                         SEQUENCE LISTING

<110>  UCL BUSINESS LTD
 
<120>  GENE THERAPY COMPOSITION AND TREATMENT OF RIGHT VENTRICULAR 
       ARRYTHMOGENIC CARDIOMYOPATHY

<130>  U07934WO

<150>  US 62/903,103
<151>  2019-09-20

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2764
<212>  DNA
<213>  Homo sapiens

<400>  1
gagtccagag gcaggcgagc agctcggtcg cccccaccgg ccccatggca gcccccggcg       60

ccccagctga gtacggctac atccggaccg tcctgggcca gcagatcctg ggacaactgg      120

acagctccag cctggcgctg ccctccgagg ccaagctgaa gctggcgggg agcagcggcc      180

gcggcggcca gacagtcaag agcctgcgga tccaggagca ggtgcagcag accctcgccc      240

ggaagggccg cagctccgtg ggcaacggaa atcttcaccg aaccagcagt gttcctgagt      300

atgtctacaa cctacacttg gttgaaaatg attttgttgg aggccgttcc cctgttccta      360

aaacctatga catgctaaag gctggcacaa ctgccactta tgaaggtcgc tggggaagag      420

gaacagcaca gtacagctcc cagaagtccg tggaagaaag gtccttgagg catcctctga      480

ggagactgga gatttctcct gacagcagcc cggagagggc tcactacacg cacagcgatt      540

accagtacag ccagagaagc caggctgggc acaccctgca ccaccaagaa agcaggcggg      600

ccgccctcct agtgccaccg agatatgctc gttccgagat cgtgggggtc agccgtgctg      660

gcaccacaag caggcagcgc cactttgaca cataccacag acagtaccag catggctctg      720

ttagcgacac cgtttttgac agcatccctg ccaacccggc cctgctcacg taccccaggc      780

cagggaccag ccgcagcatg ggcaacctct tggagaagga gaactacctg acggcagggc      840

tcactgtcgg gcaggtcagg ccgctggtgc ccctgcagcc cgtcactcag aacagggctt      900

ccaggtcctc ctggcatcag agctccttcc acagcacccg cacgctgagg gaagctgggc      960

ccagtgtcgc cgtggattcc agcgggagga gagcgcactt gactgtcggc caggcggccg     1020

cagggggaag tgggaatctg ctcactgaga gaagcacttt cactgactcc cagctgggga     1080

atgcagacat ggagatgact ctggagcgag cagtgagtat gctcgaggca gaccacatgc     1140

tgccatccag gatttctgct gcagctactt tcatacagca cgagtgcttc cagaaatctg     1200

aagctcggaa gagggttaac cagcttcgtg gcatcctcaa gcttctgcag ctcctaaaag     1260

ttcagaatga agacgttcag cgagctgtgt gtggggcctt gagaaactta gtatttgaag     1320

acaatgacaa caaattggag gtggctgaac taaatggggt acctcggctg ctccaggtgc     1380

tgaagcaaac cagagacttg gagactaaaa aacaaataac aggtttgctg tggaatttgt     1440

catctaatga caaactcaag aatctcatga taacagaagc attgcttacg ctgacggaga     1500

atatcatcat ccccttttct gggtggcctg aaggagacta cccaaaagca aatggtttgc     1560

tcgattttga catattctac aacgtcactg gatgcctaag aaacatgagt tctgctggcg     1620

ctgatgggag aaaagcgatg agaagatgtg acggactcat tgactcactg gtccattatg     1680

tcagaggaac cattgcagat taccagccag atgacaaggc cacggagaat tgtgtgtgca     1740

ttcttcataa cctctcctac cagctggagg cagagctccc agagaaatat tcccagaata     1800

tctatattca aaaccggaat atccagactg acaacaacaa aagtattgga tgttttggca     1860

gtcgaagcag gaaagtaaaa gagcaatacc aggacgtgcc gatgccggag gaaaagagca     1920

accccaaggg cgtggagtgg ctgtggcatt ccattgttat aaggatgtat ctgtccttga     1980

tcgccaaaag tgtccgcaac tacacacaag aagcatcctt aggagctctg cagaacctca     2040

cggccggaag tggaccaatg ccgacatcag tggctcagac agttgtccag aaggaaagtg     2100

gcctgcagca cacccgaaag atgctgcatg ttggtgaccc aagtgtgaaa aagacagcca     2160

tctcgctgct gaggaatctg tcccggaatc tttctctgca gaatgaaatt gccaaagaaa     2220

ctctccctga tttggtttcc atcattcctg acacagtccc gagtactgac cttctcattg     2280

aaactacagc ctctgcctgt tacacattga acaacataat ccaaaacagt taccagaatg     2340

cacgcgacct tctaaacacc gggggcatcc agaaaattat ggccattagt gcaggcgatg     2400

cctatgcctc caacaaagca agtaaagctg cttccgtcct tctgtattct ctgtgggcac     2460

acacggaact gcatcatgcc tacaagaagg ctcagtttaa gaagacagat tttgtcaaca     2520

gccggactgc caaagcctac cactccctta aagactgagg aaaatgacaa agtattctcg     2580

gctgcaaaaa tccccaaagg aaaacaccta tttttctact acccagccca agaaacctca     2640

aaagcatgcc ttgtttctat ccttctctat ttccgtggtc ccctgaatcc agaaaacaaa     2700

tagaacataa ttttatgagt cttccagaag acctttgcaa gtttgccacc agtagatacc     2760

ggcc                                                                  2764


<210>  2
<211>  837
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ala Pro Gly Ala Pro Ala Glu Tyr Gly Tyr Ile Arg Thr Val 
1               5                   10                  15      


Leu Gly Gln Gln Ile Leu Gly Gln Leu Asp Ser Ser Ser Leu Ala Leu 
            20                  25                  30          


Pro Ser Glu Ala Lys Leu Lys Leu Ala Gly Ser Ser Gly Arg Gly Gly 
        35                  40                  45              


Gln Thr Val Lys Ser Leu Arg Ile Gln Glu Gln Val Gln Gln Thr Leu 
    50                  55                  60                  


Ala Arg Lys Gly Arg Ser Ser Val Gly Asn Gly Asn Leu His Arg Thr 
65                  70                  75                  80  


Ser Ser Val Pro Glu Tyr Val Tyr Asn Leu His Leu Val Glu Asn Asp 
                85                  90                  95      


Phe Val Gly Gly Arg Ser Pro Val Pro Lys Thr Tyr Asp Met Leu Lys 
            100                 105                 110         


Ala Gly Thr Thr Ala Thr Tyr Glu Gly Arg Trp Gly Arg Gly Thr Ala 
        115                 120                 125             


Gln Tyr Ser Ser Gln Lys Ser Val Glu Glu Arg Ser Leu Arg His Pro 
    130                 135                 140                 


Leu Arg Arg Leu Glu Ile Ser Pro Asp Ser Ser Pro Glu Arg Ala His 
145                 150                 155                 160 


Tyr Thr His Ser Asp Tyr Gln Tyr Ser Gln Arg Ser Gln Ala Gly His 
                165                 170                 175     


Thr Leu His His Gln Glu Ser Arg Arg Ala Ala Leu Leu Val Pro Pro 
            180                 185                 190         


Arg Tyr Ala Arg Ser Glu Ile Val Gly Val Ser Arg Ala Gly Thr Thr 
        195                 200                 205             


Ser Arg Gln Arg His Phe Asp Thr Tyr His Arg Gln Tyr Gln His Gly 
    210                 215                 220                 


Ser Val Ser Asp Thr Val Phe Asp Ser Ile Pro Ala Asn Pro Ala Leu 
225                 230                 235                 240 


Leu Thr Tyr Pro Arg Pro Gly Thr Ser Arg Ser Met Gly Asn Leu Leu 
                245                 250                 255     


Glu Lys Glu Asn Tyr Leu Thr Ala Gly Leu Thr Val Gly Gln Val Arg 
            260                 265                 270         


Pro Leu Val Pro Leu Gln Pro Val Thr Gln Asn Arg Ala Ser Arg Ser 
        275                 280                 285             


Ser Trp His Gln Ser Ser Phe His Ser Thr Arg Thr Leu Arg Glu Ala 
    290                 295                 300                 


Gly Pro Ser Val Ala Val Asp Ser Ser Gly Arg Arg Ala His Leu Thr 
305                 310                 315                 320 


Val Gly Gln Ala Ala Ala Gly Gly Ser Gly Asn Leu Leu Thr Glu Arg 
                325                 330                 335     


Ser Thr Phe Thr Asp Ser Gln Leu Gly Asn Ala Asp Met Glu Met Thr 
            340                 345                 350         


Leu Glu Arg Ala Val Ser Met Leu Glu Ala Asp His Met Leu Pro Ser 
        355                 360                 365             


Arg Ile Ser Ala Ala Ala Thr Phe Ile Gln His Glu Cys Phe Gln Lys 
    370                 375                 380                 


Ser Glu Ala Arg Lys Arg Val Asn Gln Leu Arg Gly Ile Leu Lys Leu 
385                 390                 395                 400 


Leu Gln Leu Leu Lys Val Gln Asn Glu Asp Val Gln Arg Ala Val Cys 
                405                 410                 415     


Gly Ala Leu Arg Asn Leu Val Phe Glu Asp Asn Asp Asn Lys Leu Glu 
            420                 425                 430         


Val Ala Glu Leu Asn Gly Val Pro Arg Leu Leu Gln Val Leu Lys Gln 
        435                 440                 445             


Thr Arg Asp Leu Glu Thr Lys Lys Gln Ile Thr Gly Leu Leu Trp Asn 
    450                 455                 460                 


Leu Ser Ser Asn Asp Lys Leu Lys Asn Leu Met Ile Thr Glu Ala Leu 
465                 470                 475                 480 


Leu Thr Leu Thr Glu Asn Ile Ile Ile Pro Phe Ser Gly Trp Pro Glu 
                485                 490                 495     


Gly Asp Tyr Pro Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr 
            500                 505                 510         


Asn Val Thr Gly Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly 
        515                 520                 525             


Arg Lys Ala Met Arg Arg Cys Asp Gly Leu Ile Asp Ser Leu Val His 
    530                 535                 540                 


Tyr Val Arg Gly Thr Ile Ala Asp Tyr Gln Pro Asp Asp Lys Ala Thr 
545                 550                 555                 560 


Glu Asn Cys Val Cys Ile Leu His Asn Leu Ser Tyr Gln Leu Glu Ala 
                565                 570                 575     


Glu Leu Pro Glu Lys Tyr Ser Gln Asn Ile Tyr Ile Gln Asn Arg Asn 
            580                 585                 590         


Ile Gln Thr Asp Asn Asn Lys Ser Ile Gly Cys Phe Gly Ser Arg Ser 
        595                 600                 605             


Arg Lys Val Lys Glu Gln Tyr Gln Asp Val Pro Met Pro Glu Glu Lys 
    610                 615                 620                 


Ser Asn Pro Lys Gly Val Glu Trp Leu Trp His Ser Ile Val Ile Arg 
625                 630                 635                 640 


Met Tyr Leu Ser Leu Ile Ala Lys Ser Val Arg Asn Tyr Thr Gln Glu 
                645                 650                 655     


Ala Ser Leu Gly Ala Leu Gln Asn Leu Thr Ala Gly Ser Gly Pro Met 
            660                 665                 670         


Pro Thr Ser Val Ala Gln Thr Val Val Gln Lys Glu Ser Gly Leu Gln 
        675                 680                 685             


His Thr Arg Lys Met Leu His Val Gly Asp Pro Ser Val Lys Lys Thr 
    690                 695                 700                 


Ala Ile Ser Leu Leu Arg Asn Leu Ser Arg Asn Leu Ser Leu Gln Asn 
705                 710                 715                 720 


Glu Ile Ala Lys Glu Thr Leu Pro Asp Leu Val Ser Ile Ile Pro Asp 
                725                 730                 735     


Thr Val Pro Ser Thr Asp Leu Leu Ile Glu Thr Thr Ala Ser Ala Cys 
            740                 745                 750         


Tyr Thr Leu Asn Asn Ile Ile Gln Asn Ser Tyr Gln Asn Ala Arg Asp 
        755                 760                 765             


Leu Leu Asn Thr Gly Gly Ile Gln Lys Ile Met Ala Ile Ser Ala Gly 
    770                 775                 780                 


Asp Ala Tyr Ala Ser Asn Lys Ala Ser Lys Ala Ala Ser Val Leu Leu 
785                 790                 795                 800 


Tyr Ser Leu Trp Ala His Thr Glu Leu His His Ala Tyr Lys Lys Ala 
                805                 810                 815     


Gln Phe Lys Lys Thr Asp Phe Val Asn Ser Arg Thr Ala Lys Ala Tyr 
            820                 825                 830         


His Ser Leu Lys Asp 
        835         


<210>  3
<211>  2643
<212>  DNA
<213>  artificial

<220>
<223>  PKP2b codon optimized

<400>  3
atggccgccc ccggagcacc tgccgagtat ggctacattc gcaccgtcct gggacagcag       60

attctgggac agctggattc atcaagcctg gccctgcctt ctgaggccaa gctgaagctg      120

gcaggaagct ccggaagggg aggacagacc gtgaagagcc tgagaatcca ggagcaggtg      180

cagcagacac tggcccggaa gggcagatct agcgtgggca acggcaatct gcacaggacc      240

tcctctgtgc cagagtacgt gtataacctg cacctggtgg agaatgactt cgtgggaggc      300

cgcagcccag tgccaaagac atacgatatg ctgaaggccg gcaccacagc aacctatgag      360

ggcaggtggg gaagaggaac agcacagtac agctcccaga agtctgtgga ggagcggagc      420

ctgagacacc ctctgcggag actggagatc agcccagact ctagccctga gagggcacac      480

tatacccact ccgattacca gtattctcag agaagccagg caggacacac actgcaccac      540

caggagagca ggagggccgc cctgctggtg ccacctagat acgcccgctc tgagatcgtg      600

ggcgtgagca gggcaggaac cacatcccgg cagagacact tcgacaccta ccacagacag      660

tatcagcacg gctctgtgag cgacacagtg tttgattcca tccctgccaa cccagccctg      720

ctgacctatc ctcggccagg cacatccaga tctatgggca acctgctgga gaaggagaat      780

tacctgaccg caggcctgac agtgggacag gtgaggcccc tggtgcctct gcagccagtg      840

acccagaatc gggccagcag atcctcttgg caccagagct ccttccactc taccaggaca      900

ctgagggagg caggaccaag cgtggcagtg gactctagcg gccggagagc ccacctgacc      960

gtgggacagg cagcagcagg aggatccggc aacctgctga cagagaggtc cacctttaca     1020

gactctcagc tgggcaatgc cgatatggag atgaccctgg agagggccgt gagcatgctg     1080

gaggcagacc acatgctgcc atccaggatc tctgccgcag ccacattcat ccagcacgag     1140

tgctttcaga agtccgaggc aaggaagagg gtgaaccagc tgaggggcat cctgaagctg     1200

ctgcagctgc tgaaggtgca gaacgaggat gtgcagaggg ccgtgtgcgg cgccctgagg     1260

aatctggtgt tcgaggacaa cgataataag ctggaggtgg cagagctgaa cggagtgcca     1320

aggctgctgc aggtgctgaa gcagacccgc gacctggaga caaagaagca gatcaccgat     1380

cacacagtga acctgcggag cagaaatgga tggcctggag cagtggcaca cgcatgcaat     1440

ccaagcaccc tgggaggaca gggaggaagg atcacaagat ccggcgtgcg ggaccagcct     1500

gatcagcacg gcctgctgtg gaacctgtcc tctaatgaca agctgaagaa cctgatgatc     1560

accgaggccc tgctgaccct gacagagaat atcatcatcc cttttagcgg ctggccagag     1620

ggcgattatc ccaaggccaa cggcctgctg gacttcgata tcttttacaa cgtgaccggc     1680

tgcctgagga atatgagctc cgccggagca gacggaagaa aggccatgag gcgctgtgac     1740

ggcctgatcg attccctggt gcactacgtg cggggcacca tcgccgatta tcagcccgac     1800

gataaggcca cagagaactg cgtgtgcatc ctgcacaatc tgtcttatca gctggaggcc     1860

gagctgcctg agaagtacag ccagaacatc tatatccaga acagaaatat ccagaccgac     1920

aacaataaga gcatcggctg cttcggcagc aggtcccgca aggtgaagga gcagtaccag     1980

gatgtgccca tgcctgagga gaagtccaat cccaagggcg tggagtggct gtggcactct     2040

atcgtgatca ggatgtatct gagcctgatc gccaagtccg tgcgcaacta cacccaggag     2100

gcatctctgg gcgccctgca gaatctgaca gcaggatctg gaccaatgcc caccagcgtg     2160

gcccagacag tggtgcagaa ggagtccggc ctgcagcaca cccggaagat gctgcacgtg     2220

ggcgacccat ccgtgaagaa gacagccatc tctctgctga ggaacctgag ccgcaatctg     2280

tccctgcaga acgagatcgc caaggagaca ctgcccgatc tggtgagcat catcccagac     2340

accgtgccct ccacagatct gctgatcgag acaacagcct ccgcctgtta caccctgaac     2400

aatatcatcc agaactctta tcagaatgcc cgggacctgc tgaacacagg cggcatccag     2460

aagatcatgg caatctccgc cggcgatgca tacgcatcta ataaggccag caaggccgcc     2520

tccgtgctgc tgtattctct gtgggcacac accgagctgc accacgcata caagaaggcc     2580

cagtttaaga agactgattt cgtgaatagc agaacagcca aagcctacca cagcctgaag     2640

gac                                                                   2643


<210>  4
<211>  881
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Pro Gly Ala Pro Ala Glu Tyr Gly Tyr Ile Arg Thr Val 
1               5                   10                  15      


Leu Gly Gln Gln Ile Leu Gly Gln Leu Asp Ser Ser Ser Leu Ala Leu 
            20                  25                  30          


Pro Ser Glu Ala Lys Leu Lys Leu Ala Gly Ser Ser Gly Arg Gly Gly 
        35                  40                  45              


Gln Thr Val Lys Ser Leu Arg Ile Gln Glu Gln Val Gln Gln Thr Leu 
    50                  55                  60                  


Ala Arg Lys Gly Arg Ser Ser Val Gly Asn Gly Asn Leu His Arg Thr 
65                  70                  75                  80  


Ser Ser Val Pro Glu Tyr Val Tyr Asn Leu His Leu Val Glu Asn Asp 
                85                  90                  95      


Phe Val Gly Gly Arg Ser Pro Val Pro Lys Thr Tyr Asp Met Leu Lys 
            100                 105                 110         


Ala Gly Thr Thr Ala Thr Tyr Glu Gly Arg Trp Gly Arg Gly Thr Ala 
        115                 120                 125             


Gln Tyr Ser Ser Gln Lys Ser Val Glu Glu Arg Ser Leu Arg His Pro 
    130                 135                 140                 


Leu Arg Arg Leu Glu Ile Ser Pro Asp Ser Ser Pro Glu Arg Ala His 
145                 150                 155                 160 


Tyr Thr His Ser Asp Tyr Gln Tyr Ser Gln Arg Ser Gln Ala Gly His 
                165                 170                 175     


Thr Leu His His Gln Glu Ser Arg Arg Ala Ala Leu Leu Val Pro Pro 
            180                 185                 190         


Arg Tyr Ala Arg Ser Glu Ile Val Gly Val Ser Arg Ala Gly Thr Thr 
        195                 200                 205             


Ser Arg Gln Arg His Phe Asp Thr Tyr His Arg Gln Tyr Gln His Gly 
    210                 215                 220                 


Ser Val Ser Asp Thr Val Phe Asp Ser Ile Pro Ala Asn Pro Ala Leu 
225                 230                 235                 240 


Leu Thr Tyr Pro Arg Pro Gly Thr Ser Arg Ser Met Gly Asn Leu Leu 
                245                 250                 255     


Glu Lys Glu Asn Tyr Leu Thr Ala Gly Leu Thr Val Gly Gln Val Arg 
            260                 265                 270         


Pro Leu Val Pro Leu Gln Pro Val Thr Gln Asn Arg Ala Ser Arg Ser 
        275                 280                 285             


Ser Trp His Gln Ser Ser Phe His Ser Thr Arg Thr Leu Arg Glu Ala 
    290                 295                 300                 


Gly Pro Ser Val Ala Val Asp Ser Ser Gly Arg Arg Ala His Leu Thr 
305                 310                 315                 320 


Val Gly Gln Ala Ala Ala Gly Gly Ser Gly Asn Leu Leu Thr Glu Arg 
                325                 330                 335     


Ser Thr Phe Thr Asp Ser Gln Leu Gly Asn Ala Asp Met Glu Met Thr 
            340                 345                 350         


Leu Glu Arg Ala Val Ser Met Leu Glu Ala Asp His Met Leu Pro Ser 
        355                 360                 365             


Arg Ile Ser Ala Ala Ala Thr Phe Ile Gln His Glu Cys Phe Gln Lys 
    370                 375                 380                 


Ser Glu Ala Arg Lys Arg Val Asn Gln Leu Arg Gly Ile Leu Lys Leu 
385                 390                 395                 400 


Leu Gln Leu Leu Lys Val Gln Asn Glu Asp Val Gln Arg Ala Val Cys 
                405                 410                 415     


Gly Ala Leu Arg Asn Leu Val Phe Glu Asp Asn Asp Asn Lys Leu Glu 
            420                 425                 430         


Val Ala Glu Leu Asn Gly Val Pro Arg Leu Leu Gln Val Leu Lys Gln 
        435                 440                 445             


Thr Arg Asp Leu Glu Thr Lys Lys Gln Ile Thr Asp His Thr Val Asn 
    450                 455                 460                 


Leu Arg Ser Arg Asn Gly Trp Pro Gly Ala Val Ala His Ala Cys Asn 
465                 470                 475                 480 


Pro Ser Thr Leu Gly Gly Gln Gly Gly Arg Ile Thr Arg Ser Gly Val 
                485                 490                 495     


Arg Asp Gln Pro Asp Gln His Gly Leu Leu Trp Asn Leu Ser Ser Asn 
            500                 505                 510         


Asp Lys Leu Lys Asn Leu Met Ile Thr Glu Ala Leu Leu Thr Leu Thr 
        515                 520                 525             


Glu Asn Ile Ile Ile Pro Phe Ser Gly Trp Pro Glu Gly Asp Tyr Pro 
    530                 535                 540                 


Lys Ala Asn Gly Leu Leu Asp Phe Asp Ile Phe Tyr Asn Val Thr Gly 
545                 550                 555                 560 


Cys Leu Arg Asn Met Ser Ser Ala Gly Ala Asp Gly Arg Lys Ala Met 
                565                 570                 575     


Arg Arg Cys Asp Gly Leu Ile Asp Ser Leu Val His Tyr Val Arg Gly 
            580                 585                 590         


Thr Ile Ala Asp Tyr Gln Pro Asp Asp Lys Ala Thr Glu Asn Cys Val 
        595                 600                 605             


Cys Ile Leu His Asn Leu Ser Tyr Gln Leu Glu Ala Glu Leu Pro Glu 
    610                 615                 620                 


Lys Tyr Ser Gln Asn Ile Tyr Ile Gln Asn Arg Asn Ile Gln Thr Asp 
625                 630                 635                 640 


Asn Asn Lys Ser Ile Gly Cys Phe Gly Ser Arg Ser Arg Lys Val Lys 
                645                 650                 655     


Glu Gln Tyr Gln Asp Val Pro Met Pro Glu Glu Lys Ser Asn Pro Lys 
            660                 665                 670         


Gly Val Glu Trp Leu Trp His Ser Ile Val Ile Arg Met Tyr Leu Ser 
        675                 680                 685             


Leu Ile Ala Lys Ser Val Arg Asn Tyr Thr Gln Glu Ala Ser Leu Gly 
    690                 695                 700                 


Ala Leu Gln Asn Leu Thr Ala Gly Ser Gly Pro Met Pro Thr Ser Val 
705                 710                 715                 720 


Ala Gln Thr Val Val Gln Lys Glu Ser Gly Leu Gln His Thr Arg Lys 
                725                 730                 735     


Met Leu His Val Gly Asp Pro Ser Val Lys Lys Thr Ala Ile Ser Leu 
            740                 745                 750         


Leu Arg Asn Leu Ser Arg Asn Leu Ser Leu Gln Asn Glu Ile Ala Lys 
        755                 760                 765             


Glu Thr Leu Pro Asp Leu Val Ser Ile Ile Pro Asp Thr Val Pro Ser 
    770                 775                 780                 


Thr Asp Leu Leu Ile Glu Thr Thr Ala Ser Ala Cys Tyr Thr Leu Asn 
785                 790                 795                 800 


Asn Ile Ile Gln Asn Ser Tyr Gln Asn Ala Arg Asp Leu Leu Asn Thr 
                805                 810                 815     


Gly Gly Ile Gln Lys Ile Met Ala Ile Ser Ala Gly Asp Ala Tyr Ala 
            820                 825                 830         


Ser Asn Lys Ala Ser Lys Ala Ala Ser Val Leu Leu Tyr Ser Leu Trp 
        835                 840                 845             


Ala His Thr Glu Leu His His Ala Tyr Lys Lys Ala Gln Phe Lys Lys 
    850                 855                 860                 


Thr Asp Phe Val Asn Ser Arg Thr Ala Lys Ala Tyr His Ser Leu Lys 
865                 870                 875                 880 


Asp 
    


<210>  5
<211>  600
<212>  DNA
<213>  Homo sapiens

<400>  5
gtcatggaga agacccacct tgcagatgtc ctcactgggg ctggcagagc cggcaacctg       60

cctaaggctg ctcagtccat taggagccag tagcctggaa gatgtcttta cccccagcat      120

cagttcaagt ggagcagcac ataactcttg ccctctgcct tccaagattc tggtgctgag      180

acttatggag tgtcttggag gttgccttct gccccccaac cctgctccca gctggccctc      240

ccaggcctgg gttgctggcc tctgctttat caggattctc aagagggaca gctggtttat      300

gttgcatgac tgttccctgc atatctgctc tggttttaaa tagcttatct gagcagctgg      360

aggaccacat gggcttatat ggcgtggggt acatgttcct gtagccttgt ccctggcacc      420

tgccaaaata gcagccaaca ccccccaccc ccaccgccat ccccctgccc cacccgtccc      480

ctgtcgcaca ttcctccctc cgcagggctg gctcaccagg ccccagccca catgcctgct      540

taaagccctc tccatcctct gcctcaccca gtccccgctg agactgagca gacgcctcca      600


<210>  6
<211>  8383
<212>  DNA
<213>  artificial

<220>
<223>  Exemplary vector expressing PKP2b

<400>  6
ggcactgggc aggtaagtat caaggttaca agacaggttt aaggagacca atagaaactg       60

ggcttgtcga gacagagaag actcttgcgt ttctgatagg cacctattgg tcttactgac      120

atccactttg cctttctctc cacaggtgtc cactcccagt tcaattacag ctcttaaggc      180

tagagtactt aatacgactc actataggct agcggtaccg gtcgccacca tggactacaa      240

agaccatgac ggtgattata aagatcatga catcgattac aaggatgacg atgacaagct      300

tggtaccgag ctcggatcca tggccgcccc cggagcacct gccgagtatg gctacattcg      360

caccgtcctg ggacagcaga ttctgggaca gctggattca tcaagcctgg ccctgccttc      420

tgaggccaag ctgaagctgg caggaagctc cggaagggga ggacagaccg tgaagagcct      480

gagaatccag gagcaggtgc agcagacact ggcccggaag ggcagatcta gcgtgggcaa      540

cggcaatctg cacaggacct cctctgtgcc agagtacgtg tataacctgc acctggtgga      600

gaatgacttc gtgggaggcc gcagcccagt gccaaagaca tacgatatgc tgaaggccgg      660

caccacagca acctatgagg gcaggtgggg aagaggaaca gcacagtaca gctcccagaa      720

gtctgtggag gagcggagcc tgagacaccc tctgcggaga ctggagatca gcccagactc      780

tagccctgag agggcacact atacccactc cgattaccag tattctcaga gaagccaggc      840

aggacacaca ctgcaccacc aggagagcag gagggccgcc ctgctggtgc cacctagata      900

cgcccgctct gagatcgtgg gcgtgagcag ggcaggaacc acatcccggc agagacactt      960

cgacacctac cacagacagt atcagcacgg ctctgtgagc gacacagtgt ttgattccat     1020

ccctgccaac ccagccctgc tgacctatcc tcggccaggc acatccagat ctatgggcaa     1080

cctgctggag aaggagaatt acctgaccgc aggcctgaca gtgggacagg tgaggcccct     1140

ggtgcctctg cagccagtga cccagaatcg ggccagcaga tcctcttggc accagagctc     1200

cttccactct accaggacac tgagggaggc aggaccaagc gtggcagtgg actctagcgg     1260

ccggagagcc cacctgaccg tgggacaggc agcagcagga ggatccggca acctgctgac     1320

agagaggtcc acctttacag actctcagct gggcaatgcc gatatggaga tgaccctgga     1380

gagggccgtg agcatgctgg aggcagacca catgctgcca tccaggatct ctgccgcagc     1440

cacattcatc cagcacgagt gctttcagaa gtccgaggca aggaagaggg tgaaccagct     1500

gaggggcatc ctgaagctgc tgcagctgct gaaggtgcag aacgaggatg tgcagagggc     1560

cgtgtgcggc gccctgagga atctggtgtt cgaggacaac gataataagc tggaggtggc     1620

agagctgaac ggagtgccaa ggctgctgca ggtgctgaag cagacccgcg acctggagac     1680

aaagaagcag atcaccgatc acacagtgaa cctgcggagc agaaatggat ggcctggagc     1740

agtggcacac gcatgcaatc caagcaccct gggaggacag ggaggaagga tcacaagatc     1800

cggcgtgcgg gaccagcctg atcagcacgg cctgctgtgg aacctgtcct ctaatgacaa     1860

gctgaagaac ctgatgatca ccgaggccct gctgaccctg acagagaata tcatcatccc     1920

ttttagcggc tggccagagg gcgattatcc caaggccaac ggcctgctgg acttcgatat     1980

cttttacaac gtgaccggct gcctgaggaa tatgagctcc gccggagcag acggaagaaa     2040

ggccatgagg cgctgtgacg gcctgatcga ttccctggtg cactacgtgc ggggcaccat     2100

cgccgattat cagcccgacg ataaggccac agagaactgc gtgtgcatcc tgcacaatct     2160

gtcttatcag ctggaggccg agctgcctga gaagtacagc cagaacatct atatccagaa     2220

cagaaatatc cagaccgaca acaataagag catcggctgc ttcggcagca ggtcccgcaa     2280

ggtgaaggag cagtaccagg atgtgcccat gcctgaggag aagtccaatc ccaagggcgt     2340

ggagtggctg tggcactcta tcgtgatcag gatgtatctg agcctgatcg ccaagtccgt     2400

gcgcaactac acccaggagg catctctggg cgccctgcag aatctgacag caggatctgg     2460

accaatgccc accagcgtgg cccagacagt ggtgcagaag gagtccggcc tgcagcacac     2520

ccggaagatg ctgcacgtgg gcgacccatc cgtgaagaag acagccatct ctctgctgag     2580

gaacctgagc cgcaatctgt ccctgcagaa cgagatcgcc aaggagacac tgcccgatct     2640

ggtgagcatc atcccagaca ccgtgccctc cacagatctg ctgatcgaga caacagcctc     2700

cgcctgttac accctgaaca atatcatcca gaactcttat cagaatgccc gggacctgct     2760

gaacacaggc ggcatccaga agatcatggc aatctccgcc ggcgatgcat acgcatctaa     2820

taaggccagc aaggccgcct ccgtgctgct gtattctctg tgggcacaca ccgagctgca     2880

ccacgcatac aagaaggccc agtttaagaa gactgatttc gtgaatagca gaacagccaa     2940

agcctaccac agcctgaagg acctcgaggg atctggagca acaaacttct cactactcaa     3000

acaagcaggt gacgtggagg agaatcccgg gcctaagctt atgaaaacct tcaacatctc     3060

tcagcaggat ctggagctgg tggaggtcgc cactgagaag atcaccatgc tctatgagga     3120

caacaagcac catgtcgggg cggccatcag gaccaagact ggggagatca tctctgctgt     3180

ccacattgaa gcctacattg gcagggtcac tgtctgtgct gaagccattg ccattgggtc     3240

tgctgtgagc aacgggcaga aggactttga caccattgtg gctgtcaggc acccctactc     3300

tgatgaggtg gacagatcca tcagggtggt cagcccctgt ggcatgtgta gagagctgat     3360

ctctgactat gctcctgact gctttgtgct cattgagatg aatggcaagc tggtcaaaac     3420

caccattgag gaactcatcc ccctcaagta caccaggaac taataagcgg ccgcttccct     3480

ttagtgaggg ttaatgcttc gagcagacat gataagatac attgatgagt ttggacaaac     3540

cacaactaga atgcagtgaa aaaaatgctt tatttgtgaa atttgtgatg ctattgcttt     3600

atttgtaacc attataagct gcaataaaca agttaacaac aacaattgca ttcattttat     3660

gtttcaggtt cagggggaga tgtgggaggt tttttaaagc aagtaaaacc tctacaaatg     3720

tggtaaaatc cgataaggga ctagagcatg gctacgtaga taagtagcat ggcgggttaa     3780

tcattaacta caaggaaccc ctagtgatgg agttggccac tccctctctg cgcgctcgct     3840

cgctcactga ggccgggcga ccaaaggtcg cccgacgccc gggctttgcc cgggcggcct     3900

cagtgagcga gcgagcgcgc cagctggcgt aatagcgaag aggcccgcac cgatcgccct     3960

tcccaacagt tgcgcagcct gaatggcgaa tggaattcca gacgattgag cgtcaaaatg     4020

taggtatttc catgagcgtt tttccgttgc aatggctggc ggtaatattg ttctggatat     4080

taccagcaag gccgatagtt tgagttcttc tactcaggca agtgatgtta ttactaatca     4140

aagaagtatt gcgacaacgg ttaatttgcg tgatggacag actcttttac tcggtggcct     4200

cactgattat aaaaacactt ctcaggattc tggcgtaccg ttcctgtcta aaatcccttt     4260

aatcggcctc ctgtttagct cccgctctga ttctaacgag gaaagcacgt tatacgtgct     4320

cgtcaaagca accatagtac gcgccctgta gcggcgcatt aagcgcggcg ggtgtggtgg     4380

ttacgcgcag cgtgaccgct acacttgcca gcgccctagc gcccgctcct ttcgctttct     4440

tcccttcctt tctcgccacg ttcgccggct ttccccgtca agctctaaat cgggggctcc     4500

ctttagggtt ccgatttagt gctttacggc acctcgaccc caaaaaactt gattagggtg     4560

atggttcacg tagtgggcca tcgccctgat agacggtttt tcgccctttg acgttggagt     4620

ccacgttctt taatagtgga ctcttgttcc aaactggaac aacactcaac cctatctcgg     4680

tctattcttt tgatttataa gggattttgc cgatttcggc ctattggtta aaaaatgagc     4740

tgatttaaca aaaatttaac gcgaatttta acaaaatatt aacgtctaca atttaaatat     4800

ttgcttatac aatcttcctg tttttggggc ttttctgatt atcaaccggg gtacatatga     4860

ttgacatgct agttttacga ttaccgttca tcgattctct tgtttgctcc agactctcag     4920

gcaatgacct gatagccttt gtagagacct ctcaaaaata gctaccctct ccggcatgaa     4980

tttatcagct agaacggttg aatatcatat tgatggtgat ttgactgtct ccggcctttc     5040

tcacccgttt gaatctttac ctacacatta ctcaggcatt gcatttaaaa tatatgaggg     5100

ttctaaaaat ttttatcctt gcgttgaaat aaaggcttct cccgcaaaag tattacaggg     5160

tcataatgtt tttggtacaa ccgatttagc tttatgctct gaggctttat tgcttaattt     5220

tgctaattct ttgccttgcc tgtatgattt attggatgtt ggaatcgcct gatgcggtat     5280

tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct cagtacaatc     5340

tgctctgatg ccgcatagtt aagccagccc cgacacccgc caacacccgc tgacgcgccc     5400

tgacgggctt gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc     5460

tgcatgtgtc agaggttttc accgtcatca ccgaaacgcg cgagacgaaa gggcctcgtg     5520

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     5580

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     5640

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     5700

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     5760

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     5820

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     5880

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     5940

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     6000

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     6060

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     6120

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     6180

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     6240

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     6300

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     6360

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     6420

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     6480

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     6540

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     6600

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     6660

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     6720

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     6780

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     6840

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     6900

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     6960

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     7020

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     7080

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     7140

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     7200

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     7260

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     7320

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     7380

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     7440

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     7500

gaagagcgcc caatacgcaa accgcctctc cccgcgcgtt ggccgattca ttaatgcagc     7560

tgcgcgctcg ctcgctcact gaggccgccc gggcaaagcc cgggcgtcgg gcgacctttg     7620

gtcgcccggc ctcagtgagc gagcgagcgc gcagagaggg agtggccaac tccatcacta     7680

ggggttcctt gtagttaatg attaacccgc catgctactt atctacgtag ccatgctcta     7740

gatgtcatgg agaagaccca ccttgcagat gtcctcactg gggctggcag agccggcaac     7800

ctgcctaagg ctgctcagtc cattaggagc cagtagcctg gaagatgtct ttacccccag     7860

catcagttca agtggagcag cacataactc ttgccctctg ccttccaaga ttctggtgct     7920

gagacttatg gagtgtcttg gaggttgcct tctgcccccc aaccctgctc ccagctggcc     7980

ctcccaggcc tgggttgctg gcctctgctt tatcaggatt ctcaagaggg acagctggtt     8040

tatgttgcat gactgttccc tgcatatctg ctctggtttt aaatagctta tctgagcagc     8100

tggaggacca catgggctta tatggcgtgg ggtacatgtt cctgtagcct tgtccctggc     8160

acctgccaaa atagcagcca acacccccca cccccaccgc catccccctg ccccacccgt     8220

cccctgtcgc acattcctcc ctccgcaggg ctggctcacc aggccccagc ccacatgcct     8280

gcttaaagcc ctctccatcc tctgcctcac ccagtccccg ctgagactga gcagacgcct     8340

ccagagctcg gatcctgaga acttcagggt gagtctatgg gac                       8383


