                         SEQUENCE LISTING

<110>  McMaster University
 
<120>  CHIMERIC COSTIMULATORY RECEPTORS AND METHODS AND USES THEREOF

<130>  13888-P59885PC00

<140>  PCT/CA2020/051245
<141>  2020-09-16

<150>  US 62/900,911
<151>  2019-09-16

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  210
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  1

Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu Glu 
1               5                   10                  15      


Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His 
            20                  25                  30          


Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr 
        35                  40                  45              


Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly 
    50                  55                  60                  


Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys 
65                  70                  75                  80  


Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg 
                85                  90                  95      


His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu 
            100                 105                 110         


Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys 
        115                 120                 125             


Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn 
    130                 135                 140                 


Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys 
145                 150                 155                 160 


Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn 
                165                 170                 175     


Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys 
            180                 185                 190         


Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly 
        195                 200                 205             


Thr Thr 
    210 


<210>  2
<211>  173
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  2

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn 
                165                 170             


<210>  3
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Lys Arg Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met 
1               5                   10                  15      


Arg Pro Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe 
            20                  25                  30          


Pro Glu Glu Glu Glu Gly Gly Cys Glu Leu 
        35                  40          


<210>  4
<211>  85
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  4

Ser Trp Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu 
1               5                   10                  15      


Ala Pro Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile 
            20                  25                  30          


Ile Leu Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro 
        35                  40                  45              


Pro Gly Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val 
    50                  55                  60                  


Pro Ala Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala 
65                  70                  75                  80  


Gly Pro Glu Gln Gln 
                85  


<210>  5
<211>  21
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  5

Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu 
1               5                   10                  15      


Leu Phe Ile Gly Leu 
            20      


<210>  6
<211>  17
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  6

Leu Gly Trp Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp 
1               5                   10                  15      


Val 
    


<210>  7
<211>  273
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu Glu 
1               5                   10                  15      


Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His 
            20                  25                  30          


Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr 
        35                  40                  45              


Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly 
    50                  55                  60                  


Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys 
65                  70                  75                  80  


Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg 
                85                  90                  95      


His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu 
            100                 105                 110         


Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys 
        115                 120                 125             


Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn 
    130                 135                 140                 


Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys 
145                 150                 155                 160 


Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn 
                165                 170                 175     


Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys 
            180                 185                 190         


Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly 
        195                 200                 205             


Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu 
    210                 215                 220                 


Ser Leu Leu Phe Ile Gly Leu Lys Arg Gly Arg Lys Lys Leu Leu Tyr 
225                 230                 235                 240 


Ile Phe Lys Gln Pro Phe Met Arg Pro Val Gln Thr Thr Gln Glu Glu 
                245                 250                 255     


Asp Gly Cys Ser Cys Arg Phe Pro Glu Glu Glu Glu Gly Gly Cys Glu 
            260                 265                 270         


Leu 
    


<210>  8
<211>  316
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  8

Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu Glu 
1               5                   10                  15      


Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His 
            20                  25                  30          


Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr 
        35                  40                  45              


Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly 
    50                  55                  60                  


Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys 
65                  70                  75                  80  


Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg 
                85                  90                  95      


His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu 
            100                 105                 110         


Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys 
        115                 120                 125             


Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn 
    130                 135                 140                 


Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys 
145                 150                 155                 160 


Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn 
                165                 170                 175     


Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys 
            180                 185                 190         


Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly 
        195                 200                 205             


Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu 
    210                 215                 220                 


Ser Leu Leu Phe Ile Gly Leu Ser Trp Arg Arg Arg Gln Arg Arg Leu 
225                 230                 235                 240 


Arg Gly Ala Ser Ser Ala Glu Ala Pro Asp Gly Asp Lys Asp Ala Pro 
                245                 250                 255     


Glu Pro Leu Asp Lys Val Ile Ile Leu Ser Pro Gly Ile Ser Asp Ala 
            260                 265                 270         


Thr Ala Pro Ala Trp Pro Pro Pro Gly Glu Asp Pro Gly Thr Thr Pro 
        275                 280                 285             


Pro Gly His Ser Val Pro Val Pro Ala Thr Glu Leu Gly Ser Thr Glu 
    290                 295                 300                 


Leu Val Thr Thr Lys Thr Ala Gly Pro Glu Gln Gln 
305                 310                 315     


<210>  9
<211>  232
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  9

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Lys Arg 
            180                 185                 190         


Gly Arg Lys Lys Leu Leu Tyr Ile Phe Lys Gln Pro Phe Met Arg Pro 
        195                 200                 205             


Val Gln Thr Thr Gln Glu Glu Asp Gly Cys Ser Cys Arg Phe Pro Glu 
    210                 215                 220                 


Glu Glu Glu Gly Gly Cys Glu Leu 
225                 230         


<210>  10
<211>  275
<212>  PRT
<213>  Artificial  Sequence

<220>
<223>  Synthetic construct

<400>  10

Met Leu Gly Ile Trp Thr Leu Leu Pro Leu Val Leu Thr Ser Val Ala 
1               5                   10                  15      


Arg Leu Ser Ser Lys Ser Val Asn Ala Gln Val Thr Asp Ile Asn Ser 
            20                  25                  30          


Lys Gly Leu Glu Leu Arg Lys Thr Val Thr Thr Val Glu Thr Gln Asn 
        35                  40                  45              


Leu Glu Gly Leu His His Asp Gly Gln Phe Cys His Lys Pro Cys Pro 
    50                  55                  60                  


Pro Gly Glu Arg Lys Ala Arg Asp Cys Thr Val Asn Gly Asp Glu Pro 
65                  70                  75                  80  


Asp Cys Val Pro Cys Gln Glu Gly Lys Glu Tyr Thr Asp Lys Ala His 
                85                  90                  95      


Phe Ser Ser Lys Cys Arg Arg Cys Arg Leu Cys Asp Glu Gly His Gly 
            100                 105                 110         


Leu Glu Val Glu Ile Asn Cys Thr Arg Thr Gln Asn Thr Lys Cys Arg 
        115                 120                 125             


Cys Lys Pro Asn Phe Phe Cys Asn Ser Thr Val Cys Glu His Cys Asp 
    130                 135                 140                 


Pro Cys Thr Lys Cys Glu His Gly Ile Ile Lys Glu Cys Thr Leu Thr 
145                 150                 155                 160 


Ser Asn Thr Lys Cys Lys Glu Glu Gly Ser Arg Ser Asn Leu Gly Trp 
                165                 170                 175     


Leu Cys Leu Leu Leu Leu Pro Ile Pro Leu Ile Val Trp Val Ser Trp 
            180                 185                 190         


Arg Arg Arg Gln Arg Arg Leu Arg Gly Ala Ser Ser Ala Glu Ala Pro 
        195                 200                 205             


Asp Gly Asp Lys Asp Ala Pro Glu Pro Leu Asp Lys Val Ile Ile Leu 
    210                 215                 220                 


Ser Pro Gly Ile Ser Asp Ala Thr Ala Pro Ala Trp Pro Pro Pro Gly 
225                 230                 235                 240 


Glu Asp Pro Gly Thr Thr Pro Pro Gly His Ser Val Pro Val Pro Ala 
                245                 250                 255     


Thr Glu Leu Gly Ser Thr Glu Leu Val Thr Thr Lys Thr Ala Gly Pro 
            260                 265                 270         


Glu Gln Gln 
        275 


