                         б

<110>  ҩƣۣ޹˾;ϺҽҩƼ޹˾
 
<120>  һַĿԭϵ׼;

<130>  0130-PA-003

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  16
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 LCDR1

<400>  1

Arg Ser Ser Gln Asn Ile Val His Ser Asn Gly Asn Thr Tyr Leu Gln 
1               5                   10                  15      


<210>  2
<211>  7
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 LCDR2

<400>  2

Lys Val Ser Asn Arg Phe Tyr 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 LCDR3

<400>  3

Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 HCDR1

<400>  4

Gly Phe Asn Ile Ile Asp Thr Tyr Ile His 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 HCDR2

<400>  5

Ser Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp Pro Gln Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  6
<211>  6
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 HCDR3

<400>  6

Thr Thr Ser Met Asp Tyr 
1               5       


<210>  7
<211>  23
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 L-FR1

<400>  7

Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys 
            20              


<210>  8
<211>  15
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 L-FR2

<400>  8

Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr 
1               5                   10                  15  


<210>  9
<211>  32
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 L-FR3

<400>  9

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
1               5                   10                  15      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            20                  25                  30          


<210>  10
<211>  11
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 L-FR4

<400>  10

Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg 
1               5                   10      


<210>  11
<211>  25
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 H-FR1

<400>  11

Glu Val Gln Leu Gln Gln Ser Gly Ala Ala Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser 
            20                  25  


<210>  12
<211>  14
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 H-FR2

<400>  12

Trp Val Gln Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile Gly 
1               5                   10                  


<210>  13
<211>  30
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 H-FR3

<400>  13

Lys Ala Thr Met Thr Ala Asp Lys Ser Ser Asn Ala Ala Tyr Leu Gln 
1               5                   10                  15      


Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile Tyr Tyr Cys 
            20                  25                  30  


<210>  14
<211>  10
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 H-FR4

<400>  14

Trp Gly Gln Gly Thr Ser Val Thr Val Ser 
1               5                   10  


<210>  15
<211>  132
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 VL

<400>  15

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Tyr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Arg Arg 
    130         


<210>  16
<211>  131
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2 VH

<400>  16

Met Lys Cys Ser Trp Val Met Phe Phe Leu Met Ala Val Val Ala Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Ala Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Ile Asp Thr Tyr Ile His Trp Val Gln Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ser Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp 
65                  70                  75                  80  


Pro Gln Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Lys Ser Ser Asn 
                85                  90                  95      


Ala Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        115                 120                 125             


Thr Val Ser 
    130     


<210>  17
<211>  107
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2㶨

<400>  17

Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
        35                  40                  45              


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
65                  70                  75                  80  


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
                85                  90                  95      


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
            100                 105         


<210>  18
<211>  404
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2㶨

<400>  18

Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly Cys Gly Asp 
1               5                   10                  15      


Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe 
            20                  25                  30          


Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu Ser Ser Ser 
        35                  40                  45              


Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr Thr Met Ser 
    50                  55                  60                  


Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln Thr Val Thr 
65                  70                  75                  80  


Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp Lys Lys Leu 
                85                  90                  95      


Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro Pro Cys Lys 
            100                 105                 110         


Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly Pro Ser Val 
        115                 120                 125             


Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile Ser Leu Thr 
    130                 135                 140                 


Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
145                 150                 155                 160 


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
                165                 170                 175     


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg Val Val Ser 
            180                 185                 190         


Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
        195                 200                 205             


Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu Arg Thr Ile 
    210                 215                 220                 


Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr Ile Leu Pro 
225                 230                 235                 240 


Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu Thr Cys Leu 
                245                 250                 255     


Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp Thr Ser Asn 
            260                 265                 270         


Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val Leu Asp Ser 
        275                 280                 285             


Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys Thr Ser Lys 
    290                 295                 300                 


Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His Glu Gly Leu 
305                 310                 315                 320 


Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro Gly Leu Asp 
                325                 330                 335     


Leu Asp Asp Ile Cys Ala Glu Ala Lys Asp Gly Glu Leu Asp Gly Leu 
            340                 345                 350         


Trp Thr Thr Ile Thr Ile Phe Ile Ser Leu Phe Leu Leu Ser Val Cys 
        355                 360                 365             


Tyr Ser Ala Ser Val Thr Leu Phe Lys Val Lys Trp Ile Phe Ser Ser 
    370                 375                 380                 


Val Val Glu Leu Lys Gln Lys Ile Ser Pro Asp Tyr Arg Asn Met Ile 
385                 390                 395                 400 


Gly Gln Gly Ala 
                


<210>  19
<211>  239
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2

<400>  19

Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Leu Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Asn Ile 
        35                  40                  45              


Val His Ser Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Tyr 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Arg Arg Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro 
    130                 135                 140                 


Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp 
                165                 170                 175     


Gly Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys 
        195                 200                 205             


Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys 
    210                 215                 220                 


Thr Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
225                 230                 235                 


<210>  20
<211>  535
<212>  PRT
<213>  ˹УArtificial Sequence

<220>
<223>  Z2

<400>  20

Met Lys Cys Ser Trp Val Met Phe Phe Leu Met Ala Val Val Ala Gly 
1               5                   10                  15      


Val Asn Ser Glu Val Gln Leu Gln Gln Ser Gly Ala Ala Leu Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile 
        35                  40                  45              


Ile Asp Thr Tyr Ile His Trp Val Gln Gln Arg Pro Glu Gln Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Ser Ile Asp Pro Ala Asn Gly Asn Thr Lys Tyr Asp 
65                  70                  75                  80  


Pro Gln Phe Gln Gly Lys Ala Thr Met Thr Ala Asp Lys Ser Ser Asn 
                85                  90                  95      


Ala Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Thr Thr Ser Met Asp Tyr Trp Gly Gln Gly Thr Ser Val 
        115                 120                 125             


Thr Val Ser Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
    130                 135                 140                 


Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val Lys 
145                 150                 155                 160 


Gly Tyr Phe Pro Glu Ser Val Thr Val Thr Trp Asn Ser Gly Ser Leu 
                165                 170                 175     


Ser Ser Ser Val His Thr Phe Pro Ala Leu Leu Gln Ser Gly Leu Tyr 
            180                 185                 190         


Thr Met Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser Gln 
        195                 200                 205             


Thr Val Thr Cys Ser Val Ala His Pro Ala Ser Ser Thr Thr Val Asp 
    210                 215                 220                 


Lys Lys Leu Glu Pro Ser Gly Pro Ile Ser Thr Ile Asn Pro Cys Pro 
225                 230                 235                 240 


Pro Cys Lys Glu Cys His Lys Cys Pro Ala Pro Asn Leu Glu Gly Gly 
                245                 250                 255     


Pro Ser Val Phe Ile Phe Pro Pro Asn Ile Lys Asp Val Leu Met Ile 
            260                 265                 270         


Ser Leu Thr Pro Lys Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
        275                 280                 285             


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
    290                 295                 300                 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Ile Arg 
305                 310                 315                 320 


Val Val Ser Thr Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
                325                 330                 335     


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ser Pro Ile Glu 
            340                 345                 350         


Arg Thr Ile Ser Lys Ile Lys Gly Leu Val Arg Ala Pro Gln Val Tyr 
        355                 360                 365             


Ile Leu Pro Pro Pro Ala Glu Gln Leu Ser Arg Lys Asp Val Ser Leu 
    370                 375                 380                 


Thr Cys Leu Val Val Gly Phe Asn Pro Gly Asp Ile Ser Val Glu Trp 
385                 390                 395                 400 


Thr Ser Asn Gly His Thr Glu Glu Asn Tyr Lys Asp Thr Ala Pro Val 
                405                 410                 415     


Leu Asp Ser Asp Gly Ser Tyr Phe Ile Tyr Ser Lys Leu Asn Met Lys 
            420                 425                 430         


Thr Ser Lys Trp Glu Lys Thr Asp Ser Phe Ser Cys Asn Val Arg His 
        435                 440                 445             


Glu Gly Leu Lys Asn Tyr Tyr Leu Lys Lys Thr Ile Ser Arg Ser Pro 
    450                 455                 460                 


Gly Leu Asp Leu Asp Asp Ile Cys Ala Glu Ala Lys Asp Gly Glu Leu 
465                 470                 475                 480 


Asp Gly Leu Trp Thr Thr Ile Thr Ile Phe Ile Ser Leu Phe Leu Leu 
                485                 490                 495     


Ser Val Cys Tyr Ser Ala Ser Val Thr Leu Phe Lys Val Lys Trp Ile 
            500                 505                 510         


Phe Ser Ser Val Val Glu Leu Lys Gln Lys Ile Ser Pro Asp Tyr Arg 
        515                 520                 525             


Asn Met Ile Gly Gln Gly Ala 
    530                 535 


<210>  21
<211>  396
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>   Z2 VL

<400>  21
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttttgatga cccagactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgtagat ctagtcagaa cattgtacat agtaatggaa acacctattt acaatggtac      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttat      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccgtac      360

acgttcggcg gggggaccaa gctggaaata agacgg                                396


<210>  22
<211>  393
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>   Z2 VH

<400>  22
atgaaatgca gctgggttat gttcttcctg atggcagtgg ttgcaggggt caattcagag       60

gttcagctgc agcagtctgg ggcagcgctt gtgaagccag gggcctcagt caagttgtcc      120

tgcacagcct ctggcttcaa cattatagac acctacatac actgggtgca gcagaggcct      180

gaacagggcc tggaatggat tggaagcatt gatcctgcga atggtaatac taaatatgac      240

ccccagttcc agggcaaggc cactatgaca gcagacaaat cctccaacgc cgcctacctg      300

cagctcagca gcctgacatc tgaggacact gccatctatt actgtactac gtctatggac      360

tactggggtc aaggaacctc agtcaccgtc tct                                   393


<210>  23
<211>  321
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>   Z2 㶨

<400>  23
cgcgcggatg cggcgccgac cgtgagcatt tttccgccga gcagcgaaca gctgaccagc       60

ggcggcgcga gcgtggtgtg ctttctgaac aacttttatc cgaaagatat taacgtgaaa      120

tggaaaattg atggcagcga acgccagaac ggcgtgctga acagctggac cgatcaggat      180

agcaaagata gcacctatag catgagcagc accctgaccc tgaccaaaga tgaatatgaa      240

cgccataaca gctatacctg cgaagcgacc cataaaacca gcaccagccc gattgtgaaa      300

agctttaacc gcaacgaatg c                                                321


<210>  24
<211>  1212
<212>  DNA
<213>  ˹УArtificial Sequence

<220>
<223>   Z2㶨

<400>  24
aaaaccaccc cgccgagcgt gtatccgctg gcgccgggct gcggcgatac caccggcagc       60

agcgtgaccc tgggctgcct ggtgaaaggc tattttccgg aaagcgtgac cgtgacctgg      120

aacagcggca gcctgagcag cagcgtgcat acctttccgg cgctgctgca gagcggcctg      180

tataccatga gcagcagcgt gaccgtgccg agcagcacct ggccgagcca gaccgtgacc      240

tgcagcgtgg cgcatccggc gagcagcacc accgtggata aaaaactgga accgagcggc      300

ccgattagca ccattaaccc gtgcccgccg tgcaaagaat gccataaatg cccggcgccg      360

aacctggaag gcggcccgag cgtgtttatt tttccgccga acattaaaga tgtgctgatg      420

attagcctga ccccgaaagt gacctgcgtg gtggtggatg tgagcgaaga tgatccggat      480

gtgcagatta gctggtttgt gaacaacgtg gaagtgcata ccgcgcagac ccagacccat      540

cgcgaagatt ataacagcac cattcgcgtg gtgagcaccc tgccgattca gcatcaggat      600

tggatgagcg gcaaagaatt taaatgcaaa gtgaacaaca aagatctgcc gagcccgatt      660

gaacgcacca ttagcaaaat taaaggcctg gtgcgcgcgc cgcaggtgta tattctgccg      720

ccgccggcgg aacagctgag ccgcaaagat gtgagcctga cctgcctggt ggtgggcttt      780

aacccgggcg atattagcgt ggaatggacc agcaacggcc ataccgaaga aaactataaa      840

gataccgcgc cggtgctgga tagcgatggc agctatttta tttatagcaa actgaacatg      900

aaaaccagca aatgggaaaa aaccgatagc tttagctgca acgtgcgcca tgaaggcctg      960

aaaaactatt atctgaaaaa aaccattagc cgcagcccgg gcctggatct ggatgatatt     1020

tgcgcggaag cgaaagatgg cgaactggat ggcctgtgga ccaccattac catttttatt     1080

agcctgtttc tgctgagcgt gtgctatagc gcgagcgtga ccctgtttaa agtgaaatgg     1140

atttttagca gcgtggtgga actgaaacag aaaattagcc cggattatcg caacatgatt     1200

ggccagggcg cg                                                         1212


<210>  25
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Glu Val Glu Tyr Arg Ala Glu Val Gly Gln Asn Ala Tyr Leu Pro 
1               5                   10                  15      


Cys Phe Tyr Thr Pro Ala Ala Pro Gly Asn Leu Val Pro Val Cys Trp 
            20                  25                  30          


Gly Lys Gly Ala Cys Pro Val Phe Glu Cys Gly Asn Val Val Leu Arg 
        35                  40                  45              


Thr Asp Glu Arg Asp Val Asn Tyr Trp Thr Ser Arg Tyr Trp Leu Asn 
    50                  55                  60                  


Gly Asp Phe Arg Lys Gly Asp Val Ser Leu Thr Ile Glu Asn Val Thr 
65                  70                  75                  80  


Leu Ala Asp Ser Gly Ile Tyr Cys Cys Arg Ile Gln Ile Pro Gly Ile 
                85                  90                  95      


Met Asn Asp Glu Lys Phe Asn Leu Lys Leu Val Ile Lys Pro Ala Lys 
            100                 105                 110         


Val Thr Pro Ala Pro Thr Arg Gln Arg Asp Phe Thr Ala Ala Phe Pro 
        115                 120                 125             


Arg Met Leu Thr Thr Arg Gly His Gly Pro Ala Glu Thr Gln Thr Leu 
    130                 135                 140                 


Gly Ser Leu Pro Asp Ile Asn Leu Thr Gln Ile Ser Thr Leu Ala Asn 
145                 150                 155                 160 


Glu Leu Arg Asp Ser Arg Leu Ala Asn Asp Leu Arg Asp Ser Gly Ala 
                165                 170                 175     


Thr Ile Arg 
            


<210>  26
<211>  281
<212>  PRT
<213>  Mus musculus

<400>  26

Met Phe Ser Gly Leu Thr Leu Asn Cys Val Leu Leu Leu Leu Gln Leu 
1               5                   10                  15      


Leu Leu Ala Arg Ser Leu Glu Asp Gly Tyr Lys Val Glu Val Gly Lys 
            20                  25                  30          


Asn Ala Tyr Leu Pro Cys Ser Tyr Thr Leu Pro Thr Ser Gly Thr Leu 
        35                  40                  45              


Val Pro Met Cys Trp Gly Lys Gly Phe Cys Pro Trp Ser Gln Cys Thr 
    50                  55                  60                  


Asn Glu Leu Leu Arg Thr Asp Glu Arg Asn Val Thr Tyr Gln Lys Ser 
65                  70                  75                  80  


Ser Arg Tyr Gln Leu Lys Gly Asp Leu Asn Lys Gly Asp Val Ser Leu 
                85                  90                  95      


Ile Ile Lys Asn Val Thr Leu Asp Asp His Gly Thr Tyr Cys Cys Arg 
            100                 105                 110         


Ile Gln Phe Pro Gly Leu Met Asn Asp Lys Lys Leu Glu Leu Lys Leu 
        115                 120                 125             


Asp Ile Lys Ala Ala Lys Val Thr Pro Ala Gln Thr Ala His Gly Asp 
    130                 135                 140                 


Ser Thr Thr Ala Ser Pro Arg Thr Leu Thr Thr Glu Arg Asn Gly Ser 
145                 150                 155                 160 


Glu Thr Gln Thr Leu Val Thr Leu His Asn Asn Asn Gly Thr Lys Ile 
                165                 170                 175     


Ser Thr Trp Ala Asp Glu Ile Lys Asp Ser Gly Glu Thr Ile Arg Thr 
            180                 185                 190         


Ala Ile His Ile Gly Val Gly Val Ser Ala Gly Leu Thr Leu Ala Leu 
        195                 200                 205             


Ile Ile Gly Val Leu Ile Leu Lys Trp Tyr Ser Cys Lys Lys Lys Lys 
    210                 215                 220                 


Leu Ser Ser Leu Ser Leu Ile Thr Leu Ala Asn Leu Pro Pro Gly Gly 
225                 230                 235                 240 


Leu Ala Asn Ala Gly Ala Val Arg Ile Arg Ser Glu Glu Asn Ile Tyr 
                245                 250                 255     


Thr Ile Glu Glu Asn Val Tyr Glu Val Glu Asn Ser Asn Glu Tyr Tyr 
            260                 265                 270         


Cys Tyr Val Asn Ser Gln Gln Pro Ser 
        275                 280     


