                         SEQUENCE LISTING

<110>  The Regents of the University of California
 
<120>  SYSTEMS AND METHODS FOR THE PREPARATION OF PEPTIDE-MHC-I 
       COMPLEXES WITH NATIVE GLYCAN MODIFICATIONS

<130>  116550-5011-WO

<140>  PCT/US20/50276
<141>  2020-09-11

<150>  62/900,260
<151>  2019-09-13

<150>  62/957,040
<151>  2020-01-03

<150>  63/011,221
<151>  2020-04-16

<150>  63/047,812
<151>  2020-07-02

<150>  63/076,601
<151>  2020-09-10

<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  1

Leu Leu Phe Gly Val Pro Val Tyr Val 
1               5                   


<210>  2
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  2

Ser Leu Leu Met Trp Ile Thr Gln Ala 
1               5                   


<210>  3
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  3

Gly Leu Leu Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  4

Glu Thr Ala Gly Val Pro Ala Asp Val 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  5

Glu Thr Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  6
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  6

Gly Leu Leu Gly Val Pro Leu Tyr Val 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  7

Tyr Pro Asn Val Asn Ile His Asn Phe 
1               5                   


<210>  8
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  8

Arg Gly Pro Gly Arg Ala Phe Val Phe Ile 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Glu Ala Ala Gly Ile Gly Ile Leu Thr Val 
1               5                   10  


<210>  10
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Val Tyr Gly Phe Val Arg Ala Cys Leu 
1               5                   


<210>  11
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Arg Tyr Pro Leu Thr Phe Gly Trp Cys Phe 
1               5                   10  


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Ala Leu Asn Thr Leu Val Lys Gln Leu 
1               5                   


<210>  13
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Val Leu Asn Asp Ile Leu Ser Arg Leu 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Arg Leu Asn Glu Val Ala Lys Asn Leu 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Asn Leu Asn Glu Ser Leu Ile Asp Leu 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  16

Phe Ile Ala Gly Leu Ile Ala Ile Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  17

Gly Leu Met Trp Leu Ser Tyr Phe Ile 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  18

Leu Leu Leu Asp Arg Leu Asn Gln Leu 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  19

Gly Met Ser Arg Ile Gly Met Glu Val 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  20

Trp Leu Met Trp Leu Ile Ile Asn Leu 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  21

Ile Leu Leu Leu Asp Gln Ala Leu Val 
1               5                   


<210>  22
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  22

Ser Leu Pro Gly Val Phe Cys Gly Val 
1               5                   


<210>  23
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  23

Thr Leu Ala Cys Phe Val Leu Ala Ala Val 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  24

Lys Leu Pro Asp Asp Phe Thr Gly Cys Val 
1               5                   10  


<210>  25
<211>  99
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-2 microglobulin

<400>  25

Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg His Pro Ala Glu 
1               5                   10                  15      


Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser Gly Phe His Pro 
            20                  25                  30          


Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu Arg Ile Glu Lys 
        35                  40                  45              


Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp Ser Phe Tyr Leu 
    50                  55                  60                  


Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp Glu Tyr Ala Cys 
65                  70                  75                  80  


Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile Val Lys Trp Asp 
                85                  90                  95      


Arg Asp Met 
            


<210>  26
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*02:01

<400>  26

Gly Ser His Ser Met Arg Tyr Phe Phe Thr Ser Val Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Gly Glu Thr 
    50                  55                  60                  


Arg Lys Val Lys Ala His Ser Gln Thr His Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Val Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Ser Asp Trp Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Leu Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Arg Trp Glu Pro Ser 
        275         


<210>  27
<211>  278
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*24:02

<400>  27

Gly Ser Ser His Ser Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro 
1               5                   10                  15      


Gly Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr 
            20                  25                  30          


Gln Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro 
        35                  40                  45              


Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu 
    50                  55                  60                  


Thr Gly Lys Val Lys Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg 
65                  70                  75                  80  


Ile Ala Leu Arg Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu 
                85                  90                  95      


Gln Met Met Phe Gly Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg 
            100                 105                 110         


Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys 
        115                 120                 125             


Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr 
    130                 135                 140                 


Lys Arg Lys Trp Glu Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr 
145                 150                 155                 160 


Leu Glu Gly Thr Cys Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly 
                165                 170                 175     


Lys Glu Thr Leu Gln Arg Thr Asp Pro Pro Lys Thr His Met Thr His 
            180                 185                 190         


His Pro Ile Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly 
        195                 200                 205             


Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp 
    210                 215                 220                 


Gln Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly 
225                 230                 235                 240 


Thr Phe Gln Lys Trp Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln 
                245                 250                 255     


Arg Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr 
            260                 265                 270         


Leu Arg Trp Glu Pro Ser 
        275             


<210>  28
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HLA-A*68:02

<400>  28

Gly Ser His Ser Met Arg Tyr Phe Tyr Thr Ser Met Ser Arg Pro Gly 
1               5                   10                  15      


Arg Gly Glu Pro Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln 
            20                  25                  30          


Phe Val Arg Phe Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg 
        35                  40                  45              


Ala Pro Trp Ile Glu Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr 
    50                  55                  60                  


Arg Asn Val Lys Ala Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr 
65                  70                  75                  80  


Leu Arg Gly Tyr Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln 
                85                  90                  95      


Arg Met Tyr Gly Cys Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly 
            100                 105                 110         


Tyr His Gln Tyr Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu 
        115                 120                 125             


Asp Leu Arg Ser Trp Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys 
    130                 135                 140                 


His Lys Trp Glu Ala Ala His Val Ala Glu Gln Trp Arg Ala Tyr Leu 
145                 150                 155                 160 


Glu Gly Thr Cys Val Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys 
                165                 170                 175     


Glu Thr Leu Gln Arg Thr Asp Ala Pro Lys Thr His Met Thr His His 
            180                 185                 190         


Ala Val Ser Asp His Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe 
        195                 200                 205             


Tyr Pro Ala Glu Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln 
    210                 215                 220                 


Thr Gln Asp Thr Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr 
225                 230                 235                 240 


Phe Gln Lys Trp Val Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg 
                245                 250                 255     


Tyr Thr Cys His Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu 
            260                 265                 270         


Lys Trp Glu Pro Ser 
        275         


<210>  29
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  29

Glu Val Asp Gly Gly Gly Gly Gly Leu Thr Asp Thr Leu Gln Ala Glu 
1               5                   10                  15      


Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala 
            20                  25                  30          


Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His 
        35                  40                  45              


<210>  30
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  30

Glu Asn Leu Tyr Phe Gln Ser 
1               5           


<210>  31
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  31

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


<210>  32
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  32

Ser Gln Ser Gly 
1               


<210>  33
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  33

Gly Gly Gly Gly Ser 
1               5   


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  34

Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu 
1               5                   10                  15  


<210>  35
<211>  496
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  35

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met Gly Gly Gly Ser Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Ser Gly Ser His Ser Met Arg Tyr Phe Phe 
    130                 135                 140                 


Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro Arg Phe Ile Ala Val 
145                 150                 155                 160 


Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp Ser Asp Ala Ala 
                165                 170                 175     


Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu Gln Glu Gly Pro 
            180                 185                 190         


Glu Tyr Trp Asp Gly Glu Thr Arg Lys Val Lys Ala His Ser Gln Thr 
        195                 200                 205             


His Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr Asn Gln Ser Glu 
    210                 215                 220                 


Ala Gly Ser His Thr Val Gln Arg Met Tyr Gly Cys Asp Val Gly Ser 
225                 230                 235                 240 


Asp Trp Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala Tyr Asp Gly Lys 
                245                 250                 255     


Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp Thr Ala Ala Asp 
            260                 265                 270         


Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala Ala His Val Ala 
        275                 280                 285             


Glu Gln Leu Arg Ala Tyr Leu Glu Gly Thr Cys Val Glu Trp Leu Arg 
    290                 295                 300                 


Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg Thr Asp Ala Pro 
305                 310                 315                 320 


Lys Thr His Met Thr His His Ala Val Ser Asp His Glu Ala Thr Leu 
                325                 330                 335     


Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile Thr Leu Thr Trp 
            340                 345                 350         


Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu Leu Val Glu Thr 
        355                 360                 365             


Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Ala Ala Val Val Val 
    370                 375                 380                 


Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val Gln His Glu Gly 
385                 390                 395                 400 


Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro Ser Ser Gln Ser Gly 
                405                 410                 415     


Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Gly 
            420                 425                 430         


Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Ser Gly Gly Gly Gly Ser 
        435                 440                 445             


Glu Val Asp Gly Gly Gly Gly Gly Leu Thr Asp Thr Leu Gln Ala Glu 
    450                 455                 460                 


Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln Thr Glu Ile Ala 
465                 470                 475                 480 


Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile Leu Ala Ala His 
                485                 490                 495     


<210>  36
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  36

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Ser His Ser 
    130                 135                 140                 


Met Arg Tyr Phe Ser Thr Ser Val Ser Arg Pro Gly Arg Gly Glu Pro 
145                 150                 155                 160 


Arg Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe 
                165                 170                 175     


Asp Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile 
            180                 185                 190         


Glu Gln Glu Gly Pro Glu Tyr Trp Asp Glu Glu Thr Gly Lys Val Lys 
        195                 200                 205             


Ala His Ser Gln Thr Asp Arg Glu Asn Leu Arg Ile Ala Leu Arg Tyr 
    210                 215                 220                 


Tyr Asn Gln Ser Glu Ala Gly Ser His Thr Leu Gln Met Met Phe Gly 
225                 230                 235                 240 


Cys Asp Val Gly Ser Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr 
                245                 250                 255     


Ala Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser 
            260                 265                 270         


Trp Thr Ala Ala Asp Met Ala Ala Gln Ile Thr Lys Arg Lys Trp Glu 
        275                 280                 285             


Ala Ala His Val Ala Glu Gln Gln Arg Ala Tyr Leu Glu Gly Thr Cys 
    290                 295                 300                 


Val Asp Gly Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln 
305                 310                 315                 320 


Arg Thr Asp Pro Pro Lys Thr His Met Thr His His Pro Ile Ser Asp 
                325                 330                 335     


His Glu Ala Thr Leu Arg Cys Trp Ala Leu Gly Phe Tyr Pro Ala Glu 
            340                 345                 350         


Ile Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr 
        355                 360                 365             


Glu Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp 
    370                 375                 380                 


Ala Ala Val Val Val Pro Ser Gly Glu Glu Gln Arg Tyr Thr Cys His 
385                 390                 395                 400 


Val Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Arg Trp Glu Pro 
                405                 410                 415     


Ser Ser Gln Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile 
            420                 425                 430         


Glu Trp His Glu Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Ser 
        435                 440                 445             


Gly Gly Gly Gly Ser Glu Val Asp Gly Gly Gly Gly Gly Leu Thr Asp 
    450                 455                 460                 


Thr Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu 
465                 470                 475                 480 


Gln Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe 
                485                 490                 495     


Ile Leu Ala Ala His 
            500     


<210>  37
<211>  500
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  37

Met Ser Arg Ser Val Ala Leu Ala Val Leu Ala Leu Leu Ser Leu Ser 
1               5                   10                  15      


Gly Leu Glu Ala Ile Gln Arg Thr Pro Lys Ile Gln Val Tyr Ser Arg 
            20                  25                  30          


His Pro Ala Glu Asn Gly Lys Ser Asn Phe Leu Asn Cys Tyr Val Ser 
        35                  40                  45              


Gly Phe His Pro Ser Asp Ile Glu Val Asp Leu Leu Lys Asn Gly Glu 
    50                  55                  60                  


Arg Ile Glu Lys Val Glu His Ser Asp Leu Ser Phe Ser Lys Asp Trp 
65                  70                  75                  80  


Ser Phe Tyr Leu Leu Tyr Tyr Thr Glu Phe Thr Pro Thr Glu Lys Asp 
                85                  90                  95      


Glu Tyr Ala Cys Arg Val Asn His Val Thr Leu Ser Gln Pro Lys Ile 
            100                 105                 110         


Val Lys Trp Asp Arg Asp Met Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser His Ser Met 
    130                 135                 140                 


Arg Tyr Phe Tyr Thr Ser Met Ser Arg Pro Gly Arg Gly Glu Pro Arg 
145                 150                 155                 160 


Phe Ile Ala Val Gly Tyr Val Asp Asp Thr Gln Phe Val Arg Phe Asp 
                165                 170                 175     


Ser Asp Ala Ala Ser Gln Arg Met Glu Pro Arg Ala Pro Trp Ile Glu 
            180                 185                 190         


Gln Glu Gly Pro Glu Tyr Trp Asp Arg Asn Thr Arg Asn Val Lys Ala 
        195                 200                 205             


Gln Ser Gln Thr Asp Arg Val Asp Leu Gly Thr Leu Arg Gly Tyr Tyr 
    210                 215                 220                 


Asn Gln Ser Glu Ala Gly Ser His Thr Ile Gln Arg Met Tyr Gly Cys 
225                 230                 235                 240 


Asp Val Gly Pro Asp Gly Arg Phe Leu Arg Gly Tyr His Gln Tyr Ala 
                245                 250                 255     


Tyr Asp Gly Lys Asp Tyr Ile Ala Leu Lys Glu Asp Leu Arg Ser Trp 
            260                 265                 270         


Thr Ala Ala Asp Met Ala Ala Gln Thr Thr Lys His Lys Trp Glu Ala 
        275                 280                 285             


Ala His Val Ala Glu Gln Trp Arg Ala Tyr Leu Glu Gly Thr Cys Val 
    290                 295                 300                 


Glu Trp Leu Arg Arg Tyr Leu Glu Asn Gly Lys Glu Thr Leu Gln Arg 
305                 310                 315                 320 


Thr Asp Ala Pro Lys Thr His Met Thr His His Ala Val Ser Asp His 
                325                 330                 335     


Glu Ala Thr Leu Arg Cys Trp Ala Leu Ser Phe Tyr Pro Ala Glu Ile 
            340                 345                 350         


Thr Leu Thr Trp Gln Arg Asp Gly Glu Asp Gln Thr Gln Asp Thr Glu 
        355                 360                 365             


Leu Val Glu Thr Arg Pro Ala Gly Asp Gly Thr Phe Gln Lys Trp Val 
    370                 375                 380                 


Ala Val Val Val Pro Ser Gly Gln Glu Gln Arg Tyr Thr Cys His Val 
385                 390                 395                 400 


Gln His Glu Gly Leu Pro Lys Pro Leu Thr Leu Lys Trp Glu Pro Ser 
                405                 410                 415     


Ser Gln Ser Gly Gly Leu Asn Asp Ile Phe Glu Ala Gln Lys Ile Glu 
            420                 425                 430         


Trp His Glu Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Ser Gly 
        435                 440                 445             


Gly Gly Gly Ser Glu Val Asp Gly Gly Gly Gly Gly Leu Thr Asp Thr 
    450                 455                 460                 


Leu Gln Ala Glu Thr Asp Gln Leu Glu Asp Glu Lys Ser Ala Leu Gln 
465                 470                 475                 480 


Thr Glu Ile Ala Asn Leu Leu Lys Glu Lys Glu Lys Leu Glu Phe Ile 
                485                 490                 495     


Leu Ala Ala His 
            500 


<210>  38
<211>  387
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  38

Lys Pro His Pro Ala Glu Gly Gln Trp Arg Ala Val Asp Val Val Leu 
1               5                   10                  15      


Asp Cys Phe Leu Val Lys Asp Gly Ala His Arg Gly Ala Leu Ala Ser 
            20                  25                  30          


Ser Glu Asp Arg Ala Arg Ala Ser Leu Val Leu Lys Gln Val Pro Val 
        35                  40                  45              


Leu Asp Asp Gly Ser Leu Glu Asp Phe Thr Asp Phe Gln Gly Gly Thr 
    50                  55                  60                  


Leu Ala Gln Asp Asp Pro Pro Ile Ile Phe Glu Ala Ser Val Asp Leu 
65                  70                  75                  80  


Val Gln Ile Pro Gln Ala Glu Ala Leu Leu His Ala Asp Ala Ser Gly 
                85                  90                  95      


Lys Glu Val Thr Cys Glu Ile Ser Arg Tyr Phe Leu Gln Met Thr Glu 
            100                 105                 110         


Thr Thr Val Lys Thr Ala Ala Trp Phe Met Ala Asn Val Gln Val Ser 
        115                 120                 125             


Gly Gly Gly Pro Ser Ile Ser Leu Val Met Lys Thr Pro Arg Val Ala 
    130                 135                 140                 


Lys Asn Glu Val Leu Trp His Pro Thr Leu Asn Leu Pro Leu Ser Pro 
145                 150                 155                 160 


Gln Gly Thr Val Arg Thr Ala Val Glu Phe Gln Val Met Thr Gln Thr 
                165                 170                 175     


Gln Ser Leu Ser Phe Leu Leu Gly Ser Ser Ala Ser Leu Asp Cys Gly 
            180                 185                 190         


Phe Ser Met Ala Pro Gly Leu Asp Leu Ile Ser Val Glu Trp Arg Leu 
        195                 200                 205             


Gln His Lys Gly Arg Gly Gln Leu Val Tyr Ser Trp Thr Ala Gly Gln 
    210                 215                 220                 


Gly Gln Ala Val Arg Lys Gly Ala Thr Leu Glu Pro Ala Gln Leu Gly 
225                 230                 235                 240 


Met Ala Arg Asp Ala Ser Leu Thr Leu Pro Gly Leu Thr Ile Gln Asp 
                245                 250                 255     


Glu Gly Thr Tyr Ile Cys Gln Ile Thr Thr Ser Leu Tyr Arg Ala Gln 
            260                 265                 270         


Gln Ile Ile Gln Leu Asn Ile Gln Ala Ser Pro Lys Val Arg Leu Ser 
        275                 280                 285             


Leu Ala Asn Glu Ala Leu Leu Pro Thr Leu Ile Cys Asp Ile Ala Gly 
    290                 295                 300                 


Tyr Tyr Pro Leu Asp Val Val Val Thr Trp Thr Arg Glu Glu Leu Gly 
305                 310                 315                 320 


Gly Ser Pro Ala Gln Val Ser Gly Ala Ser Phe Ser Ser Leu Arg Gln 
                325                 330                 335     


Ser Val Ala Gly Thr Tyr Ser Ile Ser Ser Ser Leu Thr Ala Glu Gly 
            340                 345                 350         


Ser Ala Gly Ala Thr Tyr Thr Cys Gln Val Thr His Ile Ser Leu Glu 
        355                 360                 365             


Glu Pro Leu Gly Ala Ser Thr Gln Val Val Pro Pro Glu Arg Arg Leu 
    370                 375                 380                 


Glu Gly Ala 
385         


<210>  39
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  39

Lys Val Asp Gly Gly Gly Gly Gly Arg Ile Ala Arg Leu Glu Glu Lys 
1               5                   10                  15      


Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr Ala Asn 
            20                  25                  30          


Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Val Met Asn 
        35                  40                  45      


<210>  40
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  40

Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  41
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  41

Ser Gly Gly Gly Gly Ser 
1               5       


<210>  42
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  42

Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser 
1               5                   10      


<210>  43
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  43

Trp Ser His Pro Gln Phe Glu Lys 
1               5               


<210>  44
<211>  494
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  44

Lys Pro His Pro Ala Glu Gly Gln Trp Arg Ala Val Asp Val Val Leu 
1               5                   10                  15      


Asp Cys Phe Leu Val Lys Asp Gly Ala His Arg Gly Ala Leu Ala Ser 
            20                  25                  30          


Ser Glu Asp Arg Ala Arg Ala Ser Leu Val Leu Lys Gln Val Pro Val 
        35                  40                  45              


Leu Asp Asp Gly Ser Leu Glu Asp Phe Thr Asp Phe Gln Gly Gly Thr 
    50                  55                  60                  


Leu Ala Gln Asp Asp Pro Pro Ile Ile Phe Glu Ala Ser Val Asp Leu 
65                  70                  75                  80  


Val Gln Ile Pro Gln Ala Glu Ala Leu Leu His Ala Asp Ala Ser Gly 
                85                  90                  95      


Lys Glu Val Thr Cys Glu Ile Ser Arg Tyr Phe Leu Gln Met Thr Glu 
            100                 105                 110         


Thr Thr Val Lys Thr Ala Ala Trp Phe Met Ala Asn Val Gln Val Ser 
        115                 120                 125             


Gly Gly Gly Pro Ser Ile Ser Leu Val Met Lys Thr Pro Arg Val Ala 
    130                 135                 140                 


Lys Asn Glu Val Leu Trp His Pro Thr Leu Asn Leu Pro Leu Ser Pro 
145                 150                 155                 160 


Gln Gly Thr Val Arg Thr Ala Val Glu Phe Gln Val Met Thr Gln Thr 
                165                 170                 175     


Gln Ser Leu Ser Phe Leu Leu Gly Ser Ser Ala Ser Leu Asp Cys Gly 
            180                 185                 190         


Phe Ser Met Ala Pro Gly Leu Asp Leu Ile Ser Val Glu Trp Arg Leu 
        195                 200                 205             


Gln His Lys Gly Arg Gly Gln Leu Val Tyr Ser Trp Thr Ala Gly Gln 
    210                 215                 220                 


Gly Gln Ala Val Arg Lys Gly Ala Thr Leu Glu Pro Ala Gln Leu Gly 
225                 230                 235                 240 


Met Ala Arg Asp Ala Ser Leu Thr Leu Pro Gly Leu Thr Ile Gln Asp 
                245                 250                 255     


Glu Gly Thr Tyr Ile Cys Gln Ile Thr Thr Ser Leu Tyr Arg Ala Gln 
            260                 265                 270         


Gln Ile Ile Gln Leu Asn Ile Gln Ala Ser Pro Lys Val Arg Leu Ser 
        275                 280                 285             


Leu Ala Asn Glu Ala Leu Leu Pro Thr Leu Ile Cys Asp Ile Ala Gly 
    290                 295                 300                 


Tyr Tyr Pro Leu Asp Val Val Val Thr Trp Thr Arg Glu Glu Leu Gly 
305                 310                 315                 320 


Gly Ser Pro Ala Gln Val Ser Gly Ala Ser Phe Ser Ser Leu Arg Gln 
                325                 330                 335     


Ser Val Ala Gly Thr Tyr Ser Ile Ser Ser Ser Leu Thr Ala Glu Gly 
            340                 345                 350         


Ser Ala Gly Ala Thr Tyr Thr Cys Gln Val Thr His Ile Ser Leu Glu 
        355                 360                 365             


Glu Pro Leu Gly Ala Ser Thr Gln Val Val Pro Pro Glu Arg Arg Leu 
    370                 375                 380                 


Glu Gly Ala Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ala Ser 
385                 390                 395                 400 


Gly Gly Gly Gly Ser Glu Asn Leu Tyr Phe Gln Ser Ser Gly Gly Gly 
                405                 410                 415     


Gly Ser Lys Val Asp Gly Gly Gly Gly Gly Arg Ile Ala Arg Leu Glu 
            420                 425                 430         


Glu Lys Val Lys Thr Leu Lys Ala Gln Asn Ser Glu Leu Ala Ser Thr 
        435                 440                 445             


Ala Asn Met Leu Arg Glu Gln Val Ala Gln Leu Lys Gln Val Met Asn 
    450                 455                 460                 


Trp Ser His Pro Gln Phe Glu Lys Gly Gly Gly Ser Gly Gly Gly Ser 
465                 470                 475                 480 


Gly Gly Ser Ala Trp Ser His Pro Gln Phe Glu Lys Ala Ala 
                485                 490                 


