                               SEQUENCE LISTING

<110> NOVARTIS AG
 
<120> NKG2D FUSION PROTEINS AND USES THEREOF

<130> PAT058633-WO-PCT

<140>
<141>

<150> 62/902,080
<151> 2019-09-18

<150> 62/902,071
<151> 2019-09-18

<160> 76    

<170> PatentIn version 3.5

<210> 1
<211> 141
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 1
Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser 
    130                 135                 140     


<210> 2
<211> 135
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 2
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser 
    130                 135 


<210> 3
<211> 139
<212> PRT
<213> Mus musculus

<400> 3
Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
1               5                   10                  15      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        35                  40                  45              


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    50                  55                  60                  


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                85                  90                  95      


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            100                 105                 110         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        115                 120                 125             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
    130                 135                 


<210> 4
<211> 232
<212> PRT
<213> Mus musculus

<400> 4
Met Ala Leu Ile Arg Asp Arg Lys Ser His His Ser Glu Met Ser Lys 
1               5                   10                  15      


Cys His Asn Tyr Asp Leu Lys Pro Ala Lys Trp Asp Thr Ser Gln Glu 
            20                  25                  30          


Gln Gln Lys Gln Arg Leu Ala Leu Thr Thr Ser Gln Pro Gly Glu Asn 
        35                  40                  45              


Gly Ile Ile Arg Gly Arg Tyr Pro Ile Glu Lys Leu Lys Ile Ser Pro 
    50                  55                  60                  


Met Phe Val Val Arg Val Leu Ala Ile Ala Leu Ala Ile Arg Phe Thr 
65                  70                  75                  80  


Leu Asn Thr Leu Met Trp Leu Ala Ile Phe Lys Glu Thr Phe Gln Pro 
                85                  90                  95      


Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys 
            100                 105                 110         


Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln 
        115                 120                 125             


Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu 
    130                 135                 140                 


Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp 
145                 150                 155                 160 


Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile 
                165                 170                 175     


Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr 
            180                 185                 190         


Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr 
        195                 200                 205             


Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr 
    210                 215                 220                 


Tyr Ile Cys Met Lys Arg Ala Val 
225                 230         


<210> 5
<211> 227
<212> PRT
<213> Homo sapiens

<400> 5
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 6
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 6
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 7
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(24)
<223> /note="This sequence may encompass 1-12 'Gly Ser'
      repeating units"

<400> 7
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser Gly Ser Gly Ser 
            20                  


<210> 8
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(25)
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Gly Ser'
      repeating units"

<400> 8
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Ser'
      repeating units"

<400> 9
Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Gly Gly Gly Ser Gly Gly Gly Ser 
1               5               


<210> 11
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Gly Gly Gly Ser 
1               5   


<210> 12
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(25)
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Gly Ala'
      repeating units"

<400> 12
Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly Gly Gly Gly Ala Gly 
1               5                   10                  15      


Gly Gly Gly Ala Gly Gly Gly Gly Ala 
            20                  25  


<210> 13
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(25)
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Gly Pro'
      repeating units"

<400> 13
Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly 
1               5                   10                  15      


Gly Gly Gly Pro Gly Gly Gly Gly Pro 
            20                  25  


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> SITE
<222> (1)..(20)
<223> /note="This sequence may encompass 1-5 'Gly Gly Gly Ala'
      repeating units"

<400> 14
Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala Gly Gly Gly Ala 
1               5                   10                  15      


Gly Gly Gly Ala 
            20  


<210> 15
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 15
Gly Gly Pro Leu Gly Leu Trp Ala Gly Gly 
1               5                   10  


<210> 16
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 16
Ile Glu Gly Arg 
1               


<210> 17
<211> 366
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 17
Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Asp Lys Thr His Thr 
    130                 135                 140                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
145                 150                 155                 160 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                165                 170                 175     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            180                 185                 190         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        195                 200                 205             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    210                 215                 220                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
225                 230                 235                 240 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                245                 250                 255     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            260                 265                 270         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        275                 280                 285             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    290                 295                 300                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
305                 310                 315                 320 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                325                 330                 335     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            340                 345                 350         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360                 365     


<210> 18
<211> 1098
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 18
ttcctgaact ccctgttcaa ccaggaagtg cagatccccc tgaccgagag ctactgcggc       60

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc      120

aagaattggt acgagagcca ggccagctgc atgagccaga acgccagcct gctgaaggtg      180

tacagcaaag aggaccagga tctgctgaag ctcgtgaagt cctaccactg gatgggcctg      240

gtgcacatcc ccaccaatgg cagctggcag tgggaggacg gcagcatcct gagccccaac      300

ctgctgacca tcatcgagat gcagaagggc gactgcgccc tgtacgccag cagcttcaag      360

ggctacatcg agaactgcag cacccccaac acctacatct gtatgcagcg gaccgtcgac      420

aagacccaca cctgcccccc ctgtcctgcc cctgaactgc tgggcggacc ctccgtgttc      480

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc      540

gtggtggtgg acgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc      600

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtacaacag cacctaccgg      660

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc      720

aaagtctcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc      780

cagccccgcg agccccaggt gtacacactg ccccccagcc gggacgagct gaccaagaac      840

caggtgtccc tgacctgcct ggtcaagggc ttctacccca gcgatatcgc cgtggaatgg      900

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac      960

ggctcattct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1020

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1080

agcctgagcc ccggcaaa                                                   1098


<210> 19
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 19
Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln 
145                 150                 155                 160 


Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile 
                165                 170                 175     


Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp 
            180                 185                 190         


Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys 
        195                 200                 205             


Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met 
                245                 250                 255     


Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile 
            260                 265                 270         


Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210> 20
<211> 1545
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 20
ttcctgaact ccctgttcaa ccaggaagtg cagatccccc tgaccgagag ctactgcggc       60

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc      120

aagaattggt acgagagcca ggccagctgc atgagccaga acgccagcct gctgaaggtg      180

tacagcaaag aggaccagga tctgctgaag ctcgtgaagt cctaccactg gatgggcctg      240

gtgcacatcc ccaccaatgg cagctggcag tgggaggacg gcagcatcct gagccccaac      300

ctgctgacca tcatcgagat gcagaagggc gactgcgccc tgtacgccag cagcttcaag      360

ggctacatcg agaactgcag cacccccaac acctacatct gtatgcagcg gaccgtcaga      420

agtggaggcg ggtctggagg cggatccttt ctgaatagcc tgtttaacca ggaagtgcag      480

atccccctga ccgagagcta ctgcggcccc tgccccaaga actggatctg ctacaagaac      540

aactgctacc agttcttcga cgagagcaag aattggtacg agagccaggc cagctgcatg      600

agccagaacg ccagcctgct gaaggtgtac agcaaagagg accaggatct gctgaagctc      660

gtgaagtcct accactggat gggcctggtg cacatcccca ccaatggcag ctggcagtgg      720

gaggacggca gcatcctgag ccccaacctg ctgaccatca tcgagatgca gaagggcgac      780

tgcgccctgt acgccagcag cttcaagggc tacatcgaga actgcagcac ccccaacacc      840

tacatttgca tgcagcgtac ggttgacaag acccacacct gccccccctg tcctgcccct      900

gaactgctgg gcggaccctc cgtgttcctg ttccccccaa agcccaagga caccctgatg      960

atcagccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggaccctgaa     1020

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga     1080

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac     1140

tggctgaacg gcaaagagta caagtgcaaa gtctccaaca aggccctgcc tgcccccatc     1200

gagaaaacca tcagcaaggc caagggccag ccccgcgagc cccaggtgta cacactgccc     1260

cccagccggg acgagctgac caagaaccag gtgtccctga cctgcctggt caagggcttc     1320

taccccagcg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1380

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtacagcaa gctgaccgtg     1440

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1500

cacaaccact acacccagaa gtccctgagc ctgagccccg gcaaa                     1545


<210> 21
<211> 365
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 21
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu 
225                 230                 235                 240 


Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys 
                245                 250                 255     


Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser 
            260                 265                 270         


Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser 
        275                 280                 285             


Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met 
    290                 295                 300                 


Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly 
                325                 330                 335     


Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys 
            340                 345                 350         


Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        355                 360                 365 


<210> 22
<211> 1095
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 22
gacaagaccc acacctgtcc tccctgtcct gcccctgaac tgctgggcgg acctagcgtg       60

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      120

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      180

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      240

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      300

tgcaaggtgt ccaacaaggc cctgccagcc cccatcgaga aaaccatcag caaggccaag      360

ggccagcccc gcgaacccca ggtgtacaca ctgcccccta gccgggaaga gatgaccaag      420

aaccaggtgt ccctgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa      480

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc      540

gacggctcat tcttcctgta cagcaagctg acagtggaca agagccggtg gcagcagggc      600

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc      660

ttaagcctga gccctggctt cctgaactcc ctgttcaacc aggaagtgca gatccccctg      720

accgagagct actgcggccc ctgccccaag aactggatct gctacaagaa caactgctac      780

cagttcttcg acgagagcaa gaattggtac gagagccagg ccagctgcat gagccagaac      840

gccagcctgc tgaaggtgta cagcaaagag gaccaggatc tgctgaagct cgtgaagtcc      900

taccactgga tgggcctggt gcacatcccc accaatggca gctggcagtg ggaggacggc      960

agcatcctga gccccaacct gctgaccatc atcgagatgc agaagggcga ctgcgccctg     1020

tacgccagca gcttcaaggg ctacatcgag aactgcagca cccccaacac ctacatctgt     1080

atgcagcgga ccgtc                                                      1095


<210> 23
<211> 514
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 23
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu 
225                 230                 235                 240 


Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys 
                245                 250                 255     


Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser 
            260                 265                 270         


Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser 
        275                 280                 285             


Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met 
    290                 295                 300                 


Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly 
305                 310                 315                 320 


Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly 
                325                 330                 335     


Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys 
            340                 345                 350         


Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu 
    370                 375                 380                 


Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn 
385                 390                 395                 400 


Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys 
                405                 410                 415     


Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu 
            420                 425                 430         


Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys 
        435                 440                 445             


Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp 
    450                 455                 460                 


Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile 
465                 470                 475                 480 


Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly 
                485                 490                 495     


Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg 
            500                 505                 510         


Thr Val 
        


<210> 24
<211> 1542
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 24
gacaagaccc acacctgtcc tccctgtcct gcccctgaac tgctgggcgg acctagcgtg       60

ttcctgttcc ccccaaagcc caaggacacc ctgatgatca gccggacccc cgaagtgacc      120

tgcgtggtgg tggatgtgtc ccacgaggac cctgaagtga agttcaattg gtacgtggac      180

ggcgtggaag tgcacaacgc caagaccaag cccagagagg aacagtacaa cagcacctac      240

cgggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa agagtacaag      300

tgcaaggtgt ccaacaaggc cctgccagcc cccatcgaga aaaccatcag caaggccaag      360

ggccagcccc gcgaacccca ggtgtacaca ctgcccccta gccgggaaga gatgaccaag      420

aaccaggtgt ccctgacctg tctcgtgaag ggcttctacc cctccgatat cgccgtggaa      480

tgggagagca acggccagcc cgagaacaac tacaagacca ccccccctgt gctggacagc      540

gacggctcat tcttcctgta cagcaagctg acagtggaca agagccggtg gcagcagggc      600

aacgtgttca gctgcagcgt gatgcacgag gccctgcaca accactacac ccagaagagc      660

ttaagcctga gccctggctt cctgaactcc ctgttcaacc aggaagtgca gatccccctg      720

accgagagct actgcggccc ctgccccaag aactggatct gctacaagaa caactgctac      780

cagttcttcg acgagagcaa gaattggtac gagagccagg ccagctgcat gagccagaac      840

gccagcctgc tgaaggtgta cagcaaagag gaccaggatc tgctgaagct cgtgaagtcc      900

taccactgga tgggcctggt gcacatcccc accaatggca gctggcagtg ggaggacggc      960

agcatcctga gccccaacct gctgaccatc atcgagatgc agaagggcga ctgcgccctg     1020

tacgccagca gcttcaaggg ctacatcgag aactgcagca cccccaacac ctacatctgt     1080

atgcagcgga ccgtcagaag tggaggcggg tctggaggcg gatcctttct gaatagcctg     1140

tttaaccagg aagtgcagat ccccctgacc gagagctact gcggcccctg ccccaagaac     1200

tggatctgct acaagaacaa ctgctaccag ttcttcgacg agagcaagaa ttggtacgag     1260

agccaggcca gctgcatgag ccagaacgcc agcctgctga aggtgtacag caaagaggac     1320

caggatctgc tgaagctcgt gaagtcctac cactggatgg gcctggtgca catccccacc     1380

aatggcagct ggcagtggga ggacggcagc atcctgagcc ccaacctgct gaccatcatc     1440

gagatgcaga agggcgactg cgccctgtac gccagcagct tcaagggcta catcgagaac     1500

tgcagcaccc ccaacaccta catttgcatg cagcgtacgg tt                        1542


<210> 25
<211> 515
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 25
Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln 
145                 150                 155                 160 


Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile 
                165                 170                 175     


Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp 
            180                 185                 190         


Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys 
        195                 200                 205             


Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met 
                245                 250                 255     


Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile 
            260                 265                 270         


Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
        275                 280                 285             


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
    290                 295                 300                 


Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
305                 310                 315                 320 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
                325                 330                 335     


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
            340                 345                 350         


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
        355                 360                 365             


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
    370                 375                 380                 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Glu 
385                 390                 395                 400 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
                405                 410                 415     


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
            420                 425                 430         


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
        435                 440                 445             


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
    450                 455                 460                 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
465                 470                 475                 480 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
                485                 490                 495     


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
            500                 505                 510         


Pro Gly Lys 
        515 


<210> 26
<211> 1545
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 26
ttcctgaact ccctgttcaa ccaggaagtg cagatccccc tgaccgagag ctactgcggc       60

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc      120

aagaattggt acgagagcca ggccagctgc atgagccaga acgccagcct gctgaaggtg      180

tacagcaaag aggaccagga tctgctgaag ctcgtgaagt cctaccactg gatgggcctg      240

gtgcacatcc ccaccaatgg cagctggcag tgggaggacg gcagcatcct gagccccaac      300

ctgctgacca tcatcgagat gcagaagggc gactgcgccc tgtacgccag cagcttcaag      360

ggctacatcg agaactgcag cacccccaac acctacatct gtatgcagcg gaccgtcaga      420

agtggaggcg ggtctggagg cggatccttt ctgaatagcc tgtttaacca ggaagtgcag      480

atccccctga ccgagagcta ctgcggcccc tgccccaaga actggatctg ctacaagaac      540

aactgctacc agttcttcga cgagagcaag aattggtacg agagccaggc cagctgcatg      600

agccagaacg ccagcctgct gaaggtgtac agcaaagagg accaggatct gctgaagctc      660

gtgaagtcct accactggat gggcctggtg cacatcccca ccaatggcag ctggcagtgg      720

gaggacggca gcatcctgag ccccaacctg ctgaccatca tcgagatgca gaagggcgac      780

tgcgccctgt acgccagcag cttcaagggc tacatcgaga actgcagcac ccccaacacc      840

tacatttgca tgcagcgtac ggttgacaag acccacacct gccccccctg tcctgcccct      900

gaactgctgg gcggacccga cgtgttcctg ttccccccaa agcccaagga caccctgatg      960

atcagccgga cccccgaagt gacctgcgtg gtggtggacg tgtcccacga ggaccctgaa     1020

gtgaagttca attggtacgt ggacggcgtg gaagtgcaca acgccaagac caagcccaga     1080

gaggaacagt acaacagcac ctaccgggtg gtgtccgtgc tgaccgtgct gcaccaggac     1140

tggctgaacg gcaaagagta caagtgcaaa gtctccaaca aggccctgcc tgcccccgaa     1200

gagaaaacca tcagcaaggc caagggccag ccccgcgagc cccaggtgta cacactgccc     1260

cccagccggg acgagctgac caagaaccag gtgtccctga cctgcctggt caagggcttc     1320

taccccagcg atatcgccgt ggaatgggag agcaacggcc agcccgagaa caactacaag     1380

accacccccc ctgtgctgga cagcgacggc tcattcttcc tgtacagcaa gctgaccgtg     1440

gacaagtccc ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg     1500

cacaaccact acacccagaa gtccctgagc ctgagccccg gcaaa                     1545


<210> 27
<211> 509
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 27
Phe Leu Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
1               5                   10                  15      


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        35                  40                  45              


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    50                  55                  60                  


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                85                  90                  95      


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            100                 105                 110         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        115                 120                 125             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser 
145                 150                 155                 160 


Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys 
                165                 170                 175     


Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser 
            180                 185                 190         


Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp 
        195                 200                 205             


Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val 
    210                 215                 220                 


His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu 
225                 230                 235                 240 


Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala 
                245                 250                 255     


Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro 
            260                 265                 270         


Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Asp Lys Thr His Thr Cys 
        275                 280                 285             


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
    290                 295                 300                 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
305                 310                 315                 320 


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
                325                 330                 335     


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
            340                 345                 350         


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
        355                 360                 365             


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
    370                 375                 380                 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
385                 390                 395                 400 


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
                405                 410                 415     


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
            420                 425                 430         


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
        435                 440                 445             


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
    450                 455                 460                 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
465                 470                 475                 480 


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
                485                 490                 495     


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            500                 505                 


<210> 28
<211> 1527
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 28
ttcctgaact ccctgttcaa ccaggaagtg cagatccccc tgaccgagag ctactgcggc       60

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc      120

aagaattggt acgagagcca ggccagctgc atgagccaga acgccagcct gctgaaggtg      180

tacagcaaag aggaccagga tctgctgaag ctcgtgaagt cctaccactg gatgggcctg      240

gtgcacatcc ccaccaatgg cagctggcag tgggaggacg gcagcatcct gagccccaac      300

ctgctgacca tcatcgagat gcagaagggc gactgcgccc tgtacgccag cagcttcaag      360

ggctacatcg agaactgcag cacccccaac acctacatct gtatgcagcg gaccgtcaga      420

agtggaggcg ggtctggagg cggatccaac caggaagtgc agatccccct gaccgagagc      480

tactgcggcc cctgccccaa gaactggatc tgctacaaga acaactgcta ccagttcttc      540

gacgagagca agaattggta cgagagccag gccagctgca tgagccagaa cgccagcctg      600

ctgaaggtgt acagcaaaga ggaccaggat ctgctgaagc tcgtgaagtc ctaccactgg      660

atgggcctgg tgcacatccc caccaatggc agctggcagt gggaggacgg cagcatcctg      720

agccccaacc tgctgaccat catcgagatg cagaagggcg actgcgccct gtacgccagc      780

agcttcaagg gctacatcga gaactgcagc acccccaaca cctacatttg catgcagcgt      840

acggttgaca agacccacac ctgccccccc tgtcctgccc ctgaactgct gggcggaccc      900

tccgtgttcc tgttcccccc aaagcccaag gacaccctga tgatcagccg gacccccgaa      960

gtgacctgcg tggtggtgga cgtgtcccac gaggaccctg aagtgaagtt caattggtac     1020

gtggacggcg tggaagtgca caacgccaag accaagccca gagaggaaca gtacaacagc     1080

acctaccggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaagag     1140

tacaagtgca aagtctccaa caaggccctg cctgccccca tcgagaaaac catcagcaag     1200

gccaagggcc agccccgcga gccccaggtg tacacactgc cccccagccg ggacgagctg     1260

accaagaacc aggtgtccct gacctgcctg gtcaagggct tctaccccag cgatatcgcc     1320

gtggaatggg agagcaacgg ccagcccgag aacaactaca agaccacccc ccctgtgctg     1380

gacagcgacg gctcattctt cctgtacagc aagctgaccg tggacaagtc ccggtggcag     1440

cagggcaacg tgttcagctg cagcgtgatg cacgaggccc tgcacaacca ctacacccag     1500

aagtccctga gcctgagccc cggcaaa                                         1527


<210> 29
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 29
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210> 30
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 30
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttga caagacccac      840

acctgccccc cctgtcctgc ccctgaactg ctgggcggac cctccgtgtt cctgttcccc      900

ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg      960

gacgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg     1020

cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc     1080

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1140

aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagccccgc     1200

gagccccagg tgtacacact gccccccagc cgggacgagc tgaccaagaa ccaggtgtcc     1260

ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac     1320

ggccagcccg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc     1380

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1440

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc     1500

cccggcaaa                                                             1509


<210> 31
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 31
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Asp Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Glu Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210> 32
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 32
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgc      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttga caagacccac      840

acctgccccc cctgtcctgc ccctgaactg ctgggcggac ccgacgtgtt cctgttcccc      900

ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg      960

gacgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg     1020

cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc     1080

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1140

aacaaggccc tgcctgcccc cgaagagaaa accatcagca aggccaaggg ccagccccgc     1200

gagccccagg tgtacacact gccccccagc cgggacgagc tgaccaagaa ccaggtgtcc     1260

ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac     1320

ggccagcccg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc     1380

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1440

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc     1500

cccggcaaa                                                             1509


<210> 33
<211> 606
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 33
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        275                 280                 285             


Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu 
    290                 295                 300                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
305                 310                 315                 320 


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
                325                 330                 335     


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
            340                 345                 350         


Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr 
        355                 360                 365             


Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
    370                 375                 380                 


Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 
385                 390                 395                 400 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                405                 410                 415     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            420                 425                 430         


Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        435                 440                 445             


Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val 
    450                 455                 460                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
465                 470                 475                 480 


Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                485                 490                 495     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            500                 505                 510         


Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        515                 520                 525             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    530                 535                 540                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
545                 550                 555                 560 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                565                 570                 575     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            580                 585                 590         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        595                 600                 605     


<210> 34
<211> 1818
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 34
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttgc tagcaccaag      840

ggccccagcg tgttccccct ggcgcccagc agcaagagca ccagcggcgg cacagccgcc      900

ctgggctgcc tggtgaagga ctacttcccc gagccagtga ccgtgtcctg gaacagcgga      960

gccctgacct ccggcgtgca caccttcccc gccgtgctgc agagcagcgg cctgtacagc     1020

ctgagcagcg tggtgaccgt gcccagcagc agcctgggca cccagaccta catctgcaac     1080

gtgaaccaca agcccagcaa caccaaggtg gacaagagag tggagcccaa gagctgcgac     1140

aagacccaca cctgcccccc ctgtcctgcc cctgaactgc tgggcggacc ctccgtgttc     1200

ctgttccccc caaagcccaa ggacaccctg atgatcagcc ggacccccga agtgacctgc     1260

gtggtggtgg acgtgtccca cgaggaccct gaagtgaagt tcaattggta cgtggacggc     1320

gtggaagtgc acaacgccaa gaccaagccc agagaggaac agtacaacag cacctaccgg     1380

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgc     1440

aaagtctcca acaaggccct gcctgccccc atcgagaaaa ccatcagcaa ggccaagggc     1500

cagccccgcg agccccaggt gtacacactg ccccccagcc gggacgagct gaccaagaac     1560

caggtgtccc tgacctgcct ggtcaagggc ttctacccca gcgatatcgc cgtggaatgg     1620

gagagcaacg gccagcccga gaacaactac aagaccaccc cccctgtgct ggacagcgac     1680

ggctcattct tcctgtacag caagctgacc gtggacaagt cccggtggca gcagggcaac     1740

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagtccctg     1800

agcctgagcc ccggcaaa                                                   1818


<210> 35
<211> 383
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 35
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
        275                 280                 285             


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
    290                 295                 300                 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
305                 310                 315                 320 


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
                325                 330                 335     


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
            340                 345                 350         


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
        355                 360                 365             


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    370                 375                 380             


<210> 36
<211> 1149
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 36
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttcg gacagtggcc      840

gctcctagcg tgttcatctt tccaccaagc gacgagcagc tgaagtctgg cacagcctct      900

gtcgtgtgcc tgctgaacaa cttctacccc agagaagcca aggtgcagtg gaaggtggac      960

aatgccctgc agagcggcaa tagccaagag agcgtgaccg agcaggacag caaggatagc     1020

acatacagcc tgagcagcac cctgactctg agcaaggccg actacgagaa gcacaaagtg     1080

tacgcctgcg aagtgacaca ccagggcctg tctagccctg tgaccaagag cttcaacaga     1140

ggcgagtgc                                                             1149


<210> 37
<211> 463
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 37
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
    130                 135                 140                 


Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
145                 150                 155                 160 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
                165                 170                 175     


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
            180                 185                 190         


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
        195                 200                 205             


Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
    210                 215                 220                 


Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 
225                 230                 235                 240 


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            260                 265                 270         


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        275                 280                 285             


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    290                 295                 300                 


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
305                 310                 315                 320 


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                325                 330                 335     


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            340                 345                 350         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        355                 360                 365             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    370                 375                 380                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
385                 390                 395                 400 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            420                 425                 430         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        435                 440                 445             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460             


<210> 38
<211> 1389
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 38
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgc      360

agcaccccca acacctacat ttgcatgcag cgtacggttg ctagcaccaa gggccccagc      420

gtgttccccc tggcgcccag cagcaagagc accagcggcg gcacagccgc cctgggctgc      480

ctggtgaagg actacttccc cgagccagtg accgtgtcct ggaacagcgg agccctgacc      540

tccggcgtgc acaccttccc cgccgtgctg cagagcagcg gcctgtacag cctgagcagc      600

gtggtgaccg tgcccagcag cagcctgggc acccagacct acatctgcaa cgtgaaccac      660

aagcccagca acaccaaggt ggacaagaga gtggagccca agagctgcga caagacccac      720

acctgccccc cctgtcctgc ccctgaactg ctgggcggac cctccgtgtt cctgttcccc      780

ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg      840

gacgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg      900

cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc      960

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1020

aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagccccgc     1080

gagccccagg tgtacacact gccccccagc cgggacgagc tgaccaagaa ccaggtgtcc     1140

ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac     1200

ggccagcccg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc     1260

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1320

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc     1380

cccggcaaa                                                             1389


<210> 39
<211> 240
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 39
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe 
    130                 135                 140                 


Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys 
145                 150                 155                 160 


Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val 
                165                 170                 175     


Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln 
            180                 185                 190         


Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser 
        195                 200                 205             


Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His 
    210                 215                 220                 


Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 240 


<210> 40
<211> 720
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 40
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgc      360

agcaccccca acacctacat ttgcatgcag cgtacggttc ggacagtggc cgctcctagc      420

gtgttcatct ttccaccaag cgacgagcag ctgaagtctg gcacagcctc tgtcgtgtgc      480

ctgctgaaca acttctaccc cagagaagcc aaggtgcagt ggaaggtgga caatgccctg      540

cagagcggca atagccaaga gagcgtgacc gagcaggaca gcaaggatag cacatacagc      600

ctgagcagca ccctgactct gagcaaggcc gactacgaga agcacaaagt gtacgcctgc      660

gaagtgacac accagggcct gtctagccct gtgaccaaga gcttcaacag aggcgagtgc      720


<210> 41
<211> 360
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 41
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
    130                 135                 140                 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
145                 150                 155                 160 


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
                165                 170                 175     


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
            180                 185                 190         


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
        195                 200                 205             


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
    210                 215                 220                 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
225                 230                 235                 240 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
                245                 250                 255     


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
            260                 265                 270         


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
        275                 280                 285             


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
    290                 295                 300                 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
305                 310                 315                 320 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
                325                 330                 335     


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
            340                 345                 350         


Ser Leu Ser Leu Ser Pro Gly Lys 
        355                 360 


<210> 42
<211> 1080
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 42
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgc      360

agcaccccca acacctacat ctgtatgcag cggaccgtcg acaagaccca cacctgcccc      420

ccctgtcctg cccctgaact gctgggcgga ccctccgtgt tcctgttccc cccaaagccc      480

aaggacaccc tgatgatcag ccggaccccc gaagtgacct gcgtggtggt ggacgtgtcc      540

cacgaggacc ctgaagtgaa gttcaattgg tacgtggacg gcgtggaagt gcacaacgcc      600

aagaccaagc ccagagagga acagtacaac agcacctacc gggtggtgtc cgtgctgacc      660

gtgctgcacc aggactggct gaacggcaaa gagtacaagt gcaaagtctc caacaaggcc      720

ctgcctgccc ccatcgagaa aaccatcagc aaggccaagg gccagccccg cgagccccag      780

gtgtacacac tgccccccag ccgggacgag ctgaccaaga accaggtgtc cctgacctgc      840

ctggtcaagg gcttctaccc cagcgatatc gccgtggaat gggagagcaa cggccagccc      900

gagaacaact acaagaccac cccccctgtg ctggacagcg acggctcatt cttcctgtac      960

agcaagctga ccgtggacaa gtcccggtgg cagcagggca acgtgttcag ctgcagcgtg     1020

atgcacgagg ccctgcacaa ccactacacc cagaagtccc tgagcctgag ccccggcaaa     1080


<210> 43
<211> 779
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 43
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys Asn Gln Glu Val Gln Ile Pro Leu Thr 
            500                 505                 510         


Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn 
        515                 520                 525             


Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln 
    530                 535                 540                 


Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys 
545                 550                 555                 560 


Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly 
                565                 570                 575     


Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser 
            580                 585                 590         


Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp 
        595                 600                 605             


Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser 
    610                 615                 620                 


Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser Gly Gly 
625                 630                 635                 640 


Gly Ser Gly Gly Gly Ser Asn Gln Glu Val Gln Ile Pro Leu Thr Glu 
                645                 650                 655     


Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn 
            660                 665                 670         


Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala 
        675                 680                 685             


Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu 
    690                 695                 700                 


Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
705                 710                 715                 720 


Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile 
                725                 730                 735     


Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly Asp Cys 
            740                 745                 750         


Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr 
        755                 760                 765             


Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val 
    770                 775                 


<210> 44
<211> 2337
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 44
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttga caagacccac      840

acctgccccc cctgtcctgc ccctgaactg ctgggcggac cctccgtgtt cctgttcccc      900

ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg cgtggtggtg      960

gacgtgtccc acgaggaccc tgaagtgaag ttcaattggt acgtggacgg cgtggaagtg     1020

cacaacgcca agaccaagcc cagagaggaa cagtacaaca gcacctaccg ggtggtgtcc     1080

gtgctgaccg tgctgcacca ggactggctg aacggcaaag agtacaagtg caaagtctcc     1140

aacaaggccc tgcctgcccc catcgagaaa accatcagca aggccaaggg ccagccccgc     1200

gagccccagg tgtacacact gccccccagc cgggacgagc tgaccaagaa ccaggtgtcc     1260

ctgacctgcc tggtcaaggg cttctacccc agcgatatcg ccgtggaatg ggagagcaac     1320

ggccagcccg agaacaacta caagaccacc ccccctgtgc tggacagcga cggctcattc     1380

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1440

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc     1500

cccggcaaaa accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc     1560

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg     1620

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa     1680

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc     1740

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc     1800

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc     1860

gagaactgta gcacccccaa cacctacatc tgtatgcagc ggaccgtcag aagtggaggc     1920

gggtctggag gcggatccaa ccaggaagtg cagatccccc tgaccgagag ctactgcggc     1980

ccctgcccca agaactggat ctgctacaag aacaactgct accagttctt cgacgagagc     2040

aagaattggt acgagagcca ggccagctgc atgagccaga acgccagcct gctgaaggtg     2100

tacagcaaag aggaccagga tctgctgaag ctcgtgaagt cctaccactg gatgggcctg     2160

gtgcacatcc ccaccaatgg cagctggcag tgggaggacg gcagcatcct gagccccaac     2220

ctgctgacca tcatcgagat gcagaagggc gactgcgccc tgtacgccag cagcttcaag     2280

ggctacatcg agaactgcag cacccccaac acctacattt gcatgcagcg tacggtt        2337


<210> 45
<211> 784
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Arg Ser Gly Gly Gly Asn Gln Glu Val Gln Ile Pro 
        275                 280                 285             


Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr 
    290                 295                 300                 


Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu 
305                 310                 315                 320 


Ser Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr 
                325                 330                 335     


Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp 
            340                 345                 350         


Met Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp 
        355                 360                 365             


Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys 
    370                 375                 380                 


Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn 
385                 390                 395                 400 


Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Arg Ser 
                405                 410                 415     


Gly Gly Gly Ser Gly Gly Gly Ser Asn Gln Glu Val Gln Ile Pro Leu 
            420                 425                 430         


Thr Glu Ser Tyr Cys Gly Pro Cys Pro Lys Asn Trp Ile Cys Tyr Lys 
        435                 440                 445             


Asn Asn Cys Tyr Gln Phe Phe Asp Glu Ser Lys Asn Trp Tyr Glu Ser 
    450                 455                 460                 


Gln Ala Ser Cys Met Ser Gln Asn Ala Ser Leu Leu Lys Val Tyr Ser 
465                 470                 475                 480 


Lys Glu Asp Gln Asp Leu Leu Lys Leu Val Lys Ser Tyr His Trp Met 
                485                 490                 495     


Gly Leu Val His Ile Pro Thr Asn Gly Ser Trp Gln Trp Glu Asp Gly 
            500                 505                 510         


Ser Ile Leu Ser Pro Asn Leu Leu Thr Ile Ile Glu Met Gln Lys Gly 
        515                 520                 525             


Asp Cys Ala Leu Tyr Ala Ser Ser Phe Lys Gly Tyr Ile Glu Asn Cys 
    530                 535                 540                 


Ser Thr Pro Asn Thr Tyr Ile Cys Met Gln Arg Thr Val Asp Lys Thr 
545                 550                 555                 560 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                565                 570                 575     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            580                 585                 590         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        595                 600                 605             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    610                 615                 620                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
625                 630                 635                 640 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                645                 650                 655     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            660                 665                 670         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        675                 680                 685             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    690                 695                 700                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
705                 710                 715                 720 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                725                 730                 735     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            740                 745                 750         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        755                 760                 765             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    770                 775                 780                 


<210> 46
<211> 2352
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 46
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gcacggttag gtccggcggg      840

ggaaaccagg aagtgcagat ccccctgacc gagagctact gcggcccctg ccccaagaac      900

tggatctgct acaagaacaa ctgctaccag ttcttcgacg agagcaagaa ttggtacgag      960

agccaggcca gctgcatgag ccagaacgcc agcctgctga aggtgtacag caaagaggac     1020

caggatctgc tgaagctcgt gaagtcctac cactggatgg gcctggtgca catccccacc     1080

aatggcagct ggcagtggga ggacggcagc atcctgagcc ccaacctgct gaccatcatc     1140

gagatgcaga agggcgactg cgccctgtac gccagcagct tcaagggcta catcgagaac     1200

tgtagcaccc ccaacaccta catctgtatg cagcggaccg tcagaagtgg aggcgggtct     1260

ggaggcggat ccaaccagga agtgcagatc cccctgaccg agagctactg cggcccctgc     1320

cccaagaact ggatctgcta caagaacaac tgctaccagt tcttcgacga gagcaagaat     1380

tggtacgaga gccaggccag ctgcatgagc cagaacgcca gcctgctgaa ggtgtacagc     1440

aaagaggacc aggatctgct gaagctcgtg aagtcctacc actggatggg cctggtgcac     1500

atccccacca atggcagctg gcagtgggag gacggcagca tcctgagccc caacctgctg     1560

accatcatcg agatgcagaa gggcgactgc gccctgtacg ccagcagctt caagggctac     1620

atcgagaact gcagcacccc caacacctac atttgcatgc agcgtacggt tgacaagacc     1680

cacacctgcc ccccctgtcc tgcccctgaa ctgctgggcg gaccctccgt gttcctgttc     1740

cccccaaagc ccaaggacac cctgatgatc agccggaccc ccgaagtgac ctgcgtggtg     1800

gtggacgtgt cccacgagga ccctgaagtg aagttcaatt ggtacgtgga cggcgtggaa     1860

gtgcacaacg ccaagaccaa gcccagagag gaacagtaca acagcaccta ccgggtggtg     1920

tccgtgctga ccgtgctgca ccaggactgg ctgaacggca aagagtacaa gtgcaaagtc     1980

tccaacaagg ccctgcctgc ccccatcgag aaaaccatca gcaaggccaa gggccagccc     2040

cgcgagcccc aggtgtacac actgcccccc agccgggacg agctgaccaa gaaccaggtg     2100

tccctgacct gcctggtcaa gggcttctac cccagcgata tcgccgtgga atgggagagc     2160

aacggccagc ccgagaacaa ctacaagacc accccccctg tgctggacag cgacggctca     2220

ttcttcctgt acagcaagct gaccgtggac aagtcccggt ggcagcaggg caacgtgttc     2280

agctgcagcg tgatgcacga ggccctgcac aaccactaca cccagaagtc cctgagcctg     2340

agccccggca aa                                                         2352


<210> 47
<211> 527
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
1               5                   10                  15      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        35                  40                  45              


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    50                  55                  60                  


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                85                  90                  95      


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            100                 105                 110         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        115                 120                 125             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro 
145                 150                 155                 160 


Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile 
                165                 170                 175     


Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp 
            180                 185                 190         


Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys 
        195                 200                 205             


Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile 
                245                 250                 255     


Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr 
            260                 265                 270         


Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        275                 280                 285             


Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
    290                 295                 300                 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
305                 310                 315                 320 


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
                325                 330                 335     


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
            340                 345                 350         


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
        355                 360                 365             


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
    370                 375                 380                 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
385                 390                 395                 400 


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
                405                 410                 415     


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
            420                 425                 430         


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
        435                 440                 445             


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
    450                 455                 460                 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
465                 470                 475                 480 


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
                485                 490                 495     


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
            500                 505                 510         


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
        515                 520                 525         


<210> 48
<211> 1581
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 48
tttcaacctg tcctgtgtaa caaagaggtt ccagtgagtt caagagaggg atactgcggg       60

ccatgtccga ataactggat ctgccacagg aacaactgct atcagttttt caacgaagaa      120

aagacatgga accagagtca ggcttcctgt ttgtctcaga actccagtct gctgaagatt      180

tactcaaagg aggaacagga cttcctcaaa ctggtaaaga gctatcattg gatgggactg      240

gttcagatcc cagccaatgg ctcttggcag tgggaggatg gaagctctct cagctacaac      300

cagcttaccc tggtggaaat tcccaaagga agctgcgcag tgtatggttc aagtttcaaa      360

gcctacacag aagattgcgc taacctgaat acatacattt gcatgaaaag ggctgtcaga      420

agtggaggcg ggtctggagg cgggtctttc caacctgtcc tgtgcaacaa agaagtgccc      480

gtcagttcca gagagggcta ctgtgggcca tgtcccaata attggatttg ccacagaaac      540

aactgctacc agttctttaa tgaggagaaa acttggaacc agtcacaagc ctcttgtctg      600

tcacaaaaca gcagcttgct gaaaatctac agcaaggagg agcaggactt tctgaagctg      660

gtcaaatctt atcactggat gggtctggtg cagatccccg ccaatggatc ttggcaatgg      720

gaggacggct cttctctctc ctataatcag ctgacactgg tagaaatccc caaagggagc      780

tgtgcagtgt acgggagcag ttttaaggcc tataccgagg attgcgcaaa tttgaacact      840

tacatctgca tgaagagggc cgtcatatca gctatggtcc gctcaccaag aggaccaacc      900

attaagcctt gcccgccatg caagtgcccc gctccaaacc ttctgggagg gccgtctgtg      960

ttcatttttc ctcccaaaat caaagatgtg ctgatgatta gcctgtctcc aatcgtgacc     1020

tgtgttgtcg tggacgtgtc agaggatgac cccgatgtgc agataagttg gtttgtaaac     1080

aatgtagagg tgcacacggc acagacacag acccataggg aggattacaa ttctaccctg     1140

cgggtcgtta gcgccctgcc gatccagcac caggactgga tgtcaggtaa agaatttaag     1200

tgcaaggtga ataataagga tctgcccgct cctattgaga gaacgattag caagcccaag     1260

ggctccgtgc gcgcacccca agtctacgtt cttcctcccc cagaagagga gatgaccaaa     1320

aagcaggtca ccctgacgtg tatggtgact gattttatgc ccgaagatat ttacgtggaa     1380

tggacaaaca acggtaaaac agagctgaac tacaagaata ctgagcccgt gctggactcc     1440

gacggctctt actttatgta tagcaagctg agagttgaga agaaaaattg ggtagagaga     1500

aattcttact catgttctgt tgtacatgaa ggactgcaca atcatcacac cacaaagagt     1560

ttcagtagaa ctccaggtaa a                                               1581


<210> 49
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
1               5                   10                  15      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        35                  40                  45              


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    50                  55                  60                  


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                85                  90                  95      


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            100                 105                 110         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        115                 120                 125             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro 
145                 150                 155                 160 


Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile 
                165                 170                 175     


Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp 
            180                 185                 190         


Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys 
        195                 200                 205             


Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile 
                245                 250                 255     


Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr 
            260                 265                 270         


Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ser Ala Met Val Arg 
    290                 295                 300                 


Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
305                 310                 315                 320 


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
                325                 330                 335     


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
            340                 345                 350         


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        355                 360                 365             


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    370                 375                 380                 


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
385                 390                 395                 400 


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
                405                 410                 415     


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
            420                 425                 430         


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
        435                 440                 445             


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
    450                 455                 460                 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
465                 470                 475                 480 


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
                485                 490                 495     


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
            500                 505                 510         


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
        515                 520                 525             


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    530                 535         


<210> 50
<211> 1611
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 50
tttcaacctg tcctgtgtaa caaagaggtt ccagtgagtt caagagaggg atactgcggg       60

ccatgtccga ataactggat ctgccacagg aacaactgct atcagttttt caacgaagaa      120

aagacatgga accagagtca ggcttcctgt ttgtctcaga actccagtct gctgaagatt      180

tactcaaagg aggaacagga cttcctcaaa ctggtaaaga gctatcattg gatgggactg      240

gttcagatcc cagccaatgg ctcttggcag tgggaggatg gaagctctct cagctacaac      300

cagcttaccc tggtggaaat tcccaaagga agctgcgcag tgtatggttc aagtttcaaa      360

gcctacacag aagattgcgc taacctgaat acatacattt gcatgaaaag ggctgtcaga      420

agtggaggcg ggtctggagg cgggtctttc caacctgtcc tgtgcaacaa agaagtgccc      480

gtcagttcca gagagggcta ctgtgggcca tgtcccaata attggatttg ccacagaaac      540

aactgctacc agttctttaa tgaggagaaa acttggaacc agtcacaagc ctcttgtctg      600

tcacaaaaca gcagcttgct gaaaatctac agcaaggagg agcaggactt tctgaagctg      660

gtcaaatctt atcactggat gggtctggtg cagatccccg ccaatggatc ttggcaatgg      720

gaggacggct cttctctctc ctataatcag ctgacactgg tagaaatccc caaagggagc      780

tgtgcagtgt acgggagcag ttttaaggcc tataccgagg attgcgcaaa tttgaacact      840

tacatctgca tgaagagggc cgtcggtgga gggggctccg gaggcggtgg gagcatatca      900

gctatggtcc gctcaccaag aggaccaacc attaagcctt gcccgccatg caagtgcccc      960

gctccaaacc ttctgggagg gccgtctgtg ttcatttttc ctcccaaaat caaagatgtg     1020

ctgatgatta gcctgtctcc aatcgtgacc tgtgttgtcg tggacgtgtc agaggatgac     1080

cccgatgtgc agataagttg gtttgtaaac aatgtagagg tgcacacggc acagacacag     1140

acccataggg aggattacaa ttctaccctg cgggtcgtta gcgccctgcc gatccagcac     1200

caggactgga tgtcaggtaa agaatttaag tgcaaggtga ataataagga tctgcccgct     1260

cctattgaga gaacgattag caagcccaag ggctccgtgc gcgcacccca agtctacgtt     1320

cttcctcccc cagaagagga gatgaccaaa aagcaggtca ccctgacgtg tatggtgact     1380

gattttatgc ccgaagatat ttacgtggaa tggacaaaca acggtaaaac agagctgaac     1440

tacaagaata ctgagcccgt gctggactcc gacggctctt actttatgta tagcaagctg     1500

agagttgaga agaaaaattg ggtagagaga aattcttact catgttctgt tgtacatgaa     1560

ggactgcaca atcatcacac cacaaagagt ttcagtagaa ctccaggtaa a              1611


<210> 51
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 51
Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
1               5                   10                  15      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        35                  40                  45              


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    50                  55                  60                  


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                85                  90                  95      


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            100                 105                 110         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        115                 120                 125             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro 
145                 150                 155                 160 


Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile 
                165                 170                 175     


Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp 
            180                 185                 190         


Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys 
        195                 200                 205             


Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile 
                245                 250                 255     


Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr 
            260                 265                 270         


Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr 
305                 310                 315                 320 


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
                325                 330                 335     


Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
            340                 345                 350         


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
        355                 360                 365             


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
    370                 375                 380                 


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
385                 390                 395                 400 


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
                405                 410                 415     


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
            420                 425                 430         


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
        435                 440                 445             


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
    450                 455                 460                 


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
465                 470                 475                 480 


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
                485                 490                 495     


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
            500                 505                 510         


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
        515                 520                 525             


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
    530                 535                 540                 


Pro Gly Lys 
545         


<210> 52
<211> 1641
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 52
tttcaacctg tcctgtgtaa caaagaggtt ccagtgagtt caagagaggg atactgcggg       60

ccatgtccga ataactggat ctgccacagg aacaactgct atcagttttt caacgaagaa      120

aagacatgga accagagtca ggcttcctgt ttgtctcaga actccagtct gctgaagatt      180

tactcaaagg aggaacagga cttcctcaaa ctggtaaaga gctatcattg gatgggactg      240

gttcagatcc cagccaatgg ctcttggcag tgggaggatg gaagctctct cagctacaac      300

cagcttaccc tggtggaaat tcccaaagga agctgcgcag tgtatggttc aagtttcaaa      360

gcctacacag aagattgcgc taacctgaat acatacattt gcatgaaaag ggctgtcaga      420

agtggaggcg ggtctggagg cgggtctttc caacctgtcc tgtgcaacaa agaagtgccc      480

gtcagttcca gagagggcta ctgtgggcca tgtcccaata attggatttg ccacagaaac      540

aactgctacc agttctttaa tgaggagaaa acttggaacc agtcacaagc ctcttgtctg      600

tcacaaaaca gcagcttgct gaaaatctac agcaaggagg agcaggactt tctgaagctg      660

gtcaaatctt atcactggat gggtctggtg cagatccccg ccaatggatc ttggcaatgg      720

gaggacggct cttctctctc ctataatcag ctgacactgg tagaaatccc caaagggagc      780

tgtgcagtgt acgggagcag ttttaaggcc tataccgagg attgcgcaaa tttgaacact      840

tacatctgca tgaagagggc cgtcggtgga gggggcagcg gaggtggggg cagcggggga      900

ggtgggtccg gaggcggtgg gagcatatca gctatggtcc gctcaccaag aggaccaacc      960

attaagcctt gcccgccatg caagtgcccc gctccaaacc ttctgggagg gccgtctgtg     1020

ttcatttttc ctcccaaaat caaagatgtg ctgatgatta gcctgtctcc aatcgtgacc     1080

tgtgttgtcg tggacgtgtc agaggatgac cccgatgtgc agataagttg gtttgtaaac     1140

aatgtagagg tgcacacggc acagacacag acccataggg aggattacaa ttctaccctg     1200

cgggtcgtta gcgccctgcc gatccagcac caggactgga tgtcaggtaa agaatttaag     1260

tgcaaggtga ataataagga tctgcccgct cctattgaga gaacgattag caagcccaag     1320

ggctccgtgc gcgcacccca agtctacgtt cttcctcccc cagaagagga gatgaccaaa     1380

aagcaggtca ccctgacgtg tatggtgact gattttatgc ccgaagatat ttacgtggaa     1440

tggacaaaca acggtaaaac agagctgaac tacaagaata ctgagcccgt gctggactcc     1500

gacggctctt actttatgta tagcaagctg agagttgaga agaaaaattg ggtagagaga     1560

aattcttact catgttctgt tgtacatgaa ggactgcaca atcatcacac cacaaagagt     1620

ttcagtagaa ctccaggtaa a                                               1641


<210> 53
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 53
Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu 
1               5                   10                  15      


Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn 
            20                  25                  30          


Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala 
        35                  40                  45              


Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu 
    50                  55                  60                  


Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu 
65                  70                  75                  80  


Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser 
                85                  90                  95      


Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys 
            100                 105                 110         


Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn 
        115                 120                 125             


Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly 
    130                 135                 140                 


Ser Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro 
145                 150                 155                 160 


Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile 
                165                 170                 175     


Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp 
            180                 185                 190         


Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys 
        195                 200                 205             


Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr 
    210                 215                 220                 


His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp 
225                 230                 235                 240 


Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile 
                245                 250                 255     


Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr 
            260                 265                 270         


Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        275                 280                 285             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    290                 295                 300                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Ile Ser 
305                 310                 315                 320 


Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
                325                 330                 335     


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile 
            340                 345                 350         


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
        355                 360                 365             


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
    370                 375                 380                 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
385                 390                 395                 400 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
                405                 410                 415     


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
            420                 425                 430         


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
        435                 440                 445             


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
    450                 455                 460                 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
465                 470                 475                 480 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
                485                 490                 495     


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
            500                 505                 510         


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
        515                 520                 525             


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
    530                 535                 540                 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
545                 550                 555         


<210> 54
<211> 1671
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 54
tttcaacctg tcctgtgtaa caaagaggtt ccagtgagtt caagagaggg atactgcggg       60

ccatgtccga ataactggat ctgccacagg aacaactgct atcagttttt caacgaagaa      120

aagacatgga accagagtca ggcttcctgt ttgtctcaga actccagtct gctgaagatt      180

tactcaaagg aggaacagga cttcctcaaa ctggtaaaga gctatcattg gatgggactg      240

gttcagatcc cagccaatgg ctcttggcag tgggaggatg gaagctctct cagctacaac      300

cagcttaccc tggtggaaat tcccaaagga agctgcgcag tgtatggttc aagtttcaaa      360

gcctacacag aagattgcgc taacctgaat acatacattt gcatgaaaag ggctgtcaga      420

agtggaggcg ggtctggagg cgggtctttc caacctgtcc tgtgcaacaa agaagtgccc      480

gtcagttcca gagagggcta ctgtgggcca tgtcccaata attggatttg ccacagaaac      540

aactgctacc agttctttaa tgaggagaaa acttggaacc agtcacaagc ctcttgtctg      600

tcacaaaaca gcagcttgct gaaaatctac agcaaggagg agcaggactt tctgaagctg      660

gtcaaatctt atcactggat gggtctggtg cagatccccg ccaatggatc ttggcaatgg      720

gaggacggct cttctctctc ctataatcag ctgacactgg tagaaatccc caaagggagc      780

tgtgcagtgt acgggagcag ttttaaggcc tataccgagg attgcgcaaa tttgaacact      840

tacatctgca tgaagagggc cgtcggtgga gggggctccg gaggtggggg cagcggggga      900

ggtgggtccg gtgggggagg ctctggcgga ggtgggtctg gaggcggtgg gagcatatca      960

gctatggtcc gctcaccaag aggaccaacc attaagcctt gcccgccatg caagtgcccc     1020

gctccaaacc ttctgggagg gccgtctgtg ttcatttttc ctcccaaaat caaagatgtg     1080

ctgatgatta gcctgtctcc aatcgtgacc tgtgttgtcg tggacgtgtc agaggatgac     1140

cccgatgtgc agataagttg gtttgtaaac aatgtagagg tgcacacggc acagacacag     1200

acccataggg aggattacaa ttctaccctg cgggtcgtta gcgccctgcc gatccagcac     1260

caggactgga tgtcaggtaa agaatttaag tgcaaggtga ataataagga tctgcccgct     1320

cctattgaga gaacgattag caagcccaag ggctccgtgc gcgcacccca agtctacgtt     1380

cttcctcccc cagaagagga gatgaccaaa aagcaggtca ccctgacgtg tatggtgact     1440

gattttatgc ccgaagatat ttacgtggaa tggacaaaca acggtaaaac agagctgaac     1500

tacaagaata ctgagcccgt gctggactcc gacggctctt actttatgta tagcaagctg     1560

agagttgaga agaaaaattg ggtagagaga aattcttact catgttctgt tgtacatgaa     1620

ggactgcaca atcatcacac cacaaagagt ttcagtagaa ctccaggtaa a              1671


<210> 55
<211> 527
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 55
Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
1               5                   10                  15      


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        35                  40                  45              


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    130                 135                 140                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
145                 150                 155                 160 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                165                 170                 175     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        195                 200                 205             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    210                 215                 220                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Phe 
225                 230                 235                 240 


Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly 
                245                 250                 255     


Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys 
            260                 265                 270         


Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser 
        275                 280                 285             


Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu 
    290                 295                 300                 


Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val 
305                 310                 315                 320 


Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu 
                325                 330                 335     


Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala 
            340                 345                 350         


Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu 
        355                 360                 365             


Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly Ser 
    370                 375                 380                 


Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val 
385                 390                 395                 400 


Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys 
                405                 410                 415     


His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn 
            420                 425                 430         


Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile 
        435                 440                 445             


Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His 
    450                 455                 460                 


Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu 
465                 470                 475                 480 


Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro 
                485                 490                 495     


Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu 
            500                 505                 510         


Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
        515                 520                 525         


<210> 56
<211> 1581
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 56
atatcagcta tggtccgctc accaagagga ccaaccatta agccttgccc gccatgcaag       60

tgccccgctc caaaccttct gggagggccg tctgtgttca tttttcctcc caaaatcaaa      120

gatgtgctga tgattagcct gtctccaatc gtgacctgtg ttgtcgtgga cgtgtcagag      180

gatgaccccg atgtgcagat aagttggttt gtaaacaatg tagaggtgca cacggcacag      240

acacagaccc atagggagga ttacaattct accctgcggg tcgttagcgc cctgccgatc      300

cagcaccagg actggatgtc aggtaaagaa tttaagtgca aggtgaataa taaggatctg      360

cccgctccta ttgagagaac gattagcaag cccaagggct ccgtgcgcgc accccaagtc      420

tacgttcttc ctcccccaga agaggagatg accaaaaagc aggtcaccct gacgtgtatg      480

gtgactgatt ttatgcccga agatatttac gtggaatgga caaacaacgg taaaacagag      540

ctgaactaca agaatactga gcccgtgctg gactccgacg gctcttactt tatgtatagc      600

aagctgagag ttgagaagaa aaattgggta gagagaaatt cttactcatg ttctgttgta      660

catgaaggac tgcacaatca tcacaccaca aagagtttca gtagaactcc aggtaaattt      720

caacctgtcc tgtgtaacaa agaggttcca gtgagttcaa gagagggata ctgcgggcca      780

tgtccgaata actggatctg ccacaggaac aactgctatc agtttttcaa cgaagaaaag      840

acatggaacc agagtcaggc ttcctgtttg tctcagaact ccagtctgct gaagatttac      900

tcaaaggagg aacaggactt cctcaaactg gtaaagagct atcattggat gggactggtt      960

cagatcccag ccaatggctc ttggcagtgg gaggatggaa gctctctcag ctacaaccag     1020

cttaccctgg tggaaattcc caaaggaagc tgcgcagtgt atggttcaag tttcaaagcc     1080

tacacagaag attgcgctaa cctgaataca tacatttgca tgaaaagggc tgtcagaagt     1140

ggaggcgggt ctggaggcgg gtctttccaa cctgtcctgt gcaacaaaga agtgcccgtc     1200

agttccagag agggctactg tgggccatgt cccaataatt ggatttgcca cagaaacaac     1260

tgctaccagt tctttaatga ggagaaaact tggaaccagt cacaagcctc ttgtctgtca     1320

caaaacagca gcttgctgaa aatctacagc aaggaggagc aggactttct gaagctggtc     1380

aaatcttatc actggatggg tctggtgcag atccccgcca atggatcttg gcaatgggag     1440

gacggctctt ctctctccta taatcagctg acactggtag aaatccccaa agggagctgt     1500

gcagtgtacg ggagcagttt taaggcctat accgaggatt gcgcaaattt gaacacttac     1560

atctgcatga agagggccgt c                                               1581


<210> 57
<211> 537
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 57
Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
1               5                   10                  15      


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        35                  40                  45              


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    130                 135                 140                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
145                 150                 155                 160 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                165                 170                 175     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        195                 200                 205             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    210                 215                 220                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn 
                245                 250                 255     


Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro 
            260                 265                 270         


Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu 
        275                 280                 285             


Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser 
    290                 295                 300                 


Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu 
305                 310                 315                 320 


Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly 
                325                 330                 335     


Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr 
            340                 345                 350         


Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe 
        355                 360                 365             


Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met 
    370                 375                 380                 


Lys Arg Ala Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Phe Gln 
385                 390                 395                 400 


Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr 
                405                 410                 415     


Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr 
            420                 425                 430         


Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys 
        435                 440                 445             


Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln 
    450                 455                 460                 


Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln 
465                 470                 475                 480 


Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser 
                485                 490                 495     


Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val 
            500                 505                 510         


Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn 
        515                 520                 525             


Thr Tyr Ile Cys Met Lys Arg Ala Val 
    530                 535         


<210> 58
<211> 1611
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 58
atatcagcta tggtccgctc accaagagga ccaaccatta agccttgccc gccatgcaag       60

tgccccgctc caaaccttct gggagggccg tctgtgttca tttttcctcc caaaatcaaa      120

gatgtgctga tgattagcct gtctccaatc gtgacctgtg ttgtcgtgga cgtgtcagag      180

gatgaccccg atgtgcagat aagttggttt gtaaacaatg tagaggtgca cacggcacag      240

acacagaccc atagggagga ttacaattct accctgcggg tcgttagcgc cctgccgatc      300

cagcaccagg actggatgtc aggtaaagaa tttaagtgca aggtgaataa taaggatctg      360

cccgctccta ttgagagaac gattagcaag cccaagggct ccgtgcgcgc accccaagtc      420

tacgttcttc ctcccccaga agaggagatg accaaaaagc aggtcaccct gacgtgtatg      480

gtgactgatt ttatgcccga agatatttac gtggaatgga caaacaacgg taaaacagag      540

ctgaactaca agaatactga gcccgtgctg gactccgacg gctcttactt tatgtatagc      600

aagctgagag ttgagaagaa aaattgggta gagagaaatt cttactcatg ttctgttgta      660

catgaaggac tgcacaatca tcacaccaca aagagtttca gtagaactcc aggtaaaggt      720

ggagggggct ccggaggcgg tgggagcttt caacctgtcc tgtgtaacaa agaggttcca      780

gtgagttcaa gagagggata ctgcgggcca tgtccgaata actggatctg ccacaggaac      840

aactgctatc agtttttcaa cgaagaaaag acatggaacc agagtcaggc ttcctgtttg      900

tctcagaact ccagtctgct gaagatttac tcaaaggagg aacaggactt cctcaaactg      960

gtaaagagct atcattggat gggactggtt cagatcccag ccaatggctc ttggcagtgg     1020

gaggatggaa gctctctcag ctacaaccag cttaccctgg tggaaattcc caaaggaagc     1080

tgcgcagtgt atggttcaag tttcaaagcc tacacagaag attgcgctaa cctgaataca     1140

tacatttgca tgaaaagggc tgtcagaagt ggaggcgggt ctggaggcgg gtctttccaa     1200

cctgtcctgt gcaacaaaga agtgcccgtc agttccagag agggctactg tgggccatgt     1260

cccaataatt ggatttgcca cagaaacaac tgctaccagt tctttaatga ggagaaaact     1320

tggaaccagt cacaagcctc ttgtctgtca caaaacagca gcttgctgaa aatctacagc     1380

aaggaggagc aggactttct gaagctggtc aaatcttatc actggatggg tctggtgcag     1440

atccccgcca atggatcttg gcaatgggag gacggctctt ctctctccta taatcagctg     1500

acactggtag aaatccccaa agggagctgt gcagtgtacg ggagcagttt taaggcctat     1560

accgaggatt gcgcaaattt gaacacttac atctgcatga agagggccgt c              1611


<210> 59
<211> 547
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 59
Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
1               5                   10                  15      


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        35                  40                  45              


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    130                 135                 140                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
145                 150                 155                 160 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                165                 170                 175     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        195                 200                 205             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    210                 215                 220                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser 
            260                 265                 270         


Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His 
        275                 280                 285             


Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln 
    290                 295                 300                 


Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr 
305                 310                 315                 320 


Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp 
                325                 330                 335     


Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp 
            340                 345                 350         


Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys 
        355                 360                 365             


Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp 
    370                 375                 380                 


Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val Arg Ser 
385                 390                 395                 400 


Gly Gly Gly Ser Gly Gly Gly Ser Phe Gln Pro Val Leu Cys Asn Lys 
                405                 410                 415     


Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn 
            420                 425                 430         


Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu 
        435                 440                 445             


Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser 
    450                 455                 460                 


Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp Phe Leu Lys Leu Val 
465                 470                 475                 480 


Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile Pro Ala Asn Gly Ser 
                485                 490                 495     


Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu 
            500                 505                 510         


Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys 
        515                 520                 525             


Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys 
    530                 535                 540                 


Arg Ala Val 
545         


<210> 60
<211> 1641
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 60
atatcagcta tggtccgctc accaagagga ccaaccatta agccttgccc gccatgcaag       60

tgccccgctc caaaccttct gggagggccg tctgtgttca tttttcctcc caaaatcaaa      120

gatgtgctga tgattagcct gtctccaatc gtgacctgtg ttgtcgtgga cgtgtcagag      180

gatgaccccg atgtgcagat aagttggttt gtaaacaatg tagaggtgca cacggcacag      240

acacagaccc atagggagga ttacaattct accctgcggg tcgttagcgc cctgccgatc      300

cagcaccagg actggatgtc aggtaaagaa tttaagtgca aggtgaataa taaggatctg      360

cccgctccta ttgagagaac gattagcaag cccaagggct ccgtgcgcgc accccaagtc      420

tacgttcttc ctcccccaga agaggagatg accaaaaagc aggtcaccct gacgtgtatg      480

gtgactgatt ttatgcccga agatatttac gtggaatgga caaacaacgg taaaacagag      540

ctgaactaca agaatactga gcccgtgctg gactccgacg gctcttactt tatgtatagc      600

aagctgagag ttgagaagaa aaattgggta gagagaaatt cttactcatg ttctgttgta      660

catgaaggac tgcacaatca tcacaccaca aagagtttca gtagaactcc aggtaaaggt      720

ggagggggca gcggaggtgg gggcagcggg ggaggtgggt ccggaggcgg tgggagcttt      780

caacctgtcc tgtgtaacaa agaggttcca gtgagttcaa gagagggata ctgcgggcca      840

tgtccgaata actggatctg ccacaggaac aactgctatc agtttttcaa cgaagaaaag      900

acatggaacc agagtcaggc ttcctgtttg tctcagaact ccagtctgct gaagatttac      960

tcaaaggagg aacaggactt cctcaaactg gtaaagagct atcattggat gggactggtt     1020

cagatcccag ccaatggctc ttggcagtgg gaggatggaa gctctctcag ctacaaccag     1080

cttaccctgg tggaaattcc caaaggaagc tgcgcagtgt atggttcaag tttcaaagcc     1140

tacacagaag attgcgctaa cctgaataca tacatttgca tgaaaagggc tgtcagaagt     1200

ggaggcgggt ctggaggcgg gtctttccaa cctgtcctgt gcaacaaaga agtgcccgtc     1260

agttccagag agggctactg tgggccatgt cccaataatt ggatttgcca cagaaacaac     1320

tgctaccagt tctttaatga ggagaaaact tggaaccagt cacaagcctc ttgtctgtca     1380

caaaacagca gcttgctgaa aatctacagc aaggaggagc aggactttct gaagctggtc     1440

aaatcttatc actggatggg tctggtgcag atccccgcca atggatcttg gcaatgggag     1500

gacggctctt ctctctccta taatcagctg acactggtag aaatccccaa agggagctgt     1560

gcagtgtacg ggagcagttt taaggcctat accgaggatt gcgcaaattt gaacacttac     1620

atctgcatga agagggccgt c                                               1641


<210> 61
<211> 557
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
1               5                   10                  15      


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        35                  40                  45              


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    130                 135                 140                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
145                 150                 155                 160 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                165                 170                 175     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        195                 200                 205             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    210                 215                 220                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys Gly 
225                 230                 235                 240 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Phe Gln Pro 
            260                 265                 270         


Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser Arg Glu Gly Tyr Cys 
        275                 280                 285             


Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg Asn Asn Cys Tyr Gln 
    290                 295                 300                 


Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser Gln Ala Ser Cys Leu 
305                 310                 315                 320 


Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser Lys Glu Glu Gln Asp 
                325                 330                 335     


Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met Gly Leu Val Gln Ile 
            340                 345                 350         


Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly Ser Ser Leu Ser Tyr 
        355                 360                 365             


Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly Ser Cys Ala Val Tyr 
    370                 375                 380                 


Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys Ala Asn Leu Asn Thr 
385                 390                 395                 400 


Tyr Ile Cys Met Lys Arg Ala Val Arg Ser Gly Gly Gly Ser Gly Gly 
                405                 410                 415     


Gly Ser Phe Gln Pro Val Leu Cys Asn Lys Glu Val Pro Val Ser Ser 
            420                 425                 430         


Arg Glu Gly Tyr Cys Gly Pro Cys Pro Asn Asn Trp Ile Cys His Arg 
        435                 440                 445             


Asn Asn Cys Tyr Gln Phe Phe Asn Glu Glu Lys Thr Trp Asn Gln Ser 
    450                 455                 460                 


Gln Ala Ser Cys Leu Ser Gln Asn Ser Ser Leu Leu Lys Ile Tyr Ser 
465                 470                 475                 480 


Lys Glu Glu Gln Asp Phe Leu Lys Leu Val Lys Ser Tyr His Trp Met 
                485                 490                 495     


Gly Leu Val Gln Ile Pro Ala Asn Gly Ser Trp Gln Trp Glu Asp Gly 
            500                 505                 510         


Ser Ser Leu Ser Tyr Asn Gln Leu Thr Leu Val Glu Ile Pro Lys Gly 
        515                 520                 525             


Ser Cys Ala Val Tyr Gly Ser Ser Phe Lys Ala Tyr Thr Glu Asp Cys 
    530                 535                 540                 


Ala Asn Leu Asn Thr Tyr Ile Cys Met Lys Arg Ala Val 
545                 550                 555         


<210> 62
<211> 1671
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 62
atatcagcta tggtccgctc accaagagga ccaaccatta agccttgccc gccatgcaag       60

tgccccgctc caaaccttct gggagggccg tctgtgttca tttttcctcc caaaatcaaa      120

gatgtgctga tgattagcct gtctccaatc gtgacctgtg ttgtcgtgga cgtgtcagag      180

gatgaccccg atgtgcagat aagttggttt gtaaacaatg tagaggtgca cacggcacag      240

acacagaccc atagggagga ttacaattct accctgcggg tcgttagcgc cctgccgatc      300

cagcaccagg actggatgtc aggtaaagaa tttaagtgca aggtgaataa taaggatctg      360

cccgctccta ttgagagaac gattagcaag cccaagggct ccgtgcgcgc accccaagtc      420

tacgttcttc ctcccccaga agaggagatg accaaaaagc aggtcaccct gacgtgtatg      480

gtgactgatt ttatgcccga agatatttac gtggaatgga caaacaacgg taaaacagag      540

ctgaactaca agaatactga gcccgtgctg gactccgacg gctcttactt tatgtatagc      600

aagctgagag ttgagaagaa aaattgggta gagagaaatt cttactcatg ttctgttgta      660

catgaaggac tgcacaatca tcacaccaca aagagtttca gtagaactcc aggtaaaggt      720

ggagggggct ccggaggtgg gggcagcggg ggaggtgggt ccggtggggg aggctctggc      780

ggaggtgggt ctggaggcgg tgggagcttt caacctgtcc tgtgtaacaa agaggttcca      840

gtgagttcaa gagagggata ctgcgggcca tgtccgaata actggatctg ccacaggaac      900

aactgctatc agtttttcaa cgaagaaaag acatggaacc agagtcaggc ttcctgtttg      960

tctcagaact ccagtctgct gaagatttac tcaaaggagg aacaggactt cctcaaactg     1020

gtaaagagct atcattggat gggactggtt cagatcccag ccaatggctc ttggcagtgg     1080

gaggatggaa gctctctcag ctacaaccag cttaccctgg tggaaattcc caaaggaagc     1140

tgcgcagtgt atggttcaag tttcaaagcc tacacagaag attgcgctaa cctgaataca     1200

tacatttgca tgaaaagggc tgtcagaagt ggaggcgggt ctggaggcgg gtctttccaa     1260

cctgtcctgt gcaacaaaga agtgcccgtc agttccagag agggctactg tgggccatgt     1320

cccaataatt ggatttgcca cagaaacaac tgctaccagt tctttaatga ggagaaaact     1380

tggaaccagt cacaagcctc ttgtctgtca caaaacagca gcttgctgaa aatctacagc     1440

aaggaggagc aggactttct gaagctggtc aaatcttatc actggatggg tctggtgcag     1500

atccccgcca atggatcttg gcaatgggag gacggctctt ctctctccta taatcagctg     1560

acactggtag aaatccccaa agggagctgt gcagtgtacg ggagcagttt taaggcctat     1620

accgaggatt gcgcaaattt gaacacttac atctgcatga agagggccgt c              1671


<210> 63
<211> 239
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Ile Ser Ala Met Val Arg Ser Pro Arg Gly Pro Thr Ile Lys Pro Cys 
1               5                   10                  15      


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
            20                  25                  30          


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
        35                  40                  45              


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
    50                  55                  60                  


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
65                  70                  75                  80  


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
                85                  90                  95      


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
            100                 105                 110         


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
        115                 120                 125             


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
    130                 135                 140                 


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
145                 150                 155                 160 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
                165                 170                 175     


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
            180                 185                 190         


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
        195                 200                 205             


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
    210                 215                 220                 


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230                 235                 


<210> 64
<211> 107
<212> PRT
<213> Homo sapiens

<400> 64
Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210> 65
<211> 330
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 
            100                 105                 110         


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
        115                 120                 125             


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
    130                 135                 140                 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
145                 150                 155                 160 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
                165                 170                 175     


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
            180                 185                 190         


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
        195                 200                 205             


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
    210                 215                 220                 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
225                 230                 235                 240 


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
                245                 250                 255     


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
            260                 265                 270         


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
        275                 280                 285             


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
    290                 295                 300                 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
305                 310                 315                 320 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                325                 330 


<210> 66
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 66
Gly Gly Gly Ser 
1               


<210> 67
<211> 284
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Asn Trp Val Asn Val Ile Ser Asp Leu Lys Lys Ile Glu Asp Leu Ile 
1               5                   10                  15      


Gln Ser Met His Ile Asp Ala Thr Leu Tyr Thr Glu Ser Asp Val His 
            20                  25                  30          


Pro Ser Cys Lys Val Thr Ala Met Lys Cys Phe Leu Leu Glu Leu Gln 
        35                  40                  45              


Val Ile Ser Leu Glu Ser Gly Asp Ala Ser Ile His Asp Thr Val Glu 
    50                  55                  60                  


Asn Leu Ile Ile Leu Ala Asn Asn Ser Leu Ser Ser Asn Gly Asn Val 
65                  70                  75                  80  


Thr Glu Ser Gly Cys Lys Glu Cys Glu Glu Leu Glu Glu Lys Asn Ile 
                85                  90                  95      


Lys Glu Phe Leu Gln Ser Phe Val His Ile Val Gln Met Phe Ile Asn 
            100                 105                 110         


Thr Ser Ile Thr Cys Pro Pro Pro Met Ser Val Glu His Ala Asp Ile 
        115                 120                 125             


Trp Val Lys Ser Tyr Ser Leu Tyr Ser Arg Glu Arg Tyr Ile Cys Asn 
    130                 135                 140                 


Ser Gly Phe Lys Arg Lys Ala Gly Thr Ser Ser Leu Thr Glu Cys Val 
145                 150                 155                 160 


Leu Asn Lys Ala Thr Asn Val Ala His Trp Thr Thr Pro Ser Leu Lys 
                165                 170                 175     


Cys Ile Arg Asp Pro Ala Leu Val His Gln Arg Pro Ala Pro Pro Ser 
            180                 185                 190         


Thr Val Thr Thr Ala Gly Val Thr Pro Gln Pro Glu Ser Leu Ser Pro 
        195                 200                 205             


Ser Gly Lys Glu Pro Ala Ala Ser Ser Pro Ser Ser Asn Asn Thr Ala 
    210                 215                 220                 


Ala Thr Thr Ala Ala Ile Val Pro Gly Ser Gln Leu Met Pro Ser Lys 
225                 230                 235                 240 


Ser Pro Ser Thr Gly Thr Thr Glu Ile Ser Ser His Glu Ser Ser His 
                245                 250                 255     


Gly Thr Pro Ser Gln Thr Thr Ala Lys Asn Trp Glu Leu Thr Ala Ser 
            260                 265                 270         


Ala Ser His Gln Pro Pro Gly Val Tyr Pro Gln Gly 
        275                 280                 


<210> 68
<211> 227
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Ala Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Ala Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Ala Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210> 69
<211> 503
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys 
1               5                   10                  15      


Pro Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp 
            20                  25                  30          


Glu Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn 
        35                  40                  45              


Ala Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys 
    50                  55                  60                  


Leu Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn 
65                  70                  75                  80  


Gly Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu 
                85                  90                  95      


Thr Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser 
            100                 105                 110         


Phe Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys 
        115                 120                 125             


Met Gln Arg Thr Val Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser Asn 
    130                 135                 140                 


Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Cys Gly Pro Cys Pro 
145                 150                 155                 160 


Lys Asn Trp Ile Cys Tyr Lys Asn Asn Cys Tyr Gln Phe Phe Asp Glu 
                165                 170                 175     


Ser Lys Asn Trp Tyr Glu Ser Gln Ala Ser Cys Met Ser Gln Asn Ala 
            180                 185                 190         


Ser Leu Leu Lys Val Tyr Ser Lys Glu Asp Gln Asp Leu Leu Lys Leu 
        195                 200                 205             


Val Lys Ser Tyr His Trp Met Gly Leu Val His Ile Pro Thr Asn Gly 
    210                 215                 220                 


Ser Trp Gln Trp Glu Asp Gly Ser Ile Leu Ser Pro Asn Leu Leu Thr 
225                 230                 235                 240 


Ile Ile Glu Met Gln Lys Gly Asp Cys Ala Leu Tyr Ala Ser Ser Phe 
                245                 250                 255     


Lys Gly Tyr Ile Glu Asn Cys Ser Thr Pro Asn Thr Tyr Ile Cys Met 
            260                 265                 270         


Gln Arg Thr Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro 
        275                 280                 285             


Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
    290                 295                 300                 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
305                 310                 315                 320 


Ala Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
                325                 330                 335     


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
            340                 345                 350         


Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
        355                 360                 365             


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
    370                 375                 380                 


Ala Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
385                 390                 395                 400 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
                405                 410                 415     


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
            420                 425                 430         


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
        435                 440                 445             


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
    450                 455                 460                 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
465                 470                 475                 480 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
                485                 490                 495     


Leu Ser Leu Ser Pro Gly Lys 
            500             


<210> 70
<211> 1509
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polynucleotide"

<400> 70
aaccaggaag tgcagatccc cctgaccgag agctactgcg gcccctgccc caagaactgg       60

atctgctaca agaacaactg ctaccagttc ttcgacgaga gcaagaattg gtacgagagc      120

caggccagct gcatgagcca gaacgccagc ctgctgaagg tgtacagcaa agaggaccag      180

gatctgctga agctcgtgaa gtcctaccac tggatgggcc tggtgcacat ccccaccaat      240

ggcagctggc agtgggagga cggcagcatc ctgagcccca acctgctgac catcatcgag      300

atgcagaagg gcgactgcgc cctgtacgcc agcagcttca agggctacat cgagaactgt      360

agcaccccca acacctacat ctgtatgcag cggaccgtca gaagtggagg cgggtctgga      420

ggcggatcca accaggaagt gcagatcccc ctgaccgaga gctactgcgg cccctgcccc      480

aagaactgga tctgctacaa gaacaactgc taccagttct tcgacgagag caagaattgg      540

tacgagagcc aggccagctg catgagccag aacgccagcc tgctgaaggt gtacagcaaa      600

gaggaccagg atctgctgaa gctcgtgaag tcctaccact ggatgggcct ggtgcacatc      660

cccaccaatg gcagctggca gtgggaggac ggcagcatcc tgagccccaa cctgctgacc      720

atcatcgaga tgcagaaggg cgactgcgcc ctgtacgcca gcagcttcaa gggctacatc      780

gagaactgca gcacccccaa cacctacatt tgcatgcagc gtacggttga caagacccac      840

acctgccctc cctgtccagc ccctgaactg ctgggaggcc ctagcgtgtt cctgttcccc      900

ccaaagccca aggacaccct gatgatcagc cggacccccg aagtgacctg tgtggtggtg      960

gccgtgtctc acgaggaccc tgaagtgaag tttaattggt acgtggacgg cgtggaagtg     1020

cacaacgcca agaccaagcc cagagaggaa cagtacgcca gcacctaccg ggtggtgtcc     1080

gtgctgacag tgctgcacca ggactggctg aacggcaaag agtacaagtg caaggtgtcc     1140

aacaaggccc tggccgctcc catcgagaaa accatcagca aggccaaggg ccagccccgc     1200

gaaccccagg tgtacacact gccccctagc agggacgagc tgaccaagaa ccaggtgtcc     1260

ctgacctgcc tcgtgaaggg cttctacccc tccgatatcg ccgtggaatg ggagagcaac     1320

ggccagcccg agaacaacta caagaccacc ccccctgtgc tggactccga cggctcattc     1380

ttcctgtaca gcaagctgac cgtggacaag tcccggtggc agcagggcaa cgtgttcagc     1440

tgctccgtga tgcacgaggc cctgcacaac cactacaccc agaagtccct gagcctgagc     1500

cccggcaaa                                                             1509


<210> 71
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 71
Phe Leu Asn Ser Leu Phe 
1               5       


<210> 72
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 72
Gly Gly Gly Gly Ala 
1               5   


<210> 73
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 73
Gly Gly Gly Gly Pro 
1               5   


<210> 74
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 74
Gly Gly Gly Ala 
1               


<210> 75
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 75
Arg Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10  


<210> 76
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 76
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


