                         б

<110>  ˻ݣҽҩ޹˾
 
<120>  GIPR弰GLP-1ںϵʣԼҩӦ

<130>  2019

<160>  136   

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  1

Lys Ala Ser Gln Asp Val Gly Thr Ala Val Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  2

Trp Ala Tyr Ile Arg His Thr 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  3

Gln Gln Tyr Ser Ser Tyr Pro Trp Thr 
1               5                   


<210>  4
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  4

Arg Pro Ser Glu Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Gln Asn Asn Glu Asp Pro Arg Thr 
1               5                   


<210>  7
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  7

Lys Ala Ser Glu Asp Ile Tyr Asn Arg Phe Ala 
1               5                   10      


<210>  8
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Ala Thr Ser Leu Glu Thr 
1               5           


<210>  9
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  9

Gln Gln Tyr Trp Ser Ile Pro Trp Thr 
1               5                   


<210>  10
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  10

Arg Ala Ser Gln Ser Val Asn Thr Ser Val Tyr Ser Tyr Ile His 
1               5                   10                  15  


<210>  11
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  11

Tyr Ala Ser Asn Leu Glu Ser 
1               5           


<210>  12
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  12

Gln His Ser Trp Asp Phe Pro Tyr Thr 
1               5                   


<210>  13
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  13

Arg Ala Ser Gln Ser Val Asn Thr Ala Val Tyr Ser Tyr Ile His 
1               5                   10                  15  


<210>  14
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  14

Gln His Ser Phe Asp Phe Pro Tyr Thr 
1               5                   


<210>  15
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  15

Lys Ala Ser Gln Asp Ile Asn Ser Tyr Leu Ser 
1               5                   10      


<210>  16
<211>  6
<212>  PRT
<213>  Mus musculus

<400>  16

Ala Asn Arg Leu Val Asp 
1               5       


<210>  17
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  17

Leu Gln Tyr Asp Glu Phe Pro Phe Thr 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  18

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  19
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  19

Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  20
<211>  13
<212>  PRT
<213>  Mus musculus

<400>  20

Gly Glu Gly Gly Ser Ser Tyr Pro Ala Trp Phe Ala Phe 
1               5                   10              


<210>  21
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  21

Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val Thr 
1               5                   10                  15      


Gly 
    


<210>  22
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  22

Asp Lys Ala Thr Arg Thr Gly Met Gly Phe Phe Tyr His Thr Met Asp 
1               5                   10                  15      


Tyr 
    


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Tyr Thr Phe Ser Arg Tyr Trp Ile Glu 
1               5                   10  


<210>  24
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  24

Glu Ile Leu Pro Gly Ser Asp Ser Pro Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


<210>  25
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  25

Thr Val Val Ala Thr Arg Phe Ala Tyr 
1               5                   


<210>  26
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  27
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  27

Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  28
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe 
1               5                   10  


<210>  29
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  29

Tyr Met Ser Tyr Arg Gly Thr Ala Thr Tyr Asn Pro Phe Leu Lys Ser 
1               5                   10                  15      


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Tyr Asp Tyr Asp Val Pro Arg Phe Pro Tyr 
1               5                   10  


<210>  31
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  31
aaggccagtc aggatgtggg tactgctgta gcc                                    33


<210>  32
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  32
tgggcataca tccggcacac t                                                 21


<210>  33
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  33
cagcaatata gcagctatcc gtggacg                                           27


<210>  34
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  34
agacccagtg aaagtgttga tagttatggc aatagtttta tgcac                       45


<210>  35
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  35
cttgcatcca acctagaatc t                                                 21


<210>  36
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  36
cagcaaaata atgaggatcc tcggacg                                           27


<210>  37
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  37
aaggcaagtg aggacatata taatcggttc gcc                                    33


<210>  38
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  38
gatgcaacca gtttggaaac t                                                 21


<210>  39
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  39
caacagtatt ggagtattcc gtggacg                                           27


<210>  40
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  40
agggccagcc aaagtgtcaa tacatctgtc tatagttata tacac                       45


<210>  41
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  41
tatgcatcca acctagaatc t                                                 21


<210>  42
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  42
caacacagtt gggattttcc ttacacg                                           27


<210>  43
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  43
agagccagcc agtccgtgaa cacagccgtg tactcttata tccac                       45


<210>  44
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  44
cagcacagct tcgatttccc ctacacc                                           27


<210>  45
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  45
aaggcgagtc aggacattaa tagctattta agc                                    33


<210>  46
<211>  18
<212>  DNA
<213>  Mus musculus

<400>  46
gcaaacagat tggtagat                                                     18


<210>  47
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  47
ctacagtatg atgagtttcc attcacg                                           27


<210>  48
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  48
ggattcactt tcagtagcta tgccatgtct                                        30


<210>  49
<211>  45
<212>  DNA
<213>  Mus musculus

<400>  49
tccattagta gtggtggtgc cacctactat ccagacagtg tgaag                       45


<210>  50
<211>  39
<212>  DNA
<213>  Mus musculus

<400>  50
ggcgagggcg gtagtagcta cccggcctgg tttgctttc                              39


<210>  51
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  51
gaaattagta gtggtggtag ttacacctac tatccagaca ctgtgacggg c                51


<210>  52
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  52
gataaggcga ctcgaactgg catgggattt ttttaccata ctatggacta c                51


<210>  53
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  53
ggctacacat tcagtaggta ctggatagag                                        30


<210>  54
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  54
gagattttac ctggaagtga tagtcctaac tacaatgaga agttcaaggg c                51


<210>  55
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  55
acggtagtag ctacaaggtt tgcttac                                           27


<210>  56
<211>  33
<212>  DNA
<213>  Mus musculus

<400>  56
ggctactcaa tcaccagtga ttatgcctgg aac                                    33


<210>  57
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  57
tacataagct acagaggcat cgctacctat aaaccatctc tcaaaagt                    48


<210>  58
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  58
ggggaatacg gccccggcaa ctttgacttc                                        30


<210>  59
<211>  48
<212>  DNA
<213>  Mus musculus

<400>  59
tacatgagct accgtggtac cgcaacgtac aatccatttc tcaaaagt                    48


<210>  60
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  60
tatgattacg acgttccccg gtttccttac                                        30


<210>  61
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  61

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Gly Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Tyr Ile Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Val Gln Ser 
65                  70                  75                  80  


Glu Asp Leu Thr Asp Tyr Phe Cys Gln Gln Tyr Ser Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  62
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  62

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Pro Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  63
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  63

Asn Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Pro Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Thr Ala Asn Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  64
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  64

Asn Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Pro Ser Glu Ser Val Asp Ser Tyr 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  65
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  65

Asp Ile Gln Met Thr Gln Ser Ser Ser Ser Phe Ser Val Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asp Ile Tyr Asn Arg 
            20                  25                  30          


Phe Ala Trp Phe Gln Gln Lys Pro Gly Asn Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Ser Asp Ala Thr Ser Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Lys Asp Tyr Thr Leu Ser Ile Thr Ser Leu Gln Thr 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105             


<210>  66
<211>  112
<212>  PRT
<213>  Mus musculus

<400>  66

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Gly Thr Ile Ser Cys Arg Ala Ser Gln Ser Val Asn Thr Ser 
            20                  25                  30          


Val Tyr Ser Tyr Ile His Trp Tyr Arg Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Gly Glu Asp Ser Ala Thr Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


<210>  67
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  67

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Thr Ala 
            20                  25                  30          


Val Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Asn Tyr Tyr Cys Gln His Ser Phe 
                85                  90                  95      


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  68
<211>  112
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  68

Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Gln Ser Val Asn Thr Ser 
            20                  25                  30          


Val Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Trp 
                85                  90                  95      


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  69
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  69

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Val Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Asn Ser Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105             


<210>  70
<211>  110
<212>  PRT
<213>  ˣHomo sapiens

<400>  70

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ala Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Asn Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Arg Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  71
<211>  110
<212>  PRT
<213>  ˣHomo sapiens

<400>  71

Ser Tyr Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Ala Ile Ser Cys Ser Gly Ser Asn Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val His Trp Tyr Gln Gln Leu Pro Gly Ala Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Asn Asp Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Asn Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Arg Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  72
<211>  121
<212>  PRT
<213>  Mus musculus

<400>  72

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Leu Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Ala Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Phe Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Thr 
                85                  90                  95      


Arg Gly Glu Gly Gly Ser Ser Tyr Pro Ala Trp Phe Ala Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ala 
        115                 120     


<210>  73
<211>  126
<212>  PRT
<213>  Mus musculus

<400>  73

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ser Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Glu Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Ala Thr Arg Thr Gly Met Gly Phe Phe Tyr His Thr 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120                 125     


<210>  74
<211>  126
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  74

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Ser Ser Gly Gly Ser Tyr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  


Thr Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Asp Lys Ala Thr Arg Thr Gly Met Gly Phe Phe Tyr His Thr 
            100                 105                 110         


Met Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125     


<210>  75
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  75

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Asp Ser Pro Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asn Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Phe Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Val Val Ala Thr Arg Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Phe Ala 
        115             


<210>  76
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  76

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Asn Phe Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Leu Thr Val Ser Ser 
        115                 


<210>  77
<211>  119
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  77

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  78
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  78

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Met Ser Tyr Arg Gly Thr Ala Thr Tyr Asn Pro Phe Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Asn Arg Asp Thr Ser Lys Asn Gln Val Phe 
65                  70                  75                  80  


Leu Lys Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Tyr Asp Tyr Asp Val Pro Arg Phe Pro Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Ile Val Ser Ala 
        115                 


<210>  79
<211>  119
<212>  PRT
<213>  ˣHomo sapiens

<400>  79

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Gly Pro Ile Val Gly Ala Pro Thr Asp Tyr Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  80
<211>  119
<212>  PRT
<213>  ˣHomo sapiens

<400>  80

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Lys Ser Tyr 
            20                  25                  30          


Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Gly Ile Ile Pro Thr Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Gly Pro Ile Val Gly Ala Pro Thr Asp Tyr Trp Gly Lys Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  81
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  81
gacattgtga tgacccagtc tcacaaattc atgtccacat cagtaggaga cagggtcaac       60

atcacctgca aggccagtca ggatgtgggt actgctgtag cctggtatca acagaaacca      120

gggcaatctc ctaaactact gatttactgg gcatacatcc ggcacactgg agtccctgat      180

cgcttcacag gcagtggatc tgggacagat ttcactctca ccattagcaa tgtgcagtct      240

gaagacttga cagattattt ctgtcagcaa tatagcagct atccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  82
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  82
aacattgtgc tgacccaatc tccagcttct ttggctgtgt ctctagggca gagggccacc       60

atatcctgca gacccagtga aagtgttgat agttatggca atagttttat gcactggtac      120

cagcagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caccattgat      240

cctgtggagg ctgatgatgc tgcaacctat tactgtcagc aaaataatga ggatcctcgg      300

acgttcggtg gaggcaccaa gctggaaatc aaacgg                                336


<210>  83
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  83
aatatcgtgc tgacccagtc tccagccagc ctggccgtgt ctccaggaca gagggccacc       60

atcacatgca gacctagcga gtccgtggat tcctacggca actctttcat gcactggtat      120

cagcagaagc ccggccagcc ccctaagctg ctgatctacc tggccagcaa tctggagtcc      180

ggagtgcctg caaggttctc tggaagcgga tccggaaccg actttaccct gacaatcaac      240

ccagtggagg ccaacgatac agccaattac tattgtcagc agaacaatga ggacccacgg      300

acctttggcg gaggaacaaa ggtggagatc aagcgt                                336


<210>  84
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  84
aacatcgtgc tgacccagtc cccagactct ctggccgtgt ccctgggaga gagggccaca       60

atcaactgca gaccctctga gagcgtggat agctacggca attccttcat gcactggtat      120

cagcagaagc ctggccagcc ccctaagctg ctgatctacc tggcctctaa tctggagagc      180

ggcgtgccag acaggttctc cggatctgga agcggaaccg acttcaccct gacaatcagc      240

tccctgcagg cagaggacgt ggccgtgtac tattgtcagc agaacaatga ggatccccgg      300

acctttggcg gcggcacaaa ggtggagatc aagcgt                                336


<210>  85
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  85
gacatccaga tgacacaatc ttcatcctcc ttttctgtat ctctaggaga cagagtcacc       60

attacttgca aggcaagtga ggacatatat aatcggttcg cctggtttca gcagaaacca      120

ggaaatgctc ctaggctctt aatatctgat gcaaccagtt tggaaactgg ggttccttca      180

agattcagtg gcagtggatc tggaaaggat tacactctca gcattaccag tcttcagact      240

gaagatgttg ctacttatta ctgtcaacag tattggagta ttccgtggac gttcggtgga      300

ggcaccaagc tggaaatcaa acgg                                             324


<210>  86
<211>  336
<212>  DNA
<213>  Mus musculus

<400>  86
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gaggggcacc       60

atctcatgca gggccagcca aagtgtcaat acatctgtct atagttatat acactggtac      120

cggcagaaac caggtcagcc acccaaactc ctcatcaagt atgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg gggaggattc cgcaacatac tactgtcaac acagttggga ttttccttac      300

acgttcggag gggggaccaa gctggaaata aaacgg                                336


<210>  87
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  87
gacatcgtgc tgacccagtc tccagccagc ctggccgtgt ctccaggaca gagggccacc       60

atcacatgca gagccagcca gtccgtgaac acagccgtgt actcttatat ccactggtac      120

cagcagaagc ctggccagcc ccctaagctg ctgatcaagt atgccagcaa cctggagtcc      180

ggagtgcctg cacggttctc tggaagcgga tccggaaccg acttcaccct gacaatcaat      240

ccagtggagg ccaacgacgc cgccaattac tattgtcagc acagcttcga tttcccctac      300

acctttggcg gcggcacaaa ggtggagatc aagcgt                                336


<210>  88
<211>  336
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  88
gacatcgtgc tgacccagtc ccctgattct ctggccgtgt ccctgggaga gagggcaacc       60

atcaactgca gagcctctca gagcgtgaat acaagcgtgt actcctatat ccactggtac      120

cagcagaagc caggccagcc ccctaagctg ctgatcaagt atgcctctaa cctggagagc      180

ggagtgccag accggttctc cggctctggc agcggcacag acttcaccct gacaatcagc      240

tccctgcagg cagaggacgt ggccgtgtac tattgtcagc actcttggga tttcccctac      300

acctttggcg gcggcacaaa ggtggagatc aagcgt                                336


<210>  89
<211>  324
<212>  DNA
<213>  Mus musculus

<400>  89
gacatcaaga tgacccagtc tccatcttcc gtgtatgcat ctctaggaga gagagtcact       60

atcacttgca aggcgagtca ggacattaat agctatttaa gctggttcca gcagaaacca      120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca      180

aggttcagtg gcagtggatc tgggcaagat tattctctca ccatcagcag cctggagtat      240

gaagatatgg gaatttatta ttgtctacag tatgatgagt ttccattcac gttcggctcg      300

gggacaaagt tggaaatgaa acgg                                             324


<210>  90
<211>  330
<212>  DNA
<213>  ˣHomo sapiens

<400>  90
agctacgtgc tgacccagcc acctagcgcc tccggaacac caggccagag ggtggccatc       60

tcttgcagcg gctccaactc taatatcggc tccaacaccg tgcactggta ccagcagctg      120

ccaggagcag cacccaagct gctgatctat tccaacaatc agcggccttc tggcgtgcca      180

gacagattca gcggctccaa ctctggcaca agcgcctccc tggccatctc tcggctgcag      240

agcgaggacg aggccgatta ctattgtgcc gcctgggacg attctctgaa tggcgtggtg      300

tttggcggcg gcaccaaggt gacagtgctg                                       330


<210>  91
<211>  330
<212>  DNA
<213>  ˣHomo sapiens

<400>  91
agctacgtgc tgacccagcc acctagcgcc tccggaacac caggccagag ggtggccatc       60

tcttgcagcg gctccaactc taatatcggc tccaacaccg tgcactggta tcagcagctg      120

ccaggagcag cacccaagct gctgatctat ggcaacaatg atcggccttc tggcgtgcca      180

gacagattca gcggctccaa ctctggcaca agcgcctccc tggccatctc tcggctgcag      240

agcgaggacg aggccgatta ctattgtgcc gcctgggacg attctctgaa tggcgtggtg      300

tttggcggcg gtaccaaggt gacagtgctg                                       330


<210>  92
<211>  363
<212>  DNA
<213>  Mus musculus

<400>  92
gaagtgaagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgcctgact      120

ccagaaaaaa ggctggagtg ggtcgcatcc attagtagtg gtggtgccac ctactatcca      180

gacagtgtga agggccgatt caccttctcc agagataatg ccaggaacat cctgtacctg      240

caaatgaaca gtctgaggtc tgaggacacg gccatgtatt actgtacaag aggcgagggc      300

ggtagtagct acccggcctg gtttgctttc tggggccaag ggactctggt cactgtctct      360

gca                                                                    363


<210>  93
<211>  378
<212>  DNA
<213>  Mus musculus

<400>  93
gaagtgcagc tggtggagtc tgggggaggc ttagtgaagc ctggagggtc cctgaaactc       60

tcctgtgcag cctctggatt cactttcagt agctatgcca tgtcttgggt tcgccagtct      120

ccagagaaga ggctggagtg ggtcgcagaa attagtagtg gtggtagtta cacctactat      180

ccagacactg tgacgggccg attcaccatc tccagagaca atgccaagaa caccctgtac      240

ctggaaatga gcagtctgag gtctgaggac acggccatgt attactgtgt aagggataag      300

gcgactcgaa ctggcatggg atttttttac catactatgg actactgggg tcaaggaacc      360

tcagtcaccg tctcctca                                                    378


<210>  94
<211>  378
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  94
gaggtgcagc tggtggagtc tggaggagga ctggtgaagc caggaggaag cctgaggctg       60

tcctgcgcag cctctggctt cacctttagc tcctacgcca tgagctgggt gaggcaggca      120

ccaggcaagg gactggagtg ggtggccgag atctctagcg gcggctccta cacctactat      180

cctgacaccg tgacaggccg gttcacaatc agcagagata acgccaagaa ttccctgtat      240

ctgcagatga actctctgcg ggccgaggac accgccgtgt actattgcgt gcgggataag      300

gccacccgca caggcatggg cttcttttac cacacaatgg actattgggg ccagggcacc      360

ctggtgacag tgtcctct                                                    378


<210>  95
<211>  354
<212>  DNA
<213>  Mus musculus

<400>  95
caggttcaac tgcagcagtc tggagctgag ctgatgaagc ctggggcctc agtgaagata       60

tcctgcaagg ctactggcta cacattcagt aggtactgga tagagtggat aaagcagagg      120

cctggacatg gccttgagtg gattggagag attttacctg gaagtgatag tcctaactac      180

aatgagaagt tcaagggcaa ggccacattc actgcaaata catcctccaa cacagcctac      240

atgcaactca gcagcctgac atttgaggac tctgccgtct attactgtgc aagaacggta      300

gtagctacaa ggtttgctta ctggggccaa gggactctgg tcactgtctt tgca            354


<210>  96
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  96
gatgtgcagc ttcaggagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttcctggaa acaaagtgga gtggatgggc tacataagct acagaggcat cgctacctat      180

aaaccatctc tcaaaagtcg aatctctatc actcgagaca catccaagaa ccagttcttc      240

ctgaacttta attctgtgac tactgaggac acagccacat attactgtgt aagaggggaa      300

tacggccccg gcaactttga cttctggggc caaggcacca ctctcacagt ctcctca         357


<210>  97
<211>  357
<212>  DNA
<213>  ˹

<220>
<223>  ϳɹ

<400>  97
caggtgcagc tgcaggagtc cggaccagga ctggtgaagc caagccagac cctgtccctg       60

acctgcacag tgtccggcta ctctatcaca agcgattatg cctggaactg gatcaggcag      120

ccacctggca agggagtgga gtggatgggc tacatctcct atcgcggcat cgccacctac      180

aagccttccc tgaagtctcg gatcaccatc tctagagaca caagcaagaa ccagttctct      240

ctgaagctga gctccgtgac cgccgccgat acagccgtgt actattgcgt gcggggcgag      300

tatggccccg gcaatttcga cttttggggc cagggcacca cagtgacagt gtctagc         357


<210>  98
<211>  357
<212>  DNA
<213>  Mus musculus

<400>  98
gatgtgcagc ttcaagagtc gggacctggc ctggtgaaac cttctcagtc tctgtccctc       60

acctgcactg tcactggcta ctcaatcacc agtgattatg cctggaactg gatccggcag      120

tttccaggaa acaaactgga gtggatgggc tacatgagct accgtggtac cgcaacgtac      180

aatccatttc tcaaaagtcg aatctctatc aatcgggaca catccaagaa ccaggtcttc      240

ctgaagttga attctgtgac tactgaggac acagccacat attactgtgc aagttatgat      300

tacgacgttc cccggtttcc ttactggggc caagggactc tggtcattgt ttctgca         357


<210>  99
<211>  357
<212>  DNA
<213>  ˣHomo sapiens

<400>  99
caggtgcagc tgcagcagag cggagcagag gtgaagaagc caggaagctc cgtgaaggtg       60

tcctgcaagg cctctggcgg caccttctct agctacgcca tctcctgggt gcggcaggca      120

ccaggacagg gactggagtg gatgggagga atcatcccca ccttcggcac agccaactac      180

gcccagaagt ttcagggccg ggtgaccatc acagccgacg agtctaccag cacagcctat      240

atggagctgt cctctctgag atctgaggat accgccgtgt actattgtgc acagggacca      300

atcgtgggag cacctacaga ctattggggc aagggcaccc tggtgacagt gagctcc         357


<210>  100
<211>  357
<212>  DNA
<213>  ˣHomo sapiens

<400>  100
caggtgcagc tgcagcagag cggagcagag gtgaagaagc caggaagctc cgtgaaggtg       60

tcctgcaagg cctctggcgg caccttcaag agctacgcca tctcctgggt gcggcaggca      120

ccaggacagg gactggagtg gatgggagga atcatcccca ccttcggcac agccaactac      180

gcccagaagt ttcagggccg ggtgaccatc acagccgacg agtctaccag cacagcctat      240

atggagctgt cctctctgag atctgaggat accgccgtgt actattgtgc acagggacca      300

atcgtgggag cacctacaga ctattggggc aagggcaccc tggtgacagt gagctcc         357

 
<210>  101
<211>  106
<212>  PRT
<213>  ˣHomo sapiens

<400>  101

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105     


<210>  102
<211>  106
<212>  PRT
<213>  ˣHomo sapiens

<400>  102

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  103
<211>  326
<212>  PRT
<213>  ˣHomo sapiens

<220>
<221> MISC_FEATURE
<222> (131)..(131)
<223> 131λXaaΪMetTyr

<220>
<221> MISC_FEATURE
<222> (133)..(133)
<223> 133λXaaΪSerThr

<220>
<221> MISC_FEATURE
<222> (135)..(135)
<223> 135λXaaΪThrGlu

<220>
<221> MISC_FEATURE
<222> (307)..(307)
<223> 307λXaaΪMetLeu

<220>
<221> MISC_FEATURE
<222> (313)..(313)
<223> 313λXaaΪAsnSer

<220>
<221> MISC_FEATURE
<222> (326)..(326)
<223> 326λXaaΪLys߲

<400>  103

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
        115                 120                 125             


Thr Leu Xaa Ile Xaa Arg Xaa Pro Glu Val Thr Cys Val Val Val Asp 
    130                 135                 140                 


Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly 
145                 150                 155                 160 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn 
                165                 170                 175     


Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp 
            180                 185                 190         


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro 
        195                 200                 205             


Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu 
    210                 215                 220                 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
225                 230                 235                 240 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
                245                 250                 255     


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
            260                 265                 270         


Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
        275                 280                 285             


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
    290                 295                 300                 


Ser Val Xaa His Glu Ala Leu His Xaa His Tyr Thr Gln Lys Ser Leu 
305                 310                 315                 320 


Ser Leu Ser Pro Gly Xaa 
                325     


<210>  104
<211>  327
<212>  PRT
<213>  ˣHomo sapiens

<220>
<221> MISC_FEATURE
<222> (132)..(132)
<223> 132λXaaΪMetTyr

<220>
<221> MISC_FEATURE
<222> (134)..(134)
<223> 134λXaaΪSerThr

<220>
<221> MISC_FEATURE
<222> (136)..(136)
<223> 136λXaaΪThrGlu

<220>
<221> MISC_FEATURE
<222> (308)..(308)
<223> 308λXaaΪMetLeu

<220>
<221> MISC_FEATURE
<222> (314)..(314)
<223> 314λXaaΪAsnSer

<220>
<221> MISC_FEATURE
<222> (327)..(327)
<223> 327λXaaΪLys߲

<400>  104

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro 
            100                 105                 110         


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Xaa Ile Xaa Arg Xaa Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Xaa His Glu Ala Leu His Xaa His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Xaa 
                325         


<210>  105
<211>  29
<212>  PRT
<213>  ˣHomo sapiens

<400>  105

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  106

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  107
<211>  22
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  107

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe 
            20          


<210>  108
<211>  23
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  108

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile 
            20              


<210>  109
<211>  24
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  109

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala 
            20                  


<210>  110
<211>  10
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  110

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  111
<211>  15
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  111

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  112
<211>  20
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  112

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  113
<211>  466
<212>  PRT
<213>  ˣHomo sapiens

<400>  113

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Gly Leu Ser Leu Cys 
1               5                   10                  15      


Gly Leu Leu Leu Gln Arg Ala Glu Thr Gly Ser Lys Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Ala Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asp Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Arg Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Met Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Ala Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Leu Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Val Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Phe Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Ser Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Ser Arg Glu Leu Glu Ser 
    450                 455                 460                 


Tyr Cys 
465     


<210>  114
<211>  1401
<212>  DNA
<213>  ˣHomo sapiens

<400>  114
atgactacct ctccgatcct gcagctgctg ctcgggctct cactgtgcgg gctgctgctc       60

cagagggcgg agacaggctc taaggggcag actgcggggg agctgtacca gcgctgggaa      120

cggtaccgca gggagtgcca ggagaccttg gcagccgcgg aaccgccttc aggcctcgcc      180

tgtaacgggt ccttcgatat gtacgtctgc tgggactatg ctgcacccaa tgccactgcc      240

cgtgcgtcct gcccctggta cctgccctgg caccaccatg tggctgcagg tttcgtcctc      300

cgccagtgtc ggagtgatgg ccaatgggga ctttggagag accatacaca atgtgagaac      360

ccagagaaga atgaggcctt tctggaccaa aggctcatct tggagcggtt gcaggtcatg      420

tacactgtcg gctactccct gtctctcgcc acactgctgc tagccctgct catcttgagt      480

ttgttcaggc ggctacattg cactagaaac tatatccaca tcaacctgtt cacgtctttc      540

atgctgcgag ctgcggccat tctcagccga gaccgtctgc tacctcgacc tggcccctac      600

cttggggacc aggcccttgc gctgtggaac caggccctcg ctgcctgccg cacggcccag      660

atcgtgaccc agtactgcgt gggtgccaac tacacgtggc tgctggtgga gggcgtctac      720

ctgcacagtc tcctggtgct cgtgggaggc tccgaggagg gccacttccg ctactacctg      780

ctcctcggct ggggggcccc cgcgcttttc gtcattccct gggtgatcgt caggtacctg      840

tacgagaaca cgcagtgctg ggagcgcaac gaagtcaagg ccatttggtg gattatacgg      900

acccccatcc tcatgaccat cttgattaat ttcctcattt ttatccgcat tcttggcatt      960

ctcctgtcca agctgaggac acggcaaatg cgctgccggg attaccgcgt gaggctggct     1020

cgctccacgc tgacgctggt gcccctgctg ggtgtccacg aggtggtgtt tgctcccgtg     1080

acagaggaac aggcccgggg cgccctgcgt ttcgccaagc tcggctttga gatcttcctc     1140

agctccttcc agggcttcct ggtcagcgtc ctctactgct tcatcaacaa ggaggtgcag     1200

tcggagatcc gccgtggctg gcaccactgc cgcctgcgcc gcagcctggg cgaggagcaa     1260

cgccagctcc cggagcgcgc cttccgggcc ctgccctccg gctccggccc gggcgaggtc     1320

cccaccagcc gcggcttgtc ctcggggacc ctcccagggc ctgggaatga ggccagccgg     1380

gagttggaaa gttactgcta g                                               1401


<210>  115
<211>  466
<212>  PRT
<213>  Macaca mulatta

<400>  115

Met Thr Thr Ser Pro Ile Leu Gln Leu Leu Leu Arg Leu Ser Leu Trp 
1               5                   10                  15      


Gly Leu Leu Leu Arg Arg Ala Glu Thr Gly Ser Glu Gly Gln Thr Ala 
            20                  25                  30          


Gly Glu Leu Tyr Gln Arg Trp Glu Arg Tyr Arg Arg Glu Cys Gln Glu 
        35                  40                  45              


Thr Leu Ala Thr Ala Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser 
    50                  55                  60                  


Phe Asp Met Tyr Val Cys Trp Asn Tyr Ala Ala Pro Asn Ala Thr Ala 
65                  70                  75                  80  


Arg Ala Ser Cys Pro Trp Tyr Leu Pro Trp His His His Val Ala Ala 
                85                  90                  95      


Gly Phe Val Leu Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Leu Trp 
            100                 105                 110         


Arg Asp His Thr Gln Cys Glu Asn Pro Glu Lys Asn Glu Ala Phe Leu 
        115                 120                 125             


Asp Gln Arg Leu Ile Leu Glu Arg Leu Gln Val Met Tyr Thr Val Gly 
    130                 135                 140                 


Tyr Ser Leu Ser Leu Ala Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser 
145                 150                 155                 160 


Leu Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Ile Asn Leu 
                165                 170                 175     


Phe Thr Ser Phe Thr Leu Arg Ala Ala Ala Ile Leu Ser Arg Asp Arg 
            180                 185                 190         


Leu Leu Pro Arg Pro Gly Pro Tyr Leu Gly Asp Gln Ala Leu Val Leu 
        195                 200                 205             


Trp Asn Gln Ala Leu Ala Ala Cys Arg Thr Ala Gln Ile Val Thr Gln 
    210                 215                 220                 


Tyr Cys Val Gly Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr 
225                 230                 235                 240 


Leu His Ser Leu Leu Val Ile Val Gly Gly Ser Glu Glu Gly His Phe 
                245                 250                 255     


Arg Tyr Tyr Leu Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile 
            260                 265                 270         


Pro Trp Val Ile Val Arg Tyr Leu Tyr Glu Asn Thr Gln Cys Trp Glu 
        275                 280                 285             


Arg Asn Glu Val Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu 
    290                 295                 300                 


Met Thr Ile Leu Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile 
305                 310                 315                 320 


Leu Leu Ser Lys Leu Arg Thr Arg Gln Met Arg Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Arg Leu Ala Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val 
            340                 345                 350         


His Glu Val Val Phe Ala Pro Val Thr Glu Glu Gln Ala Arg Gly Ala 
        355                 360                 365             


Leu Arg Phe Ala Lys Leu Gly Phe Glu Ile Phe Leu Ser Ser Phe Gln 
    370                 375                 380                 


Gly Leu Leu Val Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln 
385                 390                 395                 400 


Ser Glu Ile Arg Arg Gly Trp His His Cys Arg Leu Arg Arg Ser Leu 
                405                 410                 415     


Gly Glu Glu Gln Arg Gln Leu Pro Glu Arg Ala Phe Arg Ala Leu Pro 
            420                 425                 430         


Ser Gly Ser Gly Pro Gly Glu Val Pro Thr Gly Arg Gly Leu Ser Ser 
        435                 440                 445             


Gly Thr Leu Pro Gly Pro Gly Asn Glu Ala Arg Arg Val Leu Glu Ser 
    450                 455                 460                 


Tyr Cys 
465     


<210>  116
<211>  1398
<212>  DNA
<213>  Macaca mulatta

<400>  116
atgactacct ctccgatcct gcagttgctg ttgcggctct cactgtgggg gctgctgctc       60

cggagggcgg agacaggctc tgaggggcag acggcggggg agctgtacca gcgctgggaa      120

cggtaccgca gggagtgcca ggagaccttg gcaaccgcgg aaccaccttc aggcctcgcc      180

tgtaacgggt ccttcgatat gtacgtctgc tggaactatg ctgcacccaa cgccactgcc      240

cgtgcctcct gcccctggta cctgccctgg caccaccacg tggctgcagg tttcgtcctc      300

cgccagtgtg gcagtgatgg ccagtgggga ctttggagag accacacaca atgtgagaac      360

ccagagaaga atgaggcctt tctggaccaa aggctcatct tggagcggct gcaggtcatg      420

tacaccgtcg gctactccct gtctctcgcc acactgctgc tagccctgct catcttgagc      480

ttgttcaggc gactacattg cactagaaac tatatccaca tcaacctgtt cacgtctttc      540

acactgcgag cggcggcgat tctcagccgg gaccgtctac tgcctcgacc tggcccctac      600

cttggggacc aggcccttgt gctgtggaac caggccctcg ctgcctgccg cacggcccag      660

atcgtgaccc agtactgcgt gggtgccaac tacacgtggc tgctggtgga gggcgtctac      720

ttgcacagtc tcctggtgat cgtgggaggc tccgaggagg gtcacttccg ctactacctg      780

ctcctcggct ggggggcccc cgcgcttttc gtcattccct gggtgatcgt caggtacctg      840

tacgagaaca cgcagtgctg ggagcgcaac gaagtcaagg ccatttggtg gattatacgg      900

acccccatcc tcatgaccat cttgattaat ttcctcattt ttatccgcat tcttggcatt      960

ctcctgtcca agctgaggac acggcaaatg cgctgccggg attaccggct gaggctggct     1020

cgctccacgc tgacgctggt gcccctgctg ggtgtccacg aggtggtgtt tgctcccgtg     1080

accgaggaac aggcccgggg cgccctgcgc ttcgccaagc tcggctttga gatcttcctc     1140

agctctttcc agggcttgct ggtcagcgtc ctctactgct tcatcaacaa ggaggtgcag     1200

tcggagatcc gccgtggctg gcaccactgc cgcctgcgcc gcagcctggg cgaggagcag     1260

cggcagctcc cggagcgcgc cttccgggcc ctgccctccg gctccggccc cggcgaggtc     1320

cccaccggcc gcggcttgtc ttcggggacc ctcccagggc ctgggaatga ggccagacgg     1380

gtgttggaaa gttactgc                                                   1398


<210>  117
<211>  460
<212>  PRT
<213>  Mus musculus

<400>  117

Met Pro Leu Arg Leu Leu Leu Leu Leu Leu Trp Leu Trp Gly Leu Gln 
1               5                   10                  15      


Trp Ala Glu Thr Asp Ser Glu Gly Gln Thr Thr Thr Gly Glu Leu Tyr 
            20                  25                  30          


Gln Arg Trp Glu His Tyr Gly Gln Glu Cys Gln Lys Met Leu Glu Thr 
        35                  40                  45              


Thr Glu Pro Pro Ser Gly Leu Ala Cys Asn Gly Ser Phe Asp Met Tyr 
    50                  55                  60                  


Ala Cys Trp Asn Tyr Thr Ala Ala Asn Thr Thr Ala Arg Val Ser Cys 
65                  70                  75                  80  


Pro Trp Tyr Leu Pro Trp Phe Arg Gln Val Ser Ala Gly Phe Val Phe 
                85                  90                  95      


Arg Gln Cys Gly Ser Asp Gly Gln Trp Gly Ser Trp Arg Asp His Thr 
            100                 105                 110         


Gln Cys Glu Asn Pro Glu Lys Asn Gly Ala Phe Gln Asp Gln Thr Leu 
        115                 120                 125             


Ile Leu Glu Arg Leu Gln Ile Met Tyr Thr Val Gly Tyr Ser Leu Ser 
    130                 135                 140                 


Leu Thr Thr Leu Leu Leu Ala Leu Leu Ile Leu Ser Leu Phe Arg Arg 
145                 150                 155                 160 


Leu His Cys Thr Arg Asn Tyr Ile His Met Asn Leu Phe Thr Ser Phe 
                165                 170                 175     


Met Leu Arg Ala Ala Ala Ile Leu Thr Arg Asp Gln Leu Leu Pro Pro 
            180                 185                 190         


Leu Gly Pro Tyr Thr Gly Asp Gln Ala Pro Thr Pro Trp Asn Gln Ala 
        195                 200                 205             


Leu Ala Ala Cys Arg Thr Ala Gln Ile Met Thr Gln Tyr Cys Val Gly 
    210                 215                 220                 


Ala Asn Tyr Thr Trp Leu Leu Val Glu Gly Val Tyr Leu His His Leu 
225                 230                 235                 240 


Leu Val Ile Val Gly Arg Ser Glu Lys Gly His Phe Arg Cys Tyr Leu 
                245                 250                 255     


Leu Leu Gly Trp Gly Ala Pro Ala Leu Phe Val Ile Pro Trp Val Ile 
            260                 265                 270         


Val Arg Tyr Leu Arg Glu Asn Thr Gln Cys Trp Glu Arg Asn Glu Val 
        275                 280                 285             


Lys Ala Ile Trp Trp Ile Ile Arg Thr Pro Ile Leu Ile Thr Ile Leu 
    290                 295                 300                 


Ile Asn Phe Leu Ile Phe Ile Arg Ile Leu Gly Ile Leu Val Ser Lys 
305                 310                 315                 320 


Leu Arg Thr Arg Gln Met Arg Cys Pro Asp Tyr Arg Leu Arg Leu Ala 
                325                 330                 335     


Arg Ser Thr Leu Thr Leu Val Pro Leu Leu Gly Val His Glu Val Val 
            340                 345                 350         


Phe Ala Pro Val Thr Glu Glu Gln Val Glu Gly Ser Leu Arg Phe Ala 
        355                 360                 365             


Lys Leu Ala Phe Glu Ile Phe Leu Ser Ser Phe Gln Gly Phe Leu Val 
    370                 375                 380                 


Ser Val Leu Tyr Cys Phe Ile Asn Lys Glu Val Gln Ser Glu Ile Arg 
385                 390                 395                 400 


Gln Gly Trp Arg His Arg Arg Leu Arg Leu Ser Leu Gln Glu Gln Arg 
                405                 410                 415     


Pro Arg Pro His Gln Glu Leu Ala Pro Arg Ala Val Pro Leu Ser Ser 
            420                 425                 430         


Ala Cys Arg Glu Ala Ala Val Gly Asn Ala Leu Pro Ser Gly Met Leu 
        435                 440                 445             


His Val Pro Gly Asp Glu Val Leu Glu Ser Tyr Cys 
    450                 455                 460 


<210>  118
<211>  1380
<212>  DNA
<213>  Mus musculus

<400>  118
atgcccctgc ggttgctgct tctgctgctg tggttgtggg gactccagtg ggcggagaca       60

gactctgagg ggcagaccac cacgggggag ctgtaccagc gctgggagca ctacggccag      120

gagtgccaaa agatgttgga gaccacagaa cctccctcag gcctggcctg taacggttcc      180

ttcgatatgt atgcctgctg gaactacacg gccgccaaca ccactgctcg ggtgtcttgc      240

ccctggtatc tgccctggtt ccgtcaggtg tctgcaggct ttgtcttccg ccagtgtggc      300

agtgatggcc agtggggatc ttggagagac cacactcagt gtgagaatcc agagaagaat      360

ggggcttttc aggaccagac gctgatcctg gagcgcctgc agatcatgta taccgtgggc      420

tactccctgt ccctgacgac tctgctgcta gccctactca tcttaagttt gttcaggcgg      480

ctgcactgca ctcgtaatta cattcacatg aacctgttca cgtctttcat gctgcgggca      540

gcagccatcc tcacccgaga tcagctgctg cctccactgg gtccctacac tggagaccag      600

gcccctaccc cgtggaacca ggccctagct gcctgccgca cggcccagat catgacccaa      660

tattgtgtgg gagccaatta cacctggcta ctggtggagg gtgtttatct gcaccatctg      720

ctggtgatcg tgggacgctc agaaaagggc cacttccgct gctacctgct tcttggctgg      780

ggggcccccg cgcttttcgt cattccctgg gtgatcgtca ggtacctgcg cgagaacaca      840

cagtgctggg agcgcaacga agtcaaagcc atttggtgga tcattcgcac tcccatccta      900

ataaccatct tgatcaattt cctcatcttc atccgcatcc ttggcatcct tgtttcaaag      960

ctgaggacac ggcagatgcg ctgccccgac taccgactaa ggctggctcg ctccacgctg     1020

acactggtgc ccctgctggg tgtccacgag gtggtgtttg cgcctgtgac ggaggaacag     1080

gttgaaggct ccctgcgctt cgccaaactg gcctttgaaa tcttcctaag ttccttccag     1140

ggtttcctgg tgagcgtgct ctactgcttc atcaacaaag aggtgcagtc ggagatccgc     1200

cagggttggc gccaccgccg cctgcgtctc agtcttcaag agcagcgtcc acgtccgcac     1260

caggaactcg ccccccgggc tgtgcctttg agctctgcgt gccgagaagc tgccgttggc     1320

aacgccttgc cctctgggat gctgcatgtg cctggggatg aggtcttgga aagttactgc     1380


<210>  119
<211>  29
<212>  PRT
<213>  ˣHomo sapiens

<400>  119

Gly Lys Val Leu Trp Ala Ile Phe Glu Lys Ala Ala Gln Gly Glu Leu 
1               5                   10                  15      


Tyr Ser Ser Val Asp Ser Thr Phe Thr Gly Glu Ala His 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  120

Gly Lys Val Leu Trp Ala Ile Phe Glu Lys Ala Ala Gln Gly Glu Leu 
1               5                   10                  15      


Tyr Ser Ser Val Asp Ser Thr Phe Thr Gly Glu Gly His 
            20                  25                  


<210>  121
<211>  22
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  121

Phe Glu Lys Ala Ala Gln Gly Glu Leu Tyr Ser Ser Val Asp Ser Thr 
1               5                   10                  15      


Phe Thr Gly Glu Gly His 
            20          


<210>  122
<211>  23
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  122

Ile Phe Glu Lys Ala Ala Gln Gly Glu Leu Tyr Ser Ser Val Asp Ser 
1               5                   10                  15      


Thr Phe Thr Gly Glu Gly His 
            20              


<210>  123
<211>  24
<212>  PRT
<213>  ˹

<220>
<223>  ϳɹ

<400>  123

Ala Ile Phe Glu Lys Ala Ala Gln Gly Glu Leu Tyr Ser Ser Val Asp 
1               5                   10                  15      


Ser Thr Phe Thr Gly Glu Gly His 
            20                  



<210>  124
<211>  327
<212>  PRT
<213>  ˣHomo sapiens

<220>
<221> MISC_FEATURE
<222> (132)..(132)
<223> 132λXaaΪMetTyr

<220>
<221> MISC_FEATURE
<222> (134)..(134)
<223> 134λXaaΪSerThr

<220>
<221> MISC_FEATURE
<222> (136)..(136)
<223> 136λXaaΪThrGlu

<220>
<221> MISC_FEATURE
<222> (308)..(308)
<223> 308λXaaΪMetLeu

<220>
<221> MISC_FEATURE
<222> (314)..(314)
<223> 314λXaaΪAsnSer

<220>
<221> MISC_FEATURE
<222> (327)..(327)
<223> 327λXaaΪLys߲

<400>  124

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            100                 105                 110         


Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        115                 120                 125             


Asp Thr Leu Xaa Ile Xaa Arg Xaa Pro Glu Val Thr Cys Val Val Val 
    130                 135                 140                 


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
145                 150                 155                 160 


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                165                 170                 175     


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            180                 185                 190         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        195                 200                 205             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    210                 215                 220                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
225                 230                 235                 240 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                245                 250                 255     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            260                 265                 270         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        275                 280                 285             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    290                 295                 300                 


Cys Ser Val Xaa His Glu Ala Leu His Xaa His Tyr Thr Gln Lys Ser 
305                 310                 315                 320 


Leu Ser Leu Ser Leu Gly Xaa
                325     


<210>  125
<211>  218
<212>  PRT
<213>  ˣHomo sapiens

<400>  125

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Thr Ala 
            20                  25                  30          


Val Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Asn Tyr Tyr Cys Gln His Ser Phe 
                85                  90                  95      


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  126
<211>  218
<212>  PRT
<213>  ˣHomo sapiens

<400>  126

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Thr Ala 
            20                  25                  30          


Val Tyr Ser Tyr Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn 
65                  70                  75                  80  


Pro Val Glu Ala Asn Asp Ala Ala Asn Tyr Tyr Cys Gln His Ser Phe 
                85                  90                  95      


Asp Phe Pro Tyr Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
        115                 120                 125             


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
    130                 135                 140                 


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
145                 150                 155                 160 


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
                165                 170                 175     


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
            180                 185                 190         


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
        195                 200                 205             


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    210                 215             


<210>  127
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  127

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  128
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  128

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  129
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  129

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His Ser 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  130
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  130

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  131
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  131

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  132
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  132

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
            420                 425                 430         


Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  133
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  133

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  134
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  134

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  135
<211>  445
<212>  PRT
<213>  ˣHomo sapiens

<400>  135

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Val Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Arg Gly Ile Ala Thr Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Glu Tyr Gly Pro Gly Asn Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 


Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Glu Gly Asn Val Phe Ser Cys Ser Val Leu His Glu Ala Leu His 
            420                 425                 430         


Ser His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445 


<210>  136
<211>  262
<212>  PRT
<213>  ˣHomo sapiens

<400>  136

His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Gly Gly 
            20                  25                  30          


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu 
        35                  40                  45              


Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Pro Gly Gln Arg Ala Thr 
    50                  55                  60                  


Ile Thr Cys Arg Ala Ser Gln Ser Val Asn Thr Ala Val Tyr Ser Tyr 
65                  70                  75                  80  


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
                85                  90                  95      


Lys Tyr Ala Ser Asn Leu Glu Ser Gly Val Pro Ala Arg Phe Ser Gly 
            100                 105                 110         


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Pro Val Glu Ala 
        115                 120                 125             


Asn Asp Ala Ala Asn Tyr Tyr Cys Gln His Ser Phe Asp Phe Pro Tyr 
    130                 135                 140                 


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
145                 150                 155                 160 


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
                165                 170                 175     


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
            180                 185                 190         


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
        195                 200                 205             


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
    210                 215                 220                 


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
225                 230                 235                 240 


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
                245                 250                 255     


Phe Asn Arg Gly Glu Cys 
            260         
