                         SEQUENCE LISTING

<110>  Dana-Farber Cancer Institute, Inc.
       Fischer, Eric S
       Roy Burman, Shourya S
       Faust, Tyler
       Yoon, Hojong
       Nowak, Radoslaw P
 
<120>  PROTEIN TAG TO INDUCE LIGAND DEPENDENT DEGRADATION OF 
       PROTEIN/PROTEIN-FUSIONS

<130>  52095-638001WO

<140>  Not Yet Assigned
<141>  2020-09-17

<150>  62/902,275
<151>  2019-09-18

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  530
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15      


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30          


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45              


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60                  


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95      


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110         


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125             


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140                 


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160 


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175     


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190         


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205             


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220                 


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240 


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255     


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270         


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285             


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300                 


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320 


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335     


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350         


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365             


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380                 


Leu Ala Phe Gly Ala Val Ala Glu Phe Ser Phe Val Ile Asp Leu Gln 
385                 390                 395                 400 


Thr Arg Leu Ser Gln Gln Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala 
                405                 410                 415     


Ser Val Gln Pro Leu Ala Thr Gln Cys Phe Gln Leu Ser Asn Met Phe 
            420                 425                 430         


Asn Pro Gln Thr Glu Glu Glu Val Gly Trp Asp Thr Glu Ile Lys Asp 
        435                 440                 445             


Asp Val Ile Glu Glu Cys Asn Lys His Gly Gly Val Ile His Ile Tyr 
    450                 455                 460                 


Val Asp Lys Asn Ser Ala Gln Gly Asn Val Tyr Val Lys Cys Pro Ser 
465                 470                 475                 480 


Ile Ala Ala Ala Ile Ala Ala Val Asn Ala Leu His Gly Arg Trp Phe 
                485                 490                 495     


Ala Gly Lys Met Ile Thr Ala Ala Tyr Val Pro Leu Pro Thr Tyr His 
            500                 505                 510         


Asn Leu Phe Pro Asp Ser Met Thr Ala Thr Gln Leu Leu Val Pro Ser 
        515                 520                 525             


Arg Arg 
    530 


<210>  2
<211>  5060
<212>  DNA
<213>  Homo sapiens

<400>  2
atgtgtgctg gtgaatgtga gtacagggaa gcagcggccg ccatttcagg gagcttgtcg       60

acgctgtcgc aggggtggat cctgagctgc cgaagccgcc gtcctgctct cccgcgtggg      120

cttctctaat tccattgttt tttttagatt ctctcgggcc tagccgtcct tggaacccga      180

tattcgggct gggcggttcc gcggcctggg cctaggggct taacagtagc aacagaagcg      240

gcggcggcgg cagcagcagc agcagcagca gcaatctctt cccgaacacg agcaccacag      300

gcgcccgaag gccggaacag gcgtttagag aaaatggcag acgatattga tattgaagca      360

atgcttgagg ctccttacaa gaaggatgag aacaagttga gcagtgccaa cggccatgaa      420

gaacgtagca aaaagaggaa aaaaagcaag agcagaagtc gtagtcatga acgaaagaga      480

agcaaaagta aggaacggaa gcgaagtaga gacagagaaa ggaaaaagag caaaagccgt      540

gaaagaaagc gaagtagaag caaagagagg cgacggagcc gctcaagaag tcgagatcga      600

agatttagag gccgctacag aagtccttac tccggaccaa aatttaacag tgccatccga      660

ggaaagattg ggttgcctca tagcatcaaa ttaagcagac gacgttcccg aagcaaaagt      720

ccattcagaa aagacaagag ccctgtgaga gaacctattg ataatttaac tcctgaggaa      780

agagatgcaa ggacagtctt ctgtatgcag ctggcggcaa gaattcgacc aagggatttg      840

gaagagtttt tctctacagt aggaaaggtt cgagatgtga ggatgatttc tgacagaaat      900

tcaagacgtt ccaaaggaat tgcttatgtg gagttcgtcg atgttagctc agtgcctcta      960

gcaataggat taactggcca acgagtttta ggcgtgccaa tcatagtaca ggcatcacag     1020

gcagaaaaaa acagagctgc agcaatggca aacaatttac aaaagggaag tgctggacct     1080

atgaggcttt atgtgggctc attacacttc aacataactg aagatatgct tcgtgggatc     1140

tttgagcctt ttggaagaat tgaaagtatc cagctgatga tggacagtga aactggtcga     1200

tccaagggat atggatttat tacattttct gactcagaat gtgccaaaaa ggctttggaa     1260

caacttaatg gatttgaact agcaggaaga ccaatgaaag ttggtcatgt tactgaacgt     1320

actgatgctt cgagtgctag ttcatttttg gacagtgatg aactggaaag gactggaatt     1380

gatttgggaa caactggtcg tcttcagtta atggcaagac ttgcagaggg tacaggtttg     1440

cagattccgc cagcagcaca gcaagctcta cagatgagtg gctctttggc atttggtgct     1500

gtggcagaat tctcttttgt tatagatttg caaacaagac tttcccagca gactgaagct     1560

tcagctttag ctgcagctgc ctctgttcag ccacttgcaa cacaatgttt ccaactctct     1620

aacatgttta accctcaaac agaagaagaa gttggatggg ataccgagat taaggatgat     1680

gtgattgaag aatgtaataa acatggagga gttattcata tttatgttga caaaaattca     1740

gctcagggca atgtgtatgt gaagtgccca tcaattgctg cagctattgc tgctgtcaat     1800

gcattgcatg gcaggtggtt tgctggtaaa atgataacag cagcatatgt acctcttcca     1860

acttaccaca acctgtttcc tgattctatg acagcaacac agctactggt tccaagtaga     1920

cgatgaagga agatatagtc ccttatgtat atagcttttt ttctttcttg agaattcatc     1980

ttgagttatc ttttatttag ataaaaataa agaggcaagg atctactgtc atttgtatgc     2040

aatttcctgt taccttgaaa aaataaaaat gttaacagga atgcagtgtg ctcattctcc     2100

ctaaatagta aatcccactg tatacaaaac tgttctcttg ttctgccttt taaaatgttc     2160

atgtagaaaa ttaatgaact ataggaatag ctctaggaga acaaatgtgc tttctgtaaa     2220

aaggcagacc agggatgtaa tgtttttaat gtttcagaag cctaactttt tacacagtgg     2280

ttacatttca catttcacta atgttgatat ttggctgatg gttgagcagt ttctgaaata     2340

cacatttagt gtatggaaat acaagacagc taaagggctg tttggttagc atctcatctt     2400

gcattctgat caattggcaa gaaagggaga tttcaaaatt atatttcttg atggtatctt     2460

ttcaattaat gtatctgtaa aagtttcttt gtaaatacta tgtgttctgg tgtgtcttaa     2520

aattccaaac aaaatgatcc ctgcatttcc tgaagatgtt taaacgtgag agtctggtag     2580

gcaaagcagt ctgagaaaga aataggaaat gcagaaatag gttttgtctg gttgcatata     2640

atctttgctc tttttaagct ctgtgagctc tgaaatatat ttttgggtta cttcagtgtg     2700

tttgacaaga cagcttgata tttctatcaa acaaatgact ttcatattgc aacaatcttt     2760

gtaagaacca ctcaaataaa agtctcttaa aaaggccaca ggagatcttc atttttcaaa     2820

tgttttaaag ttacagaaat ttgagaacag aattagcttc ttttagtctc aattcagtac     2880

ttgcctcttg ggaaaatgtt ccgagtctgc ggaaacttgc cctcacgttg tcccccatga     2940

attcctttat tctattagag tctagccctg tgtattttag aagaatgtat caaaactgag     3000

gggtttacca aaaagaaaag gaaacagcct ggccttaaaa cctgggcatt cttggtctcc     3060

tgcattgtct gggcatattt atgaagaaat tttcaccatt tacaatacat acttaacaaa     3120

atggcttaac ttcaaactgg tttccaaaat tgatttatat attaatatat taaataaggt     3180

gcatatatta ctgtattaag gggttttgag ctttcatact agttgggaag caagctgtca     3240

ccatttatac tcaattctct tcaactgttt atctcttggt aaatcttttg agtaggaaat     3300

gctgctccta gcttatcttc aaatactgag ttccttacct catttgttca actttttttt     3360

ttgttagcat tgaagcacaa gttttacagg cttattcaga atttcatatc agtcgttttg     3420

tttgacattt atcccaataa ttgttctagt gatttaattt gtatggaaac tcccaaggtt     3480

caatttcttt ttctttttga gatggagtct tgctctttgg cccaggctgg agtgcagtga     3540

tgtgatctca gctccatctc ccaggttcaa gcaattctcc cacctcagtc tcctgaagag     3600

ctgggacagg tgcgcaccac cgtgcccagc taatttttgt atttttagca gagacggtgt     3660

tagcccggct ggtctcacac tgacctcaag tgatctgtcc gccttggcct cccaaagtgc     3720

cgggattaca ggcatgagcc accgcgccca gcctcattga aaatttactt ttcaatacca     3780

gactgcagag ttctttgggg cagagacact ctgtcagtgt gctctttttc caaagtatct     3840

cctgctatca gtttttcccc ttgaaccaag tcttcctaac aaatttgttg tgtcattgct     3900

ttctagggaa ctggaccagc aaatgtggcc tttagtggtt aatctcatct gtgccaaaat     3960

ttagttgcta ccagagtgaa atttggtgtg taaataatgt tcagaggaaa tgtggttgga     4020

gtgtagtaac ttgaatagtg tcgtgcatag aaaacagctc attctgagtg aaactgttta     4080

tgtccaatca gttcctgagt cagcatccca ctggttcgaa aatctgtaac taatctggta     4140

atgtccttaa tttcctcctg cctgtcagtg ttccaaagtg ttcatctagt tttcttttat     4200

ctttataata attactacca tctttgaaag ttctgtttaa gaaatgctta atgggcaatg     4260

cgggttagta actccagggt ctgcgtggcc tgggcaggtg agatggacaa ctgcctcatt     4320

acagaagctt tttatcatca aactagtaag ttttgtggag ggcaagctat atagattgtt     4380

gatgagtggt tagaaaatca tctggaattt agccagttga gaagctacag aagtttctat     4440

ttttttttac agtggatgaa ctgttttgct ttttctgata aagccactag gtatatctaa     4500

ataacaacct cgggctggac gtggtgcctt atgcctgtat atgtgaacac tgggaggcgg     4560

aggcgggtgg atcatgaggt caagagtttg agaccagcct ggccaacaca gtgaaacccc     4620

gtctctacta agaatacaaa ttttttttgt tttgagacag agtctcgctc tgtcgcccag     4680

gctggagtgc aatggctcga tctcagctca ctgcaacctc caccttctgg gttcaagcga     4740

ttctcctgcc tcagcctccc gagtagctgg gaatacaggc gcgtgtcaac acacccggct     4800

taagtttttg tatttttagt agagacgggg tgtcaccgtg ttacccaaga tggtctccat     4860

ctcctgacct tgtgatccac cagcctttgc ctcccaaagt gctgggatta caggcataag     4920

ccaccgcgcc cagcctaaca atacaaaatt tagctaggca tggtggcacg tgcctgttat     4980

cacagctact cgggaggctg aggcaggaga aacgcttgaa cacaggaggc agaagttgcg     5040

gtaagccgag atcgtgccac                                                 5060


<210>  3
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15      


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30          


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45              


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60                  


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95      


Ser Pro Tyr Ser Gly Pro Lys Phe Asn Ser Ala Ile Arg Gly Lys Ile 
            100                 105                 110         


Gly Leu Pro His Ser Ile Lys Leu Ser Arg Arg Arg Ser Arg Ser Lys 
        115                 120                 125             


Ser Pro Phe Arg Lys Asp Lys Ser Pro Val Arg Glu Pro Ile Asp Asn 
    130                 135                 140                 


Leu Thr Pro Glu Glu Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu 
145                 150                 155                 160 


Ala Ala Arg Ile Arg Pro Arg Asp Leu Glu Glu Phe Phe Ser Thr Val 
                165                 170                 175     


Gly Lys Val Arg Asp Val Arg Met Ile Ser Asp Arg Asn Ser Arg Arg 
            180                 185                 190         


Ser Lys Gly Ile Ala Tyr Val Glu Phe Val Asp Val Ser Ser Val Pro 
        195                 200                 205             


Leu Ala Ile Gly Leu Thr Gly Gln Arg Val Leu Gly Val Pro Ile Ile 
    210                 215                 220                 


Val Gln Ala Ser Gln Ala Glu Lys Asn Arg Ala Ala Ala Met Ala Asn 
225                 230                 235                 240 


Asn Leu Gln Lys Gly Ser Ala Gly Pro Met Arg Leu Tyr Val Gly Ser 
                245                 250                 255     


Leu His Phe Asn Ile Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro 
            260                 265                 270         


Phe Gly Arg Ile Glu Ser Ile Gln Leu Met Met Asp Ser Glu Thr Gly 
        275                 280                 285             


Arg Ser Lys Gly Tyr Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala 
    290                 295                 300                 


Lys Lys Ala Leu Glu Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro 
305                 310                 315                 320 


Met Lys Val Gly His Val Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser 
                325                 330                 335     


Ser Phe Leu Asp Ser Asp Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly 
            340                 345                 350         


Thr Thr Gly Arg Leu Gln Leu Met Ala Arg Leu Ala Glu Gly Thr Gly 
        355                 360                 365             


Leu Gln Ile Pro Pro Ala Ala Gln Gln Ala Leu Gln Met Ser Gly Ser 
    370                 375                 380                 


Leu Ala Phe Gly Ala Val Ala Asp Leu Gln Thr Arg Leu Ser Gln Gln 
385                 390                 395                 400 


Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala Ser Val Gln Pro Leu Ala 
                405                 410                 415     


Thr Gln Cys Phe Gln Leu Ser Asn Met Phe Asn Pro Gln Thr Glu Glu 
            420                 425                 430         


Glu Val Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
        435                 440                 445             


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
    450                 455                 460                 


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
465                 470                 475                 480 


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 
                485                 490                 495     


Ala Ala Tyr Val Pro Leu Pro Thr Tyr His Asn Leu Phe Pro Asp Ser 
            500                 505                 510         


Met Thr Ala Thr Gln Leu Leu Val Pro Ser Arg Arg 
        515                 520                 


<210>  4
<211>  5042
<212>  DNA
<213>  Homo sapiens

<400>  4
atgtgtgctg gtgaatgtga gtacagggaa gcagcggccg ccatttcagg gagcttgtcg       60

acgctgtcgc aggggtggat cctgagctgc cgaagccgcc gtcctgctct cccgcgtggg      120

cttctctaat tccattgttt tttttagatt ctctcgggcc tagccgtcct tggaacccga      180

tattcgggct gggcggttcc gcggcctggg cctaggggct taacagtagc aacagaagcg      240

gcggcggcgg cagcagcagc agcagcagca gcaatctctt cccgaacacg agcaccacag      300

gcgcccgaag gccggaacag gcgtttagag aaaatggcag acgatattga tattgaagca      360

atgcttgagg ctccttacaa gaaggatgag aacaagttga gcagtgccaa cggccatgaa      420

gaacgtagca aaaagaggaa aaaaagcaag agcagaagtc gtagtcatga acgaaagaga      480

agcaaaagta aggaacggaa gcgaagtaga gacagagaaa ggaaaaagag caaaagccgt      540

gaaagaaagc gaagtagaag caaagagagg cgacggagcc gctcaagaag tcgagatcga      600

agatttagag gccgctacag aagtccttac tccggaccaa aatttaacag tgccatccga      660

ggaaagattg ggttgcctca tagcatcaaa ttaagcagac gacgttcccg aagcaaaagt      720

ccattcagaa aagacaagag ccctgtgaga gaacctattg ataatttaac tcctgaggaa      780

agagatgcaa ggacagtctt ctgtatgcag ctggcggcaa gaattcgacc aagggatttg      840

gaagagtttt tctctacagt aggaaaggtt cgagatgtga ggatgatttc tgacagaaat      900

tcaagacgtt ccaaaggaat tgcttatgtg gagttcgtcg atgttagctc agtgcctcta      960

gcaataggat taactggcca acgagtttta ggcgtgccaa tcatagtaca ggcatcacag     1020

gcagaaaaaa acagagctgc agcaatggca aacaatttac aaaagggaag tgctggacct     1080

atgaggcttt atgtgggctc attacacttc aacataactg aagatatgct tcgtgggatc     1140

tttgagcctt ttggaagaat tgaaagtatc cagctgatga tggacagtga aactggtcga     1200

tccaagggat atggatttat tacattttct gactcagaat gtgccaaaaa ggctttggaa     1260

caacttaatg gatttgaact agcaggaaga ccaatgaaag ttggtcatgt tactgaacgt     1320

actgatgctt cgagtgctag ttcatttttg gacagtgatg aactggaaag gactggaatt     1380

gatttgggaa caactggtcg tcttcagtta atggcaagac ttgcagaggg tacaggtttg     1440

cagattccgc cagcagcaca gcaagctcta cagatgagtg gctctttggc atttggtgct     1500

gtggcagatt tgcaaacaag actttcccag cagactgaag cttcagcttt agctgcagct     1560

gcctctgttc agccacttgc aacacaatgt ttccaactct ctaacatgtt taaccctcaa     1620

acagaagaag aagttggatg ggataccgag attaaggatg atgtgattga agaatgtaat     1680

aaacatggag gagttattca tatttatgtt gacaaaaatt cagctcaggg caatgtgtat     1740

gtgaagtgcc catcaattgc tgcagctatt gctgctgtca atgcattgca tggcaggtgg     1800

tttgctggta aaatgataac agcagcatat gtacctcttc caacttacca caacctgttt     1860

cctgattcta tgacagcaac acagctactg gttccaagta gacgatgaag gaagatatag     1920

tcccttatgt atatagcttt ttttctttct tgagaattca tcttgagtta tcttttattt     1980

agataaaaat aaagaggcaa ggatctactg tcatttgtat gcaatttcct gttaccttga     2040

aaaaataaaa atgttaacag gaatgcagtg tgctcattct ccctaaatag taaatcccac     2100

tgtatacaaa actgttctct tgttctgcct tttaaaatgt tcatgtagaa aattaatgaa     2160

ctataggaat agctctagga gaacaaatgt gctttctgta aaaaggcaga ccagggatgt     2220

aatgttttta atgtttcaga agcctaactt tttacacagt ggttacattt cacatttcac     2280

taatgttgat atttggctga tggttgagca gtttctgaaa tacacattta gtgtatggaa     2340

atacaagaca gctaaagggc tgtttggtta gcatctcatc ttgcattctg atcaattggc     2400

aagaaaggga gatttcaaaa ttatatttct tgatggtatc ttttcaatta atgtatctgt     2460

aaaagtttct ttgtaaatac tatgtgttct ggtgtgtctt aaaattccaa acaaaatgat     2520

ccctgcattt cctgaagatg tttaaacgtg agagtctggt aggcaaagca gtctgagaaa     2580

gaaataggaa atgcagaaat aggttttgtc tggttgcata taatctttgc tctttttaag     2640

ctctgtgagc tctgaaatat atttttgggt tacttcagtg tgtttgacaa gacagcttga     2700

tatttctatc aaacaaatga ctttcatatt gcaacaatct ttgtaagaac cactcaaata     2760

aaagtctctt aaaaaggcca caggagatct tcatttttca aatgttttaa agttacagaa     2820

atttgagaac agaattagct tcttttagtc tcaattcagt acttgcctct tgggaaaatg     2880

ttccgagtct gcggaaactt gccctcacgt tgtcccccat gaattccttt attctattag     2940

agtctagccc tgtgtatttt agaagaatgt atcaaaactg aggggtttac caaaaagaaa     3000

aggaaacagc ctggccttaa aacctgggca ttcttggtct cctgcattgt ctgggcatat     3060

ttatgaagaa attttcacca tttacaatac atacttaaca aaatggctta acttcaaact     3120

ggtttccaaa attgatttat atattaatat attaaataag gtgcatatat tactgtatta     3180

aggggttttg agctttcata ctagttggga agcaagctgt caccatttat actcaattct     3240

cttcaactgt ttatctcttg gtaaatcttt tgagtaggaa atgctgctcc tagcttatct     3300

tcaaatactg agttccttac ctcatttgtt caactttttt ttttgttagc attgaagcac     3360

aagttttaca ggcttattca gaatttcata tcagtcgttt tgtttgacat ttatcccaat     3420

aattgttcta gtgatttaat ttgtatggaa actcccaagg ttcaatttct ttttcttttt     3480

gagatggagt cttgctcttt ggcccaggct ggagtgcagt gatgtgatct cagctccatc     3540

tcccaggttc aagcaattct cccacctcag tctcctgaag agctgggaca ggtgcgcacc     3600

accgtgccca gctaattttt gtatttttag cagagacggt gttagcccgg ctggtctcac     3660

actgacctca agtgatctgt ccgccttggc ctcccaaagt gccgggatta caggcatgag     3720

ccaccgcgcc cagcctcatt gaaaatttac ttttcaatac cagactgcag agttctttgg     3780

ggcagagaca ctctgtcagt gtgctctttt tccaaagtat ctcctgctat cagtttttcc     3840

ccttgaacca agtcttccta acaaatttgt tgtgtcattg ctttctaggg aactggacca     3900

gcaaatgtgg cctttagtgg ttaatctcat ctgtgccaaa atttagttgc taccagagtg     3960

aaatttggtg tgtaaataat gttcagagga aatgtggttg gagtgtagta acttgaatag     4020

tgtcgtgcat agaaaacagc tcattctgag tgaaactgtt tatgtccaat cagttcctga     4080

gtcagcatcc cactggttcg aaaatctgta actaatctgg taatgtcctt aatttcctcc     4140

tgcctgtcag tgttccaaag tgttcatcta gttttctttt atctttataa taattactac     4200

catctttgaa agttctgttt aagaaatgct taatgggcaa tgcgggttag taactccagg     4260

gtctgcgtgg cctgggcagg tgagatggac aactgcctca ttacagaagc tttttatcat     4320

caaactagta agttttgtgg agggcaagct atatagattg ttgatgagtg gttagaaaat     4380

catctggaat ttagccagtt gagaagctac agaagtttct attttttttt acagtggatg     4440

aactgttttg ctttttctga taaagccact aggtatatct aaataacaac ctcgggctgg     4500

acgtggtgcc ttatgcctgt atatgtgaac actgggaggc ggaggcgggt ggatcatgag     4560

gtcaagagtt tgagaccagc ctggccaaca cagtgaaacc ccgtctctac taagaataca     4620

aatttttttt gttttgagac agagtctcgc tctgtcgccc aggctggagt gcaatggctc     4680

gatctcagct cactgcaacc tccaccttct gggttcaagc gattctcctg cctcagcctc     4740

ccgagtagct gggaatacag gcgcgtgtca acacacccgg cttaagtttt tgtattttta     4800

gtagagacgg ggtgtcaccg tgttacccaa gatggtctcc atctcctgac cttgtgatcc     4860

accagccttt gcctcccaaa gtgctgggat tacaggcata agccaccgcg cccagcctaa     4920

caatacaaaa tttagctagg catggtggca cgtgcctgtt atcacagcta ctcgggaggc     4980

tgaggcagga gaaacgcttg aacacaggag gcagaagttg cggtaagccg agatcgtgcc     5040

ac                                                                    5042


<210>  5
<211>  508
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Asp Asp Ile Asp Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys 
1               5                   10                  15      


Lys Asp Glu Asn Lys Leu Ser Ser Ala Asn Gly His Glu Glu Arg Ser 
            20                  25                  30          


Lys Lys Arg Lys Lys Ser Lys Ser Arg Ser Arg Ser His Glu Arg Lys 
        35                  40                  45              


Arg Ser Lys Ser Lys Glu Arg Lys Arg Ser Arg Asp Arg Glu Arg Lys 
    50                  55                  60                  


Lys Ser Lys Ser Arg Glu Arg Lys Arg Ser Arg Ser Lys Glu Arg Arg 
65                  70                  75                  80  


Arg Ser Arg Ser Arg Ser Arg Asp Arg Arg Phe Arg Gly Arg Tyr Arg 
                85                  90                  95      


Ser Pro Tyr Arg Arg Arg Ser Arg Ser Lys Ser Pro Phe Arg Lys Asp 
            100                 105                 110         


Lys Ser Pro Val Arg Glu Pro Ile Asp Asn Leu Thr Pro Glu Glu Arg 
        115                 120                 125             


Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg Ile Arg Pro 
    130                 135                 140                 


Arg Asp Leu Glu Glu Phe Phe Ser Thr Val Gly Lys Val Arg Asp Val 
145                 150                 155                 160 


Arg Met Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly Ile Ala Tyr 
                165                 170                 175     


Val Glu Phe Val Asp Val Ser Ser Val Pro Leu Ala Ile Gly Leu Thr 
            180                 185                 190         


Gly Gln Arg Val Leu Gly Val Pro Ile Ile Val Gln Ala Ser Gln Ala 
        195                 200                 205             


Glu Lys Asn Arg Ala Ala Ala Met Ala Asn Asn Leu Gln Lys Gly Ser 
    210                 215                 220                 


Ala Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr 
225                 230                 235                 240 


Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser 
                245                 250                 255     


Ile Gln Leu Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly 
            260                 265                 270         


Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala Lys Lys Ala Leu Glu Gln 
        275                 280                 285             


Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro Met Lys Val Gly His Val 
    290                 295                 300                 


Thr Glu Arg Thr Asp Ala Ser Ser Ala Ser Ser Phe Leu Asp Ser Asp 
305                 310                 315                 320 


Glu Leu Glu Arg Thr Gly Ile Asp Leu Gly Thr Thr Gly Arg Leu Gln 
                325                 330                 335     


Leu Met Ala Arg Leu Ala Glu Gly Thr Gly Leu Gln Ile Pro Pro Ala 
            340                 345                 350         


Ala Gln Gln Ala Leu Gln Met Ser Gly Ser Leu Ala Phe Gly Ala Val 
        355                 360                 365             


Ala Glu Phe Ser Phe Val Ile Asp Leu Gln Thr Arg Leu Ser Gln Gln 
    370                 375                 380                 


Thr Glu Ala Ser Ala Leu Ala Ala Ala Ala Ser Val Gln Pro Leu Ala 
385                 390                 395                 400 


Thr Gln Cys Phe Gln Leu Ser Asn Met Phe Asn Pro Gln Thr Glu Glu 
                405                 410                 415     


Glu Val Gly Trp Asp Thr Glu Ile Lys Asp Asp Val Ile Glu Glu Cys 
            420                 425                 430         


Asn Lys His Gly Gly Val Ile His Ile Tyr Val Asp Lys Asn Ser Ala 
        435                 440                 445             


Gln Gly Asn Val Tyr Val Lys Cys Pro Ser Ile Ala Ala Ala Ile Ala 
    450                 455                 460                 


Ala Val Asn Ala Leu His Gly Arg Trp Phe Ala Gly Lys Met Ile Thr 
465                 470                 475                 480 


Ala Ala Tyr Val Pro Leu Pro Thr Tyr His Asn Leu Phe Pro Asp Ser 
                485                 490                 495     


Met Thr Ala Thr Gln Leu Leu Val Pro Ser Arg Arg 
            500                 505             


<210>  6
<211>  4994
<212>  DNA
<213>  Homo sapiens

<400>  6
atgtgtgctg gtgaatgtga gtacagggaa gcagcggccg ccatttcagg gagcttgtcg       60

acgctgtcgc aggggtggat cctgagctgc cgaagccgcc gtcctgctct cccgcgtggg      120

cttctctaat tccattgttt tttttagatt ctctcgggcc tagccgtcct tggaacccga      180

tattcgggct gggcggttcc gcggcctggg cctaggggct taacagtagc aacagaagcg      240

gcggcggcgg cagcagcagc agcagcagca gcaatctctt cccgaacacg agcaccacag      300

gcgcccgaag gccggaacag gcgtttagag aaaatggcag acgatattga tattgaagca      360

atgcttgagg ctccttacaa gaaggatgag aacaagttga gcagtgccaa cggccatgaa      420

gaacgtagca aaaagaggaa aaaaagcaag agcagaagtc gtagtcatga acgaaagaga      480

agcaaaagta aggaacggaa gcgaagtaga gacagagaaa ggaaaaagag caaaagccgt      540

gaaagaaagc gaagtagaag caaagagagg cgacggagcc gctcaagaag tcgagatcga      600

agatttagag gccgctacag aagtccttac agacgacgtt cccgaagcaa aagtccattc      660

agaaaagaca agagccctgt gagagaacct attgataatt taactcctga ggaaagagat      720

gcaaggacag tcttctgtat gcagctggcg gcaagaattc gaccaaggga tttggaagag      780

tttttctcta cagtaggaaa ggttcgagat gtgaggatga tttctgacag aaattcaaga      840

cgttccaaag gaattgctta tgtggagttc gtcgatgtta gctcagtgcc tctagcaata      900

ggattaactg gccaacgagt tttaggcgtg ccaatcatag tacaggcatc acaggcagaa      960

aaaaacagag ctgcagcaat ggcaaacaat ttacaaaagg gaagtgctgg acctatgagg     1020

ctttatgtgg gctcattaca cttcaacata actgaagata tgcttcgtgg gatctttgag     1080

ccttttggaa gaattgaaag tatccagctg atgatggaca gtgaaactgg tcgatccaag     1140

ggatatggat ttattacatt ttctgactca gaatgtgcca aaaaggcttt ggaacaactt     1200

aatggatttg aactagcagg aagaccaatg aaagttggtc atgttactga acgtactgat     1260

gcttcgagtg ctagttcatt tttggacagt gatgaactgg aaaggactgg aattgatttg     1320

ggaacaactg gtcgtcttca gttaatggca agacttgcag agggtacagg tttgcagatt     1380

ccgccagcag cacagcaagc tctacagatg agtggctctt tggcatttgg tgctgtggca     1440

gaattctctt ttgttataga tttgcaaaca agactttccc agcagactga agcttcagct     1500

ttagctgcag ctgcctctgt tcagccactt gcaacacaat gtttccaact ctctaacatg     1560

tttaaccctc aaacagaaga agaagttgga tgggataccg agattaagga tgatgtgatt     1620

gaagaatgta ataaacatgg aggagttatt catatttatg ttgacaaaaa ttcagctcag     1680

ggcaatgtgt atgtgaagtg cccatcaatt gctgcagcta ttgctgctgt caatgcattg     1740

catggcaggt ggtttgctgg taaaatgata acagcagcat atgtacctct tccaacttac     1800

cacaacctgt ttcctgattc tatgacagca acacagctac tggttccaag tagacgatga     1860

aggaagatat agtcccttat gtatatagct ttttttcttt cttgagaatt catcttgagt     1920

tatcttttat ttagataaaa ataaagaggc aaggatctac tgtcatttgt atgcaatttc     1980

ctgttacctt gaaaaaataa aaatgttaac aggaatgcag tgtgctcatt ctccctaaat     2040

agtaaatccc actgtataca aaactgttct cttgttctgc cttttaaaat gttcatgtag     2100

aaaattaatg aactatagga atagctctag gagaacaaat gtgctttctg taaaaaggca     2160

gaccagggat gtaatgtttt taatgtttca gaagcctaac tttttacaca gtggttacat     2220

ttcacatttc actaatgttg atatttggct gatggttgag cagtttctga aatacacatt     2280

tagtgtatgg aaatacaaga cagctaaagg gctgtttggt tagcatctca tcttgcattc     2340

tgatcaattg gcaagaaagg gagatttcaa aattatattt cttgatggta tcttttcaat     2400

taatgtatct gtaaaagttt ctttgtaaat actatgtgtt ctggtgtgtc ttaaaattcc     2460

aaacaaaatg atccctgcat ttcctgaaga tgtttaaacg tgagagtctg gtaggcaaag     2520

cagtctgaga aagaaatagg aaatgcagaa ataggttttg tctggttgca tataatcttt     2580

gctcttttta agctctgtga gctctgaaat atatttttgg gttacttcag tgtgtttgac     2640

aagacagctt gatatttcta tcaaacaaat gactttcata ttgcaacaat ctttgtaaga     2700

accactcaaa taaaagtctc ttaaaaaggc cacaggagat cttcattttt caaatgtttt     2760

aaagttacag aaatttgaga acagaattag cttcttttag tctcaattca gtacttgcct     2820

cttgggaaaa tgttccgagt ctgcggaaac ttgccctcac gttgtccccc atgaattcct     2880

ttattctatt agagtctagc cctgtgtatt ttagaagaat gtatcaaaac tgaggggttt     2940

accaaaaaga aaaggaaaca gcctggcctt aaaacctggg cattcttggt ctcctgcatt     3000

gtctgggcat atttatgaag aaattttcac catttacaat acatacttaa caaaatggct     3060

taacttcaaa ctggtttcca aaattgattt atatattaat atattaaata aggtgcatat     3120

attactgtat taaggggttt tgagctttca tactagttgg gaagcaagct gtcaccattt     3180

atactcaatt ctcttcaact gtttatctct tggtaaatct tttgagtagg aaatgctgct     3240

cctagcttat cttcaaatac tgagttcctt acctcatttg ttcaactttt ttttttgtta     3300

gcattgaagc acaagtttta caggcttatt cagaatttca tatcagtcgt tttgtttgac     3360

atttatccca ataattgttc tagtgattta atttgtatgg aaactcccaa ggttcaattt     3420

ctttttcttt ttgagatgga gtcttgctct ttggcccagg ctggagtgca gtgatgtgat     3480

ctcagctcca tctcccaggt tcaagcaatt ctcccacctc agtctcctga agagctggga     3540

caggtgcgca ccaccgtgcc cagctaattt ttgtattttt agcagagacg gtgttagccc     3600

ggctggtctc acactgacct caagtgatct gtccgccttg gcctcccaaa gtgccgggat     3660

tacaggcatg agccaccgcg cccagcctca ttgaaaattt acttttcaat accagactgc     3720

agagttcttt ggggcagaga cactctgtca gtgtgctctt tttccaaagt atctcctgct     3780

atcagttttt ccccttgaac caagtcttcc taacaaattt gttgtgtcat tgctttctag     3840

ggaactggac cagcaaatgt ggcctttagt ggttaatctc atctgtgcca aaatttagtt     3900

gctaccagag tgaaatttgg tgtgtaaata atgttcagag gaaatgtggt tggagtgtag     3960

taacttgaat agtgtcgtgc atagaaaaca gctcattctg agtgaaactg tttatgtcca     4020

atcagttcct gagtcagcat cccactggtt cgaaaatctg taactaatct ggtaatgtcc     4080

ttaatttcct cctgcctgtc agtgttccaa agtgttcatc tagttttctt ttatctttat     4140

aataattact accatctttg aaagttctgt ttaagaaatg cttaatgggc aatgcgggtt     4200

agtaactcca gggtctgcgt ggcctgggca ggtgagatgg acaactgcct cattacagaa     4260

gctttttatc atcaaactag taagttttgt ggagggcaag ctatatagat tgttgatgag     4320

tggttagaaa atcatctgga atttagccag ttgagaagct acagaagttt ctattttttt     4380

ttacagtgga tgaactgttt tgctttttct gataaagcca ctaggtatat ctaaataaca     4440

acctcgggct ggacgtggtg ccttatgcct gtatatgtga acactgggag gcggaggcgg     4500

gtggatcatg aggtcaagag tttgagacca gcctggccaa cacagtgaaa ccccgtctct     4560

actaagaata caaatttttt ttgttttgag acagagtctc gctctgtcgc ccaggctgga     4620

gtgcaatggc tcgatctcag ctcactgcaa cctccacctt ctgggttcaa gcgattctcc     4680

tgcctcagcc tcccgagtag ctgggaatac aggcgcgtgt caacacaccc ggcttaagtt     4740

tttgtatttt tagtagagac ggggtgtcac cgtgttaccc aagatggtct ccatctcctg     4800

accttgtgat ccaccagcct ttgcctccca aagtgctggg attacaggca taagccaccg     4860

cgcccagcct aacaatacaa aatttagcta ggcatggtgg cacgtgcctg ttatcacagc     4920

tactcgggag gctgaggcag gagaaacgct tgaacacagg aggcagaagt tgcggtaagc     4980

cgagatcgtg ccac                                                       4994


<210>  7
<211>  449
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Ser Cys Ser Val Thr Gln Ala Gly Ala Gln Trp Arg Val Leu 
1               5                   10                  15      


Gly Ser Leu Gln Pro Pro Pro Pro Gly Phe Lys Gln Phe Leu Cys His 
            20                  25                  30          


Ser Leu Pro Ser Ser Trp Asp Tyr Arg Ser Asp Arg Met Ala Ser Asp 
        35                  40                  45              


Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala Pro Tyr Lys Lys 
    50                  55                  60                  


Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys Asp Tyr Pro Ser 
65                  70                  75                  80  


Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu Thr Ser Gly Ser 
                85                  90                  95      


Ser Thr Ile Gly Glu Thr Ser Asn Arg Ser Arg Asp Arg Asp Arg Tyr 
            100                 105                 110         


Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg Gln Cys Arg His 
        115                 120                 125             


Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu Ser Arg Ser Arg 
    130                 135                 140                 


Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser Pro Pro Leu Ala 
145                 150                 155                 160 


Thr Gly Glu Pro Val Asp Asn Leu Ser Pro Glu Glu Arg Asp Ala Arg 
                165                 170                 175     


Thr Val Phe Cys Met Gln Leu Ala Ala Arg Ile Arg Pro Arg Asp Leu 
            180                 185                 190         


Glu Asp Phe Phe Ser Ala Val Gly Lys Val Arg Asp Val Arg Ile Ile 
        195                 200                 205             


Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly Ile Ala Tyr Val Glu Phe 
    210                 215                 220                 


Cys Glu Ile Gln Ser Val Pro Leu Ala Ile Gly Leu Thr Gly Gln Arg 
225                 230                 235                 240 


Leu Leu Gly Val Pro Ile Ile Val Gln Ala Ser Gln Ala Glu Lys Asn 
                245                 250                 255     


Arg Leu Ala Ala Met Ala Asn Asn Leu Gln Lys Gly Asn Gly Gly Pro 
            260                 265                 270         


Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
        275                 280                 285             


Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys Ile Asp Asn Ile Val Leu 
    290                 295                 300                 


Met Lys Asp Ser Asp Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
305                 310                 315                 320 


Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala Leu Glu Gln Leu Asn Gly 
                325                 330                 335     


Phe Glu Leu Ala Gly Arg Pro Met Arg Val Gly His Val Thr Glu Arg 
            340                 345                 350         


Leu Asp Gly Gly Thr Asp Ile Thr Phe Pro Asp Gly Asp Gln Glu Leu 
        355                 360                 365             


Asp Leu Gly Ser Ala Gly Gly Arg Phe Gln Leu Met Ala Lys Leu Ala 
    370                 375                 380                 


Glu Gly Ala Gly Ile Gln Leu Pro Ser Thr Ala Ala Ala Ala Ala Ala 
385                 390                 395                 400 


Ala Ala Ala Gln Ala Ala Ala Leu Gln Leu Asn Gly Ala Val Pro Leu 
                405                 410                 415     


Gly Ala Leu Asn Pro Ala Ala Leu Thr Ala Leu Ser Pro Ala Leu Asn 
            420                 425                 430         


Leu Ala Ser Gln Cys Phe Gln Leu Ser Ser Leu Phe Thr Pro Gln Thr 
        435                 440                 445             


Met 
    


<210>  8
<211>  10178
<212>  DNA
<213>  Homo sapiens

<400>  8
agagctgccg ccattttgcg ggaagaggag gctctgtacc tgcagtgctg cttttcttgc       60

ctagactcta ggaactatcc gagctccact ccccacaaca tactcaaagg aacggagaga      120

accgggaccc ccctgcgggg acccggaact ggatggaaga aaacatactc tatgtggatg      180

agattgagtg gaccttgacc cataagttgg gacatgaaga gagcgtttga aaactaccaa      240

cctgggccgg gtgcagtggc tcacgcctgt aatcccagca ctttgggtgg ccgaggcggg      300

cggatcacga ggtcaggaga tcgcgaccat cctggctaac acggcgaaac cccgtctcta      360

ctaaaaatac aaaaaaaaaa caaaaaagaa gaaaaaagaa aaaactacca gcctgaaaat      420

gcatagtgtt tgctacctta ttgcttttag cacatctaga aagacactaa acccagtgag      480

attatctgac aggatggcat ctgatgactt tgacatagtg attgaggcca tgctggaagc      540

tccctataaa aaagaagagt cgtagtcgag atcgggatcg gtatagacgg agaaatagtc      600

ggagccgaag tccaggtcgg cagtgtcgtc accgtagccg tagctgggat cgtcgacatg      660

gtagtgagtc gcgaagtcgg gaccatcgtc gtgaggatcg tgtgcattac aggagtcctc      720

cacttgccac tggttatagg tatggacaca gtaagagtcc tcatttcaga gagaagagcc      780

cagtcaggga gccagttgat aatctgagtc ctgaggagcg tgatgcccgc acagttttct      840

gtatgcagtt agctgcccga attcggcctc gagatctgga ggactttttc tctgctgtag      900

gcaaggttcg cgatgtacgt atcatctcag atcggaactc acgtcgttct aagggcattg      960

cctacgtgga attctgtgaa atccagtctg tgccactggc cattgggctg actgggcagc     1020

ggttgctggg agtgcctatc attgtacagg cttcacaggc agagaaaaac cgactggcag     1080

ccatggccaa caacctgcaa aagggcaatg gtggaccaat gcgcctctat gtgggttccc     1140

tgcacttcaa tatcactgaa gacatgctcc ggggcatctt tgagcccttt ggtaaaattg     1200

ataatattgt cctgatgaag gactcagata caggccgctc taaaggttat ggtttcatca     1260

cgttctctga ttctgagtgt gcccggcggg ccctggaaca gttgaatggg tttgagcttg     1320

ctggtcgacc tatgagggtt ggccatgtga ctgagcgact ggatggtggc acagacatca     1380

cttttcctga tggggaccag gagctggatc tgggatcagc aggtggacgt tttcagctca     1440

tggcaaaact ggcagaaggc gctggaatcc aactgccaag cactgctgct gctgctgctg     1500

ccgccgccgc ccaggctgct gccttgcaac tgaatggagc agttcccttg ggggccctga     1560

atccagcagc tctgactgct ctgagtccag ccctgaacct tgcctcccag tgtttccagc     1620

tctccagcct ctttaccccc cagaccatgt aaatcagtgg cacagtatac tgcctccttg     1680

tgcctctgga tcctgccact tcacatctac tcttccatgg ccccatttct ccattttgtg     1740

gaccaagcca tcctgagggc atggacattg tctctgagga aattggggcc acccttaaga     1800

taccaagaaa agctcctgcc catggtccca ctggaaatgg actctgctga gcaaagccac     1860

cagttgaaga gaacagaatc cacacctgca ttgaatacct gtttctccat gtgtatcgtc     1920

tctgagatta ccttcttgcc ctttccaaca ccttagtgat tcctcaattt ctcccccatt     1980

gggaaggcca tagggcatac tgaaggaact gacctctctc cttttcctgt acctttaacc     2040

tttagtctgt caaggaaaac ccttaggacc tctgaatcaa gaggactgag tttgtgggtg     2100

aaccttgaag gtgctctttc tgctacaagg gccctgggag atagcatgga cgtgcattga     2160

gaagccagcc tcagacctta gcttgaagca gcttgaggcc agacctactg tagcctcagc     2220

atcttgctag gaggcatgga agtgatctat cctgccagga ggcctcagag tgatctgtcc     2280

tgccaggagg tgtgagagtg atctgtcctg tgaggcattt aggggctttc aggaatttag     2340

taaaaggtgg agtatgcctt tccagtatct tccatcttcc tttgtatact tgtccttcct     2400

cccatttcct ccctttggcc cgaggtagga ggatggaggg aggctgctac tctaccactt     2460

cctgtgtgcc tctactgtgg cctcaaccct ggcaattata gctactccca tcccttacct     2520

gggcatgtgt gagcccttct cactggattt tatacccttg tgtctgtgta cataaatata     2580

tatacatata tatatacata aaaactttgt acaaaaggca agcctcctcc ttgtggcagc     2640

tgttgcccat ttgtgtgtgg tctttgttgt gtgtctgaca acttctcatt agcccaactt     2700

atgatgtttc tagggatata aaacattagt aacatcattg tgtttattta tttaaccacc     2760

tttagaaaga aaaatgaaaa ctcacacctg ggtggggttc ccattctgta tctgcattac     2820

actgttgatc tatggttgtc ttctccatct atcttcatcc taactatctc catcccagct     2880

acccactgga cagaattacc caaacagcca agttgcagca ccaggacaga cttagactta     2940

acaggctcct tctctgtgcc taatgacaga tctttccagc agatggcact atgacagtac     3000

tgcattctac acttgttttt ttctagtggg gcggggcggg gagggggggg ggttgtgatc     3060

ttgaagagtt aagtaccaga gctaagctga gctttcttaa ctctattggc ctttgtacct     3120

gcctttgacc ctctttgtag tagcgatccc aatccaatat ccaaaggggt ttgggtcttg     3180

tataacagca gggttctcct gacctgatgt ctactgttgt tcctctgtca gtcccctcaa     3240

ctcctgcttt ccatgtggct ctgcctggga taacacaggc ctgggaccag tgaattgtag     3300

ggaactgagt attccagaaa tacctctgtg aaagggaagg tgcacctacc actgccttaa     3360

taataagggg gtgggagaga ggctgtctca cccagcttag ggaccaaatg agaaggcctg     3420

aattcagggg cagggctctg tggggctcct tttttgatct ctatggcaac aaaatgctaa     3480

gactttctta tgctaaaaat atggataatt gctgttaggt tttaatttgt cagctctcag     3540

acttctaagc cagtgatgtt agcctctggg gttgctttta acacaaaatc atttaaatac     3600

ttgaagcctg cttgagtcat aaaaggccag tgggactcta gctcctaagt ctgtttgctg     3660

cttctgtaac aatagcacag actaatttgt aaagaaaaga ggtgtaggct gggtgcactg     3720

gctcacgcct gtaatcccag cactttggga ggccgaggtg ggtggatcac gaggtcagtt     3780

caagaccagc ctggccaaca tggtgaaact ctgtctctac tagaaataca aaaagtagct     3840

gggcatggtg gtgggtgcct gtaatcccag ctactcagga ggctgagaca ggagaatcgc     3900

ttgagcctgg gaggcggagg ttgcagtgag ccgaggatgc accactgcac tccagcctgg     3960

gcaacagagc gagcctccat ctcaaaaaaa cagaaaagtg tatttctcac agttctggag     4020

gctgggaatt tcaagagcat ggtgcctgca tcaggtgggg gtcatcccat gtcagaaggg     4080

cacaaggtag aaatgagtac atgagacaaa gggaccatgg gccaaacttg ctttataaca     4140

gccctctctc atgataacct gctgtgtgat agtgacatta atccactcat gagggctctg     4200

tccttgtgac tcagtcacct cgtattaagc cccatcttca acactgttgc attgggagtc     4260

aaatttccaa tgtgaacttt tgggggacac attcaaacca cagcatttct gattcttcca     4320

ggcctagatc tcacatgatg ttgctgttct cctggttacc acccccatcc cttcccccat     4380

cttatcctag tttgctttct ggaccggggg aaaagggaag gaggatgcac tatttttagg     4440

tagaagctgc tggctatgac ccagcacccc tacagttatt gatttggctt ctaatgtatc     4500

ttgagaagtg cagtgggtac cgtttttgtt agtcatcctg aggccatgaa ctgggtcttc     4560

tcatggctgg cttggctcct tcagactatt ataaatatcc acaggccttg cctccctgcc     4620

ttcctctgct tggtttcctt atgtttccat ccctagctac cttggccttc ctacactcgg     4680

atccttccac ctcagttctt tcttgttctt agttcctcac atagcctctt gctgggagag     4740

agacaatgtt ggaagtaagg acgtatctaa gacaatttcc agtcttactc catataaggt     4800

gatggtatct agtgagtgac agttgctgtc cgtgtgtgac tcagtgcctt cttgttactc     4860

atccctccat acgaggtggt tagagtggag agaagcgggc tgtgaacaga ctctgggccc     4920

agcttaaggt aaaagaaact tccctcaaca tctacctgca catggtggct ggtggcgtag     4980

gggtgacatt gtgatctaga tcctttgcca gcatagttag aatttcccta ccagtcttca     5040

gttctagaaa agattctcac ctgatttttg acttccagtc tatgcttctg tattcactaa     5100

ggtggcagca tttcctccct gttctttaaa ctgctgtgct cttgacacag gaattctgcc     5160

tgcttcctca gactcccaac aacccccaga taggagttac cagtagaagc agaggcttga     5220

cctgtgaact tttagtcctg gagcatatca tgaagggaat tgagtaaaaa cctgaaggat     5280

ggaattatat cacagtccct cttttccgtg taatggaaag gctttagtga aaatcaggca     5340

gcaacacttg gacagtgaaa agagactctg aaaggtgagg tgacaggagg tggcataatg     5400

gtcattgtta acatttatgc aaggttggtt gtaggttagg tgttctaatc gtgtattaag     5460

tcacaaaatc ctcacaacaa tcctctcaag tagtttatta tctttacttt gtaaacaagg     5520

aaacatatcc aaataagtta aataattttc cccataagca caaagttagc aagttaggga     5580

ttccaatcca agtactctcg cttcagatcc cttgatctta accttacctg cctctcagca     5640

ccaccatgga agacaaggcc ttggagtcag tgaggaagtg tcacttttcc tatccctgta     5700

cccatagctc tccgtagact cagaattttt ccactgccat gtctttgctt atcttgagtg     5760

acagtgtttg tgggtgaacc ttgaaggtgc tctttctgct acaagggccc tgggagatag     5820

catgggcatg tgcattgaga agccagcctc agaccttatc ttgaagcagc ttgaggccag     5880

acctactgta ggctcagcat cttgctagga ggcatgggag tgatctaacc tgccagctat     5940

ctctcttcct ttcctccttc tgctgatcaa agtcctgtcc tttaagaccc tgaagctttc     6000

ctaggtggag ttgatctctc ttttcagtat tctttgtcct cttgtgggtc atcttactct     6060

acttttattt agtaaataaa ataattgcaa taaaaattat tttattgaaa actccattac     6120

ttgatggtta cagcctgatg aggccagact tggatgtctt tctcatgatt gctttgcctt     6180

gcacatatta aatgtctgta gaattgaatg aatgctgttc attaaagtgt taaagtcagc     6240

accaggcttt ccaaaggctg ccccttctag gctgcttttc ccagcagcct catccattcc     6300

ttcctcactc caccaggaga gaagatgcag ctttactctt tctgatgtta ccatggtagc     6360

ctgtgatact ttctttctaa agtgctgctt gccatccacc agagactgat gtttccatgg     6420

caaccaggtg aaggcaatag tcacgagctg gatgcaggaa aggaattccg gtctgagaag     6480

ctgcatatct gaatcttcta gcttcagaca tcctttcccc tctctcataa cttttgcgct     6540

ttatatccag gactggtttg ctctctggtg tgcccttggt tgagagagct ctgtgaaagt     6600

gaggtgaagc agaccaacca acttagatca cgtgggaagg tgggtgcaag gaaagagctg     6660

agcaaagatc acttcaaaaa gttggatgaa gtctattagt tgttcagatg atctgctctc     6720

aagagccctt aaggagttgg ctggagtttc tggagagcca ttaagcagtt atttttgaga     6780

gcaatgggta gatggatgag gtgcctgaag actggaaagc agccagtcag tgccggattg     6840

tagaaaggag aaacaatgac cttggaaatc ggagacccgt caaacttgcc aatgttccag     6900

aaaggatggg agtttcagtc agctttcagg catcaggaag cctacttgct tagaattagt     6960

ggtgctaaga attcgcctcc tcaactcctg agcataagca agctagggga cctccaccct     7020

gtagccgagt gtcacactct ggaaccacac agcatggttc agatccctct tccctcacaa     7080

actagctgaa taagcttggg taggttactt cacttctctc acacttcatc tgtaaaaagg     7140

aaatgataac acctatctca tagggatgtt gtgagaattc attgagaaag gtttggaact     7200

tggctcatta ctgtcctcag tattttcact cctctggatg cctactcact tgattttcta     7260

gctgacttca ttctccccaa ctttagagct caaggtttat ggggaaaagc aagggcagtg     7320

caatggtgaa aataaatctt catttttaaa taaataaatt gttcctgcac tgaagcccca     7380

agcttacaag gtcttgggtc acacacaacc tgcctagttt tcaggaaaac agatcccact     7440

agcccaatct ctttatgctt gaggctctgt ccacatagtt agattttaac cagatggttt     7500

cgaaaaatca aaatgagccc ccctcacagg taccttcaag gtacctaaca ccattagctt     7560

tgtctggcag gggaaaaata ccagggcact cagttttgtt ttgttttgag acagggtctg     7620

gctctgttgc ccatgctgga gtacagtggt gccatcacag ctcactgcag tctcaacctc     7680

ctgagctcaa atgatcctct tgattagctg gaactacagg tatgtgccac tatgcccagc     7740

taagttttgt attttttgta gagatggggt cttgctatgt tgcccaggtg gtcttgaact     7800

cctgggctta agtgatcctc cctccttagc ctcccaaagt gctaggatta taggtgtgag     7860

ccaccacaac tgcctgagag caccctctgt taccaccctt tccttagcgt ctcagcctcc     7920

cccaagcacc tgtctttgtt ggtctccaga gcctagccct acactggcat tttcctttct     7980

gaataagtat tttttttatt tatttatttt tattttttct ttgagatgga gtttcgcttt     8040

tgttgcccag gctggagtgc aatggtgcga tctcggctca ccgcaacctc tgcttcctgg     8100

gttcaagtga ttctcctgcc tcagcctcct gagtagctgg gattacaggc gtgcgccacc     8160

actcccagct aattttgtat ttttagtgga gacagggttt ctccatgttg gtcaggctgg     8220

tctcgaactc ctgacctcag gtgatccacc cgccttggcc tcccaaagtg ctgggattac     8280

agtcctgagc cactgcactg ggccttattt atttattttt aattaattaa ttaatttttt     8340

ttgagatgga gtcttgcttt gtcgcccagg ctggagtgca gtggcgcaat ctcgggtcac     8400

tgcaagctct gcctcccagg ttcatgccat tctcctgcct cagcctccca agtagctggg     8460

actacaggca cctgccacta tgcccggcta attttttgta ttttttagta gagatggggt     8520

ttcactgttt tagccaggat ggtttcgatc tcctgaccta gtgatccgct cgcctcggcc     8580

tcccagagtg ctgggattac aggcgtgagc cactgcgccc ggctgggcct tatttatgta     8640

tttttctgag acagagtctc atgctatcac ccaggctgga gtgcagtggc atgatctctg     8700

ctcactgcga tctctgctca cttcaacctc tgcttcccgg gttcaagtga ttctcccacc     8760

tcagcctccc gagtagctgg aattacaggc acccaccacc atgcctggct aatttttgta     8820

atttttttta gtagaaatag ggtttcacca tgttggccag gctggtctct ctcttgacct     8880

caagtgatcc acccacctcg gcctcccaaa gtgctgggat tacaggcgtg agccaattgc     8940

ccgacctgag taagtatttt aaatcagcac aggtcctctg cttaaagtca agttgtaatt     9000

tgaacacaaa aatggaaaat catgcagtaa aataccatcg tggagcttca attgccaatc     9060

tgtcccccaa ccttccatca gatgacaaaa cccaaaaaag tgttacccgt gagtcctatg     9120

gaaggcacgt tggactttgt agaccataac ttaaattttt atctccaaat ggtgctgtgc     9180

tttgagagtt tagcaagctg ctttgatgcc taaataaagg gccaggacat aggttgcaaa     9240

aggcattact acttccaccg cttctctgta taatgcttga gaaattacaa agatctttgc     9300

tcttttattt agtcctcatg acttcgctat aaggtaggta ttcttcattt tagagttggg     9360

atagcatagc tgagttcagc aaaccagaca ggttaagagt gacttcatcc acagaccccc     9420

atccaggaaa catcctgagc actaattgaa aagcattcaa gggcttactg aatttgcatt     9480

cacatctgga gttttcaagg ccactaagct gtggaaactt gacatcaata ttcaaataga     9540

tgaaaaggga ccttaagcat atccatcagg gagtcaccga gatgataaag gcctgagaag     9600

cagtatgctc ttgtccggca tttgtgtcct ttgacgactg caccatccac ccaaattttg     9660

ctgccttctt tataggaagg gccttttcct catgtggtgg gctgcccact gtttcttctc     9720

tgtgcatttg ctcatgtagt ttgaccacaa ggaatgcttt tccttctttc tctcaactat     9780

ctatagccta catatccttt aaggcccagt ttctaaaata tgtcttccaa atttactgtt     9840

tcttccattc agaattcctg gagcacatga ggtagccccc agttagatag aatgtggtat     9900

tgtttgctgc tattttgcct gttttgtgct gtatcacctc atccatctcc ccagcttaat     9960

tgcaagctat ttgacgggca gaaattgtgt cttatttgta tttgttttcc ccattgggcc    10020

cggcacactg attggcatat tgcagatgtt tagtacttga gagaaacaaa atgtcttcta    10080

gcatttgtgg atgaaagatt aaaatgtcca ggaaaattta cttagattga tgtggattga    10140

aactatatta gattaataaa aagatgtgtg tgtgtgaa                            10178


<210>  9
<211>  405
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Asp Asp Phe Asp Ile Val Ile Glu Ala Met Leu Glu Ala 
1               5                   10                  15      


Pro Tyr Lys Lys Glu Glu Asp Glu Gln Gln Arg Lys Glu Val Lys Lys 
            20                  25                  30          


Asp Tyr Pro Ser Asn Thr Thr Ser Ser Thr Ser Asn Ser Gly Asn Glu 
        35                  40                  45              


Thr Ser Gly Ser Ser Thr Ile Gly Glu Thr Ser Asn Arg Ser Arg Asp 
    50                  55                  60                  


Arg Asp Arg Tyr Arg Arg Arg Asn Ser Arg Ser Arg Ser Pro Gly Arg 
65                  70                  75                  80  


Gln Cys Arg His Arg Ser Arg Ser Trp Asp Arg Arg His Gly Ser Glu 
                85                  90                  95      


Ser Arg Ser Arg Asp His Arg Arg Glu Asp Arg Val His Tyr Arg Ser 
            100                 105                 110         


Pro Pro Leu Ala Thr Gly Glu Pro Val Asp Asn Leu Ser Pro Glu Glu 
        115                 120                 125             


Arg Asp Ala Arg Thr Val Phe Cys Met Gln Leu Ala Ala Arg Ile Arg 
    130                 135                 140                 


Pro Arg Asp Leu Glu Asp Phe Phe Ser Ala Val Gly Lys Val Arg Asp 
145                 150                 155                 160 


Val Arg Ile Ile Ser Asp Arg Asn Ser Arg Arg Ser Lys Gly Ile Ala 
                165                 170                 175     


Tyr Val Glu Phe Cys Glu Ile Gln Ser Val Pro Leu Ala Ile Gly Leu 
            180                 185                 190         


Thr Gly Gln Arg Leu Leu Gly Val Pro Ile Ile Val Gln Ala Ser Gln 
        195                 200                 205             


Ala Glu Lys Asn Arg Leu Ala Ala Met Ala Asn Asn Leu Gln Lys Gly 
    210                 215                 220                 


Asn Gly Gly Pro Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile 
225                 230                 235                 240 


Thr Glu Asp Met Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys Ile Asp 
                245                 250                 255     


Asn Ile Val Leu Met Lys Asp Ser Asp Thr Gly Arg Ser Lys Gly Tyr 
            260                 265                 270         


Gly Phe Ile Thr Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala Leu Glu 
        275                 280                 285             


Gln Leu Asn Gly Phe Glu Leu Ala Gly Arg Pro Met Arg Val Gly His 
    290                 295                 300                 


Val Thr Glu Arg Leu Asp Gly Gly Thr Asp Ile Thr Phe Pro Asp Gly 
305                 310                 315                 320 


Asp Gln Glu Leu Asp Leu Gly Ser Ala Gly Gly Arg Phe Gln Leu Met 
                325                 330                 335     


Ala Lys Leu Ala Glu Gly Ala Gly Ile Gln Leu Pro Ser Thr Ala Ala 
            340                 345                 350         


Ala Ala Ala Ala Ala Ala Ala Gln Ala Ala Ala Leu Gln Leu Asn Gly 
        355                 360                 365             


Ala Val Pro Leu Gly Ala Leu Asn Pro Ala Ala Leu Thr Ala Leu Ser 
    370                 375                 380                 


Pro Ala Leu Asn Leu Ala Ser Gln Cys Phe Gln Leu Ser Ser Leu Phe 
385                 390                 395                 400 


Thr Pro Gln Thr Met 
                405 


<210>  10
<211>  9905
<212>  DNA
<213>  Homo sapiens

<400>  10
agagctgccg ccattttgcg ggaagaggag gctctgtacc tgcagtgctg cttttcttgc       60

ctagactcta ggaactatcc gagctccact ccccacaaca tactcaaagg aacggagaga      120

accgggaccc ccctgcgggg acccggaact gatctgacag gatggcatct gatgactttg      180

acatagtgat tgaggccatg ctggaagctc cctataaaaa agaagaggat gagcaacaaa      240

ggaaagaagt taaaaaggat tatcctagca ataccaccag cagcaccagc aacagtggca      300

atgagaccag tggaagcagc accatcgggg agacaagcaa tcgtagtcga gatcgggatc      360

ggtatagacg gagaaatagt cggagccgaa gtccaggtcg gcagtgtcgt caccgtagcc      420

gtagctggga tcgtcgacat ggtagtgagt cgcgaagtcg ggaccatcgt cgtgaggatc      480

gtgtgcatta caggagtcct ccacttgcca ctggggagcc agttgataat ctgagtcctg      540

aggagcgtga tgcccgcaca gttttctgta tgcagttagc tgcccgaatt cggcctcgag      600

atctggagga ctttttctct gctgtaggca aggttcgcga tgtacgtatc atctcagatc      660

ggaactcacg tcgttctaag ggcattgcct acgtggaatt ctgtgaaatc cagtctgtgc      720

cactggccat tgggctgact gggcagcggt tgctgggagt gcctatcatt gtacaggctt      780

cacaggcaga gaaaaaccga ctggcagcca tggccaacaa cctgcaaaag ggcaatggtg      840

gaccaatgcg cctctatgtg ggttccctgc acttcaatat cactgaagac atgctccggg      900

gcatctttga gccctttggt aaaattgata atattgtcct gatgaaggac tcagatacag      960

gccgctctaa aggttatggt ttcatcacgt tctctgattc tgagtgtgcc cggcgggccc     1020

tggaacagtt gaatgggttt gagcttgctg gtcgacctat gagggttggc catgtgactg     1080

agcgactgga tggtggcaca gacatcactt ttcctgatgg ggaccaggag ctggatctgg     1140

gatcagcagg tggacgtttt cagctcatgg caaaactggc agaaggcgct ggaatccaac     1200

tgccaagcac tgctgctgct gctgctgccg ccgccgccca ggctgctgcc ttgcaactga     1260

atggagcagt tcccttgggg gccctgaatc cagcagctct gactgctctg agtccagccc     1320

tgaaccttgc ctcccagtgt ttccagctct ccagcctctt taccccccag accatgtaaa     1380

tcagtggcac agtatactgc ctccttgtgc ctctggatcc tgccacttca catctactct     1440

tccatggccc catttctcca ttttgtggac caagccatcc tgagggcatg gacattgtct     1500

ctgaggaaat tggggccacc cttaagatac caagaaaagc tcctgcccat ggtcccactg     1560

gaaatggact ctgctgagca aagccaccag ttgaagagaa cagaatccac acctgcattg     1620

aatacctgtt tctccatgtg tatcgtctct gagattacct tcttgccctt tccaacacct     1680

tagtgattcc tcaatttctc ccccattggg aaggccatag ggcatactga aggaactgac     1740

ctctctcctt ttcctgtacc tttaaccttt agtctgtcaa ggaaaaccct taggacctct     1800

gaatcaagag gactgagttt gtgggtgaac cttgaaggtg ctctttctgc tacaagggcc     1860

ctgggagata gcatggacgt gcattgagaa gccagcctca gaccttagct tgaagcagct     1920

tgaggccaga cctactgtag cctcagcatc ttgctaggag gcatggaagt gatctatcct     1980

gccaggaggc ctcagagtga tctgtcctgc caggaggtgt gagagtgatc tgtcctgtga     2040

ggcatttagg ggctttcagg aatttagtaa aaggtggagt atgcctttcc agtatcttcc     2100

atcttccttt gtatacttgt ccttcctccc atttcctccc tttggcccga ggtaggagga     2160

tggagggagg ctgctactct accacttcct gtgtgcctct actgtggcct caaccctggc     2220

aattatagct actcccatcc cttacctggg catgtgtgag cccttctcac tggattttat     2280

acccttgtgt ctgtgtacat aaatatatat acatatatat atacataaaa actttgtaca     2340

aaaggcaagc ctcctccttg tggcagctgt tgcccatttg tgtgtggtct ttgttgtgtg     2400

tctgacaact tctcattagc ccaacttatg atgtttctag ggatataaaa cattagtaac     2460

atcattgtgt ttatttattt aaccaccttt agaaagaaaa atgaaaactc acacctgggt     2520

ggggttccca ttctgtatct gcattacact gttgatctat ggttgtcttc tccatctatc     2580

ttcatcctaa ctatctccat cccagctacc cactggacag aattacccaa acagccaagt     2640

tgcagcacca ggacagactt agacttaaca ggctccttct ctgtgcctaa tgacagatct     2700

ttccagcaga tggcactatg acagtactgc attctacact tgtttttttc tagtggggcg     2760

gggcggggag gggggggggt tgtgatcttg aagagttaag taccagagct aagctgagct     2820

ttcttaactc tattggcctt tgtacctgcc tttgaccctc tttgtagtag cgatcccaat     2880

ccaatatcca aaggggtttg ggtcttgtat aacagcaggg ttctcctgac ctgatgtcta     2940

ctgttgttcc tctgtcagtc ccctcaactc ctgctttcca tgtggctctg cctgggataa     3000

cacaggcctg ggaccagtga attgtaggga actgagtatt ccagaaatac ctctgtgaaa     3060

gggaaggtgc acctaccact gccttaataa taagggggtg ggagagaggc tgtctcaccc     3120

agcttaggga ccaaatgaga aggcctgaat tcaggggcag ggctctgtgg ggctcctttt     3180

ttgatctcta tggcaacaaa atgctaagac tttcttatgc taaaaatatg gataattgct     3240

gttaggtttt aatttgtcag ctctcagact tctaagccag tgatgttagc ctctggggtt     3300

gcttttaaca caaaatcatt taaatacttg aagcctgctt gagtcataaa aggccagtgg     3360

gactctagct cctaagtctg tttgctgctt ctgtaacaat agcacagact aatttgtaaa     3420

gaaaagaggt gtaggctggg tgcactggct cacgcctgta atcccagcac tttgggaggc     3480

cgaggtgggt ggatcacgag gtcagttcaa gaccagcctg gccaacatgg tgaaactctg     3540

tctctactag aaatacaaaa agtagctggg catggtggtg ggtgcctgta atcccagcta     3600

ctcaggaggc tgagacagga gaatcgcttg agcctgggag gcggaggttg cagtgagccg     3660

aggatgcacc actgcactcc agcctgggca acagagcgag cctccatctc aaaaaaacag     3720

aaaagtgtat ttctcacagt tctggaggct gggaatttca agagcatggt gcctgcatca     3780

ggtgggggtc atcccatgtc agaagggcac aaggtagaaa tgagtacatg agacaaaggg     3840

accatgggcc aaacttgctt tataacagcc ctctctcatg ataacctgct gtgtgatagt     3900

gacattaatc cactcatgag ggctctgtcc ttgtgactca gtcacctcgt attaagcccc     3960

atcttcaaca ctgttgcatt gggagtcaaa tttccaatgt gaacttttgg gggacacatt     4020

caaaccacag catttctgat tcttccaggc ctagatctca catgatgttg ctgttctcct     4080

ggttaccacc cccatccctt cccccatctt atcctagttt gctttctgga ccgggggaaa     4140

agggaaggag gatgcactat ttttaggtag aagctgctgg ctatgaccca gcacccctac     4200

agttattgat ttggcttcta atgtatcttg agaagtgcag tgggtaccgt ttttgttagt     4260

catcctgagg ccatgaactg ggtcttctca tggctggctt ggctccttca gactattata     4320

aatatccaca ggccttgcct ccctgccttc ctctgcttgg tttccttatg tttccatccc     4380

tagctacctt ggccttccta cactcggatc cttccacctc agttctttct tgttcttagt     4440

tcctcacata gcctcttgct gggagagaga caatgttgga agtaaggacg tatctaagac     4500

aatttccagt cttactccat ataaggtgat ggtatctagt gagtgacagt tgctgtccgt     4560

gtgtgactca gtgccttctt gttactcatc cctccatacg aggtggttag agtggagaga     4620

agcgggctgt gaacagactc tgggcccagc ttaaggtaaa agaaacttcc ctcaacatct     4680

acctgcacat ggtggctggt ggcgtagggg tgacattgtg atctagatcc tttgccagca     4740

tagttagaat ttccctacca gtcttcagtt ctagaaaaga ttctcacctg atttttgact     4800

tccagtctat gcttctgtat tcactaaggt ggcagcattt cctccctgtt ctttaaactg     4860

ctgtgctctt gacacaggaa ttctgcctgc ttcctcagac tcccaacaac ccccagatag     4920

gagttaccag tagaagcaga ggcttgacct gtgaactttt agtcctggag catatcatga     4980

agggaattga gtaaaaacct gaaggatgga attatatcac agtccctctt ttccgtgtaa     5040

tggaaaggct ttagtgaaaa tcaggcagca acacttggac agtgaaaaga gactctgaaa     5100

ggtgaggtga caggaggtgg cataatggtc attgttaaca tttatgcaag gttggttgta     5160

ggttaggtgt tctaatcgtg tattaagtca caaaatcctc acaacaatcc tctcaagtag     5220

tttattatct ttactttgta aacaaggaaa catatccaaa taagttaaat aattttcccc     5280

ataagcacaa agttagcaag ttagggattc caatccaagt actctcgctt cagatccctt     5340

gatcttaacc ttacctgcct ctcagcacca ccatggaaga caaggccttg gagtcagtga     5400

ggaagtgtca cttttcctat ccctgtaccc atagctctcc gtagactcag aatttttcca     5460

ctgccatgtc tttgcttatc ttgagtgaca gtgtttgtgg gtgaaccttg aaggtgctct     5520

ttctgctaca agggccctgg gagatagcat gggcatgtgc attgagaagc cagcctcaga     5580

ccttatcttg aagcagcttg aggccagacc tactgtaggc tcagcatctt gctaggaggc     5640

atgggagtga tctaacctgc cagctatctc tcttcctttc ctccttctgc tgatcaaagt     5700

cctgtccttt aagaccctga agctttccta ggtggagttg atctctcttt tcagtattct     5760

ttgtcctctt gtgggtcatc ttactctact tttatttagt aaataaaata attgcaataa     5820

aaattatttt attgaaaact ccattacttg atggttacag cctgatgagg ccagacttgg     5880

atgtctttct catgattgct ttgccttgca catattaaat gtctgtagaa ttgaatgaat     5940

gctgttcatt aaagtgttaa agtcagcacc aggctttcca aaggctgccc cttctaggct     6000

gcttttccca gcagcctcat ccattccttc ctcactccac caggagagaa gatgcagctt     6060

tactctttct gatgttacca tggtagcctg tgatactttc tttctaaagt gctgcttgcc     6120

atccaccaga gactgatgtt tccatggcaa ccaggtgaag gcaatagtca cgagctggat     6180

gcaggaaagg aattccggtc tgagaagctg catatctgaa tcttctagct tcagacatcc     6240

tttcccctct ctcataactt ttgcgcttta tatccaggac tggtttgctc tctggtgtgc     6300

ccttggttga gagagctctg tgaaagtgag gtgaagcaga ccaaccaact tagatcacgt     6360

gggaaggtgg gtgcaaggaa agagctgagc aaagatcact tcaaaaagtt ggatgaagtc     6420

tattagttgt tcagatgatc tgctctcaag agcccttaag gagttggctg gagtttctgg     6480

agagccatta agcagttatt tttgagagca atgggtagat ggatgaggtg cctgaagact     6540

ggaaagcagc cagtcagtgc cggattgtag aaaggagaaa caatgacctt ggaaatcgga     6600

gacccgtcaa acttgccaat gttccagaaa ggatgggagt ttcagtcagc tttcaggcat     6660

caggaagcct acttgcttag aattagtggt gctaagaatt cgcctcctca actcctgagc     6720

ataagcaagc taggggacct ccaccctgta gccgagtgtc acactctgga accacacagc     6780

atggttcaga tccctcttcc ctcacaaact agctgaataa gcttgggtag gttacttcac     6840

ttctctcaca cttcatctgt aaaaaggaaa tgataacacc tatctcatag ggatgttgtg     6900

agaattcatt gagaaaggtt tggaacttgg ctcattactg tcctcagtat tttcactcct     6960

ctggatgcct actcacttga ttttctagct gacttcattc tccccaactt tagagctcaa     7020

ggtttatggg gaaaagcaag ggcagtgcaa tggtgaaaat aaatcttcat ttttaaataa     7080

ataaattgtt cctgcactga agccccaagc ttacaaggtc ttgggtcaca cacaacctgc     7140

ctagttttca ggaaaacaga tcccactagc ccaatctctt tatgcttgag gctctgtcca     7200

catagttaga ttttaaccag atggtttcga aaaatcaaaa tgagcccccc tcacaggtac     7260

cttcaaggta cctaacacca ttagctttgt ctggcagggg aaaaatacca gggcactcag     7320

ttttgttttg ttttgagaca gggtctggct ctgttgccca tgctggagta cagtggtgcc     7380

atcacagctc actgcagtct caacctcctg agctcaaatg atcctcttga ttagctggaa     7440

ctacaggtat gtgccactat gcccagctaa gttttgtatt ttttgtagag atggggtctt     7500

gctatgttgc ccaggtggtc ttgaactcct gggcttaagt gatcctccct ccttagcctc     7560

ccaaagtgct aggattatag gtgtgagcca ccacaactgc ctgagagcac cctctgttac     7620

caccctttcc ttagcgtctc agcctccccc aagcacctgt ctttgttggt ctccagagcc     7680

tagccctaca ctggcatttt cctttctgaa taagtatttt ttttatttat ttatttttat     7740

tttttctttg agatggagtt tcgcttttgt tgcccaggct ggagtgcaat ggtgcgatct     7800

cggctcaccg caacctctgc ttcctgggtt caagtgattc tcctgcctca gcctcctgag     7860

tagctgggat tacaggcgtg cgccaccact cccagctaat tttgtatttt tagtggagac     7920

agggtttctc catgttggtc aggctggtct cgaactcctg acctcaggtg atccacccgc     7980

cttggcctcc caaagtgctg ggattacagt cctgagccac tgcactgggc cttatttatt     8040

tatttttaat taattaatta attttttttg agatggagtc ttgctttgtc gcccaggctg     8100

gagtgcagtg gcgcaatctc gggtcactgc aagctctgcc tcccaggttc atgccattct     8160

cctgcctcag cctcccaagt agctgggact acaggcacct gccactatgc ccggctaatt     8220

ttttgtattt tttagtagag atggggtttc actgttttag ccaggatggt ttcgatctcc     8280

tgacctagtg atccgctcgc ctcggcctcc cagagtgctg ggattacagg cgtgagccac     8340

tgcgcccggc tgggccttat ttatgtattt ttctgagaca gagtctcatg ctatcaccca     8400

ggctggagtg cagtggcatg atctctgctc actgcgatct ctgctcactt caacctctgc     8460

ttcccgggtt caagtgattc tcccacctca gcctcccgag tagctggaat tacaggcacc     8520

caccaccatg cctggctaat ttttgtaatt ttttttagta gaaatagggt ttcaccatgt     8580

tggccaggct ggtctctctc ttgacctcaa gtgatccacc cacctcggcc tcccaaagtg     8640

ctgggattac aggcgtgagc caattgcccg acctgagtaa gtattttaaa tcagcacagg     8700

tcctctgctt aaagtcaagt tgtaatttga acacaaaaat ggaaaatcat gcagtaaaat     8760

accatcgtgg agcttcaatt gccaatctgt cccccaacct tccatcagat gacaaaaccc     8820

aaaaaagtgt tacccgtgag tcctatggaa ggcacgttgg actttgtaga ccataactta     8880

aatttttatc tccaaatggt gctgtgcttt gagagtttag caagctgctt tgatgcctaa     8940

ataaagggcc aggacatagg ttgcaaaagg cattactact tccaccgctt ctctgtataa     9000

tgcttgagaa attacaaaga tctttgctct tttatttagt cctcatgact tcgctataag     9060

gtaggtattc ttcattttag agttgggata gcatagctga gttcagcaaa ccagacaggt     9120

taagagtgac ttcatccaca gacccccatc caggaaacat cctgagcact aattgaaaag     9180

cattcaaggg cttactgaat ttgcattcac atctggagtt ttcaaggcca ctaagctgtg     9240

gaaacttgac atcaatattc aaatagatga aaagggacct taagcatatc catcagggag     9300

tcaccgagat gataaaggcc tgagaagcag tatgctcttg tccggcattt gtgtcctttg     9360

acgactgcac catccaccca aattttgctg ccttctttat aggaagggcc ttttcctcat     9420

gtggtgggct gcccactgtt tcttctctgt gcatttgctc atgtagtttg accacaagga     9480

atgcttttcc ttctttctct caactatcta tagcctacat atcctttaag gcccagtttc     9540

taaaatatgt cttccaaatt tactgtttct tccattcaga attcctggag cacatgaggt     9600

agcccccagt tagatagaat gtggtattgt ttgctgctat tttgcctgtt ttgtgctgta     9660

tcacctcatc catctcccca gcttaattgc aagctatttg acgggcagaa attgtgtctt     9720

atttgtattt gttttcccca ttgggcccgg cacactgatt ggcatattgc agatgtttag     9780

tacttgagag aaacaaaatg tcttctagca tttgtggatg aaagattaaa atgtccagga     9840

aaatttactt agattgatgt ggattgaaac tatattagat taataaaaag atgtgtgtgt     9900

gtgaa                                                                 9905


<210>  11
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Glu Ala Leu Glu Gln Leu Asn Gly 
    50                  55                  60                  


Phe Glu Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  12
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Lys Ala Leu Glu Tyr Leu Asn Gly 
    50                  55                  60                  


Phe Glu Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  13
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Lys Ala Leu Glu Gln Leu Asn Gly 
    50                  55                  60                  


Phe Lys Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  14
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Glu Ala Leu Glu Tyr Leu Asn Gly 
    50                  55                  60                  


Phe Glu Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  15
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  15

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Glu Ala Leu Glu Gln Leu Asn Gly 
    50                  55                  60                  


Phe Lys Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  16
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Lys Ala Leu Glu Tyr Leu Asn Gly 
    50                  55                  60                  


Phe Lys Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  17
<211>  83
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Glu Ala Leu Glu Tyr Leu Asn Gly 
    50                  55                  60                  


Phe Lys Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu Arg 
65                  70                  75                  80  


Thr Asp Ala 
            


<210>  18
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Arg Ile Glu Ser Ile Gln Leu 
            20                  25                  30          


Met Met Asp Ser Glu Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Lys Lys Ala Leu Glu Gln Leu Asn Gly 
    50                  55                  60                  


Phe Glu Leu Ala Gly Arg Pro Met Lys Val Gly His Val Thr Glu 
65                  70                  75                  


<210>  19
<211>  79
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Met Arg Leu Tyr Val Gly Ser Leu His Phe Asn Ile Thr Glu Asp Met 
1               5                   10                  15      


Leu Arg Gly Ile Phe Glu Pro Phe Gly Lys Ile Asp Asn Ile Val Leu 
            20                  25                  30          


Met Lys Asp Ser Asp Thr Gly Arg Ser Lys Gly Tyr Gly Phe Ile Thr 
        35                  40                  45              


Phe Ser Asp Ser Glu Cys Ala Arg Arg Ala Leu Glu Gln Leu Asn Gly 
    50                  55                  60                  


Phe Glu Leu Ala Gly Arg Pro Met Arg Val Gly His Val Thr Glu 
65                  70                  75                  


<210>  20
<211>  26
<212>  PRT
<213>  Homo sapiens

<400>  20

His Gly Phe Met Leu His Thr Lys Tyr Gln Val Val Tyr Pro Phe Pro 
1               5                   10                  15      


Thr Phe Gln Pro Ala Phe Gln Leu Lys Lys 
            20                  25      


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Trp Leu Val Pro Glu Ser Ser Gly Arg 
1               5