                               SEQUENCE LISTING

<110> THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
 
<120> METHODS FOR PRODUCING D-TRYPTOPHAN AND SUBSTITUTED D-TRYPTOPHANS

<130> 304350389WOU1

<140> PCT/US2020/051418
<141> 2020-09-18

<150> 62/902,527
<151> 2019-09-19

<160> 2     

<170> PatentIn version 3.5

<210> 1
<211> 1704
<212> PRT
<213> Aspergillus nidulans

<400> 1
Met Ala Ser Pro Ile Ile Gln Pro Ala Gly Ala Gly Ile His Asp Ile 
1               5                   10                  15      


Phe Thr Gln Leu Glu Leu Trp Glu Ser Ile Asp Lys Gly Leu Ser Met 
            20                  25                  30          


Ile Thr Ile Leu Arg Asp Asn Asp Val Leu Trp Lys Pro Phe Leu Gln 
        35                  40                  45              


Leu Thr Leu Phe Asn Gln Leu Asn Ile Val Arg Lys Ala Trp Ser Ala 
    50                  55                  60                  


Thr Ile Gln Lys Ala Ser Glu Ser Asp Lys Val Pro Thr Leu Lys Asp 
65                  70                  75                  80  


Val Tyr Thr Ser Glu Ser Ser Phe Ile Ala Gln Ala Leu Leu Asp Thr 
                85                  90                  95      


Lys Asn Leu Gln Ile Thr Pro Pro Ala Thr Pro Arg Thr Ala Leu Ser 
            100                 105                 110         


Gly Ala Leu Leu Ala Lys Thr Ile Val Ile Phe His His Ser Glu Arg 
        115                 120                 125             


Ala Gln Glu Glu Leu Gly Thr Glu Leu Pro Glu Glu Val Arg Ser Leu 
    130                 135                 140                 


Val Asn Gln Asn Ala Ile Cys Leu Lys Val Leu Tyr Asn Ala Asn Gln 
145                 150                 155                 160 


Trp His Ile Asp Leu His Tyr Lys Arg Asp Ser Leu Ser Ser Ala Gln 
                165                 170                 175     


Ala Gly Glu Val Ala Glu Ile Phe Glu Gln Tyr Leu Glu Glu Ala Leu 
            180                 185                 190         


Glu Ala Val Ala Ser Ala Ile Pro Pro Ser Pro Pro Val Glu Asp Asp 
        195                 200                 205             


Asn Ala Gly His Gly Gly Leu Cys Lys Glu Arg Thr Asp Cys Pro Lys 
    210                 215                 220                 


Val Asn Arg Cys Ile His Asp Leu Ile Glu Glu Gln Ala Ile Ala Arg 
225                 230                 235                 240 


Pro Asp Gln Glu Gly Ile Cys Ala Tyr Asp Gly Ser Leu Ser Tyr Ala 
                245                 250                 255     


Gly Leu Ser Lys Leu Ser Ser Val Leu Ala Glu Gln Leu Lys Thr Phe 
            260                 265                 270         


Gly Ala Arg Pro Glu Gln Arg Val Ala Ile Leu Met Asn Lys Ser Phe 
        275                 280                 285             


Trp Tyr Pro Val Val Val Leu Ala Val Leu Lys Ser Gly Ala Ala Phe 
    290                 295                 300                 


Val Pro Leu Asp Pro Ser His Pro Lys Asn Arg Leu Lys Gln Leu Ile 
305                 310                 315                 320 


Ser Glu Ile Glu Pro Cys Ala Leu Ile Thr Thr Ser Val Leu Ser Glu 
                325                 330                 335     


Leu Ala Asp Asp Leu Gly Cys Pro Ser Leu Ala Ile Asp Ser Asp Leu 
            340                 345                 350         


Thr Arg Ser Lys Glu Gly Ser Thr Thr Ala Leu Leu Pro Asn Thr Ser 
        355                 360                 365             


Ala Ser Pro Asn Asn Ala Ala Tyr Ile Ile Phe Thr Ser Gly Ser Thr 
    370                 375                 380                 


Gly Lys Pro Lys Gly Val Val Val Glu His Ser Ala Leu Ser Thr Ser 
385                 390                 395                 400 


Ala Ile Thr Arg Gly Val Val Leu Gly Leu Gly Pro Asp Ser Arg Val 
                405                 410                 415     


Leu Gln Tyr Ala Pro His Thr Phe Asp Val Ser Val Asp Glu Ile Leu 
            420                 425                 430         


Thr Thr Leu Ile His Gly Gly Cys Val Cys Val Pro Ser Glu Asp Asp 
        435                 440                 445             


Arg Phe Ser Ile Ala His Phe Met Glu Ser Ala Arg Val Thr Val Ala 
    450                 455                 460                 


Leu Leu Thr Pro Thr Ser Ala Arg Thr Leu His Pro Asp Glu Val Pro 
465                 470                 475                 480 


Ser Leu Arg Ile Leu Gln Thr Gly Gly Glu Val Leu Thr Glu Asp Val 
                485                 490                 495     


Asn Asp Lys Trp Ser Asn Arg Val Thr Leu Phe Asn Val Tyr Gly Pro 
            500                 505                 510         


Thr Glu Ala Ser Val Ala Cys Val Ile Ser Asn Arg Thr Gly Leu Lys 
        515                 520                 525             


Gly Ala Gly His Val Leu Gly Gln Ala Val Gly Gly Lys Leu Trp Ile 
    530                 535                 540                 


Val Asp Pro Asp Asp Ile Glu Arg His Leu Pro Asp Asn Glu Val Gly 
545                 550                 555                 560 


Glu Leu Val Ile Ser Gly Ala Ile Leu Ala Arg Gly Tyr Phe Arg Asp 
                565                 570                 575     


Pro Ser Arg Thr Glu Ser Ser Phe Val Arg Met Arg Asn Gly Glu Arg 
            580                 585                 590         


Val Tyr Arg Thr Gly Asp Leu Ala Ser Met Asp Ser Ala Gly Thr Ile 
        595                 600                 605             


Ile Tyr His Gly Arg Lys Asp Leu Glu Val Lys Ile Arg Gly Gln Arg 
    610                 615                 620                 


Ile Asn Ile Ala Glu Ile Glu Ile Ala Ile Leu Gln Cys Asp Leu Val 
625                 630                 635                 640 


His Ser Val Val Val Glu Tyr Pro Arg Ser Gly Leu Phe Glu Lys Lys 
                645                 650                 655     


Leu Val Ala Val Leu Arg Phe Glu Asp Ser Ser Ser Asp Ala Glu Asp 
            660                 665                 670         


Gly Leu Phe Gly Gly Ala Lys Gly Leu Thr Glu Asp Ile Tyr Cys Leu 
        675                 680                 685             


Leu Leu Ser His Val Ser Ser Val Leu Thr Pro Ala Met Ile Pro Ser 
    690                 695                 700                 


Lys Trp Leu Ser Leu Pro Cys Val Pro Gln Met Pro Ser Gly Lys Ala 
705                 710                 715                 720 


Asp Arg Lys Gln Val Arg Gly Trp Leu Glu Asp Met Asp Lys Arg Thr 
                725                 730                 735     


Tyr Thr Arg Ile Phe His Pro Asn Gly Thr Asp Asn Leu Ile Ser Asp 
            740                 745                 750         


Pro Ser Asp Ser Met Val Ala Ile Trp Leu Lys Val Leu Lys Leu Glu 
        755                 760                 765             


Pro Gln Ser Leu Arg Leu Asp Gln Ser Phe Ile Arg Asn Gly Gly Asp 
    770                 775                 780                 


Ser Ile Met Ala Met Glu Ala Arg His Gln Ala His Glu Ala Gly Ile 
785                 790                 795                 800 


Asn Ile Asp Val Arg Glu Leu Leu Gly Ser Arg Ala Leu Gln Glu Ile 
                805                 810                 815     


Gly Glu Met Ala Thr Lys Thr Ser Ala Val Glu Glu Val Ser Lys Ile 
            820                 825                 830         


Glu Asp Asp Arg Asp Glu Pro Phe Pro Leu Ser Pro Val Gln Gln Met 
        835                 840                 845             


Tyr Phe Asp Lys Val Ser Asp Pro Ser Leu Gly Leu Gln Gln Arg Val 
    850                 855                 860                 


Cys Val Glu Ile Met Thr Lys Ile Gln Pro Asp Met Leu Arg Glu Ala 
865                 870                 875                 880 


Leu Asn His Val Ile Gln Lys His Arg Met Leu Ala Ala Arg Phe Thr 
                885                 890                 895     


Lys His Met Gly Gln Trp Met Gln Gln Val Pro Phe Gly Lys Asn Leu 
            900                 905                 910         


Lys His Leu Ser Arg Cys His Ile Tyr Ser Gln Ala Val Gly Ser Leu 
        915                 920                 925             


Gly Asp Phe Cys Ser Glu Pro Met Ala Leu Glu Asp Gly Thr Leu Leu 
    930                 935                 940                 


His Ala His Leu Gln Ser Ser Gly Glu Arg Gln Thr Leu Val Leu Cys 
945                 950                 955                 960 


Val His His Leu Val Val Asp Phe Val Ser Trp Arg Val Ile Leu Gln 
                965                 970                 975     


Asp Leu His Asp Ala Leu Ala Ala Ala Gln Asn Gly Leu Pro Ser Gly 
            980                 985                 990         


Ile Ser Arg Ser Thr Leu Thr Phe  Gln Gln Trp Cys Arg  Glu Gln Thr 
        995                 1000                 1005             


Lys Tyr  Ala Ser Thr Leu Ile  Pro Glu Ala Val Leu  Pro Phe Ala 
    1010                 1015                 1020             


Pro Gly  Pro Val Asn Leu Arg  Phe Trp Gln Pro Ser  Asn Val Gln 
    1025                 1030                 1035             


Ala Val  Ser Asn Thr Tyr Ser  Glu Ile Val Gln His  Asp Phe Arg 
    1040                 1045                 1050             


Leu Ser  Ser Thr Gln Thr Thr  Gln Met Leu Glu Lys  Phe Thr Thr 
    1055                 1060                 1065             


Ala Thr  Val His Pro Thr Asp  Leu Met Leu Ala Thr  Phe Ala Leu 
    1070                 1075                 1080             


Ala Phe  Lys Arg Ile Phe Thr  Glu Arg Asp Thr Pro  Thr Ile Phe 
    1085                 1090                 1095             


Ile Glu  Gly His Gly Arg Glu  Pro Trp His Ala Ser  Leu Asp Val 
    1100                 1105                 1110             


Ser Gln  Thr Val Gly Trp Phe  Thr Ala Ala Phe Pro  Ile His Leu 
    1115                 1120                 1125             


Pro Lys  Asp Thr Leu Leu Asn  Thr Thr Thr Ala Ile  Leu Gly Ala 
    1130                 1135                 1140             


Ser Glu  Arg Arg Arg Ser Val  Leu Ala Asn Gly His  Pro Tyr Trp 
    1145                 1150                 1155             


Ala Cys  Arg Tyr Leu Ser Pro  Asn Gly Gln Lys Val  Phe Gly Asp 
    1160                 1165                 1170             


Asp Pro  Arg His Gln Glu Met  Glu Phe Val Phe Asn  Tyr Ala Gly 
    1175                 1180                 1185             


Ser Ile  Val Gln Arg Ala Pro  Gly Gln Thr Leu Phe  Ala Glu Asn 
    1190                 1195                 1200             


Val Arg  Ile Ala Glu Ile Gly  His Pro Asn Cys Glu  Arg Phe Ser 
    1205                 1210                 1215             


Leu Phe  Asp Ile Gly Ala Ala  Ile Glu Met Pro Ser  Ser Glu Leu 
    1220                 1225                 1230             


Val Val  Ser Phe Thr Phe Pro  Lys Gly Ile Ala His  Arg Glu Arg 
    1235                 1240                 1245             


Val Ala  Glu Leu Val Lys Thr  Tyr Gln Glu Leu Leu  Glu Thr Ala 
    1250                 1255                 1260             


Val Glu  Arg Asp Leu Asp Leu  Ser Ala Lys Leu Ser  Ser Pro Leu 
    1265                 1270                 1275             


Val Cys  Pro Ala Asp Val Val  Arg Ser Leu Glu Val  Asn Gly Val 
    1280                 1285                 1290             


Cys Ile  Glu Arg Asp Val Glu  Ile Val Tyr Thr Pro  Ser Ser Ile 
    1295                 1300                 1305             


Gln Gln  His Met Leu Trp Arg  Gln Ser Gln Glu Pro  Trp Phe Tyr 
    1310                 1315                 1320             


Arg Val  Gln Gly Asp Trp Thr  Ile Glu Lys Thr Thr  Thr Gln Ser 
    1325                 1330                 1335             


Glu Pro  Val Asp Ile Asp Arg  Leu Ser His Ala Trp  Asn Gln Val 
    1340                 1345                 1350             


Val His  Arg His Thr Thr Leu  Arg Thr Val Phe Arg  Tyr Ser Ser 
    1355                 1360                 1365             


Glu Glu  Glu Arg Phe Val Ala  Ile Val Leu His Glu  Val Lys Pro 
    1370                 1375                 1380             


Ala Ile  Ser Ile Ile Arg Lys  Gly Ile Gln Thr Ser  Gly Ser Leu 
    1385                 1390                 1395             


Cys Arg  Asp Asp Asp Leu Ser  Pro Pro His Arg Met  Val Leu Arg 
    1400                 1405                 1410             


Glu Lys  Asp Asn Gly Ser Val  Val Cys Glu Leu Glu  Phe Ser His 
    1415                 1420                 1425             


Thr Ile  Ile Asp Ala Ala Ser  Arg Ser Ile Val Val  Gln Asp Leu 
    1430                 1435                 1440             


Leu Asp  Ala Tyr Asp Gly Lys  Leu Ala His Arg Pro  Leu Asp Phe 
    1445                 1450                 1455             


Pro Pro  Phe Trp Glu Tyr Ile  Arg Leu Ala Gln Ser  Ser Thr Pro 
    1460                 1465                 1470             


Ser Ala  Arg Lys Glu Glu Leu  His Arg Ala Gly Arg  Val Val Thr 
    1475                 1480                 1485             


Leu Pro  Phe Gln Pro Thr His  Val Leu Ser Lys Val  Pro Glu Ala 
    1490                 1495                 1500             


Cys Lys  Lys Asn Glu Ile Thr  Ile Ser Ser Phe Phe  Met Thr Ala 
    1505                 1510                 1515             


Trp Ser  Ile Val Leu Ala Lys  His Phe Val Ala His  Asn Gln Arg 
    1520                 1525                 1530             


Val Asp  Ser Thr Ser Ser Gln  Ala Val Ala Phe Asp  Tyr Val Leu 
    1535                 1540                 1545             


Ser Asp  Arg Ser Ala Asn Ile  Pro Gly Ile Glu Ser  Ala Val Gly 
    1550                 1555                 1560             


Pro Tyr  Ile Arg Leu Pro Thr  Leu Glu Thr His Val  Lys Glu Gly 
    1565                 1570                 1575             


Val Ser  Leu Lys Asn Ile Ala  Arg Gly Leu His Ala  Gln Cys Thr 
    1580                 1585                 1590             


Phe Gln  Ser Leu Ser Gln Ser  Thr Gln Asp Gly Ser  Ser Leu Glu 
    1595                 1600                 1605             


Leu Pro  Ser Lys Ala Thr Ala  Leu Gln Lys Tyr Ser  Thr Leu Val 
    1610                 1615                 1620             


Asn Ile  Arg Asn Ser Gly Ser  Asp Ser Leu Asp Leu  Val Ser Asp 
    1625                 1630                 1635             


Ser Gly  Glu Trp Lys Trp Ile  Leu Gln Gly Phe Ser  Asp Pro Trp 
    1640                 1645                 1650             


Asp Tyr  Asp Leu Val Phe Ala  Val Asn Val His Ala  Gly Lys Val 
    1655                 1660                 1665             


Thr Gly  Trp Thr Val Glu Tyr  Ala Asp Gly Val Val  Glu His Ser 
    1670                 1675                 1680             


Ala Ala  Asp Glu Ile Ala Lys  Asp Leu Asn Asp Val  Val Glu Arg 
    1685                 1690                 1695             


Met Val  Cys Glu Ile Ile 
    1700                 


<210> 2
<211> 1715
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 2
Met Ala Ser His His His His His His His His Thr Ala Ser Pro Ile 
1               5                   10                  15      


Ile Gln Pro Ala Gly Ala Gly Ile His Asp Ile Phe Thr Gln Leu Glu 
            20                  25                  30          


Leu Trp Glu Ser Ile Asp Lys Gly Leu Ser Met Ile Thr Ile Leu Arg 
        35                  40                  45              


Asp Asn Asp Val Leu Trp Lys Pro Phe Leu Gln Leu Thr Leu Phe Asn 
    50                  55                  60                  


Gln Leu Asn Ile Val Arg Lys Ala Trp Ser Ala Thr Ile Gln Lys Ala 
65                  70                  75                  80  


Ser Glu Ser Asp Lys Val Pro Thr Leu Lys Asp Val Tyr Thr Ser Glu 
                85                  90                  95      


Ser Ser Phe Ile Ala Gln Ala Leu Leu Asp Thr Lys Asn Leu Gln Ile 
            100                 105                 110         


Thr Pro Pro Ala Thr Pro Arg Thr Ala Leu Ser Gly Ala Leu Leu Ala 
        115                 120                 125             


Lys Thr Ile Val Ile Phe His His Ser Glu Arg Ala Gln Glu Glu Leu 
    130                 135                 140                 


Gly Thr Glu Leu Pro Glu Glu Val Arg Ser Leu Val Asn Gln Asn Ala 
145                 150                 155                 160 


Ile Cys Leu Lys Val Leu Tyr Asn Ala Asn Gln Trp His Ile Asp Leu 
                165                 170                 175     


His Tyr Lys Arg Asp Ser Leu Ser Ser Ala Gln Ala Gly Glu Val Ala 
            180                 185                 190         


Glu Ile Phe Glu Gln Tyr Leu Glu Glu Ala Leu Glu Ala Val Ala Ser 
        195                 200                 205             


Ala Ile Pro Pro Ser Pro Pro Val Glu Asp Asp Asn Ala Gly His Gly 
    210                 215                 220                 


Gly Leu Cys Lys Glu Arg Thr Asp Cys Pro Lys Val Asn Arg Cys Ile 
225                 230                 235                 240 


His Asp Leu Ile Glu Glu Gln Ala Ile Ala Arg Pro Asp Gln Glu Gly 
                245                 250                 255     


Ile Cys Ala Tyr Asp Gly Ser Leu Ser Tyr Ala Gly Leu Ser Lys Leu 
            260                 265                 270         


Ser Ser Val Leu Ala Glu Gln Leu Lys Thr Phe Gly Ala Arg Pro Glu 
        275                 280                 285             


Gln Arg Val Ala Ile Leu Met Asn Lys Ser Phe Trp Tyr Pro Val Val 
    290                 295                 300                 


Val Leu Ala Val Leu Lys Ser Gly Ala Ala Phe Val Pro Leu Asp Pro 
305                 310                 315                 320 


Ser His Pro Lys Asn Arg Leu Lys Gln Leu Ile Ser Glu Ile Glu Pro 
                325                 330                 335     


Cys Ala Leu Ile Thr Thr Ser Val Leu Ser Glu Leu Ala Asp Asp Leu 
            340                 345                 350         


Gly Cys Pro Ser Leu Ala Ile Asp Ser Asp Leu Thr Arg Ser Lys Glu 
        355                 360                 365             


Gly Ser Thr Thr Ala Leu Leu Pro Asn Thr Ser Ala Ser Pro Asn Asn 
    370                 375                 380                 


Ala Ala Tyr Ile Ile Phe Thr Ser Gly Ser Thr Gly Lys Pro Lys Gly 
385                 390                 395                 400 


Val Val Val Glu His Ser Ala Leu Ser Thr Ser Ala Ile Thr Arg Gly 
                405                 410                 415     


Val Val Leu Gly Leu Gly Pro Asp Ser Arg Val Leu Gln Tyr Ala Pro 
            420                 425                 430         


His Thr Phe Asp Val Ser Val Asp Glu Ile Leu Thr Thr Leu Ile His 
        435                 440                 445             


Gly Gly Cys Val Cys Val Pro Ser Glu Asp Asp Arg Phe Ser Ile Ala 
    450                 455                 460                 


His Phe Met Glu Ser Ala Arg Val Thr Val Ala Leu Leu Thr Pro Thr 
465                 470                 475                 480 


Ser Ala Arg Thr Leu His Pro Asp Glu Val Pro Ser Leu Arg Ile Leu 
                485                 490                 495     


Gln Thr Gly Gly Glu Val Leu Thr Glu Asp Val Asn Asp Lys Trp Ser 
            500                 505                 510         


Asn Arg Val Thr Leu Phe Asn Val Tyr Gly Pro Thr Glu Ala Ser Val 
        515                 520                 525             


Ala Cys Val Ile Ser Asn Arg Thr Gly Leu Lys Gly Ala Gly His Val 
    530                 535                 540                 


Leu Gly Gln Ala Val Gly Gly Lys Leu Trp Ile Val Asp Pro Asp Asp 
545                 550                 555                 560 


Ile Glu Arg His Leu Pro Asp Asn Glu Val Gly Glu Leu Val Ile Ser 
                565                 570                 575     


Gly Ala Ile Leu Ala Arg Gly Tyr Phe Arg Asp Pro Ser Arg Thr Glu 
            580                 585                 590         


Ser Ser Phe Val Arg Met Arg Asn Gly Glu Arg Val Tyr Arg Thr Gly 
        595                 600                 605             


Asp Leu Ala Ser Met Asp Ser Ala Gly Thr Ile Ile Tyr His Gly Arg 
    610                 615                 620                 


Lys Asp Leu Glu Val Lys Ile Arg Gly Gln Arg Ile Asn Ile Ala Glu 
625                 630                 635                 640 


Ile Glu Ile Ala Ile Leu Gln Cys Asp Leu Val His Ser Val Val Val 
                645                 650                 655     


Glu Tyr Pro Arg Ser Gly Leu Phe Glu Lys Lys Leu Val Ala Val Leu 
            660                 665                 670         


Arg Phe Glu Asp Ser Ser Ser Asp Ala Glu Asp Gly Leu Phe Gly Gly 
        675                 680                 685             


Ala Lys Gly Leu Thr Glu Asp Ile Tyr Cys Leu Leu Leu Ser His Val 
    690                 695                 700                 


Ser Ser Val Leu Thr Pro Ala Met Ile Pro Ser Lys Trp Leu Ser Leu 
705                 710                 715                 720 


Pro Cys Val Pro Gln Met Pro Ser Gly Lys Ala Asp Arg Lys Gln Val 
                725                 730                 735     


Arg Gly Trp Leu Glu Asp Met Asp Lys Arg Thr Tyr Thr Arg Ile Phe 
            740                 745                 750         


His Pro Asn Gly Thr Asp Asn Leu Ile Ser Asp Pro Ser Asp Ser Met 
        755                 760                 765             


Val Ala Ile Trp Leu Lys Val Leu Lys Leu Glu Pro Gln Ser Leu Arg 
    770                 775                 780                 


Leu Asp Gln Ser Phe Ile Arg Asn Gly Gly Asp Ser Ile Met Ala Met 
785                 790                 795                 800 


Glu Ala Arg His Gln Ala His Glu Ala Gly Ile Asn Ile Asp Val Arg 
                805                 810                 815     


Glu Leu Leu Gly Ser Arg Ala Leu Gln Glu Ile Gly Glu Met Ala Thr 
            820                 825                 830         


Lys Thr Ser Ala Val Glu Glu Val Ser Lys Ile Glu Asp Asp Arg Asp 
        835                 840                 845             


Glu Pro Phe Pro Leu Ser Pro Val Gln Gln Met Tyr Phe Asp Lys Val 
    850                 855                 860                 


Ser Asp Pro Ser Leu Gly Leu Gln Gln Arg Val Cys Val Glu Ile Met 
865                 870                 875                 880 


Thr Lys Ile Gln Pro Asp Met Leu Arg Glu Ala Leu Asn His Val Ile 
                885                 890                 895     


Gln Lys His Arg Met Leu Ala Ala Arg Phe Thr Lys His Met Gly Gln 
            900                 905                 910         


Trp Met Gln Gln Val Pro Phe Gly Lys Asn Leu Lys His Leu Ser Arg 
        915                 920                 925             


Cys His Ile Tyr Ser Gln Ala Val Gly Ser Leu Gly Asp Phe Cys Ser 
    930                 935                 940                 


Glu Pro Met Ala Leu Glu Asp Gly Thr Leu Leu His Ala His Leu Gln 
945                 950                 955                 960 


Ser Ser Gly Glu Arg Gln Thr Leu Val Leu Cys Val His His Leu Val 
                965                 970                 975     


Val Asp Phe Val Ser Trp Arg Val Ile Leu Gln Asp Leu His Asp Ala 
            980                 985                 990         


Leu Ala Ala Ala Gln Asn Gly Leu  Pro Ser Gly Ile Ser  Arg Ser Thr 
        995                 1000                 1005             


Leu Thr  Phe Gln Gln Trp Cys  Arg Glu Gln Thr Lys  Tyr Ala Ser 
    1010                 1015                 1020             


Thr Leu  Ile Pro Glu Ala Val  Leu Pro Phe Ala Pro  Gly Pro Val 
    1025                 1030                 1035             


Asn Leu  Arg Phe Trp Gln Pro  Ser Asn Val Gln Ala  Val Ser Asn 
    1040                 1045                 1050             


Thr Tyr  Ser Glu Ile Val Gln  His Asp Phe Arg Leu  Ser Ser Thr 
    1055                 1060                 1065             


Gln Thr  Thr Gln Met Leu Glu  Lys Phe Thr Thr Ala  Thr Val His 
    1070                 1075                 1080             


Pro Thr  Asp Leu Met Leu Ala  Thr Phe Ala Leu Ala  Phe Lys Arg 
    1085                 1090                 1095             


Ile Phe  Thr Glu Arg Asp Thr  Pro Thr Ile Phe Ile  Glu Gly His 
    1100                 1105                 1110             


Gly Arg  Glu Pro Trp His Ala  Ser Leu Asp Val Ser  Gln Thr Val 
    1115                 1120                 1125             


Gly Trp  Phe Thr Ala Ala Phe  Pro Ile His Leu Pro  Lys Asp Thr 
    1130                 1135                 1140             


Leu Leu  Asn Thr Thr Thr Ala  Ile Leu Gly Ala Ser  Glu Arg Arg 
    1145                 1150                 1155             


Arg Ser  Val Leu Ala Asn Gly  His Pro Tyr Trp Ala  Cys Arg Tyr 
    1160                 1165                 1170             


Leu Ser  Pro Asn Gly Gln Lys  Val Phe Gly Asp Asp  Pro Arg His 
    1175                 1180                 1185             


Gln Glu  Met Glu Phe Val Phe  Asn Tyr Ala Gly Ser  Ile Val Gln 
    1190                 1195                 1200             


Arg Ala  Pro Gly Gln Thr Leu  Phe Ala Glu Asn Val  Arg Ile Ala 
    1205                 1210                 1215             


Glu Ile  Gly His Pro Asn Cys  Glu Arg Phe Ser Leu  Phe Asp Ile 
    1220                 1225                 1230             


Gly Ala  Ala Ile Glu Met Pro  Ser Ser Glu Leu Val  Val Ser Phe 
    1235                 1240                 1245             


Thr Phe  Pro Lys Gly Ile Ala  His Arg Glu Arg Val  Ala Glu Leu 
    1250                 1255                 1260             


Val Lys  Thr Tyr Gln Glu Leu  Leu Glu Thr Ala Val  Glu Arg Asp 
    1265                 1270                 1275             


Leu Asp  Leu Ser Ala Lys Leu  Ser Ser Pro Leu Val  Cys Pro Ala 
    1280                 1285                 1290             


Asp Val  Val Arg Ser Leu Glu  Val Asn Gly Val Cys  Ile Glu Arg 
    1295                 1300                 1305             


Asp Val  Glu Ile Val Tyr Thr  Pro Ser Ser Ile Gln  Gln His Met 
    1310                 1315                 1320             


Leu Trp  Arg Gln Ser Gln Glu  Pro Trp Phe Tyr Arg  Val Gln Gly 
    1325                 1330                 1335             


Asp Trp  Thr Ile Glu Lys Thr  Thr Thr Gln Ser Glu  Pro Val Asp 
    1340                 1345                 1350             


Ile Asp  Arg Leu Ser His Ala  Trp Asn Gln Val Val  His Arg His 
    1355                 1360                 1365             


Thr Thr  Leu Arg Thr Val Phe  Arg Tyr Ser Ser Glu  Glu Glu Arg 
    1370                 1375                 1380             


Phe Val  Ala Ile Val Leu His  Glu Val Lys Pro Ala  Ile Ser Ile 
    1385                 1390                 1395             


Ile Arg  Lys Gly Ile Gln Thr  Ser Gly Ser Leu Cys  Arg Asp Asp 
    1400                 1405                 1410             


Asp Leu  Ser Pro Pro His Arg  Met Val Leu Arg Glu  Lys Asp Asn 
    1415                 1420                 1425             


Gly Ser  Val Val Cys Glu Leu  Glu Phe Ser His Thr  Ile Ile Asp 
    1430                 1435                 1440             


Ala Ala  Ser Arg Ser Ile Val  Val Gln Asp Leu Leu  Asp Ala Tyr 
    1445                 1450                 1455             


Asp Gly  Lys Leu Ala His Arg  Pro Leu Asp Phe Pro  Pro Phe Trp 
    1460                 1465                 1470             


Glu Tyr  Ile Arg Leu Ala Gln  Ser Ser Thr Pro Ser  Ala Arg Lys 
    1475                 1480                 1485             


Glu Glu  Leu His Arg Ala Gly  Arg Val Val Thr Leu  Pro Phe Gln 
    1490                 1495                 1500             


Pro Thr  His Val Leu Ser Lys  Val Pro Glu Ala Cys  Lys Lys Asn 
    1505                 1510                 1515             


Glu Ile  Thr Ile Ser Ser Phe  Phe Met Thr Ala Trp  Ser Ile Val 
    1520                 1525                 1530             


Leu Ala  Lys His Phe Val Ala  His Asn Gln Arg Val  Asp Ser Thr 
    1535                 1540                 1545             


Ser Ser  Gln Ala Val Ala Phe  Asp Tyr Val Leu Ser  Asp Arg Ser 
    1550                 1555                 1560             


Ala Asn  Ile Pro Gly Ile Glu  Ser Ala Val Gly Pro  Tyr Ile Arg 
    1565                 1570                 1575             


Leu Pro  Thr Leu Glu Thr His  Val Lys Glu Gly Val  Ser Leu Lys 
    1580                 1585                 1590             


Asn Ile  Ala Arg Gly Leu His  Ala Gln Cys Thr Phe  Gln Ser Leu 
    1595                 1600                 1605             


Ser Gln  Ser Thr Gln Asp Gly  Ser Ser Leu Glu Leu  Pro Ser Lys 
    1610                 1615                 1620             


Ala Thr  Ala Leu Gln Lys Tyr  Ser Thr Leu Val Asn  Ile Arg Asn 
    1625                 1630                 1635             


Ser Gly  Ser Asp Ser Leu Asp  Leu Val Ser Asp Ser  Gly Glu Trp 
    1640                 1645                 1650             


Lys Trp  Ile Leu Gln Gly Phe  Ser Asp Pro Trp Asp  Tyr Asp Leu 
    1655                 1660                 1665             


Val Phe  Ala Val Asn Val His  Ala Gly Lys Val Thr  Gly Trp Thr 
    1670                 1675                 1680             


Val Glu  Tyr Ala Asp Gly Val  Val Glu His Ser Ala  Ala Asp Glu 
    1685                 1690                 1695             


Ile Ala  Lys Asp Leu Asn Asp  Val Val Glu Arg Met  Val Cys Glu 
    1700                 1705                 1710             


Ile Ile  
    1715 


