atgggatgga gctgtatcat cctcttcttg gtagcaacag ctacaggtgt ccactcccag      120

gtccaactgc agcaacctgg gtctgagctg gtgaggcctg gagcttcagt gaagctgtcc      180

tgcaaggctt ctggctacac attcaccagc tactggatgc actgggtgaa gcagaggctt      240

ggacaaggcc ttgagtggat tggaaatatt tatcctggta gtggtagtac taactacgat      300

gagaagttca agagcaaggg cacgctgact gtagacacat cctccagcac agcctacatg      360

cacctcagca gcctgacatc tgaggactct gcggtctatt actgtacaag aggtgattac      420

gactgggttt ttgcttactg gggccaaggg actctggtca ctgtctctgc agagagtcag      480

tccttcccaa atgtcttccc ccaatcacta                                       510


<210> 15
<211> 150
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 15
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ser Tyr Trp Met His Trp Val Lys Gln Arg Leu Gly Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asp 
65                  70                  75                  80  


Glu Lys Phe Lys Ser Lys Gly Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Thr Arg Gly Asp Tyr Asp Trp Val Phe Ala Tyr Trp Gly 
        115                 120                 125             


Gln Gly Thr Leu Val Thr Val Ser Ala Glu Ser Gln Ser Phe Pro Asn 
    130                 135                 140                 


Val Phe Pro Gln Ser Leu 
145                 150 


<210> 16
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 16
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
            20                  25                  30          


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Cys 
        35                  40                  45              


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
    50                  55                  60                  


Gly Asn Ile Tyr Pro Gly Tyr Gly Asn Thr Asn Tyr Asp Glu Lys Phe 
65                  70                  75                  80  


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
                85                  90                  95      


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            100                 105                 110         


Thr Arg Gly Ser Tyr Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210> 17
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu Ser Ala Ser Leu Gly 
            20                  25                  30          


Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln Asn Ile Asn Val Trp 
        35                  40                  45              


Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile Pro Lys Leu Leu Ile 
    50                  55                  60                  


Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro Ser Arg Phe Ser Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
                85                  90                  95      


Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly Gln Ser Tyr Pro Trp 
            100                 105                 110         


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210> 18
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly 
            20                  25                  30          


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Tyr 
        35                  40                  45              


Gly Leu Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
    50                  55                  60                  


Ala Thr Ile Ser Gly Ser Gly Ser Tyr Thr Tyr Tyr Pro Asp Ser Val 
65                  70                  75                  80  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Asn Leu Tyr 
                85                  90                  95      


Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
            100                 105                 110         


Val Arg Arg Gly Thr Tyr Gly Tyr Asp Asn Trp Gly Gln Gly Thr Thr 
        115                 120                 125             


Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 19
<211> 236
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 19
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
            20                  25                  30          


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu Asp Ser 
        35                  40                  45              


Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
                85                  90                  95      


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
            100                 105                 110         


Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp 
    130                 135                 140                 


Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn 
145                 150                 155                 160 


Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu 
                165                 170                 175     


Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp 
            180                 185                 190         


Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr 
        195                 200                 205             


Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser 
    210                 215                 220                 


Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235     


<210> 20
<211> 464
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 20
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
            20                  25                  30          


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
        35                  40                  45              


Trp Met His Trp Val Lys Gln Arg Leu Gly Gln Gly Leu Glu Trp Ile 
    50                  55                  60                  


Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asp Glu Lys Phe 
65                  70                  75                  80  


Lys Ser Lys Gly Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
                85                  90                  95      


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
            100                 105                 110         


Thr Arg Gly Asp Tyr Asp Trp Val Phe Ala Tyr Trp Gly Gln Gly Thr 
        115                 120                 125             


Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
    130                 135                 140                 


Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
145                 150                 155                 160 


Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
                165                 170                 175     


Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
            180                 185                 190         


Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
        195                 200                 205             


Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
    210                 215                 220                 


Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210> 21
<211> 231
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 21
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met Ser Thr Ser Val Gly 
            20                  25                  30          


Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
        35                  40                  45              


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Ala Leu Ile 
    50                  55                  60                  


Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro Asp Arg Phe Thr Gly 
65                  70                  75                  80  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
                85                  90                  95      


Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr Asn Ser Tyr Pro Leu 
            100                 105                 110         


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Arg Thr Val Ala 
        115                 120                 125             


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
    130                 135                 140                 


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
145                 150                 155                 160 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
                165                 170                 175     


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
            180                 185                 190         


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
        195                 200                 205             


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
    210                 215                 220                 


Ser Phe Asn Arg Gly Glu Cys 
225                 230     


<210> 22
<211> 489
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 22
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Gln Met Asn Gln Ser Pro Ser Ser Leu 
            20                  25                  30          


Ser Ala Ser Leu Gly Asp Thr Ile Thr Ile Thr Cys His Ala Ser Gln 
        35                  40                  45              


Asn Ile Asn Val Trp Leu Ser Trp Tyr Gln Gln Lys Pro Gly Asn Ile 
    50                  55                  60                  


Pro Lys Leu Leu Ile Tyr Lys Ala Ser Asn Leu His Thr Gly Val Pro 
65                  70                  75                  80  


Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Gly Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Ser Leu Gln Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Gly 
            100                 105                 110         


Gln Ser Tyr Pro Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Cys 
                165                 170                 175     


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Tyr Pro Gly Tyr Gly Asn Thr Asn Tyr Asp Glu Lys Phe 
        195                 200                 205             


Lys Asn Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met Gln Leu Ser Gly Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Gly Ser Tyr Leu Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Ser Val Thr Val Ser Ser Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210> 23
<211> 493
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 23
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu 
            20                  25                  30          


Ser Val Thr Ile Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln 
        35                  40                  45              


Ser Leu Leu Asp Ser Asp Gly Glu Thr Tyr Leu Asn Trp Leu Leu Gln 
    50                  55                  60                  


Arg Pro Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu 
65                  70                  75                  80  


Asp Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr 
            100                 105                 110         


Tyr Cys Trp Gln Gly Thr His Phe Pro Leu Thr Phe Gly Ala Gly Thr 
        115                 120                 125             


Lys Leu Glu Leu Lys Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Glu Val Lys Leu Val Glu Ser Gly Gly Asp Leu 
145                 150                 155                 160 


Val Lys Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe 
                165                 170                 175     


Thr Phe Ser Arg Tyr Gly Leu Ser Trp Val Arg Gln Thr Pro Glu Lys 
            180                 185                 190         


Arg Leu Glu Trp Val Ala Thr Ile Ser Gly Ser Gly Ser Tyr Thr Tyr 
        195                 200                 205             


Tyr Pro Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala 
    210                 215                 220                 


Lys Asn Asn Leu Tyr Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr 
225                 230                 235                 240 


Ala Leu Tyr Tyr Cys Val Arg Arg Gly Thr Tyr Gly Tyr Asp Asn Trp 
                245                 250                 255     


Gly Gln Gly Thr Thr Leu Thr Val Ser Ser Thr Thr Thr Pro Ala Pro 
            260                 265                 270         


Arg Pro Pro Thr Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu 
        275                 280                 285             


Arg Pro Glu Ala Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg 
    290                 295                 300                 


Gly Leu Asp Phe Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly 
305                 310                 315                 320 


Val Leu Ala Cys Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe 
                325                 330                 335     


Trp Val Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro 
            340                 345                 350         


Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys 
        355                 360                 365             


Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe 
    370                 375                 380                 


Ser Arg Ser Ala Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu 
385                 390                 395                 400 


Tyr Asn Glu Leu Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp 
                405                 410                 415     


Lys Arg Arg Gly Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg 
            420                 425                 430         


Lys Asn Pro Gln Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met 
        435                 440                 445             


Ala Glu Ala Tyr Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly 
    450                 455                 460                 


Lys Gly His Asp Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp 
465                 470                 475                 480 


Thr Tyr Asp Ala Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 490             


<210> 24
<211> 489
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 24
Met Ala Leu Pro Val Thr Ala Leu Leu Leu Pro Leu Ala Leu Leu Leu 
1               5                   10                  15      


His Ala Ala Arg Pro Asp Ile Val Met Thr Gln Ser Gln Lys Phe Met 
            20                  25                  30          


Ser Thr Ser Val Gly Asp Arg Val Ser Val Thr Cys Lys Ala Ser Gln 
        35                  40                  45              


Asn Val Gly Thr Asn Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser 
    50                  55                  60                  


Pro Lys Ala Leu Ile Tyr Ser Ala Ser Tyr Arg Tyr Ser Gly Val Pro 
65                  70                  75                  80  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile 
                85                  90                  95      


Ser Asn Val Gln Ser Glu Asp Leu Ala Glu Tyr Phe Cys Gln Gln Tyr 
            100                 105                 110         


Asn Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
        115                 120                 125             


Arg Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gln Val Gln Leu Gln Gln Pro Gly Ser Glu Leu Val Arg Pro Gly Ala 
145                 150                 155                 160 


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
                165                 170                 175     


Trp Met His Trp Val Lys Gln Arg Leu Gly Gln Gly Leu Glu Trp Ile 
            180                 185                 190         


Gly Asn Ile Tyr Pro Gly Ser Gly Ser Thr Asn Tyr Asp Glu Lys Phe 
        195                 200                 205             


Lys Ser Lys Gly Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
    210                 215                 220                 


Met His Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Thr Arg Gly Asp Tyr Asp Trp Val Phe Ala Tyr Trp Gly Gln Gly Thr 
                245                 250                 255     


Leu Val Thr Val Ser Ala Thr Thr Thr Pro Ala Pro Arg Pro Pro Thr 
            260                 265                 270         


Pro Ala Pro Thr Ile Ala Ser Gln Pro Leu Ser Leu Arg Pro Glu Ala 
        275                 280                 285             


Cys Arg Pro Ala Ala Gly Gly Ala Val His Thr Arg Gly Leu Asp Phe 
    290                 295                 300                 


Ala Cys Asp Phe Trp Val Leu Val Val Val Gly Gly Val Leu Ala Cys 
305                 310                 315                 320 


Tyr Ser Leu Leu Val Thr Val Ala Phe Ile Ile Phe Trp Val Lys Arg 
                325                 330                 335     


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
            340                 345                 350         


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
        355                 360                 365             


Glu Glu Glu Gly Gly Cys Glu Leu Arg Val Lys Phe Ser Arg Ser Ala 
    370                 375                 380                 


Asp Ala Pro Ala Tyr Gln Gln Gly Gln Asn Gln Leu Tyr Asn Glu Leu 
385                 390                 395                 400 


Asn Leu Gly Arg Arg Glu Glu Tyr Asp Val Leu Asp Lys Arg Arg Gly 
                405                 410                 415     


Arg Asp Pro Glu Met Gly Gly Lys Pro Gln Arg Arg Lys Asn Pro Gln 
            420                 425                 430         


Glu Gly Leu Tyr Asn Glu Leu Gln Lys Asp Lys Met Ala Glu Ala Tyr 
        435                 440                 445             


Ser Glu Ile Gly Met Lys Gly Glu Arg Arg Arg Gly Lys Gly His Asp 
    450                 455                 460                 


Gly Leu Tyr Gln Gly Leu Ser Thr Ala Thr Lys Asp Thr Tyr Asp Ala 
465                 470                 475                 480 


Leu His Met Gln Ala Leu Pro Pro Arg 
                485                 


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer


<220>
<221> modified_base
<222> (8)..(9)
<223> Inosine

<220>
<221> modified_base
<222> (13)..(14)
<223> Inosine

<220>
<221> modified_base
<222> (18)..(19)
<223> Inosine

<400> 25
caccgggnng ggnngggnng g                                                 21


<210> 26
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
cctggatgac ttcagtgttg ttctg                                             25


<210> 27
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
cactgccatc aatcttccac ttg                                               23


<210> 28
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
gggggaagac atttgggaag g                                                 21


<210> 29
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 29
cactggatgg tgggaagatg g                                                 21


<210> 30
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 30
ggttacagtc actgagctgc tg                                                22


<210> 31
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 31
ggagccagtt gtatctccac ac                                                22


