                         SEQUENCE LISTING

<110>  Darvish, Daniel
 
<120>  GNE AS A THERAPEUTIC AGENT

<130>  H002

<140>  US 16/574,644
<141>  2019-09-18

<150>  US 62/732,931
<151>  2018-09-18

<160>  19    

<170>  PatentIn version 3.5

<210>  1
<211>  3838
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2301)..(2303)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2310)..(2312)
<223>  n is a, c, g, or t

<400>  1
ccgcctaatg agcgggcttt tttttggctt gttgtccaca accgttaaac cttaaaagct       60

ttaaaagcct tatatattct tttttttctt ataaaactta aaaccttaga ggctatttaa      120

gttgctgatt tatattaatt ttattgttca aacatgagag cttagtacgt gaaacatgag      180

agcttagtac gttagccatg agagcttagt acgttagcca tgagggttta gttcgttaaa      240

catgagagct tagtacgtta aacatgagag cttagtacgt actatcaaca ggttgaactg      300

ctgatccacg ttgtggtaga attggtaaag agagtcgtgt aaaatatcga gttcgcacat      360

cttgttgtct gattattgat ttttggcgaa accatttgat catatgacaa gatgtgtatc      420

taccttaact taatgatttt gataaaaatc attaggtacc ccggctctag ttattaatag      480

taatcaatta cggggtcatt agttcatagc ccatatatgg agttccgcgt tacataactt      540

acggtaaatg gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg      600

acgtatgttc ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat      660

ttacggtaaa ctgcccactt ggcagtacat caagtgtatc atatgccaag tacgccccct      720

attgacgtca atgacggtaa atggcccgcc tggcattatg cccagtacat gaccttatgg      780

gactttccta cttggcagta catctacgta ttagtcatcg ctattaccat ggtgatgcgg      840

ttttggcagt acatcaatgg gcgtggatag cggtttgact cacggggatt tccaagtctc      900

caccccattg acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa      960

tgtcgtaaca actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc     1020

tatataagca gagctcgttt agtgaaccgt cagatcgcct ggagacgcca tccacgctgt     1080

tttgacctcc atagaagaca ccgggaccga tccagcctcc gcggctcgca tctctccttc     1140

acgcgcccgc cgccctacct gaggccgcca tccacgccgg ttgagtcgcg ttctgccgcc     1200

tcccgcctgt ggtgcctcct gaactgcgtc cgccgtctag gtaagtttaa agctcaggtc     1260

gagaccgggc ctttgtccgg cgctcccttg gagcctacct agactcagcc ggctctccac     1320

gctttgcctg accctgcttg ctcaactcta gttctctcgt taacttaatg agacagatag     1380

aaactggtct tgtagaaaca gagtagtcgc ctgcttttct gccaggtgct gacttctctc     1440

ccctgggctt ttttcttttt ctcaggttga aaagaagaag acgaagaaga cgaagaagac     1500

aaaccgtcgt cgacatggag aagaatggaa ataaccgaaa gctgcgggtt tgtgttgcta     1560

cttgtaaccg tgcagattat tctaaacttg ccccgatcat gtttggcatt aaaaccgaac     1620

ctgagttctt tgaacttgat gttgtggtac ttggctctca cctgatagat gactatggaa     1680

atacatatcg aatgattgaa caagatgact ttgacattaa caccaggcta cacacaattg     1740

tgaggggaga agatgaggca gccatggtgg agtcagtagg cctggcccta gtgaagctgc     1800

cagatgtcct taatcgcctg aagcctgata tcatgattgt tcatggagac aggtttgatg     1860

ccctggctct ggccacatct gctgccttga tgaacatccg aatccttcac attgaaggtg     1920

gggaagtcag tgggaccatt gatgactcta tcagacatgc cataacaaaa ctggctcatt     1980

atcatgtgtg ctgcacccgc agtgcagagc agcacctgat atccatgtgt gaggaccatg     2040

atcgcatcct tttggcaggc tgcccttcct atgacaaact tctctcagcc aagaacaaag     2100

actacatgag catcattcgc atgtggctag gtgatgatgt aaaatctaaa gattacattg     2160

ttgcactaca gcaccctgtg accactgaca ttaagcattc cataaaaatg tttgaattaa     2220

cattggatgc acttatctca tttaacaagc ggaccctagt cctgtttcca aatattgacg     2280

cagggagcaa agagatggtt nnngtgatgn nnaagaaggg cattgagcat catcccaact     2340

ttcgtgcagt taaacacgtc ccatttgacc agtttataca gttggttgcc catgctggct     2400

gtatgattgg gaacagcagc tgtggggttc gagaagttgg agcttttgga acacctgtga     2460

tcaacctggg aacacgtcag attggaagag aaacagggga gaatgttctt catgtccggg     2520

atgctgacac ccaagacaaa atattgcaag cactgcacct tcagtttggt aaacagtacc     2580

cttgttcaaa gatatatggg gatggaaatg ctgttccaag gattttgaag tttctcaaat     2640

ctatcgatct tcaagagcca ctgcaaaaga aattctgctt tcctcctgtg aaggagaata     2700

tctctcaaga tattgaccat attcttgaaa ctctaagtgc cttggccgtt gatcttggcg     2760

ggacgaacct ccgagttgca atagtcagca tgaagggtga aatagttaag aagtatactc     2820

agttcaatcc taaaacctat gaagagagga ttaatttaat cctacagatg tgtgtggaag     2880

ctgcagcaga agctgtaaaa ctgaactgca gaattttggg agtaggcatt tccacaggtg     2940

gccgtgtaaa tcctcgggaa ggaattgtgc tgcattcaac caaactgatc caagagtgga     3000

actctgtgga ccttaggacc cccctttctg acactttgca tctccctgtg tgggtagaca     3060

atgatggcaa ctgtgctgcc ctggcggaaa ggaaatttgg ccaaggaaag ggactggaaa     3120

actttgttac acttatcaca ggcacaggaa tcggtggtgg aattatccat cagcatgaat     3180

tgatccacgg aagctccttc tgtgctgcag aactgggcca ccttgttgtg tctctggatg     3240

ggcctgattg ttcctgtgga agccatgggt gcattgaagc atacgcctct ggaatggcct     3300

tgcagaggga ggcaaaaaag ctccatgatg aggacctgct cttggtggaa gggatgtcag     3360

tgccaaaaga tgaggctgtg ggtgcgctcc atctcatcca agctgcgaaa cttggcaatg     3420

cgaaggccca gagcatccta agaacagctg gaacagcttt gggtcttggg gttgtgaaca     3480

tcctccatac catgaatccc tcccttgtga tcctctccgg agtcctggcc agtcactata     3540

tccacattgt caaagacgtc attcgccagc aggccttgtc ctccgtgcag gacgtggatg     3600

tggtggtttc ggatttggtt gaccccgccc tgctgggtgc tgccagcatg gttctggact     3660

acacaacacg caggatctac tagtaagatc tttttccctc tgccaaaaat tatggggaca     3720

tcatgaagcc ccttgagcat ctgacttctg gctaataaag gaaatttatt ttcattgcaa     3780

tagtgtgttg gaattttttg tgtctctcac tcggaaggac ataagggcgg ccgctagc       3838


<210>  2
<211>  4032
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (2495)..(2497)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (2504)..(2506)
<223>  n is a, c, g, or t

<400>  2
ccgcctaatg agcgggcttt tttttggctt gttgtccaca accgttaaac cttaaaagct       60

ttaaaagcct tatatattct tttttttctt ataaaactta aaaccttaga ggctatttaa      120

gttgctgatt tatattaatt ttattgttca aacatgagag cttagtacgt gaaacatgag      180

agcttagtac gttagccatg agagcttagt acgttagcca tgagggttta gttcgttaaa      240

catgagagct tagtacgtta aacatgagag cttagtacgt actatcaaca ggttgaactg      300

ctgatccacg ttgtggtaga attggtaaag agagtcgtgt aaaatatcga gttcgcacat      360

cttgttgtct gattattgat ttttggcgaa accatttgat catatgacaa gatgtgtatc      420

taccttaact taatgatttt gataaaaatc attaggatcc gctctagcca ctacgggtct      480

aggctgccca tgtaaggagg caaggcctgg ggacacccga gatgcctggt tataattaac      540

ccagacatgt ggctgccccc ccccccccaa cacctgctgc ctgctaaaaa taaccctgtc      600

cctggtggtc tagccactac gggtctaggc tgcccatgta aggaggcaag gcctggggac      660

acccgagatg cctggttata attaacccag acatgtggct gccccccccc ccccaacacc      720

tgctgcctgc taaaaataac cctgtccctg gtggtctagc cactacgggt ctaggctgcc      780

catgtaagga ggcaaggcct ggggacaccc gagatgcctg gttataatta acccagacat      840

gtggctgccc cccccccccc aacacctgct gcctgctaaa aataaccctg tccctggtgg      900

tctagaatca aggctgtggg ggactgaggg caggctgtaa caggcttggg ggccagggct      960

tatacgtgcc tgggactccc aaagtattac tgttccatgt tcccggcgaa gggccagctg     1020

tcccccgcca gctagactca gcacttagtt taggaaccag tgagcaagtc agcccttggg     1080

gcagcccata caaggccatg gggctgggca agctgcacgc ctgggtccgg ggtgggcacg     1140

gtgcccgggc aacgagctga aagctcatct gctctcaggg gcccctccct ggggacagcc     1200

cctcctggct agtcacaccc tgtaggctcc tctatataac ccaggggcac aggggctgcc     1260

cccgggtcac caccacctcc acagcacaga cagacactca ggagccagcc agccgcggct     1320

cgcatctctc cttcacgcgc ccgccgccct acctgaggcc gccatccacg ccggttgagt     1380

cgcgttctgc cgcctcccgc ctgtggtgcc tcctgaactg cgtccgccgt ctaggtaagt     1440

ttaaagctca ggtcgagacc gggcctttgt ccggcgctcc cttggagcct acctagactc     1500

agccggctct ccacgctttg cctgaccctg cttgctcaac tctagttctc tcgttaactt     1560

aatgagacag atagaaactg gtcttgtaga aacagagtag tcgcctgctt ttctgccagg     1620

tgctgacttc tctcccctgg gcttttttct ttttctcagg ttgaaaagaa gaagacgaag     1680

aagacgaaga agacaaaccg tcgtcgacat ggagaagaat ggaaataacc gaaagctgcg     1740

ggtttgtgtt gctacttgta accgtgcaga ttattctaaa cttgccccga tcatgtttgg     1800

cattaaaacc gaacctgagt tctttgaact tgatgttgtg gtacttggct ctcacctgat     1860

agatgactat ggaaatacat atcgaatgat tgaacaagat gactttgaca ttaacaccag     1920

gctacacaca attgtgaggg gagaagatga ggcagccatg gtggagtcag taggcctggc     1980

cctagtgaag ctgccagatg tccttaatcg cctgaagcct gatatcatga ttgttcatgg     2040

agacaggttt gatgccctgg ctctggccac atctgctgcc ttgatgaaca tccgaatcct     2100

tcacattgaa ggtggggaag tcagtgggac cattgatgac tctatcagac atgccataac     2160

aaaactggct cattatcatg tgtgctgcac ccgcagtgca gagcagcacc tgatatccat     2220

gtgtgaggac catgatcgca tccttttggc aggctgccct tcctatgaca aacttctctc     2280

agccaagaac aaagactaca tgagcatcat tcgcatgtgg ctaggtgatg atgtaaaatc     2340

taaagattac attgttgcac tacagcaccc tgtgaccact gacattaagc attccataaa     2400

aatgtttgaa ttaacattgg atgcacttat ctcatttaac aagcggaccc tagtcctgtt     2460

tccaaatatt gacgcaggga gcaaagagat ggttnnngtg atgnnnaaga agggcattga     2520

gcatcatccc aactttcgtg cagttaaaca cgtcccattt gaccagttta tacagttggt     2580

tgcccatgct ggctgtatga ttgggaacag cagctgtggg gttcgagaag ttggagcttt     2640

tggaacacct gtgatcaacc tgggaacacg tcagattgga agagaaacag gggagaatgt     2700

tcttcatgtc cgggatgctg acacccaaga caaaatattg caagcactgc accttcagtt     2760

tggtaaacag tacccttgtt caaagatata tggggatgga aatgctgttc caaggatttt     2820

gaagtttctc aaatctatcg atcttcaaga gccactgcaa aagaaattct gctttcctcc     2880

tgtgaaggag aatatctctc aagatattga ccatattctt gaaactctaa gtgccttggc     2940

cgttgatctt ggcgggacga acctccgagt tgcaatagtc agcatgaagg gtgaaatagt     3000

taagaagtat actcagttca atcctaaaac ctatgaagag aggattaatt taatcctaca     3060

gatgtgtgtg gaagctgcag cagaagctgt aaaactgaac tgcagaattt tgggagtagg     3120

catttccaca ggtggccgtg taaatcctcg ggaaggaatt gtgctgcatt caaccaaact     3180

gatccaagag tggaactctg tggaccttag gacccccctt tctgacactt tgcatctccc     3240

tgtgtgggta gacaatgatg gcaactgtgc tgccctggcg gaaaggaaat ttggccaagg     3300

aaagggactg gaaaactttg ttacacttat cacaggcaca ggaatcggtg gtggaattat     3360

ccatcagcat gaattgatcc acggaagctc cttctgtgct gcagaactgg gccaccttgt     3420

tgtgtctctg gatgggcctg attgttcctg tggaagccat gggtgcattg aagcatacgc     3480

ctctggaatg gccttgcaga gggaggcaaa aaagctccat gatgaggacc tgctcttggt     3540

ggaagggatg tcagtgccaa aagatgaggc tgtgggtgcg ctccatctca tccaagctgc     3600

gaaacttggc aatgcgaagg cccagagcat cctaagaaca gctggaacag ctttgggtct     3660

tggggttgtg aacatcctcc ataccatgaa tccctccctt gtgatcctct ccggagtcct     3720

ggccagtcac tatatccaca ttgtcaaaga cgtcattcgc cagcaggcct tgtcctccgt     3780

gcaggacgtg gatgtggtgg tttcggattt ggttgacccc gccctgctgg gtgctgccag     3840

catggttctg gactacacaa cacgcaggat ctactagtaa gatctttttc cctctgccaa     3900

aaattatggg gacatcatga agccccttga gcatctgact tctggctaat aaaggaaatt     3960

tattttcatt gcaatagtgt gttggaattt tttgtgtctc tcactcggaa ggacataagg     4020

gcggccgcta gc                                                         4032


<210>  3
<211>  722
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Met Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr 
1               5                   10                  15      


Cys Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile 
            20                  25                  30          


Lys Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser 
        35                  40                  45              


His Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp 
    50                  55                  60                  


Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro 
                85                  90                  95      


Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp 
            100                 105                 110         


Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile 
        115                 120                 125             


Arg Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp 
    130                 135                 140                 


Ser Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys 
145                 150                 155                 160 


Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp 
                165                 170                 175     


Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala 
            180                 185                 190         


Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp 
        195                 200                 205             


Val Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr 
    210                 215                 220                 


Asp Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu 
225                 230                 235                 240 


Ile Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala 
                245                 250                 255     


Gly Ser Lys Glu Met Val Xaa Val Met Xaa Lys Lys Gly Ile Glu His 
            260                 265                 270         


His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile 
        275                 280                 285             


Gln Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly 
    290                 295                 300                 


Val Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr 
305                 310                 315                 320 


Arg Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp 
                325                 330                 335     


Ala Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly 
            340                 345                 350         


Lys Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro 
        355                 360                 365             


Arg Ile Leu Lys Phe Leu Lys Ser Ile Asp Leu Gln Glu Pro Leu Gln 
    370                 375                 380                 


Lys Lys Phe Cys Phe Pro Pro Val Lys Glu Asn Ile Ser Gln Asp Ile 
385                 390                 395                 400 


Asp His Ile Leu Glu Thr Leu Ser Ala Leu Ala Val Asp Leu Gly Gly 
                405                 410                 415     


Thr Asn Leu Arg Val Ala Ile Val Ser Met Lys Gly Glu Ile Val Lys 
            420                 425                 430         


Lys Tyr Thr Gln Phe Asn Pro Lys Thr Tyr Glu Glu Arg Ile Asn Leu 
        435                 440                 445             


Ile Leu Gln Met Cys Val Glu Ala Ala Ala Glu Ala Val Lys Leu Asn 
    450                 455                 460                 


Cys Arg Ile Leu Gly Val Gly Ile Ser Thr Gly Gly Arg Val Asn Pro 
465                 470                 475                 480 


Arg Glu Gly Ile Val Leu His Ser Thr Lys Leu Ile Gln Glu Trp Asn 
                485                 490                 495     


Ser Val Asp Leu Arg Thr Pro Leu Ser Asp Thr Leu His Leu Pro Val 
            500                 505                 510         


Trp Val Asp Asn Asp Gly Asn Cys Ala Ala Leu Ala Glu Arg Lys Phe 
        515                 520                 525             


Gly Gln Gly Lys Gly Leu Glu Asn Phe Val Thr Leu Ile Thr Gly Thr 
    530                 535                 540                 


Gly Ile Gly Gly Gly Ile Ile His Gln His Glu Leu Ile His Gly Ser 
545                 550                 555                 560 


Ser Phe Cys Ala Ala Glu Leu Gly His Leu Val Val Ser Leu Asp Gly 
                565                 570                 575     


Pro Asp Cys Ser Cys Gly Ser His Gly Cys Ile Glu Ala Tyr Ala Ser 
            580                 585                 590         


Gly Met Ala Leu Gln Arg Glu Ala Lys Lys Leu His Asp Glu Asp Leu 
        595                 600                 605             


Leu Leu Val Glu Gly Met Ser Val Pro Lys Asp Glu Ala Val Gly Ala 
    610                 615                 620                 


Leu His Leu Ile Gln Ala Ala Lys Leu Gly Asn Ala Lys Ala Gln Ser 
625                 630                 635                 640 


Ile Leu Arg Thr Ala Gly Thr Ala Leu Gly Leu Gly Val Val Asn Ile 
                645                 650                 655     


Leu His Thr Met Asn Pro Ser Leu Val Ile Leu Ser Gly Val Leu Ala 
            660                 665                 670         


Ser His Tyr Ile His Ile Val Lys Asp Val Ile Arg Gln Gln Ala Leu 
        675                 680                 685             


Ser Ser Val Gln Asp Val Asp Val Val Val Ser Asp Leu Val Asp Pro 
    690                 695                 700                 


Ala Leu Leu Gly Ala Ala Ser Met Val Leu Asp Tyr Thr Thr Arg Arg 
705                 710                 715                 720 


Ile Tyr 
        


<210>  4
<211>  400
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Thr Tyr Gly Tyr Leu Gln Arg Glu Ser Cys Phe Gln Gly Pro 
1               5                   10                  15      


His Glu Leu Tyr Phe Lys Asn Leu Ser Lys Arg Asn Lys Gln Ile Met 
            20                  25                  30          


Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr Cys 
        35                  40                  45              


Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile Lys 
    50                  55                  60                  


Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser His 
65                  70                  75                  80  


Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp Asp 
                85                  90                  95      


Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp Glu 
            100                 105                 110         


Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro Asp 
        115                 120                 125             


Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp Arg 
    130                 135                 140                 


Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile Arg 
145                 150                 155                 160 


Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp Ser 
                165                 170                 175     


Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys Thr 
            180                 185                 190         


Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp Arg 
        195                 200                 205             


Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala Lys 
    210                 215                 220                 


Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp Val 
225                 230                 235                 240 


Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr Asp 
                245                 250                 255     


Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu Ile 
            260                 265                 270         


Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly 
        275                 280                 285             


Ser Lys Glu Met Val Arg Val Met Arg Lys Lys Gly Ile Glu His His 
    290                 295                 300                 


Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile Gln 
305                 310                 315                 320 


Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly Val 
                325                 330                 335     


Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr Arg 
            340                 345                 350         


Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp Ala 
        355                 360                 365             


Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly Lys 
    370                 375                 380                 


Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro Arg 
385                 390                 395                 400 


<210>  5
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr 
1               5                   10                  15      


Cys Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile 
            20                  25                  30          


Lys Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser 
        35                  40                  45              


His Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp 
    50                  55                  60                  


Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro 
                85                  90                  95      


Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp 
            100                 105                 110         


Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile 
        115                 120                 125             


Arg Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp 
    130                 135                 140                 


Ser Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys 
145                 150                 155                 160 


Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp 
                165                 170                 175     


Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala 
            180                 185                 190         


Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp 
        195                 200                 205             


Val Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr 
    210                 215                 220                 


Asp Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu 
225                 230                 235                 240 


Ile Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala 
                245                 250                 255     


Gly Ser Lys Glu Met Val Arg Val Met Arg Lys Lys Gly Ile Glu His 
            260                 265                 270         


His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile 
        275                 280                 285             


Gln Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly 
    290                 295                 300                 


Val Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr 
305                 310                 315                 320 


Arg Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp 
                325                 330                 335     


Ala Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly 
            340                 345                 350         


Lys Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro 
        355                 360                 365             


Arg 
    


<210>  6
<211>  364
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ile Gly Asp Cys Ser Val Ala Ala Lys Pro Arg Lys Gln Leu 
1               5                   10                  15      


Leu Cys Ser Leu Phe Gln Thr Thr Leu Gly Tyr Arg Ala Arg Ala Ser 
            20                  25                  30          


Gly Trp Lys Pro Met Val Ile Cys Arg Gly Ser His Ala Phe Lys Asp 
        35                  40                  45              


Leu Ile Asn Thr Tyr Arg Met Ile Glu Gln Asp Asp Phe Asp Ile Asn 
    50                  55                  60                  


Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp Glu Ala Ala Met Val 
65                  70                  75                  80  


Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro Asp Val Leu Asn Arg 
                85                  90                  95      


Leu Lys Pro Asp Ile Met Ile Val His Gly Asp Arg Phe Asp Ala Leu 
            100                 105                 110         


Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile Arg Ile Leu His Ile 
        115                 120                 125             


Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp Ser Ile Arg His Ala 
    130                 135                 140                 


Ile Thr Lys Leu Ala His Tyr His Val Cys Cys Thr Arg Ser Ala Glu 
145                 150                 155                 160 


Gln His Leu Ile Ser Met Cys Glu Asp His Asp Arg Ile Leu Leu Ala 
                165                 170                 175     


Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala Lys Asn Lys Asp Tyr 
            180                 185                 190         


Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp Val Lys Ser Lys Asp 
        195                 200                 205             


Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr Asp Ile Lys His Ser 
    210                 215                 220                 


Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu Ile Ser Phe Asn Lys 
225                 230                 235                 240 


Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met 
                245                 250                 255     


Val Arg Val Met Arg Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            260                 265                 270         


Ala Val Lys His Val Pro Phe Asp Gln Phe Ile Gln Leu Val Ala His 
        275                 280                 285             


Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly Val Arg Glu Val Gly 
    290                 295                 300                 


Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr Arg Gln Ile Gly Arg 
305                 310                 315                 320 


Glu Thr Gly Glu Asn Val Leu His Val Arg Asp Ala Asp Thr Gln Asp 
                325                 330                 335     


Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly Lys Gln Tyr Pro Cys 
            340                 345                 350         


Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro Arg 
        355                 360                 


<210>  7
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr 
1               5                   10                  15      


Cys Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile 
            20                  25                  30          


Lys Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser 
        35                  40                  45              


His Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp 
    50                  55                  60                  


Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro 
                85                  90                  95      


Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp 
            100                 105                 110         


Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile 
        115                 120                 125             


Arg Asn Pro Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile 
    130                 135                 140                 


Asp Asp Ser Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val 
145                 150                 155                 160 


Cys Cys Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp 
                165                 170                 175     


His Asp Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu 
            180                 185                 190         


Ser Ala Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly 
        195                 200                 205             


Asp Asp Val Asn Pro Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His 
    210                 215                 220                 


Pro Val Thr Thr Asp Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr 
225                 230                 235                 240 


Leu Asp Ala Leu Ile Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro 
                245                 250                 255     


Asn Ile Asp Ala Gly Ser Lys Glu Met Val Arg Val Met Arg Lys Lys 
            260                 265                 270         


Gly Ile Glu His His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe 
        275                 280                 285             


Asp Gln Phe Ile Gln 
    290             


<210>  8
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ile Glu Gln Asp Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile 
1               5                   10                  15      


Val Arg Gly Glu Asp Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala 
            20                  25                  30          


Leu Val Lys Leu Pro Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met 
        35                  40                  45              


Ile Val His Gly Asp Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala 
    50                  55                  60                  


Ala Leu Met Asn Ile Arg Ile Leu His Ile Glu Gly Gly Glu Val Ser 
65                  70                  75                  80  


Gly Thr Ile Asp Asp Ser Ile Arg His Ala Ile Thr Lys Leu Ala His 
                85                  90                  95      


Tyr His Val Cys Cys Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met 
            100                 105                 110         


Cys Glu Asp His Asp Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp 
        115                 120                 125             


Lys Leu Leu Ser Ala Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met 
    130                 135                 140                 


Trp Leu Gly Ser Lys Glu Met Val Arg Val Met Arg Lys Lys Gly Ile 
145                 150                 155                 160 


Glu His His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln 
                165                 170                 175     


Phe Ile Gln 
            


<210>  9
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  9

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Arg Val Met Arg Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  10
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Gln Val Met Arg Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  11
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  11

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Trp Val Met Arg Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  12
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  12

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Leu Val Met Arg Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  13
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  13

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Arg Val Met Gln Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  14
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  14

Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly Ser Lys Glu Met Val 
1               5                   10                  15      


Arg Val Met Trp Lys Lys Gly Ile Glu His His Pro Asn Phe Arg 
            20                  25                  30      


<210>  15
<211>  753
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (294)..(294)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid

<400>  15

Met Glu Thr Tyr Gly Tyr Leu Gln Arg Glu Ser Cys Phe Gln Gly Pro 
1               5                   10                  15      


His Glu Leu Tyr Phe Lys Asn Leu Ser Lys Arg Asn Lys Gln Ile Met 
            20                  25                  30          


Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr Cys 
        35                  40                  45              


Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile Lys 
    50                  55                  60                  


Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser His 
65                  70                  75                  80  


Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp Asp 
                85                  90                  95      


Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp Glu 
            100                 105                 110         


Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro Asp 
        115                 120                 125             


Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp Arg 
    130                 135                 140                 


Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile Arg 
145                 150                 155                 160 


Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp Ser 
                165                 170                 175     


Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys Thr 
            180                 185                 190         


Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp Arg 
        195                 200                 205             


Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala Lys 
    210                 215                 220                 


Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp Val 
225                 230                 235                 240 


Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr Asp 
                245                 250                 255     


Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu Ile 
            260                 265                 270         


Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala Gly 
        275                 280                 285             


Ser Lys Glu Met Val Xaa Val Met Xaa Lys Lys Gly Ile Glu His His 
    290                 295                 300                 


Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile Gln 
305                 310                 315                 320 


Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly Val 
                325                 330                 335     


Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr Arg 
            340                 345                 350         


Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp Ala 
        355                 360                 365             


Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly Lys 
    370                 375                 380                 


Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro Arg 
385                 390                 395                 400 


Ile Leu Lys Phe Leu Lys Ser Ile Asp Leu Gln Glu Pro Leu Gln Lys 
                405                 410                 415     


Lys Phe Cys Phe Pro Pro Val Lys Glu Asn Ile Ser Gln Asp Ile Asp 
            420                 425                 430         


His Ile Leu Glu Thr Leu Ser Ala Leu Ala Val Asp Leu Gly Gly Thr 
        435                 440                 445             


Asn Leu Arg Val Ala Ile Val Ser Met Lys Gly Glu Ile Val Lys Lys 
    450                 455                 460                 


Tyr Thr Gln Phe Asn Pro Lys Thr Tyr Glu Glu Arg Ile Asn Leu Ile 
465                 470                 475                 480 


Leu Gln Met Cys Val Glu Ala Ala Ala Glu Ala Val Lys Leu Asn Cys 
                485                 490                 495     


Arg Ile Leu Gly Val Gly Ile Ser Thr Gly Gly Arg Val Asn Pro Arg 
            500                 505                 510         


Glu Gly Ile Val Leu His Ser Thr Lys Leu Ile Gln Glu Trp Asn Ser 
        515                 520                 525             


Val Asp Leu Arg Thr Pro Leu Ser Asp Thr Leu His Leu Pro Val Trp 
    530                 535                 540                 


Val Asp Asn Asp Gly Asn Cys Ala Ala Leu Ala Glu Arg Lys Phe Gly 
545                 550                 555                 560 


Gln Gly Lys Gly Leu Glu Asn Phe Val Thr Leu Ile Thr Gly Thr Gly 
                565                 570                 575     


Ile Gly Gly Gly Ile Ile His Gln His Glu Leu Ile His Gly Ser Ser 
            580                 585                 590         


Phe Cys Ala Ala Glu Leu Gly His Leu Val Val Ser Leu Asp Gly Pro 
        595                 600                 605             


Asp Cys Ser Cys Gly Ser His Gly Cys Ile Glu Ala Tyr Ala Ser Gly 
    610                 615                 620                 


Met Ala Leu Gln Arg Glu Ala Lys Lys Leu His Asp Glu Asp Leu Leu 
625                 630                 635                 640 


Leu Val Glu Gly Met Ser Val Pro Lys Asp Glu Ala Val Gly Ala Leu 
                645                 650                 655     


His Leu Ile Gln Ala Ala Lys Leu Gly Asn Ala Lys Ala Gln Ser Ile 
            660                 665                 670         


Leu Arg Thr Ala Gly Thr Ala Leu Gly Leu Gly Val Val Asn Ile Leu 
        675                 680                 685             


His Thr Met Asn Pro Ser Leu Val Ile Leu Ser Gly Val Leu Ala Ser 
    690                 695                 700                 


His Tyr Ile His Ile Val Lys Asp Val Ile Arg Gln Gln Ala Leu Ser 
705                 710                 715                 720 


Ser Val Gln Asp Val Asp Val Val Val Ser Asp Leu Val Asp Pro Ala 
                725                 730                 735     


Leu Leu Gly Ala Ala Ser Met Val Leu Asp Tyr Thr Thr Arg Arg Ile 
            740                 745                 750         


Tyr 
    


<210>  16
<211>  648
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Met Glu Lys Asn Gly Asn Asn Arg Lys Leu Arg Val Cys Val Ala Thr 
1               5                   10                  15      


Cys Asn Arg Ala Asp Tyr Ser Lys Leu Ala Pro Ile Met Phe Gly Ile 
            20                  25                  30          


Lys Thr Glu Pro Glu Phe Phe Glu Leu Asp Val Val Val Leu Gly Ser 
        35                  40                  45              


His Leu Ile Asp Asp Tyr Gly Asn Thr Tyr Arg Met Ile Glu Gln Asp 
    50                  55                  60                  


Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile Val Arg Gly Glu Asp 
65                  70                  75                  80  


Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala Leu Val Lys Leu Pro 
                85                  90                  95      


Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met Ile Val His Gly Asp 
            100                 105                 110         


Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala Ala Leu Met Asn Ile 
        115                 120                 125             


Arg Ile Leu His Ile Glu Gly Gly Glu Val Ser Gly Thr Ile Asp Asp 
    130                 135                 140                 


Ser Ile Arg His Ala Ile Thr Lys Leu Ala His Tyr His Val Cys Cys 
145                 150                 155                 160 


Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met Cys Glu Asp His Asp 
                165                 170                 175     


Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp Lys Leu Leu Ser Ala 
            180                 185                 190         


Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met Trp Leu Gly Asp Asp 
        195                 200                 205             


Val Lys Ser Lys Asp Tyr Ile Val Ala Leu Gln His Pro Val Thr Thr 
    210                 215                 220                 


Asp Ile Lys His Ser Ile Lys Met Phe Glu Leu Thr Leu Asp Ala Leu 
225                 230                 235                 240 


Ile Ser Phe Asn Lys Arg Thr Leu Val Leu Phe Pro Asn Ile Asp Ala 
                245                 250                 255     


Gly Ser Lys Glu Met Val Xaa Val Met Xaa Lys Lys Gly Ile Glu His 
            260                 265                 270         


His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln Phe Ile 
        275                 280                 285             


Gln Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser Cys Gly 
    290                 295                 300                 


Val Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu Gly Thr 
305                 310                 315                 320 


Arg Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val Arg Asp 
                325                 330                 335     


Ala Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln Phe Gly 
            340                 345                 350         


Lys Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala Val Pro 
        355                 360                 365             


Arg Ile Leu Lys Phe Leu Lys Ser Ile Asp Leu Gln Glu Pro Leu Gln 
    370                 375                 380                 


Lys Lys Phe Cys Phe Pro Pro Val Lys Glu Asn Ile Ser Gln Asp Ile 
385                 390                 395                 400 


Asp His Ile Leu Glu Thr Leu Ser Ala Leu Ala Val Asp Leu Gly Gly 
                405                 410                 415     


Thr Asn Leu Arg Val Ala Ile Val Ser Met Lys Gly Glu Ile Val Lys 
            420                 425                 430         


Lys Tyr Thr Gln Phe Asn Pro Lys Thr Tyr Glu Glu Arg Ile Asn Leu 
        435                 440                 445             


Ile Leu Gln Met Cys Val Glu Ala Ala Ala Glu Ala Val Lys Leu Asn 
    450                 455                 460                 


Cys Arg Ile Leu Gly Val Gly Ile Gly Gly Gly Ile Ile His Gln His 
465                 470                 475                 480 


Glu Leu Ile His Gly Ser Ser Phe Cys Ala Ala Glu Leu Gly His Leu 
                485                 490                 495     


Val Val Ser Leu Asp Gly Pro Asp Cys Ser Cys Gly Ser His Gly Cys 
            500                 505                 510         


Ile Glu Ala Tyr Ala Ser Gly Met Ala Leu Gln Arg Glu Ala Lys Lys 
        515                 520                 525             


Leu His Asp Glu Asp Leu Leu Leu Val Glu Gly Met Ser Val Pro Lys 
    530                 535                 540                 


Asp Glu Ala Val Gly Ala Leu His Leu Ile Gln Ala Ala Lys Leu Gly 
545                 550                 555                 560 


Asn Ala Lys Ala Gln Ser Ile Leu Arg Thr Ala Gly Thr Ala Leu Gly 
                565                 570                 575     


Leu Gly Val Val Asn Ile Leu His Thr Met Asn Pro Ser Leu Val Ile 
            580                 585                 590         


Leu Ser Gly Val Leu Ala Ser His Tyr Ile His Ile Val Lys Asp Val 
        595                 600                 605             


Ile Arg Gln Gln Ala Leu Ser Ser Val Gln Asp Val Asp Val Val Val 
    610                 615                 620                 


Ser Asp Leu Val Asp Pro Ala Leu Leu Gly Ala Ala Ser Met Val Leu 
625                 630                 635                 640 


Asp Tyr Thr Thr Arg Arg Ile Tyr 
                645             


<210>  17
<211>  612
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (153)..(153)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (156)..(156)
<223>  Xaa can be any naturally occurring amino acid

<400>  17

Met Ile Glu Gln Asp Asp Phe Asp Ile Asn Thr Arg Leu His Thr Ile 
1               5                   10                  15      


Val Arg Gly Glu Asp Glu Ala Ala Met Val Glu Ser Val Gly Leu Ala 
            20                  25                  30          


Leu Val Lys Leu Pro Asp Val Leu Asn Arg Leu Lys Pro Asp Ile Met 
        35                  40                  45              


Ile Val His Gly Asp Arg Phe Asp Ala Leu Ala Leu Ala Thr Ser Ala 
    50                  55                  60                  


Ala Leu Met Asn Ile Arg Ile Leu His Ile Glu Gly Gly Glu Val Ser 
65                  70                  75                  80  


Gly Thr Ile Asp Asp Ser Ile Arg His Ala Ile Thr Lys Leu Ala His 
                85                  90                  95      


Tyr His Val Cys Cys Thr Arg Ser Ala Glu Gln His Leu Ile Ser Met 
            100                 105                 110         


Cys Glu Asp His Asp Arg Ile Leu Leu Ala Gly Cys Pro Ser Tyr Asp 
        115                 120                 125             


Lys Leu Leu Ser Ala Lys Asn Lys Asp Tyr Met Ser Ile Ile Arg Met 
    130                 135                 140                 


Trp Leu Gly Ser Lys Glu Met Val Xaa Val Met Xaa Lys Lys Gly Ile 
145                 150                 155                 160 


Glu His His Pro Asn Phe Arg Ala Val Lys His Val Pro Phe Asp Gln 
                165                 170                 175     


Phe Ile Gln Leu Val Ala His Ala Gly Cys Met Ile Gly Asn Ser Ser 
            180                 185                 190         


Cys Gly Val Arg Glu Val Gly Ala Phe Gly Thr Pro Val Ile Asn Leu 
        195                 200                 205             


Gly Thr Arg Gln Ile Gly Arg Glu Thr Gly Glu Asn Val Leu His Val 
    210                 215                 220                 


Arg Asp Ala Asp Thr Gln Asp Lys Ile Leu Gln Ala Leu His Leu Gln 
225                 230                 235                 240 


Phe Gly Lys Gln Tyr Pro Cys Ser Lys Ile Tyr Gly Asp Gly Asn Ala 
                245                 250                 255     


Val Pro Arg Ile Leu Lys Phe Leu Lys Ser Ile Asp Leu Gln Glu Pro 
            260                 265                 270         


Leu Gln Lys Lys Phe Cys Phe Pro Pro Val Lys Glu Asn Ile Ser Gln 
        275                 280                 285             


Asp Ile Asp His Ile Leu Glu Thr Leu Ser Ala Leu Ala Val Asp Leu 
    290                 295                 300                 


Gly Gly Thr Asn Leu Arg Val Ala Ile Val Ser Met Lys Gly Glu Ile 
305                 310                 315                 320 


Val Lys Lys Tyr Thr Gln Phe Asn Pro Lys Thr Tyr Glu Glu Arg Ile 
                325                 330                 335     


Asn Leu Ile Leu Gln Met Cys Val Glu Ala Ala Ala Glu Ala Val Lys 
            340                 345                 350         


Leu Asn Cys Arg Ile Leu Gly Val Gly Ile Ser Thr Gly Gly Arg Val 
        355                 360                 365             


Asn Pro Arg Glu Gly Ile Val Leu His Ser Thr Lys Leu Ile Gln Glu 
    370                 375                 380                 


Trp Asn Ser Val Asp Leu Arg Thr Pro Leu Ser Asp Thr Leu His Leu 
385                 390                 395                 400 


Pro Val Trp Val Asp Asn Asp Gly Asn Cys Ala Ala Leu Ala Glu Arg 
                405                 410                 415     


Lys Phe Gly Gln Gly Lys Gly Leu Glu Asn Phe Val Thr Leu Ile Thr 
            420                 425                 430         


Gly Thr Gly Ile Gly Gly Gly Ile Ile His Gln His Glu Leu Ile His 
        435                 440                 445             


Gly Ser Ser Phe Cys Ala Ala Glu Leu Gly His Leu Val Val Ser Leu 
    450                 455                 460                 


Asp Gly Pro Asp Cys Ser Cys Gly Ser His Gly Cys Ile Glu Ala Tyr 
465                 470                 475                 480 


Ala Ser Gly Met Ala Leu Gln Arg Glu Ala Lys Lys Leu His Asp Glu 
                485                 490                 495     


Asp Leu Leu Leu Val Glu Gly Met Ser Val Pro Lys Asp Glu Ala Val 
            500                 505                 510         


Gly Ala Leu His Leu Ile Gln Ala Ala Lys Leu Gly Asn Ala Lys Ala 
        515                 520                 525             


Gln Ser Ile Leu Arg Thr Ala Gly Thr Ala Leu Gly Leu Gly Val Val 
    530                 535                 540                 


Asn Ile Leu His Thr Met Asn Pro Ser Leu Val Ile Leu Ser Gly Val 
545                 550                 555                 560 


Leu Ala Ser His Tyr Ile His Ile Val Lys Asp Val Ile Arg Gln Gln 
                565                 570                 575     


Ala Leu Ser Ser Val Gln Asp Val Asp Val Val Val Ser Asp Leu Val 
            580                 585                 590         


Asp Pro Ala Leu Leu Gly Ala Ala Ser Met Val Leu Asp Tyr Thr Thr 
        595                 600                 605             


Arg Arg Ile Tyr 
    610         


<210>  18
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  18

Asp Asn Ala Tyr Phe Gly Tyr Ser Thr Pro Trp Gly Tyr Phe Asp Phe 
1               5                   10                  15      


Asn Arg Phe His Cys His Phe Ser Pro Arg Asp Trp Gln Arg Leu Ile 
            20                  25                  30          


Asn Asn Asn Trp Gly Phe Arg Pro Lys Arg Leu Asn Phe Lys Leu Phe 
        35                  40                  45              


Asn Ile Gln Val Lys Glu Val Thr Asp Asn Asn Gly Val Lys Thr Ile 
    50                  55                  60                  


Ala Asn Asn Leu Thr Ser Thr Val Gln Val Phe Thr Asp Ser Asp Tyr 
65                  70                  75                  80  


Gln Leu Pro Tyr Val Leu Gly Ser Ala His Glu Gly Cys Leu Pro Pro 
                85                  90                  95      


Phe Pro Ala Asp Val Phe Met Ile Pro Gln Tyr Gly Tyr Leu Thr Leu 
            100                 105                 110         


Asn Asp Gly Ser Gln Ala Val Gly Arg Ser Ser Phe Tyr Cys Leu Glu 
        115                 120                 125             


Tyr Phe Pro Ser Gln Met Leu Arg Thr Gly Asn Asn Phe Gln Phe Ser 
    130                 135                 140                 


Tyr Glu Phe Glu Asn Val Pro Phe His Ser Ser Tyr Ala His Ser Gln 
145                 150                 155                 160 


Ser Leu Asp Arg Leu Met Asn Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr 
                165                 170                 175     


Leu Ser Lys Thr Ile Asn Gly Ser Gly Gln Asn Gln Gln Thr Leu Lys 
            180                 185                 190         


Phe Ser Val Ala Gly Pro Ser Asn Met Ala Val Gln Gly Arg Asn Tyr 
        195                 200                 205             


Ile Pro Gly Pro Ser Tyr Arg Gln Gln Arg Val Ser Thr Thr Val Thr 
    210                 215                 220                 


Gln Asn Asn Asn Ser Glu Phe Ala Trp Asp Asn Ala Tyr Phe Gly Tyr 
225                 230                 235                 240 


Ser Thr Pro Trp Gly Tyr Phe Asp Phe Asn Arg Phe His Cys His Phe 
                245                 250                 255     


Ser Pro Arg Asp Trp Gln Arg Leu Ile Asn Asn Asn Trp Gly Phe Arg 
            260                 265                 270         


Pro Lys Arg Leu Asn Phe Lys Leu Phe Asn Ile Gln Val Lys Glu Val 
        275                 280                 285             


Thr Asp Asn Asn Gly Val Lys Thr Ile Ala Asn Asn Leu Thr Ser Thr 
    290                 295                 300                 


Val Gln Val Phe Thr Asp Ser Asp Tyr Gln Leu Pro Tyr Val Leu Gly 
305                 310                 315                 320 


Ser Ala His Glu Gly Cys Leu Pro Pro Phe Pro Ala Asp Val Phe Met 
                325                 330                 335     


Ile Pro Gln Tyr Gly Tyr Leu Thr Leu Asn Asp Gly Ser Gln Ala Val 
            340                 345                 350         


Gly Arg Ser Ser Phe Tyr Cys Leu Glu Tyr Phe Pro Ser Gln Met Leu 
        355                 360                 365             


Arg Thr Gly Asn Asn Phe Gln Phe Ser Tyr Glu Phe Glu Asn Val Pro 
    370                 375                 380                 


Phe His Ser Ser Tyr Ala His Ser Gln Ser Leu Asp Arg Leu Met Asn 
385                 390                 395                 400 


Pro Leu Ile Asp Gln Tyr Leu Tyr Tyr Leu Ser Lys Thr Ile Asn Gly 
                405                 410                 415     


Ser Gly Gln Asn Gln Gln Thr Leu Lys Phe Ser Val Ala Gly Pro Ser 
            420                 425                 430         


Asn Met Ala Val Gln Gly Arg Asn Tyr Ile Pro Gly Pro Ser Tyr Arg 
        435                 440                 445             


Gln Gln Arg Val Ser Thr Thr Val Thr Gln Asn Asn Asn Ser Glu Phe 
    450                 455                 460                 


Ala Trp 
465     


<210>  19
<211>  233
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (3)..(175)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (177)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (201)..(201)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(232)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Asp Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Asn Xaa Ala Val Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Trp 
225                 230             


