                         SEQUENCE LISTING

<110>  MEMORIAL SLOAN-KETTERING CANCER CENTER
 
<120>  ANTI-CD371 ANTIBODIES AND USES THEREOF

<130>  072734.1146

<150>  US 62/900,118
<151>  2019-09-13

<150>  US 62/936,913
<151>  2019-11-18

<160>  73    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gln Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Trp Arg Gly Asp Tyr Tyr Ser Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  2

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Thr Ser Glu Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  3
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Gly Ser Gly Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Pro Val Asp Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125 


<210>  4
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  4

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Glu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  5
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Gly Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Glu Leu Gly Ala Thr Thr Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Arg Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Arg Glu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  7
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  7

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Thr 
            20                  25                  30          


Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Thr Glu Val Ser Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  8
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  8

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Arg Ser Trp Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  9
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  9

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Asp Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Asp Tyr Asp Ser Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120         


<210>  10
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  10

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Gly Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Asp Tyr Ala Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys 
    


<210>  11
<211>  127
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  11

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asp Gly Glu Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Asp Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125         


<210>  12
<211>  114
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  12

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Thr Ser Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly 
        


<210>  13
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  13

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser 
            


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  14

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  15
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Glu Glu Val Thr Tyr Ala Asp Leu Gln Phe Gln Asn Ser Ser 
1               5                   10                  15      


Glu Met Glu Lys Ile Pro Glu Ile Gly Lys Phe Gly Glu Lys Ala Pro 
            20                  25                  30          


Pro Ala Pro Ser His Val Trp Arg Pro Ala Ala Leu Phe Leu Thr Leu 
        35                  40                  45              


Leu Cys Leu Leu Leu Leu Ile Gly Leu Gly Val Leu Ala Ser Met Phe 
    50                  55                  60                  


His Val Thr Leu Lys Ile Glu Met Lys Lys Met Asn Lys Leu Gln Asn 
65                  70                  75                  80  


Ile Ser Glu Glu Leu Gln Arg Asn Ile Ser Leu Gln Leu Met Ser Asn 
                85                  90                  95      


Met Asn Ile Ser Asn Lys Ile Arg Asn Leu Ser Thr Thr Leu Gln Thr 
            100                 105                 110         


Ile Ala Thr Lys Leu Cys Arg Glu Leu Tyr Ser Lys Glu Gln Glu His 
        115                 120                 125             


Lys Cys Lys Pro Cys Pro Arg Arg Trp Ile Trp His Lys Asp Ser Cys 
    130                 135                 140                 


Tyr Phe Leu Ser Asp Asp Val Gln Thr Trp Gln Glu Ser Lys Met Ala 
145                 150                 155                 160 


Cys Ala Ala Gln Asn Ala Ser Leu Leu Lys Ile Asn Asn Lys Asn Ala 
                165                 170                 175     


Leu Glu Phe Ile Lys Ser Gln Ser Arg Ser Tyr Asp Tyr Trp Leu Gly 
            180                 185                 190         


Leu Ser Pro Glu Glu Asp Ser Thr Arg Gly Met Arg Val Asp Asn Ile 
        195                 200                 205             


Ile Asn Ser Ser Ala Trp Val Ile Arg Asn Ala Pro Asp Leu Asn Asn 
    210                 215                 220                 


Met Tyr Cys Gly Tyr Ile Asn Arg Leu Tyr Val Gln Tyr Tyr His Cys 
225                 230                 235                 240 


Thr Tyr Lys Lys Arg Met Ile Cys Glu Lys Met Ala Asn Pro Val Gln 
                245                 250                 255     


Leu Gly Ser Thr Tyr Phe Arg Glu Ala 
            260                 265 


<210>  16
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  16

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Thr Ser Glu Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Asp Tyr Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Gln Gly Gly Gly Gly Ser Thr Tyr Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Met Trp Arg Gly Asp Tyr Tyr Ser Gly 
225                 230                 235                 240 


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
                245                 250                 


<210>  17
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  17

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser 
            20                  25                  30          


Tyr Asn Asn Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Glu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Asp Gly Ser Gly Gly Gly Thr Asn Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Pro 
225                 230                 235                 240 


Val Asp Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser 
                245                 250                 255     


Ser 
    


<210>  18
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  18

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Arg Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Arg Glu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Thr Asp Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Asp Ile Asp Gly Ser Gly Gly Ser Thr Asp Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Leu Glu Leu Gly Ala Thr Thr Val Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  19
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  19

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Ser 
            20                  25                  30          


Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Arg Ser Trp Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Thr Gln 
145                 150                 155                 160 


Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Glu Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Asp Thr Glu Val Ser Gly Asp Ala Phe Asp Ile Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Met Val Thr Val Ser Ser 
                245         


<210>  20
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  20

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser 
            20                  25                  30          


Gly Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Asp Tyr Ala Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Thr Ser Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Asp Ser Thr Ser Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Ala Gly Gly Asp Tyr Asp Ser Gly Ala 
225                 230                 235                 240 


Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
                245                 250                 


<210>  21
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Gly Thr Ser Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 
    130                 135                 140                 


Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 
145                 150                 155                 160 


Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 
                165                 170                 175     


Leu Glu Trp Val Ser Glu Ile Asp Gly Glu Gly Gly Tyr Thr Asn Tyr 
            180                 185                 190         


Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 
        195                 200                 205             


Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Glu Gly Val Asp Tyr Asp Ile Leu Thr Gly 
225                 230                 235                 240 


Tyr Tyr Pro Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr 
                245                 250                 255     


Val Ser Ser 
            


<210>  22
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  22
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgtgccacc       60

atcaactgca agtccagcca gagtgtttta gacagctata acaatgagaa caatttagct      120

tggtatcagc agaaaccagg acagcctcct aagctgctca tttactgggc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata taccagcgaa      300

cctatcacgt tcggccaagg taccaaggtg gaaatcaaag gtggtggtgg ttcaggtggt      360

ggtggttctg gcggcggctc cggtggtggt ggatccgagg tgcagctgtt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg cgactctcct gtgcagcctc tggattcacc      480

tttagcgact atcagatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg      540

tcaggcattc agggtggcgg tggtagcaca tattacgcag actccgtgaa gggccggttc      600

accatctccc gtgacaattc caagaacacg ctgtatctgc aaatgaacag cctgcgtgcc      660

gaggacacgg ctgtgtatta ctgtgcgaga gagatgtggc gtggggacta ctactccggt      720

atggacgtct ggggccaggg gaccacggtc accgtctcct ca                         762


<210>  23
<211>  771
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  23
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgtgccacc       60

atcaactgca agtccagcca gagtgtttta agcagctata acaatgagaa caatttagct      120

tggtatcagc agaaaccagg acagcctcct aagctgctca tttacgccgc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatagcgaa      300

ccttatacgt tcggccaagg taccaaggtg gaaatcaaag gtggtggtgg ttcaggtggt      360

ggtggttctg gcggcggctc cggtggtggt ggatccgagg tgcagctgtt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg cgactctcct gtgcagcctc tggattcacc      480

tttaccagct atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg      540

tcaggcattg acggtagcgg tggtggcaca aattacgcag actccgtgaa gggccggttc      600

accatctccc gtgacaattc caagaacacg ctgtatctgc aaatgaacag cctgcgtgcc      660

gaggacacgg ctgtgtatta ctgtgcgaga gcgtattacg atattttgac tggttacccc      720

gtggacggta tggacgtctg gggccaaggg accacggtca ccgtctcctc a               771


<210>  24
<211>  747
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  24
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgtgccacc       60

atcaactgca agtccagcca gagtgtttta cgcagcagca acaataaaaa caatttagct      120

tggtatcagc agaaaccagg acagcctcct aagctgctca tttacgccgc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata ttatcgcgaa      300

cctctgacgt tcggccaagg taccaaggtg gaaatcaaag gtggtggtgg ttcaggtggt      360

ggtggttctg gcggcggctc cggtggtggt ggatccgagg tgcagctgtt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg cgactctcct gtgcagcctc tggattcacc      480

tttaccgact atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg      540

tcagacattg acggtagcgg tggtagcaca gactacgcag actccgtgaa gggccggttc      600

accatctccc gtgacaattc caagaacacg ctgtatctgc aaatgaacag cctgcgtgcc      660

gaggacacgg ctgtgtatta ctgtgcgcta gagctgggag ctactaccgt ctactggggc      720

cagggaaccc tggtcaccgt ctcctca                                          747


<210>  25
<211>  741
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  25
gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga acgtgccacc       60

ctctcctgcc gtgccagtca gagtgttgac agcagcaatt tagcctggta tcagcagaaa      120

cctggccagg ctccccgact cctcatctat ggcgcatcta gccgtgccac tggtatccca      180

gaccgtttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag      240

cctgaagatt ttgcagtgta ttactgtcag cagtatcgca gctggcctat cacgttcggc      300

caaggtacca aggtggaaat caaaggtggt ggtggttcag gtggtggtgg ttctggcggc      360

ggctccggtg gtggtggatc cgaggtgcag ctgttggagt ctgggggagg cttggtacag      420

cctggggggt ccctgcgact ctcctgtgca gcctctggat tcacctttac cagcacccag      480

atgagctggg tccgccaggc tccagggaag gggctggagt gggtgtcaga gattagcggt      540

tatggtggta gcacatacta cgcagactcc gtgaagggcc ggttcaccat ctcccgtgac      600

aattccaaga acacgctgta tctgcaaatg aacagcctgc gtgccgagga cacggctgtg      660

tattactgtg caaaagacac ggaggtttcg ggagatgctt ttgatatctg gggccaaggg      720

acaatggtca ccgtctcttc a                                                741


<210>  26
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  26
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgtgccacc       60

atcaactgca agtccagcca gagtgtttta tatagcggca acaataaaaa ctatttagct      120

tggtatcagc agaaaccagg acagcctcct aagctgctca tttacggcgc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaata tgactatgcc      300

ccttttacgt tcggccaagg taccaaggtg gaaatcaaag gtggtggtgg ttcaggtggt      360

ggtggttctg gcggcggctc cggtggtggt ggatccgagg tgcagctgtt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg cgactctcct gtgcagcctc tggattcacc      480

tttaccagct attatatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg      540

tcaggcatta gcggtagcgg tgacagcaca agctacgcag actccgtgaa gggccggttc      600

accatctccc gtgacaattc caagaacacg ctgtatctgc aaatgaacag cctgcgtgcc      660

gaggacacgg ctgtgtatta ctgtgcgaga gaggcaggtg gtgactacga tagtggtgct      720

tttgatatct ggggccaagg gacaatggtc accgtctctt ca                         762


<210>  27
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic polynucleotide

<400>  27
gacatcgtga tgacccagtc tccagactcc ctggctgtgt ctctgggcga gcgtgccacc       60

atcaactgca agtccagcca gagtgtttta gacagcagca acaataaaaa ctatttagct      120

tggtatcagc agaaaccagg acagcctcct aagctgctca tttacgacgc atctacccgg      180

gaatccgggg tccctgaccg attcagtggc agcgggtctg ggacagattt cactctcacc      240

atcagcagcc tgcaggctga agatgtggca gtttattact gtcagcaagg caccagcagc      300

cctctgacgt tcggccaagg taccaaggtg gaaatcaaag gtggtggtgg ttcaggtggt      360

ggtggttctg gcggcggctc cggtggtggt ggatccgagg tgcagctgtt ggagtctggg      420

ggaggcttgg tacagcctgg ggggtccctg cgactctcct gtgcagcctc tggattcacc      480

tttagcagct atgccatgag ctgggtccgc caggctccag ggaaggggct ggagtgggtg      540

tcagagattg acggtgaggg tggttataca aattacgcag actccgtgaa gggccggttc      600

accatctccc gtgacaattc caagaacacg ctgtatctgc aaatgaacag cctgcgtgcc      660

gaggacacgg ccgtgtatta ctgtgcgaga gaaggggtag attacgatat tttgactggt      720

tattatcctt acggtatgga cgtctggggc caagggacca cggtcaccgt ctcctca         777


<210>  28
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  28

Gly Phe Thr Phe Ser Asp Tyr Gln 
1               5               


<210>  29
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  29

Ile Gln Gly Gly Gly Gly Ser Thr 
1               5               


<210>  30
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  30

Ala Arg Glu Met Trp Arg Gly Asp Tyr Tyr Ser Gly Met Asp Val 
1               5                   10                  15  


<210>  31
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  31

Gln Ser Val Leu Asp Ser Tyr Asn Asn Glu Asn Asn 
1               5                   10          


<210>  32
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  32

Trp Ala Ser 
1           


<210>  33
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  33

Gln Gln Tyr Thr Ser Glu Pro Ile Thr 
1               5                   


<210>  34
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  34

Gly Phe Thr Phe Thr Ser Tyr Ala 
1               5               


<210>  35
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  35

Ile Asp Gly Ser Gly Gly Gly Thr 
1               5               


<210>  36
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  36

Ala Arg Ala Tyr Tyr Asp Ile Leu 
1               5               


<210>  37
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  37

Gln Ser Val Leu Ser Ser Tyr Asn Asn Glu Asn Asn 
1               5                   10          


<210>  38
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  38

Ala Ala Ser 
1           


<210>  39
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Gln Gln Tyr Tyr Ser Glu Pro Tyr Thr 
1               5                   


<210>  40
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  40

Gly Phe Thr Phe Thr Asp Tyr Ala 
1               5               


<210>  41
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  41

Ile Asp Gly Ser Gly Gly Ser Thr 
1               5               


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  42

Ala Leu Glu Leu Gly Ala Thr Thr Val Tyr 
1               5                   10  


<210>  43
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  43

Gln Ser Val Leu Arg Ser Ser Asn Asn Lys Asn Asn 
1               5                   10          


<210>  44
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  44

Ala Ala Ser 
1           


<210>  45
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  45

Gln Gln Tyr Tyr Arg Glu Pro Leu Thr 
1               5                   


<210>  46
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  46

Gly Phe Thr Phe Thr Ser Thr Gln 
1               5               


<210>  47
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  47

Ile Ser Gly Tyr Gly Gly Ser Thr 
1               5               


<210>  48
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  48

Ala Lys Asp Thr Glu Val Ser Gly Asp Ala Phe Asp Ile 
1               5                   10              


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  49

Gln Ser Val Asp Ser Ser Asn 
1               5           


<210>  50
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  50

Gly Ala Ser 
1           


<210>  51
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  51

Gln Gln Tyr Arg Ser Trp Pro Ile Thr 
1               5                   


<210>  52
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  52

Gly Phe Thr Phe Thr Ser Tyr Tyr 
1               5               


<210>  53
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  53

Ile Ser Gly Ser Gly Asp Ser Thr 
1               5               


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  54

Ala Arg Glu Ala Gly Gly Asp Tyr Asp Ser Gly Ala Phe Asp Ile 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  55

Gln Ser Val Leu Tyr Ser Gly Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  56
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  56

Gly Ala Ser 
1           


<210>  57
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  57

Gln Gln Tyr Asp Tyr Ala Pro Phe Thr 
1               5                   


<210>  58
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  58

Gly Phe Thr Phe Ser Ser Tyr Ala 
1               5               


<210>  59
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  59

Ile Asp Gly Glu Gly Gly Tyr Thr 
1               5               


<210>  60
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  60

Ala Arg Glu Gly Val Asp Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Tyr 
1               5                   10                  15      


Gly Met Asp Val 
            20  


<210>  61
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  61

Gln Ser Val Leu Asp Ser Ser Asn Asn Lys Asn Tyr 
1               5                   10          


<210>  62
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  62

Asp Ala Ser 
1           


<210>  63
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  63

Gln Gln Gly Thr Ser Ser Pro Leu Thr 
1               5                   


<210>  64
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  64

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  


<210>  65
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  


<210>  66
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  66

Gly Gly Gly Gly Ser 
1               5   


<210>  67
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  68
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  68

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Gln Gly Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Met Trp Arg Gly Asp Tyr Tyr Ser Gly Met Asp Val Trp 
            100                 105                 110         


Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Asp Ser Tyr Asn Asn 
                165                 170                 175     


Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Thr Ser 
225                 230                 235                 240 


Glu Pro Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250                 


<210>  69
<211>  257
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  69

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Asp Gly Ser Gly Gly Gly Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Tyr Tyr Asp Ile Leu Thr Gly Tyr Pro Val Asp Gly Met 
            100                 105                 110         


Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
145                 150                 155                 160 


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Ser Ser 
                165                 170                 175     


Tyr Asn Asn Glu Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
            180                 185                 190         


Pro Pro Lys Leu Leu Ile Tyr Ala Ala Ser Thr Arg Glu Ser Gly Val 
        195                 200                 205             


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
    210                 215                 220                 


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
225                 230                 235                 240 


Tyr Tyr Ser Glu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile 
                245                 250                 255     


Lys 
    


<210>  70
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  70

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asp Ile Asp Gly Ser Gly Gly Ser Thr Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Leu Glu Leu Gly Ala Thr Thr Val Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro 
    130                 135                 140                 


Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys 
145                 150                 155                 160 


Ser Ser Gln Ser Val Leu Arg Ser Ser Asn Asn Lys Asn Asn Leu Ala 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr Ala 
            180                 185                 190         


Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly 
        195                 200                 205             


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp 
    210                 215                 220                 


Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Arg Glu Pro Leu Thr Phe 
225                 230                 235                 240 


Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 


<210>  71
<211>  247
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  71

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Thr 
            20                  25                  30          


Gln Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Ser Gly Tyr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Asp Thr Glu Val Ser Gly Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Ser Val Asp Ser Ser Asn Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Gln Gln Tyr Arg Ser Trp Pro Ile Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  72
<211>  254
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  72

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Tyr 
            20                  25                  30          


Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Gly Ser Gly Asp Ser Thr Ser Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Ala Gly Gly Asp Tyr Asp Ser Gly Ala Phe Asp Ile Trp 
            100                 105                 110         


Gly Gln Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val 
    130                 135                 140                 


Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala 
145                 150                 155                 160 


Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu Tyr Ser Gly Asn Asn 
                165                 170                 175     


Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys 
            180                 185                 190         


Leu Leu Ile Tyr Gly Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg 
        195                 200                 205             


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
    210                 215                 220                 


Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Tyr 
225                 230                 235                 240 


Ala Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
                245                 250                 


<210>  73
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  73

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Glu Ile Asp Gly Glu Gly Gly Tyr Thr Asn Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Gly Val Asp Tyr Asp Ile Leu Thr Gly Tyr Tyr Pro Tyr 
            100                 105                 110         


Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly 
    130                 135                 140                 


Gly Ser Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser 
145                 150                 155                 160 


Leu Gly Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Val Leu 
                165                 170                 175     


Asp Ser Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
            180                 185                 190         


Gly Gln Pro Pro Lys Leu Leu Ile Tyr Asp Ala Ser Thr Arg Glu Ser 
        195                 200                 205             


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
    210                 215                 220                 


Leu Thr Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys 
225                 230                 235                 240 


Gln Gln Gly Thr Ser Ser Pro Leu Thr Phe Gly Gln Gly Thr Lys Val 
                245                 250                 255     


Glu Ile Lys 
            


