               SEQUENCE LISTING

<110> Qiagen Beverly, LLC

<120> IMPROVED THERMOSTABLE VIRAL REVERSE TRANSCRIPTASE

<130> Q1-2PCT

<150> US62902183
<151> 2019-09-18

<150> EP19201780.4
<151> 2019-10-07

<160> 19

<210> 1
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 1
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactgatgg gcaatattac ctggatgagc agcggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaatcat gaaagccaat    1080

aaaggttgga gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccgatg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa caggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcgcga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 2
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 2
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Met Gly Asn Ile Thr Trp Met Ser Ser Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Asp Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             

<210> 3
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 3
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactgatgg gcaatattac ctggatgagc agcggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaatcat gaaagccaat    1080

aaaggttgga gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa caggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcgcga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 4
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 4
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Met Gly Asn Ile Thr Trp Met Ser Ser Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             

<210> 5
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 5
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactgatgg gcaatattac ctggatgagc agcggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaatcat gaaagccaat    1080

aaaggttgga gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcacaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa caggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcgcga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 6
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 6
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Met Gly Asn Ile Thr Trp Met Ser Ser Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Gln Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             

<210> 7
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 7
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactggtgg gcaaaattaa ttgggctagc cagggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaatcat gaaagccaat    1080

aaaggttgga gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa caggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcgcga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 8
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 8
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             

<210> 9
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 9
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactggtgg gcaaaattaa ttgggctagc cagggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaggcat gaaagccgct    1080

aaaaccaaaa gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa caggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcgcga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 10
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 10
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Gly Met Lys Ala Ala Lys Thr Lys Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             

<210> 11
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 11
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactggtgg gcaaaattaa ttgggctagc cagggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaatcat gaaagccaat    1080

aaaggttgga gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa cgggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcacga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 12
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 12
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Arg Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile His Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 13
<211> 1674
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..1674
<223> /mol_type="unassigned DNA"
      /note="Synthetic gene"
      /organism="Artificial Sequence"

<400> 13
atggcacagc tgagcaaaga aatcaaattt cgcaaaatcg aactgaaaga aggcaccatg      60

ggtccgaaaa ttccgcagtg gcctctgacc aaagaaaaac tggaaggtgc aaaagaaatt     120

gttcagcgtc tgctgagcga aggtaaaatt agcgaagcaa gcgataataa cccgtataac     180

agcccgattt tcgtgatcaa aaaacgtagc ggtaaatggc gtctgctgca ggatctgcgt     240

gaactgaata aaaccgttca ggttggcacc gaaattagcc gtggtctgcc gcatccgggt     300

ggtctgatta aatgtaaaca catgaccgtt ctggatattg gcgacgcata ttttaccatt     360

ccgctggatc cggaatttcg tccgtatacc gcatttacaa ttccgagcat taatcatcaa     420

gaaccggata aacgttatgt gtggaattgc ctgccgcagg gttttgttct gagcccgtat     480

atctatcaga aaacgctgca agaaattctg cagccatttc gtgaacgtta tccggaagtt     540

cagctgtatc agtatatgga tgacctgttt gtgggtagca atggtagcaa aaaacagcac     600

aaagaactga tcattgaact gcgtgcaatt ctgctggaaa aaggttttga aacaccggat     660

gataaactgc aagaagttcc gccttatagc tggctgggtt atcagctgtg tccggaaaat     720

tggaaagttc agaaaatgca gctggatatg gttaaaaatc cgaccctgaa tgatgtgcag     780

aaactggtgg gcaaaattaa ttgggctagc cagggtgttc cgggtctgac cgttaaacat     840

attgcagcaa ccaccaaagg ttgtctggaa ctgaatcaga aagttatctg gaccgaagaa     900

gcacaaaaag aactggaaga aaacaacgag aaaatcaaaa atgcacaggg cctgcagtat     960

tataacccgg aagaagaaat gctttgcgaa gtggaaatca ccaaaaacta tgaagccacc    1020

tatgtgatta aacagagcca gggtattctg tgggcaggca aaaaaggcat gaaagccgct    1080

aaaaccaaaa gcaccgtgaa aaatctgatg ctgctgctgc aacatgtggc aaccgaaagc    1140

attacccgtg ttggtaaatg tccgaccttt aaagttccgt ttaccaaaga acaggtgatg    1200

tgggaaatgc agaaaggttg gtattatagt tggctgccgg aaattgttta tacccatcag    1260

gttgttcatg atgactggcg tatgaaactg gttgaagaac cgaccagcgg tattaccatt    1320

tataccggtg gtggtaaaca gaatggtgaa ggtattgcag cctatgttac cagcaatggt    1380

cgtaccaaac agaaacgtct gggtccggtt acacatcagg tggcagaacg tatggcaatt    1440

cagatggcac tggaagatac ccgtgataaa cgggttaata ttgtgaccga tagctattat    1500

tgttggaaaa acattaccga aggtctgggt ctggaaggtc cgcagagccc gtggtggccg    1560

attattcaga atattcacga aaaagaaatc gtgtactttg catgggttcc aggtcataaa    1620

ggtatttgtg gtaatcagct ggcagatgaa gcagccaaaa tcaaagaaga gatc          1674


<210> 14
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 14
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Gly Met Lys Ala Ala Lys Thr Lys Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Arg Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile His Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 15
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 10
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Gly Met Lys Ala Ala Lys Thr Asn Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 16
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 10
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Asp Met Lys Ala Ala Lys Thr Lys Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 17
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 10
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Asn Met Lys Ala Ala Lys Asn Ile Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Gln Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Lys Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 18
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 12
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Val Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Arg Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile Arg Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Arg Ile Lys Glu Glu Ile 
545                 550                 555             


<210> 19
<211> 558
<212> PRT
<213> Artificial Sequence

<220> 
<223> Expression from a synthetic gene

<400> 12
Met Ala Gln Leu Ser Lys Glu Ile Lys Phe Arg Lys Ile Glu Leu Lys 
1               5                   10                  15      
Glu Gly Thr Met Gly Pro Lys Ile Pro Gln Trp Pro Leu Thr Lys Glu 
            20                  25                  30          
Lys Leu Glu Gly Ala Lys Glu Ile Val Gln Arg Leu Leu Ser Glu Gly 
        35                  40                  45              
Lys Ile Ser Glu Ala Ser Asp Asn Asn Pro Tyr Asn Ser Pro Ile Phe 
    50                  55                  60                  
Val Ile Lys Lys Arg Ser Gly Lys Trp Arg Leu Leu Gln Asp Leu Arg 
65                  70                  75                  80  
Glu Leu Asn Lys Thr Val Gln Val Gly Thr Glu Ile Ser Arg Gly Leu 
                85                  90                  95      
Pro His Pro Gly Gly Leu Ile Lys Cys Lys His Met Thr Val Leu Asp 
            100                 105                 110         
Ile Gly Asp Ala Tyr Phe Thr Ile Pro Leu Asp Pro Glu Phe Arg Pro 
        115                 120                 125             
Tyr Thr Ala Phe Thr Ile Pro Ser Ile Asn His Gln Glu Pro Asp Lys 
    130                 135                 140                 
Arg Tyr Val Trp Asn Cys Leu Pro Gln Gly Phe Val Leu Ser Pro Tyr 
145                 150                 155                 160 
Ile Tyr Gln Lys Thr Leu Gln Glu Ile Leu Gln Pro Phe Arg Glu Arg 
                165                 170                 175     
Tyr Pro Glu Val Gln Leu Tyr Gln Tyr Met Asp Asp Leu Phe Val Gly 
            180                 185                 190         
Ser Asn Gly Ser Lys Lys Gln His Lys Glu Leu Ile Ile Glu Leu Arg 
        195                 200                 205             
Ala Ile Leu Leu Glu Lys Gly Phe Glu Thr Pro Asp Asp Lys Leu Gln 
    210                 215                 220                 
Glu Val Pro Pro Tyr Ser Trp Leu Gly Tyr Gln Leu Cys Pro Glu Asn 
225                 230                 235                 240 
Trp Lys Val Gln Lys Met Gln Leu Asp Met Val Lys Asn Pro Thr Leu 
                245                 250                 255     
Asn Asp Val Gln Lys Leu Val Gly Lys Ile Asn Trp Ala Ser Gln Gly 
            260                 265                 270         
Val Pro Gly Leu Thr Val Lys His Ile Ala Ala Thr Thr Lys Gly Cys 
        275                 280                 285             
Leu Glu Leu Asn Gln Lys Val Ile Trp Thr Glu Glu Ala Gln Lys Glu 
    290                 295                 300                 
Leu Glu Glu Asn Asn Glu Lys Ile Lys Asn Ala Gln Gly Leu Gln Tyr 
305                 310                 315                 320 
Tyr Asn Pro Glu Glu Glu Met Leu Cys Glu Val Glu Ile Thr Lys Asn 
                325                 330                 335     
Tyr Glu Ala Thr Tyr Val Ile Lys Gln Ser Gln Gly Ile Leu Trp Ala 
            340                 345                 350         
Gly Lys Lys Ile Met Lys Ala Asn Lys Gly Trp Ser Thr Val Lys Asn 
        355                 360                 365             
Leu Met Leu Leu Leu Gln His Val Ala Thr Glu Ser Ile Thr Arg Val 
    370                 375                 380                 
Gly Lys Cys Pro Thr Phe Lys Val Pro Phe Thr Lys Glu Gln Val Met 
385                 390                 395                 400 
Trp Glu Met Gln Lys Gly Trp Tyr Tyr Ser Trp Leu Pro Glu Ile Val 
                405                 410                 415     
Tyr Thr His Gln Val Val His Asp Asp Trp Arg Met Lys Leu Val Glu 
            420                 425                 430         
Glu Pro Thr Ser Gly Ile Thr Ile Tyr Thr Gly Gly Gly Lys Gln Asn 
        435                 440                 445             
Gly Glu Gly Ile Ala Ala Tyr Val Thr Ser Asn Gly Arg Thr Lys Gln 
    450                 455                 460                 
Lys Arg Leu Gly Pro Phe Thr His Gln Val Ala Glu Arg Met Ala Ile 
465                 470                 475                 480 
Gln Met Ala Leu Glu Asp Thr Arg Asp Lys Arg Val Asn Ile Val Thr 
                485                 490                 495     
Asp Ser Tyr Tyr Cys Trp Lys Asn Ile Thr Glu Gly Leu Gly Leu Glu 
            500                 505                 510         
Gly Pro Gln Ser Pro Trp Trp Pro Ile Ile Gln Asn Ile His Glu Lys 
        515                 520                 525             
Glu Ile Val Tyr Phe Ala Trp Val Pro Gly His Lys Gly Ile Cys Gly 
    530                 535                 540                 
Asn Gln Leu Ala Asp Glu Ala Ala Arg Ile Lys Glu Glu Ile 
545                 550                 555             
