                         SEQUENCE LISTING

<110>  Flexion Therapeutics, Inc.
 
<120>  Effective dosages of an Adenoviral based biological delivery and expression system for 
use in the treatment of osteoarthritis in humans, and compositions comprising the same

<130>  FLEX-011/001WO 311750.2212

<150>  62/966,632
<151>  2020-01-28

<150>  62/902,041 
<151>  2019-09-18

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  535
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  murine Il-1Ra

<400>  1
atggaaatct gctggggacc ctacagtcac ctaatctctc tccttctcat ccttctgttt       60

cattcagagg cagcctgccg cccttctggg aaaagaccct gcaagatgca agccttcaga      120

atctgggata ctaaccagaa gaccttttac ctgagaaaca accagctcat tgctgggtac      180

ttacaaggac caaatatcaa actagaagaa aagatagaca tggtgcctat tgaccttcat      240

agtgtgttct tgggcatcca cgggggcaag ctgtgcctgt cttgtgccaa gtctggagat      300

gatatcaagc tccagctgga ggaagttaac atcactgatc tgagcaagaa caaagaagaa      360

gacaagcgct ttaccttcat ccgctctgag aaaggcccca ccaccagctt tgagtcagct      420

gcctgtccag gatggttcct ctgcacaaca ctagaggctg accgtcctgt gagcctcacc      480

aacacaccgg aagagcccct tatagtcacg aagttctact tccaggaaga ccaat           535


<210>  2
<211>  29612
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  helper-dependent adenoviral vector-murine Il-1Ra gene

<400>  2
aaacatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

ttccgggtca aagttggcgt tttgatatca agcttatcga taccgtaaac aagtctttaa      480

ttcaagcaag actttaacaa gttaaaagga gcttatgggt aggaagtagt gttatgatgt      540

atgggcataa agggttttaa tgggatagtg aaaatgtcta taataatact taaatggctg      600

cccaatcacc tacaggattg atgtaaacat ggaaaaggtc aaaaacttgg gtcactaaaa      660

tagatgatta atggagagga tgaggttgat agttaaatgt agataagtgg tcttattctc      720

aataaaaatg tgaacataag gcgagtttct acaaagatgg acaggactca ttcatgaaac      780

agcaaaaact ggacatttgt tctaatcttt gaagagtatg aaaaattcct attttaaagg      840

taaaacagta actcacagga aataccaacc caacataaaa tcagaaacaa tagtctaaag      900

taataaaaat caaacgtttg cacgatcaaa ttatgaatga aattcactac taaaattcac      960

actgattttg tttcatccac agtgtcaatg ttgtgatgca tttcaattgt gtgacacagg     1020

cagactgtgg atcaaaagtg gtttctggtg cgacttactc tcttgagtat acctgcagtc     1080

ccctttctta agtgtgttaa aaaaaaaggg ggatttcttc aattcgccaa tactctagct     1140

ctccatgtgc tttctaggaa acaagtgtta acccacctta tttgtcaaac ctagctccaa     1200

aggacttttg actccccaca aaccgatgta gctcaagaga gggtatctgt caccagtatg     1260

tatagtgaaa aaagtatccc aagtcccaac agcaattcct aaaaggagtt tatttaaaaa     1320

accacacaca cctgtaaaat aagtatatat cctccaaggt gactagtttt aaaaaaacag     1380

tattggcttt gatgtaaagt actagtgaat atgttagaaa aatctcactg taaccaagtg     1440

aaatgaaagc aagtatggtt tgcagagatt caaagaaaat ataagaaaac ctactgttgc     1500

cactaaaaag aatcatatat taaatatact cacacaatag ctcttcagtc tgataaaatc     1560

tacagtcata ggaatggatc tatcactatt tctattcagt gctttgatgt aatccagcag     1620

gtcagcaaag aatttatagc cccccttgag cacacagagg gctacaatgt gatggcctcc     1680

catctccttc atcacatctc gagcaagacg ttcagtccta cagaaataaa atcaggaatt     1740

taatagaaag tttcatacat taaactttat aacaaacacc tcttagtcat taaacttcca     1800

caccaacctg ggcaatatag tgagacccca tgcctgcaaa aaaaaaaaaa ttagccaggc     1860

atggtagcat gtacctgtag tcccagctac ttgagaggtg aggtgggaaa atcactttag     1920

tgcaggatgt tgaggctgga gtgaactgtg attgtgccac tgcactccag cctggacaat     1980

agagcaagac cttgtctcaa aaaaatgcat taaaaatttt ttttaaatct tccacgtatc     2040

acatcctttg ccctcatgtt tcataaggta aaaaatttga taccttcaaa aaaaccaagc     2100

ataccactat cataattttt tttaaatgca aataaaaaca agataccatt ttcacctatc     2160

agactggcag gttctgatta aatgaaattt tctggataat atacaatatt aagagagact     2220

gtagaaactg ggccagtggc tcatgcctgt aatcccagca ctttgggagg ctgggtaaca     2280

tggcgaaccc tgtttctaca aaataaaaat attagctggg agtggtggcg cacacctata     2340

gtcccagcta ctcaggaggc tgaggtggaa ggatcgcttg aacccaggag gttgagactg     2400

cagtgaactg tgatcattct gctgcactgc accccagcct gggcaacaga gaccttgtct     2460

caaaaaaaaa aaaaaaagag acaaattgtg aagagaaagg tactctcata taacatcagg     2520

agtataaaat gattcaactt cttagaggaa aatttggcaa taccaaaata ttcaataaac     2580

tctttcccct tgacccagaa attccacttg aataaagctg aacaagtacc aaacatgtaa     2640

aagaatgttt cttctagtac agtcggtaag aacaaaatag tgtctatcaa tagtggactg     2700

gttaaatcag ttatggtatc tccataagac agaatgctat gcaaccttta aaatatatta     2760

gatagctcta gacacactaa tattaaaagt gtccaataac atttaaaact atactcatac     2820

gttaaaatat aaatgtatat atgtactttt gcatatagta tacatgcata ggccagtgct     2880

tgagaagaaa tgtgtacaga aggctgaaag gagagaactt tagtcttctt gtttatggcc     2940

tccatagtta gaatatttta taacacaaat attttgatat tataatttta aaataaaaac     3000

acagaatagc cagacataca atgcaagcat tcaataccag gtaaggtttt tcactgtaat     3060

tgacttaaca gaaaattttc aagctagatg tgcataataa taaaaatctg accttgcctt     3120

catgtgattc agccccagtc cattaccctg tttaggactg agaaatgcaa gactctggct     3180

agagttcctt cttccatctc ccttcaatgt ttactttgtt ctggtcccta cagagtccca     3240

ctataccaca actgatacta agtaattagt aaggccctcc tcttttattt ttaataaaga     3300

agattttaga aagcatcagt tatttaataa gttggcctag tttatgttca aatagcaagt     3360

actcagaaca gctgctgatg tttgaaatta acacaagaaa aagtaaaaaa cctcatttta     3420

agatcttact tacctgtcca taattagtcc atgaggaata aacacccttt ccaaatcctc     3480

agcataatga ttaggtatgc aaaataaatc aaggtcataa cctggttcat catcactaat     3540

ctgaaaaaga aatatagctg tttcaatgag agcattacag gatacaaaca tttgattgga     3600

ttaagatgtt aaaaaataac cttagtctat cagagaaatt taggtgtaag atgatattag     3660

taactgttaa ctttgtaggt atgataatga attatgtaag aaaacaacag gccgggcggg     3720

ttggttcaca cgtgtaatcc cagcactttg ggaggctgag gcaggcagac tgcctgagct     3780

caggagttcg agaccagcct gggcaacacg gtgaaatccc gtctctacta aaaatacaaa     3840

aaaattagcc gggtgtggtg acacatgcct gtagtcccag ctacttggga ggctgaggca     3900

ggagaatcac ttgaacctgg gaggtgaagg ttgcagtgag ccaagatggc accacttcac     3960

tccagcctgg gaaacagagc aagactctgt ctctgagctg agatggcacc acttcactcc     4020

agcctgggaa acagagcaag actctgtctc aaaaaaaaca aaacacacaa acaaaaaaac     4080

aggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggtgg     4140

atcacctgag gtcaggagtt ccagaccagc cttgtcaaca tggtgaaacc tccccccgcc     4200

gtctctacta aaaatacaaa aattagccag gcgtggtggc aggagcctgt aatcccagct     4260

acttgggagg ctgaggcagg agaatcgctt gtacccagaa ggcagaggtt gcactgagct     4320

gagatggcac cattgcactc cagcctgggg gacaagagcg agatttcgtc tttaaaaaac     4380

aaaaacaaaa caaaaaacca tgtaactata tgtcttagtc atcttagtca agaatgtaga     4440

agtaaagtga taagatatgg aatttccttt aggtcacaaa gagaaaaaga aaaattttaa     4500

agagctaaga caaacgcagc aaaatcttta tatttaataa tattctaaac atgggtgatg     4560

aacatacggg tattcattat actattctct ccacttttga gtatgtttga aaatttagta     4620

aaacaagttt taacacactg tagtctaaca agataaaata tcacactgaa caggaaaaac     4680

tggcatggtg tggtggctca cacttgtaat cccagtgctt tgggaggctg agacaggaga     4740

gttgcttgag gccaggagtt caagaccgac atggggaatg tagcaagacc ccgtccctac     4800

aaaaaacttt gtaaaaattt gccaggtatg gtggtgcata cctgtagtcc cagctactcg     4860

ggaggcggag gcagaaggaa tcacttgagc ccaggagttt gaggctgcag tgagctacga     4920

tcataccaca gcactccagc gtggacaaca gagtaagacc ctatctcaaa aacaaaacaa     4980

aacaaaacaa acaaaaaaaa ccacaagaaa aactgctggc tgatgcagcg gctcatgcct     5040

gtaatcccag tattttggga ggcccaggtg ggcgtatcac ctgaggtcag gagttagaga     5100

ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaatt agccaggcat     5160

gtggcacgcg cctgtagtcc cagttactgg gaggctgaag caggaggatc acctgagccc     5220

gggaggtgga ggttgcagtg agccgagatc acaccactgc actccagcct gggtgacaca     5280

gcaataccct acctcaaaat aaaaaagaaa aagaaaagaa aagttgctgt ccccgctacc     5340

ccaatcccaa atccaaacag cctctctcat ctcacagtaa gggggaaaaa tcacccaaaa     5400

aagctaagtg atcttttgaa aacccaaact cttagaagtc taagattatt atagtcaact     5460

catgaagtgt catcataaaa gatactctaa tattatttaa gtagaaccac atattggttg     5520

tcttggtatg tctagcccct ggcatacaaa atatttaata acactgatat ggtacctgtg     5580

atgtgaaaat gtactatgag tacagcttta taaatactat atatgtacct atatacagaa     5640

aaaaatacaa caaaatcata aaagcactta tctttgaaag aggagttaca gcaattttat     5700

ttagttcttt attgctttgc tatatattct aaattttttt caatgaatat atatcacttt     5760

taaaaaaatt caatggtctt tcttataaat tatctttggc agcatgcgtt tttatatata     5820

catataaaat gtatgggaaa tttttaaagg atacattaaa ttaaagcaaa atatacaaac     5880

aaaaaatcag aatacaaaaa gataaaaaga ttgggaaggg agggagggag taaggaggaa     5940

gggtgggtgg gtatagagaa atataccaaa taatggtaag aagtggggtc ttgacacttt     6000

ctacactttt tttaaataaa aaaaattttt ttctctctct tttttttttt tagagacgaa     6060

gtctcgctat gttgcccagg ctggtcttga actcctggga tcaagagatc ctcctgcctc     6120

agcctcccaa ggtgcttgga ttacaggtgt gagccaccac gcctggtcac tttctacact     6180

ttaatatata tattttttca ttttcaatgt catttttatt agttaattta taatacccat     6240

tcaccattat attcaaagtc tatttgaaga aataaaccag aaagaatgaa atactctagc     6300

tcacatgcta ttcaatacta aattaccttt caaatcacat tcaagaagct gatgatttaa     6360

gctttggcgg tttccaataa atattggtca aaccataatt aaatctcaat atatcagtta     6420

gtacctattg agcatctcct tttacaacct aagcattgta ttaggtgctt aaatacaagc     6480

agcttgactt ttaatacatt taaaaataca tatttaagac ttaaaatctt atttatggaa     6540

ttcagttata ttttgaggtt tccagtgctg agaaatttga ggtttgtgct gtctttcagt     6600

ccccaaagct cagttctgag ttctcagact ttggtggaac ttcatgtatt gtcaggttgg     6660

cccgtaatac ctgtgggaca acttcagccc ctgtgcacat ggccaggagg ctggttgcaa     6720

acattttcag gtaggtggac caggacatgc ccctggtcat ggccaggtgg aggcatagtg     6780

ctatacagca ggcagaagtc aatattgatt tgtttttaaa gaaacatgta ctactttcat     6840

aagcagaaaa aatttctatt cttgggggaa aagattatgc cagatcctct aggattaaat     6900

gctgatgcat ctgctaaacc ttcacatatc agaacatatt tactatagaa agaatgaaaa     6960

tgggacattt gtgtgtcacc tatgtgaaca ttccaaaaat attttacaac aactaagtat     7020

tttataaatt ttatgaactg aaatttagtt caagttctag gaaaatacaa accttgctag     7080

atattataaa aatgatacaa tatatattca tttcaggctc atcagaatat atctgttatc     7140

acttgacaag aatgaaaatg caccattttg tagtgcttta aaatcaggaa gatccagagt     7200

actaaaaatg acttcttcct tgaagcttac tcaccaactt cctcccagtt actcactgct     7260

tctgccacaa gcataaacta ggacccagcc agaactccct tgaaatatac acttgcaacg     7320

attactgcat ctatcaaaat ggttcagtgc ctggctacag gttctgcaga tcgactaaga     7380

atttgaaaag tcttgtttat ttcaaaggaa gcccatgtga attctgccca gagttcatcc     7440

cagatatgca gtctaagaat acagacagat cagcagagat gtattctaaa acaggaattc     7500

tggcaatata acaaattgat ttccaatcaa aacagattta cataccatac ttatgtcaag     7560

aagttgtttt gttttattgc atcctagatt ttattttttt gatttatggt ttactttaag     7620

cataaaaaat ttgtcaatac aactcttccc aaaaggcata aacaaaaatt cataaaactt     7680

gcatcacttg agatacttca ggtatgaatt cacaactttg ttacaactta ctatatatat     7740

gcacacatat atatatattt gggtatattg ggggggttct aatttaagaa atgcataatt     7800

ggctatagac agacagttgt cagaacttgg caatgggtac gtgcaggttc attataccaa     7860

gtctacttgt agttgttcaa aatgtatcat aatacaaggc cgggcgaggt cgtcacgcct     7920

gtaatcccag cattttggga ggctaaggca ggaggattgc ttgaggtcag gagtttgtga     7980

ccagcctggg caacagagca agaccctgtc tccaaaaaga aaaaaaataa ttttttacaa     8040

aataaaaaca aaatgtatca tcagacgaaa ttaaataaga ggcaattcat ttaaatgaca     8100

acttttccca gcttgacatt taacaaaaag tctaagtcct cttaattcat atttaatgat     8160

caaatatcaa atactaattt tttttttttt tttttttttg agacggagtc tcgctctgtc     8220

gcccaggctg gagtgcagtg gcgcgatcct ggctcactgc aagctccgcc tcccgggttc     8280

acgccattct cctgcctcag cctcccgagt agctgggatt acagacatgc gccaccacgc     8340

ccggctaatt ttgtattttt agtagagatg gggtttctcc atgttggtca ggctggtctt     8400

gaatttccca cctcaggtga tctgcctgcc tcagcctcac aaagcagtag ctgggactac     8460

aggcacccac caccacactt ggttaattct tttgtatttt ttttgtaaag acgggatttc     8520

accatgttag ccaggatggt ctcgatctcc tgatctcatg atccgcccgc ctcagcctcc     8580

caaagtgctg ggattacagg cgtgagccac cccgcccggc catcaaatac taattcttaa     8640

atggtaagga cccactattc agaacctgta tccttatcac taatatgcaa atatttattg     8700

aatacttact atgtcatgca tactagagag agttagataa atttgataca gctaccctca     8760

cagaacttac agtgtaatag atggcatgac atgtacatga gtaactgtga acagtgttaa     8820

attgctattt aaaaaaaaag acggctgggc gctgtggctc atgcctgtaa tcccagcact     8880

ttgggaggcc aaggcaagtt gatcgctcga ggtcaagagt tcgagaccag cctggccaac     8940

gtggtaaaac cccgtctcta ctaaaaatac aaaaaaaaaa ttagccaggc atggtggcac     9000

aggcctgtaa tcccagctac tagggaggct gagacatgga gaactgcttg aatccaggag     9060

gcagaggtta cagtgagccg agatcatacc actacactcc agcctgagtg acagagcgag     9120

actcctgtct aaaaaaaaaa aaaaaaaaaa agatacaggt taagtgttat ggtagttgaa     9180

gagagaactc aaactctgtc tcagaagcct cacttgcatg tggaccactg atatgaaata     9240

atataaatag gtataattca ataaatagga acttcagttt taatcatccc aaacaccaaa     9300

acttcctatc aaacaggtcc aataaactca atctctataa gagctagaca gaaatctact     9360

tggtggccta taatcttatt agcccttact tgtcccatct gatattaatt aaccccatct     9420

aatatggatt agttaacaat ccagtggctg ctttgacagg aacagttgga gagagttggg     9480

gattgcaaca tattcaatta tacaaaaatg cattcagcat ctaccttgat taaggcagtg     9540

tgcaacagaa tttgcaggag agtaaaagaa tgattataaa tttacaaccc ttaaagagct     9600

atagctgggc gtggtggctc atgcctgtaa atcccagcac tttgggaggc tgaggcgggt     9660

ggatcacctg aggccagaag ttcaagacca gcctagccaa catggcgaaa ccctgtctct     9720

acaaaaaata caaaaattag ccgggtgtgg tggcacgtgc ctgtagtccc agttacttgg     9780

gaggccgagg caggagaatc gcttgaacct aggaggtgga ggctgcagtg agccgagatt     9840

gtgccactgc actccacttc agcctgggcg acaagagcaa gactccgtca caaaaaaaaa     9900

aaaaaaaaaa aagcttaaaa tctagtggga aaggcatata tacatacaac taactgtata     9960

gcataataaa gctcataatc tgtaacaaaa tctaattcga caagcccaga aacttgtgat    10020

ttaccaaaaa cagttatata tacacaaaaa gtaaacctag aacccaaagt tacccagcac    10080

caatgattct ctccctaagc agtatcaagt ttaaagcagt gattacattc tactgcctag    10140

attgtaaact gagtaaagga gaccagcacc tttctgctac tgaactagca cagccgtgta    10200

aaccaacaag gcaatggcag tgcccaactt tctgtatgaa tataagttac atctgtttta    10260

ttatttgtga cttggtgttg catgtggtta ttatcaacac cttctgaaag aacaactacc    10320

tgctcaggct gccataacaa aataccacag actgagtgac ttaacagaaa cttatttctc    10380

acagttttgg aggctgggaa gtccaaaatt aaggtacctg caaggtaggt ttcaatctca    10440

ggcctcttct ttggcttgaa ggtcttctaa ctgtgtgctc acatgacctc ttctaacaag    10500

ctctctggtg tctctttttt tttttttttc ttttttgaga cagagtctca ctctgtcacc    10560

caggctggag tacagtggca caatctgggc tcactgcaac ctccaactcc cgggttcaag    10620

tgattctcat gcctcaccct cccgagtagc ttggatgaca ggagcccgct accacaccca    10680

gctaattttt gtatttttag tagagatggt gtttcactac attggccagg ctggtctcaa    10740

actcctgacc tcgtgatcca cccaccttgg cctcccaaag tgctgggatt acaggtgtga    10800

gccactgcgc ccgtcctggt gtcttttcat ataagggcac taatccaatc agacctgggc    10860

ccaaccctcc cgacttcttc taactgtaat taccttccaa aggccctgtc tccaaatacc    10920

atcacactgg gggttaggac ttcaaaaaag gtatgggggg ggtgtgggag gacataaatg    10980

ctcagtccat aacaagcacc caacataaaa atggctagaa cagatcacaa aaaaaaggtc    11040

ctgtatggct ttggggaagg gctcaacccc aaaatatctg agagctctgg aggggcctag    11100

aagtggtaaa tgaatgaaaa cgtggttact ctccagatct gcctttccca aatatggcca    11160

ttcttggctg aatcagaaat caaaggacag gttattaatt actagctcta agttacttac    11220

catttgctga gacagttcag aaatctgact gcatctcctc agagatctag aacacagttc    11280

tcaaattcta acttacttgt gatatacttg tgaatgataa aaatcgctac aggtactttt    11340

attaatctga aagagtattg agaaattacc tttcattctg acttttgtct ggaatgaaaa    11400

tcaatacttt tgctataatc gattactgaa ataattttac tttccagtaa aactggcatt    11460

ataatttttt ttaattttta aaacttcata attttttgcc agactgaccc atgtaaacat    11520

acaaattact aataattatg cacgtcacat ctgtaataat ggccttcatg taaacatttt    11580

tgtggtttac acataaaatc tctaattaca aagctatatt atctaaaatt acagtaagca    11640

agaaaattaa tccaagctaa gacaatactt gcaacatcaa ttcatcatct gtgacaagga    11700

ctgcttaagt ctctttgtgg ttaaaaagga aaaaaaaaaa aaagacatgt tggccagatg    11760

cggtggctca cacctgtaat cccagcactt tgggaggctg aggtgggcgg atcacccctg    11820

gcctgcccaa catggtgaaa ccccgtctct actaaaaaca caaaaattag ctgggcgtgg    11880

tggcgggcgc ctgtaattcc agctactcgg gaggctgagg caggagaatt gctagaaccc    11940

aggaggcaga gattgcagtg agctgagatt gcaccattgc actacagtct gggcaacaaa    12000

agtgaaactc catcttaaaa aaaaaaagac aatgttcgtg ggtccaaaca agacttaatg    12060

gaagtgagtc taaaaatgag ctatgtgggc caggcgtagt ggctcccacc tgtaatccca    12120

gcactttggg aggccgaagc aggcagatca tgaggtcagg agatggagac catcctggcc    12180

aacacggtga aatcctgtct ctacaaaaat tagctgggcg tggtggtgcc tgcctgtaat    12240

cccagctact cagaaggctc aggcaggaga atcgcttgaa ccagggagtc ggtggctaga    12300

gtgagccgag atttgcatca ctgcactcct gcctggtgac agagcaagac tccatctcaa    12360

aaaaaacaaa caaaaataaa agataaaaat gagctatgtg aattaaaaga ggtataacaa    12420

tagataaacc atattttatt taattcctag taatgagtaa tatttccaaa cttctggaat    12480

gggcagaaat tgctagttgg catattttta ccttttatat tcagatacat taaaattctc    12540

aaaaaaaaac acctcaaagc agatgatccg ccatctcctt ggataatttg tgttaactca    12600

ggataacaga aaaccaaaat tatgagttac tgatgcaata ttcctaaatg taaaaataat    12660

taaagctaat agtagattca tcttccaatt tcatatcagt cttacaaata aactacatat    12720

ataacttgct tgccttccct tctgagggat aaagctgtta gaagaattaa aatcagcatt    12780

cttgactatt caaccaaggg agggataaat tattactcat tctagggaca tgggctcata    12840

actactacat gtgtaaggac atgaatttac ccaatattac aatttttcct tttattagtg    12900

tgtacagtgg aagaatagac atgttcactc tggacaaaaa aaaaattata cttatcagtt    12960

atcagaagca caatgctgaa gacagtagtt ccataacaat ttgaagtatg tgatcgaact    13020

agtagattat cttagtagta gtgaattatt gtaaatgtta gtaatttggc agccactggg    13080

cagaaaaata agaattgagg ctcaatattg atattaatgg tggtgattga cacataaatt    13140

ttatcaagtc tacacaatat aaaattacag aaaggtagaa gagtatacca gtacaacttc    13200

aacatatctt cactacaagg gagtaaaatg acatggccta gttactatct aatgaactgc    13260

agaaaactaa aagaaaactc caaggcaact cttctctgct gatctggttg gtccttttcc    13320

taccttttgc aatacccaga tacaaacaat ggatagaaaa caaagtagac ttgtagtatg    13380

caggtcacag tgctaaattc acagaaagaa acccctgaac tgaactgctc tatttcctgg    13440

tggtcacaaa gagtaattct ggtttacacc tacagattga tgtcaatcta caccctgttg    13500

ataacagtgt ggccaaggac aaaaaaaagg tgctccgttt taccaattct gtaaaaaatt    13560

attggcaggg taagctcggc tagggcagga ttacatttct aggactacca tccccgaaat    13620

ttagaagata ttatatccac ataaagcata tctttcacat taatttgcaa aaatctaaaa    13680

gctttttctt agctcaagtg tgtccaagtt taccctggca gtttaaaacg atagttacaa    13740

gcagcatggg ttgtatcaga cacatttgag ggccaatttc atgtaagtga tattgggcaa    13800

gttacttcaa ctatctgtgc ctccaaggtc atactagtgt ttatttacct aaagggtacc    13860

tgttatgtaa ctttagggtg tttacattag ataatgcctg caaaatattt acttcaacgc    13920

ctaaaacata gttaagtatt caataaatac ctactattgt cactactaac ttaaaagttt    13980

agagattaag agcagaatct ggggtgagac aaacttaggt tcaaatccta gtattgttgg    14040

gtaatcttgg gcaagttact taacctctct gatttgtgta atttaaaaaa ttagttaata    14100

tacataacag ggcttagaag agtatctagc acatagcacc atttaagcat ttgttattgc    14160

taacatgcaa acaatttaag ggaaagaaat tttttaaaaa ggaagaggga tttgcaaact    14220

aaaaacaatg agtatcttat gttcaaagaa aactaacaaa cagccagctc tagcaataat    14280

taaattcact atatactggg gcaggcatca caccccaaag ctaaaagcgt ctacctaggc    14340

caggcacggt ggctcatgcc tgtaatccca gcactttggg aagcagaggc gggcagatcg    14400

cttgagctca ggagttcaag accagcctgg acaacatggc aaaacaccat ctctacaaaa    14460

aatacaaata ttaggccggg cgcagtggct cacgcctgta atcccagcac tttgggaggc    14520

caaggcgggt ggatcacctg agatcaggag ttcgagagta gcctggccaa catggtgaaa    14580

cctcgtctct attaaaaata caaaaaatta gccaggcatg gtggcaggcg cctgtaatcc    14640

cagctactca gggggatgag gtaggagaat cgcttgaacc cgggaggcag aggttgcact    14700

gagccgagat catgccactg tactccagcc cgggcaacaa gagcgaaact ccatctcaaa    14760

aaataaataa ataaataaat aaaataaagt acaaatatta gccagggatg gtggtgcgca    14820

cctgtagtcc cagctacttg ggaggctgaa gtgggagaat cccctgagcc tggggagaat    14880

cacccgagcc cgggaagtcg aggctgcagt gagcagtgat tgtgccactg cactccatcc    14940

taggtgacag agtgagaccc tgtctcaaaa aaaagaaatt ggcagaatta agtaagttga    15000

tgtttagaga tgaaaaatca acattttttc ctcagcaact gaataaaaac aacagccact    15060

accatttttt tgagtaccta tttgtagcct attttttaac tggtattact cgagagagag    15120

agagctaggt tcgagacaga gctccttctc ttaataactg tatgacctag ggtatgtctg    15180

ttagcctctc tgaggcttca aaggttcctc atctgtaaaa tggtaataat cataccattg    15240

ctacagggct gttttgaaga ctaattagga ctatgtaagt aaacatgatg atggctatta    15300

ttactgttcc ccgccagggg ccatgcaagg gttgctgatt cacatagact gtcttataat    15360

cctctcaata actccaagag gtagccagca cctcagatat acataaaatg acttaagccc    15420

agagaggtga agtaagttgc ccacagccac acaactagta aatagcccaa acaagctgga    15480

ttcccagtta gactccgtta atagcactgc tctttacctt aagtcattac aatgcctaat    15540

atgaaataga atcgcttctt tcttagggtt caagtggtta attatttaat gtattcattc    15600

aacaaaccat catcgaggac ctcttacaag ccaagtactg tgctaagtgc tagagttacg    15660

gcggtgattc ctgcccttaa aaagttttag tgggagaaac aacaggtaac caggtcattg    15720

ccaaaacaac aaaaataatc ataataaagc aggctaaagc atatttaact ggccggggtt    15780

ttgactattt tagcaagcat gatcagaacg gttgaggagg gaggccagca gcttggccgg    15840

ttcaacaaac aagaaaaaac cagtgagggt ggagctaaga taccagaggc tgattacggt    15900

taagaatgtt cttgaaggta aggaccagat tctcattttc tatatcctgg ggcatcggtc    15960

agcatggaat ctggattcta gcacatgtga atttcggctt gaaatgacct aatgcctttt    16020

ccctagttcc ttcgtgtgtc aaatacgcat ggttaccgct accagagctg tagtggggct    16080

tcaatgaggc catgagcatc tccataaaga tgaactacag tgtgtgcaaa actaaaggca    16140

aaacctggtc cccacacgcc ctcccaggtg gtcgctttcc gtgccgaggc ccctccagag    16200

gtgccccgag aacctcacca tcgcacccca aacttccagg gaagggcctc tcccgagaaa    16260

gcccccacgc ccccaccccg cgccatcatt cccgaatctg ccctcggccc ctccccgcag    16320

cacgctcgca ggcggcacat gtcaaccaaa acgccatttc caccttctct tcccacacgc    16380

agtcctcttt tcccagggct cccccgagga gggacccacc ccaaaccccg ccattccgtc    16440

ctccctgccg ccctcgcgtg acgtaaagcc gaacccggga aactggccgc ccccgcctgc    16500

ggggttccct gggcccggcc gctctagaac tagtggatcc caattgaagg cctggtctaa    16560

atgactccaa aatcaccact taattcaaga gactgatttc cctgagtcag gccccttaaa    16620

gcagctattt caatgggaca gggaaacaac cctaggatct ggattagaat cacttggggg    16680

ctgccacacc cccagggctc tgatcctgcc cttctcccac acgcacattc acatactgct    16740

gcagtgacct tccatttcta atgggttcct gggccatctg tcaggtatag ggaatggaaa    16800

aggggttggg gaggctctgc ttcagaaagt ttgtgtcagg ggctcccaga gcctccacag    16860

atagatagca ggggtcccca ccctaccatg gcagctataa atgtgatcaa catttattgg    16920

cctaggatac agcagttagc aaaatgcctg atgtagttcc cactccgtgg aggttgcagg    16980

ctagccaaga agtcatgagt tcagcaaccc ttacgcacca gtgggatgag attggaccag    17040

gccgagggta gtcttgggaa cactcagcat ttgtctgagg gccagaagag gctgcttgcc    17100

ctcagacagg aggtcagcat ctttattgta gcccatgaca cctctacacc attgctcttc    17160

tggtcttatg gaagacatct ttgggcctga taacagcgga gtctgtgtcc cacttgtcca    17220

ggctggagtg ccacatcagg cacactccag ttgcagggac agcacagaca agtttcagga    17280

aggctggtgg cctccaggag gttaacctta taaggccaga ttgtaaccta gttgaaaaac    17340

atacacatgc catgataata aaagaaccta ggcaccatta caagagaaaa aatcattttt    17400

gtagatacga gcatggattc ttgggtgggt cagacacact gggcttgtgc tctgactgca    17460

ctgtctcccc tacctgacct tgggtaaacc ataagactgc tgcatgactc agtgtccacc    17520

ccaaaaaagt accggtagat attggccaca gtagatatca gctagagtgg actctcatga    17580

caatgagggg agatgtattc cccatcttag gcacctggga ctctaccttc catcttctgc    17640

tccgtgtctc tccatcccca ggctcttcag aactcaggga gtccagaatg tcagctccca    17700

gatttcagcc ttcagaaagg aaacccatta ccgttcagtt gaacaaatgt tgtctgagcc    17760

ccagatctgg gctcagaggc catctaggct atgagacaag aggggaacaa agcaccgtct    17820

gcactcactc accacactca cttgctgtcc caggtcacat ccatcgggta gagaatctaa    17880

gaggctgagc tagctcccgc caccagccca gcccacccca cctggcccct tccttccttc    17940

tacaaaatat gcaccacctg tcaaagggtg ggcagtgcca ggcctgcata cagagcactg    18000

agtgtaaaag cagacatgga ccctgacctc caggagcttc caattttctt gaagagacaa    18060

atcagctggc atttcagtcc agtgtgatct gctcttggtg agcacagacc tagggagttg    18120

gggcagcttc ccagaagaac tgcagtccag gctgagggca gagaaatgag gggaatggcg    18180

aggaattggg gagcaggggg gagctcagta gagagccaag ggcgggaggt gagaagtccg    18240

tgttgggcca ggagctaccc tccggtggcc acagccgaag tcgaggatgc ctttggaact    18300

catccccact tctctctttc tgtatgtagc cgtccaagaa caagtcacct ccaagtgtag    18360

ccggatcaag gcaagccccc catctagcaa gcacttgatg ccacccagaa ctgggcttct    18420

tcagaacaat ctgagtccag gaatgatccc actcaccagg caccagagct gcgagggcat    18480

gggagtgatc tcaccaactc tggggaagcg gcaaggaatt ttcacctcca gcccccagtg    18540

tcccatcctc tcacactcag gccagactcc cctgggcaga cttgactctg tctgccagca    18600

tatgcagagc cccaaggcca ccccaccaga agtgcccctg cctgggttct gtcccagctc    18660

cctgggcacc cagtccttga gtccccacca gctcagacgg cctagtgtgc caagaatgcc    18720

cactgcgttc aacaatgctg catgggtcac agcggcagca gctgtgacca cagcagtttc    18780

ggggaaaaca cccctcagcc aagtggataa tagcgttcag cagcactcac cttctggcca    18840

ggcctgcctt cagaggccat ctgattggga ggcacaagtg cccgctgcga tgggaacaca    18900

agtgcccctg gccaacaacc ccagcttcag cctgctgggc agccagagcc tcaggcagag    18960

cccggtacag ggcccggtgc ctgtagcaaa caccaccaag ttcctccagc agggtatggc    19020

cagctttagt cccctgagcc ccatacaggg catcgagcca ccaagctatg tggctgctgc    19080

tgccaccgct gctgctgctt ctgccgttgc tgccagccag ttcccaggtc cgttcgacag    19140

aacggatatt ccccctgagc tgccacctgc cgactttttg cgccagcccc aacccccact    19200

aaatgatctg atttcgtcac ctgactgcaa tgaggtagat ttcattgaag ctctcttgaa    19260

aggctcctgt gtgagcccag atgaagactg ggtgtgcaac ttgaggctga tcgacgacat    19320

tttggaacag catgctgctg ctcaaaatgc cacagcccag aattctgggc aagtcaccca    19380

ggatgctggg gcactttaaa tctgagcagg atgcccatag aaacccccat ggtgacatca    19440

ctctaggaag tggtgtcgat ccatacccgc agttgtctcc cgttacaatt tgagtggtgt    19500

tgtcagccca tgcttatccc tctctctacc tgtgacaaaa tggaaagctg gtgatttttc    19560

aagctacgtg tacatatttg aaaattttgt aaatggtttt cctaaacatt aatgacagaa    19620

gtatttatac ttcattttgt gactttgtaa ataaagcgac ggcttttgtt tcagtagagt    19680

tgtgtttact atgcattgtt ttgtgtttat tatacaatgt tacaaatatg cagaccgtgt    19740

tgtttgctcc agtgatacct tgttaagcta ggtggctgag tcgcttatgg ttttaatgca    19800

atgagcaatg tggatatgac caagagttgt tgtgcaagtt gacaaatgcc aaatagaaaa    19860

ccacttggcc atttatttct atgttcacta aaaatcctat tgccttgtgt gattcttaat    19920

ctcttttgcg aacctttcag tctccgctag ctctttccta atgagcttta cagcagaagc    19980

tgttttatcg ttaagtgccc cacagagaca ctttaccagg aggctgggag agttctccag    20040

atttgggaga ggcgcagaga cagtgtgtga gccgagccct gtctcagcaa tccacctgga    20100

ggagctagag tatcctcctc cctttaccat tcagaccgag agaaaaagcc cagcttgtgt    20160

gcaccctcgt ggggttaagg cgagctgttc ctggtttaaa gcctttcagt atttgttttg    20220

atgtaaggct ctgtggtttg ggggggaaca tctgtaaaca ttattagttg atttggggtt    20280

tgtctttgat ggtttctatc tgcaattatc gtcatgtata tttaagtgtc tgttatagaa    20340

aacccacacc cactgtcctg taaacttttc tcagtgtcca gactttctgt aatcacattt    20400

taattgccac ctcgtatttc acctctacat ttgaaatctg gcgtctgttt caagccagtg    20460

tgttttttct tcgttctgta ataaacagcc aggagaaaag tgcctctatg tttttatttt    20520

tcaagggagt attcagtacc tacaaaccca agtcaggaag cctgctagtg gctttggttc    20580

tttcagaggc tgctcgatgc cttgtgtgtc agaaagaaag attcagcagt tttgcatcat    20640

ggcaaagaag cctgttattt tggggctcag cccctcattt tatagaggat gaaacagagg    20700

gggatgggag gtcacaaaga caactgcccc gggagcaggt gtgggggaga cttgccctga    20760

gggtctagac gctctgcacc accgtcctgt ctcccttgct gaagaccaca catgcccttc    20820

tttgaccaga ccctgccacc tgataggcca ggacctggta ggcgggtacc caggtttcat    20880

ggatggaacc acatctcccc aaaagtgggg aggtagctac tgggatgcac gcctcccgcc    20940

atgtgctata ggagagcagc tgaagcaaca gttgggatca gatgtagtca caattgaatg    21000

catcatcaca tttatccctc taagtggctg ggagagttga tatcctcatc cctaaggtac    21060

aaaatgttcc aatttgatca gtggctttca ggagctgaga aaggcatgtg ctctgaggca    21120

gagctgttat gtcccgcaga gcctaaaaat gctctaagaa catgctccct gccaaaattc    21180

tcaatggctg tgacaaggga caacgatcga ccaatggggg tggaagcaga cctccgcagt    21240

ccaggggcca gagctaggac agaggggtcg gagaaagagt cattttccca acactccagc    21300

tcttggccag tcctcacaca gtcccctcct gcttcctgct gagagagata tcctcatagg    21360

tctgggtaaa gtccttcagt cagctttcat tccctgtcac caactttgtc tctgttctcc    21420

ctgcccgtct caggcagcac tcctcaggaa acctctccaa gagccagcct cactgcagcg    21480

cccactattg tccctctgcc tcaagtgtcc catccatgcc aggccccagg caggctgcag    21540

ctttccctca gggccacacc aaagcacttg ggctcagctg tgctgtcccc ctccatcact    21600

gagctcaggg gcagcagggg tggggtgcca ggaggcccat tcacccttct ctggctctgt    21660

gttggaccca cctgcccagc cactgctgct tagaacctac ccgctgggaa aatgaagccc    21720

tcccggaggg gccacctcaa cctgagagcc tcacggatca cagttgtccc cactcagctc    21780

tgccagccct cagagaccca tagataaaag ctgagcttgg ctcgcagagc tggttccatc    21840

ttccattccc agagggttca acttcctacc ccaaccacac agggaacctc aaggctgagc    21900

cagtgtgggc tgcagtgcag accagcttcc tggacacgtc ctgccacctg accccaggct    21960

ggcctcactg cccctggcac tcctgaccct atcctcattc ctcctggcag tgcgtgttct    22020

gccattccgc tttcccttag ctgtcctctc actgtactgt cagcttctcc ttttccaggt    22080

gccccccagg ggctttccac atgaccctgt caccccacag cccatccagc accaattcca    22140

gctctctgcc acccttcaaa ggagtgacag tgccctgctt cacctcccac tcacccctca    22200

acccagagca atctggctcc agtcttgcct ccttccccct aagtactcta gtcacagttc    22260

caaattcctc ctggtcataa agccaaatga agcttcctgg tcctcagcgg acttgccact    22320

tcagcagtac tggactctct cctcccagaa acctgtttcc ccttggctcc tggagcccac    22380

actctgctgg aatccttctg cctctctggc ctgtagcctg gccctctctc ccaacctgag    22440

gtccattctc tcctgctcct ccacaagatg ttgctccttc cattacttcc tccctctcaa    22500

ccaaagctcc ttcattagct ctttatcttc tggtttcttc ccctgggcag acgaatggat    22560

tcaagagcct gtggcccagc agcccagcac tccaggatct cagcacttca gcatcccagt    22620

accctagcat ctcaataccc cagcacccca gcaccatagt attccagcac cccattgtcc    22680

aagcatctca gcactccagc atcccagcac cccaacactc cagcagccca gaatctcagc    22740

accctagcac tgcagcatct caggacccca gcacttcagc atcccagcac actagtactc    22800

cagcatctcg gcaccccagc acctaggcat cccaacaccc agcaccccag cacttaagca    22860

tcccaccact acagtatctc aacactccag caccccagca ccatagtgtt ccagcacccc    22920

agcatcccaa caccccagca cttaagcatc ccaacacctc ggcatcccaa caccccagca    22980

ctgcagcatc tcagcacctt agcatcccag tgccctagca tctcaatgct ccagcacacc    23040

agtactacag tattccagca ccccagcact ccagcatctc agcactgcag cactgcagca    23100

ctccagcatc ccaaaatccc agcatcccaa caccccagca gaccagcaga ccagcatctc    23160

agcaccgcag catccaagga ctatcccagc atcccagcaa cccagcacct cagcatccca    23220

acaccccagc atttcagcat ggcaacaccc cagtacccca gcacttcagc accccagtat    23280

cccagcatct cagcgaccca gtatcacaaa acctcagcat cctagcaccc cagcacccca    23340

gcaccttagc accttagcat cccagcatct cagcgcctca gcatcttgat attctggctg    23400

aggtcagcgt ggtgtatcta gtcagggtcc taactttcac ttcgcaggga aatgctgctg    23460

gactgggtct catgttgggc tgaagctctc tagacccctt gaagacagca taaaagagct    23520

tggagacgct gggtgtcccc catggaagag ttcactctca tcctgctttg acaacagcct    23580

tctctggggt ccctcacggg cccctctttc ttactgcaag tttgtctctg agaagactgt    23640

gatgcagaag tcactcagct gcctgtggct cctgaagagc tgaaggtgga ggcctgtagg    23700

cctccctatg agaggcgcag aaaaaaccat gattgctagt ggggaggtgc tccctctaca    23760

acccactcca taatctgccc ccgcccagct ctgaggccag ccccagggga aaatgccaga    23820

tccccaggga ggtgtgtgag acctcagggg ctccctcctc ccttacagca ggctcaggcc    23880

cctgggggcc tcagggccaa ggtctgtggg taagctacta tctctcactt gtcctctagc    23940

cacaaaagcc agggagatct ggcaatggac atgaggttct gaagaagcac atatgactgg    24000

cttcctaatg cgtggttgtt cagtgattca ataaacacgc atgggccagg catggggaaa    24060

tagacaaaca tgatccccaa cctctcccag agtgaactgg gagggaggag tgttcatccc    24120

tcaggattac accagagaaa caaaccagca ggagatatat atggttttgg ggggtcaaga    24180

aagaggaaaa acctggcaag gcaagtccaa aatcatagga caggctgtca ggaagggcag    24240

cctggaacct ctcaagcagg agctgatgct gcagtccaca ggcagaattt cttcttcctc    24300

ggggaaatct cagctttgtt cttaaggcct ttcaactgat tggctgaggt ctgccccttc    24360

ccccacattc tccaggataa tcttccttac ttaaagtcaa ctattaatca cagctacaaa    24420

atcccttcac agctacacat agatcagtgt ttgattgacg aacagcccct acagcctagc    24480

caagttgaca cataaaacta accatcacag ggggacaaat gatgtaaaca catcaacaaa    24540

taaaacagta acaagttaag gtctatggaa aaaacacaga aggggcagag agaaagaaag    24600

caagaaggag agtcccagtt tgctagggct tgtgggaagt ggggagcagt tctctttagc    24660

taggatattt gggaaaggca tatctgaagg agtgatattt gagcttagat taaaagatgg    24720

gaaggagcaa gccatgcaaa gagctaggat gttccaagca gagacggaac agcaagtgca    24780

aatgtcagga ggaatagaag gaggctggtg ggtggggtcc agtgagcaag aggagggcag    24840

gcaggagagg ggatggggag gtgggcaggc ccagaccacc cagggccctg gagactatcc    24900

tgatccaaca agggaagcct tgagtcactt cagtgtccat gtggagaatg gacctcagac    24960

tgaatgaggg aggcagtaag gagggcctct acctccaggg cttcgccctg tggactgcgc    25020

atagacatct ccaactcaga aagtctgaac caaactttcc atagttcccc caagtctggg    25080

catcctccta ctcagtgaaa ggcagccatc acacctccct gccctgctcc cggatgcccc    25140

aaatcctctt ggtctccaag tccagaacct gagacttgtc cttgatgttt gtctttccct    25200

caccctttct gtattctggg aagatgggtt tttttccccc agatgaatct gtaaaacttc    25260

tgtgatcaca ataaaaattc tggcagtatt attttctgga acatgacaaa gtgattcaaa    25320

attatttatc tggaagacta caaaacaaga atagccagga aatttctaaa aagaaagaag    25380

aaggaggagg agaaagaagg aggaggaaaa ggaggagaag aagaaaagaa aaagaaccaa    25440

gaaagggttc tagctctacc aaatattaaa acatatcatg aagctattta aaacaatatg    25500

gttgtggata ctgaaaaaga tgtgaataaa gtggaaggaa aataaataga aatgcacatg    25560

gggattgaga ctgtgaaaaa ggcagcatct cacatcagtg agggatgttc aacacctggt    25620

gttgggaaaa ctggctagtc atttaaacca aacaactggg tcctctacct cactcctgac    25680

attaagatac atttagatga ttcaaagagt aagacagaaa aaataacacg tgaaaacact    25740

atcagaaaac aacgtgggcc aggtgtggtg ggtcacgcct gtaatcccag cactttggga    25800

ggccgaggca gacagatcac ctgaggtggg gagttcaaga ccagcctgac caacatggtg    25860

aaatcctgtc tctactaaaa atacaaaatt agctgagcgt ggtggcgcat gcctgtaatc    25920

ccagctactc aggaggccga ggcaggagaa tcacttgaac ctgggaggca gaggttgtgg    25980

tgagccgaga tcacgccatt gcactccagc ctgggcaaca agagtgaaaa tccatctaaa    26040

aaaaaaaaaa aaagccaagg tggatatttt tatagtatca gggtagatca agcttctcca    26100

atcatgacat gaaacccaga aaccataaaa gaaaagaatg ataaaattgc ccacgtaaag    26160

taaaaagctt gcacacagaa aaacaccata caggttacaa gatgagcagc aaaatcagag    26220

aaaaaacatt gcaattcagg acacacagag gctattgttc ctaatattta aaaataaaag    26280

tagtggattg tctacaaaaa gatgaagaca agaatttcag aaaaccaaat actgcatgtt    26340

ttcacttaca agtggaagct aaacactgag tacacgtgta cacaaagaat ggaaccatag    26400

gccaggcacc gtggctcacg cctgtaatcc cagtactttg cgaggccgaa gcgggcggat    26460

cacctgaggt gaggagttcg agaccatcct ggccaacatg gtgaaaccca gtctctacta    26520

aaaatacaaa aattagccgg gcgtggtggt gggtgcctgt aatcccagct actcgggagg    26580

ctgcggcagt agaatcgctt gaaccctgga ggtggacctt gcagtgagcc gagatcgcac    26640

cactgcactc cagcctgggc aacagagtga gactccatct caaaaaaaaa aaaaaggaat    26700

agaacaatag acactggggc ctacttgagg gaggagggtg aggatcaaaa acctgcctat    26760

caggtactat gcttattacc tgggtggtga aataatctgt acaccaaacc ccagtgacat    26820

gcaatttacc gatgtaacaa acctgcccat gtacccgctg aacctaaaat aaaagttgga    26880

aaaaaatata gaaattttct ttgtaatagc caaaaactgc aaacagccca ggtgtctatt    26940

agtagaatgc ataaacaaac tcgggcatgt tcatacaatg taaaactact catcaataaa    27000

aagtgatact tctcagcaat gaaaagaaac tagctactga taccagctac aacatggatg    27060

gatttcaagt gctttatgat gagagcaaga agccagacac aaaagtgtct atatatatat    27120

acagtatata tacgtatata tacacatata tacagtatat atatacatat acatgtatat    27180

atatactgta tatatactgt atatatatac acagtatata tatacatata tacagtgtat    27240

atatactgtg tatatataca tgtatatata ctgtgtatat atacatgtat atatactgtg    27300

tatatataca tgtatatata ctgtgtatat atacatgtat atatatgtat actgtatata    27360

tactgtatat atatatacac atatatacag tatatatata cagtatatac tgtatatata    27420

cagtatatac gtgtatatat acatatatac agtatatatg taaatataca tatatacagt    27480

atatatgtaa atatacatat atacatgtat atatatacac tatatatata catatatagt    27540

gtatatatac atatatacat gtatatattt actatatgat tccatttata taaagtgcca    27600

aaacagtcaa aaataatcta tgtggaaaaa atcaacaaag ggatcccccg ggctgcagga    27660

attcgatggc gcgccgacgt cgcatgctcc tctagactcg aggaattcgg taccccgggt    27720

tcgaaatcga taagcttgga tcggccgcaa taaaatatct ttattttcat tacatctgtg    27780

tgttggtttt ttgtgtgaat cgtaactaac atacgctctc catcaaaaca aaacgaaaca    27840

aaacaaacta gcaaaatagg ctgtccccag tgcaagtgca ggtgccagaa catttctcta    27900

tcgaggatct gcgatcgctg aattctgggg actttccact ggggactttc cactggggac    27960

tttccactgg ggactttcca ctggggactt tccactcctg cagcagtgga tattcccaga    28020

aaactttttg gatgcagttg gggatttcct ctttactgga tgtggacaat atcctcctat    28080

tattcacagg aagcaatccc tcctataaaa gggcctcaga ggaagtagtg ttcagctgtt    28140

cttggctgac ttcacatcaa agctcctata ctgacctgag acagagccat gaattccgtt    28200

tttttttttt tttttggaaa tatgagggtt tttccgcttc tgacagtgga acggaatgac    28260

agcagcacag gctggtgaat gactactttc tttataagca accaccttga gcctgaaatg    28320

gcagtcgcta gtctctattg ccttgctgtg gcctcgggat ggaaatctgc tggggaccct    28380

acagtcacct aatctctctc cttctcatcc ttctgtttca ttcagaggca gcctgccgcc    28440

cttctgggaa aagaccctgc aagatgcaag ccttcagaat ctgggatact aaccagaaga    28500

ccttttacct gagaaacaac cagctcattg ctgggtactt acaaggacca aatatcaaac    28560

tagaagaaaa gatagacatg gtgcctattg accttcatag tgtgttcttg ggcatccacg    28620

ggggcaagct gtgcctgtct tgtgccaagt ctggagatga tatcaagctc cagctggagg    28680

aagttaacat cactgatctg agcaagaaca aagaagaaga caagcgcttt accttcatcc    28740

gctctgagaa aggccccacc accagctttg agtcagctgc ctgtccagga tggttcctct    28800

gcacaacact agaggctgac cgtcctgtga gcctcaccaa cacaccggaa gagcccctta    28860

tagtcacgaa gttctacttc caggaagacc aatagtctag ctcgacatga taagatacat    28920

tgatgagttt ggacaaacca caactagaat gcagtgaaaa aaatgcttta tttgtgaaat    28980

ttgtgatgct attgctttat ttgtgaaatt tgtgatgcta ttgctttatt tgtaaccatt    29040

ataagctgca ataaacaagt taacaacaac aattgcattc attttatgtt tcaggttcag    29100

ggggaggtgt gggaggtttt ttaaagcaag taaaacctct acaaatgtgg tagatccatt    29160

taaatgttag atccggagag ctcccaacgc gttgggtcga cggcgcgcct accagtaaaa    29220

aagaaaacct attaaaaaaa caccactcga cacggcacca gctcaatcag tcacagtgta    29280

aaaaagggcc aagtgcagag cgagtatata taggactaaa aaatgacgta acggttaaag    29340

tccacaaaaa acacccagaa aaccgcacgc gaacctacgc ccagaaacga aagccaaaaa    29400

acccacaact tcctcaaatc gtcacttccg ttttcccacg ttacgtcact tcccatttta    29460

agaaaactac aattcccaac acatacaagt tactccgccc taaaacctac gtcacccgcc    29520

ccgttcccac gccccgcgcc acgtcacaaa ctccaccccc tcattatcat attggcttca    29580

atccaaaata aggtatatta ttgatgatgt tt                                  29612


<210>  3
<211>  29273
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  helper-dependent adenoviral vector-equine Il-1Ra 
       gene

<400>  3
aaacatcatc aataatatac cttattttgg attgaagcca atatgataat gagggggtgg       60

agtttgtgac gtggcgcggg gcgtgggaac ggggcgggtg acgtagtagt gtggcggaag      120

tgtgatgttg caagtgtggc ggaacacatg taagcgacgg atgtggcaaa agtgacgttt      180

ttggtgtgcg ccggtgtaca caggaagtga caattttcgc gcggttttag gcggatgttg      240

tagtaaattt gggcgtaacc gagtaagatt tggccatttt cgcgggaaaa ctgaataaga      300

ggaagtgaaa tctgaataat tttgtgttac tcatagcgcg taatatttgt ctagggccgc      360

ggggactttg accgtttacg tggagactcg cccaggtgtt tttctcaggt gttttccgcg      420

ttccgggtca aagttggcgt tttgatatca agcttatcga taccgtaaac aagtctttaa      480

ttcaagcaag actttaacaa gttaaaagga gcttatgggt aggaagtagt gttatgatgt      540

atgggcataa agggttttaa tgggatagtg aaaatgtcta taataatact taaatggctg      600

cccaatcacc tacaggattg atgtaaacat ggaaaaggtc aaaaacttgg gtcactaaaa      660

tagatgatta atggagagga tgaggttgat agttaaatgt agataagtgg tcttattctc      720

aataaaaatg tgaacataag gcgagtttct acaaagatgg acaggactca ttcatgaaac      780

agcaaaaact ggacatttgt tctaatcttt gaagagtatg aaaaattcct attttaaagg      840

taaaacagta actcacagga aataccaacc caacataaaa tcagaaacaa tagtctaaag      900

taataaaaat caaacgtttg cacgatcaaa ttatgaatga aattcactac taaaattcac      960

actgattttg tttcatccac agtgtcaatg ttgtgatgca tttcaattgt gtgacacagg     1020

cagactgtgg atcaaaagtg gtttctggtg cgacttactc tcttgagtat acctgcagtc     1080

ccctttctta agtgtgttaa aaaaaaaggg ggatttcttc aattcgccaa tactctagct     1140

ctccatgtgc tttctaggaa acaagtgtta acccacctta tttgtcaaac ctagctccaa     1200

aggacttttg actccccaca aaccgatgta gctcaagaga gggtatctgt caccagtatg     1260

tatagtgaaa aaagtatccc aagtcccaac agcaattcct aaaaggagtt tatttaaaaa     1320

accacacaca cctgtaaaat aagtatatat cctccaaggt gactagtttt aaaaaaacag     1380

tattggcttt gatgtaaagt actagtgaat atgttagaaa aatctcactg taaccaagtg     1440

aaatgaaagc aagtatggtt tgcagagatt caaagaaaat ataagaaaac ctactgttgc     1500

cactaaaaag aatcatatat taaatatact cacacaatag ctcttcagtc tgataaaatc     1560

tacagtcata ggaatggatc tatcactatt tctattcagt gctttgatgt aatccagcag     1620

gtcagcaaag aatttatagc cccccttgag cacacagagg gctacaatgt gatggcctcc     1680

catctccttc atcacatctc gagcaagacg ttcagtccta cagaaataaa atcaggaatt     1740

taatagaaag tttcatacat taaactttat aacaaacacc tcttagtcat taaacttcca     1800

caccaacctg ggcaatatag tgagacccca tgcctgcaaa aaaaaaaaaa ttagccaggc     1860

atggtagcat gtacctgtag tcccagctac ttgagaggtg aggtgggaaa atcactttag     1920

tgcaggatgt tgaggctgga gtgaactgtg attgtgccac tgcactccag cctggacaat     1980

agagcaagac cttgtctcaa aaaaatgcat taaaaatttt ttttaaatct tccacgtatc     2040

acatcctttg ccctcatgtt tcataaggta aaaaatttga taccttcaaa aaaaccaagc     2100

ataccactat cataattttt tttaaatgca aataaaaaca agataccatt ttcacctatc     2160

agactggcag gttctgatta aatgaaattt tctggataat atacaatatt aagagagact     2220

gtagaaactg ggccagtggc tcatgcctgt aatcccagca ctttgggagg ctgggtaaca     2280

tggcgaaccc tgtttctaca aaataaaaat attagctggg agtggtggcg cacacctata     2340

gtcccagcta ctcaggaggc tgaggtggaa ggatcgcttg aacccaggag gttgagactg     2400

cagtgaactg tgatcattct gctgcactgc accccagcct gggcaacaga gaccttgtct     2460

caaaaaaaaa aaaaaaagag acaaattgtg aagagaaagg tactctcata taacatcagg     2520

agtataaaat gattcaactt cttagaggaa aatttggcaa taccaaaata ttcaataaac     2580

tctttcccct tgacccagaa attccacttg aataaagctg aacaagtacc aaacatgtaa     2640

aagaatgttt cttctagtac agtcggtaag aacaaaatag tgtctatcaa tagtggactg     2700

gttaaatcag ttatggtatc tccataagac agaatgctat gcaaccttta aaatatatta     2760

gatagctcta gacacactaa tattaaaagt gtccaataac atttaaaact atactcatac     2820

gttaaaatat aaatgtatat atgtactttt gcatatagta tacatgcata ggccagtgct     2880

tgagaagaaa tgtgtacaga aggctgaaag gagagaactt tagtcttctt gtttatggcc     2940

tccatagtta gaatatttta taacacaaat attttgatat tataatttta aaataaaaac     3000

acagaatagc cagacataca atgcaagcat tcaataccag gtaaggtttt tcactgtaat     3060

tgacttaaca gaaaattttc aagctagatg tgcataataa taaaaatctg accttgcctt     3120

catgtgattc agccccagtc cattaccctg tttaggactg agaaatgcaa gactctggct     3180

agagttcctt cttccatctc ccttcaatgt ttactttgtt ctggtcccta cagagtccca     3240

ctataccaca actgatacta agtaattagt aaggccctcc tcttttattt ttaataaaga     3300

agattttaga aagcatcagt tatttaataa gttggcctag tttatgttca aatagcaagt     3360

actcagaaca gctgctgatg tttgaaatta acacaagaaa aagtaaaaaa cctcatttta     3420

agatcttact tacctgtcca taattagtcc atgaggaata aacacccttt ccaaatcctc     3480

agcataatga ttaggtatgc aaaataaatc aaggtcataa cctggttcat catcactaat     3540

ctgaaaaaga aatatagctg tttcaatgag agcattacag gatacaaaca tttgattgga     3600

ttaagatgtt aaaaaataac cttagtctat cagagaaatt taggtgtaag atgatattag     3660

taactgttaa ctttgtaggt atgataatga attatgtaag aaaacaacag gccgggcggg     3720

ttggttcaca cgtgtaatcc cagcactttg ggaggctgag gcaggcagac tgcctgagct     3780

caggagttcg agaccagcct gggcaacacg gtgaaatccc gtctctacta aaaatacaaa     3840

aaaattagcc gggtgtggtg acacatgcct gtagtcccag ctacttggga ggctgaggca     3900

ggagaatcac ttgaacctgg gaggtgaagg ttgcagtgag ccaagatggc accacttcac     3960

tccagcctgg gaaacagagc aagactctgt ctctgagctg agatggcacc acttcactcc     4020

agcctgggaa acagagcaag actctgtctc aaaaaaaaca aaacacacaa acaaaaaaac     4080

aggctgggcg cggtggctca cgcctgtaat cccagcactt tgggaggccg aggcgggtgg     4140

atcacctgag gtcaggagtt ccagaccagc cttgtcaaca tggtgaaacc tccccccgcc     4200

gtctctacta aaaatacaaa aattagccag gcgtggtggc aggagcctgt aatcccagct     4260

acttgggagg ctgaggcagg agaatcgctt gtacccagaa ggcagaggtt gcactgagct     4320

gagatggcac cattgcactc cagcctgggg gacaagagcg agatttcgtc tttaaaaaac     4380

aaaaacaaaa caaaaaacca tgtaactata tgtcttagtc atcttagtca agaatgtaga     4440

agtaaagtga taagatatgg aatttccttt aggtcacaaa gagaaaaaga aaaattttaa     4500

agagctaaga caaacgcagc aaaatcttta tatttaataa tattctaaac atgggtgatg     4560

aacatacggg tattcattat actattctct ccacttttga gtatgtttga aaatttagta     4620

aaacaagttt taacacactg tagtctaaca agataaaata tcacactgaa caggaaaaac     4680

tggcatggtg tggtggctca cacttgtaat cccagtgctt tgggaggctg agacaggaga     4740

gttgcttgag gccaggagtt caagaccgac atggggaatg tagcaagacc ccgtccctac     4800

aaaaaacttt gtaaaaattt gccaggtatg gtggtgcata cctgtagtcc cagctactcg     4860

ggaggcggag gcagaaggaa tcacttgagc ccaggagttt gaggctgcag tgagctacga     4920

tcataccaca gcactccagc gtggacaaca gagtaagacc ctatctcaaa aacaaaacaa     4980

aacaaaacaa acaaaaaaaa ccacaagaaa aactgctggc tgatgcagcg gctcatgcct     5040

gtaatcccag tattttggga ggcccaggtg ggcgtatcac ctgaggtcag gagttagaga     5100

ccagcctggc caacatggtg aaaccccatc tctactaaaa atacaaaatt agccaggcat     5160

gtggcacgcg cctgtagtcc cagttactgg gaggctgaag caggaggatc acctgagccc     5220

gggaggtgga ggttgcagtg agccgagatc acaccactgc actccagcct gggtgacaca     5280

gcaataccct acctcaaaat aaaaaagaaa aagaaaagaa aagttgctgt ccccgctacc     5340

ccaatcccaa atccaaacag cctctctcat ctcacagtaa gggggaaaaa tcacccaaaa     5400

aagctaagtg atcttttgaa aacccaaact cttagaagtc taagattatt atagtcaact     5460

catgaagtgt catcataaaa gatactctaa tattatttaa gtagaaccac atattggttg     5520

tcttggtatg tctagcccct ggcatacaaa atatttaata acactgatat ggtacctgtg     5580

atgtgaaaat gtactatgag tacagcttta taaatactat atatgtacct atatacagaa     5640

aaaaatacaa caaaatcata aaagcactta tctttgaaag aggagttaca gcaattttat     5700

ttagttcttt attgctttgc tatatattct aaattttttt caatgaatat atatcacttt     5760

taaaaaaatt caatggtctt tcttataaat tatctttggc agcatgcgtt tttatatata     5820

catataaaat gtatgggaaa tttttaaagg atacattaaa ttaaagcaaa atatacaaac     5880

aaaaaatcag aatacaaaaa gataaaaaga ttgggaaggg agggagggag taaggaggaa     5940

gggtgggtgg gtatagagaa atataccaaa taatggtaag aagtggggtc ttgacacttt     6000

ctacactttt tttaaataaa aaaaattttt ttctctctct tttttttttt tagagacgaa     6060

gtctcgctat gttgcccagg ctggtcttga actcctggga tcaagagatc ctcctgcctc     6120

agcctcccaa ggtgcttgga ttacaggtgt gagccaccac gcctggtcac tttctacact     6180

ttaatatata tattttttca ttttcaatgt catttttatt agttaattta taatacccat     6240

tcaccattat attcaaagtc tatttgaaga aataaaccag aaagaatgaa atactctagc     6300

tcacatgcta ttcaatacta aattaccttt caaatcacat tcaagaagct gatgatttaa     6360

gctttggcgg tttccaataa atattggtca aaccataatt aaatctcaat atatcagtta     6420

gtacctattg agcatctcct tttacaacct aagcattgta ttaggtgctt aaatacaagc     6480

agcttgactt ttaatacatt taaaaataca tatttaagac ttaaaatctt atttatggaa     6540

ttcagttata ttttgaggtt tccagtgctg agaaatttga ggtttgtgct gtctttcagt     6600

ccccaaagct cagttctgag ttctcagact ttggtggaac ttcatgtatt gtcaggttgg     6660

cccgtaatac ctgtgggaca acttcagccc ctgtgcacat ggccaggagg ctggttgcaa     6720

acattttcag gtaggtggac caggacatgc ccctggtcat ggccaggtgg aggcatagtg     6780

ctatacagca ggcagaagtc aatattgatt tgtttttaaa gaaacatgta ctactttcat     6840

aagcagaaaa aatttctatt cttgggggaa aagattatgc cagatcctct aggattaaat     6900

gctgatgcat ctgctaaacc ttcacatatc agaacatatt tactatagaa agaatgaaaa     6960

tgggacattt gtgtgtcacc tatgtgaaca ttccaaaaat attttacaac aactaagtat     7020

tttataaatt ttatgaactg aaatttagtt caagttctag gaaaatacaa accttgctag     7080

atattataaa aatgatacaa tatatattca tttcaggctc atcagaatat atctgttatc     7140

acttgacaag aatgaaaatg caccattttg tagtgcttta aaatcaggaa gatccagagt     7200

actaaaaatg acttcttcct tgaagcttac tcaccaactt cctcccagtt actcactgct     7260

tctgccacaa gcataaacta ggacccagcc agaactccct tgaaatatac acttgcaacg     7320

attactgcat ctatcaaaat ggttcagtgc ctggctacag gttctgcaga tcgactaaga     7380

atttgaaaag tcttgtttat ttcaaaggaa gcccatgtga attctgccca gagttcatcc     7440

cagatatgca gtctaagaat acagacagat cagcagagat gtattctaaa acaggaattc     7500

tggcaatata acaaattgat ttccaatcaa aacagattta cataccatac ttatgtcaag     7560

aagttgtttt gttttattgc atcctagatt ttattttttt gatttatggt ttactttaag     7620

cataaaaaat ttgtcaatac aactcttccc aaaaggcata aacaaaaatt cataaaactt     7680

gcatcacttg agatacttca ggtatgaatt cacaactttg ttacaactta ctatatatat     7740

gcacacatat atatatattt gggtatattg ggggggttct aatttaagaa atgcataatt     7800

ggctatagac agacagttgt cagaacttgg caatgggtac gtgcaggttc attataccaa     7860

gtctacttgt agttgttcaa aatgtatcat aatacaaggc cgggcgaggt cgtcacgcct     7920

gtaatcccag cattttggga ggctaaggca ggaggattgc ttgaggtcag gagtttgtga     7980

ccagcctggg caacagagca agaccctgtc tccaaaaaga aaaaaaataa ttttttacaa     8040

aataaaaaca aaatgtatca tcagacgaaa ttaaataaga ggcaattcat ttaaatgaca     8100

acttttccca gcttgacatt taacaaaaag tctaagtcct cttaattcat atttaatgat     8160

caaatatcaa atactaattt tttttttttt tttttttttg agacggagtc tcgctctgtc     8220

gcccaggctg gagtgcagtg gcgcgatcct ggctcactgc aagctccgcc tcccgggttc     8280

acgccattct cctgcctcag cctcccgagt agctgggatt acagacatgc gccaccacgc     8340

ccggctaatt ttgtattttt agtagagatg gggtttctcc atgttggtca ggctggtctt     8400

gaatttccca cctcaggtga tctgcctgcc tcagcctcac aaagcagtag ctgggactac     8460

aggcacccac caccacactt ggttaattct tttgtatttt ttttgtaaag acgggatttc     8520

accatgttag ccaggatggt ctcgatctcc tgatctcatg atccgcccgc ctcagcctcc     8580

caaagtgctg ggattacagg cgtgagccac cccgcccggc catcaaatac taattcttaa     8640

atggtaagga cccactattc agaacctgta tccttatcac taatatgcaa atatttattg     8700

aatacttact atgtcatgca tactagagag agttagataa atttgataca gctaccctca     8760

cagaacttac agtgtaatag atggcatgac atgtacatga gtaactgtga acagtgttaa     8820

attgctattt aaaaaaaaag acggctgggc gctgtggctc atgcctgtaa tcccagcact     8880

ttgggaggcc aaggcaagtt gatcgctcga ggtcaagagt tcgagaccag cctggccaac     8940

gtggtaaaac cccgtctcta ctaaaaatac aaaaaaaaaa ttagccaggc atggtggcac     9000

aggcctgtaa tcccagctac tagggaggct gagacatgga gaactgcttg aatccaggag     9060

gcagaggtta cagtgagccg agatcatacc actacactcc agcctgagtg acagagcgag     9120

actcctgtct aaaaaaaaaa aaaaaaaaaa agatacaggt taagtgttat ggtagttgaa     9180

gagagaactc aaactctgtc tcagaagcct cacttgcatg tggaccactg atatgaaata     9240

atataaatag gtataattca ataaatagga acttcagttt taatcatccc aaacaccaaa     9300

acttcctatc aaacaggtcc aataaactca atctctataa gagctagaca gaaatctact     9360

tggtggccta taatcttatt agcccttact tgtcccatct gatattaatt aaccccatct     9420

aatatggatt agttaacaat ccagtggctg ctttgacagg aacagttgga gagagttggg     9480

gattgcaaca tattcaatta tacaaaaatg cattcagcat ctaccttgat taaggcagtg     9540

tgcaacagaa tttgcaggag agtaaaagaa tgattataaa tttacaaccc ttaaagagct     9600

atagctgggc gtggtggctc atgcctgtaa atcccagcac tttgggaggc tgaggcgggt     9660

ggatcacctg aggccagaag ttcaagacca gcctagccaa catggcgaaa ccctgtctct     9720

acaaaaaata caaaaattag ccgggtgtgg tggcacgtgc ctgtagtccc agttacttgg     9780

gaggccgagg caggagaatc gcttgaacct aggaggtgga ggctgcagtg agccgagatt     9840

gtgccactgc actccacttc agcctgggcg acaagagcaa gactccgtca caaaaaaaaa     9900

aaaaaaaaaa aagcttaaaa tctagtggga aaggcatata tacatacaac taactgtata     9960

gcataataaa gctcataatc tgtaacaaaa tctaattcga caagcccaga aacttgtgat    10020

ttaccaaaaa cagttatata tacacaaaaa gtaaacctag aacccaaagt tacccagcac    10080

caatgattct ctccctaagc agtatcaagt ttaaagcagt gattacattc tactgcctag    10140

attgtaaact gagtaaagga gaccagcacc tttctgctac tgaactagca cagccgtgta    10200

aaccaacaag gcaatggcag tgcccaactt tctgtatgaa tataagttac atctgtttta    10260

ttatttgtga cttggtgttg catgtggtta ttatcaacac cttctgaaag aacaactacc    10320

tgctcaggct gccataacaa aataccacag actgagtgac ttaacagaaa cttatttctc    10380

acagttttgg aggctgggaa gtccaaaatt aaggtacctg caaggtaggt ttcaatctca    10440

ggcctcttct ttggcttgaa ggtcttctaa ctgtgtgctc acatgacctc ttctaacaag    10500

ctctctggtg tctctttttt tttttttttc ttttttgaga cagagtctca ctctgtcacc    10560

caggctggag tacagtggca caatctgggc tcactgcaac ctccaactcc cgggttcaag    10620

tgattctcat gcctcaccct cccgagtagc ttggatgaca ggagcccgct accacaccca    10680

gctaattttt gtatttttag tagagatggt gtttcactac attggccagg ctggtctcaa    10740

actcctgacc tcgtgatcca cccaccttgg cctcccaaag tgctgggatt acaggtgtga    10800

gccactgcgc ccgtcctggt gtcttttcat ataagggcac taatccaatc agacctgggc    10860

ccaaccctcc cgacttcttc taactgtaat taccttccaa aggccctgtc tccaaatacc    10920

atcacactgg gggttaggac ttcaaaaaag gtatgggggg ggtgtgggag gacataaatg    10980

ctcagtccat aacaagcacc caacataaaa atggctagaa cagatcacaa aaaaaaggtc    11040

ctgtatggct ttggggaagg gctcaacccc aaaatatctg agagctctgg aggggcctag    11100

aagtggtaaa tgaatgaaaa cgtggttact ctccagatct gcctttccca aatatggcca    11160

ttcttggctg aatcagaaat caaaggacag gttattaatt actagctcta agttacttac    11220

catttgctga gacagttcag aaatctgact gcatctcctc agagatctag aacacagttc    11280

tcaaattcta acttacttgt gatatacttg tgaatgataa aaatcgctac aggtactttt    11340

attaatctga aagagtattg agaaattacc tttcattctg acttttgtct ggaatgaaaa    11400

tcaatacttt tgctataatc gattactgaa ataattttac tttccagtaa aactggcatt    11460

ataatttttt ttaattttta aaacttcata attttttgcc agactgaccc atgtaaacat    11520

acaaattact aataattatg cacgtcacat ctgtaataat ggccttcatg taaacatttt    11580

tgtggtttac acataaaatc tctaattaca aagctatatt atctaaaatt acagtaagca    11640

agaaaattaa tccaagctaa gacaatactt gcaacatcaa ttcatcatct gtgacaagga    11700

ctgcttaagt ctctttgtgg ttaaaaagga aaaaaaaaaa aaagacatgt tggccagatg    11760

cggtggctca cacctgtaat cccagcactt tgggaggctg aggtgggcgg atcacccctg    11820

gcctgcccaa catggtgaaa ccccgtctct actaaaaaca caaaaattag ctgggcgtgg    11880

tggcgggcgc ctgtaattcc agctactcgg gaggctgagg caggagaatt gctagaaccc    11940

aggaggcaga gattgcagtg agctgagatt gcaccattgc actacagtct gggcaacaaa    12000

agtgaaactc catcttaaaa aaaaaaagac aatgttcgtg ggtccaaaca agacttaatg    12060

gaagtgagtc taaaaatgag ctatgtgggc caggcgtagt ggctcccacc tgtaatccca    12120

gcactttggg aggccgaagc aggcagatca tgaggtcagg agatggagac catcctggcc    12180

aacacggtga aatcctgtct ctacaaaaat tagctgggcg tggtggtgcc tgcctgtaat    12240

cccagctact cagaaggctc aggcaggaga atcgcttgaa ccagggagtc ggtggctaga    12300

gtgagccgag atttgcatca ctgcactcct gcctggtgac agagcaagac tccatctcaa    12360

aaaaaacaaa caaaaataaa agataaaaat gagctatgtg aattaaaaga ggtataacaa    12420

tagataaacc atattttatt taattcctag taatgagtaa tatttccaaa cttctggaat    12480

gggcagaaat tgctagttgg catattttta ccttttatat tcagatacat taaaattctc    12540

aaaaaaaaac acctcaaagc agatgatccg ccatctcctt ggataatttg tgttaactca    12600

ggataacaga aaaccaaaat tatgagttac tgatgcaata ttcctaaatg taaaaataat    12660

taaagctaat agtagattca tcttccaatt tcatatcagt cttacaaata aactacatat    12720

ataacttgct tgccttccct tctgagggat aaagctgtta gaagaattaa aatcagcatt    12780

cttgactatt caaccaaggg agggataaat tattactcat tctagggaca tgggctcata    12840

actactacat gtgtaaggac atgaatttac ccaatattac aatttttcct tttattagtg    12900

tgtacagtgg aagaatagac atgttcactc tggacaaaaa aaaaattata cttatcagtt    12960

atcagaagca caatgctgaa gacagtagtt ccataacaat ttgaagtatg tgatcgaact    13020

agtagattat cttagtagta gtgaattatt gtaaatgtta gtaatttggc agccactggg    13080

cagaaaaata agaattgagg ctcaatattg atattaatgg tggtgattga cacataaatt    13140

ttatcaagtc tacacaatat aaaattacag aaaggtagaa gagtatacca gtacaacttc    13200

aacatatctt cactacaagg gagtaaaatg acatggccta gttactatct aatgaactgc    13260

agaaaactaa aagaaaactc caaggcaact cttctctgct gatctggttg gtccttttcc    13320

taccttttgc aatacccaga tacaaacaat ggatagaaaa caaagtagac ttgtagtatg    13380

caggtcacag tgctaaattc acagaaagaa acccctgaac tgaactgctc tatttcctgg    13440

tggtcacaaa gagtaattct ggtttacacc tacagattga tgtcaatcta caccctgttg    13500

ataacagtgt ggccaaggac aaaaaaaagg tgctccgttt taccaattct gtaaaaaatt    13560

attggcaggg taagctcggc tagggcagga ttacatttct aggactacca tccccgaaat    13620

ttagaagata ttatatccac ataaagcata tctttcacat taatttgcaa aaatctaaaa    13680

gctttttctt agctcaagtg tgtccaagtt taccctggca gtttaaaacg atagttacaa    13740

gcagcatggg ttgtatcaga cacatttgag ggccaatttc atgtaagtga tattgggcaa    13800

gttacttcaa ctatctgtgc ctccaaggtc atactagtgt ttatttacct aaagggtacc    13860

tgttatgtaa ctttagggtg tttacattag ataatgcctg caaaatattt acttcaacgc    13920

ctaaaacata gttaagtatt caataaatac ctactattgt cactactaac ttaaaagttt    13980

agagattaag agcagaatct ggggtgagac aaacttaggt tcaaatccta gtattgttgg    14040

gtaatcttgg gcaagttact taacctctct gatttgtgta atttaaaaaa ttagttaata    14100

tacataacag ggcttagaag agtatctagc acatagcacc atttaagcat ttgttattgc    14160

taacatgcaa acaatttaag ggaaagaaat tttttaaaaa ggaagaggga tttgcaaact    14220

aaaaacaatg agtatcttat gttcaaagaa aactaacaaa cagccagctc tagcaataat    14280

taaattcact atatactggg gcaggcatca caccccaaag ctaaaagcgt ctacctaggc    14340

caggcacggt ggctcatgcc tgtaatccca gcactttggg aagcagaggc gggcagatcg    14400

cttgagctca ggagttcaag accagcctgg acaacatggc aaaacaccat ctctacaaaa    14460

aatacaaata ttaggccggg cgcagtggct cacgcctgta atcccagcac tttgggaggc    14520

caaggcgggt ggatcacctg agatcaggag ttcgagagta gcctggccaa catggtgaaa    14580

cctcgtctct attaaaaata caaaaaatta gccaggcatg gtggcaggcg cctgtaatcc    14640

cagctactca gggggatgag gtaggagaat cgcttgaacc cgggaggcag aggttgcact    14700

gagccgagat catgccactg tactccagcc cgggcaacaa gagcgaaact ccatctcaaa    14760

aaataaataa ataaataaat aaaataaagt acaaatatta gccagggatg gtggtgcgca    14820

cctgtagtcc cagctacttg ggaggctgaa gtgggagaat cccctgagcc tggggagaat    14880

cacccgagcc cgggaagtcg aggctgcagt gagcagtgat tgtgccactg cactccatcc    14940

taggtgacag agtgagaccc tgtctcaaaa aaaagaaatt ggcagaatta agtaagttga    15000

tgtttagaga tgaaaaatca acattttttc ctcagcaact gaataaaaac aacagccact    15060

accatttttt tgagtaccta tttgtagcct attttttaac tggtattact cgagagagag    15120

agagctaggt tcgagacaga gctccttctc ttaataactg tatgacctag ggtatgtctg    15180

ttagcctctc tgaggcttca aaggttcctc atctgtaaaa tggtaataat cataccattg    15240

ctacagggct gttttgaaga ctaattagga ctatgtaagt aaacatgatg atggctatta    15300

ttactgttcc ccgccagggg ccatgcaagg gttgctgatt cacatagact gtcttataat    15360

cctctcaata actccaagag gtagccagca cctcagatat acataaaatg acttaagccc    15420

agagaggtga agtaagttgc ccacagccac acaactagta aatagcccaa acaagctgga    15480

ttcccagtta gactccgtta atagcactgc tctttacctt aagtcattac aatgcctaat    15540

atgaaataga atcgcttctt tcttagggtt caagtggtta attatttaat gtattcattc    15600

aacaaaccat catcgaggac ctcttacaag ccaagtactg tgctaagtgc tagagttacg    15660

gcggtgattc ctgcccttaa aaagttttag tgggagaaac aacaggtaac caggtcattg    15720

ccaaaacaac aaaaataatc ataataaagc aggctaaagc atatttaact ggccggggtt    15780

ttgactattt tagcaagcat gatcagaacg gttgaggagg gaggccagca gcttggccgg    15840

ttcaacaaac aagaaaaaac cagtgagggt ggagctaaga taccagaggc tgattacggt    15900

taagaatgtt cttgaaggta aggaccagat tctcattttc tatatcctgg ggcatcggtc    15960

agcatggaat ctggattcta gcacatgtga atttcggctt gaaatgacct aatgcctttt    16020

ccctagttcc ttcgtgtgtc aaatacgcat ggttaccgct accagagctg tagtggggct    16080

tcaatgaggc catgagcatc tccataaaga tgaactacag tgtgtgcaaa actaaaggca    16140

aaacctggtc cccacacgcc ctcccaggtg gtcgctttcc gtgccgaggc ccctccagag    16200

gtgccccgag aacctcacca tcgcacccca aacttccagg gaagggcctc tcccgagaaa    16260

gcccccacgc ccccaccccg cgccatcatt cccgaatctg ccctcggccc ctccccgcag    16320

cacgctcgca ggcggcacat gtcaaccaaa acgccatttc caccttctct tcccacacgc    16380

agtcctcttt tcccagggct cccccgagga gggacccacc ccaaaccccg ccattccgtc    16440

ctccctgccg ccctcgcgtg acgtaaagcc gaacccggga aactggccgc ccccgcctgc    16500

ggggttccct gggcccggcc gctctagaac tagtggatcc caattgaagg cctggtctaa    16560

atgactccaa aatcaccact taattcaaga gactgatttc cctgagtcag gccccttaaa    16620

gcagctattt caatgggaca gggaaacaac cctaggatct ggattagaat cacttggggg    16680

ctgccacacc cccagggctc tgatcctgcc cttctcccac acgcacattc acatactgct    16740

gcagtgacct tccatttcta atgggttcct gggccatctg tcaggtatag ggaatggaaa    16800

aggggttggg gaggctctgc ttcagaaagt ttgtgtcagg ggctcccaga gcctccacag    16860

atagatagca ggggtcccca ccctaccatg gcagctataa atgtgatcaa catttattgg    16920

cctaggatac agcagttagc aaaatgcctg atgtagttcc cactccgtgg aggttgcagg    16980

ctagccaaga agtcatgagt tcagcaaccc ttacgcacca gtgggatgag attggaccag    17040

gccgagggta gtcttgggaa cactcagcat ttgtctgagg gccagaagag gctgcttgcc    17100

ctcagacagg aggtcagcat ctttattgta gcccatgaca cctctacacc attgctcttc    17160

tggtcttatg gaagacatct ttgggcctga taacagcgga gtctgtgtcc cacttgtcca    17220

ggctggagtg ccacatcagg cacactccag ttgcagggac agcacagaca agtttcagga    17280

aggctggtgg cctccaggag gttaacctta taaggccaga ttgtaaccta gttgaaaaac    17340

atacacatgc catgataata aaagaaccta ggcaccatta caagagaaaa aatcattttt    17400

gtagatacga gcatggattc ttgggtgggt cagacacact gggcttgtgc tctgactgca    17460

ctgtctcccc tacctgacct tgggtaaacc ataagactgc tgcatgactc agtgtccacc    17520

ccaaaaaagt accggtagat attggccaca gtagatatca gctagagtgg actctcatga    17580

caatgagggg agatgtattc cccatcttag gcacctggga ctctaccttc catcttctgc    17640

tccgtgtctc tccatcccca ggctcttcag aactcaggga gtccagaatg tcagctccca    17700

gatttcagcc ttcagaaagg aaacccatta ccgttcagtt gaacaaatgt tgtctgagcc    17760

ccagatctgg gctcagaggc catctaggct atgagacaag aggggaacaa agcaccgtct    17820

gcactcactc accacactca cttgctgtcc caggtcacat ccatcgggta gagaatctaa    17880

gaggctgagc tagctcccgc caccagccca gcccacccca cctggcccct tccttccttc    17940

tacaaaatat gcaccacctg tcaaagggtg ggcagtgcca ggcctgcata cagagcactg    18000

agtgtaaaag cagacatgga ccctgacctc caggagcttc caattttctt gaagagacaa    18060

atcagctggc atttcagtcc agtgtgatct gctcttggtg agcacagacc tagggagttg    18120

gggcagcttc ccagaagaac tgcagtccag gctgagggca gagaaatgag gggaatggcg    18180

aggaattggg gagcaggggg gagctcagta gagagccaag ggcgggaggt gagaagtccg    18240

tgttgggcca ggagctaccc tccggtggcc acagccgaag tcgaggatgc ctttggaact    18300

catccccact tctctctttc tgtatgtagc cgtccaagaa caagtcacct ccaagtgtag    18360

ccggatcaag gcaagccccc catctagcaa gcacttgatg ccacccagaa ctgggcttct    18420

tcagaacaat ctgagtccag gaatgatccc actcaccagg caccagagct gcgagggcat    18480

gggagtgatc tcaccaactc tggggaagcg gcaaggaatt ttcacctcca gcccccagtg    18540

tcccatcctc tcacactcag gccagactcc cctgggcaga cttgactctg tctgccagca    18600

tatgcagagc cccaaggcca ccccaccaga agtgcccctg cctgggttct gtcccagctc    18660

cctgggcacc cagtccttga gtccccacca gctcagacgg cctagtgtgc caagaatgcc    18720

cactgcgttc aacaatgctg catgggtcac agcggcagca gctgtgacca cagcagtttc    18780

ggggaaaaca cccctcagcc aagtggataa tagcgttcag cagcactcac cttctggcca    18840

ggcctgcctt cagaggccat ctgattggga ggcacaagtg cccgctgcga tgggaacaca    18900

agtgcccctg gccaacaacc ccagcttcag cctgctgggc agccagagcc tcaggcagag    18960

cccggtacag ggcccggtgc ctgtagcaaa caccaccaag ttcctccagc agggtatggc    19020

cagctttagt cccctgagcc ccatacaggg catcgagcca ccaagctatg tggctgctgc    19080

tgccaccgct gctgctgctt ctgccgttgc tgccagccag ttcccaggtc cgttcgacag    19140

aacggatatt ccccctgagc tgccacctgc cgactttttg cgccagcccc aacccccact    19200

aaatgatctg atttcgtcac ctgactgcaa tgaggtagat ttcattgaag ctctcttgaa    19260

aggctcctgt gtgagcccag atgaagactg ggtgtgcaac ttgaggctga tcgacgacat    19320

tttggaacag catgctgctg ctcaaaatgc cacagcccag aattctgggc aagtcaccca    19380

ggatgctggg gcactttaaa tctgagcagg atgcccatag aaacccccat ggtgacatca    19440

ctctaggaag tggtgtcgat ccatacccgc agttgtctcc cgttacaatt tgagtggtgt    19500

tgtcagccca tgcttatccc tctctctacc tgtgacaaaa tggaaagctg gtgatttttc    19560

aagctacgtg tacatatttg aaaattttgt aaatggtttt cctaaacatt aatgacagaa    19620

gtatttatac ttcattttgt gactttgtaa ataaagcgac ggcttttgtt tcagtagagt    19680

tgtgtttact atgcattgtt ttgtgtttat tatacaatgt tacaaatatg cagaccgtgt    19740

tgtttgctcc agtgatacct tgttaagcta ggtggctgag tcgcttatgg ttttaatgca    19800

atgagcaatg tggatatgac caagagttgt tgtgcaagtt gacaaatgcc aaatagaaaa    19860

ccacttggcc atttatttct atgttcacta aaaatcctat tgccttgtgt gattcttaat    19920

ctcttttgcg aacctttcag tctccgctag ctctttccta atgagcttta cagcagaagc    19980

tgttttatcg ttaagtgccc cacagagaca ctttaccagg aggctgggag agttctccag    20040

atttgggaga ggcgcagaga cagtgtgtga gccgagccct gtctcagcaa tccacctgga    20100

ggagctagag tatcctcctc cctttaccat tcagaccgag agaaaaagcc cagcttgtgt    20160

gcaccctcgt ggggttaagg cgagctgttc ctggtttaaa gcctttcagt atttgttttg    20220

atgtaaggct ctgtggtttg ggggggaaca tctgtaaaca ttattagttg atttggggtt    20280

tgtctttgat ggtttctatc tgcaattatc gtcatgtata tttaagtgtc tgttatagaa    20340

aacccacacc cactgtcctg taaacttttc tcagtgtcca gactttctgt aatcacattt    20400

taattgccac ctcgtatttc acctctacat ttgaaatctg gcgtctgttt caagccagtg    20460

tgttttttct tcgttctgta ataaacagcc aggagaaaag tgcctctatg tttttatttt    20520

tcaagggagt attcagtacc tacaaaccca agtcaggaag cctgctagtg gctttggttc    20580

tttcagaggc tgctcgatgc cttgtgtgtc agaaagaaag attcagcagt tttgcatcat    20640

ggcaaagaag cctgttattt tggggctcag cccctcattt tatagaggat gaaacagagg    20700

gggatgggag gtcacaaaga caactgcccc gggagcaggt gtgggggaga cttgccctga    20760

gggtctagac gctctgcacc accgtcctgt ctcccttgct gaagaccaca catgcccttc    20820

tttgaccaga ccctgccacc tgataggcca ggacctggta ggcgggtacc caggtttcat    20880

ggatggaacc acatctcccc aaaagtgggg aggtagctac tgggatgcac gcctcccgcc    20940

atgtgctata ggagagcagc tgaagcaaca gttgggatca gatgtagtca caattgaatg    21000

catcatcaca tttatccctc taagtggctg ggagagttga tatcctcatc cctaaggtac    21060

aaaatgttcc aatttgatca gtggctttca ggagctgaga aaggcatgtg ctctgaggca    21120

gagctgttat gtcccgcaga gcctaaaaat gctctaagaa catgctccct gccaaaattc    21180

tcaatggctg tgacaaggga caacgatcga ccaatggggg tggaagcaga cctccgcagt    21240

ccaggggcca gagctaggac agaggggtcg gagaaagagt cattttccca acactccagc    21300

tcttggccag tcctcacaca gtcccctcct gcttcctgct gagagagata tcctcatagg    21360

tctgggtaaa gtccttcagt cagctttcat tccctgtcac caactttgtc tctgttctcc    21420

ctgcccgtct caggcagcac tcctcaggaa acctctccaa gagccagcct cactgcagcg    21480

cccactattg tccctctgcc tcaagtgtcc catccatgcc aggccccagg caggctgcag    21540

ctttccctca gggccacacc aaagcacttg ggctcagctg tgctgtcccc ctccatcact    21600

gagctcaggg gcagcagggg tggggtgcca ggaggcccat tcacccttct ctggctctgt    21660

gttggaccca cctgcccagc cactgctgct tagaacctac ccgctgggaa aatgaagccc    21720

tcccggaggg gccacctcaa cctgagagcc tcacggatca cagttgtccc cactcagctc    21780

tgccagccct cagagaccca tagataaaag ctgagcttgg ctcgcagagc tggttccatc    21840

ttccattccc agagggttca acttcctacc ccaaccacac agggaacctc aaggctgagc    21900

cagtgtgggc tgcagtgcag accagcttcc tggacacgtc ctgccacctg accccaggct    21960

ggcctcactg cccctggcac tcctgaccct atcctcattc ctcctggcag tgcgtgttct    22020

gccattccgc tttcccttag ctgtcctctc actgtactgt cagcttctcc ttttccaggt    22080

gccccccagg ggctttccac atgaccctgt caccccacag cccatccagc accaattcca    22140

gctctctgcc acccttcaaa ggagtgacag tgccctgctt cacctcccac tcacccctca    22200

acccagagca atctggctcc agtcttgcct ccttccccct aagtactcta gtcacagttc    22260

caaattcctc ctggtcataa agccaaatga agcttcctgg tcctcagcgg acttgccact    22320

tcagcagtac tggactctct cctcccagaa acctgtttcc ccttggctcc tggagcccac    22380

actctgctgg aatccttctg cctctctggc ctgtagcctg gccctctctc ccaacctgag    22440

gtccattctc tcctgctcct ccacaagatg ttgctccttc cattacttcc tccctctcaa    22500

ccaaagctcc ttcattagct ctttatcttc tggtttcttc ccctgggcag acgaatggat    22560

tcaagagcct gtggcccagc agcccagcac tccaggatct cagcacttca gcatcccagt    22620

accctagcat ctcaataccc cagcacccca gcaccatagt attccagcac cccattgtcc    22680

aagcatctca gcactccagc atcccagcac cccaacactc cagcagccca gaatctcagc    22740

accctagcac tgcagcatct caggacccca gcacttcagc atcccagcac actagtactc    22800

cagcatctcg gcaccccagc acctaggcat cccaacaccc agcaccccag cacttaagca    22860

tcccaccact acagtatctc aacactccag caccccagca ccatagtgtt ccagcacccc    22920

agcatcccaa caccccagca cttaagcatc ccaacacctc ggcatcccaa caccccagca    22980

ctgcagcatc tcagcacctt agcatcccag tgccctagca tctcaatgct ccagcacacc    23040

agtactacag tattccagca ccccagcact ccagcatctc agcactgcag cactgcagca    23100

ctccagcatc ccaaaatccc agcatcccaa caccccagca gaccagcaga ccagcatctc    23160

agcaccgcag catccaagga ctatcccagc atcccagcaa cccagcacct cagcatccca    23220

acaccccagc atttcagcat ggcaacaccc cagtacccca gcacttcagc accccagtat    23280

cccagcatct cagcgaccca gtatcacaaa acctcagcat cctagcaccc cagcacccca    23340

gcaccttagc accttagcat cccagcatct cagcgcctca gcatcttgat attctggctg    23400

aggtcagcgt ggtgtatcta gtcagggtcc taactttcac ttcgcaggga aatgctgctg    23460

gactgggtct catgttgggc tgaagctctc tagacccctt gaagacagca taaaagagct    23520

tggagacgct gggtgtcccc catggaagag ttcactctca tcctgctttg acaacagcct    23580

tctctggggt ccctcacggg cccctctttc ttactgcaag tttgtctctg agaagactgt    23640

gatgcagaag tcactcagct gcctgtggct cctgaagagc tgaaggtgga ggcctgtagg    23700

cctccctatg agaggcgcag aaaaaaccat gattgctagt ggggaggtgc tccctctaca    23760

acccactcca taatctgccc ccgcccagct ctgaggccag ccccagggga aaatgccaga    23820

tccccaggga ggtgtgtgag acctcagggg ctccctcctc ccttacagca ggctcaggcc    23880

cctgggggcc tcagggccaa ggtctgtggg taagctacta tctctcactt gtcctctagc    23940

cacaaaagcc agggagatct ggcaatggac atgaggttct gaagaagcac atatgactgg    24000

cttcctaatg cgtggttgtt cagtgattca ataaacacgc atgggccagg catggggaaa    24060

tagacaaaca tgatccccaa cctctcccag agtgaactgg gagggaggag tgttcatccc    24120

tcaggattac accagagaaa caaaccagca ggagatatat atggttttgg ggggtcaaga    24180

aagaggaaaa acctggcaag gcaagtccaa aatcatagga caggctgtca ggaagggcag    24240

cctggaacct ctcaagcagg agctgatgct gcagtccaca ggcagaattt cttcttcctc    24300

ggggaaatct cagctttgtt cttaaggcct ttcaactgat tggctgaggt ctgccccttc    24360

ccccacattc tccaggataa tcttccttac ttaaagtcaa ctattaatca cagctacaaa    24420

atcccttcac agctacacat agatcagtgt ttgattgacg aacagcccct acagcctagc    24480

caagttgaca cataaaacta accatcacag ggggacaaat gatgtaaaca catcaacaaa    24540

taaaacagta acaagttaag gtctatggaa aaaacacaga aggggcagag agaaagaaag    24600

caagaaggag agtcccagtt tgctagggct tgtgggaagt ggggagcagt tctctttagc    24660

taggatattt gggaaaggca tatctgaagg agtgatattt gagcttagat taaaagatgg    24720

gaaggagcaa gccatgcaaa gagctaggat gttccaagca gagacggaac agcaagtgca    24780

aatgtcagga ggaatagaag gaggctggtg ggtggggtcc agtgagcaag aggagggcag    24840

gcaggagagg ggatggggag gtgggcaggc ccagaccacc cagggccctg gagactatcc    24900

tgatccaaca agggaagcct tgagtcactt cagtgtccat gtggagaatg gacctcagac    24960

tgaatgaggg aggcagtaag gagggcctct acctccaggg cttcgccctg tggactgcgc    25020

atagacatct ccaactcaga aagtctgaac caaactttcc atagttcccc caagtctggg    25080

catcctccta ctcagtgaaa ggcagccatc acacctccct gccctgctcc cggatgcccc    25140

aaatcctctt ggtctccaag tccagaacct gagacttgtc cttgatgttt gtctttccct    25200

caccctttct gtattctggg aagatgggtt tttttccccc agatgaatct gtaaaacttc    25260

tgtgatcaca ataaaaattc tggcagtatt attttctgga acatgacaaa gtgattcaaa    25320

attatttatc tggaagacta caaaacaaga atagccagga aatttctaaa aagaaagaag    25380

aaggaggagg agaaagaagg aggaggaaaa ggaggagaag aagaaaagaa aaagaaccaa    25440

gaaagggttc tagctctacc aaatattaaa acatatcatg aagctattta aaacaatatg    25500

gttgtggata ctgaaaaaga tgtgaataaa gtggaaggaa aataaataga aatgcacatg    25560

gggattgaga ctgtgaaaaa ggcagcatct cacatcagtg agggatgttc aacacctggt    25620

gttgggaaaa ctggctagtc atttaaacca aacaactggg tcctctacct cactcctgac    25680

attaagatac atttagatga ttcaaagagt aagacagaaa aaataacacg tgaaaacact    25740

atcagaaaac aacgtgggcc aggtgtggtg ggtcacgcct gtaatcccag cactttggga    25800

ggccgaggca gacagatcac ctgaggtggg gagttcaaga ccagcctgac caacatggtg    25860

aaatcctgtc tctactaaaa atacaaaatt agctgagcgt ggtggcgcat gcctgtaatc    25920

ccagctactc aggaggccga ggcaggagaa tcacttgaac ctgggaggca gaggttgtgg    25980

tgagccgaga tcacgccatt gcactccagc ctgggcaaca agagtgaaaa tccatctaaa    26040

aaaaaaaaaa aaagccaagg tggatatttt tatagtatca gggtagatca agcttctcca    26100

atcatgacat gaaacccaga aaccataaaa gaaaagaatg ataaaattgc ccacgtaaag    26160

taaaaagctt gcacacagaa aaacaccata caggttacaa gatgagcagc aaaatcagag    26220

aaaaaacatt gcaattcagg acacacagag gctattgttc ctaatattta aaaataaaag    26280

tagtggattg tctacaaaaa gatgaagaca agaatttcag aaaaccaaat actgcatgtt    26340

ttcacttaca agtggaagct aaacactgag tacacgtgta cacaaagaat ggaaccatag    26400

gccaggcacc gtggctcacg cctgtaatcc cagtactttg cgaggccgaa gcgggcggat    26460

cacctgaggt gaggagttcg agaccatcct ggccaacatg gtgaaaccca gtctctacta    26520

aaaatacaaa aattagccgg gcgtggtggt gggtgcctgt aatcccagct actcgggagg    26580

ctgcggcagt agaatcgctt gaaccctgga ggtggacctt gcagtgagcc gagatcgcac    26640

cactgcactc cagcctgggc aacagagtga gactccatct caaaaaaaaa aaaaaggaat    26700

agaacaatag acactggggc ctacttgagg gaggagggtg aggatcaaaa acctgcctat    26760

caggtactat gcttattacc tgggtggtga aataatctgt acaccaaacc ccagtgacat    26820

gcaatttacc gatgtaacaa acctgcccat gtacccgctg aacctaaaat aaaagttgga    26880

aaaaaatata gaaattttct ttgtaatagc caaaaactgc aaacagccca ggtgtctatt    26940

agtagaatgc ataaacaaac tcgggcatgt tcatacaatg taaaactact catcaataaa    27000

aagtgatact tctcagcaat gaaaagaaac tagctactga taccagctac aacatggatg    27060

gatttcaagt gctttatgat gagagcaaga agccagacac aaaagtgtct atatatatat    27120

acagtatata tacgtatata tacacatata tacagtatat atatacatat acatgtatat    27180

atatactgta tatatactgt atatatatac acagtatata tatacatata tacagtgtat    27240

atatactgtg tatatataca tgtatatata ctgtgtatat atacatgtat atatactgtg    27300

tatatataca tgtatatata ctgtgtatat atacatgtat atatatgtat actgtatata    27360

tactgtatat atatatacac atatatacag tatatatata cagtatatac tgtatatata    27420

cagtatatac gtgtatatat acatatatac agtatatatg taaatataca tatatacagt    27480

atatatgtaa atatacatat atacatgtat atatatacac tatatatata catatatagt    27540

gtatatatac atatatacat gtatatattt actatatgat tccatttata taaagtgcca    27600

aaacagtcaa aaataatcta tgtggaaaaa atcaacaaag ggatcccccg ggctgcagga    27660

attcgatggc gcgccgacgt cgcatgctcc tctagactcg aggaattcgg taccccgggt    27720

tcgaaatcga taagcttgga tccggagagc tcgataacat ttaaatggat ctaccacatt    27780

tgtagaggtt ttacttgctt taaaaaacct cccacacctc cccctgaacc tgaaacataa    27840

aatgaatgca attgttgttg ttaacttgtt tattgcagct tataatggtt acaaataaag    27900

caatagcatc acaaatttca caaataaagc aatagcatca caaatttcac aaataaagca    27960

tttttttcac tgcattctag ttgtggtttg tccaaactca tcaatgtatc ttatcatgtc    28020

gagctaggat cccgcggccg cctactggtc ctcctggagg tagaacttgg tgaccatgaa    28080

ggactctttg ggcttgttgg tgaggctgac gggccggtct gcctcctgcg ccgtgcagag    28140

gaaccagcca gggcaggcgg cagactcgaa gctggtggtg gggccactgt ttgagcggat    28200

gaaggtgaag cgcttgttct cctccttgtt cttgctcagg tcagtgatgt taactgcctc    28260

caattggaac ctaatctcat caccagactt gacacaggcc aggcacagct tcctcccatg    28320

gagtcccagg aatagagcat caggctcaat gggcaccaca tctatcttct cttgtaattt    28380

agtatttgat tcttgcaagt atccagcaac tagttggtta ttcctcatgt agaaggtctt    28440

ctggttaaca tcccagattc tgaaggcttg catcttgcag ggtctcttcc ccaaagggtg    28500

gcaggctgtc tctgagtaga gcaagaaaag gaggagagag attaggtgtc tgacagaacg    28560

cctgcggatt tccataccgg tggatccatg gctctgtctc aggtcagtat aggagctttg    28620

atgtgaagtc agccaagaac agctgaacac tacttcctct gaggcccttt tataggaggg    28680

attgcttcct gtgaataata ggaggatatt gtccacatcc agtaaagagg aaatccccaa    28740

ctgcatccaa aaagttttct gggaatatcc actgctgcag gagtggaaag tccccagtgg    28800

aaagtcccca gtggaaagtc cccagtggaa agtccccagt ggaaagtccc cagaatttcg    28860

acggcgcgcc taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc    28920

agctcaatca gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa    28980

aaaatgacgt aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg    29040

cccagaaacg aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac    29100

gttacgtcac ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc    29160

ctaaaaccta cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc    29220

ctcattatca tattggcttc aatccaaaat aaggtatatt attgatgatg ttt           29273


<210>  4
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized human IL-1Ra

<400>  4
atggaaatct gcagaggcct gcggagccac ctgattaccc tgctgctgtt cctgttccac       60

agcgagacaa tctgccggcc cagcggcaga aagtccagca agatgcaggc cttccggatc      120

tgggacgtga accagaaaac cttctacctg cggaacaatc agctggtggc cggctacctg      180

cagggcccca atgtgaacct ggaagagaag atcgacgtgg tgcccatcga gccccacgcc      240

ctgtttctgg gaatccacgg cggcaagatg tgcctgagct gcgtgaagtc cggcgacgag      300

acacggctgc agctggaagc cgtgaacatc accgacctga gcgagaaccg gaagcaggac      360

aagagattcg ccttcatcag aagcgacagc ggccccacca ccagctttga gtctgccgct      420

tgccctggct ggttcctgtg cactgccatg gaagccgacc agcccgtgtc cctgaccaac      480

atgcctgacg agggcgtgat ggtcaccaag ttctattttc aagaggacga gtga            534


<210>  5
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  original human IL-1Ra

<400>  5
atggaaatct gcagaggcct ccgcagtcac ctaatcactc tcctcctctt cctgttccat       60

tcagagacga tctgccgacc ctctgggaga aaatccagca agatgcaagc cttcagaatc      120

tgggatgtta accagaagac cttctatctg aggaacaacc aactagttgc tggatacttg      180

caaggaccaa atgtcaattt agaagaaaag atagatgtgg tacccattga gcctcatgct      240

ctgttcttgg gaatccatgg agggaagatg tgcctgtcct gtgtcaagtc tggtgatgag      300

accagactcc agctggaggc agttaacatc actgacctga gcgagaacag aaagcaggac      360

aagcgcttcg ccttcatccg ctcagacagt ggccccacca ccagttttga gtctgccgcc      420

tgccccggtt ggttcctctg cacagcgatg gaagctgacc agcccgtcag cctcaccaat      480

atgcctgacg aaggcgtcat ggtcaccaaa ttctacttcc aggaggacga gtag            534


<210>  6
<211>  177
<212>  PRT
<213>  ArtificialSequence

<220>
<223>  human IL-1Ra protein

<400>  6
Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 
1               5                   10                  15      


Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 
            20                  25                  30          


Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 
        35                  40                  45              


Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 
    50                  55                  60                  


Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 
65                  70                  75                  80  


Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 
                85                  90                  95      


Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 
            100                 105                 110         


Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 
        115                 120                 125             


Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 
    130                 135                 140                 


Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 
145                 150                 155                 160 


Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 
                165                 170                 175     


Glu


<210>  7
<211>  29260
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  helper-dependent adenoviral vector-human Il-1Ra 
       gene

<400>  7
catcatcaat aatatacctt attttggatt gaagccaata tgataatgag ggggtggagt       60

ttgtgacgtg gcgcggggcg tgggaacggg gcgggtgacg tagtagtgtg gcggaagtgt      120

gatgttgcaa gtgtggcgga acacatgtaa gcgacggatg tggcaaaagt gacgtttttg      180

gtgtgcgccg gtgtacacag gaagtgacaa ttttcgcgcg gttttaggcg gatgttgtag      240

taaatttggg cgtaaccgag taagatttgg ccattttcgc gggaaaactg aataagagga      300

agtgaaatct gaataatttt gtgttactca tagcgcgtaa tatttgtcta gggccgcggg      360

gactttgacc gtttacgtgg agactcgccc aggtgttttt ctcaggtgtt ttccgcgttc      420

cgggtcaaag ttggcgtttt gatatcaagc ttatcgatac cgtaaacaag tctttaattc      480

aagcaagact ttaacaagtt aaaaggagct tatgggtagg aagtagtgtt atgatgtatg      540

ggcataaagg gttttaatgg gatagtgaaa atgtctataa taatacttaa atggctgccc      600

aatcacctac aggattgatg taaacatgga aaaggtcaaa aacttgggtc actaaaatag      660

atgattaatg gagaggatga ggttgatagt taaatgtaga taagtggtct tattctcaat      720

aaaaatgtga acataaggcg agtttctaca aagatggaca ggactcattc atgaaacagc      780

aaaaactgga catttgttct aatctttgaa gagtatgaaa aattcctatt ttaaagtaaa      840

acagtaactc acaggaaata ccaacccaac ataaaatcag aaacaatagt ctaaagtaat      900

aaaaatcaaa cgtttgcacg atcaaattat gaatgaaatt cactactaaa attcacactg      960

attttgtttc atccacagtg tcaatgttgt gatgcatttc aattgtgtga cacaggcaga     1020

ctgtggatca aaagtggttt ctggtgcgac ttactctctt gagtatacct gcagtcccct     1080

ttcttaagtg tgttaaaaaa aaagggggat ttcttcaatt cgccaatact ctagctctcc     1140

atgtgctttc taggaaacaa gtgttaaccc accttatttg tcaaacctag ctccaaagga     1200

cttttgactc cccacaaacc gatgtagctc aagagagggt atctgtcacc agtatgtata     1260

gtgaaaaaag tatcccaagt cccaacagca attcctaaaa ggagtttatt taaaaaacca     1320

cacacacctg taaaataagt atatatcctc caaggtgact agttttaaaa aaacagtatt     1380

ggctttgatg taaagtacta gtgaatatgt tagaaaaatc tcactgtaac caagtgaaat     1440

gaaagcaagt atggtttgca gagattcaaa gaaaatataa gaaaacctac tgttgccact     1500

aaaaagaatc atatattaaa tatactcaca caatagctct tcagtctgat aaaatctaca     1560

gtcataggaa tggatctatc actatttcta ttcagtgctt tgatgtaatc cagcaggtca     1620

gcaaagaatt tatagccccc cttgagcaca cagagggcta caatgtgatg gcctcccatc     1680

tccttcatca catctcgagc aagacgttca gtcctacaga aataaaatca ggaatttaat     1740

agaaagtttc atacattaaa ctttataaca aacacctctt agtcattaaa cttccacacc     1800

aacctgggca atatagtgag accccatgcc tgcaaaaaaa aaaaaattag ccaggcatgg     1860

tagcatgtac ctgtagtccc agctacttga gaggtgaggt gggaaaatca ctttagtgca     1920

ggatgttgag gctggagtga actgtgattg tgccactgca ctccagcctg gacaatagag     1980

caagaccttg tctcaaaaaa atgcattaaa aatttttttt aaatcttcca cgtaacacat     2040

cctttgccct catgtttcat aaggtaaaaa atttgatacc ttcaaaaaaa ccaagcatac     2100

cactatcata atttttttta aatgcaaata aaaacaagat accattttca cctatcagac     2160

tggcaggttc tgattaaatg aaatttcttg gataatatac aatattaaga gagactgtag     2220

aaactgggcc agtggctcat gcctgtaatc ccagcacttt gggaggctgg gtaacatggc     2280

gaaccctgtt tctacaaaat aaaaatatta gctgggagtg gtggcgcaca cctatagtcc     2340

cagctactca ggaggctgag gtggaaggat cgcttgaacc caggaggttg agactgcagt     2400

gaactgtgat cattctgctg cactgcaccc cagcctgggc aacagagacc ttgtctcaaa     2460

aaaaaaaaaa aaagagacaa attgtgaaga gaaaggtact ctcatataac atcaggagta     2520

taaaatgatt caacttctta gaggaaaatt tggcaatacc aaaatattca ataaactctt     2580

tccccttgac ccagaaattc cacttgaata aagctgaaca agtaccaaac atgtaaaaga     2640

atgtttcttc tagtacagtc ggtaagaaca aaatagtgtc tatcaatagt ggactggtta     2700

aatcagttat ggtatctcca taagacagaa tgctatgcaa cctttaaaat atattagata     2760

gctctagaca cactaatatt aaaagtgtcc aataacattt aaaactatac tcatacgtta     2820

aaatataaat gtatatatgt acttttgcat atagtataca tgcatagcca gtgcttgaga     2880

agaaatgtgt acagaaggct gaaaggagag aactttagtc ttcttgttta tggcctccat     2940

agttagaata ttttataaca caaatatttt gatattataa ttttaaaata aaaacacaga     3000

atagccagac atacaatgca agcattcaat accaggtaag gtttttcact gtaattgact     3060

taacagaaaa ttttcaagct agatgtgcat aataataaaa atctgacctt gccttcatgt     3120

gattcagccc cagtccatta ccctgtttag gactgagaaa tgcaagactc tggctagagt     3180

tccttcttcc atctcccttc aatgtttact ttgttctggt ccctacagag tcccactata     3240

ccacaactga tactaagtaa ttagtaaggc cctcctcttt tatttttaat aaagaagatt     3300

ttagaaagca tcagttattt aataagttgg cctagtttat gttcaaatag caagtactca     3360

gaacagctgc tgatgtttga aattaacaca agaaaaagta aaaaacctca ttttaagatc     3420

ttacttacct gtccataatt agtccatgag gaataaacac cctttccaaa tcctcagcat     3480

aatgattagg tatgcaaaat aaatcaaggt cataacctgg ttcatcatca ctaatctgaa     3540

aaagaaatat agctgtttca atgagagcat tacaggatac aaacatttga ttggattaag     3600

atgttaaaaa ataaccttag tctatcagag aaatttaggt gtaagatgat attagtaact     3660

gttaactttg taggtatgat aatgaattat gtaagaaaac aacaggccgg gcgggttggt     3720

tcacacgtgt aatcccagca ctttgggagg ctgaggcagg cagactgcct gagctcagga     3780

gttcgagacc agcctgggca acacggtgaa atcccgtctc tactaaaaat acaaaaaaat     3840

tagccgggtg tggtgacaca tgcctgtagt cccagctact tgggaggctg aggcaggaga     3900

atcacttgaa cctgggaggt gaaggttgca gtgagccaag aatgcgccac ttcactccag     3960

cctgggaaac agagcaagac tctgtctctg agctgagats gcrccacttc actccagcct     4020

gggaaacaga gcaagactct gtctcaaaaa aaacaaaaca aacaaacaaa aaaacaggct     4080

gggcgcggtg gctcacgcct gtaatcccag cactttggga ggccgaggcg ggtggatcac     4140

ctgaggtcag gagttccaga ccagccttgt caacatggtg aaacctcccc ccgccgtctc     4200

tactaaaaat acaaaaatta gccaggcgtg gtggcaggag cctgtaatcc cagctacttg     4260

ggaggctgag gcaggagaat cgcttgtacc cagaaggcag aggttgcact gagctgagat     4320

ggcaccattg cactccagcc tgggggacaa gagcgagatt tcgtctttaa aaaacaaaaa     4380

acaaaacaaa aaaccatgta actatatgtc ttagtcatct tagtcaagaa tgtagaagta     4440

aagtgataag atatggaatt tcctttaggt cacaaagaga aaaagaaaaa ttttaaagag     4500

ctaagacaaa cgcagcaaaa tctttatatt taataatatt ctaaacatgg gtgatgaaca     4560

tacgggtatt cattatacta ttctctccac ttttgagtat gtttgaaaat ttagtaaaac     4620

aagttttaac acactgtagt ctaacaagat aaaatatcac actgaacagg aaaaactggc     4680

atggtgtggt ggctcacact tgtaatccca gtgctttggg aggctgagac aggagagttg     4740

cttgaggcca ggagttcaag accgacatgg ggaatgtagc aagaccccgt ccctacaaaa     4800

aactttgtaa aaatttgcca ggtatggtgg tgcatacctg tagtcccagc tactcgggag     4860

gcggaggcag aaggaatcac ttgagcccag gagtttgagg ctgcagtgag ctacgatcat     4920

accacagcac tccagcgtgg acaacagagt aagaccctat ctcaaaaaca aaacaaaaca     4980

aaacaaacaa aaaaaaccac aagaaaaact gctggctgat gcagcggctc atgcctgtaa     5040

tcccagtatt ttgggaggcc caggtgggcg tatcacctga ggtcaggagt tagagaccag     5100

cctggccaac atggtgaaac cccatctcta ctaaaaatac aaaattagcc aggcatgtgg     5160

cacgcgcctg tagtcccagt tactggggag gctgaagcag gaggatcacc tgagcccggg     5220

aggtggaggt tgcagtgagc cgagatcaca ccactgcact ccagcctggg tgacacagca     5280

ataccctacc tcaaaataaa aaagaaaaag aaaagaaaag ttgctgtccc cgctacccca     5340

atcccaaatc caaacagcct ctctcatctc acagtaaggg ggaaaaatca cccaaaaaag     5400

ctaagtgatc ttttgaaaac ccaaactctt agaagtctaa gattattata gtcaactcat     5460

gaagtgtcat cataaaagat actctaatat tatttaagta gaaccacata ttggttgtct     5520

tggtatgtct agcccctggc atacaaaata tttaataaca ctgatatggt acctgtgatg     5580

tgaaaatgta ctatgagtac agctttataa atactatata tgtacctata tacagaaaaa     5640

aatacaacaa aatcataaaa gcacttatct ttgaaagagg agttacagca attttattta     5700

gttctttatt gctttgctat atattctaaa tttttttcaa tgaatatata tcacttttaa     5760

aaaaattcaa tggtctttct tataaattat ctttggcagc atgcgttttt atatatacat     5820

ataaaatgta tgggaaattt ttaaaggata cattaaatta aagcaaaata tacaaacaaa     5880

aaatcagaat acaaaaagat aaaaagattg ggaagggagg gagggagtaa ggaggaaggg     5940

tgggtgggta tagagaaata taccaaataa tggtaagaag tggggtcttg acactttcta     6000

cacttttttt aaataaaaaa aatttttttc tctctctttt ttttttttag agacgaagtc     6060

tcgctatgtt gcccaggctg gtcttgaact cctgggatca agagatcctc ctgcctcagc     6120

ctcccaaggt gcttggatta caggtgtgag ccaccacgcc tggtcacttt ctacacttta     6180

atatatatat tttttcattt tcaatgtcat ttttattagt taatttataa tacccattca     6240

ccattatatt caaagtctat ttgaagaaat aaaccagaaa gaatgaaata ctctagctca     6300

catgctattc aatactaaat tacctttcaa atcacattca agaagctgat gatttaagct     6360

ttggcggttt ccaataaata ttggtcaaac cataattaaa tctcaatata tcagttagta     6420

cctattgagc atctcctttt acaacctaag cattgtatta ggtgcttaaa tacaagcagc     6480

ttgactttta atacatttaa aaatacatat ttaagactta aaatcttatt tatggaattc     6540

agttatattt tgaggtttcc agtgctgaga aatttgaggt ttgtgctgtc tttcagtccc     6600

caaagctcag ttctgagttc tcagactttg gtggaacttc atgtattgtc aggttggccc     6660

gtaatacctg tgggacaact tcagcccctg tgcacatggc caggaggctg gttgcaaaca     6720

ttttcaggta ggtggaccag gacatgcccc tggtcatggc caggtggagg catagtgcta     6780

tacagcaggc agaagtcaat attgatttgt ttttaaagaa acatgtacta ctttcataag     6840

cagaaaaaat ttctattctt gggggaaaag attatgccag atcctctagg attaaatgct     6900

gatgcatctg ctaaaccttc acatatcaga acatatttac tatagaaaga atgaaaatgg     6960

gacatttgtg tgtcacctat gtgaacattc caaaaatatt ttacaacaac taagtatttt     7020
     
ataaatttta tgaactgaaa tttagttcaa gttctaggaa aatacaaacc ttgctagata     7080

ttataaaaat gatacaatat atattcattt caggctcatc agaatatatc tgttatcact     7140

tgacaagaat gaaaatgcac cattttgtag tgctttaaaa tcaggaagat ccagagtact     7200

aaaaatgact tcttccttga agcttactca ccaacttcct cccagttact cactgcttct     7260

gccacaagca taaactagga cccagccaga actccttgaa atatacactt gcaacgatta     7320

ctgcatctat caaaatggtt cagtgcctgg ctacaggttc tgcagatcga ctaagaattt     7380

gaaaagtctt gtttatttca aaggaagccc atgtgaattc tgcccagagt tcatcccaga     7440

tatgcagtct aagaatacag acagatcagc agagatgtat tctaaaacag gaattctggc     7500

aatataacaa attgatttcc aatcaaaaca gatttacata ccatacttat gtcaagaagt     7560

tgttttgttt tattgcatcc tagattttat ttttttgatt tatggtttac tttaagcata     7620

aaaaatttgt caatacaact cttcccaaaa ggcataaaca aaaattcata aaacttgcat     7680

cacttgagat acttcaggta tgaattcaca actttgttac aacttactat atatatgcac     7740

acatatatat atatttgggt atattggggg ggttctaatt taagaaatgc ataattggct     7800

atagacagac agttgtcaga acttggcaat gggtacgtgc aggttcatta taccaagtct     7860

acttgtagtt gttcaaaatg tatcataata caaggccggg cgaggtsgct cacgcctgta     7920

atcccagcat tttgggaggc taaggcagga ggattgcttg aggtcaggag tttgtgacca     7980

gcctgggcaa cagagcaaga ccctgtctcc aaaaagaaaa aaaataattt tttacaaaat     8040

aaaaacaaaa tgtatcatca gacgaaatta aataagaggc aattcattta aatgacaact     8100

tttcccagct tgacatttaa caaaaagtct aagtcctctt aattcatatt taatgatcaa     8160

atatcaaata ctaatttttt tttttttttt ttttttgaga cggagtctcg ctctgtcgcc     8220

caggctggag tgcagtggcg cgatcytggc tcactgcaag ctccgcctcc cgggttcacg     8280

ccattctcct gcctcagcct cccgagtagc tgggattaca gacatgcgcc accacgcccg     8340

gctaattttg tatttttagt agagatgggg tttctccatg ttggtcaggc tggtcttgaa     8400

tttcccacct caggtgatct gcctgcctca gcctcacaaa gcagtagctg ggactacagg     8460

cacccaccac cacacttggt taattctttt gtattttttt tgtaaagacg ggatttcacc     8520

atgttagcca ggatggtctc gatctcctga tctcatgatc cgcccgcctc agcctcccaa     8580

agtgctggga ttacaggcgt gagccacccc gcccggccat caaatactaa ttcttaaatg     8640

gtaaggaccc actattcaga acctgtatcc ttatcactaa tatgcaaata tttattgaat     8700

acttactatg tcatgcatac tagagagagt tagataaatt tgatacagct accctcacag     8760

aacttacagt gtaatagatg gcatgacatg tacatgagta actgtgaaca gtgttaaatt     8820

gctatttaaa aaaaaagacg gctgggcgct gtggctcatg cctgtaatcc cagcactttg     8880

ggaggccaag gcaagttgat cgctcgaggt caagagttcg agaccagcct ggccaacgtg     8940

gtaaaacccc gtctctacta aaaatacaaa aaaaaaatta gccaggcatg gtggcacagg     9000

cctgtaatcc cagctactag ggaggctgag acatggagaa ctgcttgaat ccaggaggca     9060

gaggttacag tgagccgaga tcataccact acactccagc ctgagtgaca gagcgagact     9120

ccgtctaaaa aaaaaaaaaa aaaaaaagat acaggttaag tgttatggta gttgaagaga     9180

gaactcaaac tctgtctcag aagcctcact tgcatgtgga ccactgatat gaaataatat     9240

aaataggtat aattcaataa ataggaactt cagttttaat catcccaaac accaaaactt     9300

cctatcaaac aggtccaata aactcaatct ctataagagc tagacagaaa tctacttggt     9360

ggcctataat cttattagcc cttacttgtc ccatctgata ttaattaacc ccatctaata     9420

tggattagtt aacaatccag tggctgcttt gacaggaaca gttggagaga gttggggatt     9480

gcaacatatt caattataca aaaatgcatt cagcatctac cttgattaag gcagtgtgca     9540

acagaatttg caggagagta aaagaatgat tataaattta caacccttaa agagcttata     9600

gctgggcgtg gtggctcatg cctgtaaatc ccagcacttt gggaggctga ggcgggtgga     9660

tcacctgagg ccagaagttc aagaccagcc tagccaacat ggcgaaaccc tgtctctaca     9720

aaaaatacaa aaattagccg ggtgtggtgg cacgtgcctg tagtcccagt tacttgggag     9780

gccgaggcag gagaatcgct tgaacctagg aggtggaggc tgcagtgagc cgagattgtg     9840

ccactgcact ccacttcagc ctgggcgaca agagcaagac tccgtcacaa aaaaaaaaaa     9900

aaaaaaaaag cttaaaatct agtgggaaag gcatatatac atacaactaa ctgtatagca     9960

taataaagct cataatctgt aacaaaatct aattcgacaa gcccagaaac ttgtgattta    10020

ccaaaaacag ttatatatac acaaaaagta aacctagaac ccaaagttac ccagcaccaa    10080

tgattctctc cctaagcagt atcaagttta aagcagtgat tacattctac tgcctagatt    10140

gtaaactgag taaaggagac cagcaccttt ctgctactga actagcacag ccgtgtaaac    10200

caacaaggca atggcagtgc ccaactttct gtatgaatat aagttacatc tgttttatta    10260

tttgtgactt ggtgttgcat gtggttatta tcaacacctt ctgaaagaac aactacctgc    10320

tcaggctgcc ataacaaaat accacagact gagtgactta acagaaactt atttctcaca    10380

gttttggagg ctgggaagtc caaaattaag gtacctgcaa ggtaggtttc aatctcaggc    10440

ctcttctttg gcttgaaggt cttctaactg tgtgctcaca tgacctcttc taacaagctc    10500

tctggtgtct cttttttttt ttttttcttt tttgagacag agtctcactc tgtcacccag    10560

gctggagtac agtggcacaa tctgggctca ctgcaacctc caactcccgg gttcaagtga    10620

ttctcatgcc tcaccctccc gagtagcttg gatgacagga gcccgctacc acacccagct    10680

aatttttgta tttttagtag agatggtgtt tcactacatt ggccaggctg gtctcaaact    10740

cctgacctcg tgatccaccc accttggcct cccaaagtgc tgggattaca ggtgtgagcc    10800

actgcgcccg tcctggtgtc ttttcatata agggcactaa tccaatcaga cctgggccca    10860

accctcccga cttcttctaa ctgtaattac cttccaaagg ccctgtctcc aaataccatc    10920

acactggggg ttaggacttc aaaaaaggta tggggggggt gtgggaggac ataaatgctc    10980

agtccataac aagcacccaa cataaaaatg gctagaacag atcacaaaaa aaaggtcctg    11040

tatggctttg gggaagggct caaccccaaa atatctgaga gctctggagg ggcctagaag    11100

tggtaaatga atgaaaacgt ggttactctc cagatctgcc tttcccaaat atggccattc    11160

ttggctgaat cagaaatcaa aggacaggtt attaattact agctctaagt tacttaccat    11220

ttgctgagac agttcagaaa tctgactgca tctcctcaga gatctagaac acagttctca    11280

aattctaact tacttgtgat atacttgtga atgataaaaa tcgctacagg tacttttatt    11340

aatctgaaag agtattgaga aattaccttt cattctgact tttgtctgga atgaaaatca    11400

atacttttgc tataatcgat tactgaaata attttacttt ccagtaaaac tggcattata    11460

atttttttta atttttaaaa cttcataatt ttttgccaga ctgacccatg taaacataca    11520

aattactaat aattatgcac gtcacatctg taataatggc cttcatgtaa acatttttgt    11580

ggtttacaca taaaatctct aattacaaag ctatattatc taaaattaca gtaagcaaga    11640

aaattaatcc aagctaagac aatacttgca acatcaattc atcatctgtg acaaggactg    11700

cttaagtctc tttgtggtta aaaaggaaaa aaaaaaaaaa gacatgttgg ccagatgcgg    11760

tggctcacac ctgtaatccc agcactttgg gaggctgagg tgggcggatc acccctggcc    11820

tgcccaacat ggtgaaaccc cgtctctact aaaaacacaa aaattagctg ggcgtggtgg    11880

cgggcgcctg taattccagc tactcgggag gctgaggcag gagaattgct agaacccagg    11940

aggcagagat tgcagtgagc tgagattgca ccattgcact acagtctggg caacaaaagt    12000

gaaactccat cttaaaaaaa aaaagacaat gttcgtgggt ccaaacaaga cttaatggaa    12060

gtgagtctaa aaatgagcta tgtgggccag gcgtagtggc tcccacctgt aatcccagca    12120

ctttgggagg ccgaagcagg cagatcatga ggtcaggaga tggagaccat cctggccaac    12180

acggtgaaat cctgtctcta caaaaattag ctgggcgtgg tggtgcctgc ctgtaatccc    12240

agctactcag aaggctcagg caggagaatc gcttgaacca gggagtcggt ggctagagtg    12300

agccgagatt gcatcactgc actcctgcct ggtgacagag caagactcca tctcaaaaaa    12360

aacaaacaaa aataaaagat aaaaatgagc tatgtgaatt aaaagaggta taacaataga    12420

taaaccatat tttatttaat tcctagtaat gagtaatatt tccaaacttc tggaatgggc    12480

agaaattgct agttggcata tttttacctt ttatattcag atacattaaa attctcaaaa    12540

aaaaacacct caaagcagat gatccgccat ctccttggat aatttgtgtt aactcaggat    12600

aacagaaaac caaaattatg agttactgat gcaatattcc taaatgtaaa aataattaaa    12660

gctaatagta gattcatctt ccaatttcat atcagtctta caaataaact acatatataa    12720

cttgcttgcc ttcccttctg agggataaag ctgttagaag aattaaaatc agcattcttg    12780

actattcaac caagggaggg ataaattatt actcattcta gggacatggg ctcataacta    12840

ctacatgtgt aaggacatga atttacccaa tattacaatt tttcctttta ttagtgtgta    12900

cagtggaaga atagacatgt tcactctgga caaaaaaaaa attatactta tcagttatca    12960

gaagcacaat gctgaagaca gtagttccat aacaatttga agtatgtgat cgaactagta    13020

gattatctta gtagtagtga attattgtaa atgttagtaa tttggcagcc actgggcaga    13080

aaaataagaa ttgaggctca atattgatat taatggtggt gattgacaca taaattttat    13140

caagtctaca caatataaaa ttacagaaag gtagaagagt ataccagtac aacttcaaca    13200

tatcttcact acaagggagt aaaatgacat ggcctagtta ctatctaatg aactgcagaa    13260

aactaaaaga aaactccaag gcaactcttc tctgctgatc tggttggtcc ttttcctacc    13320

ttttgcaata cccagataca aacaatggat agaaaacaaa gtagacttgt agtatgcagg    13380

tcacagtgct aaattcacag aaagaaaccc ctgaactgaa ctgctctatt tcctggtggt    13440

cacaaagagt aattctggtt tacacctaca gattgatgtc aatctacacc ctgttgataa    13500

cagtgtggcc aaggacaaaa aaaaggtgct ccgttttacc aattctgtaa aaaattattg    13560

gcagggtaag ctcggctagg gcaggattac atttctagga ctaccatccc cgaaatttag    13620

aagatattat atccacataa agcatatctt tcacattaat ttgcaaaaat ctaaaagctt    13680

tttcttagct caagtgtgtc caagtttacc ctggcagttt aaaacgatag ttacaagcag    13740

catgggttgt atcagacaca tttgagggcc aatttcatgt aagtgatatt gggcaagtta    13800

cttcaactat ctgtgcctcc aaggtcatac tagtgtttat ttacctaaag ggtacctgtt    13860

atgtaacttt agggtgttta cattagataa tgcctgcaaa atatttactt caacgcctaa    13920

aacatagtta agtattcaat aaatacctac tattgtcact actaacttaa aagtttagag    13980

attaagagca gaatctgggg tgagacaaac ttaggttcaa atcctagtat tgttgggtaa    14040

tcttgggcaa gttacttaac ctctctgatt tgtgtaattt aaaaaattag ttaatataca    14100

taacagggct tagaagagta tctagcacat agcaccattt aagcatttgt tattgctaac    14160

atgcaaacaa tttaagggaa agaaattttt taaaaaggaa gagggatttg caaactaaaa    14220

acaatgagta tcttatgttc aaagaaaact aacaaacagc cagctctagc aataattaaa    14280

ttcactatat actggggcag gcatcacacc ccaaagctaa aagcgtctac ctaggccagg    14340

cacggtggct catgcctgta atcccagcac tttgggaagc agaggcgggc agatcgcttg    14400

agctcaggag ttcaagacca gcctggacaa catggcaaaa caccatctct acaaaaaata    14460

caaatattag gccgggcgca gtggctcacg cctgtaatcc cagcactttg ggaggccaag    14520

gcgggtggat cacctgagat caggagttcg agagtagcct ggccaacatg gtgaaacctc    14580

gtctctatta aaaatacaaa aaattagcca ggcatggtgg caggcgcctg taatcccagc    14640

tactcagggg gatgaggtag gagaatcgct tgaacccggg aggcagaggt tgcactgagc    14700

cgagatcatg ccactgtact ccagcccggg caacaagagc gaaactccat ctcaaaaaat    14760

aaataaataa ataaataaaa taaagtacaa atattagcca gggatggtgg tgcgcacctg    14820

tagtcccagc tacttgggag gctgaagtgg gagaatcccc tgagcctggg gagaatcacc    14880

cgagcccggg aagtcgaggc tgcagtgagc agtgattgtg ccactgcact ccatcctagg    14940

tgacagagtg agaccctgtc tcaaaaaaaa gaaattggca gaattaagta agttgatgtt    15000

tagagatgaa aaatcaacat tttttcctca gcaactgaat aaaaacaaca gccactacca    15060

tttttttgag tacctatttg tagcctattt tttaactggt attactcgag agagagagag    15120

ctaggttcga gacagagctc cttctcttaa taactgtatg acctagggta tgtctgttag    15180

cctctctgag gcttcaaagg ttcctcatct gtaaaatggt aataatcata ccattgctac    15240

agggctgttt tgaagactaa ttaggactat gtaagtaaac atgatgatgg ctattattac    15300

tgttccccgc caggggccat gcaagggttg ctgattcaca tagactgtct tataatcctc    15360

tcaataactc caagaggtag ccagcacctc agatatacat aaaatgactt aagcccagag    15420

aggtgaagta agttgcccac agccacacaa ctagtaaata gcccaaacaa gctggattcc    15480

cagttagact ccgttaatag cactgctctt taccttaagt cattacaatg cctaatatga    15540

aatagaatcg cttctttctt agggttcaag tggttaatta tttaatgtat tcattcaaca    15600

aaccatcatc gaggacctct tacaagccaa gtactgtgct aagtgctaga gttacggcgg    15660

tgattcctgc ccttaaaaag ttttagtggg agaaacaaca ggtaaccagg tcattgccaa    15720

aacaacaaaa ataatcataa taaagcaggc taaagcatat ttaactggcc ggggttttga    15780

ctattttagc aagcatgatc agaacggttg aggagggagg ccagcagctt ggccggttca    15840

acaaacaaga aaaaaccagt gagggtggag ctaagatacc agaggctgat tacggttaag    15900

aatgttcttg aaggtaagga ccagattctc attttctata tcctggggca tcggtcagca    15960

tggaatctgg attctagcac atgtgaattt cggcttgaaa tgacctaatg ccttttccct    16020

agttccttcg tgtgtcaaat acgcatggtt accgctacca gagctgtagt ggggcttcaa    16080

tgaggccatg agcatctcca taaagatgaa ctacagtgtg tgcaaaacta aaggcaaaac    16140

ctggtcccca cacgccctcc caggtggtcg ctttccgtgc cgaggcccct ccagaggtgc    16200

cccgagaacc tcaccatcgc accccaaact tccagggaag ggcctctccc gagaaagccc    16260

ccacgccccc accccgcgcc atcattcccg aatctgccct cggcccctcc ccgcagcacg    16320

ctcgcaggcg gcacatgtca accaaaacgc catttccacc ttctcttccc acacgcagtc    16380

ctcttttccc agggctcccc cgaggaggga cccaccccaa accccgccat tccgtcctcc    16440

ctgccgccct cgcgtgacgt aaagccgaac ccgggaaact ggccgccccc gcctgcgggg    16500

ttccctgggc ccggccgctc tagaactagt ggatcccaat tgaaggcctg gtctaaatga    16560

ctccaaaatc accacttaat tcaagagact gatttccctg agtcaggccc cttaaagcag    16620

ctatttcaat gggacaggga aacaacccta ggatctggat tagaatcact tgggggctgc    16680

cacaccccca gggctctgat cctgcccttc tcccacacgc acattcacat actgctgcag    16740

tgaccttcca tttctaatgg gttcctgggc catctgtcag gtatagggaa tggaaaaggg    16800

gttggggagg ctctgcttca gaaagtttgt gtcaggggct cccagagcct ccacagatag    16860

atagcagggg tccccaccct accatggcag ctataaatgt gatcaacatt tattggccta    16920

ggatacagca gttagcaaaa tgcctgatgt agttcccact ccgtggaggt tgcaggctag    16980

ccaagaagtc atgagttcag caacccttac gcaccagtgg gatgagattg gaccaggccg    17040

agggtagtct tgggaacact cagcatttgt ctgagggcca gaagaggctg cttgccctca    17100

gacaggaggt cagcatcttt attgtagccc atgacacctc tacaccattg ctcttctggt    17160

cttatggaag acatctttgg gcctgataac agcggagtct gtgtcccact tgtccaggct    17220

ggagtgccac atcaggcaca ctccagttgc agggacagca cagacaagtt tcaggaaggc    17280

tggtggcctc caggaggtta accttataag gccagattgt aacctagttg aaaaacatac    17340

acatgccatg ataataaaag aacctaggca ccattacaag agaaaaaatc atttttgtag    17400

atacgagcat ggattcttgg gtgggtcaga cacactgggc ttgtgctctg actgcactgt    17460

ctcccctacc tgaccttggg taaaccataa gactgctgca tgactcagtg tccaccccaa    17520

aaaagtaccg gtagatattg gccacagtag atatcagcta gagtggactc tcatgacaat    17580

gaggggagat gtattcccca tcttaggcac ctgggactct accttccatc ttctgctccg    17640

tgtctctcca tccccaggct cttcagaact cagggagtcc agaatgtcag ctcccagatt    17700

tcagccttca gaaaggaaac ccattaccgt tcagttgaac aaatgttgtc tgagccccag    17760

atctgggctc agaggccatc taggctatga gacaagaggg gaacaaagca ccgtctgcac    17820

tcactcacca cactcacttg ctgtcccagg tcacatccat cgggtagaga atctaagagg    17880

ctgagctagc tcccgccacc agcccagccc accccacctg gccccttcct tccttctaca    17940

aaatatgcac cacctgtcaa agggtgggca gtgccaggcc tgcatacaga gcactgagtg    18000

taaaagcaga catggaccct gacctccagg agcttccaat tttcttgaag agacaaatca    18060

gctggcattt cagtccagtg tgatctgctc ttggtgagca cagacctagg gagttggggc    18120

agcttcccag aagaactgca gtccaggctg agggcagaga aatgagggga atggcgagga    18180

attggggagc aggggggagc tcagtagaga gccaagggcg ggaggtgaga agtccgtgtt    18240

gggccaggag ctaccctccg gtggccacag ccgaagtcga ggatgccttt ggaactcatc    18300

cccacttctc tctttctgta tgtagccgtc caagaacaag tcacctccaa gtgtagccgg    18360

atcaaggcaa gccccccatc tagcaagcac ttgatgccac ccagaactgg gcttcttcag    18420

aacaatctga gtccaggaat gatcccactc accaggcacc agagctgcga gggcatggga    18480

gtgatctcac caactctggg gaagcggcaa ggaattttca cctccagccc ccagtgtccc    18540

atcctctcac actcaggcca gactcccctg ggcagacttg actctgtctg ccagcatatg    18600

cagagcccca aggccacccc accagaagtg cccctgcctg ggttctgtcc cagctccctg    18660

ggcacccagt ccttgagtcc ccaccagctc agacggccta gtgtgccaag aatgcccact    18720

gcgttcaaca atgctgcatg ggtcacagcg gcagcagctg tgaccacagc agtttcgggg    18780

aaaacacccc tcagccaagt ggataatagc gttcagcagc actcaccttc tggccaggcc    18840

tgccttcaga ggccatctga ttgggaggca caagtgcccg ctgcgatggg aacacaagtg    18900

cccctggcca acaaccccag cttcagcctg ctgggcagcc agagcctcag gcagagcccg    18960

gtacagggcc cggtgcctgt agcaaacacc accaagttcc tccagcaggg tatggccagc    19020

tttagtcccc tgagccccat acagggcatc gagccaccaa gctatgtggc tgctgctgcc    19080

accgctgctg ctgcttctgc cgttgctgcc agccagttcc caggtccgtt cgacagaacg    19140

gatattcccc ctgagctgcc acctgccgac tttttgcgcc agccccaacc cccactaaat    19200

gatctgattt cgtcacctga ctgcaatgag gtagatttca ttgaagctct cttgaaaggc    19260

tcctgtgtga gcccagatga agactgggtg tgcaacttga ggctgatcga cgacattttg    19320

gaacagcatg ctgctgctca aaatgccaca gcccagaatt ctgggcaagt cacccaggat    19380

gctggggcac tttaaatctg agcaggatgc ccatagaaac ccccatggtg acatcactct    19440

aggaagtggt gtcgatccat acccgcagtt gtctcccgtt acaatttgag tggtgttgtc    19500

agcccatgct tatccctctc tctacctgtg acaaaatgga aagctggtga tttttcaagc    19560

tacgtgtaca tatttgaaaa ttttgtaaat ggttttccta aacattaatg acagaagtat    19620

ttatacttca ttttgtgact ttgtaaataa agcgacggct tttgtttcag tagagttgtg    19680

tttactatgc attgttttgt gtttattata caatgttaca aatatgcaga ccgtgttgtt    19740

tgctccagtg ataccttgtt aagctaggtg gctgagtcgc ttatggtttt aatgcaatga    19800

gcaatgtgga tatgaccaag agttgttgtg caagttgaca aatgccaaat agaaaaccac    19860

ttggccattt atttctatgt tcactaaaaa tcctattgcc ttgtgtgatt cttaatctct    19920

tttgcgaacc tttcagtctc cgctagctct ttcctaatga gctttacagc agaagctgtt    19980

ttatcgttaa gtgccccaca gagacacttt accaggaggc tgggagagtt ctccagattt    20040

gggagaggcg cagagacagt gtgtgagccg agccctgtct cagcaatcca cctggaggag    20100

ctagagtatc ctcctccctt taccattcag accgagagaa aaagcccagc ttgtgtgcac    20160

cctcgtgggg ttaaggcgag ctgttcctgg tttaaagcct ttcagtattt gttttgatgt    20220

aaggctctgt ggtttggggg ggaacatctg taaacattat tagttgattt ggggtttgtc    20280

tttgatggtt tctatctgca attatcgtca tgtatattta agtgtctgtt atagaaaacc    20340

cacacccact gtcctgtaaa cttttctcag tgtccagact ttctgtaatc acattttaat    20400

tgccacctcg tatttcacct ctacatttga aatctggcgt ctgtttcaag ccagtgtgtt    20460

ttttcttcgt tctgtaataa acagccagga gaaaagtgcc tctatgtttt tatttttcaa    20520

gggagtattc agtacctaca aacccaagtc aggaagcctg ctagtggctt tggttctttc    20580

agaggctgct cgatgccttg tgtgtcagaa agaaagattc agcagttttg catcatggca    20640

aagaagcctg ttattttggg gctcagcccc tcattttata gaggatgaaa cagaggggga    20700

tgggaggtca caaagacaac tgccccggga gcaggtgtgg gggagacttg ccctgagggt    20760

ctagacgctc tgcaccaccg tcctgtctcc cttgctgaag accacacatg cccttctttg    20820

accagaccct gccacctgat aggccaggac ctggtaggcg ggtacccagg tttcatggat    20880

ggaaccacat ctccccaaaa gtggggaggt agctactggg atgcacgcct cccgccatgt    20940

gctataggag agcagctgaa gcaacagttg ggatcagatg tagtcacaat tgaatgcatc    21000

atcacattta tccctctaag tggctgggag agttgatatc ctcatcccta aggtacaaaa    21060

tgttccaatt tgatcagtgg ctttcaggag ctgagaaagg catgtgctct gaggcagagc    21120

tgttatgtcc cgcagagcct aaaaatgctc taagaacatg ctccctgcca aaattctcaa    21180

tggctgtgac aagggacaac gatcgaccaa tgggggtgga agcagacctc cgcagtccag    21240

gggccagagc taggacagag gggtcggaga aagagtcatt ttcccaacac tccagctctt    21300

ggccagtcct cacacagtcc cctcctgctt cctgctgaga gagatatcct cataggtctg    21360

ggtaaagtcc ttcagtcagc tttcattccc tgtcaccaac tttgtctctg ttctccctgc    21420

ccgtctcagg cagcactcct caggaaacct ctccaagagc cagcctcact gcagcgccca    21480

ctattgtccc tctgcctcaa gtgtcccatc catgccaggc cccaggcagg ctgcagcttt    21540

ccctcagggc cacaccaaag cacttgggct cagctgtgct gtccccctcc atcactgagc    21600

tcaggggcag caggggtggg gtgccaggag gcccattcac ccttctctgg ctctgtgttg    21660

gacccacctg cccagccact gctgcttaga acctacccgc tgggaaaatg aagccctccc    21720

ggaggggcca cctcaacctg agagcctcac ggatcacagt tgtccccact cagctctgcc    21780

agccctcaga gacccataga taaaagctga gcttggctcg cagagctggt tccatcttcc    21840

attcccagag ggttcaactt cctaccccaa ccacacaggg aacctcaagg ctgagccagt    21900

gtgggctgca gtgcagacca gcttcctgga cacgtcctgc cacctgaccc caggctggcc    21960

tcactgcccc tggcactcct gaccctatcc tcattcctcc tggcagtgcg tgttctgcca    22020

ttccgctttc ccttagctgt cctctcactg tactgtcagc ttctcctttt ccaggtgccc    22080

cccaggggct ttccacatga ccctgtcacc ccacagccca tccagcacca attccagctc    22140

tctgccaccc ttcaaaggag tgacagtgcc ctgcttcacc tcccactcac ccctcaaccc    22200

agagcaatct ggctccagtc ttgcctcctt ccccctaagt actctagtca cagttccaaa    22260

ttcctcctgg tcataaagcc aaatgaagct tcctggtcct cagcggactt gccacttcag    22320

cagtactgga ctctctcctc ccagaaacct gtttcccctt ggctcctgga gcccacactc    22380

tgctggaatc cttctgcctc tctggcctgt agcctggccc tctctcccaa cctgaggtcc    22440

attctctcct gctcctccac aagatgttgc tccttccatt acttcctccc tctcaaccaa    22500

agctccttca ttagctcttt atcttctggt ttcttcccct gggcagacga atggattcaa    22560

gagcctgtgg cccagcagcc cagcactcca ggatctcagc acttcagcat cccagtaccc    22620

tagcatctca ataccccagc accccagcac catagtattc cagcacccca ttgtccaagc    22680

atctcagcac tccagcatcc cagcacccca acactccagc agcccagaat ctcagcaccc    22740

tagcactgca gcatctcagg accccagcac ttcagcatcc cagcacacta gtactccagc    22800

atctcggcac cccagcacct aggcatccca acacccagca ccccagcact taagcatccc    22860

accactacag tatctcaaca ctccagcacc ccagcaccat agtgttccag caccccagca    22920

tcccaacacc ccagcactta agcatcccaa cacctcggca tcccaacacc ccagcactgc    22980

agcatctcag caccttagca tcccagtgcc ctagcatctc aatgctccag cacaccagta    23040

ctacagtatt ccagcacccc agcactccag catctcagca ctgcagcact gcagcactcc    23100

agcatcccaa aatcccagca tcccaacacc ccagcagacc agcagaccag catctcagca    23160

ccgcagcatc caaggactat cccagcatcc cagcaaccca gcacctcagc atcccaacac    23220

cccagcattt cagcatggca acaccccagt accccagcac ttcagcaccc cagtatccca    23280

gcatctcagc gacccagtat cacaaaacct cagcatccta gcaccccagc accccagcac    23340

cttagcacct tagcatccca gcatctcagc gcctcagcat cttgatattc tggctgaggt    23400

cagcgtggtg tatctagtca gggtcctaac tttcacttcg cagggaaatg ctgctggact    23460

gggtctcatg ttgggctgaa gctctctaga ccccttgaag acagcataaa agagcttgga    23520

gacgctgggt gtcccccatg gaagagttca ctctcatcct gctttgacaa cagccttctc    23580

tggggtccct cacgggcccc tctttcttac tgcaagtttg tctctgagaa gactgtgatg    23640

cagaagtcac tcagctgcct gtggctcctg aagagctgaa ggtggaggcc tgtaggcctc    23700

cctatgagag gcgcagaaaa aaccatgatt gctagtgggg aggtgctccc tctacaaccc    23760

actccataat ctgcccccgc ccagctctga ggccagcccc aggggaaaat gccagatccc    23820

cagggaggtg tgtgagacct caggggctcc ctcctccctt acagcaggct caggcccctg    23880

ggggcctcag ggccaaggtc tgtgggtaag ctactatctc tcacttgtcc tctagccaca    23940

aaagccaggg agatctggca atggacatga ggttctgaag aagcacatat gactggcttc    24000

ctaatgcgtg gttgttcagt gattcaataa acacgcatgg gccaggcatg gggaaataga    24060

caaacatgat ccccaacctc tcccagagtg aactgggagg gaggagtgtt catccctcag    24120

gattacacca gagaaacaaa ccagcaggag atatatatgg ttttgggggg tcaagaaaga    24180

ggaaaaacct ggcaaggcaa gtccaaaatc ataggacagg ctgtcaggaa gggcagcctg    24240

gaacctctca agcaggagct gatgctgcag tccacaggca gaatttcttc ttcctcgggg    24300

aaatctcagc tttgttctta aggcctttca actgattggc tgaggtctgc cccttccccc    24360

acattctcca ggataatctt ccttacttaa agtcaactat taatcacagc tacaaaatcc    24420

cttcacagct acacatagat cagtgtttga ttgacgaaca gcccctacag cctagccaag    24480

ttgacacata aaactaacca tcacaggggg acaaatgatg taaacacatc aacaaataaa    24540

acagtaacaa gttaaggtct atggaaaaaa cacagaaggg gcagagagaa agaaagcaag    24600

aaggagagtc ccagtttgct agggcttgtg ggaagtgggg agcagttctc tttagctagg    24660

atatttggga aaggcatatc tgaaggagtg atatttgagc ttagattaaa agatgggaag    24720

gagcaagcca tgcaaagagc taggatgttc caagcagaga cggaacagca agtgcaaatg    24780

tcaggaggaa tagaaggagg ctggtgggtg gggtccagtg agcaagagga gggcaggcag    24840

gagaggggat ggggaggtgg gcaggcccag accacccagg gccctggaga ctatcctgat    24900

ccaacaaggg aagccttgag tcacttcagt gtccatgtgg agaatggacc tcagactgaa    24960

tgagggaggc agtaaggagg gcctctacct ccagggcttc gccctgtgga ctgcgcatag    25020

acatctccaa ctcagaaagt ctgaaccaaa ctttccatag ttcccccaag tctgggcatc    25080

ctcctactca gtgaaaggca gccatcacac ctccctgccc tgctcccgga tgccccaaat    25140

cctcttggtc tccaagtcca gaacctgaga cttgtccttg atgtttgtct ttccctcacc    25200

ctttctgtat tctgggaaga tgggtttttt tcccccagat gaatctgtaa aacttctgtg    25260

atcacaataa aaattctggc agtattattt tctggaacat gacaaagtga ttcaaaatta    25320

tttatctgga agactacaaa acaagaatag ccaggaaatt tctaaaaaga aagaagaagg    25380

aggaggagaa agaaggagga ggaaaaggag gagaagaaga aaagaaaaag aaccaagaaa    25440

gggttctagc tctaccaaat attaaaacat atcatgaagc tatttaaaac aatatggttg    25500

tggatactga aaaagatgtg aataaagtgg aaggaaaata aatagaaatg cacatgggga    25560

ttgagactgt gaaaaaggca gcatctcaca tcagtgaggg atgttcaaca cctggtgttg    25620

ggaaaactgg ctagtcattt aaaccaaaca actgggtcct ctacctcact cctgacatta    25680

agatacattt agatgattca aagagtaaga cagaaaaaat aacacgtgaa aacactatca    25740

gaaaacaacg tgggccaggt gtggtgggtc acgcctgtaa tcccagcact ttgggaggcc    25800

gaggcagaca gatcacctga ggtggggagt tcaagaccag cctgaccaac atggtgaaat    25860

cctgtctcta ctaaaaatac aaaattagct gagcgtggtg gcgcatgcct gtaatcccag    25920

ctactcagga ggccgaggca ggagaatcac ttgaacctgg gaggcagagg ttgtggtgag    25980

ccgagatcac gccattgcac tccagcctgg gcaacaagag tgaaaatcca tctaaaaaaa    26040

aaaaaaaaag ccaaggtgga tatttttata gtatcagggt agatcaagct tctccaatca    26100

tgacatgaaa cccagaaacc ataaaagaaa agaatgataa aattgcccac gtaaagtaaa    26160

aagcttgcac acagaaaaac accatacagg ttacaagatg agcagcaaaa tcagagaaaa    26220

aacattgcaa ttcaggacac acagaggcta ttgttcctaa tatttaaaaa taaaagtagt    26280

ggattgtcta caaaaagatg aagacaagaa tttcagaaaa ccaaatactg catgttttca    26340

cttacaagtg gaagctaaac actgagtaca cgtgtacaca aagaatggaa ccataggcca    26400

ggcaccgtgg ctcacgcctg taatcccagt actttgcgag gccgaagcgg gcggatcacc    26460

tgaggtgagg agttcgagac catcctggcc aacatggtga aacccagtct ctactaaaaa    26520

tacaaaaatt agccgggcgt ggtggtgggt gcctgtaatc ccagctactc gggaggctgc    26580

ggcagtagaa tcgcttgaac cctggaggtg gaccttgcag tgagccgaga tcgcaccact    26640

gcactccagc ctgggcaaca gagtgagact ccatctcaaa aaaaaaaaaa aggaatagaa    26700

caatagacac tggggcctac ttgagggagg agggtgagga tcaaaaacct gcctatcagg    26760

tactatgctt attacctggg tggtgaaata atctgtacac caaaccccag tgacatgcaa    26820

tttaccgatg taacaaacct gcccatgtac ccgctgaacc taaaataaaa gttggaaaaa    26880

aatatagaaa ttttctttgt aatagccaaa aactgcaaac agcccaggtg tctattagta    26940

gaatgcataa acaaactcgg gcatgttcat acaatgtaaa actactcatc aataaaaagt    27000

gatacttctc agcaatgaaa agaaactagc tactgatacc agctacaaca tggatggatt    27060

tcaagtgctt tatgatgaga gcaagaagcc agacacaaaa gtgtctatat atatatacag    27120

tatatatacg tatatataca catatataca gtatatatat acatatacat gtatatatat    27180

actgtatata tactgtatat atatacacag tatatatata catatataca gtgtatatat    27240

actgtgtata tatacatgta tatatactga gtatatatac atgtatatat actgtgtata    27300

tatacatgta tatatactga gtatatatac atgtatatat atgtatactg tatatatact    27360

gtatatatat atacacatat atacagtata tatatacagt atatactgta tatatacagt    27420

atatacgtgt atatatacat atatacagta tatatgtaaa tatacatata tacagtatat    27480

atgtaaatat acatatatac atgtatatat atacactata tatatacata tatagtgtat    27540

atatacatat atacatgtat atatttacta tatgattcca tttatataaa gtgccaaaac    27600

agtcaaaaat aatctatgtg gaaaaaatca acaaagggat cccccgggct gcaggaattc    27660

gatggcgcgc cgacgcgcat gctcctctag actcgaggaa ttcggtaccc cgggttcgaa    27720

atcgataagc ttggatccgg agagctcgtt aacatttaaa tggatctacc acatttgtag    27780

aggttttact tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga    27840

atgcaattgt tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata    27900

gcatcacaaa tttcacaaat aaagcaatag catcacaaat ttcacaaata aagcattttt    27960

ttcactgcat tctagttgtg gtttgtccaa actcatcaat gtatcttatc atgtcgagat    28020

ccgcgcggcc gctcactcgt cctcttgaaa atagaacttg gtgaccatca cgccctcgtc    28080

aggcatgttg gtcagggaca cgggctggtc ggcttccatg gcagtgcaca ggaaccagcc    28140

agggcaagcg gcagactcaa agctggtggt ggggccgctg tcgcttctga tgaaggcgaa    28200

tctcttgtcc tgcttccggt tctcgctcag gtcggtgatg ttcacggctt ccagctgcag    28260

ccgtgtctcg tcgccggact tcacgcagct caggcacatc ttgccgccgt ggattcccag    28320

aaacagggcg tggggctcga tgggcaccac gtcgatcttc tcttccaggt tcacattggg    28380

gccctgcagg tagccggcca ccagctgatt gttccgcagg tagaaggttt tctggttcac    28440

gtcccagatc cggaaggcct gcatcttgct ggactttctg ccgctgggcc ggcagattgt    28500

ctcgctgtgg aacaggaaca gcagcagggt aatcaggtgg ctccgcaggc ctctgcagat    28560

ttccataccg gtggatcatg gctctgtctc aggtcagtat aggagctttg atgtgaagtc    28620

agccaagaac agctgaacac tacttctgct gaggcccttt tataggaggg attgcttcct    28680

gtgaataata ggaggatatt gtccacatcc agtaaagagg aaatccccaa ctgcatccaa    28740

aaagttttct gggaatatcc actgctgcag gagtggaaag tccccagtgg aaagtcccca    28800

gtggaaagtc cccagtggaa agtccccagt ggaaagtccc cagaatttcg acggcgcgcc    28860

taccagtaaa aaagaaaacc tattaaaaaa acaccactcg acacggcacc agctcaatca    28920

gtcacagtgt aaaaaagggc caagtgcaga gcgagtatat ataggactaa aaaatgacgt    28980

aacggttaaa gtccacaaaa aacacccaga aaaccgcacg cgaacctacg cccagaaacg    29040

aaagccaaaa aacccacaac ttcctcaaat cgtcacttcc gttttcccac gttacgtcac    29100

ttcccatttt aagaaaacta caattcccaa cacatacaag ttactccgcc ctaaaaccta    29160

cgtcacccgc cccgttccca cgccccgcgc cacgtcacaa actccacccc ctcattatca    29220

tattggcttc aatccaaaat aaggtatatt attgatgatg                          29260
