                         SEQUENCE LISTING

<110>  The National Institute for Biotechnology in the Negev, LTD
 
<120>  IL-2 CHIMERIC PROTEINS FOR IMMUNOSUPRESSION

<130>  NIBN-P-035-PCT

<150>  62/903,855
<151>  2019-09-22

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  270
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Trp Arg Ala Leu His Pro Leu Leu Leu Leu Leu Leu Leu Phe 
1               5                   10                  15      


Pro Gly Ser Gln Ala Gln Ser Lys Ala Gln Val Leu Gln Ser Val Ala 
            20                  25                  30          


Gly Gln Thr Leu Thr Val Arg Cys Gln Tyr Pro Pro Thr Gly Ser Leu 
        35                  40                  45              


Tyr Glu Lys Lys Gly Trp Cys Lys Glu Ala Ser Ala Leu Val Cys Ile 
    50                  55                  60                  


Arg Leu Val Thr Ser Ser Lys Pro Arg Thr Met Ala Trp Thr Ser Arg 
65                  70                  75                  80  


Phe Thr Ile Trp Asp Asp Pro Asp Ala Gly Phe Phe Thr Val Thr Met 
                85                  90                  95      


Thr Asp Leu Arg Glu Glu Asp Ser Gly His Tyr Trp Cys Arg Ile Tyr 
            100                 105                 110         


Arg Pro Ser Asp Asn Ser Val Ser Lys Ser Val Arg Phe Tyr Leu Val 
        115                 120                 125             


Val Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp 
    130                 135                 140                 


Leu Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala 
145                 150                 155                 160 


Gly Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser 
                165                 170                 175     


His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn 
            180                 185                 190         


Ser Thr Leu Arg Pro Gly Pro Ala Ala Pro Ile Ala Leu Val Pro Val 
        195                 200                 205             


Phe Cys Gly Leu Leu Val Ala Lys Ser Leu Val Leu Ser Ala Leu Leu 
    210                 215                 220                 


Val Trp Trp Val Leu Arg Asn Arg His Met Gln His Gln Gly Arg Ser 
225                 230                 235                 240 


Leu Leu His Pro Ala Gln Pro Arg Pro Gln Ala His Arg His Phe Pro 
                245                 250                 255     


Leu Ser His Arg Ala Pro Gly Gly Thr Tyr Gly Gly Lys Pro 
            260                 265                 270 


<210>  2
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg 
        


<210>  3
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro 
        35      


<210>  4
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser Ala Ser Thr Gln Thr 
                165                 170                 175     


Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser 
            180                 185                 190         


Cys Val Pro Pro Thr Ala Gly Ala Arg 
        195                 200     


<210>  5
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  5

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
        35                  40                  45              


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
    50                  55                  60                  


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
65                  70                  75                  80  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
                85                  90                  95      


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
            100                 105                 110         


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
        115                 120                 125             


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
    130                 135                 140                 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser 
                165                 170                 175     


Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu 
            180                 185                 190         


Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200                 205 


<210>  6
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser Thr Ile 
                165                 170                 175     


Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser 
            180                 185                 190         


Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200             


<210>  7
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
        35                  40                  45              


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
    50                  55                  60                  


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
65                  70                  75                  80  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
                85                  90                  95      


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
            100                 105                 110         


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
        115                 120                 125             


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
    130                 135                 140                 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser Ala Ser Thr 
                165                 170                 175     


Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr 
            180                 185                 190         


Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg 
        195                 200             


<210>  8
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asp Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  9
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser 
            20  


<210>  10
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  10

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His 
        35                  40                  45              


Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser 
    50                  55                  60                  


Thr Leu Arg Pro Gly Pro 
65                  70  


<210>  11
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  11

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His 
        35                  40                  45              


Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Ala Ser 
    50                  55                  60                  


Thr Leu Arg Pro Gly Pro 
65                  70  


<210>  12
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Tyr Arg Met Gln Leu Leu Ser Cys Ile Ala Leu Ser Leu Ala Leu 
1               5                   10                  15      


Val Thr Asn Ser Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
            20                  25                  30          


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
        35                  40                  45              


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
    50                  55                  60                  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
65                  70                  75                  80  


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
                85                  90                  95      


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile 
            100                 105                 110         


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
        115                 120                 125             


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
    130                 135                 140                 


Cys Gln Ser Ile Ile Ser Thr Leu Thr 
145                 150             


<210>  13
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu Glu His 
1               5                   10                  15      


Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn Tyr Lys 
            20                  25                  30          


Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met Pro Lys 
        35                  40                  45              


Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu Leu Lys 
    50                  55                  60                  


Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe His Leu 
65                  70                  75                  80  


Arg Pro Arg Asp Leu Ile Ser Asn Ile Asn Val Ile Val Leu Glu Leu 
                85                  90                  95      


Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu Thr Ala 
            100                 105                 110         


Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln Ser Ile 
        115                 120                 125             


Ile Ser Thr Leu Thr 
    130             


<210>  14
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asp Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser Thr Ile 
                165                 170                 175     


Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu Pro Ser 
            180                 185                 190         


Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200             


<210>  15
<211>  201
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Ser Pro Ala Ser Ala Ser Thr Gln Thr Ser Trp Thr Pro Arg Asp Leu 
1               5                   10                  15      


Val Ser Ser Gln Thr Gln Thr Gln Ser Cys Val Pro Pro Thr Ala Gly 
            20                  25                  30          


Ala Arg Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu Gln Leu 
        35                  40                  45              


Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile Asn Asn 
    50                  55                  60                  


Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe Tyr Met 
65                  70                  75                  80  


Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu Glu Glu 
                85                  90                  95      


Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys Asn Phe 
            100                 105                 110         


His Leu Arg Pro Arg Asp Leu Ile Ser Asp Ile Asn Val Ile Val Leu 
        115                 120                 125             


Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala Asp Glu 
    130                 135                 140                 


Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe Cys Gln 
145                 150                 155                 160 


Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser Ala Ser Thr Gln Thr 
                165                 170                 175     


Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr Gln Ser 
            180                 185                 190         


Cys Val Pro Pro Thr Ala Gly Ala Arg 
        195                 200     


<210>  16
<211>  205
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
        35                  40                  45              


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
    50                  55                  60                  


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
65                  70                  75                  80  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
                85                  90                  95      


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
            100                 105                 110         


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asp Ile Asn Val Ile 
        115                 120                 125             


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
    130                 135                 140                 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Gln Ala Pro Glu Ser Pro Ser 
                165                 170                 175     


Thr Ile Pro Val Pro Ser His Pro Ser Ser Pro Leu Pro Val Pro Leu 
            180                 185                 190         


Pro Ser Arg Pro Gln Asn Ser Thr Leu Arg Pro Gly Pro 
        195                 200                 205 


<210>  17
<211>  203
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Gln Ala Pro Glu Ser Pro Ser Thr Ile Pro Val Pro Ser His Pro Ser 
1               5                   10                  15      


Ser Pro Leu Pro Val Pro Leu Pro Ser Arg Pro Gln Asn Ser Thr Leu 
            20                  25                  30          


Arg Pro Gly Pro Ala Pro Thr Ser Ser Ser Thr Lys Lys Thr Gln Leu 
        35                  40                  45              


Gln Leu Glu His Leu Leu Leu Asp Leu Gln Met Ile Leu Asn Gly Ile 
    50                  55                  60                  


Asn Asn Tyr Lys Asn Pro Lys Leu Thr Arg Met Leu Thr Phe Lys Phe 
65                  70                  75                  80  


Tyr Met Pro Lys Lys Ala Thr Glu Leu Lys His Leu Gln Cys Leu Glu 
                85                  90                  95      


Glu Glu Leu Lys Pro Leu Glu Glu Val Leu Asn Leu Ala Gln Ser Lys 
            100                 105                 110         


Asn Phe His Leu Arg Pro Arg Asp Leu Ile Ser Asp Ile Asn Val Ile 
        115                 120                 125             


Val Leu Glu Leu Lys Gly Ser Glu Thr Thr Phe Met Cys Glu Tyr Ala 
    130                 135                 140                 


Asp Glu Thr Ala Thr Ile Val Glu Phe Leu Asn Arg Trp Ile Thr Phe 
145                 150                 155                 160 


Cys Gln Ser Ile Ile Ser Thr Leu Thr Ser Pro Ala Ser Ala Ser Thr 
                165                 170                 175     


Gln Thr Ser Trp Thr Pro Arg Asp Leu Val Ser Ser Gln Thr Gln Thr 
            180                 185                 190         


Gln Ser Cys Val Pro Pro Thr Ala Gly Ala Arg 
        195                 200             


