
                                SEQUENCE LISTING

<110> Denali Therapeuctics, Inc.

<120> ANTI-ALPHA-SYNUCLEIN ANTIBODIES AND METHODS OF 
      USE THEREOF

<130> 260114.422WO

<140> PCT
<141> 2020-09-18

<150> US 62/903,588
<151> 2019-09-20

<160> 233

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 140
<212> PRT
<213> Homo sapiens

<400> 1
Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val
 1               5                  10                  15
Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys
            20                  25                  30
Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val
        35                  40                  45
Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr
    50                  55                  60
Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys
65                  70                  75                  80
Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys
                85                  90                  95
Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile
            100                 105                 110
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro
        115                 120                 125
Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala
    130                 135                 140

<210> 2
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 1H5

<400> 2
Gly Phe Thr Phe Ser Asp Ala Ala Met Tyr
 1               5                  10

<210> 3
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 20H4

<400> 3
Gly Phe Thr Phe Ser Asn Ala Ala Met Tyr
 1               5                  10

<210> 4
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 22D11

<400> 4
Gly Phe Thr Phe Thr Asn Ala Ala Ile Tyr
 1               5                  10

<210> 5
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 16F3

<400> 5
Gly Phe Thr Phe Ser Asn Gly Ala Met Asn
 1               5                  10

<210> 6
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 18B4

<400> 6
Gly Phe Thr Phe Ser Ser Phe Ala Met Ala
 1               5                  10

<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 for clone 22E11

<400> 7
Gly Phe Thr Phe Ser Thr Ala Ala Met Tyr
 1               5                  10

<210> 8
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H2 for clones 1H5, 16F3,
      and 22E11

<400> 8
Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 9
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H2 for clone 20H4

<400> 9
Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 10
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H2 for clone 18B4

<400> 10
Thr Ile Thr Ser Gly Gly Ser Lys Thr Tyr Tyr Pro Asp Ser Val Lys
 1               5                  10                  15
Gly


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 1H5

<400> 11
Ser Ala Asp Phe His Tyr Phe Asp Tyr
 1               5

<210> 12
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 20H4

<400> 12
Thr Ala Asp Met Ala Thr Gly Asp Tyr
 1               5

<210> 13
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 22D11

<400> 13
Ala Ala Asp Ala Ser Arg Gly Asp Tyr
 1               5

<210> 14
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 16F3

<400> 14
Thr Ala Asp Gly Ala Thr Pro Phe Ala Tyr
 1               5                  10

<210> 15
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 18B4

<400> 15
Ala Lys Gly Tyr Phe Asp Tyr
 1               5

<210> 16
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 for clone 22E11

<400> 16
Thr Ala Asp Tyr Tyr Asp Gly Thr Pro Phe Ala Tyr
 1               5                  10

<210> 17
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 1H5

<400> 17
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met
65                  70                  75                  80
Val Tyr Leu Gln Met Gly Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Ser Ala Asp Phe His Tyr Phe Asp Tyr Trp Gly Gln Gly Val
            100                 105                 110
Met Val Thr Val Ser Ser
        115

<210> 18
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 20H4

<400> 18
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65                  70                  75                  80
Val Tyr Leu His Met Gly Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Pro Gly Val
            100                 105                 110
Met Val Thr Val Ser Ser
        115

<210> 19
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 22D11

<400> 19
Ala Val Gln Phe Val Glu Ser Gly Gly Gly Leu Val Arg Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Thr Ala Ser Gly Phe Thr Phe Thr Asn Ala
            20                  25                  30
Ala Ile Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Cys Ile
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
    50                  55                  60
Ser Val Arg Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Pro Met
65                  70                  75                  80
Val Tyr Leu Gln Met Asn Glu Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Ala Ala Asp Ala Ser Arg Gly Asp Tyr Trp Gly Gln Gly Val
            100                 105                 110
Met Val Thr Val Ser Ser
        115

<210> 20
<211> 119
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 16F3

<400> 20
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Gly
            20                  25                  30
Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met
65                  70                  75                  80
Val Tyr Leu Gln Met Asp Asp Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Gly Ala Thr Pro Phe Ala Tyr Trp Gly Gln Gly
            100                 105                 110
Thr Leu Val Thr Val Ser Ser
        115

<210> 21
<211> 114
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 18B4

<400> 21
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg
 1               5                  10                  15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe
            20                  25                  30
Ala Met Ala Trp Val Arg Gln Ala Pro Lys Lys Gly Leu Glu Trp Val
        35                  40                  45
Ala Thr Ile Thr Ser Gly Gly Ser Lys Thr Tyr Tyr Pro Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Ser Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys
                85                  90                  95
Ala Lys Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Val Met Val Thr Val
            100                 105                 110
Ser Ser


<210> 22
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VH for clone 22E11

<400> 22
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Thr Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Met
65                  70                  75                  80
Val Tyr Leu Gln Met Asp Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Tyr Tyr Asp Gly Thr Pro Phe Ala Tyr Trp Gly
            100                 105                 110
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120

<210> 23
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L1 for clone 1H5

<400> 23
Lys Ala Gly Gln Asn Ile Asn Lys Asn Leu Asp
 1               5                  10

<210> 24
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L1 for clones 20H4 ,
      22D11, 20H4_LC_k3_2_v1, and 20H4_LC_k3_2_v2

<400> 24
Lys Ala Ser Gln Asn Ile Asn Lys Asn Leu Asp
 1               5                  10

<210> 25
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L1 for clones 16F3 and 18B4

<400> 25
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Asn Thr Tyr Leu His
 1               5                  10                  15

<210> 26
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L1 for clone 22E11

<400> 26
Arg Ser Ser Gln Ser Leu Val His Asn Asn Gly Ile Thr Tyr Leu Ser
 1               5                  10                  15

<210> 27
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 for clones 1H5 and 22D11

<400> 27
Phe Thr Asn Asn Leu Gln Thr
 1               5

<210> 28
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 for clone 20H4 and
      20H4_LC_k3_2_v2

<400> 28
Ser Thr Asn Asn Leu Gln Thr
 1               5

<210> 29
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 for clones 16F3 and 18B4

<400> 29
Leu Val Ser Arg Leu Glu Ser
 1               5

<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 for clone 22E11

<400> 30
Lys Val Ser Asn Arg Phe Ser
 1               5

<210> 31
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 1H5

<400> 31
Tyr Gln Tyr Asn Ser Gly Trp Thr
 1               5

<210> 32
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 20H4

<400> 32
Tyr Gln Tyr Lys Ser Ala Trp Thr
 1               5

<210> 33
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 22D11

<400> 33
Tyr Gln Tyr Thr Ser Gly Phe Thr
 1               5

<210> 34
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 16F3

<400> 34
Val Gln Gly Thr His Ala Pro Phe Thr
 1               5

<210> 35
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 18B4

<400> 35
Val Gln Gly Thr His Ala Pro Leu Thr
 1               5

<210> 36
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 for clone 22E11

<400> 36
Gly Gln Gly Thr Gln Tyr Pro Tyr Thr
 1               5

<210> 37
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VL for clone 1H5

<400> 37
Asp Ile Gln Met Thr Gln Ser Pro Ser Val Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Leu Ser Cys Lys Ala Gly Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Leu Gly Glu Ala Pro Lys Leu Leu Ile
        35                  40                  45
Ser Phe Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Ser Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Asn Ser Gly Trp Thr
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Glu Leu Lys
            100                 105

<210> 38
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VL for clone 20H4

<400> 38
Asp Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Val Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Glu Leu Arg
            100                 105

<210> 39
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VL for clone 22D11

<400> 39
Asp Ile Gln Met Thr Gln Ser Pro Ser Val Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Phe Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Leu Gly Glu Val Pro Lys Val Leu Ile
        35                  40                  45
Tyr Phe Thr Asn Asn Leu Gln Thr Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Thr Ser Gly Phe Thr
                85                  90                  95
Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105

<210> 40
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VL for clone 16F3

<400> 40
Asp Val Val Leu Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly
 1               5                  10                  15
Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
            20                  25                  30
Asn Gly Asn Thr Tyr Leu His Trp Leu Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45
Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Gly Val Pro
    50                  55                  60
Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80
Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
                85                  90                  95
Thr His Ala Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110

<210> 41
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VLfor clone 18B4

<400> 41
Asp Val Val Leu Thr Gln Thr Pro Pro Thr Leu Ser Ala Thr Ile Gly
 1               5                  10                  15
Gln Ser Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser
            20                  25                  30
Asn Gly Asn Thr Tyr Leu His Trp Leu Leu Gln Arg Pro Gly Gln Ser
        35                  40                  45
Pro Gln Leu Leu Ile Tyr Leu Val Ser Arg Leu Glu Ser Gly Val Pro
    50                  55                  60
Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80
Ser Gly Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Val Gln Gly
                85                  90                  95
Thr His Ala Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys
            100                 105                 110

<210> 42
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence VL for clone 22E11

<400> 42
Ala Val Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly
 1               5                  10                  15
Gly Gln Val Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Asn
            20                  25                  30
Asn Gly Ile Thr Tyr Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser
        35                  40                  45
Pro Gln Leu Pro Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Phe Ser
    50                  55                  60
Asp Arg Phe Ser Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile
65                  70                  75                  80
Ser Arg Val Glu Pro Asp Asp Leu Gly Leu Tyr Tyr Cys Gly Gln Gly
                85                  90                  95
Thr Gln Tyr Pro Tyr Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys
            100                 105                 110

<210> 43
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H1 consensus sequence

<220>
<221> VARIANT        
<222> 3,5,6,7,9,10
<223> Xaa = any amino acid

<400> 43
Gly Phe Xaa Phe Xaa Xaa Xaa Ala Xaa Xaa
 1               5                  10

<210> 44
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H2 consensus sequence

<220>
<221> VARIANT        
<222> 13,18
<223> Xaa = any amino acid

<400> 44
Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Xaa Ala Asp Ser
 1               5                  10                  15
Val Xaa Gly


<210> 45
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H2 consensus sequence

<220>
<221> VARIANT        
<222> 3,4,8
<223> Xaa = any amino acid

<400> 45
Thr Tyr Xaa Xaa Asp Ser Val Xaa Gly
 1               5

<210> 46
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-H3 consensus sequence

<220>
<221> VARIANT        
<222> 1,4,5,6,7
<223> Xaa = any amino acid

<400> 46
Xaa Ala Asp Xaa Xaa Xaa Xaa Asp Tyr
 1               5

<210> 47
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L1 consensus sequence

<220>
<221> VARIANT        
<222> 3,5,8,9
<223> Xaa = any amino acid


<400> 47
Lys Ala Xaa Gln Xaa Ile Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 48
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L1 consensus sequence

<220>
<221> VARIANT        
<222> 7,9,12,16
<223> Xaa = any amino acid


<400> 48
Arg Ser Ser Gln Ser Leu Xaa His Xaa Asn Gly Xaa Thr Tyr Leu Xaa
 1               5                  10                  15

<210> 49
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 consensus sequence

<220>
<221> VARIANT        
<222> 1,3,4,6
<223> Xaa = any amino acid

<400> 49
Xaa Thr Xaa Xaa Leu Xaa Thr
 1               5

<210> 50
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L2 consensus sequence

<220>
<221> VARIANT        
<222> 1,4,5,6
<223> Xaa = any amino acid

<400> 50
Xaa Val Ser Xaa Xaa Xaa Ser
 1               5

<210> 51
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 consensus sequence

<220>
<221> VARIANT        
<222> (3)...(7)
<223> Xaa = any amino acid

<400> 51
Tyr Gln Xaa Xaa Xaa Xaa Xaa Thr
 1               5

<210> 52
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence CDR-L3 consensus sequence

<220>
<221> VARIANT        
<222> 1,5,6,8
<223> Xaa = any amino acid

<400> 52
Xaa Gln Gly Thr Xaa Xaa Pro Xaa Thr
 1               5

<210> 53
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> ratIgG1 VH 3' PCR primer

<400> 53
aggcttgcaa tcacctccac a                                                21

<210> 54
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> ratIgG2a VH 3' PCR primer

<400> 54
acaaggattg cattcccttg g                                                21

<210> 55
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> ratIgG2b VH 3' PCR primer

<400> 55
gcatttgtgt ccaatgccgc c                                                21

<210> 56
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> ratIgG2c VH 3' PCR primer

<400> 56
tctgggcttg ggtcttctgg g                                                21

<210> 57
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> ratCkappa VL 3' primer

<400> 57
ctcattcctg ttgaagctct tgacgacggg                                       30

<210> 58
<211> 46
<212> PRT
<213> Homo sapiens

<400> 58
Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu
 1               5                  10                  15
Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu
            20                  25                  30
Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala
        35                  40                  45

<210> 59
<211> 29
<212> PRT
<213> Homo sapiens

<400> 59
Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15
Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala
            20                  25

<210> 60
<211> 20
<212> PRT
<213> Homo sapiens

<400> 60
Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu
 1               5                  10                  15
Met Pro Ser Glu
            20

<210> 61
<211> 15
<212> PRT
<213> Homo sapiens

<400> 61
Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr
 1               5                  10                  15

<210> 62
<211> 15
<212> PRT
<213> Homo sapiens

<400> 62
Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu
 1               5                  10                  15

<210> 63
<211> 15
<212> PRT
<213> Homo sapiens

<400> 63
Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
 1               5                  10                  15

<210> 64
<211> 217
<212> PRT
<213> Homo sapiens

<400> 64
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 65
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Chimeric 20H4 (Chi 20H4) light
      chain

<400> 65
Asp Ile Gln Met Thr Gln Ser Pro Pro Val Leu Ser Val Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys His Gly Glu Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Val Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gly Gly Thr Lys Leu Glu Leu Arg Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 66
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Chimeric 20H4 (Chi 20H4) heavy
      chain sequence (wild-type human Fc)

<400> 66
Ala Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Glu
 1               5                  10                  15
Ser Leu Lys Ile Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Met
65                  70                  75                  80
Val Tyr Leu His Met Gly Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Pro Gly Val
            100                 105                 110
Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 67
<211> 15
<212> PRT
<213> Homo sapiens

<400> 67
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 68
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Peptide containing alanine
      substitution at position 113 of SEQ ID NO:1

<400> 68
Ala Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 69
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Peptide containing alanine
      substitution at position 114 of SEQ ID NO:1

<400> 69
Leu Ala Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 70
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence Peptide containing alanine
      substitution at position 115 of SEQ ID NO:1

<400> 70
Leu Glu Ala Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 71
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 116 of SEQ ID NO:1

<400> 71
Leu Glu Asp Ala Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 72
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 117 of SEQ ID NO:1

<400> 72
Leu Glu Asp Met Ala Val Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 73
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 118 of SEQ ID NO:1

<400> 73
Leu Glu Asp Met Pro Ala Asp Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 74
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 119 of SEQ ID NO:1

<400> 74
Leu Glu Asp Met Pro Val Ala Pro Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 75
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 120 of SEQ ID NO:1

<400> 75
Leu Glu Asp Met Pro Val Asp Ala Asp Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 76
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 121 of SEQ ID NO:1

<400> 76
Leu Glu Asp Met Pro Val Asp Pro Ala Asn Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 77
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 122 of SEQ ID NO:1

<400> 77
Leu Glu Asp Met Pro Val Asp Pro Asp Ala Glu Ala Tyr Glu Met
 1               5                  10                  15

<210> 78
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 123 of SEQ ID NO:1

<400> 78
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Ala Ala Tyr Glu Met
 1               5                  10                  15

<210> 79
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing glycine
      substitution at position 124 of SEQ ID NO:1

<400> 79
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Gly Tyr Glu Met
 1               5                  10                  15

<210> 80
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing proline
      substitution at position 124 of SEQ ID NO:1

<400> 80
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Pro Tyr Glu Met
 1               5                  10                  15

<210> 81
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 125 of SEQ ID NO:1

<400> 81
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Ala Glu Met
 1               5                  10                  15

<210> 82
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 126 of SEQ ID NO:1

<400> 82
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Ala Met
 1               5                  10                  15

<210> 83
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Peptide containing alanine
      substitution at position 127 of SEQ ID NO:1

<400> 83
Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Ala
 1               5                  10                  15

<210> 84

<400> 84
 000

<210> 85

<400> 85
 000

<210> 86
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - Epitope sequence (amino acids
      119-125 within SEQ ID NO:1)

<400> 86
Asp Pro Asp Asn Glu Ala Tyr
 1               5

<210> 87
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-H1 consensus sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = T, R, K, or N

<220>
<221> VARIANT        
<222> 5
<223> Xaa = N, S, or T

<220>
<221> VARIANT        
<222> 6
<223> Xaa = N, K, R, D, S, or T

<220>
<221> VARIANT        
<222> 7
<223> Xaa = A, G, or F

<220>
<221> VARIANT        
<222> 9
<223> Xaa = I or M

<220>
<221> VARIANT        
<222> 10
<223> Xaa = Y, N, or A

<400> 87
Gly Phe Xaa Phe Xaa Xaa Xaa Ala Xaa Xaa
 1               5                  10

<210> 88
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-H2 consensus sequence

<220>
<221> VARIANT        
<222> 13
<223> Xaa = Y or H

<220>
<221> VARIANT        
<222> 18
<223> Xaa = K or R

<400> 88
Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Xaa Ala Asp Ser
 1               5                  10                  15
Val Xaa Gly


<210> 89
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-H2 consensus sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Y or H

<220>
<221> VARIANT        
<222> 4
<223> Xaa = A or P

<220>
<221> VARIANT        
<222> 8
<223> Xaa = K or R

<400> 89
Thr Tyr Xaa Xaa Asp Ser Val Xaa Gly
 1               5

<210> 90
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-H3 consensus sequence

<220>
<221> VARIANT        
<222> 1
<223> Xaa = T or S

<220>
<221> VARIANT        
<222> 4
<223> Xaa = F, M, or A

<220>
<221> VARIANT        
<222> 5
<223> Xaa = H, A, or S

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Y, T, or R

<220>
<221> VARIANT        
<222> 7
<223> Xaa = F or G

<400> 90
Xaa Ala Asp Xaa Xaa Xaa Xaa Asp Tyr
 1               5

<210> 91
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L1 consensus sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = G or S

<220>
<221> VARIANT        
<222> 5
<223> Xaa = N or I

<220>
<221> VARIANT        
<222> 8
<223> Xaa = K, N, Q, D, or A

<220>
<221> VARIANT        
<222> 9
<223> Xaa = N or I

<400> 91
Lys Ala Xaa Gln Xaa Ile Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 92
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L1 consensus sequence

<220>
<221> VARIANT        
<222> 7
<223> Xaa = L or V

<220>
<221> VARIANT        
<222> 9
<223> Xaa = S or N

<220>
<221> VARIANT        
<222> 12
<223> Xaa = N or I

<220>
<221> VARIANT        
<222> 16
<223> Xaa = H or S

<400> 92
Arg Ser Ser Gln Ser Leu Xaa His Xaa Asn Gly Xaa Thr Tyr Leu Xaa
 1               5                  10                  15

<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L2 consensus sequence

<220>
<221> VARIANT        
<222> 1
<223> Xaa = F, R, or S

<220>
<221> VARIANT        
<222> 3
<223> Xaa = N or K

<220>
<221> VARIANT        
<222> 4
<223> Xaa = N or K

<220>
<221> VARIANT        
<222> 6
<223> Xaa = Q or K

<400> 93
Xaa Thr Xaa Xaa Leu Xaa Thr
 1               5

<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L2 consensus sequence

<220>
<221> VARIANT        
<222> 1
<223> Xaa =  L or K

<220>
<221> VARIANT        
<222> 4
<223> Xaa = R or N

<220>
<221> VARIANT        
<222> 5
<223> Xaa = L or R

<220>
<221> VARIANT        
<222> 6
<223> Xaa = E or F

<400> 94
Xaa Val Ser Xaa Xaa Xaa Ser
 1               5

<210> 95
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L3 consensus sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Y, D, or F

<220>
<221> VARIANT        
<222> 4
<223> Xaa = T, N, or K

<220>
<221> VARIANT        
<222> 5
<223> Xaa = S, N, R, K, Y, L, or F

<220>
<221> VARIANT        
<222> 6
<223> Xaa = A or G

<220>
<221> VARIANT        
<222> 7
<223> Xaa = W or F

<400> 95
Tyr Gln Xaa Xaa Xaa Xaa Xaa Thr
 1               5

<210> 96
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L3 consensus sequence

<220>
<221> VARIANT        
<222> 1
<223> Xaa = V or G

<220>
<221> VARIANT        
<222> 5
<223> Xaa = H or Q

<220>
<221> VARIANT        
<222> 6
<223> Xaa = A or Y

<220>
<221> VARIANT        
<222> 8
<223> Xaa = F, L, or Y

<400> 96
Xaa Gln Gly Thr Xaa Xaa Pro Xaa Thr
 1               5

<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_1 CDR-H1 sequence

<400> 97
Gly Phe Thr Phe Ser Lys Ala Ala Met Tyr
 1               5                  10

<210> 98
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_2 CDR-H1 sequence

<400> 98
Gly Phe Arg Phe Ser Lys Ala Ala Met Tyr
 1               5                  10

<210> 99
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_3 CDR-H1 sequence

<400> 99
Gly Phe Thr Phe Ser Arg Ala Ala Met Tyr
 1               5                  10

<210> 100
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_4 CDR-H1 sequence

<400> 100
Gly Phe Thr Phe Asn Lys Ala Ala Met Tyr
 1               5                  10

<210> 101
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_5 CDR-H1 sequence

<400> 101
Gly Phe Lys Phe Ser Lys Ala Ala Met Tyr
 1               5                  10

<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_6 CDR-H1 sequence

<400> 102
Gly Phe Asn Phe Ser Lys Ala Ala Met Tyr
 1               5                  10

<210> 103
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H1 consensus
      sequence

<220>
<221> VARIANT        
<222> 3,5,6
<223> Xaa = any amino acid

<400> 103
Gly Phe Xaa Phe Xaa Xaa Ala Ala Met Tyr
 1               5                  10

<210> 104
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H1 consensus
      sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = T, R, K, or N

<220>
<221> VARIANT        
<222> 5
<223> Xaa = S or N

<220>
<221> VARIANT        
<222> 6
<223> Xaa = N, K, or R

<400> 104
Gly Phe Xaa Phe Xaa Xaa Ala Ala Met Tyr
 1               5                  10

<210> 105
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_1 CDR-H2 sequence

<400> 105
Arg Ile Arg Thr Lys Pro Asn Asn Phe Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 106
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_2 CDR-H2 sequence

<400> 106
Arg Ile Arg Thr Gln Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 107
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_3 CDR-H2 sequence

<400> 107
Arg Ile Arg Thr Glu Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 108
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_4 CDR-H2 sequence

<400> 108
Arg Ile Arg Thr Lys Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 109
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_5 CDR-H2 sequence

<400> 109
Arg Ile Arg Thr Glu Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 110
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_6 CDR-H2 sequence

<400> 110
Arg Ile Arg Thr Lys Pro Lys Asn Tyr Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 111
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H2 consensus
      sequence

<220>
<221> VARIANT        
<222> 5,6,7,9
<223> Xaa = any amino acid


<400> 111
Arg Ile Arg Thr Xaa Xaa Xaa Asn Xaa Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 112
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H2 consensus
      sequence

<220>
<221> VARIANT        
<222> 5
<223> Xaa =K, Q, or E

<220>
<221> VARIANT        
<222> 6
<223> Xaa = P or R

<220>
<221> VARIANT        
<222> 7
<223> Xaa = N or K

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Y or F

<400> 112
Arg Ile Arg Thr Xaa Xaa Xaa Asn Xaa Ala Thr Tyr His Ala Asp Ser
 1               5                  10                  15
Val Lys Gly


<210> 113
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_1 CDR-H3 sequence

<400> 113
Thr Ala Asn Met Ala Thr Gly Asp Tyr
 1               5

<210> 114
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_2 CDR-H3 sequence

<400> 114
Thr Ala Asn Met Ala Lys Gly Asp Tyr
 1               5

<210> 115
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_3 CDR-H3 sequence

<400> 115
Ala Ala Ala Met Ala Arg Gly Asp Tyr
 1               5

<210> 116
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_4 CDR-H3 sequence

<400> 116
Ser Ala Asp Phe Ala Lys Gly Asp Tyr
 1               5

<210> 117
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_5 CDR-H3 sequence

<400> 117
Thr Ala Asp Phe Ala Arg Gly Asp Tyr
 1               5

<210> 118
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_6 CDR-H3 sequence

<400> 118
Thr Ala Asn Met Arg Lys Gly Asp Tyr
 1               5

<210> 119
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_7 CDR-H3 sequence
      

<400> 119
Thr Ala Asp Met Ala Lys Gly Asp Tyr
 1               5

<210> 120
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H3 consensus sequence
      
<220>
<221> VARIANT        
<222> 1,3,4,5,6
<223> Xaa = any amino acid

<400> 120
Xaa Ala Xaa Xaa Xaa Xaa Gly Asp Tyr
 1               5

<210> 121
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-H3 consensus
      sequence
      
<220>
<221> VARIANT        
<222> 1
<223> Xaa = T, A, or S

<220>
<221> VARIANT        
<222> 3
<223> Xaa = D, N, or A

<220>
<221> VARIANT        
<222> 4
<223> Xaa = M or F

<220>
<221> VARIANT        
<222> 5
<223> Xaa = A or R

<220>
<221> VARIANT        
<222> 6
<223> Xaa = T, K, or R

<400> 121
Xaa Ala Xaa Xaa Xaa Xaa Gly Asp Tyr
 1               5

<210> 122
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L1_1 CDR-L1 and
      20H4_LC_k3_1 CDR-L1 sequence

<400> 122
Lys Ala Ser Gln Asn Ile Asn Asn Asn Leu Asp
 1               5                  10

<210> 123
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L1_2 CDR-L1 sequence
      

<400> 123
Lys Ala Ser Gln Ile Ile Asn Gln Ile Leu Asp
 1               5                  10

<210> 124
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence
      
<220>
<221> VARIANT        
<222> 5, 8, 9
<223> Xaa = any amino acid


<400> 124
Lys Ala Ser Gln Xaa Ile Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 125
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence
      
<220>
<221> VARIANT        
<222> 5
<223> Xaa = N or I

<220>
<221> VARIANT        
<222> 8
<223> Xaa = K, N, Q, D, or A

<220>
<221> VARIANT        
<222> 9
<223> Xaa = N or I

<400> 125
Lys Ala Ser Gln Xaa Ile Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 126
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L2_1 CDR-L2 sequence
      

<400> 126
Ser Thr Asn Lys Leu Lys Thr
 1               5

<210> 127
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L2_2 CDR-L2 sequence

<400> 127
Arg Thr Lys Asn Leu Gln Thr
 1               5

<210> 128
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-L2 sequence 20H4_L1_1,
      20H4_LC_k3_1, and 20H4_LC_k3_2_v1

<400> 128
Ser Thr Asn Asn Leu Lys Thr
 1               5

<210> 129
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L2 consensus
      sequence

<220>
<221> VARIANT        
<222> 1,3, 4, 6
<223> Xaa = any amino acid

<400> 129
Xaa Thr Xaa Xaa Leu Xaa Thr
 1               5

<210> 130
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L2 consensus
      sequence

<220>
<221> VARIANT        
<222> 1
<223> Xaa = S or R

<220>
<221> VARIANT        
<222> 3
<223> Xaa = N or K

<220>
<221> VARIANT        
<222> 4
<223> Xaa = N or K

<220>
<221> VARIANT        
<222> 6
<223> Xaa =  Q or K

<400> 130
Xaa Thr Xaa Xaa Leu Xaa Thr
 1               5

<210> 131
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_1 CDR-L3 sequence

<400> 131
Tyr Gln Asp Lys Asn Gly Trp Thr
 1               5

<210> 132
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_2 CDR-L3 sequence

<400> 132
Tyr Gln Asp Lys Arg Gly Trp Thr
 1               5

<210> 133
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_3 CDR-L3 sequence

<400> 133
Tyr Gln Asp Lys Lys Gly Trp Thr
 1               5

<210> 134
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_4 CDR-L3 sequence

<400> 134
Tyr Gln Asp Lys Ser Gly Trp Thr
 1               5

<210> 135
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_5 CDR-L3 sequence

<400> 135
Tyr Gln Tyr Lys Asn Ala Trp Thr
 1               5

<210> 136
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_6 CDR-L3 sequence

<400> 136
Tyr Gln Tyr Lys Lys Ala Trp Thr
 1               5

<210> 137
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_7 CDR-L3 sequence

<400> 137
Tyr Gln Tyr Lys Asn Gly Trp Thr
 1               5

<210> 138
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_8 CDR-L3 sequence

<400> 138
Tyr Gln Phe Lys Lys Ala Trp Thr
 1               5

<210> 139
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_9 CDR-L3 sequence

<400> 139
Tyr Gln Tyr Lys Tyr Ala Trp Thr
 1               5

<210> 140
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_10 CDR-L3 sequence

<400> 140
Tyr Gln Tyr Lys Leu Ala Trp Thr
 1               5

<210> 141
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_11 CDR-L3 sequence

<400> 141
Tyr Gln Tyr Lys Phe Ala Trp Thr
 1               5

<210> 142
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L3 consensus
      sequence

<220>
<221> VARIANT        
<222> 3,5,6
<223> Xaa = any amino acid

<400> 142
Tyr Gln Xaa Lys Xaa Xaa Trp Thr
 1               5

<210> 143
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L3 consensus
      sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = Y, D, or F

<220>
<221> VARIANT        
<222> 5
<223> Xaa = S, N, R, K, Y, L, or F

<220>
<221> VARIANT        
<222> 6
<223> Xaa = A or G

<400> 143
Tyr Gln Xaa Lys Xaa Xaa Trp Thr
 1               5

<210> 144
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC2

<400> 144
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 145
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC3

<400> 145
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 146
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC4

<400> 146
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 147
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC5

<400> 147
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 148
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_1

<400> 148
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 149
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_2

<400> 149
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Arg Phe Ser Lys Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 150
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_3

<400> 150
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Arg Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 151
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_4

<400> 151
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Lys Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 152
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_5

<400> 152
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Lys Phe Ser Lys Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 153
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H1_6

<400> 153
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Phe Ser Lys Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 154
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_1

<400> 154
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Phe Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 155
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_2

<400> 155
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Gln Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 156
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_3

<400> 156
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Glu Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 157
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_4

<400> 157
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Arg Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 158
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_5

<400> 158
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Glu Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 159
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H2_6

<400> 159
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Lys Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 160
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_1

<400> 160
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asn Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 161
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_2

<400> 161
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asn Met Ala Lys Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 162
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_3

<400> 162
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Ala Ala Ala Met Ala Arg Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 163
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_4

<400> 163
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Ser Ala Asp Phe Ala Lys Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 164
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_5

<400> 164
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Phe Ala Arg Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 165
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_6

<400> 165
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asn Met Arg Lys Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 166
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_H3_7

<400> 166
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Lys Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 167
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC1

<400> 167
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 168
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC2

<400> 168
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 169
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC3

<400> 169
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 170
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC4

<400> 170
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 171
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC5

<400> 171
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 172
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC6

<400> 172
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 173
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L1_1

<400> 173
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Asn Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 174
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L1_2

<400> 174
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ile Ile Asn Gln Ile
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 175
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L2_1

<400> 175
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Lys Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 176
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L2_2

<400> 176
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Lys Ser Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Arg Thr Lys Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 177
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_1

<400> 177
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Asp Lys Asn Gly Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 178
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_2

<400> 178
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Asp Lys Arg Gly Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 179
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_3

<400> 179
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Asp Lys Lys Gly Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 180
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_4

<400> 180
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Asp Lys Ser Gly Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 181
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_5

<400> 181
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 182
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_6

<400> 182
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Lys Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 183
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_7

<400> 183
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Asn Gly Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 184
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_8

<400> 184
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Phe Lys Lys Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 185
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_9

<400> 185
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Tyr Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 186
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_10

<400> 186
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Leu Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 187
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_L3_11

<400> 187
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Phe Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 188
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - CDR-H2 for clone 22D11

<400> 188
Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15
Val Arg Gly


<210> 189

<400> 189
 000

<210> 190
<211> 217
<212> PRT
<213> Homo sapiens

<400> 190
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln
            100                 105                 110
Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu
        115                 120                 125
Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro
    130                 135                 140
Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
145                 150                 155                 160
Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu
                165                 170                 175
Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val
            180                 185                 190
Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln
        195                 200                 205
Lys Ser Leu Ser Leu Ser Pro Gly Lys
    210                 215

<210> 191
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - Anti-BACE VH

<400> 191
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser
 1               5                  10                  15
Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Leu Ser Gly Tyr
            20                  25                  30
Gly Val Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met
        35                  40                  45
Gly Asn Ile Ile Pro Gly Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe
    50                  55                  60
Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr
65                  70                  75                  80
Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Arg Ser Gly Gly Thr Lys Tyr Gly Met Leu Asp Val Trp Gly Gln
            100                 105                 110
Gly Thr Met Val Thr Val Ser Ser
        115                 120

<210> 192
<211> 108
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - Anti-BACE VL

<400> 192
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Val Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Asn
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile
        35                  40                  45
Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Ser
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Leu Ile Leu Trp Pro Pro
                85                  90                  95
Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 193

<400> 193
 000

<210> 194
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC5
      Heavy chain constant domain 1 (CH1)

<400> 194
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80
Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110
Pro


<210> 195
<211> 107
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_ L1_1 light chain
      constant domain (CL)

<400> 195
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
 1               5                  10                  15
Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe
            20                  25                  30
Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln
        35                  40                  45
Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser
    50                  55                  60
Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu
65                  70                  75                  80
Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser
                85                  90                  95
Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105

<210> 196
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_1 light chain

<400> 196
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Asn Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 197
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_2_v2 light chain

<400> 197
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 198
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_ L1_1 light chain

<400> 198
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Ile Asn Asn Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Thr Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 199
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_2_v1 light chain

<400> 199
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 200
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_2_v2

<400> 200
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Gln Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 201
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_1

<400> 201
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Asn Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 202
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_2_v1

<400> 202
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 203
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 20H4_LC_k3_3

<400> 203
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Gln Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 204
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_4

<400> 204
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Glu Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 205
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_5

<400> 205
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Lys Gln
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 206
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_6

<400> 206
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Ala Asn Ile Asn Lys Gln
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 207
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_7

<400> 207
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Ser Asn Tyr
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 208
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_8

<400> 208
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 209
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_9

<400> 209
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Gly Ile Ser Asn Tyr
            20                  25                  30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 210
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_10

<400> 210
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Ser Asn Asp
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 211
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_11

<400> 211
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Ser Asn Gln
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 212
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_12

<400> 212
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Asp Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 213
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_LC_k3_13

<400> 213
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Gln Asn Ile Asn Ala Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Ser Thr Asn Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 214
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence

<220>
<221> VARIANT        
<222> 2-9, 11
<223> Xaa = any amino acid

<400> 214
Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa
 1               5                  10

<210> 215
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence

<220>
<221> VARIANT        
<222> 3
<223> Xaa = S or G

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Q or A

<220>
<221> VARIANT        
<222> 5
<223> Xaa = N, I, or G

<220>
<221> VARIANT        
<222> 6
<223> Xaa = I or N

<220>
<221> VARIANT        
<222> 7
<223> Xaa = N or S

<220>
<221> VARIANT        
<222> 8
<223> Xaa = A, D, N, K, or Q

<220>
<221> VARIANT        
<222> 9
<223> Xaa = N, I, Q, or Y

<220>
<221> VARIANT        
<222> 11
<223> Xaa = D or A

<400> 215
Lys Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa
 1               5                  10

<210> 216
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Q or A

<220>
<221> VARIANT        
<222> 8
<223> Xaa = W, E, or K

<220>
<221> VARIANT        
<222> 9
<223> Xaa = N or Q

<400> 216
Lys Ala Ser Xaa Asn Asn Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 217
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence

<220>
<221> VARIANT        
<222> 4
<223> Xaa = Q or A

<220>
<221> VARIANT        
<222> 8
<223> Xaa = W, E, or K

<220>
<221> VARIANT        
<222> 9
<223> Xaa = N or Q

<400> 217
Lys Ala Ser Xaa Asn Ile Asn Xaa Xaa Leu Asp
 1               5                  10

<210> 218
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4 CDR-L1 consensus
      sequence

<220>
<221> VARIANT        
<222> 5
<223> Xaa = N or G

<220>
<221> VARIANT        
<222> 9
<223> Xaa = Y, R, or Q

<220>
<221> VARIANT        
<222> 11
<223> Xaa = A or D

<400> 218
Lys Ala Ser Gln Xaa Ile Ser Asn Xaa Leu Xaa
 1               5                  10

<210> 219
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC6.1 heavy chain

<400> 219
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Ala Tyr Ala Thr Tyr His Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala
            420                 425                 430
Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 220
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC6.2 heavy chain

<400> 220
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Ser Lys Ala Asn Ala Tyr Ala Thr Ala His Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala
            420                 425                 430
Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 221
<211> 213
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - h20H4_LC_k3_2.1 light chain

<400> 221
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Asp Ala Ser Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160
Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser
                165                 170                 175
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205
Asn Arg Gly Glu Cys
    210

<210> 222
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC6.1_VH

<400> 222
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Ala Tyr Ala Thr Tyr His Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 223
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC6.2_VH

<400> 223
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Ser Lys Ala Asn Ala Tyr Ala Thr Ala His Ala Ala
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 224
<211> 106
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - h20H4_LC_k3_2.1_VL

<400> 224
Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly
 1               5                  10                  15
Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Asn Ile Asn Lys Asn
            20                  25                  30
Leu Asp Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Pro Leu Ile
        35                  40                  45
Tyr Asp Ala Ser Asn Leu Lys Thr Gly Ile Pro Ala Arg Phe Ser Gly
    50                  55                  60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80
Glu Asp Phe Ala Val Tyr Tyr Cys Tyr Gln Tyr Lys Ser Ala Trp Thr
                85                  90                  95
Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105

<210> 225

<400> 225
 000

<210> 226
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC5_LS heavy chain

<400> 226
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala
            420                 425                 430
Leu His Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 227
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - 20H4_HC5 heavy chain

<400> 227
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Leu
        35                  40                  45
Ala Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Val Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 228
<211> 448
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic sequence - h20H4_HC6 heavy chain

<400> 228
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro
        115                 120                 125
Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly
    130                 135                 140
Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn
145                 150                 155                 160
Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln
                165                 170                 175
Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser
            180                 185                 190
Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
        195                 200                 205
Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr
    210                 215                 220
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser
225                 230                 235                 240
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                245                 250                 255
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
            260                 265                 270
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
        275                 280                 285
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
    290                 295                 300
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
305                 310                 315                 320
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                325                 330                 335
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
            340                 345                 350
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
        355                 360                 365
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
    370                 375                 380
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
385                 390                 395                 400
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
                405                 410                 415
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
            420                 425                 430
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
        435                 440                 445

<210> 229
<211> 118
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - h20H4_HC6_VH

<400> 229
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30
Ala Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Leu Val
        35                  40                  45
Ser Arg Ile Arg Thr Lys Pro Asn Asn Tyr Ala Thr Tyr His Ala Asp
    50                  55                  60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr
65                  70                  75                  80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95
Tyr Cys Thr Ala Asp Met Ala Thr Gly Asp Tyr Trp Gly Gln Gly Thr
            100                 105                 110
Leu Val Thr Val Ser Ser
        115

<210> 230
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 9E4 VH

<400> 230
Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Ala
 1               5                  10                  15
Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
            20                  25                  30
Gly Met Ser Trp Val Arg Gln Thr Ser Asp Lys Arg Leu Glu Trp Val
        35                  40                  45
Ala Ser Ile Ser Ser Gly Gly Gly Ser Thr Tyr Tyr Pro Asp Asn Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Glu Asp Ala Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys
                85                  90                  95
Ser Arg Gly Gly Ala Gly Ile Asp Tyr Trp Gly Gln Gly Thr Thr Leu
            100                 105                 110
Thr Val Ser Ser
        115

<210> 231
<211> 113
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - 9E4 VL

<400> 231
Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Val Gly
 1               5                  10                  15
Glu Lys Val Thr Met Ser Cys Lys Ser Ile Gln Thr Leu Leu Tyr Ser
            20                  25                  30
Ser Asn Gln Lys Asn Tyr Leu Ala Trp Phe Gln Gln Lys Pro Gly Gln
        35                  40                  45
Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Ile Arg Lys Ser Gly Val
    50                  55                  60
Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
65                  70                  75                  80
Ile Ser Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln
                85                  90                  95
Tyr Tyr Ser Tyr Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu
            100                 105                 110
Lys


<210> 232
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - aslo452 ngl3 VH

<400> 232
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45
Ser Ser Ile Ser His Leu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95
Ala Gly Gly Ala Asn His Gly Lys Tyr Tyr Tyr Gly Met Asp Lys Trp
            100                 105                 110
Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120

<210> 233
<211> 115
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic seqeunce - aslo452 ngl3 VL

<400> 233
Gln Ala Val Leu Thr Gln Pro Ala Ser Leu Ser Ala Ser Pro Gly Ala
 1               5                  10                  15
Ser Ala Ser Leu Thr Cys Thr Leu Arg Ser Gly Ala Pro Leu Pro Lys
            20                  25                  30
Tyr Arg Ile Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Pro Pro Gln Tyr
        35                  40                  45
Leu Leu Arg Tyr Lys Ser Asp Ala Asp Lys His Gln Gly Ser Gly Val
    50                  55                  60
Pro Ser Arg Phe Ser Gly Ser Lys Asp Ala Ser Ala Asn Ala Gly Ile
65                  70                  75                  80
Leu Leu Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys
                85                  90                  95
Met Val Trp Asp His Gly Val Trp Tyr Phe Gly Gly Gly Thr Lys Leu
            100                 105                 110
Thr Val Leu
        115
