                         SEQUENCE LISTING

<110>  Biomarin Pharmaceutical Inc.
 
<120>  CNP VARIANTS AND CONJUGATES THEREOF

<130>  30610/54736

<150>  US 62/901,093
<151>  2019-09-16

<150>  US 62/935,050
<151>  2019-11-13

<150>  US 62/963,350
<151>  2020-01-20

<150>  US 62/964,852
<151>  2020-01-23

<150>  US 62/038,667
<151>  2020-06-12

<160>  68    

<170>  PatentIn version 3.5

<210>  1
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  1

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  2
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  2

Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  3
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  3

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  4
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  4

Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
1               5                   10                  15      


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
            20                  25                  30          


Gly Cys 
        


<210>  5
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  5

Pro Gly Gln Glu His Pro Gln Ala Arg Arg Tyr Arg Gly Ala Gln Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  6
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  6

Pro Gly Gln Glu His Pro Asn Ala Arg Arg Tyr Arg Gly Ala Asn Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  7
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  7

Pro Gly Gln Glu His Pro Gln Ala Arg Lys Tyr Lys Gly Ala Gln Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  8
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal OH

<400>  8

Pro Gly Gln Glu His Pro Gln Ala Arg Arg Tyr Arg Gly Ala Gln Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  9
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal NH2

<400>  9

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  10
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal OH

<400>  10

Pro Gly Gln Glu His Pro Asn Ala Arg Arg Tyr Arg Gly Ala Asn Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  11
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal NH2

<400>  11

Pro Gly Gln Glu His Pro Asn Ala Arg Arg Tyr Arg Gly Ala Asn Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  12
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal NH2

<400>  12

Pro Gly Gln Glu His Pro Gln Ala Arg Arg Tyr Arg Gly Ala Gln Arg 
1               5                   10                  15      


Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  13
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal NH2

<400>  13

Pro Gly Gln Glu His Pro Gln Ala Arg Lys Tyr Lys Gly Ala Gln Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  14
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N -terminal Acetyl

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C -terminal OH

<400>  14

Pro Gly Gln Glu His Pro Gln Ala Arg Lys Tyr Lys Gly Ala Gln Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  15
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  15

Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
1               5                   10                  15      


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
            20                  25                  30          


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
        35                  40                  45              


Gly Leu Gly Cys 
    50          


<210>  16
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  16

Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  17
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  17

Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His 
1               5                   10                  15      


Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            20                  25                  30          


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        35                  40                  45              


Gly Cys 
    50  


<210>  18
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  18

Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro 
1               5                   10                  15      


Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
            20                  25                  30          


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
        35                  40                  45              


Cys 
    


<210>  19
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  19

Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  20
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  20

Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
            20                  25                  30          


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45          


<210>  21
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  21

Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
1               5                   10                  15      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            20                  25                  30          


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45      


<210>  22
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  22

Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  23
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  23

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
            20                  25                  30          


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  


<210>  24
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  24

Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  25
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  25

Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  26
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  26

Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala 
1               5                   10                  15      


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
            20                  25                  30          


Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40      


<210>  27
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  27

Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
1               5                   10                  15      


Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
            20                  25                  30          


Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40  


<210>  28
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  28

Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  29
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  29

Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  30
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  30

His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  31
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  31

Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
1               5                   10                  15      


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30          


Cys 
    


<210>  32
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  32

Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
1               5                   10                  15      


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30          


<210>  33
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  33

Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
1               5                   10                  15      


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30      


<210>  34
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  34

Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
1               5                   10                  15      


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  35

Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
1               5                   10                  15      


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  


<210>  36
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  36

Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  37
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  37

Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  38
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  38

Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25      


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  39

Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
1               5                   10                  15      


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25  


<210>  40
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  40

Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  41
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  41

Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  42
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  42

Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
1               5                   10                  15      


Ser Gly Leu Gly Cys 
            20      


<210>  43
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  43

Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
1               5                   10                  15      


Gly Leu Gly Cys 
            20  


<210>  44
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  44

Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
1               5                   10                  15      


Leu Gly Cys 
            


<210>  45
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  45

Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  46
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  46

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asn 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  47
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  47

Met Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  48
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  48

Pro Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  49
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  49

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Asn Ser Gly Leu Gly Cys 
        35              


<210>  50
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  50

Met Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  51
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  51

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  52
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  52

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Pro Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  53
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  53

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  54
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  54

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Gln 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  55
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  55

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Pro 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  56
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  56

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  57
<211>  667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  57
atggcactgc catccctgct actggtggtg gcagccctgg caggtggggt gcgtcctccg       60

ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg      120

gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcgctggg ccgggcactg      180

cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga gtacctggca      240

ccactgcgcg ctgtggatct caagctgtac catgaccccg accttctgtt gggccctggt      300

tgtgtgtacc ctgctgcctc tgtggctcgc tttgcctcgc actggcacct tcccctcctg      360

actgcgggtg cagtggcctc tggctttgca gctaagaatg agcattatcg taccctggtt      420

cgcactggcc cctctgcgcc caagctgggt gagttcgtag tgacattaca cgggcacttc      480

aattggactg ctcgggctgc tttgctgtat ctggatgctc gcacagatga ccggccccac      540

tacttcacca tcgagggggt gtttgaggcc ctgcagggca gcaacctcag tgtgcaacac      600

caggtgtata cccgagagcc aggtggccct gagcaagcca cccacttcat cagagccaac      660

gggcgca                                                                667


<210>  58
<211>  667
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  58
atggcactgc catccctgct actggtggtg gcagccctgg caggtggggt gcgtcctccg       60

ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg      120

gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcgctggg ccgggcactg      180

cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga gtacctggca      240

ccactgcgcg ctgtggatct caagctgtac catgaccccg accttctgtt gggccctggt      300

tgtgtgtacc ctgctgcctc tgtggctcgc tttgcctcgc actggcacct tcccctcctg      360

actgcgggtg cagtggcctc tggctttgca gctaagaatg agcattatcg taccctggtt      420

cgcactggcc cctctgcgcc caagctgggt gagttcgtag tgacattaca cgggcacttc      480

aattggactg ctcgggctgc tttgctgtat ctggatgctc gcacagatga ccggccccac      540

tacttcacca tcgagggggt gtttgaggcc ctgcagggca gcaacctcag tgtgcaacac      600

caggtgtata cccgagagcc aggtggccct gagcaagcca cccacttcat cagagccaac      660

gggcgca                                                                667


<210>  59
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  59
atggcactgc catccctgct actggtggtg gcagccctgg caggtggggt gcgtcctccg       60

ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg      120

gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcgctggg ccgggcactg      180

cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga gtacctggca      240

ccactgcgcg ctgtggatct caagctgtac catgaccccg accttctgtt gggccctggt      300

tgtgtgtacc ctgctgcctc tgtggctcgc tttgcctcgc actggcacct tcccctcctg      360

actgcgggtg cagtggcctc tggctttgca gctaagaatg agcattatcg taccctggtt      420

cgcactggcc cctctgcgcc caagctgggt gagttcgtag tgacattaca cgggcacttc      480

acaattggac tgctcgggct gctttgctgt atctggatgc tcgcacagat gaccggcccc      540

actacttcac catcgagggg gtgtttgagg ccctgcaggg cagcaacctc agtgtgcaac      600

accaggtgta tacccgagag ccaggtggcc ctgagcaagc cacccacttc atcagagcca      660

acgggcgca                                                              669


<210>  60
<211>  668
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  60
atggcactgc catccctgct actggtggtg gcagccctgg caggtggggt gcgtcctccg       60

ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg      120

gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcgctggg ccgggcactg      180

cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga gtacctggca      240

ccactgcgcg ctgtggatct caagctgtac catgaccccg accttctgtt gggccctggt      300

tgtgtgtacc ctgctgcctc tgtggctcgc tttgcctcgc actggcacct tcccctcctg      360

actgcgggtg cagtggcctc tggctttgca gctaagaatg agcattatcg taccctggtt      420

cgcactggcc cctctgcgcc caagctgggt gagttcgtag tgacattaca cgggcacttc      480

aattggactg ctcgggctgc tttgctgtat ctggatgctc gcacagatga ccggccccac      540

tacttcacca tccgaggggg tgtttgaggc cctgcagggc agcaacctca gtgtgcaaca      600

ccaggtgtat acccgagagc caggtggccc tgagcaagcc acccacttca tcagagccaa      660

cgggcgca                                                               668


<210>  61
<211>  354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Polynucleotide

<400>  61
atggcactgc catccctgct actggtggtg gcagccctgg caggtggggt gcgtcctccg       60

ggggcacgga acctgacgct ggcggtggtg ctgccagaac acaacctgag ctatgcctgg      120

gcctggccac gggtgggtcc tgctgtggca ctggctgtgg aggcgctggg ccgggcactg      180

cccgtggacc tgcggtttgt cagctccgaa ctagacggcg cctgctctga gtacctggca      240

ccggggtgtt tgaggccctg cagggcagca acctcagtgt gcaacaccag gtgtataccc      300

gagagccagg tggccctgag caagccaccc acttcatcag agccaacggg cgca            354


<210>  62
<211>  1047
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  62

Met Ala Leu Pro Ser Leu Leu Leu Val Val Ala Ala Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
            20                  25                  30          


Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
        35                  40                  45              


Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
    50                  55                  60                  


Arg Phe Val Ser Ser Glu Leu Asp Gly Ala Cys Ser Glu Tyr Leu Ala 
65                  70                  75                  80  


Pro Leu Arg Ala Val Asp Leu Lys Leu Tyr His Asp Pro Asp Leu Leu 
                85                  90                  95      


Leu Gly Pro Gly Cys Val Tyr Pro Ala Ala Ser Val Ala Arg Phe Ala 
            100                 105                 110         


Ser His Trp His Leu Pro Leu Leu Thr Ala Gly Ala Val Ala Ser Gly 
        115                 120                 125             


Phe Ala Ala Lys Asn Glu His Tyr Arg Thr Leu Val Arg Thr Gly Pro 
    130                 135                 140                 


Ser Ala Pro Lys Leu Gly Glu Phe Val Val Thr Leu His Gly His Phe 
145                 150                 155                 160 


Asn Trp Thr Ala Arg Ala Ala Leu Leu Tyr Leu Asp Ala Arg Thr Asp 
                165                 170                 175     


Asp Arg Pro His Tyr Phe Thr Ile Glu Gly Val Phe Glu Ala Leu Gln 
            180                 185                 190         


Gly Ser Asn Leu Ser Val Gln His Gln Val Tyr Thr Arg Glu Pro Gly 
        195                 200                 205             


Gly Pro Glu Gln Ala Thr His Phe Ile Arg Ala Asn Gly Arg Ile Val 
    210                 215                 220                 


Tyr Ile Cys Gly Pro Leu Glu Met Leu His Glu Ile Leu Leu Gln Ala 
225                 230                 235                 240 


Gln Arg Glu Asn Leu Thr Asn Gly Asp Tyr Val Phe Phe Tyr Leu Asp 
                245                 250                 255     


Val Phe Gly Glu Ser Leu Arg Ala Gly Pro Thr Arg Ala Thr Gly Arg 
            260                 265                 270         


Pro Trp Gln Asp Asn Arg Thr Gln Glu Gln Ala Gln Ala Leu Arg Glu 
        275                 280                 285             


Ala Phe Gln Thr Val Leu Val Ile Thr Tyr Arg Glu Pro Pro Asn Pro 
    290                 295                 300                 


Glu Tyr Gln Glu Phe Gln Asn Arg Leu Leu Ile Arg Ala Arg Glu Asp 
305                 310                 315                 320 


Phe Gly Val Glu Leu Ala Pro Ser Leu Met Asn Leu Ile Ala Gly Cys 
                325                 330                 335     


Phe Tyr Asp Gly Ile Leu Leu Tyr Ala Gln Val Leu Asn Glu Thr Ile 
            340                 345                 350         


Gln Glu Gly Gly Thr Arg Glu Asp Gly Leu Arg Ile Val Glu Lys Met 
        355                 360                 365             


Gln Gly Arg Arg Tyr His Gly Val Thr Gly Leu Val Val Met Asp Lys 
    370                 375                 380                 


Asn Asn Asp Arg Glu Thr Asp Phe Val Leu Trp Ala Met Gly Asp Leu 
385                 390                 395                 400 


Glu Ser Gly Asp Phe Gln Pro Ala Ala His Tyr Ser Gly Ala Glu Lys 
                405                 410                 415     


Gln Ile Trp Trp Thr Gly Arg Pro Ile Pro Trp Val Lys Gly Ala Pro 
            420                 425                 430         


Pro Leu Asp Asn Pro Pro Cys Ala Phe Asp Leu Asp Asp Pro Ser Cys 
        435                 440                 445             


Asp Lys Thr Pro Leu Ser Thr Leu Ala Ile Val Ala Leu Gly Thr Gly 
    450                 455                 460                 


Ile Thr Phe Ile Met Phe Gly Val Ser Ser Phe Leu Ile Phe Arg Lys 
465                 470                 475                 480 


Leu Met Leu Glu Lys Glu Leu Ala Ser Met Leu Trp Arg Ile Arg Trp 
                485                 490                 495     


Glu Glu Leu Gln Phe Gly Asn Ser Asp Arg Tyr His Lys Gly Ala Gly 
            500                 505                 510         


Ser Arg Leu Thr Leu Ser Leu Arg Gly Ser Ser Tyr Gly Ser Leu Met 
        515                 520                 525             


Thr Ala His Gly Lys Tyr Gln Ile Phe Ala Asn Thr Gly His Phe Lys 
    530                 535                 540                 


Gly Asn Val Val Ala Ile Lys His Val Asn Lys Lys Arg Ile Glu Leu 
545                 550                 555                 560 


Thr Arg Gln Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Phe 
                565                 570                 575     


Asn His Leu Thr Arg Phe Ile Gly Ala Cys Ile Asp Pro Pro Asn Ile 
            580                 585                 590         


Cys Ile Val Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
        595                 600                 605             


Glu Asn Asp Ser Ile Asn Leu Asp Trp Met Phe Arg Tyr Ser Leu Ile 
    610                 615                 620                 


Asn Asp Leu Val Lys Gly Met Ala Phe Leu His Asn Ser Ile Ile Ser 
625                 630                 635                 640 


Ser His Gly Ser Leu Lys Ser Ser Asn Cys Val Val Asp Ser Arg Phe 
                645                 650                 655     


Val Leu Lys Ile Thr Asp Tyr Gly Leu Ala Ser Phe Arg Ser Thr Ala 
            660                 665                 670         


Glu Pro Asp Asp Ser His Ala Leu Tyr Ala Lys Lys Leu Trp Thr Ala 
        675                 680                 685             


Pro Glu Leu Leu Ser Gly Asn Pro Leu Pro Thr Thr Gly Met Gln Lys 
    690                 695                 700                 


Ala Asp Val Tyr Ser Phe Ala Ile Ile Leu Gln Glu Ile Ala Leu Arg 
705                 710                 715                 720 


Ser Gly Pro Phe Tyr Leu Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile 
                725                 730                 735     


Val Gln Lys Val Arg Asn Gly Gln Arg Pro Tyr Phe Arg Pro Ser Ile 
            740                 745                 750         


Asp Arg Thr Gln Leu Asn Glu Glu Leu Val Leu Leu Met Glu Arg Cys 
        755                 760                 765             


Trp Ala Gln Asp Pro Thr Glu Arg Pro Asp Phe Gly Gln Ile Lys Gly 
    770                 775                 780                 


Phe Ile Arg Arg Phe Asn Lys Glu Gly Gly Thr Ser Ile Leu Asp Asn 
785                 790                 795                 800 


Leu Leu Leu Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Lys Leu Val 
                805                 810                 815     


Glu Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala 
            820                 825                 830         


Leu Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg 
        835                 840                 845             


Gly Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe 
    850                 855                 860                 


Ser Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met 
865                 870                 875                 880 


Gln Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Ile 
                885                 890                 895     


Ile Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr 
            900                 905                 910         


Met Val Val Ser Gly Leu Pro Gly Arg Asn Gly Gln Arg His Ala Pro 
        915                 920                 925             


Glu Ile Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Ser Ser Phe 
    930                 935                 940                 


Arg Ile Arg His Arg Pro His Asp Gln Leu Arg Leu Arg Ile Gly Val 
945                 950                 955                 960 


His Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg 
                965                 970                 975     


Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser 
            980                 985                 990         


Asn Gly Gln Ala Leu Lys Ile His  Val Ser Ser Thr Thr  Lys Asp Ala 
        995                 1000                 1005             


Leu Asp  Glu Leu Gly Cys Phe  Gln Leu Glu Leu Arg  Gly Asp Val 
    1010                 1015                 1020             


Glu Met  Lys Gly Lys Gly Lys  Met Arg Thr Tyr Trp  Leu Leu Gly 
    1025                 1030                 1035             


Glu Arg  Lys Gly Pro Pro Gly  Leu Leu 
    1040                 1045         


<210>  63
<211>  1047
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  63

Met Ala Leu Pro Ser Leu Leu Leu Val Val Ala Ala Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
            20                  25                  30          


Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
        35                  40                  45              


Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
    50                  55                  60                  


Arg Phe Val Ser Ser Glu Leu Asp Gly Ala Cys Ser Glu Tyr Leu Ala 
65                  70                  75                  80  


Pro Leu Arg Ala Val Asp Leu Lys Leu Tyr His Asp Pro Asp Leu Leu 
                85                  90                  95      


Leu Gly Pro Gly Cys Val Tyr Pro Ala Ala Ser Val Ala Arg Phe Ala 
            100                 105                 110         


Ser His Trp His Leu Pro Leu Leu Thr Ala Gly Ala Val Ala Ser Gly 
        115                 120                 125             


Phe Ala Ala Lys Asn Glu His Tyr Arg Thr Leu Val Arg Thr Gly Pro 
    130                 135                 140                 


Ser Ala Pro Lys Leu Gly Glu Phe Val Val Thr Leu His Gly His Phe 
145                 150                 155                 160 


Asn Trp Thr Ala Arg Ala Ala Leu Leu Tyr Leu Asp Ala Arg Thr Asp 
                165                 170                 175     


Asp Arg Pro His Tyr Phe Thr Ile Glu Gly Val Phe Glu Ala Leu Gln 
            180                 185                 190         


Gly Ser Asn Leu Ser Val Gln His Gln Val Tyr Thr Arg Glu Pro Gly 
        195                 200                 205             


Gly Pro Glu Gln Ala Thr His Phe Ile Arg Ala Asn Gly Arg Ile Val 
    210                 215                 220                 


Tyr Ile Cys Gly Pro Leu Glu Met Leu His Glu Ile Leu Leu Gln Ala 
225                 230                 235                 240 


Gln Arg Glu Asn Leu Thr Asn Gly Asp Tyr Val Phe Phe Tyr Leu Asp 
                245                 250                 255     


Val Phe Gly Glu Ser Leu Arg Ala Gly Pro Thr Arg Ala Thr Gly Arg 
            260                 265                 270         


Pro Trp Gln Asp Asn Arg Thr Gln Glu Gln Ala Gln Ala Leu Arg Glu 
        275                 280                 285             


Ala Phe Gln Thr Val Leu Val Ile Thr Tyr Arg Glu Pro Pro Asn Pro 
    290                 295                 300                 


Glu Tyr Gln Glu Phe Gln Asn Arg Leu Leu Ile Arg Ala Arg Glu Asp 
305                 310                 315                 320 


Phe Gly Val Glu Leu Ala Pro Ser Leu Met Asn Leu Ile Ala Gly Cys 
                325                 330                 335     


Phe Tyr Asp Gly Ile Leu Leu Tyr Ala Gln Val Leu Asn Glu Thr Ile 
            340                 345                 350         


Gln Glu Gly Gly Thr Arg Glu Asp Gly Leu Arg Ile Val Glu Lys Met 
        355                 360                 365             


Gln Gly Arg Arg Tyr His Gly Val Thr Gly Leu Val Val Met Asp Lys 
    370                 375                 380                 


Asn Asn Asp Arg Glu Thr Asp Phe Val Leu Trp Ala Met Gly Asp Leu 
385                 390                 395                 400 


Glu Ser Gly Asp Phe Gln Pro Ala Ala His Tyr Ser Gly Ala Glu Lys 
                405                 410                 415     


Gln Ile Trp Trp Thr Gly Arg Pro Ile Pro Trp Val Lys Gly Ala Pro 
            420                 425                 430         


Pro Leu Asp Asn Pro Pro Cys Ala Phe Asp Leu Asp Asp Pro Ser Cys 
        435                 440                 445             


Asp Lys Thr Pro Leu Ser Thr Leu Ala Ile Val Ala Leu Gly Thr Gly 
    450                 455                 460                 


Ile Thr Phe Ile Met Phe Gly Val Ser Ser Phe Leu Ile Phe Arg Lys 
465                 470                 475                 480 


Leu Met Leu Glu Lys Glu Leu Ala Ser Met Leu Trp Arg Ile Arg Trp 
                485                 490                 495     


Glu Glu Leu Gln Phe Gly Asn Ser Asp Arg Tyr His Lys Gly Ala Gly 
            500                 505                 510         


Ser Arg Leu Thr Leu Ser Leu Arg Gly Ser Ser Tyr Gly Ser Leu Met 
        515                 520                 525             


Thr Ala His Gly Lys Tyr Gln Ile Phe Ala Asn Thr Gly His Phe Lys 
    530                 535                 540                 


Gly Asn Val Val Ala Ile Lys His Val Asn Lys Lys Arg Ile Glu Leu 
545                 550                 555                 560 


Thr Arg Gln Val Leu Phe Glu Leu Lys His Met Arg Asp Val Gln Phe 
                565                 570                 575     


Asn His Leu Thr Arg Phe Ile Gly Ala Cys Ile Asp Pro Pro Asn Ile 
            580                 585                 590         


Cys Ile Val Thr Glu Tyr Cys Pro Arg Gly Ser Leu Gln Asp Ile Leu 
        595                 600                 605             


Glu Asn Asp Ser Ile Asn Leu Asp Trp Met Phe Arg Tyr Ser Leu Ile 
    610                 615                 620                 


Asn Asp Leu Val Lys Gly Met Ala Phe Leu His Asn Ser Ile Ile Ser 
625                 630                 635                 640 


Ser His Gly Ser Leu Lys Ser Ser Asn Cys Val Val Asp Ser Arg Phe 
                645                 650                 655     


Val Leu Lys Ile Thr Asp Tyr Gly Leu Ala Ser Phe Arg Ser Thr Ala 
            660                 665                 670         


Glu Pro Asp Asp Ser His Ala Leu Tyr Ala Lys Lys Leu Trp Thr Ala 
        675                 680                 685             


Pro Glu Leu Leu Ser Gly Asn Pro Leu Pro Thr Thr Gly Met Gln Lys 
    690                 695                 700                 


Ala Asp Val Tyr Ser Phe Ala Ile Ile Leu Gln Glu Ile Ala Leu Arg 
705                 710                 715                 720 


Ser Gly Pro Phe Tyr Leu Glu Gly Leu Asp Leu Ser Pro Lys Glu Ile 
                725                 730                 735     


Val Gln Lys Val Arg Asn Gly Gln Arg Pro Tyr Phe Arg Pro Ser Ile 
            740                 745                 750         


Asp Arg Thr Gln Leu Asn Glu Glu Leu Val Leu Leu Met Glu Arg Cys 
        755                 760                 765             


Trp Ala Gln Asp Pro Thr Glu Arg Pro Asp Phe Gly Gln Ile Lys Gly 
    770                 775                 780                 


Phe Ile Arg Arg Phe Asn Lys Glu Gly Gly Thr Ser Ile Leu Asp Asn 
785                 790                 795                 800 


Leu Leu Leu Arg Met Glu Gln Tyr Ala Asn Asn Leu Glu Lys Leu Val 
                805                 810                 815     


Glu Glu Arg Thr Gln Ala Tyr Leu Glu Glu Lys Arg Lys Ala Glu Ala 
            820                 825                 830         


Leu Leu Tyr Gln Ile Leu Pro His Ser Val Ala Glu Gln Leu Lys Arg 
        835                 840                 845             


Gly Glu Thr Val Gln Ala Glu Ala Phe Asp Ser Val Thr Ile Tyr Phe 
    850                 855                 860                 


Ser Asp Ile Val Gly Phe Thr Ala Leu Ser Ala Glu Ser Thr Pro Met 
865                 870                 875                 880 


Gln Val Val Thr Leu Leu Asn Asp Leu Tyr Thr Cys Phe Asp Ala Ile 
                885                 890                 895     


Ile Asp Asn Phe Asp Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr 
            900                 905                 910         


Met Val Val Ser Gly Leu Pro Gly Arg Asn Gly Gln Arg His Ala Pro 
        915                 920                 925             


Glu Ile Ala Arg Met Ala Leu Ala Leu Leu Asp Ala Val Ser Ser Phe 
    930                 935                 940                 


Arg Ile Arg His Arg Pro His Asp Gln Leu Arg Leu Arg Ile Gly Val 
945                 950                 955                 960 


His Thr Gly Pro Val Cys Ala Gly Val Val Gly Leu Lys Met Pro Arg 
                965                 970                 975     


Tyr Cys Leu Phe Gly Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser 
            980                 985                 990         


Asn Gly Gln Ala Leu Lys Ile His  Val Ser Ser Thr Thr  Lys Asp Ala 
        995                 1000                 1005             


Leu Asp  Glu Leu Gly Cys Phe  Gln Leu Glu Leu Arg  Gly Asp Val 
    1010                 1015                 1020             


Glu Met  Lys Gly Lys Gly Lys  Met Arg Thr Tyr Trp  Leu Leu Gly 
    1025                 1030                 1035             


Glu Arg  Lys Gly Pro Pro Gly  Leu Leu 
    1040                 1045         


<210>  64
<211>  245
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  64

Met Ala Leu Pro Ser Leu Leu Leu Val Val Ala Ala Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
            20                  25                  30          


Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
        35                  40                  45              


Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
    50                  55                  60                  


Arg Phe Val Ser Ser Glu Leu Asp Gly Ala Cys Ser Glu Tyr Leu Ala 
65                  70                  75                  80  


Pro Leu Arg Ala Val Asp Leu Lys Leu Tyr His Asp Pro Asp Leu Leu 
                85                  90                  95      


Leu Gly Pro Gly Cys Val Tyr Pro Ala Ala Ser Val Ala Arg Phe Ala 
            100                 105                 110         


Ser His Trp His Leu Pro Leu Leu Thr Ala Gly Ala Val Ala Ser Gly 
        115                 120                 125             


Phe Ala Ala Lys Asn Glu His Tyr Arg Thr Leu Val Arg Thr Gly Pro 
    130                 135                 140                 


Ser Ala Pro Lys Leu Gly Glu Phe Val Val Thr Leu His Gly His Phe 
145                 150                 155                 160 


Thr Ile Gly Leu Leu Gly Leu Leu Cys Cys Ile Trp Met Leu Ala Gln 
                165                 170                 175     


Met Thr Gly Pro Thr Thr Ser Pro Ser Arg Gly Cys Leu Arg Pro Cys 
            180                 185                 190         


Arg Ala Ala Thr Ser Val Cys Asn Thr Arg Cys Ile Pro Glu Ser Gln 
        195                 200                 205             


Val Ala Leu Ser Lys Pro Pro Thr Ser Ser Glu Pro Thr Gly Ala Leu 
    210                 215                 220                 


Cys Ile Ser Ala Ala Arg Trp Arg Cys Phe Met Arg Ser Cys Phe Arg 
225                 230                 235                 240 


Pro Arg Gly Arg Thr 
                245 


<210>  65
<211>  188
<212>  PRT
<213>  Artificial Seuqence

<220>
<223>  Synthetic Polypeptide

<400>  65

Met Ala Leu Pro Ser Leu Leu Leu Val Val Ala Ala Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
            20                  25                  30          


Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
        35                  40                  45              


Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
    50                  55                  60                  


Arg Phe Val Ser Ser Glu Leu Asp Gly Ala Cys Ser Glu Tyr Leu Ala 
65                  70                  75                  80  


Pro Leu Arg Ala Val Asp Leu Lys Leu Tyr His Asp Pro Asp Leu Leu 
                85                  90                  95      


Leu Gly Pro Gly Cys Val Tyr Pro Ala Ala Ser Val Ala Arg Phe Ala 
            100                 105                 110         


Ser His Trp His Leu Pro Leu Leu Thr Ala Gly Ala Val Ala Ser Gly 
        115                 120                 125             


Phe Ala Ala Lys Asn Glu His Tyr Arg Thr Leu Val Arg Thr Gly Pro 
    130                 135                 140                 


Ser Ala Pro Lys Leu Gly Glu Phe Val Val Thr Leu His Gly His Phe 
145                 150                 155                 160 


Asn Trp Thr Ala Arg Ala Ala Leu Leu Tyr Leu Asp Ala Arg Thr Asp 
                165                 170                 175     


Asp Arg Pro His Tyr Phe Thr Ile Arg Gly Gly Val 
            180                 185             


<210>  66
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  66

Met Ala Leu Pro Ser Leu Leu Leu Val Val Ala Ala Leu Ala Gly Gly 
1               5                   10                  15      


Val Arg Pro Pro Gly Ala Arg Asn Leu Thr Leu Ala Val Val Leu Pro 
            20                  25                  30          


Glu His Asn Leu Ser Tyr Ala Trp Ala Trp Pro Arg Val Gly Pro Ala 
        35                  40                  45              


Val Ala Leu Ala Val Glu Ala Leu Gly Arg Ala Leu Pro Val Asp Leu 
    50                  55                  60                  


Arg Phe Val Ser Ser Glu Leu Asp Gly Ala Cys Ser Glu Tyr Leu Ala 
65                  70                  75                  80  


Pro Gly Cys Leu Arg Pro Cys Arg Ala Ala Thr Ser Val Cys Asn Thr 
                85                  90                  95      


Arg Cys Ile Pro Glu Ser Gln Val Ala Leu Ser Lys Pro Pro Thr Ser 
            100                 105                 110         


Ser Glu Pro Thr Gly Ala Leu Cys Ile Ser Ala Ala Arg Trp Arg Cys 
        115                 120                 125             


Phe Met Arg Ser Cys Phe Arg Pro Arg Gly Arg Thr 
    130                 135                 140 


<210>  67
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  67

Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
1               5                   10                  15      


Cys 
    


<210>  68
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide

<400>  68

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


