                         SEQUENCE LISTING

<110>  DANA-FARBER CANCER INSTITUTE, INC.
 
<120>  METHODS FOR TREATING CANCER USING SERIAL ADMINISTRATION OF E3 
       UBIQUITIN LIGASE DEGRADERS

<130>  DFS-28325

<140>  PCT/US2020/050339
<141>  2020-09-11

<150>  US 62/899,656
<151>  2019-09-12

<160>  67    

<170>  PatentIn version 3.5

<210>  1
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  1
aatggactat catatgctta ccgtaacttg aaagtatttc g                           41


<210>  2
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  2
ctttagtttg tatgtctgtt gctattatgt ctactattct ttcc                        44


<210>  3
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  3
caagcagaag acggcatacg agatcctctc tggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  4
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  4
caagcagaag acggcatacg agatctagta cggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  5
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  5
caagcagaag acggcatacg agatttctgc ctgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  6
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  6
caagcagaag acggcatacg agatgctcag gagtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  7
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  7
caagcagaag acggcatacg agataggagt ccgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  8
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  8
caagcagaag acggcatacg agatcatgcc tagtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  9
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  9
caagcagaag acggcatacg agatgtagag aggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  10
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  10
caagcagaag acggcatacg agataacaat gggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  11
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  11
caagcagaag acggcatacg agatagcgta gcgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  12
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  12
caagcagaag acggcatacg agatcagcct cggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  13
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  13
caagcagaag acggcatacg agatagtagc gtgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  14
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  14
caagcagaag acggcatacg agatcagtga gtgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  15
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  15
caagcagaag acggcatacg agatcgtact cagtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  16
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  16
caagcagaag acggcatacg agatctacgc aggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  17
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  17
caagcagaag acggcatacg agatggagac tagtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  18
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  18
caagcagaag acggcatacg agataggtaa gggtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  19
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  19
caagcagaag acggcatacg agataacgca ttgtgactgg agttcagacg tgtgctcttc       60

cgatcttcta ctattctttc ccctgcact                                         89


<210>  20
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  20
caagcagaag acggcatacg agatacaggt atgtgactgg agttcagacg tgtgctcttc       60


<210>  21
<211>  82
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  21
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatcttc       60

ttgtggaaag gacgaaacac cg                                                82


<210>  22
<211>  83
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  22
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctat       60

cttgtggaaa ggacgaaaca ccg                                               83


<210>  23
<211>  84
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  23
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctta       60

tcttgtggaa aggacgaaac accg                                              84


<210>  24
<211>  85
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  24
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctgt       60

atcttgtgga aaggacgaaa caccg                                             85


<210>  25
<211>  86
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  25
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctcg       60

tatcttgtgg aaaggacgaa acaccg                                            86


<210>  26
<211>  87
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  26
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctac       60

gtatcttgtg gaaaggacga aacaccg                                           87


<210>  27
<211>  88
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  27
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctga       60

cgtatcttgt ggaaaggacg aaacaccg                                          88


<210>  28
<211>  89
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  28
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctag       60

acgtatcttg tggaaaggac gaaacaccg                                         89


<210>  29
<211>  90
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  29
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctca       60

gacgtatctt gtggaaagga cgaaacaccg                                        90


<210>  30
<211>  91
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  30
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatcttc       60

agacgtatct tgtggaaagg acgaaacacc g                                      91


<210>  31
<211>  92
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic primer"

<400>  31
aatgatacgg cgaccaccga gatctacact ctttccctac acgacgctct tccgatctgt       60

cagacgtatc ttgtggaaag gacgaaacac cg                                     92


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  32
tggccgtgac atccgaaaga                                                   20


<210>  33
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  33
tcttgatgcc aagctcacga                                                   20


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  34
tctttcagca acacggagta                                                   20


<210>  35
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  35
gcatcttacc atcgtgagct                                                   20


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  36
ttgttgaacc tgtttgccta                                                   20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  37
gtggttctct ttgtactggt                                                   20


<210>  38
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  38
gtggtggtaa aatgcacttg                                                   20


<210>  39
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  39
tagtaactcc gagccaaatg                                                   20


<210>  40
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  40
ccagttacat cagtcgtgcc                                                   20


<210>  41
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  41
gtggtttaag acaaacacaa                                                   20


<210>  42
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  42
cattgtcgat atgtgcgtgg                                                   20


<210>  43
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  43
ggatagccat ctgaattgag                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  44
ctaccaacct gcgatcacca                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  45
tcgtgtcttg gacttcaatg                                                   20


<210>  46
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  46
agtatacgct tgagagacca                                                   20


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  47
agaagctgac catacactgg                                                   20


<210>  48
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  48
caaccatcaa cgctcaccag                                                   20


<210>  49
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  49
gcaggcaaat tctgaacttg                                                   20


<210>  50
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  50
atcagcccat ttctgcgcac                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  51
aggggcaggg ctatcttatg                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  52
gcacatcgtt atataccaga                                                   20


<210>  53
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  53
cagggttgcg cagaggactc                                                   20


<210>  54
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  54
gatggccttt gaccgatacg                                                   20


<210>  55
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  55
gatggcattt gacctctctg                                                   20


<210>  56
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  56
gagaaggaga tggtttcctg                                                   20


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  57
gatgagatag cactcactgg                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  58
gaaaccagca gcccagcatg                                                   20


<210>  59
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  59
ggaggcttct tagatttggg                                                   20


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  60
gagcagcggc tgtacaaggt                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  61
gcttcaccag tcaaacagca                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  62
agatatctat gctttatgtg                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  63
cagcatgtga gtaaagtctg                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  64
ggaatcctac tcagaatgtg                                                   20


<210>  65
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  65
accaatgttc atataaatgg                                                   20


<210>  66
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  66
ctgactgtgt tcttagctca                                                   20


<210>  67
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  /note="Description of Artificial Sequence: Synthetic sgRNA 
       sequence"

<400>  67
tgaagaggta atgtctgtcc                                                   20