                         SEQUENCE LISTING

<110>  Academia Sinica
       Shih, Ming-Che
 
<120>  CHIMERIC HEMAGGLUTININ PROTEIN AND A VACCINE COMPOSITION 
       COMPRISING THE SAME

<130>  80073

<150>  US 62/903,011
<151>  2019-09-20

<150>  US 62/904,014
<151>  2019-09-23

<160>  16    

<170>  PatentIn version 3.5

<210>  1
<211>  321
<212>  PRT
<213>  Influenza A virus

<400>  1

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser 
    290                 295                 300                 


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg 
    


<210>  2
<211>  329
<212>  PRT
<213>  Influenza A virus

<400>  2

Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp 
            20                  25                  30          


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
        35                  40                  45              


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe Gln 
65                  70                  75                  80  


Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr Glu Gly Phe Thr Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Gly 
    130                 135                 140                 


Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 
145                 150                 155                 160 


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 
            180                 185                 190         


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Arg Arg 
        195                 200                 205             


Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
    210                 215                 220                 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Val Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg 
                325                 


<210>  3
<211>  319
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rA-HA1

<400>  3

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Trp Thr Gly Val Thr Gln Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Asn Trp Leu Thr 
    130                 135                 140                 


Lys Ser Gly Ser Thr Tyr Pro Val Leu Asn Val Ser Tyr Lys Asn Thr 
145                 150                 155                 160 


Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser Val Ser 
                165                 170                 175     


Thr Ala Glu Gln Thr Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr 
            180                 185                 190         


Val Gly Ser Ser Asn Tyr Gln Gln Thr Ile Ile Pro Ser Pro Gly Ala 
        195                 200                 205             


Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His Trp Leu 
    210                 215                 220                 


Met Leu Asn Pro Asn Asp Thr Val Thr Ile Asn Ser Asn Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met Gly Ile 
                245                 250                 255     


Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys Tyr His 
            260                 265                 270         


Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile Asp Ser 
        275                 280                 285             


Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser Leu Leu 
    290                 295                 300                 


Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly Arg 
305                 310                 315                 


<210>  4
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rB-HA1

<400>  4

Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu Val 
1               5                   10                  15      


Lys Thr Ile Thr Asp Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu 
            20                  25                  30          


Val Gln Ser Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Pro 
                165                 170                 175     


Ser Thr Asn Gln Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Gln Val Asn Gly Leu Ser Ser Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Pro Asn Asp Lys Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg 
    


<210>  5
<211>  320
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rC-HA1

<400>  5

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Ser Ser Thr Gly Lys Ile Cys Asn Asn Pro His Arg Ile 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Met Arg Ser Asp Ala Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Ile Ser Asn Leu Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Val Lys Gln Arg Ser Leu 
    290                 295                 300                 


Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly Arg 
305                 310                 315                 320 


<210>  6
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rD-HA1

<400>  6

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Gly Ser Asn Ala 
        115                 120                 125             


Cys Lys Arg Gly Pro Gly Ser Asp Phe Tyr Ala Glu Met Lys Trp Leu 
    130                 135                 140                 


Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Thr Met 
145                 150                 155                 160 


Pro Asn Asn Asp Asn Phe Asp Lys Leu Tyr Val Trp Gly Ile His His 
                165                 170                 175     


Ser Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys 
            180                 185                 190         


Leu Val Thr Val Ser Thr Arg Arg Ser Gln Gln Ser Phe Val Pro Ser 
        195                 200                 205             


Pro Gly Ala Arg Pro Trp Val Arg Gly Leu Ser Gly Arg Ile Asp Phe 
    210                 215                 220                 


His Trp Thr Ile Val Lys Pro Gly Asp Val Leu Val Phe Ser Phe Asn 
225                 230                 235                 240 


Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser 
                245                 250                 255     


Met Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp 
            260                 265                 270         


Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn 
        275                 280                 285             


Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg 
    290                 295                 300                 


Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys 
305                 310                 315                 320 


Gly Arg 
        


<210>  7
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rE-HA1

<400>  7

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Ile Asp Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro 
    50                  55                  60                  


His Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ser Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Phe Ser Arg Leu Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Ile Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser 
    290                 295                 300                 


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg 
    


<210>  8
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  rF-HA1

<400>  8

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Leu Asp Gly Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Val Phe Gln Asn Glu Thr Trp Asp Leu Phe Val Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr 
            100                 105                 110         


Glu Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Arg Gly Tyr Phe Lys Met Arg Thr Gly Lys Ser 
                245                 250                 255     


Ser Ile Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp 
            260                 265                 270         


Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn 
        275                 280                 285             


Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg 
    290                 295                 300                 


Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys 
305                 310                 315                 320 


Gly Arg 
        


<210>  9
<211>  542
<212>  PRT
<213>  Influenza A virus

<400>  9

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser 
    290                 295                 300                 


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                325                 330                 335     


Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly 
            340                 345                 350         


Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln 
        355                 360                 365             


Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe 
    370                 375                 380                 


Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn 
385                 390                 395                 400 


Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn 
                405                 410                 415     


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala 
            420                 425                 430         


Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg 
        435                 440                 445             


Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys 
    450                 455                 460                 


Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His 
465                 470                 475                 480 


Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro 
                485                 490                 495     


Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe 
            500                 505                 510         


Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe 
        515                 520                 525             


Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540         


<210>  10
<211>  550
<212>  PRT
<213>  Influenza A virus

<400>  10

Gln Asp Leu Pro Gly Asn Asp Asn Ser Thr Ala Thr Leu Cys Leu Gly 
1               5                   10                  15      


His His Ala Val Pro Asn Gly Thr Leu Val Lys Thr Ile Thr Asp Asp 
            20                  25                  30          


Gln Ile Glu Val Thr Asn Ala Thr Glu Leu Val Gln Ser Ser Ser Thr 
        35                  40                  45              


Gly Lys Ile Cys Asn Asn Pro His Arg Ile Leu Asp Gly Ile Asp Cys 
    50                  55                  60                  


Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro His Cys Asp Val Phe Gln 
65                  70                  75                  80  


Asn Glu Thr Trp Asp Leu Phe Val Glu Arg Ser Lys Ala Phe Ser Asn 
                85                  90                  95      


Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala Ser Leu Arg Ser Leu Val 
            100                 105                 110         


Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr Glu Gly Phe Thr Trp Thr 
        115                 120                 125             


Gly Val Thr Gln Asn Gly Gly Ser Asn Ala Cys Lys Arg Gly Pro Gly 
    130                 135                 140                 


Ser Gly Phe Phe Ser Arg Leu Asn Trp Leu Thr Lys Ser Gly Ser Thr 
145                 150                 155                 160 


Tyr Pro Val Leu Asn Val Thr Met Pro Asn Asn Asp Asn Phe Asp Lys 
                165                 170                 175     


Leu Tyr Ile Trp Gly Val His His Pro Ser Thr Asn Gln Glu Gln Thr 
            180                 185                 190         


Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr Val Ser Thr Arg Arg 
        195                 200                 205             


Ser Gln Gln Thr Ile Ile Pro Asn Ile Gly Ser Arg Pro Trp Val Arg 
    210                 215                 220                 


Gly Leu Ser Ser Arg Ile Ser Ile Tyr Trp Thr Ile Val Lys Pro Gly 
225                 230                 235                 240 


Asp Val Leu Val Ile Asn Ser Asn Gly Asn Leu Ile Ala Pro Arg Gly 
                245                 250                 255     


Tyr Phe Lys Met Arg Thr Gly Lys Ser Ser Ile Met Arg Ser Asp Ala 
            260                 265                 270         


Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile Thr Pro Asn Gly Ser Ile 
        275                 280                 285             


Pro Asn Asp Lys Pro Phe Gln Asn Val Asn Lys Ile Thr Tyr Gly Ala 
    290                 295                 300                 


Cys Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Gly Met 
305                 310                 315                 320 


Arg Asn Val Pro Glu Lys Gln Thr Arg Gly Leu Phe Gly Ala Ile Ala 
                325                 330                 335     


Gly Phe Ile Glu Asn Gly Trp Glu Gly Met Ile Asp Gly Trp Tyr Gly 
            340                 345                 350         


Phe Arg His Gln Asn Ser Glu Gly Thr Gly Gln Ala Ala Asp Leu Lys 
        355                 360                 365             


Ser Thr Gln Ala Ala Ile Asp Gln Ile Asn Gly Lys Leu Asn Arg Val 
    370                 375                 380                 


Ile Glu Lys Thr Asn Glu Lys Phe His Gln Ile Glu Lys Glu Phe Ser 
385                 390                 395                 400 


Glu Val Glu Gly Arg Ile Gln Asp Leu Glu Lys Tyr Val Glu Asp Thr 
                405                 410                 415     


Lys Ile Asp Leu Trp Ser Tyr Asn Ala Glu Leu Leu Val Ala Leu Glu 
            420                 425                 430         


Asn Gln His Thr Ile Asp Leu Thr Asp Ser Glu Met Asn Lys Leu Phe 
        435                 440                 445             


Glu Lys Thr Arg Arg Gln Leu Arg Glu Asn Ala Glu Asp Met Gly Asn 
    450                 455                 460                 


Gly Cys Phe Lys Ile Tyr His Lys Cys Asp Asn Ala Cys Ile Glu Ser 
465                 470                 475                 480 


Ile Arg Asn Gly Thr Tyr Asp His Asp Val Tyr Arg Asp Glu Ala Leu 
                485                 490                 495     


Asn Asn Arg Phe Gln Ile Lys Gly Val Glu Leu Lys Ser Gly Tyr Lys 
            500                 505                 510         


Asp Trp Ile Leu Trp Ile Ser Phe Ala Ile Ser Cys Phe Leu Leu Cys 
        515                 520                 525             


Val Val Leu Leu Gly Phe Ile Met Trp Ala Cys Gln Arg Gly Asn Ile 
    530                 535                 540                 


Arg Cys Asn Ile Cys Ile 
545                 550 


<210>  11
<211>  540
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrA-HA

<400>  11

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Trp Thr Gly Val Thr Gln Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Asn Trp Leu Thr 
    130                 135                 140                 


Lys Ser Gly Ser Thr Tyr Pro Val Leu Asn Val Ser Tyr Lys Asn Thr 
145                 150                 155                 160 


Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser Val Ser 
                165                 170                 175     


Thr Ala Glu Gln Thr Ser Leu Tyr Val Gln Ala Ser Gly Arg Val Thr 
            180                 185                 190         


Val Gly Ser Ser Asn Tyr Gln Gln Thr Ile Ile Pro Ser Pro Gly Ala 
        195                 200                 205             


Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His Trp Leu 
    210                 215                 220                 


Met Leu Asn Pro Asn Asp Thr Val Thr Ile Asn Ser Asn Gly Asn Leu 
225                 230                 235                 240 


Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met Gly Ile 
                245                 250                 255     


Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys Tyr His 
            260                 265                 270         


Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile Asp Ser 
        275                 280                 285             


Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser Leu Leu 
    290                 295                 300                 


Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly Arg Gly 
305                 310                 315                 320 


Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly Leu 
                325                 330                 335     


Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Glu Gly 
            340                 345                 350         


Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile Thr 
        355                 360                 365             


Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe Glu Leu 
    370                 375                 380                 


Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn Val Ile 
385                 390                 395                 400 


Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn Ala Glu 
                405                 410                 415     


Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp Ser 
            420                 425                 430         


Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu Asn 
        435                 440                 445             


Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys Asp 
    450                 455                 460                 


Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser Lys 
465                 470                 475                 480 


Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro Val Lys 
                485                 490                 495     


Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe Gly Ala 
            500                 505                 510         


Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe Ile Cys 
        515                 520                 525             


Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540 


<210>  12
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrB-HA

<400>  12

Ala Thr Leu Cys Leu Gly His His Ala Val Pro Asn Gly Thr Leu Val 
1               5                   10                  15      


Lys Thr Ile Thr Asp Asp Gln Ile Glu Val Thr Asn Ala Thr Glu Leu 
            20                  25                  30          


Val Gln Ser Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Pro 
                165                 170                 175     


Ser Thr Asn Gln Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Asn Ile 
        195                 200                 205             


Gly Ser Arg Pro Gln Val Asn Gly Leu Ser Ser Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Pro Asn Asp Lys Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Asn Thr 
    290                 295                 300                 


Leu Lys Leu Ala Thr Gly Met Arg Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                325                 330                 335     


Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly 
            340                 345                 350         


Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln 
        355                 360                 365             


Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe 
    370                 375                 380                 


Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn 
385                 390                 395                 400 


Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn 
                405                 410                 415     


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala 
            420                 425                 430         


Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg 
        435                 440                 445             


Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys 
    450                 455                 460                 


Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His 
465                 470                 475                 480 


Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro 
                485                 490                 495     


Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe 
            500                 505                 510         


Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe 
        515                 520                 525             


Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540         


<210>  13
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrC-HA

<400>  13

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Ser Ser Thr Gly Lys Ile Cys Asn Asn Pro His Arg Ile 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Met Arg Ser Asp Ala Pro Ile Asp Thr Cys Ile Ser Glu Cys Ile 
            260                 265                 270         


Thr Pro Asn Gly Ser Ile Ile Ser Asn Leu Pro Phe Gln Asn Val Asn 
        275                 280                 285             


Lys Ile Thr Tyr Gly Ala Cys Pro Lys Tyr Val Lys Gln Arg Ser Leu 
    290                 295                 300                 


Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly Arg 
305                 310                 315                 320 


Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly 
                325                 330                 335     


Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly Glu 
            340                 345                 350         


Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln Ile 
        355                 360                 365             


Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe Glu 
    370                 375                 380                 


Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn Val 
385                 390                 395                 400 


Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn Ala 
                405                 410                 415     


Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala Asp 
            420                 425                 430         


Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg Glu 
        435                 440                 445             


Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys Cys 
    450                 455                 460                 


Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His Ser 
465                 470                 475                 480 


Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro Val 
                485                 490                 495     


Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe Gly 
            500                 505                 510         


Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe Ile 
        515                 520                 525             


Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540     


<210>  14
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrD-HA

<400>  14

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Gly Ser Asn Ala 
        115                 120                 125             


Cys Lys Arg Gly Pro Gly Ser Asp Phe Tyr Ala Glu Met Lys Trp Leu 
    130                 135                 140                 


Leu Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Thr Met 
145                 150                 155                 160 


Pro Asn Asn Asp Asn Phe Asp Lys Leu Tyr Val Trp Gly Ile His His 
                165                 170                 175     


Ser Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys 
            180                 185                 190         


Leu Val Thr Val Ser Thr Arg Arg Ser Gln Gln Ser Phe Val Pro Ser 
        195                 200                 205             


Pro Gly Ala Arg Pro Trp Val Arg Gly Leu Ser Gly Arg Ile Asp Phe 
    210                 215                 220                 


His Trp Thr Ile Val Lys Pro Gly Asp Val Leu Val Phe Ser Phe Asn 
225                 230                 235                 240 


Gly Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser 
                245                 250                 255     


Met Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp 
            260                 265                 270         


Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn 
        275                 280                 285             


Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg 
    290                 295                 300                 


Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys 
305                 310                 315                 320 


Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp 
                325                 330                 335     


Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln 
            340                 345                 350         


Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp 
        355                 360                 365             


Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln 
    370                 375                 380                 


Phe Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly 
385                 390                 395                 400 


Asn Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr 
                405                 410                 415     


Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu 
            420                 425                 430         


Ala Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu 
        435                 440                 445             


Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His 
    450                 455                 460                 


Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp 
465                 470                 475                 480 


His Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp 
                485                 490                 495     


Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser 
            500                 505                 510         


Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val 
        515                 520                 525             


Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540             


<210>  15
<211>  542
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrE-HA

<400>  15

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Val Asp Leu Ile Asp Cys Thr Leu Ile Asp Ala Leu Leu Gly Asp Pro 
    50                  55                  60                  


His Cys Asp Gln Phe Leu Glu Phe Ser Ala Asp Leu Ile Ile Glu Arg 
65                  70                  75                  80  


Ser Lys Ala Phe Ser Asn Cys Tyr Pro Tyr Asp Val Pro Asp Tyr Ala 
                85                  90                  95      


Ser Leu Arg Gln Ile Leu Arg Glu Ser Gly Gly Ile Asp Lys Glu Ala 
            100                 105                 110         


Met Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Phe Ser Arg Leu Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Ile Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Ser Ile Tyr 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Asp Arg Ala Ser Phe Leu Arg Gly Lys Ser Met 
                245                 250                 255     


Gly Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp Cys 
            260                 265                 270         


Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn Ile 
        275                 280                 285             


Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg Ser 
    290                 295                 300                 


Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys Gly 
305                 310                 315                 320 


Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu 
                325                 330                 335     


Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln Gly 
            340                 345                 350         


Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp Gln 
        355                 360                 365             


Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln Phe 
    370                 375                 380                 


Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly Asn 
385                 390                 395                 400 


Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr Asn 
                405                 410                 415     


Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu Ala 
            420                 425                 430         


Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu Arg 
        435                 440                 445             


Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His Lys 
    450                 455                 460                 


Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp His 
465                 470                 475                 480 


Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp Pro 
                485                 490                 495     


Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser Phe 
            500                 505                 510         


Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val Phe 
        515                 520                 525             


Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540         


<210>  16
<211>  543
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FrF-HA

<400>  16

Asp Lys Ile Cys Leu Gly His His Ala Val Ser Asn Gly Thr Lys Val 
1               5                   10                  15      


Asn Thr Leu Thr Glu Arg Gly Val Glu Val Val Asn Ala Thr Glu Thr 
            20                  25                  30          


Val Glu Arg Thr Asn Ile Pro Arg Ile Cys Ser Lys Gly Lys Arg Thr 
        35                  40                  45              


Leu Asp Gly Gly Gln Cys Gly Leu Leu Gly Thr Ile Thr Gly Pro Pro 
    50                  55                  60                  


Gln Cys Asp Val Phe Gln Asn Glu Thr Trp Asp Leu Phe Val Glu Arg 
65                  70                  75                  80  


Arg Glu Gly Ser Asp Val Cys Tyr Pro Gly Lys Phe Val Asn Glu Glu 
                85                  90                  95      


Ala Leu Arg Ser Leu Val Ala Ser Ser Gly Thr Leu Glu Phe Ile Thr 
            100                 105                 110         


Glu Gly Phe Thr Tyr Ser Gly Ile Arg Thr Asn Gly Ala Thr Ser Ala 
        115                 120                 125             


Cys Arg Arg Ser Gly Ser Ser Phe Tyr Ala Glu Met Lys Trp Leu Leu 
    130                 135                 140                 


Ser Asn Thr Asp Asn Ala Ala Phe Pro Gln Met Thr Lys Ser Tyr Lys 
145                 150                 155                 160 


Asn Thr Arg Lys Ser Pro Ala Leu Ile Val Trp Gly Ile His His Ser 
                165                 170                 175     


Val Ser Thr Ala Glu Gln Thr Lys Leu Tyr Gly Ser Gly Asn Lys Leu 
            180                 185                 190         


Val Thr Val Gly Ser Ser Asn Tyr Gln Gln Ser Phe Val Pro Ser Pro 
        195                 200                 205             


Gly Ala Arg Pro Gln Val Asn Gly Leu Ser Gly Arg Ile Asp Phe His 
    210                 215                 220                 


Trp Leu Met Leu Asn Pro Asn Asp Thr Val Thr Phe Ser Phe Asn Gly 
225                 230                 235                 240 


Ala Phe Ile Ala Pro Arg Gly Tyr Phe Lys Met Arg Thr Gly Lys Ser 
                245                 250                 255     


Ser Ile Ile Gln Ser Gly Val Gln Val Asp Ala Asn Cys Glu Gly Asp 
            260                 265                 270         


Cys Tyr His Ser Gly Gly Thr Ile Ile Ser Asn Leu Pro Phe Gln Asn 
        275                 280                 285             


Ile Asp Ser Arg Ala Val Gly Lys Cys Pro Arg Tyr Val Lys Gln Arg 
    290                 295                 300                 


Ser Leu Leu Leu Ala Thr Gly Met Lys Asn Val Pro Glu Ile Pro Lys 
305                 310                 315                 320 


Gly Arg Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp 
                325                 330                 335     


Glu Gly Leu Ile Asp Gly Trp Tyr Gly Phe Arg His Gln Asn Ala Gln 
            340                 345                 350         


Gly Glu Gly Thr Ala Ala Asp Tyr Lys Ser Thr Gln Ser Ala Ile Asp 
        355                 360                 365             


Gln Ile Thr Gly Lys Leu Asn Arg Leu Ile Glu Lys Thr Asn Gln Gln 
    370                 375                 380                 


Phe Glu Leu Ile Asp Asn Glu Phe Asn Glu Val Glu Lys Gln Ile Gly 
385                 390                 395                 400 


Asn Val Ile Asn Trp Thr Arg Asp Ser Ile Thr Glu Val Trp Ser Tyr 
                405                 410                 415     


Asn Ala Glu Leu Leu Val Ala Met Glu Asn Gln His Thr Ile Asp Leu 
            420                 425                 430         


Ala Asp Ser Glu Met Asp Lys Leu Tyr Glu Arg Val Lys Arg Gln Leu 
        435                 440                 445             


Arg Glu Asn Ala Glu Glu Asp Gly Thr Gly Cys Phe Glu Ile Phe His 
    450                 455                 460                 


Lys Cys Asp Asp Asp Cys Met Ala Ser Ile Arg Asn Asn Thr Tyr Asp 
465                 470                 475                 480 


His Ser Lys Tyr Arg Glu Glu Ala Met Gln Asn Arg Ile Gln Ile Asp 
                485                 490                 495     


Pro Val Lys Leu Ser Ser Gly Tyr Lys Asp Val Ile Leu Trp Phe Ser 
            500                 505                 510         


Phe Gly Ala Ser Cys Phe Ile Leu Leu Ala Ile Val Met Gly Leu Val 
        515                 520                 525             


Phe Ile Cys Val Lys Asn Gly Asn Met Arg Cys Thr Ile Cys Ile 
    530                 535                 540             


