                         SEQUENCE LISTING

<110>  STRATA SKIN SCIENCES
 
<120>  METHOD FOR TARGETED TREATING DERMATOSES

<130>  STRT/001 USP

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  1148
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gln Tyr Leu Asn Ile Lys Glu Asp Cys Asn Ala Met Ala Phe Cys 
1               5                   10                  15      


Ala Lys Met Arg Ser Ser Lys Lys Thr Glu Leu Glu Ala Pro Glu Pro 
            20                  25                  30          


Gly Val Glu Val Ile Phe Tyr Leu Ser Asp Arg Glu Pro Leu Arg Leu 
        35                  40                  45              


Gly Ser Gly Glu Tyr Thr Ala Glu Glu Leu Cys Ile Arg Ala Ala Gln 
    50                  55                  60                  


Ala Cys Arg Ile Ser Pro Leu Cys His Asn Leu Phe Ala Leu Tyr Asp 
65                  70                  75                  80  


Glu Asn Thr Lys Leu Trp Tyr Ala Pro Asn Arg Thr Ile Thr Val Asp 
                85                  90                  95      


Asp Lys Met Ser Leu Arg Leu His Tyr Arg Met Arg Phe Tyr Phe Thr 
            100                 105                 110         


Asn Trp His Gly Thr Asn Asp Asn Glu Gln Ser Val Trp Arg His Ser 
        115                 120                 125             


Pro Lys Lys Gln Lys Asn Gly Tyr Glu Lys Lys Lys Ile Pro Asp Ala 
    130                 135                 140                 


Thr Pro Leu Leu Asp Ala Ser Ser Leu Glu Tyr Leu Phe Ala Gln Gly 
145                 150                 155                 160 


Gln Tyr Asp Leu Val Lys Cys Leu Ala Pro Ile Arg Asp Pro Lys Thr 
                165                 170                 175     


Glu Gln Asp Gly His Asp Ile Glu Asn Glu Cys Leu Gly Met Ala Val 
            180                 185                 190         


Leu Ala Ile Ser His Tyr Ala Met Met Lys Lys Met Gln Leu Pro Glu 
        195                 200                 205             


Leu Pro Lys Asp Ile Ser Tyr Lys Arg Tyr Ile Pro Glu Thr Leu Asn 
    210                 215                 220                 


Lys Ser Ile Arg Gln Arg Asn Leu Leu Thr Arg Met Arg Ile Asn Asn 
225                 230                 235                 240 


Val Phe Lys Asp Phe Leu Lys Glu Phe Asn Asn Lys Thr Ile Cys Asp 
                245                 250                 255     


Ser Ser Val Ser Thr His Asp Leu Lys Val Lys Tyr Leu Ala Thr Leu 
            260                 265                 270         


Glu Thr Leu Thr Lys His Tyr Gly Ala Glu Ile Phe Glu Thr Ser Met 
        275                 280                 285             


Leu Leu Ile Ser Ser Glu Asn Glu Met Asn Trp Phe His Ser Asn Asp 
    290                 295                 300                 


Gly Gly Asn Val Leu Tyr Tyr Glu Val Met Val Thr Gly Asn Leu Gly 
305                 310                 315                 320 


Ile Gln Trp Arg His Lys Pro Asn Trp Ser Val Glu Lys Glu Lys Asn 
                325                 330                 335     


Lys Leu Lys Arg Lys Lys Leu Glu Asn Lys His Lys Lys Asp Glu Glu 
            340                 345                 350         


Lys Asn Lys Ile Arg Glu Glu Trp Asn Asn Phe Ser Tyr Phe Pro Glu 
        355                 360                 365             


Ile Thr His Ile Val Ile Lys Glu Ser Trp Ser Ile Asn Lys Gln Asp 
    370                 375                 380                 


Asn Lys Lys Met Glu Leu Lys Leu Ser Ser His Glu Glu Ala Leu Ser 
385                 390                 395                 400 


Phe Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ala His 
                405                 410                 415     


His Tyr Leu Cys Thr Asp Val Ala Pro Pro Leu Ile Val His Asn Ile 
            420                 425                 430         


Gln Asn Gly Cys His Gly Pro Ile Cys Thr Glu Tyr Ala Ile Asn Lys 
        435                 440                 445             


Leu Arg Gln Glu Gly Ser Glu Glu Gly Met Tyr Val Leu Arg Trp Ser 
    450                 455                 460                 


Cys Thr Asp Phe Asp Asn Ile Leu Met Thr Val Thr Cys Phe Glu Lys 
465                 470                 475                 480 


Ser Glu Gln Val Gln Gly Ala Gln Lys Gln Phe Lys Asn Phe Gln Ile 
                485                 490                 495     


Glu Val Gln Lys Gly Arg Tyr Ser Leu His Gly Ser Asp Arg Ser Phe 
            500                 505                 510         


Pro Ser Leu Gly Asp Leu Met Ser His Leu Lys Lys Gln Ile Leu Arg 
        515                 520                 525             


Thr Asp Asn Ile Ser Phe Met Leu Lys Arg Cys Cys Gln Pro Lys Pro 
    530                 535                 540                 


Arg Glu Ile Ser Asn Leu Leu Val Ala Thr Lys Lys Ala Gln Glu Trp 
545                 550                 555                 560 


Gln Pro Val Tyr Pro Met Ser Gln Leu Ser Phe Asp Arg Ile Leu Lys 
                565                 570                 575     


Lys Asp Leu Val Gln Gly Glu His Leu Gly Arg Gly Thr Arg Thr His 
            580                 585                 590         


Ile Tyr Ser Gly Thr Leu Met Asp Tyr Lys Asp Asp Glu Gly Thr Ser 
        595                 600                 605             


Glu Glu Lys Lys Ile Lys Val Ile Leu Lys Val Leu Asp Pro Ser His 
    610                 615                 620                 


Arg Asp Ile Ser Leu Ala Phe Phe Glu Ala Ala Ser Met Met Arg Gln 
625                 630                 635                 640 


Val Ser His Lys His Ile Val Tyr Leu Tyr Gly Val Cys Val Arg Asp 
                645                 650                 655     


Val Glu Asn Ile Met Val Glu Glu Phe Val Glu Gly Gly Pro Leu Asp 
            660                 665                 670         


Leu Phe Met His Arg Lys Ser Asp Val Leu Thr Thr Pro Trp Lys Phe 
        675                 680                 685             


Lys Val Ala Lys Gln Leu Ala Ser Ala Leu Ser Tyr Leu Glu Asp Lys 
    690                 695                 700                 


Asp Leu Val His Gly Asn Val Cys Thr Lys Asn Leu Leu Leu Ala Arg 
705                 710                 715                 720 


Glu Gly Ile Asp Ser Glu Cys Gly Pro Phe Ile Lys Leu Ser Asp Pro 
                725                 730                 735     


Gly Ile Pro Ile Thr Val Leu Ser Arg Gln Glu Cys Ile Glu Arg Ile 
            740                 745                 750         


Pro Trp Ile Ala Pro Glu Cys Val Glu Asp Ser Lys Asn Leu Ser Val 
        755                 760                 765             


Ala Ala Asp Lys Trp Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Tyr 
    770                 775                 780                 


Asn Gly Glu Ile Pro Leu Lys Asp Lys Thr Leu Ile Glu Lys Glu Arg 
785                 790                 795                 800 


Phe Tyr Glu Ser Arg Cys Arg Pro Val Thr Pro Ser Cys Lys Glu Leu 
                805                 810                 815     


Ala Asp Leu Met Thr Arg Cys Met Asn Tyr Asp Pro Asn Gln Arg Pro 
            820                 825                 830         


Phe Phe Arg Ala Ile Met Arg Asp Ile Asn Lys Leu Glu Glu Gln Asn 
        835                 840                 845             


Pro Asp Ile Val Ser Glu Lys Lys Pro Ala Thr Glu Val Asp Pro Thr 
    850                 855                 860                 


His Phe Glu Lys Arg Phe Leu Lys Arg Ile Arg Asp Leu Gly Glu Gly 
865                 870                 875                 880 


His Phe Gly Lys Val Glu Leu Cys Arg Tyr Asp Pro Glu Gly Asp Asn 
                885                 890                 895     


Thr Gly Glu Gln Val Ala Val Lys Ser Leu Lys Pro Glu Ser Gly Gly 
            900                 905                 910         


Asn His Ile Ala Asp Leu Lys Lys Glu Ile Glu Ile Leu Arg Asn Leu 
        915                 920                 925             


Tyr His Glu Asn Ile Val Lys Tyr Lys Gly Ile Cys Thr Glu Asp Gly 
    930                 935                 940                 


Gly Asn Gly Ile Lys Leu Ile Met Glu Phe Leu Pro Ser Gly Ser Leu 
945                 950                 955                 960 


Lys Glu Tyr Leu Pro Lys Asn Lys Asn Lys Ile Asn Leu Lys Gln Gln 
                965                 970                 975     


Leu Lys Tyr Ala Val Gln Ile Cys Lys Gly Met Asp Tyr Leu Gly Ser 
            980                 985                 990         


Arg Gln Tyr Val His Arg Asp Leu  Ala Ala Arg Asn Val  Leu Val Glu 
        995                 1000                 1005             


Ser Glu  His Gln Val Lys Ile  Gly Asp Phe Gly Leu  Thr Lys Ala 
    1010                 1015                 1020             


Ile Glu  Thr Asp Lys Glu Tyr  Tyr Thr Val Lys Asp  Asp Arg Asp 
    1025                 1030                 1035             


Ser Pro  Val Phe Trp Tyr Ala  Pro Glu Cys Leu Met  Gln Ser Lys 
    1040                 1045                 1050             


Phe Tyr  Ile Ala Ser Asp Val  Trp Ser Phe Gly Val  Thr Leu His 
    1055                 1060                 1065             


Glu Leu  Leu Thr Tyr Cys Asp  Ser Asp Ser Ser Pro  Met Ala Leu 
    1070                 1075                 1080             


Phe Leu  Lys Met Ile Gly Pro  Thr His Gly Gln Met  Thr Val Thr 
    1085                 1090                 1095             


Arg Leu  Thr Leu Lys Glu Gly  Lys Arg Leu Pro Cys  Pro Pro Asn 
    1100                 1105                 1110             


Cys Pro  Asp Glu Val Tyr Gln  Leu Met Arg Lys Cys  Trp Glu Phe 
    1115                 1120                 1125             


Gln Pro  Ser Asn Arg Thr Ser  Phe Gln Asn Leu Ile  Glu Gly Phe 
    1130                 1135                 1140             


Glu Ala  Leu Leu Lys 
    1145             


<210>  2
<211>  1129
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Met Ala Cys Leu Thr Met Thr Glu Met Glu Gly Thr Ser Thr 
1               5                   10                  15      


Ser Ser Ile Tyr Gln Asn Gly Asp Ile Ser Gly Asn Ala Asn Ser Met 
            20                  25                  30          


Lys Gln Ile Asp Pro Val Leu Gln Val Tyr Leu Tyr His Ser Leu Gly 
        35                  40                  45              


Lys Ser Glu Ala Asp Tyr Leu Thr Phe Pro Ser Gly Glu Tyr Val Ala 
    50                  55                  60                  


Glu Glu Ile Cys Ile Ala Ala Ser Lys Ala Cys Gly Ile Thr Pro Val 
65                  70                  75                  80  


Tyr His Asn Met Phe Ala Leu Met Ser Glu Thr Glu Arg Ile Trp Tyr 
                85                  90                  95      


Pro Pro Asn His Val Phe His Ile Asp Glu Ser Thr Arg His Asn Val 
            100                 105                 110         


Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Arg Trp Tyr Cys Ser Gly Ser 
        115                 120                 125             


Asn Arg Ala Tyr Arg His Gly Ile Ser Arg Gly Ala Glu Ala Pro Leu 
    130                 135                 140                 


Leu Asp Asp Phe Val Met Ser Tyr Leu Phe Ala Gln Trp Arg His Asp 
145                 150                 155                 160 


Phe Val His Gly Trp Ile Lys Val Pro Val Thr His Glu Thr Gln Glu 
                165                 170                 175     


Glu Cys Leu Gly Met Ala Val Leu Asp Met Met Arg Ile Ala Lys Glu 
            180                 185                 190         


Asn Asp Gln Thr Pro Leu Ala Ile Tyr Asn Ser Ile Ser Tyr Lys Thr 
        195                 200                 205             


Phe Leu Pro Lys Cys Ile Pro Ala Lys Ile Gln Asp Tyr His Ile Leu 
    210                 215                 220                 


Thr Arg Lys Arg Ile Arg Tyr Arg Phe Arg Arg Phe Ile Gln Gln Phe 
225                 230                 235                 240 


Ser Gln Cys Lys Ala Thr Ala Arg Asn Leu Lys Leu Lys Tyr Leu Ile 
                245                 250                 255     


Asn Leu Glu Thr Leu Gln Ser Ala Phe Tyr Thr Glu Lys Phe Glu Val 
            260                 265                 270         


Lys Glu Pro Gly Ser Gly Pro Ser Gly Glu Glu Ile Phe Ala Thr Ile 
        275                 280                 285             


Ile Ile Thr Gly Asn Gly Gly Ile Gln Trp Ser Arg Gly Lys His Lys 
    290                 295                 300                 


Glu Ser Glu Thr Leu Thr Glu Gln Asp Leu Gln Leu Tyr Cys Asp Phe 
305                 310                 315                 320 


Pro Asn Ile Ile Asp Val Ser Ile Lys Gln Ala Asn Gln Glu Gly Ser 
                325                 330                 335     


Asn Glu Ser Arg Trp Thr Ile His Lys Gln Asp Gly Lys Asn Leu Glu 
            340                 345                 350         


Ile Glu Leu Ser Ser Leu Arg Glu Ala Leu Ser Phe Val Ser Leu Ile 
        355                 360                 365             


Asp Gly Tyr Tyr Arg Leu Thr Ala Asp Ala His His Tyr Leu Cys Lys 
    370                 375                 380                 


Glu Val Ala Pro Pro Ala Val Leu Glu Asn Ile Gln Ser Asn Cys His 
385                 390                 395                 400 


Gly Pro Ile Ser Met Asp Phe Ala Ile Ser Lys Leu Lys Lys Ala Gly 
                405                 410                 415     


Asn Gln Thr Gly Leu Tyr Val Leu Arg Cys Ser Pro Lys Asp Phe Asn 
            420                 425                 430         


Lys Tyr Phe Leu Thr Phe Ala Val Glu Arg Glu Asn Val Ile Glu Tyr 
        435                 440                 445             


Lys His Cys Leu Ile Thr Lys Asn Glu Asn Glu Glu Tyr Asn Leu Ser 
    450                 455                 460                 


Gly Thr Lys Lys Asn Phe Ser Ser Leu Lys Asp Leu Leu Asn Cys Tyr 
465                 470                 475                 480 


Gln Met Glu Thr Val Arg Ser Asp Asn Ile Ile Phe Gln Phe Thr Lys 
                485                 490                 495     


Cys Cys Pro Pro Lys Pro Lys Asp Lys Ser Asn Leu Leu Val Phe Arg 
            500                 505                 510         


Thr Asn Gly Val Ser Asp Val Pro Thr Ser Pro Thr Leu Gln Arg Pro 
        515                 520                 525             


Thr His Met Asn Gln Met Val Phe His Lys Ile Arg Asn Glu Asp Leu 
    530                 535                 540                 


Ile Phe Asn Glu Ser Leu Gly Gln Gly Thr Phe Thr Lys Ile Phe Lys 
545                 550                 555                 560 


Gly Val Arg Arg Glu Val Gly Asp Tyr Gly Gln Leu His Glu Thr Glu 
                565                 570                 575     


Val Leu Leu Lys Val Leu Asp Lys Ala His Arg Asn Tyr Ser Glu Ser 
            580                 585                 590         


Phe Phe Glu Ala Ala Ser Met Met Ser Lys Leu Ser His Lys His Leu 
        595                 600                 605             


Val Leu Asn Tyr Gly Val Cys Val Cys Gly Asp Glu Asn Ile Leu Val 
    610                 615                 620                 


Gln Glu Phe Val Lys Phe Gly Ser Leu Asp Thr Tyr Leu Lys Lys Asn 
625                 630                 635                 640 


Lys Asn Cys Ile Asn Ile Leu Trp Lys Leu Glu Val Ala Lys Gln Leu 
                645                 650                 655     


Ala Trp Ala Met His Phe Leu Glu Glu Asn Thr Leu Ile His Gly Asn 
            660                 665                 670         


Val Cys Ala Lys Asn Ile Leu Leu Ile Arg Glu Glu Asp Arg Lys Thr 
        675                 680                 685             


Gly Asn Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Ile Ser Ile Thr 
    690                 695                 700                 


Val Leu Pro Lys Asp Ile Leu Gln Glu Arg Ile Pro Trp Val Pro Pro 
705                 710                 715                 720 


Glu Cys Ile Glu Asn Pro Lys Asn Leu Asn Leu Ala Thr Asp Lys Trp 
                725                 730                 735     


Ser Phe Gly Thr Thr Leu Trp Glu Ile Cys Ser Gly Gly Asp Lys Pro 
            740                 745                 750         


Leu Ser Ala Leu Asp Ser Gln Arg Lys Leu Gln Phe Tyr Glu Asp Arg 
        755                 760                 765             


His Gln Leu Pro Ala Pro Lys Trp Ala Glu Leu Ala Asn Leu Ile Asn 
    770                 775                 780                 


Asn Cys Met Asp Tyr Glu Pro Asp Phe Arg Pro Ser Phe Arg Ala Ile 
785                 790                 795                 800 


Ile Arg Asp Leu Asn Ser Leu Phe Thr Pro Asp Tyr Glu Leu Leu Thr 
                805                 810                 815     


Glu Asn Asp Met Leu Pro Asn Met Arg Ile Gly Ala Leu Gly Phe Ser 
            820                 825                 830         


Gly Ala Phe Glu Asp Arg Asp Pro Thr Gln Phe Glu Glu Arg His Leu 
        835                 840                 845             


Lys Phe Leu Gln Gln Leu Gly Lys Gly Asn Phe Gly Ser Val Glu Met 
    850                 855                 860                 


Cys Arg Tyr Asp Pro Leu Gln Asp Asn Thr Gly Glu Trp Ala Val Lys 
865                 870                 875                 880 


Lys Leu Gln His Ser Thr Glu Glu His Leu Arg Asp Phe Glu Arg Glu 
                885                 890                 895     


Ile Glu Ile Leu Lys Ser Leu Gln His Asp Asn Ile Val Lys Tyr Lys 
            900                 905                 910         


Gly Val Cys Tyr Ser Ala Gly Arg Arg Asn Leu Lys Leu Ile Met Glu 
        915                 920                 925             


Tyr Leu Pro Tyr Gly Ser Leu Arg Asp Tyr Leu Gln Lys His Lys Glu 
    930                 935                 940                 


Arg Ile Asp His Ile Lys Leu Leu Gln Tyr Thr Ser Gln Ile Cys Lys 
945                 950                 955                 960 


Gly Met Glu Tyr Leu Gly Thr Lys Arg Tyr Ile His Arg Asp Leu Ala 
                965                 970                 975     


Thr Arg Asn Ile Leu Val Glu Asn Glu Asn Arg Val Lys Ile Gly Asp 
            980                 985                 990         


Phe Gly Leu Thr Lys Val Leu Pro  Gln Asp Lys Glu Tyr  Tyr Lys Val 
        995                 1000                 1005             


Lys Glu  Pro Gly Glu Ser Pro  Ile Phe Trp Tyr Ala  Pro Glu Ser 
    1010                 1015                 1020             


Leu Thr  Glu Ser Lys Phe Ser  Val Ala Ser Asp Val  Trp Ser Phe 
    1025                 1030                 1035             


Gly Trp  Leu Tyr Glu Leu Phe  Thr Tyr Ile Glu Lys  Ser Lys Ser 
    1040                 1045                 1050             


Pro Pro  Ala Glu Phe Met Arg  Met Ile Gly Asn Asp  Lys Gln Gly 
    1055                 1060                 1065             


Gln Met  Ile Val Phe His Leu  Ile Glu Leu Leu Lys  Asn Asn Gly 
    1070                 1075                 1080             


Arg Leu  Pro Arg Pro Asp Gly  Cys Pro Asp Glu Ile  Tyr Met Ile 
    1085                 1090                 1095             


Met Thr  Glu Cys Trp Asn Asn  Asn Val Asn Gln Arg  Pro Ser Phe 
    1100                 1105                 1110             


Arg Asp  Leu Ala Leu Arg Val  Asp Gln Ile Arg Asp  Asn Met Ala 
    1115                 1120                 1125             


Gly 
    


<210>  3
<211>  1119
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Ala Pro Pro Ser Glu Glu Thr Pro Leu Ile Pro Gln Arg Ser Cys 
1               5                   10                  15      


Ser Leu Leu Ser Thr Glu Ala Gly Ala Leu His Val Leu Leu Pro Ala 
            20                  25                  30          


Arg Gly Pro Gly Pro Pro Gln Arg Leu Ser Phe Ser Phe Gly Asp His 
        35                  40                  45              


Leu Ala Glu Asp Leu Cys Val Gln Ala Ala Lys Ala Ser Gly Ile Leu 
    50                  55                  60                  


Pro Val Tyr His Ser Leu Phe Ala Leu Ala Thr Glu Asp Leu Ser Cys 
65                  70                  75                  80  


Trp Phe Pro Pro Ser His Ile Phe Ser Val Glu Asp Ala Ser Thr Gln 
                85                  90                  95      


Val Leu Leu Tyr Arg Ile Arg Phe Tyr Phe Pro Asn Trp Phe Gly Leu 
            100                 105                 110         


Glu Lys Cys His Arg Phe Gly Leu Arg Lys Asp Leu Ala Ser Ala Ile 
        115                 120                 125             


Leu Asp Leu Pro Val Leu Glu His Leu Phe Ala Gln His Arg Ser Asp 
    130                 135                 140                 


Leu Val Ser Gly Arg Leu Pro Val Gly Leu Ser Leu Lys Glu Gln Gly 
145                 150                 155                 160 


Glu Cys Leu Ser Leu Ala Val Leu Asp Leu Ala Arg Met Ala Arg Glu 
                165                 170                 175     


Gln Ala Gln Arg Pro Gly Glu Leu Leu Lys Thr Val Ser Tyr Lys Ala 
            180                 185                 190         


Cys Leu Pro Pro Ser Leu Arg Asp Leu Ile Gln Gly Leu Ser Phe Val 
        195                 200                 205             


Thr Arg Arg Arg Ile Arg Arg Thr Val Arg Arg Ala Leu Arg Arg Val 
    210                 215                 220                 


Ala Ala Cys Gln Ala Asp Arg His Ser Leu Met Ala Lys Tyr Ile Met 
225                 230                 235                 240 


Asp Leu Glu Arg Leu Asp Pro Ala Gly Ala Ala Glu Thr Phe His Val 
                245                 250                 255     


Gly Leu Pro Gly Ala Leu Gly Gly His Asp Gly Leu Gly Leu Leu Arg 
            260                 265                 270         


Val Ala Gly Asp Gly Gly Ile Ala Trp Thr Gln Gly Glu Gln Glu Val 
        275                 280                 285             


Leu Gln Pro Phe Cys Asp Phe Pro Glu Ile Val Asp Ile Ser Ile Lys 
    290                 295                 300                 


Gln Ala Pro Arg Val Gly Pro Ala Gly Glu His Arg Leu Val Thr Val 
305                 310                 315                 320 


Thr Arg Thr Asp Asn Gln Ile Leu Glu Ala Glu Phe Pro Gly Leu Pro 
                325                 330                 335     


Glu Ala Leu Ser Phe Val Ala Leu Val Asp Gly Tyr Phe Arg Leu Thr 
            340                 345                 350         


Thr Asp Ser Gln His Phe Phe Cys Lys Glu Val Ala Pro Pro Arg Leu 
        355                 360                 365             


Leu Glu Glu Val Ala Glu Gln Cys His Gly Pro Ile Thr Leu Asp Phe 
    370                 375                 380                 


Ala Ile Asn Lys Leu Lys Thr Gly Gly Ser Arg Pro Gly Ser Tyr Val 
385                 390                 395                 400 


Leu Arg Arg Ser Pro Gln Asp Phe Asp Ser Phe Leu Leu Thr Val Cys 
                405                 410                 415     


Val Gln Asn Pro Leu Gly Pro Asp Tyr Lys Gly Cys Leu Ile Arg Arg 
            420                 425                 430         


Ser Pro Thr Gly Thr Phe Leu Leu Val Gly Leu Ser Arg Pro His Ser 
        435                 440                 445             


Ser Leu Arg Glu Leu Leu Ala Thr Cys Trp Asp Gly Gly Leu His Val 
    450                 455                 460                 


Asp Gly Val Ala Val Thr Leu Thr Ser Cys Cys Ile Pro Arg Pro Lys 
465                 470                 475                 480 


Glu Lys Ser Asn Leu Ile Trp Gln Arg Gly His Ser Pro Pro Thr Ser 
                485                 490                 495     


Ser Leu Val Gln Pro Gln Ser Gln Tyr Gln Leu Ser Gln Met Thr Phe 
            500                 505                 510         


His Lys Ile Pro Ala Asp Ser Leu Glu Trp His Glu Asn Leu Gly His 
        515                 520                 525             


Gly Ser Phe Thr Lys Ile Tyr Arg Gly Cys Arg His Glu Trp Asp Gly 
    530                 535                 540                 


Glu Ala Arg Lys Thr Glu Val Leu Leu Lys Val Met Asp Ala Lys His 
545                 550                 555                 560 


Lys Asn Cys Met Glu Ser Phe Leu Glu Ala Ala Ser Leu Met Ser Gln 
                565                 570                 575     


Val Ser Tyr Arg His Leu Val Leu Leu His Gly Val Cys Met Ala Gly 
            580                 585                 590         


Asp Ser Thr Met Val Gln Glu Phe Val His Leu Gly Ala Ile Asp Met 
        595                 600                 605             


Tyr Leu Arg Lys Arg Gly His Leu Val Pro Ala Ser Trp Lys Leu Gln 
    610                 615                 620                 


Trp Lys Gln Leu Ala Tyr Ala Leu Asn Tyr Leu Glu Asp Lys Gly Leu 
625                 630                 635                 640 


Pro His Gly Asn Val Ser Ala Arg Lys Val Leu Leu Ala Arg Glu Gly 
                645                 650                 655     


Ala Asp Gly Ser Pro Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Ser 
            660                 665                 670         


Pro Ala Val Leu Ser Leu Glu Met Leu Thr Asp Arg Ile Pro Trp Val 
        675                 680                 685             


Ala Pro Glu Cys Leu Arg Glu Ala Gln Thr Leu Ser Leu Glu Ala Asp 
    690                 695                 700                 


Lys Trp Gly Phe Gly Ala Thr Val Trp Glu Val Phe Ser Gly Val Thr 
705                 710                 715                 720 


Met Pro Ile Ser Ala Leu Asp Pro Ala Lys Lys Leu Gln Phe Tyr Glu 
                725                 730                 735     


Asp Arg Gln Gln Leu Pro Ala Pro Lys Trp Thr Glu Leu Ala Leu Leu 
            740                 745                 750         


Ile Gln Gln Cys Met Ala Tyr Glu Pro Val Gln Arg Pro Ser Phe Arg 
        755                 760                 765             


Ala Val Ile Arg Asp Leu Asn Ser Leu Ile Ser Ser Asp Tyr Glu Leu 
    770                 775                 780                 


Leu Ser Asp Pro Thr Pro Gly Ala Leu Ala Pro Arg Asp Gly Leu Trp 
785                 790                 795                 800 


Asn Gly Ala Gln Leu Tyr Ala Cys Gln Asp Pro Thr Ile Phe Glu Glu 
                805                 810                 815     


Arg His Leu Lys Tyr Ile Ser Gln Leu Gly Lys Gly Asn Phe Gly Ser 
            820                 825                 830         


Val Glu Leu Cys Arg Tyr Asp Pro Leu Gly Asp Asn Thr Gly Ala Leu 
        835                 840                 845             


Val Ala Val Lys Gln Leu Gln His Ser Gly Pro Asp Gln Gln Arg Asp 
    850                 855                 860                 


Phe Gln Arg Glu Ile Gln Ile Leu Lys Ala Leu His Ser Asp Phe Ile 
865                 870                 875                 880 


Val Lys Tyr Arg Gly Val Ser Tyr Gly Pro Gly Arg Gln Ser Leu Arg 
                885                 890                 895     


Leu Val Met Glu Tyr Leu Pro Ser Gly Cys Leu Arg Asp Phe Leu Gln 
            900                 905                 910         


Arg His Arg Ala Arg Leu Asp Ala Ser Arg Leu Leu Leu Tyr Ser Ser 
        915                 920                 925             


Gln Ile Cys Lys Gly Met Glu Tyr Leu Gly Ser Arg Arg Cys Val His 
    930                 935                 940                 


Arg Asp Leu Ala Ala Arg Asn Ile Leu Val Glu Ser Glu Ala His Val 
945                 950                 955                 960 


Lys Ile Ala Asp Phe Gly Leu Ala Lys Leu Leu Pro Leu Asp Lys Asp 
                965                 970                 975     


Tyr Tyr Trp Arg Glu Pro Gly Gln Ser Pro Ile Phe Trp Tyr Ala Pro 
            980                 985                 990         


Glu Ser Leu Ser Asp Asn Ile Phe  Ser Arg Gln Ser Asp  Val Trp Ser 
        995                 1000                 1005             


Phe Gly  Trp Leu Tyr Glu Leu  Phe Thr Tyr Cys Asp  Lys Ser Cys 
    1010                 1015                 1020             


Ser Pro  Ser Ala Glu Phe Leu  Arg Met Met Gly Cys  Glu Arg Asp 
    1025                 1030                 1035             


Val Pro  Ala Leu Cys Arg Leu  Leu Glu Leu Leu Glu  Glu Gly Gln 
    1040                 1045                 1050             


Arg Leu  Pro Ala Pro Pro Ala  Cys Pro Ala Glu Val  His Glu Leu 
    1055                 1060                 1065             


Met Lys  Leu Cys Trp Ala Pro  Ser Pro Gln Asp Arg  Pro Ser Phe 
    1070                 1075                 1080             


Ser Ala  Leu Gly Pro Gln Leu  Asp Met Leu Trp Ser  Gly Ser Arg 
    1085                 1090                 1095             


Gly Cys  Glu Thr His Ala Phe  Thr Ala His Pro Glu  Gly Lys His 
    1100                 1105                 1110             


His Ser  Leu Ser Phe Ser 
    1115                 


