                         SEQUENCE LISTING

<110>  Auburn University
       Baker, Henry J.
       Martin, Douglas R.
       Sena-Esteves, Miguel
       Van Kampen, Kent R.
 
<120>  ANTIBODY GENE THERAPY FOR TREATMENT AND PREVENTION OF INFECTION 
       BY RABIES LYSSAVIRUS

<130>  169996.00468

<150>  62/901,426
<151>  2019-09-17

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-rabies antibody gene pAAV-CBA-CR57-nHL-wpre Clone
       2969

<400>  1
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga cgctgccttc gccccgtgcc      840

ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt tactcccaca      900

ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg tttaatgacg      960

gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagc tagagcctct     1020

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt     1080

gtgctgtctc atcattttgg caaagaattc ctcgaagatc cgaaggggtt caagcttaaa     1140

aactagtcag ccaccatggc ctgccccggc ttcctgtggg ccctggtgat cagcacctgc     1200

ctggaattca gcatggccca ggtgcagctg gtgcagagcg gagccgaggt gaagaagccc     1260

ggcagcagcg tgaaggtgag ctgcaaggcc agcggcggca ccttcaacag gtacaccgtg     1320

aactgggtga gacaggcccc aggccagggc ctggagtgga tgggcggcat catccctatc     1380

ttcggcaccg ccaactacgc ccagagattc cagggcaggc tcaccatcac cgccgacgag     1440

agcaccagca ccgcctacat ggagctgagc agcctgagaa gcgatgacac cgccgtgtac     1500


<210>  2
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-rabies antibody gene pAAV-CBA-CR57v1.1-wpre Clone
       2970_2

<400>  2
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga cgctgccttc gccccgtgcc      840

ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt tactcccaca      900

ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg tttaatgacg      960

gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagc tagagcctct     1020

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt     1080

gtgctgtctc atcattttgg caaagaattc ctcgaagatc cgaaggggtt caagcttaaa     1140

aactagtcag ccaccatggc gacgggttca agaacttccc tacttcttgc atttggcctg     1200

ctttgtttgc cgtggttaca ggagggctcg gcacaggtgc agctggtgca gagcggagcc     1260

gaggtgaaga agcccggcag cagcgtgaag gtgagctgca aggccagcgg cggcaccttc     1320

aacaggtaca ccgtgaactg ggtgagacag gccccaggcc agggcctgga gtggatgggc     1380

ggcatcatcc ctatcttcgg caccgccaac tacgcccaga gattccaggg caggctcacc     1440

atcaccgccg acgagagcac cagcaccgcc tacatggagc tgagcagcct gagaagcgat     1500


<210>  3
<211>  1500
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic- anti-rabies antibody gene pAAV-CBA-CR57v3.1-wpre Clone
       2971

<400>  3
ttggccactc cctctctgcg cgctcgctcg ctcactgagg ccgggcgacc aaaggtcgcc       60

cgacgcccgg gctttgcccg ggcggcctca gtgagcgagc gagcgcgcag agagggagtg      120

gccaactcca tcactagggg ttcctagatc tgaattcggt accctagtta ttaatagtaa      180

tcaattacgg ggtcattagt tcatagccca tatatggagt tccgcgttac ataacttacg      240

gtaaatggcc cgcctggctg accgcccaac gacccccgcc cattgacgtc aataatgacg      300

tatgttccca tagtaacgcc aatagggact ttccattgac gtcaatgggt ggactattta      360

cggtaaactg cccacttggc agtacatcaa gtgtatcata tgccaagtac gccccctatt      420

gacgtcaatg acggtaaatg gcccgcctgg cattatgccc agtacatgac cttatgggac      480

tttcctactt ggcagtacat ctacgtatta gtcatcgcta ttaccatggt cgaggtgagc      540

cccacgttct gcttcactct ccccatctcc cccccctccc cacccccaat tttgtattta      600

tttatttttt aattattttg tgcagcgatg ggggcggggg gggggggggg gcgcgcgcca      660

ggcggggcgg ggcggggcga ggggcggggc ggggcgaggc ggagaggtgc ggcggcagcc      720

aatcagagcg gcgcgctccg aaagtttcct tttatggcga ggcggcggcg gcggcggccc      780

tataaaaagc gaagcgcgcg gcgggcggga gtcgctgcga cgctgccttc gccccgtgcc      840

ccgctccgcc gccgcctcgc gccgcccgcc ccggctctga ctgaccgcgt tactcccaca      900

ggtgagcggg cgggacggcc cttctcctcc gggctgtaat tagcgcttgg tttaatgacg      960

gcttgtttct tttctgtggc tgcgtgaaag ccttgagggg ctccgggagc tagagcctct     1020

gctaaccatg ttcatgcctt cttctttttc ctacagctcc tgggcaacgt gctggttatt     1080

gtgctgtctc atcattttgg caaagaattc ctcgaagatc cgaaggggtt caagcttaaa     1140

aactagtcag ccaccatggc gacgggttca agaacttccc tacttcttgc atttggcctg     1200

ctttgtttgc cgtggttaca ggagggctcg gcacaggtgc agctggtgca gagcggagcc     1260

gaggtgaaga agcccggcag cagcgtgaag gtgagctgca aggccagcgg cggcaccttc     1320

aacaggtaca ccgtgaactg ggtgagacag gccccaggcc agggcctgga gtggatgggc     1380

ggcatcatcc ctatcttcgg caccgccaac tacgcccaga gattccaggg caggctcacc     1440

atcaccgccg acgagagcac cagcaccgcc tacatggagc tgagcagcct gagaagcgat     1500


<210>  4
<211>  755
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic- expression cassette for rabies virus antibody gene

<400>  4

Met Ala Thr Gly Ser Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu 
1               5                   10                  15      


Cys Leu Pro Trp Leu Gln Glu Gly Ser Ala Val Lys Leu Gln Gln Ser 
            20                  25                  30          


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala 
        35                  40                  45              


Ala Ser Gly Phe Asp Phe Ser Arg Tyr Trp Met Ser Trp Val Arg Gln 
    50                  55                  60                  


Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly Glu Ile Asn Pro Asp Ser 
65                  70                  75                  80  


Ser Thr Ile Asn Tyr Thr Pro Ser Leu Lys Asp Thr Phe Ile Ile Ser 
                85                  90                  95      


Arg Asp Asn Ala Lys Asn Thr Leu Tyr Leu Gln Met Ser Lys Val Arg 
            100                 105                 110         


Ser Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Arg Gln Gly Tyr Asp Gly 
        115                 120                 125             


Tyr His Trp Tyr Phe Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val 
    130                 135                 140                 


Ser Ser Glu Ser Leu Asp Leu Ala Lys Thr Thr Pro Pro Ser Val Tyr 
145                 150                 155                 160 


Pro Leu Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu 
                165                 170                 175     


Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp 
            180                 185                 190         


Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 
        195                 200                 205             


Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser 
    210                 215                 220                 


Thr Trp Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser 
225                 230                 235                 240 


Ser Thr Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys 
                245                 250                 255     


Pro Cys Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro 
            260                 265                 270         


Pro Lys Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr 
        275                 280                 285             


Cys Val Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser 
    290                 295                 300                 


Trp Phe Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg 
305                 310                 315                 320 


Glu Glu Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile 
                325                 330                 335     


Met His Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn 
            340                 345                 350         


Ser Ala Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
        355                 360                 365             


Gly Arg Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu 
    370                 375                 380                 


Gln Met Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe 
385                 390                 395                 400 


Phe Pro Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala 
                405                 410                 415     


Glu Asn Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr 
            420                 425                 430         


Phe Val Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly 
        435                 440                 445             


Asn Thr Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His 
    450                 455                 460                 


Thr Glu Lys Ser Leu Ser His Ser Pro Gly Lys Arg Lys Arg Arg Ser 
465                 470                 475                 480 


Gly Ser Gly Ala Pro Val Lys Gln Thr Leu Asn Phe Asp Leu Leu Lys 
                485                 490                 495     


Leu Ala Gly Asp Val Glu Ser Asn Pro Gly Pro Met Ala Thr Gly Ser 
            500                 505                 510         


Arg Thr Ser Leu Leu Leu Ala Phe Gly Leu Leu Cys Leu Pro Trp Leu 
        515                 520                 525             


Gln Glu Gly Ser Ala Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu 
    530                 535                 540                 


Ser Ala Ser Val Gly Glu Thr Val Thr Leu Thr Cys Gly Ala Ser Glu 
545                 550                 555                 560 


Asn Ile Tyr Gly Gly Leu Asn Trp Tyr Gln Arg Lys Gln Gly Lys Ser 
                565                 570                 575     


Pro Gln Leu Leu Ile Tyr Gly Ala Thr Lys Leu Ala Asp Gly Met Ser 
            580                 585                 590         


Ser Arg Phe Ser Gly Gly Gly Ser Gly Arg Gln Tyr Phe Leu Lys Ile 
        595                 600                 605             


Thr Ser Leu His Pro Asp Asp Val Ala Thr Tyr Tyr Cys Gln Asn Val 
    610                 615                 620                 


Leu Ser Asn Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
625                 630                 635                 640 


Arg Ala Asp Ala Ala Pro Thr Val Ser Ala Asp Ala Ala Pro Thr Val 
                645                 650                 655     


Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser 
            660                 665                 670         


Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys 
        675                 680                 685             


Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp 
    690                 695                 700                 


Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu 
705                 710                 715                 720 


Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu 
                725                 730                 735     


Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg 
            740                 745                 750         


Asn Glu Cys 
        755 


